phenytoin and trimethadione

phenytoin has been researched along with trimethadione in 137 studies

Research

Studies (137)

Timeframe	Studies, this research(%)	All Research%
pre-1990	119 (86.86)	18.7374
1990's	5 (3.65)	18.2507
2000's	6 (4.38)	29.6817
2010's	7 (5.11)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Brouillette, WJ; Brown, GB; DeLorey, TM; Grunewald, GL; Shirali, SS	1
Akhtar, MS; Brouillette, WJ; Brown, GB; Brown, ML; DeLorey, TM; Jestkov, VP	1
Bruno-Blanch, L; Gálvez, J; García-Domenech, R	1
Jolivette, LJ; Ward, KW	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Park, JY; Park, MS; Sharma, G	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Bruno-Blanch, LE; Enrique, A; Marder, M; Pastore, V; Sabatier, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Bohlen, N; Hertl, M	1
Gandhi, IC; Jindal, MN; Patel, VK	1
Araki, Y; Ueki, S; Watanabe, S	1
Majewski, F	1
Hori, M; Ito, T; Shimizu, M; Yoshida, K	3
Göbel, W; Löscher, W	1
Shepard, TH	1
Boisse, NR; Okamoto, M; Rosenberg, HC	1
Faugier-Grimaud, S	1
Goodman, RM; Hertz, M; Katznelson, D; Katznelson, MB; Rotem, Y	1
Knotts, GR; Thomas, JA	1
Bigler, ED; Fleming, DE; Shearer, DE	1
Gardner, CR; Webster, RA	2
Anderson, RC	1
Chiu, P; Colasanti, BK; Craig, CR	1
Cook, WL; Gerald, MC; Gupta, TK; Witiak, DT	1
Fishman, L; Hanson, V; Singsen, BH	1
Danielson, MG; Fowler, GW; Julien, RM	1
Banna, NR; Kurkjian, R	1
Aderet, NB; Biale, Y; Lewenthal, H	1
Dam, M; Kiørboe, E	1
Andrews, JS; Bortolotto, ZA; Bressler, K; Calderazzo-Filho, LS; Cavalheiro, EA; Löschmann, PA; Turski, L	1
Cennamo, M; Piccione, E; Ticconi, C	1
Greco, GS; Nagai, MK; Wells, PG	1
Lee, EK; Walters, JR; Waszczak, BL	1
Vorhees, CV	2
Dalessio, DJ	1
Depaulis, A; Marescaux, C; Micheletti, G; Reis, J; Rumbach, L; Vergnes, M; Warter, JM	1
Frey, HH; Löscher, W	1
Stumpf, DA	1
Khera, KS	1
Krip, G; Vazquez, AJ	1
Ansorge, R; Thoenes, G; Thoenes, W	1
Eadie, MJ; Tyrer, JH	1
Deitrich, RA; Erwin, VG	1
Gogerty, JH; Iorio, LC; Ryan, EA	1
Crandall, BF; Lippe, BM	1
Lossing, JH; Saper, JR	1
Eldredge, NT; Jiller, JJ; van Robertson, WB	1
Glaser, GE; Grove, I; Marino, BB; Pincus, JH	1
Millichap, JG	2
Fromm, GH; Kohli, CM	1
Hooshmand, H; Suter, CG	1
Hooshmand, H	1
Sayers, A; Stille, G	1
Banziger, R; Hane, D	1
Olesen, OV	1
Laycock, GM; Shulman, A	1
Rümke, CL	1
Friedlander, WJ	1
Downes, H; Williams, JK	1
Buchanan, AS; Laycock, GM; Shulman, A	1
Wolf, HH; Yeoh, PN	1
Mandel, HG; Riis, M	1
Kutt, H; Louis, S	1
Izquierdo, I	2
Crawford, RD; Crichlow, EC; Johnson, DD	1
Beam, RE	1
Halpern, LM; Julien, RM	2
Kirsten, EB; Schoener, EP	1
Zellweger, H	1
Kutt, H	1
Nolte, H; von Schnakenburg, K	1
Cremers, HM; Verheesen, PE	1
Berry, CA; Faingold, CL	1
Dondov, P; Rachkov, BM; Zhavzma, D	1
Perchalski, RJ; Wilder, BJ	1
Izquierdo, I; Tannhauser, M	1
Swinyard, EA	1
Ando, J; Kiehi, Y	1
Fukuta, T; Shimazono, Y	1
Halpern, LM; Ward, AA	1
Borgstedt, AD; Bryson, MF; Forbes, GB; Young, LW	1
Andermann, F	1
Koe, BK; Weissman, A	1
Ahmad, A; Dhawan, BN	1
Dua, PR; Kohli, RP; Rastogi, SK; Singh, N; Sinha, JN	1
Blackburn, WH; Napoli, MD; Wallin, RF	1
Copsey, K; Deichmann, WB; Hamill, T; MacDonald, WE; MacQueen, J	1
Downes, H; Karler, R; Ostlund, RE; Perry, RS	1
Southgate, PJ	1
Endröczi, E; Fekete, T	1
Caldeira, JA; Ramos, AO; Ramos, L	1
Ferngren, H; Paalzow, L	1
Burba, JV	1
Carl, J; King, LJ	1
Spilker, B; Yeager, CL	1
Krupp, P	1
Dang, HC; Visek, WJ	1
Bartels, E; Rosenberg, P	1
Bender, AD; Greene, L; Macko, E; Tedeschi, RE; Wilfon, G	1
Bruni, J; Wilder, BJ	1
Ito, K; Murata, T; Nioka, M; Owada, E; Sato, J	1
Chernoff, GF; Jones, KL	1
Friis, ML	1
Albright, PS; Bruni, J	1
Harned, HS	1
Kayama, Y	1
Goldner, JC	1
Freeman, JJ; Kosh, JW; Powers, DL; Sowell, JW	1
Arai, M; Miura, S; Oana, Y	1
Burnham, WM; King, GA; Livingston, KE	1
Callaghan, DA; Schwark, WS	1
Amano, T; Fujita, Y; Hanaya, R; Matsubayashi, H; Sasa, M; Serikawa, T; Ujihara, H; Uozumi, T	1
Kelly, KM; Macdonald, RL	1
Azarbayjani, F; Danielsson, BR	2
KUEHN, A; SCHALLEK, W	1
HANSEN, HA; NORDQVIST, P; SOURANDER, P	1
HOLLEY, HL	1
HUSTON, MJ; RIEDEL, BE	1
DUBOIS, EL	1
LOEWE, S	1
BELNAP, WD; GOODMAN, LS; TOMAN, JE	1
DRIVER, RL; ORDWAY, GL	1
Bruno-Blanch, LE; Higgs, J; Mangialavori, IC; Marder, M; Pastore, V; Wasowski, C	1

Reviews

17 review(s) available for phenytoin and trimethadione

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
[On certain embryopathies induced by teratogenic agents (author's transl]. Monatsschrift fur Kinderheilkunde, 1977, Volume: 125, Issue:6 Topics: Abnormalities, Drug-Induced; Aminopterin; Busulfan; Chlorambucil; Cyclophosphamide; Ethanol; Germany, West; Heroin Dependence; Humans; Infant Mortality; Infant, Newborn; Lysergic Acid Diethylamide; Mercaptopurine; Nicotine; Phenytoin; Radiation Injuries; Teratogens; Thalidomide; Trimethadione; Warfarin	1977
[Problems of neurological drug therapy in pregnancy]. La Clinica terapeutica, 1989, Apr-30, Volume: 129, Issue:2 Topics: Abnormalities, Drug-Induced; Anticonvulsants; Antiparkinson Agents; Carbamazepine; Chelating Agents; Female; Fetus; Haloperidol; Humans; Nervous System Diseases; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications; Trimethadione; Valproic Acid	1989
Current concepts. Seizure disorders and pregnancy. The New England journal of medicine, 1985, Feb-28, Volume: 312, Issue:9 Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Drug Administration Schedule; Epilepsy; Female; Fetal Blood; Hemorrhage; Humans; Infant, Newborn; Monitoring, Physiologic; Phenytoin; Pregnancy; Pregnancy Complications; Trimethadione	1985
Pharmacokinetics of anti-epileptic drugs in the dog: a review. Journal of veterinary pharmacology and therapeutics, 1985, Volume: 8, Issue:3 Topics: Animals; Anticonvulsants; Blood Proteins; Carbamazepine; Clonazepam; Diazepam; Dog Diseases; Dogs; Epilepsy; Ethosuximide; Kinetics; Phenobarbital; Phenytoin; Primidone; Species Specificity; Trimethadione; Valproic Acid	1985
Plasma levels of anticonvulsants. Australian and New Zealand journal of medicine, 1973, Volume: 3, Issue:3 Topics: Administration, Oral; Adult; Animals; Anticonvulsants; Barbiturates; Blood Proteins; Carbamazepine; Child; Chromatography, Gas; Chromatography, Thin Layer; Diazepam; Epilepsy; Ethosuximide; Humans; Infant; Liver; Phenytoin; Protein Binding; Spectrophotometry; Thiazines; Trimethadione	1973
Relation of laboratory evaluation to clinical effectiveness of antiepileptic drugs. Epilepsia, 1969, Volume: 10, Issue:2 Topics: Acetazolamide; Adrenocorticotropic Hormone; Animals; Anticonvulsants; Benzazepines; Clinical Trials as Topic; Drug Tolerance; Electroencephalography; Electroshock; Epilepsy; Ethosuximide; Humans; Pentylenetetrazole; Phenobarbital; Phenytoin; Primidone; Seizures; Trimethadione; Urea	1969
Toxic effects of anticonvulsants: general principles. Pediatrics, 1974, Volume: 53, Issue:4 Topics: Adrenocorticotropic Hormone; Adult; Anticonvulsants; Benzodiazepinones; Body Surface Area; Body Weight; Carbamazepine; Child; Chlorobenzenes; Diagnosis, Differential; Diazepam; Drug Interactions; Drug Therapy, Combination; Epilepsy; Half-Life; Humans; Nitro Compounds; Phenobarbital; Phenytoin; Primidone; Succinimides; Tranquilizing Agents; Trimethadione	1974
Epilepsy. Progress in neurology and psychiatry, 1967, Volume: 22 Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Amphetamine; Anesthetics, Local; Anticonvulsants; Barbiturates; Birth Injuries; Brain Injuries; Brain Neoplasms; Carbonic Anhydrase Inhibitors; Central Nervous System Stimulants; Child; Child, Preschool; Conditioning, Psychological; Cortisone; Diet Therapy; Electroencephalography; Epilepsy; Ethanol; Female; Hormones; Humans; Immunization; Infections; Male; Meprobamate; Metabolic Diseases; Middle Aged; Oxygen; Phenytoin; Pyrrolidinones; Reflex, Abnormal; Toxins, Biological; Trimethadione	1967
Anticonvulsants during pregnancy: a danger to the developing fetus? Clinical pediatrics, 1974, Volume: 13, Issue:4 Topics: Abnormalities, Drug-Induced; Anticonvulsants; Barbiturates; Blood Coagulation Disorders; Chromosome Aberrations; Chromosome Disorders; Female; Fetus; Folic Acid; Humans; Infant, Newborn; Phenytoin; Pregnancy; Pregnancy Complications; Primidone; Succinimides; Trimethadione; Vitamin K; Vitamin K Deficiency Bleeding	1974
Pharmacodynamic and pharmacokinetic measurements of antiepileptic drugs. Clinical pharmacology and therapeutics, 1974, Volume: 16, Issue:1 Topics: Anticonvulsants; Chromatography, Gas; Dose-Response Relationship, Drug; Ethosuximide; Humans; Phenobarbital; Phenytoin; Primidone; Trimethadione	1974
Laboratory evaluation of antiepileptic drugs. Review of laboratory methods. Epilepsia, 1969, Volume: 10, Issue:2 Topics: Animals; Anticonvulsants; Biological Assay; Brain Injuries; Diagnosis; Electroconvulsive Therapy; Electroshock; Humans; Methionine Sulfoximine; Methods; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Seizures; Strychnine; Thiosemicarbazones; Trimethadione; Urea	1969
[Drug therapy of epilepsy]. Naika. Internal medicine, 1967, Volume: 19, Issue:6 Topics: Epilepsy; Epilepsy, Tonic-Clonic; Humans; Phenobarbital; Phenytoin; Trimethadione; Urea	1967
Fetal preventive medicine: teratogens and the unborn baby. Pediatric annals, 1981, Volume: 10, Issue:6 Topics: Abnormalities, Drug-Induced; Dronabinol; Drug Evaluation; Ethanol; Female; Heroin; Hormones; Hot Temperature; Humans; Lysergic Acid Diethylamide; Phenytoin; Pregnancy; Registries; Teratogens; Trimethadione; Warfarin; X-Rays	1981
The clinical pharmacology of antiepileptic drugs. Clinical neuropharmacology, 1984, Volume: 7, Issue:1 Topics: Adult; Anticonvulsants; Benzodiazepines; Carbamazepine; Drug Interactions; Ethosuximide; Female; Half-Life; Humans; Intestinal Absorption; Kidney; Kidney Diseases; Kinetics; Liver Diseases; Phenobarbital; Phenytoin; Pregnancy; Primidone; Protein Binding; Tissue Distribution; Trimethadione; Valproic Acid	1984
Cardiovascular problems of the newborn and their etiologies. Progress in clinical and biological research, 1983, Volume: 140 Topics: Amphetamines; Animals; Cardiovascular Diseases; Estrogens; Ethanol; Female; Fetal Hypoxia; Heart Defects, Congenital; Heart Function Tests; Heart Septal Defects; Humans; Infant, Newborn; Lithium; Lithium Carbonate; Persistent Fetal Circulation Syndrome; Phenytoin; Pregnancy; Pregnancy in Diabetics; Progesterone; Salicylates; Tricuspid Valve; Trimethadione	1983
Antiepileptic drug mechanisms of action. Epilepsia, 1995, Volume: 36 Suppl 2 Topics: Acetates; Action Potentials; Amines; Animals; Anticonvulsants; Barbiturates; Benzodiazepines; Calcium Channels; Carbamazepine; Central Nervous System; Cyclohexanecarboxylic Acids; Epilepsy; Gabapentin; gamma-Aminobutyric Acid; Humans; Ion Channels; Lamotrigine; Phenytoin; Rats; Receptors, GABA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sodium Channels; Triazines; Trimethadione; Valproic Acid; Vigabatrin	1995

Trials

1 trial(s) available for phenytoin and trimethadione

Article	Year
Relation of laboratory evaluation to clinical effectiveness of antiepileptic drugs. Epilepsia, 1969, Volume: 10, Issue:2 Topics: Acetazolamide; Adrenocorticotropic Hormone; Animals; Anticonvulsants; Benzazepines; Clinical Trials as Topic; Drug Tolerance; Electroencephalography; Electroshock; Epilepsy; Ethosuximide; Humans; Pentylenetetrazole; Phenobarbital; Phenytoin; Primidone; Seizures; Trimethadione; Urea	1969

Article

Year

Relation of laboratory evaluation to clinical effectiveness of antiepileptic drugs.

Epilepsia, 1969, Volume: 10, Issue:2

Topics: Acetazolamide; Adrenocorticotropic Hormone; Animals; Anticonvulsants; Benzazepines; Clinical Trials as Topic; Drug Tolerance; Electroencephalography; Electroshock; Epilepsy; Ethosuximide; Humans; Pentylenetetrazole; Phenobarbital; Phenytoin; Primidone; Seizures; Trimethadione; Urea

1969

Other Studies

120 other study(ies) available for phenytoin and trimethadione

Article	Year
Anticonvulsant activities of phenyl-substituted bicyclic 2,4-oxazolidinediones and monocyclic models. Comparison with binding to the neuronal voltage-dependent sodium channel. Journal of medicinal chemistry, 1988, Volume: 31, Issue:11 Topics: Animals; Anticonvulsants; Binding Sites; Bridged Bicyclo Compounds; Bridged-Ring Compounds; Cerebral Cortex; Drug Evaluation, Preclinical; Mice; Neurons; Oxazoles; Sodium Channels; Structure-Activity Relationship; Synaptosomes	1988
Bicyclic hydantoins with a bridgehead nitrogen. Comparison of anticonvulsant activities with binding to the neuronal voltage-dependent sodium channel. Journal of medicinal chemistry, 1994, Sep-30, Volume: 37, Issue:20 Topics: Alkylation; Animals; Anticonvulsants; Cyclization; Hydantoins; Mice; Molecular Structure; Neurons; Nitrogen; Sodium Channels; Structure-Activity Relationship	1994
Topological virtual screening: a way to find new anticonvulsant drugs from chemical diversity. Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16 Topics: Anticonvulsants; Computer Simulation; Databases, Factual; Discriminant Analysis; Drug Design; Molecular Structure; Quantitative Structure-Activity Relationship	2003
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. Journal of pharmaceutical sciences, 2005, Volume: 94, Issue:7 Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution	2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Design and synthesis of 6-amino-1,4-oxazepane-3,5-dione derivatives as novel broad spectrum anticonvulsants. Bioorganic & medicinal chemistry letters, 2008, Jun-01, Volume: 18, Issue:11 Topics: Animals; Anticonvulsants; Combinatorial Chemistry Techniques; Drug Design; Electroshock; Male; Mice; Molecular Structure; Oxazepines; Pentylenetetrazole; Seizures	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Synthesis and anticonvulsant activity of bioisosteres of trimethadione, N-derivative-1,2,3-oxathiazolidine-4-one-2,2-dioxides from α-hydroxyamides. Bioorganic & medicinal chemistry, 2013, Feb-15, Volume: 21, Issue:4 Topics: Amides; Animals; Anticonvulsants; Behavior, Animal; Male; Mice; Microwaves; Phenytoin; Seizures; Structure-Activity Relationship; Thiazolidines; Trimethadione	2013
[Adverse effects of anti-epileptic drugs]. Deutsche medizinische Wochenschrift (1946), 1975, Sep-19, Volume: 100, Issue:38 Topics: Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Carbamazepine; Diazepam; Epilepsy; Ethosuximide; Humans; Mephenytoin; Nitrazepam; Phenytoin; Primidone; Succinimides; Thiazines; Trimethadione; Valproic Acid	1975
Mechaism of neuromuscular blockade with some antiepileptic drugs. Arzneimittel-Forschung, 1976, Volume: 26, Issue:2 Topics: Abdominal Muscles; Anesthetics, Local; Animals; Anticonvulsants; Cats; Diaphragm; Ethosuximide; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscles; Neuromuscular Blocking Agents; Neuromuscular Junction; Neuromuscular Nondepolarizing Agents; Phenobarbital; Phenytoin; Rabbits; Rats; Trimethadione	1976
Changes in sensitivity of mice to anticonvulsant drugs following bilateral olfactory bulb ablations. Japanese journal of pharmacology, 1977, Volume: 27, Issue:2 Topics: Acetazolamide; Animals; Anticonvulsants; Chlordiazepoxide; Diazepam; Dose-Response Relationship, Drug; Electroshock; Male; Mice; Nitrazepam; Olfactory Bulb; Phenobarbital; Phenylacetates; Phenytoin; Trimethadione; Urea; Valproic Acid	1977
Effect of anticonvulsants on thalamic afterdischarge in rats and cats. Japanese journal of pharmacology, 1977, Volume: 27, Issue:6 Topics: Acetazolamide; Animals; Anticonvulsants; Carbamazepine; Cats; Diazepam; Electrocardiography; Electroencephalography; Female; Male; Phenobarbital; Phenytoin; Rats; Thalamus; Trimethadione; Valproic Acid	1977
Consecutive gas chromatographic determination of phenytoin, phenobarbital, primidone, phenylethylmalondiamide, carbamazepine, trimethadione, dimethadione, ethosuximide, and valproate from the same serum specimen. Epilepsia, 1978, Volume: 19, Issue:5 Topics: Anticonvulsants; Carbamazepine; Chromatography, Gas; Dimethadione; Ethosuximide; Phenobarbital; Phenylethylmalonamide; Phenytoin; Primidone; Trimethadione; Valproic Acid	1978
Effect of anticonvulsants on spiking activity induced by cortical freezing in cats. Epilepsia, 1979, Volume: 20, Issue:1 Topics: Acetazolamide; Animals; Anticonvulsants; Arousal; Carbamazepine; Cats; Diazepam; Electrocardiography; Electroencephalography; Female; Freezing; Gallamine Triethiodide; Immobilization; Male; Phenobarbital; Phenytoin; Taurine; Trimethadione; Valproic Acid; Visual Cortex	1979
Effect of anticonvulsants on cortical focal seizure in cats. Epilepsia, 1977, Volume: 18, Issue:1 Topics: Acetazolamide; Animals; Anticonvulsants; Carbamazepine; Cats; Diazepam; Electrocardiography; Epilepsies, Partial; Female; Heart; Male; Phenobarbital; Phenytoin; Seizures; Trimethadione; Valproic Acid	1977
Teratogenicity of therapeutic agents. Current problems in pediatrics, 1979, Volume: 10, Issue:2 Topics: Abnormalities, Drug-Induced; Abnormalities, Radiation-Induced; Abortion, Induced; Anesthetics; Animals; Anticoagulants; Antineoplastic Agents; Aspirin; Congenital Abnormalities; Drug Evaluation; Drug Evaluation, Preclinical; Female; Hormones; Humans; Male; Methylmercury Compounds; Phenytoin; Pregnancy; Teratogens; Tetracycline; Thalidomide; Tranquilizing Agents; Trimethadione	1979
Evaluation of anticonvulsants in barbiturate withdrawal. The Journal of pharmacology and experimental therapeutics, 1977, Volume: 202, Issue:2 Topics: Animals; Anticonvulsants; Behavior, Animal; Cats; Dimethadione; Female; Humans; Male; Pentobarbital; Phenobarbital; Phenytoin; Seizures; Substance Withdrawal Syndrome; Time Factors; Trimethadione	1977
Action of anticonvulsants on pentylenetetrazol-induced epileptiform activity on invertebrate neurones (Helix aspersa). Neuropharmacology, 1978, Volume: 17, Issue:11 Topics: Action Potentials; Amobarbital; Animals; Anticonvulsants; Diazepam; Epilepsy; Helix, Snails; In Vitro Techniques; Neurons; Pentylenetetrazole; Phenytoin; Trimethadione	1978
Congenital malformations in four siblings of a mother taking anticonvulsant drugs. American journal of diseases of children (1960), 1976, Volume: 130, Issue:8 Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Child; Child, Preschool; Epilepsy, Tonic-Clonic; Female; Humans; Infant; Male; Phenobarbital; Phenytoin; Pregnancy; Primidone; Trimethadione	1976
Epilepsy and other seizure disorders in children: drug management. The Journal of school health, 1976, Volume: 46, Issue:8 Topics: Acetazolamide; Anticonvulsants; Child; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Clonic; Humans; Phenobarbital; Phenytoin; Primidone; Succinimides; Trimethadione	1976
The photically evoked afterdischarge: a model for the study of drugs useful in the treatment of petit mal epilepsy. Epilepsia, 1976, Volume: 17, Issue:4 Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Absence; Evoked Potentials; Female; Pentylenetetrazole; Phenytoin; Rats; Sodium Chloride; Trimethadione; Valproic Acid	1976
Convulsant-anticonvulsant interactions on seizure activity and cortical acetylcholine release. European journal of pharmacology, 1977, Apr-07, Volume: 42, Issue:3 Topics: Acetylcholine; Animals; Anticonvulsants; Bicuculline; Blood Pressure; Cerebral Cortex; Convulsants; Drug Interactions; Electroencephalography; Male; Pentylenetetrazole; Phenobarbital; Phenytoin; Rats; Seizures; Time Factors; Trimethadione	1977
Cardiac defects in children of mothers receiving anticonvulsant therapy during pregnancy. The Journal of pediatrics, 1976, Volume: 89, Issue:2 Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Cleft Lip; Cleft Palate; Dimethadione; Drug Therapy, Combination; Epilepsy; Ethosuximide; Female; Heart Defects, Congenital; Humans; Infant, Newborn; Male; Mephobarbital; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications; Trimethadione	1976
Effects of diphenylhydantoin and trimethadione on seizure activity during cobalt experimental epilepsy in the rat. Neuropharmacology, 1976, Volume: 15, Issue:8 Topics: Animals; Cobalt; Female; Oxazoles; Phenytoin; Rats; Seizures; Time Factors; Trimethadione	1976
Para-substituted N-acetyl-L(S)- and -D(R)-alpha-amino-N-phenylglutarimides. A structure-activity study of substituent effects on steroselective anticonvulsant activity. Journal of medicinal chemistry, 1976, Volume: 19, Issue:12 Topics: Animals; Anticonvulsants; Ethosuximide; Male; Mice; Phenytoin; Piperidines; Piperidones; Seizures; Stereoisomerism; Structure-Activity Relationship; Trimethadione	1976
Antinuclear antibodies and lupus-like syndromes in children receiving anticonvulsants. Pediatrics, 1976, Volume: 57, Issue:4 Topics: Adolescent; Adult; Antibodies, Antinuclear; Anticonvulsants; Child; Child, Preschool; Ethosuximide; Female; Humans; Infant; Lupus Erythematosus, Systemic; Male; Mephenytoin; Phenobarbital; Phenytoin; Seizures; Succinimides; Trimethadione	1976
The effects of antiepileptic drugs on estrogen-induced electrographic spike-wave discharge. The Journal of pharmacology and experimental therapeutics, 1975, Volume: 193, Issue:2 Topics: Acetazolamide; Animals; Anticonvulsants; Carbamazepine; Cats; Clonazepam; Clorazepate Dipotassium; Diazepam; Electroencephalography; Estrogens; Ethosuximide; Female; Imipramine; Lidocaine; Male; Motor Cortex; Phenytoin; Stereotaxic Techniques; Trimethadione	1975
A novel tremorigen antagonized by D-amphetamine. Brain research, 1975, Apr-04, Volume: 87, Issue:1 Topics: Acetates; Aldehydes; Amines; Animals; Atropine; Calcium; Chlorpromazine; Dextroamphetamine; Diazepam; Diphenhydramine; Ganglionic Stimulants; Histidine; Male; Mice; Oximes; Phenoxybenzamine; Phenytoin; Propranolol; Scopolamine; Thiophenes; Tremor; Trimethadione	1975
Congenital malformations due to anticonvulsive drugs. Obstetrics and gynecology, 1975, Volume: 45, Issue:4 Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anencephaly; Anticonvulsants; Birth Order; Cleft Lip; Cleft Palate; Epilepsy; Female; Fetal Death; Folic Acid; Folic Acid Antagonists; Hemorrhage; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications; Primidone; Trimethadione	1975
[Current viewpoints in drug treatment of epilepsy, with reference to the most common drugs in current use]. Ugeskrift for laeger, 1975, Oct-06, Volume: 137, Issue:41 Topics: Anticonvulsants; Carbamazepine; Clonazepam; Epilepsy; Ethosuximide; Humans; Phenobarbital; Phenytoin; Trimethadione	1975
Drugs for epilepsy. The Medical letter on drugs and therapeutics, 1976, Mar-12, Volume: 18, Issue:6 Topics: Anticonvulsants; Carbamazepine; Clonazepam; Diazepam; Epilepsy; Ethosuximide; Humans; Phenobarbital; Phenytoin; Primidone; Trimethadione	1976
Substantia nigra regulates action of antiepileptic drugs. Brain research, 1990, Jun-18, Volume: 520, Issue:1-2 Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroencephalography; Ethosuximide; Male; Microinjections; Midazolam; Phenobarbital; Phenytoin; Pilocarpine; Rats; Rats, Inbred Strains; Seizures; Substantia Nigra; Trimethadione	1990
Inhibition of trimethadione and dimethadione teratogenicity by the cyclooxygenase inhibitor acetylsalicylic acid: a unifying hypothesis for the teratologic effects of hydantoin anticonvulsants and structurally related compounds. Toxicology and applied pharmacology, 1989, Mar-01, Volume: 97, Issue:3 Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Cleft Palate; Dealkylation; Dimethadione; Dose-Response Relationship, Drug; Female; Mice; Oxazoles; Phenytoin; Pregnancy; Trimethadione	1989
Effects of anticonvulsant drugs on substantia nigra pars reticulata neurons. The Journal of pharmacology and experimental therapeutics, 1986, Volume: 239, Issue:2 Topics: Animals; Anticonvulsants; Carbamazepine; Clonazepam; Dose-Response Relationship, Drug; Ethosuximide; Male; Neurons; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Substantia Nigra; Trimethadione; Valproic Acid	1986
Fetal anticonvulsant exposure: effects on behavioral and physical development. Annals of the New York Academy of Sciences, 1986, Volume: 477 Topics: Animals; Anticonvulsants; Female; Humans; Learning; Memory; Motor Activity; Oxazoles; Phenobarbital; Phenytoin; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Reflex, Startle; Trimethadione	1986
Antiepileptic drug evaluation in a new animal model: spontaneous petit mal epilepsy in the rat. Arzneimittel-Forschung, 1985, Volume: 35, Issue:2 Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Drug Evaluation, Preclinical; Electroencephalography; Epilepsy, Absence; Ethosuximide; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Trimethadione; Valproic Acid	1985
Anticonvulsant use during pregnancy. Clinical therapeutics, 1985, Volume: 7, Issue:2 Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Fetal Death; Humans; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications; Risk; Trimethadione	1985
Phenytoin and trimethadione: pharmacokinetics, embryotoxicity, and maternal toxicity. Progress in clinical and biological research, 1985, Volume: 163C Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Half-Life; Humans; Infant, Newborn; Kinetics; Oxazoles; Phenytoin; Pregnancy; Pregnancy, Animal; Risk; Trimethadione	1985
Effects of diphenylhydantoin and cholinergic agents on the neuronally isolated cerebral cortex. Electroencephalography and clinical neurophysiology, 1971, Volume: 30, Issue:5 Topics: Animals; Atropine; Cats; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Ethosuximide; Parasympathomimetics; Phenytoin; Physostigmine; Pilocarpine; Scopolamine; Seizures; Synaptic Transmission; Trimethadione	1971
[Drug-induced lupus-nephritis light-, electron- and immunfluorescence-microscopic investigations on kidney biopsies (author's transl)]. Verhandlungen der Deutschen Gesellschaft fur Pathologie, 1972, Volume: 56 Topics: Adolescent; Anticonvulsants; Biopsy; Child; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Kidney; Lupus Erythematosus, Systemic; Male; Microscopy, Electron; Microscopy, Fluorescence; Nephritis; Phenytoin; Trimethadione	1972
Inhibition of bovine brain aldehyde reductase by anticonvulsant compounds in vitro. Biochemical pharmacology, 1973, Oct-15, Volume: 22, Issue:20 Topics: Aldehyde Oxidoreductases; Amobarbital; Animals; Anticonvulsants; Barbiturates; Brain; Cattle; Ethosuximide; Hydantoins; Hydrogen-Ion Concentration; In Vitro Techniques; Isomerism; Kinetics; Mephobarbital; NADP; Pentobarbital; Phenobarbital; Phenytoin; Spectrometry, Fluorescence; Spectrophotometry; Succinimides; Trimethadione	1973
Anticonvulsant testing with a new analeptic convulsant: N-sulfamoyl-hexahydro-azepine (Sah 41-178). Archives internationales de pharmacodynamie et de therapie, 1973, Volume: 206, Issue:2 Topics: Acetamides; Animals; Anticonvulsants; Azepines; Central Nervous System Stimulants; Chlordiazepoxide; Chlorpromazine; Diazepam; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electroshock; Glutethimide; Haloperidol; Male; Mice; Pentylenetetrazole; Phenobarbital; Phenytoin; Strychnine; Sulfonamides; Trimethadione	1973
Turner syndrome with partial deletion of the X chromosome long arm. American journal of diseases of children (1960), 1973, Volume: 126, Issue:2 Topics: Adolescent; Amenorrhea; Dermatoglyphics; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Female; Follicle Stimulating Hormone; Growth Disorders; Humans; Intelligence Tests; Karyotyping; Luteinizing Hormone; Nephrotic Syndrome; Nevus, Pigmented; Phenotype; Phenytoin; Sex Chromatin; Thymidine; Thyroxine; Trimethadione; Tritium; Turner Syndrome	1973
Prolonged trance-like stupor in epilepsy. Petit mal status-wave stupor, spaced-out status. Archives of internal medicine, 1974, Volume: 134, Issue:6 Topics: Adult; Behavior; Diagnosis, Differential; Diazepam; Electroencephalography; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Female; Humans; Intelligence; Male; Middle Aged; Phenytoin; Primidone; Trimethadione; Unconsciousness	1974
The interaction of lupus-inducing drugs with deoxyribonucleic acid. Clinical immunology and immunopathology, 1974, Volume: 3, Issue:2 Topics: Adult; Animals; Cattle; Child; DNA; DNA, Single-Stranded; Hot Temperature; Humans; Hydralazine; Immunodiffusion; Isoniazid; Lupus Erythematosus, Systemic; Methyldopa; Nucleic Acid Conformation; Nucleic Acid Denaturation; Optical Rotation; Oxazoles; Phenytoin; Procainamide; Propylthiouracil; Thymus Gland; Trimethadione; Viscosity	1974
Studies on the mechanism of action of diphenylhydantoin. Archives of neurology, 1970, Volume: 22, Issue:6 Topics: Adenosine Triphosphatases; Animals; Biological Transport; Crustacea; Cyanides; Hypoxia; Neurons; Ouabain; Peripheral Nerves; Phenobarbital; Phenytoin; Potassium; Schwann Cells; Sodium; Tetrodotoxin; Trimethadione	1970
Drug treatment of convulsive disorders. The New England journal of medicine, 1972, Mar-02, Volume: 286, Issue:9 Topics: Acetazolamide; Adrenocorticotropic Hormone; Adult; Anticonvulsants; Barbiturates; Child; Diazepam; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Ethosuximide; Humans; Infant; Myoclonus; Oxazoles; Phenobarbital; Phenytoin; Primidone; Pyrrolidinones; Seizures; Trimethadione	1972
The role of inhibitory pathways in petit mal epilepsy. Neurology, 1972, Volume: 22, Issue:10 Topics: Action Potentials; Animals; Anticonvulsants; Carbamazepine; Cats; Cerebral Cortex; Electric Stimulation; Epilepsy, Absence; Ethosuximide; Maxillary Nerve; Neural Inhibition; Phenytoin; Synaptic Transmission; Trigeminal Nerve; Trimethadione	1972
Classification and treatment of seizure disorders in children. Virginia medical monthly, 1970, Volume: 97, Issue:2 Topics: Acetazolamide; Adolescent; Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Clonic; Ethosuximide; Humans; Infant; Infant, Newborn; Male; Nitrazepam; Oxazoles; Phenytoin; Seizures; Succinimides; Trimethadione	1970
Motor convulsions and EEG during maximal electroshock in the rat. International journal of neuropharmacology, 1967, Volume: 6, Issue:3 Topics: Animals; Anticonvulsants; Cerebral Cortex; Cornea; Electric Stimulation; Electroencephalography; Electroshock; Muscles; Phenobarbital; Phenytoin; Primidone; Rats; Seizures; Stress, Physiological; Succinimides; Thiazines; Trimethadione	1967
Evaluation of a new convulsant for anticonvulsant screening. Archives internationales de pharmacodynamie et de therapie, 1967, Volume: 167, Issue:2 Topics: Acetazolamide; Animals; Anticonvulsants; Cats; Central Nervous System Stimulants; Chlordiazepoxide; Diazepam; Ethosuximide; Female; Male; Mice; Phenobarbital; Phenytoin; Pyrimidines; Thiazines; Trimethadione	1967
Determination of phenobarbital and phenytoin in serum by ultraviolet spectrophotometry. Scandinavian journal of clinical and laboratory investigation, 1967, Volume: 20, Issue:1 Topics: Barbiturates; Chromatography, Thin Layer; Humans; Phenobarbital; Phenytoin; Salicylamides; Spectrophotometry; Sulfadimethoxine; Sulfamethoxypyridazine; Thiazines; Trimethadione; Ultraviolet Rays	1967
Action of central nervous system stimulant and depressant drugs in the intact animal. 3. Dual action of 5-ethyl-5-(1,3-dimethylbutyl)barbiturate, dilantin and beta-methyl-beta-eta-propylglutarimide. European journal of pharmacology, 1967, Volume: 2, Issue:1 Topics: Animals; Anticonvulsants; Barbiturates; Bemegride; Central Nervous System; Central Nervous System Stimulants; Depression, Chemical; Drug Antagonism; Hypnotics and Sedatives; Mice; Pentobarbital; Pentylenetetrazole; Phenytoin; Piperidines; Sensory Receptor Cells; Stimulation, Chemical; Trimethadione	1967
Increased susceptibility of mice to seizures after some anticonvulsant drugs. European journal of pharmacology, 1967, Volume: 1, Issue:5 Topics: Animals; Anticonvulsants; Bemegride; Central Nervous System Stimulants; Drug Synergism; Electroshock; Ethionine; Female; Hydantoins; Male; Methods; Mice; Oxazines; Pentylenetetrazole; Phenobarbital; Phenytoin; Primidone; Rats; Seizures; Trimethadione	1967
Effects of a convulsant barbiturate on the spinal monosynaptic pathway. The Journal of pharmacology and experimental therapeutics, 1969, Volume: 168, Issue:2 Topics: Animals; Barbiturates; Blood Pressure; Cats; Central Nervous System Stimulants; Lumbosacral Region; Pentobarbital; Phenytoin; Reflex; Reflex, Monosynaptic; Spinal Cord; Synapses; Trimethadione	1969
Action of central nervous system stimulant and depressant drugs in the intact animal. 4. Surface activity of drugs with central stimulant depressant, or dual stimulant-depressant action. European journal of pharmacology, 1969, Volume: 7, Issue:1 Topics: Air; Amobarbital; Barbiturates; Central Nervous System Stimulants; Chemical Phenomena; Chemistry; Depression, Chemical; Glutarates; Hypnotics and Sedatives; Oxazines; Pentobarbital; Pentylenetetrazole; Phenytoin; Picrotoxin; Pregnanediones; Solutions; Stimulation, Chemical; Surface Properties; Surface Tension; Trimethadione	1969
Pharmacological evaluation of seizures induced by electrical stimulation of the hippocampus. Journal of pharmaceutical sciences, 1970, Volume: 59, Issue:7 Topics: Amino Alcohols; Anilides; Animals; Electric Stimulation; Ethanolamines; Hippocampus; Male; Methods; Phenethylamines; Phenytoin; Propranolol; Rats; Seizures; Sulfonic Acids; Trimethadione	1970
Interference of barbiturates with pyrimidine incorporation. II. Structural specificity of the inhibition of orotate uptake in Bacillus cereus. Biochemical pharmacology, 1970, Volume: 19, Issue:6 Topics: Amobarbital; Bacillus cereus; Barbiturates; Bemegride; Biological Transport; Carbon Isotopes; Carboxylic Acids; Central Nervous System Stimulants; Chemical Phenomena; Chemistry; Chemistry, Physical; Chlorine; Chlorpromazine; Glutethimide; Hexobarbital; Hydantoins; Hydrocarbons, Halogenated; Hydrogen-Ion Concentration; Orotic Acid; Pentobarbital; Phenobarbital; Phenytoin; Primidone; Solubility; Succinimides; Thiopental; Thymine; Trimethadione; Tromethamine; Uracil; Urea	1970
Anticonvulsant drugs. I. Patho-physiological and pharmacological aspects. Drugs, 1972, Volume: 4, Issue:3 Topics: Acetates; Acetazolamide; Anticonvulsants; Carbamazepine; Diazepam; Dibenzazepines; Electroencephalography; Epilepsies, Partial; Epilepsy; Ethosuximide; Humans; Phenobarbital; Phenytoin; Primidone; Seizures; Succinimides; Thiazines; Trimethadione	1972
Effect on pseudoconditioning of drugs with known central nervous activity. Psychopharmacologia, 1974, Volume: 38, Issue:3 Topics: Amobarbital; Animals; Avoidance Learning; Behavior, Animal; Caffeine; Cannabis; Chlorpromazine; Conditioning, Psychological; Depression, Chemical; Diazepam; Dibenzylchlorethamine; Female; Meprobamate; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Rats; Stimulation, Chemical; Strychnine; Trimethadione	1974
Epileptiform seizures in domestic fowl. IV. The effects of anticonvulsant drugs. Canadian journal of physiology and pharmacology, 1974, Volume: 52, Issue:5 Topics: Animals; Anticonvulsants; Chickens; Diazepam; Electroencephalography; Phenobarbital; Phenytoin; Photic Stimulation; Seizures; Trimethadione	1974
Broad-spectrum simultaneous GLC assay of nonderivatized antiepileptic drugs. The American journal of medical technology, 1974, Volume: 40, Issue:5 Topics: Anticonvulsants; Barbiturates; Carbamazepine; Chromatography, Gas; Ethosuximide; Humans; Phenobarbital; Phenytoin; Primidone; Quality Control; Trimethadione	1974
Augmentation of cerebellar Purkinje cell discharge rate after diphenylhydantoin. Epilepsia, 1972, Volume: 13, Issue:3 Topics: Acetazolamide; Action Potentials; Cerebellum; Electroencephalography; Epilepsy; Phenobarbital; Phenytoin; Purkinje Cells; Trimethadione	1972
Effects of diphenylhydantoin and other antiepileptic drugs on epileptiform activity and Purkinje cell discharge rates. Epilepsia, 1972, Volume: 13, Issue:3 Topics: Acetazolamide; Action Potentials; Animals; Anticonvulsants; Blood Pressure; Cats; Cerebellum; Electroencephalography; Epilepsy; Penicillins; Phenobarbital; Phenytoin; Purkinje Cells; Trimethadione	1972
Antagonism of pentylenetetrazol excitation by anticonvulsants on single brain stem neurons. Neuropharmacology, 1972, Volume: 11, Issue:4 Topics: Animals; Anticonvulsants; Brain Stem; Cats; Decerebrate State; Diazepam; Drug Antagonism; In Vitro Techniques; Microelectrodes; Neurons; Pentobarbital; Pentylenetetrazole; Phenytoin; Stereotaxic Techniques; Time Factors; Trimethadione	1972
[Morphological and pharmacological-toxicological aspects of hyperoxia]. International journal of clinical pharmacology, therapy and toxicology, 1973, Volume: 7, Issue:4 Topics: Aminobutyrates; Animals; Atmospheric Pressure; Brain Diseases; Diazepam; Ganglia; Humans; Lung; Lung Diseases; Muscle Cramp; Oxygen; Partial Pressure; Phenobarbital; Phentolamine; Phenytoin; Pulmonary Edema; Rats; Time Factors; Trimethadione; Tromethamine	1973
The effect of some anticonvulsant drugs on leptazol and bicuculline induced acetylcholine efflux from rat cerebral cortex. British journal of pharmacology, 1973, Volume: 47, Issue:3 Topics: Acetylcholine; Alkaloids; Animals; Anticonvulsants; Cerebral Cortex; Dioxoles; Dose-Response Relationship, Drug; Electroencephalography; Isoquinolines; Pentylenetetrazole; Phenobarbital; Phenytoin; Rats; Seizures; Trimethadione	1973
A rapid method for the estimation of anti-epileptic drugs in blood serum by gas-liquid chromatography. Clinica chimica acta; international journal of clinical chemistry, 1973, Nov-15, Volume: 48, Issue:4 Topics: Anticonvulsants; Carbamazepine; Chromatography, Gas; Epilepsy; Ethosuximide; Evaluation Studies as Topic; Humans; Mephobarbital; Methods; Methylation; Microchemistry; Phenobarbital; Phenytoin; Primidone; Succinimides; Temperature; Time Factors; Trimethadione	1973
Quantitative evaluation of the pentylenetetrazol-anticonvulsant interaction on the EEG of the cat. European journal of pharmacology, 1973, Volume: 24, Issue:3 Topics: Animals; Anticonvulsants; Cats; Cerebral Cortex; Computers; Drug Interactions; Electroencephalography; Hippocampus; Pentylenetetrazole; Phenobarbital; Phenytoin; Reticular Formation; Thalamus; Time Factors; Trimethadione	1973
[Evaluation of the anticonvulsive effect of benzonal, trimetin and diphenin in the treatment of temporal lobe epilepsy]. Klinicheskaia meditsina, 1973, Volume: 51, Issue:9 Topics: Adolescent; Adult; Aged; Anticonvulsants; Barbiturates; Benzoates; Electroencephalography; Epilepsy, Temporal Lobe; Female; Humans; Male; Middle Aged; Phenytoin; Trimethadione	1973
Letter: GLC microdetermination of plasma anticonvulsant levels. Journal of pharmaceutical sciences, 1974, Volume: 63, Issue:5 Topics: Anticonvulsants; Chromatography, Gas; Ethosuximide; Humans; Methods; Phenobarbital; Phenytoin; Primidone; Trimethadione	1974
Effect of seizures and anticonvulsant agents on hippocampal RNA concentration. Pharmacology, 1974, Volume: 11, Issue:3 Topics: Anesthesia, General; Animals; Anticonvulsants; Cannabis; Cerebral Cortex; Depression, Chemical; Electric Stimulation; Electroshock; Glucose; Hippocampus; Hyponatremia; Male; Pentylenetetrazole; Phenobarbital; Phenytoin; Rats; RNA; Seizures; Time Factors; Trimethadione; Urethane	1974
Effect of anticonvulsant drugs on the number of afferent stimuli needed to cause a hippocampal seizure discharge. Pharmacology, 1974, Volume: 11, Issue:3 Topics: Animals; Anticonvulsants; Cannabis; Dose-Response Relationship, Drug; Electric Stimulation; Electroshock; Evoked Potentials; Hippocampus; Injections, Intraperitoneal; Neurons, Afferent; Phenobarbital; Phenytoin; Rats; Seizures; Time Factors; Trimethadione	1974
[Ethosuximide in treatment of petit mal epilepsy]. No to shinkei = Brain and nerve, 1965, Volume: 17, Issue:8 Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Electroencephalography; Epilepsy, Absence; Ethosuximide; Female; Humans; Male; Phenobarbital; Phenytoin; Trimethadione	1965
The hyperexcitable neuron as a model for the laboratory analysis of anticonvulsant drugs. Epilepsia, 1969, Volume: 10, Issue:2 Topics: Acetazolamide; Action Potentials; Aluminum; Animals; Behavior, Animal; Cats; Cerebral Cortex; Electroencephalography; Haplorhini; Hydroxides; Models, Biological; Neurons; Pentylenetetrazole; Phenobarbital; Phenytoin; Seizures; Time Factors; Trimethadione	1969
Long-term administration of antiepileptic drugs and the development of rickets. The Journal of pediatrics, 1972, Volume: 81, Issue:1 Topics: Alkaline Phosphatase; Anticonvulsants; Calcium; Diazepam; Ethosuximide; Female; Gluconates; Humans; Infant; Mephobarbital; Osteomalacia; Phenobarbital; Phenytoin; Phosphorus; Primidone; Radiography; Rickets; Seizures; Time Factors; Trimethadione; Vitamin D	1972
Self-induced television epilepsy. Epilepsia, 1971, Volume: 12, Issue:3 Topics: Adolescent; Electroencephalography; Epilepsy; Ethosuximide; Female; Humans; Myoclonus; Phenytoin; Television; Trimethadione	1971
m-Fluorotyrosine convulsions and mortality: relationship to catecholamine and citrate metabolism. The Journal of pharmacology and experimental therapeutics, 1967, Volume: 155, Issue:1 Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Anticonvulsants; Atropine; Azoles; Brain; Chlordiazepoxide; Chlorpromazine; Citrates; Dihydroxyphenylalanine; Disulfiram; Drug Antagonism; Drug Synergism; Kidney; Lysergic Acid Diethylamide; Male; Methyldopa; Mice; Morphine; Nialamide; Norepinephrine; Pargyline; Phenobarbital; Phenytoin; Reserpine; Seizures; Serotonin; Strychnine; Tetrabenazine; Trimethadione; Tyrosine; Urea	1967
Metrazol test for rapid screening of anticonvulsants. Japanese journal of pharmacology, 1969, Volume: 19, Issue:3 Topics: Animals; Anticonvulsants; Electroshock; Injections, Subcutaneous; Mice; Pentylenetetrazole; Phenytoin; Seizures; Trimethadione	1969
An experimental investigation on the antiarrhythmic activity of antiepileptic agents. Japanese journal of pharmacology, 1971, Volume: 21, Issue:6 Topics: Alkaloids; Animals; Anti-Arrhythmia Agents; Anticonvulsants; Arrhythmias, Cardiac; Coronary Vessels; Dogs; Electrocardiography; Epinephrine; Female; Ligation; Male; Oxazoles; Phenytoin; Quinidine; Trimethadione	1971
Pharmacologic interactions of albutoin with other anticonvulsant drugs. The Journal of pharmacology and experimental therapeutics, 1970, Volume: 174, Issue:2 Topics: Animals; Anticonvulsants; Drug Synergism; Electroshock; Hydantoins; Male; Mice; Pentylenetetrazole; Phenobarbital; Phenytoin; Seizures; Trimethadione	1970
Effect of parathion on liver microsomal enzyme activites induced by organochlorine pesticides and drugs in female rats. Internationales Archiv fur Arbeitsmedizin, 1970, Volume: 26, Issue:1 Topics: Animals; Azo Compounds; Chlordan; DDT; Dimenhydrinate; Female; Hydrocarbons, Halogenated; Microsomes, Liver; Naphthalenes; Oxidoreductases; Paraldehyde; Parathion; Phenobarbital; Phenytoin; Rats; Trimethadione	1970
A study of the excitatory effects of barbiturates. The Journal of pharmacology and experimental therapeutics, 1970, Volume: 175, Issue:3 Topics: Animals; Anticonvulsants; Barbiturates; Chemical Phenomena; Chemistry; Injections, Intravenous; Male; Mice; Pentobarbital; Phenobarbital; Phenytoin; Seizures; Stereoisomerism; Trimethadione	1970
A comparison of the anticonvulsant properties of 2-diethylaminopento-4-ynoyl-2',6'-xylidide (WY 21745) with lignocaine, phenytoin, phenobarbitone and trimethadione. Archives internationales de pharmacodynamie et de therapie, 1971, Volume: 191, Issue:2 Topics: Anesthetics, Local; Animals; Anticonvulsants; Drug Antagonism; Electroshock; Lethal Dose 50; Lidocaine; Mice; Oxazoles; Pentylenetetrazole; Phenobarbital; Phenytoin; Seizures; Trimethadione	1971
Amino acid composition of the Ammon's horn and the effect of anticonvulsant drugs. Acta physiologica Academiae Scientiarum Hungaricae, 1967, Volume: 32, Issue:4 Topics: Amino Acids; Animals; Anticonvulsants; Body Weight; Brain Chemistry; Chromatography, Paper; DNA; Hippocampus; Injections, Intraperitoneal; Male; Phenytoin; Primidone; Rats; Trimethadione	1967
[Eye hypotension due to anticonvulsants in rabbits]. Arquivos brasileiros de oftalmologia, 1967, Volume: 30, Issue:5 Topics: Animals; Anticonvulsants; Female; Intraocular Pressure; Male; Oxazoles; Phenobarbital; Phenytoin; Rabbits; Trimethadione	1967
Studies on electrically induced-seizures and their antagonism by anticonvulsants during neonatal development in the mouse. Acta pharmacologica et toxicologica, 1967, Volume: 25 Topics: Acetazolamide; Animals; Animals, Newborn; Anticonvulsants; Electric Stimulation; Ethosuximide; Mice; Phenobarbital; Phenytoin; Seizures; Trimethadione	1967
Influence of several drugs on the in vivo and in vitro activity of mammalian hepatic azo-reductase. Canadian journal of biochemistry, 1968, Volume: 46, Issue:4 Topics: Animals; Caffeine; Guanethidine; Guinea Pigs; In Vitro Techniques; Iproniazid; Isoniazid; Liver; Nitrofurantoin; Oxidoreductases; Pentylenetetrazole; Phenobarbital; Phenylbutazone; Phenytoin; Rabbits; Rats; Sulfinpyrazone; Sulfonic Acids; Trimethadione	1968
Effects of antiepileptic drugs on brain energy reserves during convulsions. Journal of neurochemistry, 1969, Volume: 16, Issue:4 Topics: Adenosine Triphosphate; Animals; Anticonvulsants; Brain Chemistry; Cerebral Cortex; Electroshock; Glucose; Lactates; Mice; Phenobarbital; Phenytoin; Phosphocreatine; Seizures; Trimethadione	1969
Ten years EEG studies in epileptic children (two cases). Diseases of the nervous system, 1969, Volume: 30, Issue:3 Topics: Adolescent; Child; Child, Preschool; Electroencephalography; Emotions; Epilepsy; Humans; Mephobarbital; Phenytoin; Primidone; Trimethadione	1969
[Electrophysiological studies on the mechanism of action of antiepileptics in animal experiments]. Helvetica paediatrica acta, 1969, Volume: 24, Issue:3 Topics: Animals; Anticonvulsants; Axons; Cats; Cerebral Cortex; Electric Stimulation; Hippocampus; Neural Conduction; Phenobarbital; Phenytoin; Rabbits; Spinal Cord; Synapses; Thalamus; Trimethadione	1969
Antagonism of urease toxicity by chemical agents and antisera. Toxicology and applied pharmacology, 1966, Volume: 8, Issue:2 Topics: Alloxan; Animals; Anticonvulsants; Arginine; Barbiturates; Glutamates; Immune Sera; Injections, Intraperitoneal; Male; Mice; Pentobarbital; Phenobarbital; Phenytoin; Rats; Trimethadione; Urease	1966
Drug effects on the spontaneous electrical activity of the squid giant axon. The Journal of pharmacology and experimental therapeutics, 1967, Volume: 155, Issue:3 Topics: Acetylcholine; Action Potentials; Animals; Anticonvulsants; Atropine; Axons; Barbiturates; Bromides; Chloroform; Chlorpheniramine; Chlorpromazine; Curare; Dopamine; Electrophysiology; Ethanol; Ethers; Evoked Potentials; Hydantoins; Mollusca; Muscles; Nortropanes; Parasympatholytics; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Procaine; Serotonin; Strychnine; Tetracaine; Tremorine; Trihexyphenidyl; Trimethadione	1967
Pharmacological properties of the isopropyl ester of o-sulfamoyl-benzoic acid. Archives internationales de pharmacodynamie et de therapie, 1967, Volume: 168, Issue:1 Topics: Animals; Behavior, Animal; Benzoates; Carbamates; Carisoprodol; Chlordiazepoxide; Chlormezanone; Chlorzoxazone; Dogs; Drug Antagonism; Electroshock; Male; Mephenesin; Meprobamate; Methocarbamol; Mice; Muscles; Pentobarbital; Phenethylamines; Phenobarbital; Phenytoin; Rats; Reflex; Seizures; Sleep; Strychnine; Trimethadione; Zoxazolamine	1967
Mechanisms of action of antiepileptic drugs. Clinical neuropharmacology, 1982, Volume: 5, Issue:1 Topics: Acetazolamide; Animals; Anti-Anxiety Agents; Anticonvulsants; Barbiturates; Benzodiazepines; Carbamazepine; Chemical Phenomena; Chemistry; Humans; Paraldehyde; Phenytoin; Primidone; Seizures; Succinimides; Trimethadione; Valproic Acid	1982
Effect of acetazolamide on the anticonvulsant potency of several antiepileptic drugs in mice. Journal of pharmacobio-dynamics, 1983, Volume: 6, Issue:5 Topics: Acetazolamide; Animals; Anticonvulsants; Barbital; Barbiturates; Brain; Drug Interactions; Male; Mephobarbital; Mice; Phenytoin; Time Factors; Trimethadione; Valproic Acid	1983
Fetal anticonvulsant syndrome in rats: dose- and period-response relationships of prenatal diphenylhydantoin, trimethadione and phenobarbital exposure on the structural and functional development of the offspring. The Journal of pharmacology and experimental therapeutics, 1983, Volume: 227, Issue:2 Topics: Abnormalities, Drug-Induced; Animals; Behavior, Animal; Developmental Disabilities; Dose-Response Relationship, Drug; Female; Fetus; Gestational Age; Humans; Locomotion; Oxazoles; Phenobarbital; Phenytoin; Pregnancy; Rats; Rats, Inbred Strains; Reflex, Startle; Swimming; Syndrome; Time Factors; Trimethadione	1983
Antiepileptic drugs and teratogenesis. How should patients, doctors and health authorities be counselled? Acta neurologica Scandinavica. Supplementum, 1983, Volume: 94 Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Infant, Newborn; Oxazoles; Phenytoin; Pregnancy; Pregnancy Complications; Primidone; Risk; Trimethadione; Valproic Acid	1983
Ketamine and e.e.g. seizure waves: interaction with anti-epileptic drugs. British journal of anaesthesia, 1982, Volume: 54, Issue:8 Topics: Anesthesia, Intravenous; Animals; Cats; Drug Interactions; Electroencephalography; Evoked Potentials, Visual; Ketamine; Phenytoin; Time Factors; Trimethadione; Visual Cortex	1982
Anticonvulsants and pregnancy. The Nebraska medical journal, 1981, Volume: 66, Issue:10 Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Phenytoin; Pregnancy; Pregnancy Complications; Trimethadione	1981
Anticonvulsant properties of selected pyrrolo[2,3-d]pyrimidine-2,4-diones and intermediates. Journal of pharmaceutical sciences, 1980, Volume: 69, Issue:4 Topics: Animals; Anticonvulsants; Electroshock; Male; Mice; Pentylenetetrazole; Phenytoin; Pyrimidinones; Pyrroles; Seizures; Solubility; Structure-Activity Relationship; Trimethadione	1980
[A study of effects on antiepileptic drugs upon the hippocampal afterdischarge (author's transl)]. Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 1980, Volume: 82, Issue:1 Topics: Animals; Anticonvulsants; Carbamazepine; Cats; Electric Stimulation; Female; Hippocampus; Male; Phenobarbital; Phenytoin; Seizures; Trimethadione	1980
Flash-evoked afterdischarge in rat as a model of the absence seizure: dose-response studies with therapeutic drugs. Epilepsia, 1980, Volume: 21, Issue:5 Topics: Acetazolamide; Animals; Dose-Response Relationship, Drug; Ethosuximide; Evoked Potentials; Male; Mephenytoin; Phenobarbital; Phenytoin; Photic Stimulation; Rats; Seizures; Trimethadione	1980
Pharmacological modification of amygdaloid-kindled seizures. Neuropharmacology, 1980, Volume: 19, Issue:11 Topics: Amygdala; Animals; Diazepam; Electric Stimulation; Electrodes, Implanted; Ketamine; Male; Phenobarbital; Phenytoin; Rats; Seizures; Trimethadione	1980
Effect of antiepileptic drugs on absence-like seizures in the tremor rat. Epilepsia, 1995, Volume: 36, Issue:9 Topics: Animals; Anticonvulsants; Data Interpretation, Statistical; Drug Therapy, Combination; Electroencephalography; Epilepsy, Absence; Ethosuximide; Female; Injections, Intraperitoneal; Male; Phenobarbital; Phenytoin; Rats; Rats, Inbred WKY; Rats, Mutant Strains; Seizures; Time Factors; Trimethadione; Valproic Acid	1995
Pharmacologically induced embryonic dysrhythmia and episodes of hypoxia followed by reoxygenation: a common teratogenic mechanism for antiepileptic drugs? Teratology, 1998, Volume: 57, Issue:3 Topics: Abnormalities, Drug-Induced; Animals; Anti-Arrhythmia Agents; Anticonvulsants; Arrhythmias, Cardiac; Carbamazepine; Female; Fetus; Heart; Humans; Hypoxia; Mice; Mice, Inbred C57BL; Phenobarbital; Phenytoin; Pregnancy; Rats; Trimethadione	1998
Embryonic arrhythmia by inhibition of HERG channels: a common hypoxia-related teratogenic mechanism for antiepileptic drugs? Epilepsia, 2002, Volume: 43, Issue:5 Topics: Abnormalities, Drug-Induced; Age Factors; Animals; Anticonvulsants; Arrhythmias, Cardiac; Cation Transport Proteins; Dimethadione; DNA-Binding Proteins; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Fetal Diseases; Fetal Heart; Fetal Hypoxia; Gestational Age; Heart Rate, Fetal; Maternal-Fetal Exchange; Mice; Myocardial Ischemia; Myocardial Reperfusion Injury; Patch-Clamp Techniques; Phenytoin; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pregnancy; Reactive Oxygen Species; Trans-Activators; Trimethadione	2002
Effects of trimethadione, diphenylhydantoin and chlordiazepoxide on after-discharges in brain of cat. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1963, Volume: 112 Topics: Animals; Anticonvulsants; Cats; Cerebral Cortex; Chlordiazepoxide; Felis; Hippocampus; Phenytoin; Thalamus; Trimethadione	1963
MEGALOBLASTIC ANEMIA AND NEUROLOGIC DISTURBANCES COMBINED WITH FOLIC ACID DEFICIENCY. OBSERVATIONS ON AN EPILEPTIC PATIENT TREATED WITH ANTICONVULSANTS. Acta medica Scandinavica, 1964, Volume: 176 Topics: Anemia; Anemia, Macrocytic; Anemia, Megaloblastic; Anticonvulsants; Avitaminosis; Barbiturates; Brain Diseases; Central Nervous System Diseases; Cerebellar Diseases; Drug Therapy; Epilepsy; Folic Acid; Folic Acid Deficiency; Humans; Neurologic Manifestations; Pathology; Phenobarbital; Phenytoin; Spinal Cord; Spinal Nerves; Toxicology; Trimethadione	1964
EVIDENCE FOR A PREDISPOSITION TO RHEUMATIC DISEASES IN FAMILIES OF PATIENTS DEVELOPING DRUG-INDUCED SYSTEMIC LUPUS ERYTHEMATOSUS. Arthritis and rheumatism, 1964, Volume: 7 Topics: Adolescent; Anticonvulsants; Child; Disease Susceptibility; Drug Therapy; Genetics, Medical; Humans; Lupus Erythematosus, Systemic; Phenytoin; Rheumatic Diseases; Toxicology; Trimethadione	1964
Effect of sodium kemithal, trimethadione, and sodium diphenylhydantoinate on skeletal muscle. Canadian journal of medical sciences, 1951, Volume: 29, Issue:4 Topics: Barbital; Hydantoins; Ions; Muscle, Skeletal; Muscles; Phenytoin; Sodium; Sodium, Dietary; Trimethadione	1951
Toxic hepatic necrosis associated with taking dilantin, tridione and phenobarbital; report of a case. American journal of clinical pathology, 1950, Volume: 20, Issue:2 Topics: Aged; Barbital; Hepatitis; Humans; Hydantoins; Liver; Liver Diseases; Phenobarbital; Phenytoin; Trimethadione	1950
Anticonvulsant actions of trimethadione-phenobarbital and trimethadione-diphenylhydantoin combinations. Federation proceedings, 1948, Volume: 7, Issue:1 Pt 1 Topics: Anticonvulsants; Humans; Phenobarbital; Phenytoin; Seizures; Trimethadione	1948
Tridione-diphenylhydantoin combination therapy in grand mal with slow-wave EEG dysrhythmia. Federation proceedings, 1947, Volume: 6, Issue:1 Topics: Combined Modality Therapy; Electroencephalography; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Phenytoin; Seizures; Trimethadione	1947
Comparative anticonvulsant actions of isopropyl alcohol, diphenylhydantoin, phenobarbital and tridione. Federation proceedings, 1947, Volume: 6, Issue:1 Topics: 1-Propanol; 2-Propanol; Anticonvulsants; Humans; Phenobarbital; Phenytoin; Propanols; Seizures; Trimethadione	1947
A synthetic bioisoster of trimethadione and phenytoin elicits anticonvulsant effect, protects the brain oxidative damage produced by seizures and exerts antidepressant action in mice. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2014, Volume: 24, Issue:8 Topics: Animals; Anticonvulsants; Antidepressive Agents; Brain Injuries; Disease Models, Animal; Flunitrazepam; Glutathione; Hindlimb Suspension; Lipid Peroxidation; Male; Maze Learning; Mice; Motor Activity; Pentylenetetrazole; Phenytoin; Seizures; Sodium-Potassium-Exchanging ATPase; Time Factors; Trimethadione; Veratrine	2014