phenytoin has been researched along with valproate sodium in 37 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (5.41) | 18.7374 |
| 1990's | 1 (2.70) | 18.2507 |
| 2000's | 7 (18.92) | 29.6817 |
| 2010's | 26 (70.27) | 24.3611 |
| 2020's | 1 (2.70) | 2.80 |
| Authors | Studies |
|---|---|
| Biziere, K; Brochard, J; Brodin, R; Chambon, JP; Hallot, A; Merlier, J | 1 |
| Bartholini, G; Desarmenien, M; Feltz, P; Headley, PM; Kaplan, JP; Lloyd, KG; Raizon, BM; Worms, P | 1 |
| Bastide, P; Coudert, P; Couquelet, J; Gardette, D; Moreau, S; Rubat, C; Tronche, P; Vallee-Goyet, D | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Jatav, V; Kashaw, S; Mishra, P; Stables, JP | 2 |
| Antkiewicz-Michaluk, L; Marona, H; Pekala, E; Szneler, E; Walczak, M | 1 |
| Kohn, H; Morieux, P; Stables, JP | 1 |
| Jain, NK; Kashaw, SK; Kashaw, V; Mishra, P; Stables, JP | 1 |
| Cotten, SW; Eyers, C; Gaskell, SJ; Kohn, H; Liu, R; Morieux, P; Park, KD; Reamtong, O; Salomé, C; Stables, JP | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| DeMarco, E; Kohn, H; Morieux, P; Park, KD; Salomé, C; Salomé-Grosjean, E; Stables, JP; Swendiman, R | 1 |
| Ahsan, W; Siddiqui, N | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Kohn, H; Salomé, C; Salomé-Grosjean, E; Stables, JP | 1 |
| Deshmukh, R; Kharya, MD; Mishra, P; Rajak, H; Sharma, AK; Veerasamy, R | 1 |
| Chawla, G; Kaushik, D; Khan, SA; Kumar, S | 1 |
| Chawla, G; Kaushik, D; Khan, SA | 1 |
| He, X; Hu, X; Pan, Y; Qiu, G; Wu, W; Wu, Z; Xiao, Y; Yang, J; Zhang, T; Zhong, M | 1 |
| Singh, R; Stables, JP; Tripathi, L | 1 |
| Deng, XQ; Quan, LN; Quan, ZS; Song, MX; Wei, CX | 1 |
| De Ryck, M; Kaminski, R; King, AM; Kohn, H; Salomé, C; Salomé-Grosjean, E; Stables, JP; Valade, A | 1 |
| De Ryck, M; Kaminski, R; King, AM; Kohn, H; Stables, JP; Valade, A | 1 |
| Ghodke, M; Khan, FK; Nikalje, AP | 1 |
| Kumar, P; Singh, R; Stables, JP; Tripathi, L | 1 |
| Guo, H; He, X; Hu, X; Qiu, G; Wu, Z; Xiao, Y; Yang, J; Zhang, T; Zhong, M | 1 |
| Baruah, PK; De Ryck, M; Dinsmore, J; Kaminski, R; King, AM; Kohn, H; Provins, L; Salomé, C | 1 |
| Alagöz, MA; Calış, U; Dalkara, S; Karakurt, A; Sayoğlu, B | 1 |
| Amir, M; Hassan, MZ; Khan, SA | 1 |
| Kharya, MD; Raghuvanshi, K; Rajak, H; Sah, AK; Sharma, PC; Singh Pawar, R; Singh Thakur, B; Singh, A; Veerasamy, R | 1 |
| Kumar, P; Tripathi, L | 1 |
| Deng, XQ; Quan, ZS; Song, MX; Zheng, Y | 1 |
| Ahuja, P; Siddiqui, N | 1 |
| Chońska, J; Dawidowski, M; Mika, W; Turło, J | 1 |
| Kalam Khan, FA; Nikalje, APG; Sangshetti, JN; Shaikh, AN; Shaikh, SI; Shinde, DB | 1 |
| Ayati, A; Emami, S; Foroumadi, A | 1 |
| Akhtar, MJ; Bhatia, R; Grover, G; Nath, R | 1 |
2 review(s) available for phenytoin and valproate sodium
| Article | Year |
|---|---|
The importance of triazole scaffold in the development of anticonvulsant agents.
Topics: Animals; Anticonvulsants; Drug Discovery; Epilepsy; Humans; Triazoles | 2016 |
Synthetic and therapeutic perspectives of nitrogen containing heterocycles as anti-convulsants.
Topics: Animals; Anticonvulsants; Heterocyclic Compounds; Humans; Molecular Structure; Seizures; Structure-Activity Relationship | 2020 |
35 other study(ies) available for phenytoin and valproate sodium
| Article | Year |
|---|---|
Synthesis and activity of 6-aryl-3-(hydroxypolymethyleneamino)pyridazines in animal models of epilepsy.
Topics: Animals; Anticonvulsants; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Female; Hypnotics and Sedatives; Kindling, Neurologic; Male; Mice; Motor Skills; Papio; Pentylenetetrazole; Photic Stimulation; Pyridazines; Rats; Rats, Inbred Strains; Seizures; Structure-Activity Relationship | 1986 |
New anticonvulsants: Schiff bases of gamma-aminobutyric acid and gamma-aminobutyramide.
Topics: Animals; Anticonvulsants; Bicuculline; Brain; Cerebellum; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Ganglia, Spinal; Humans; In Vitro Techniques; Lethal Dose 50; Male; Mice; Rats; Schiff Bases | 1980 |
Synthesis and anticonvulsant properties of new benzylpyridazine derivatives.
Topics: Animals; Anticonvulsants; Lamotrigine; Male; Mice; Molecular Conformation; Pyridazines; Structure-Activity Relationship; Triazines | 1994 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Synthesis and CNS depressant activity of some novel 3-[5-substituted 1,3,4-thiadiazole-2-yl]-2-styryl quinazoline-4(3H)-ones.
Topics: Animals; Behavior, Animal; Central Nervous System Depressants; Drug Design; Electroshock; Mice; Pentylenetetrazole; Quinazolinones; Rats; Thiadiazoles | 2008 |
CNS depressant and anticonvulsant activities of some novel 3-[5-substituted 1,3,4-thiadiazole-2-yl]-2-styryl quinazoline-4(3H)-ones.
Topics: Animals; Anticonvulsants; Central Nervous System Depressants; Drug Design; Male; Mice; Motor Activity; Quinazolinones; Rats | 2008 |
Anticonvulsant activity of some xanthone derivatives.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Mice; Molecular Structure; Pentylenetetrazole; Rats; Seizures; Xanthones | 2008 |
Synthesis and anticonvulsant activities of N-benzyl (2R)-2-acetamido-3-oxysubstituted propionamide derivatives.
Topics: Acetamides; Animals; Anticonvulsants; Binding Sites; Lacosamide; Male; Mice; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship | 2008 |
Synthesis, anticonvulsant and CNS depressant activity of some new bioactive 1-(4-substituted-phenyl)-3-(4-oxo-2-phenyl/ethyl-4H-quinazolin-3-yl)-urea.
Topics: Animals; Anticonvulsants; Behavior, Animal; Central Nervous System Depressants; Male; Mice; Molecular Structure; Pentylenetetrazole; Quinazolinones; Rats; Rats, Sprague-Dawley; Rats, Wistar; Seizures; Structure-Activity Relationship; Urea | 2009 |
Lacosamide isothiocyanate-based agents: novel agents to target and identify lacosamide receptors.
Topics: Acetamides; Animals; Anticonvulsants; Brain; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Isothiocyanates; Lacosamide; Male; Mice; Mice, Inbred ICR; Nerve Tissue Proteins; Proteome; Seizures; Serine; Stereoisomerism; Structure-Activity Relationship | 2009 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Synthesis and anticonvulsant activities of (R)-N-(4'-substituted)benzyl 2-acetamido-3-methoxypropionamides.
Topics: Acetamides; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electroshock; Hippocampus; Kindling, Neurologic; Male; Mice; Molecular Structure; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Serine; Structure-Activity Relationship | 2010 |
Triazole incorporated thiazoles as a new class of anticonvulsants: design, synthesis and in vivo screening.
Topics: Animals; Anticonvulsants; Drug Design; Electroconvulsive Therapy; Lethal Dose 50; Mice; Triazoles | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Merging the structural motifs of functionalized amino acids and alpha-aminoamides: compounds with significant anticonvulsant activities.
Topics: Acetamides; Alanine; Amides; Amino Acids; Animals; Anticonvulsants; Benzylamines; Drug Evaluation, Preclinical; Lacosamide; Mice; Pain; Rats; Seizures; Structure-Activity Relationship; Treatment Outcome | 2010 |
Novel semicarbazones based 2,5-disubstituted-1,3,4-oxadiazoles: one more step towards establishing four binding site pharmacophoric model hypothesis for anticonvulsant activity.
Topics: Animals; Anticonvulsants; Binding Sites; Models, Molecular; Oxadiazoles; Rats; Semicarbazones | 2010 |
N'-[(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)methylene] 2/4-substituted hydrazides: synthesis and anticonvulsant activity.
Topics: Animals; Anticonvulsants; Behavior, Animal; Dose-Response Relationship, Drug; Electroshock; Hydrazines; Male; Mice; Nervous System; Pentylenetetrazole; Seizures; Time Factors | 2010 |
Design & synthesis of 2-(substituted aryloxy)-5-(substituted benzylidene)-3-phenyl-2,5-dihydro-1H-[1,2,4] triazin-6-one as potential anticonvulsant agents.
Topics: Animals; Anticonvulsants; Behavior, Animal; Drug Design; Electroshock; Male; Mice; Nervous System; Pentylenetetrazole; Seizures; Triazines | 2010 |
Synthesis and anticonvulsant activity of N-3-arylamide substituted 5,5-cyclopropanespirohydantoin derivatives.
Topics: Amides; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Hydantoins; Mice; Molecular Structure; Seizures; Spiro Compounds; Stereoisomerism; Structure-Activity Relationship | 2010 |
Design & synthesis of N'-[substituted] pyridine-4-carbohydrazides as potential anticonvulsant agents.
Topics: Algorithms; Animals; Anticonvulsants; Cell Death; Computer Simulation; Dose-Response Relationship, Drug; Drug Design; Electroshock; Hydrazines; Mice; Molecular Structure; Neurons; Pentylenetetrazole; Pyridines; Rats; Seizures; Stereoisomerism | 2011 |
Synthesis and anticonvulsant activity of 7-phenyl-6,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-ones and their derivatives.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bicuculline; Electroshock; Isoniazid; Mice; Pentylenetetrazole; Pyrimidinones; Seizures; Semicarbazides; Structure-Activity Relationship; Triazoles | 2011 |
Primary amino acid derivatives: substitution of the 4'-N'-benzylamide site in (R)-N'-benzyl 2-amino-3-methylbutanamide, (R)-N'-benzyl 2-amino-3,3-dimethylbutanamide, and (R)-N'-benzyl 2-amino-3-methoxypropionamide provides potent anticonvulsants with pain
Topics: Amino Acids; Analgesics; Animals; Anticonvulsants; Butyrates; Male; Mice; Neuralgia; Pain Measurement; Propionates; Rats; Rats, Sprague-Dawley; Seizures; Stereoisomerism; Structure-Activity Relationship | 2011 |
Defining the structural parameters that confer anticonvulsant activity by the site-by-site modification of (R)-N'-benzyl 2-amino-3-methylbutanamide.
Topics: Aminobutyrates; Animals; Anticonvulsants; Male; Mice; Rats; Rats, Sprague-Dawley; Seizures; Solubility; Stereoisomerism; Structure-Activity Relationship | 2011 |
Design and synthesis of 2-(1, 3-dioxoisoindolin-2-yl)-N-(4-oxo-2-substitutedthiazolidin-3-yl) acetamide derivatives as potential anticonvulsant agents.
Topics: Acetamides; Animals; Anticonvulsants; Behavior, Animal; Chemistry Techniques, Synthetic; Drug Design; Green Chemistry Technology; Male; Mice; Microwaves; Toxicity Tests, Acute | 2011 |
Design, synthesis and anticonvulsant evaluation of novel N-(4-substituted phenyl)-2-[4-(substituted) benzylidene]-hydrazinecarbothio amides.
Topics: Animals; Anticonvulsants; Drug Design; Epilepsy; Hydrogen Bonding; Male; Mice; Models, Molecular; Protein Conformation; Rats; Receptors, GABA-A; Thioamides | 2012 |
Synthesis and anticonvulsant activity of 1-(8-(benzyloxy)quinolin-2-yl)-6-substituted-4,6-diazaspiro[2,4]heptane-5,7-diones.
Topics: Animals; Anticonvulsants; Biological Assay; Electroshock; Heptanes; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mice; Molecular Structure; Quinolines; Seizures; Spiro Compounds; Structure-Activity Relationship; Toxicity Tests | 2012 |
Synthesis, anticonvulsant activity, and neuropathic pain-attenuating activity of N-benzyl 2-amino-2-(hetero)aromatic acetamides.
Topics: Acetamides; Amino Acids; Animals; Anticonvulsants; Disease Models, Animal; Drug Evaluation, Preclinical; Male; Mice; Mice, Inbred Strains; Molecular Structure; Neuralgia; Seizures; Structure-Activity Relationship | 2012 |
Synthesis of some novel 1-(2-naphthyl)-2-(imidazol-1-yl)ethanone oxime ester derivatives and evaluation of their anticonvulsant activity.
Topics: Animals; Anticonvulsants; Electroshock; Esters; Imidazoles; Isomerism; Mice; Motor Activity; Naphazoline; Neuropsychological Tests; Oximes; Seizures; Structure-Activity Relationship | 2012 |
Design, synthesis and evaluation of N-(substituted benzothiazol-2-yl)amides as anticonvulsant and neuroprotective.
Topics: Acrylamide; Amides; Animals; Anticonvulsants; Benzothiazoles; Brain; Dose-Response Relationship, Drug; Drug Design; Female; Male; Mice; Models, Molecular; Molecular Structure; Neuroprotective Agents; Pentylenetetrazole; Seizures; Structure-Activity Relationship; Swimming | 2012 |
Novel limonene and citral based 2,5-disubstituted-1,3,4-oxadiazoles: a natural product coupled approach to semicarbazones for antiepileptic activity.
Topics: Acyclic Monoterpenes; Animals; Anticonvulsants; Binding Sites; Cyclohexenes; Disease Models, Animal; gamma-Aminobutyric Acid; Limonene; Monoterpenes; Oxadiazoles; Protein Binding; Rats; Seizures; Semicarbazones; Structure-Activity Relationship; Terpenes | 2013 |
Augmentation of GABAergic neurotransmission by novel N-(substituted)-2-[4-(substituted)benzylidene]hydrazinecarbothioamides-a potential anticonvulsant approach.
Topics: Animals; Anticonvulsants; Electroshock; GABAergic Neurons; Hydrazines; Male; Mice; Mice, Inbred Strains; Models, Molecular; Molecular Structure; Rats; Rats, Sprague-Dawley; Seizures; Thioamides | 2013 |
Design, synthesis and evaluation of the antidepressant and anticonvulsant activities of triazole-containing quinolinones.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Electroshock; Exploratory Behavior; Male; Mice; Mice, Inbred Strains; Molecular Structure; Quinolones; Rotarod Performance Test; Seizures; Swimming; Triazoles | 2014 |
Anticonvulsant evaluation of clubbed indole-1,2,4-triazine derivatives: a synthetic approach.
Topics: Animals; Anticonvulsants; Brain; Chemistry Techniques, Synthetic; gamma-Aminobutyric Acid; Male; Mice; Motor Activity; Sodium Channels; Triazines | 2014 |
Novel fluorinated pyrrolo[1,2-a]pyrazine-2,6-dione derivatives: synthesis and anticonvulsant evaluation in animal models of epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Epilepsy; Halogenation; Hydrocarbons, Fluorinated; Male; Mice; Molecular Structure; Pentylenetetrazole; Pilocarpine; Pyrazines; Pyrroles; Rats; Rats, Sprague-Dawley; Seizures; Structure-Activity Relationship | 2014 |
Microwave assisted synthesis and docking study of N-(2-oxo-2-(4-oxo-2-substituted thiazolidin-3ylamino)ethyl)benzamide derivatives as anticonvulsant agents.
Topics: Animals; Anticonvulsants; Benzamides; Binding Sites; Disease Models, Animal; Half-Life; Liver; Mice; Microwaves; Molecular Docking Simulation; Motor Activity; Protein Structure, Tertiary; Seizures; Sodium Channels; Thiazolidines | 2014 |