phenytoin and tolbutamide

phenytoin has been researched along with tolbutamide in 80 studies

Research

Studies (80)

Timeframe	Studies, this research(%)	All Research%
pre-1990	41 (51.25)	18.7374
1990's	12 (15.00)	18.2507
2000's	12 (15.00)	29.6817
2010's	15 (18.75)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Aoyama, R; Jones, JP; Rao, S; Rettie, A; Schrag, M; Trager, WF	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Abraham, MH; Acree, WE; Ibrahim, A	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Campillo, NE; Guerra, A; Páez, JA	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Gozalbes, R; Pineda-Lucena, A	1
Ekins, S; Williams, AJ; Xu, JJ	1
Buttar, D; Colclough, N; Gerhardt, S; MacFaul, PA; Maskos, K; Phillips, SD; Plowright, A; Steinbacher, S; Steuber, H; Tam, K; Whittamore, P	1
Boriss, H; Braggio, S; Corbioli, S; Fontana, S; Helmdach, L; Longhi, R; Schiller, J; Vinco, F	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Bending, MR; Dollery, CT; Kahn, GC; Mucklow, JC	1
Birkett, DJ; Graham, GG; Pond, SM; Wade, DN	1
Hansen, M; Kristensen, M; Siersbaek-Nielsen, K; Skovsted, L	1
Müller-Oerlinghausen, B	1
Christensen, LK; Hansen, JM	1
Idle, JR; Sloan, TP; Smith, RL; Wakile, LA	1
Boquist, L	1
Birkett, DJ; Pond, SM	1
Hansen, JM; Kristensen, MB; Skovsted, L; Svendsen, TL	1
De Baere, H	1
Reidenberg, MM	1
Blackard, WG; Kikuchi, M; Rabinovitch, A; Renold, AE	1
Hansen, JM; Kampmann, J; Lumholtz, B; Siersbaek-Nielsen, K; Skovsted, L	1
Mols-Thürkow, I; Wesseling, H	1
Birkett, DJ; Doecke, CJ; McManus, ME; Miners, JO; Sansom, LN; Tassaneeyakul, W; Veronese, ME	1
Birkett, DJ; Doecke, CJ; Mackenzie, PI; McManus, ME; Miners, JO; Veronese, ME	1
Birkett, DJ; Doecke, CJ; McManus, ME; Miners, JO; Pond, SM; Sansom, LN; Veronese, ME	1
Damanhouri, Z; Gumbleton, M; Nicholls, PJ; Shaw, MA	1
Beech, E; Harrold, BP; Mathur, SV	1
Hanano, M; Iga, T; Sawada, Y; Sugiyama, Y	1
Bower, RH; Cohen, MS; Fidler, SM; Johnsonbaugh, RE; Sode, J	1
Christensen, LK; Skovsted, L	1
De Matteis, F	1
Freinkel, N; Knopp, RH; Scheinin, JC	1
Eipe, J	1
Gossel, TA; Mennear, JH	1
Johnsgård, M; Pedersen, AO	1
Mulder, G; Thurkow, I; Wesseling, H	1
Bacci, MC; Bianchi, C; Bonardi, G; Coppi, G; Molino, C; Tomasi, L; Vidi, A	1
Iber, FL; Kater, RM; Roggin, G; Tobon, F; Zieve, P	1
Brendel, K; Bressler, R; Kizer, JS; Vargas-Gordon, M	1
Ito, S	1
Meijer, DK; Thürkow, I; Wesseling, H	1
Abrams, WB; Reich, S; Solomon, HM; Spirt, N	1
Flessa, HC; Sigell, LT	1
Calhoun, FJ; Schrogie, JJ; Tolson, WW	1
Fariss, BL; Lutcher, CL	2
Hitzenberger, G	1
Eichelbaum, M	1
Papouchado, M; Reed, PI; Thornton, PC	1
Goldberg, DM	1
Ashforth, EI; Carlile, DJ; Chenery, R; Houston, JB	1
Desager, JP; Horsmans, Y; Kanyinda, JM	1
Birkett, DJ; Miners, JO; Pass, MC; Tassaneeyakul, W	1
Bradbury, A; Houston, JB; Worboys, PD	1
Horbach, GJ; Witkamp, RF; Zweers-Zeilmaker, WM	1
Birkett, DJ; Miners, JO	1
Abel, SM; Hyland, R; Jones, BC; Smith, DA	1
Bayliss, MK; Carlile, DJ; Hakooz, N; Houston, JB	1
Ball, DE; Kamali, F; McLaughlin, WS; Seymour, RA	1
Rodrigues, AD; Shou, M; Tang, C	1
Lin, JH; Lin, Y; Rodrigues, AD; Tang, C	1
BURNS, JJ	1
Gorman, LA; Kumar, V; Rock, DA; Tracy, TS; Wahlstrom, JL; Warren, CJ	1
Brown, HS; Chadwick, A; Houston, JB	1
Al Balushi, AA; Gordon, R	1
Cai, JP; Chen, LG; Dai, DP; Hu, GX; Sun, LR; Wang, Z; Xiong, JH; Zhu, Y	1

Reviews

11 review(s) available for phenytoin and tolbutamide

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Drug interactions with oral sulphonylurea hypoglycaemic drugs. Drugs, 1977, Volume: 13, Issue:1 Topics: Allopurinol; Analgesics; Anticoagulants; Chloramphenicol; Chlorpropamide; Disulfiram; Drug Interactions; Ethanol; Glyburide; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Kinetics; Monoamine Oxidase Inhibitors; Novobiocin; Phenylbutazone; Phenytoin; Probenecid; Propranolol; Rifampin; Sulfonamides; Sulfonylurea Compounds; Tolbutamide	1977
Drug metabolism in uremia. Clinical nephrology, 1975, Volume: 4, Issue:3 Topics: Acetohexamide; Animals; Antipyrine; Humans; Hydrolysis; Lipid Metabolism; Microsomes, Liver; Oxidation-Reduction; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Procainamide; Rats; Tolbutamide; Uremia; Vitamin D	1975
Prediction of the disposition of nine weakly acidic and six weakly basic drugs in humans from pharmacokinetic parameters in rats. Journal of pharmacokinetics and biopharmaceutics, 1985, Volume: 13, Issue:5 Topics: Animals; Antipyrine; Barbiturates; Biological Availability; Chlorpromazine; Diazepam; Drug Evaluation; Female; Half-Life; Humans; Kinetics; Male; Metabolic Clearance Rate; Pentazocine; Pharmaceutical Preparations; Phenylbutazone; Phenytoin; Propranolol; Quinidine; Rats; Species Specificity; Tissue Distribution; Tolbutamide; Valproic Acid; Warfarin	1985
Toxic hepatic porphyrias. Seminars in hematology, 1968, Volume: 5, Issue:4 Topics: Alcoholism; Antifungal Agents; Chemical and Drug Induced Liver Injury; Chlorpropamide; Hexachlorocyclohexane; Humans; Liver; Phenobarbital; Phenytoin; Porphyrias; Sulfanilamides; Sulfones; Tolbutamide; Turkey	1968
Drugs affecting therapy with anticoagulants. The Medical clinics of North America, 1972, Volume: 56, Issue:1 Topics: Anticoagulants; Chloramphenicol; Clofibrate; Contraceptives, Oral; Coumarins; Diuretics; Drug Interactions; Drug Synergism; Drug-Related Side Effects and Adverse Reactions; Estrogens; Ethanol; Heparin; Humans; Hypnotics and Sedatives; Phenylbutazone; Phenytoin; Salicylates; Thyroxine; Tolbutamide; Vitamin K	1972
[Recent data on thyroxine-binding protein]. Saishin igaku. Modern medicine, 1967, Volume: 22, Issue:7 Topics: Androgens; Animals; Anticoagulants; Barbiturates; Bilirubin; Carbon Dioxide; Chemical Phenomena; Chemistry, Physical; Diuretics; Estrogens; Glucocorticoids; Humans; Novobiocin; Penicillins; Phenylbutazone; Phenytoin; Salicylates; Thyroid Diseases; Thyroxine; Thyroxine-Binding Proteins; Tolbutamide	1967
The expanding role of microsomal enzyme induction, and its implications for clinical chemistry. Clinical chemistry, 1980, Volume: 26, Issue:6 Topics: Acetaminophen; Alcoholism; Animals; Antipyrine; Aryl Hydrocarbon Hydroxylases; Electron Transport; Energy Intake; Enzyme Induction; Epilepsy; Female; Humans; Male; Microsomes, Liver; Pharmacology; Phenobarbital; Phenylbutazone; Phenytoin; Smoking; Tolbutamide; Warfarin	1980
Cytochrome P4502C9: an enzyme of major importance in human drug metabolism. British journal of clinical pharmacology, 1998, Volume: 45, Issue:6 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Repression; Humans; Pharmaceutical Preparations; Phenytoin; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Substrate Specificity; Sulfonamides; Tolbutamide; Torsemide; Warfarin	1998
Human cytochrome P450s: selectivity and measurement in vivo. Xenobiotica; the fate of foreign compounds in biological systems, 1998, Volume: 28, Issue:12 Topics: Aryl Hydrocarbon Hydroxylases; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; Isoenzymes; Mixed Function Oxygenases; Phenytoin; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Structure-Activity Relationship; Tolbutamide	1998
IMPLICATIONS ON ENZYME INDUCTION FOR DRUG THERAPY. The American journal of medicine, 1964, Volume: 37 Topics: Animals; Benzopyrenes; Cyclizine; Dicumarol; Diphenhydramine; Dogs; Drug Therapy; Enzyme Induction; Enzymes; Glutethimide; Hexobarbital; Liver; Meprobamate; Metabolism; Pharmacology; Phenobarbital; Phenylbutazone; Phenytoin; Probenecid; Rats; Research; Tolbutamide; Toxicology; Zoxazolamine	1964

Trials

3 trial(s) available for phenytoin and tolbutamide

Article	Year
The effect of different oral anticoagulants on diphenylhydantoin (DPH) and tolbutamide metabolism. Acta medica Scandinavica, 1976, Volume: 199, Issue:6 Topics: Coumarins; Dicumarol; Half-Life; Humans; Phenindione; Phenprocoumon; Phenytoin; Tolbutamide; Warfarin	1976
Increased rate of clearance of drugs from the circulation of alcoholics. The American journal of the medical sciences, 1969, Volume: 258, Issue:1 Topics: Alcoholism; Clinical Trials as Topic; Ethanol; Humans; Liver; Microsomes; Phenytoin; Tolbutamide; Warfarin	1969
Limited value of the urinary phenytoin metabolic ratio for the assessment of cytochrome P4502C9 activity in vivo. British journal of clinical pharmacology, 1996, Volume: 42, Issue:6 Topics: Adult; Anticonvulsants; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Biomarkers; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Female; Humans; Hypoglycemic Agents; Male; Phenytoin; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Tolbutamide	1996

Other Studies

66 other study(ies) available for phenytoin and tolbutamide

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
A refined 3-dimensional QSAR of cytochrome P450 2C9: computational predictions of drug interactions. Journal of medicinal chemistry, 2000, Jul-27, Volume: 43, Issue:15 Topics: Aryl Hydrocarbon Hydroxylases; Binding Sites; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Ligands; Models, Biological; Models, Molecular; Protein Binding; Reproducibility of Results; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Structure-Activity Relationship; Sulfaphenazole; Sulfonamides; Warfarin	2000
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs. European journal of medicinal chemistry, 2008, Volume: 43, Issue:3 Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization	2008
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
QSAR-based solubility model for drug-like compounds. Bioorganic & medicinal chemistry, 2010, Oct-01, Volume: 18, Issue:19 Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions. Bioorganic & medicinal chemistry, 2010, Nov-01, Volume: 18, Issue:21 Topics: Binding Sites; Crystallography, X-Ray; Drug Interactions; Humans; Pharmaceutical Preparations; Protein Binding; Protein Structure, Tertiary; Serum Albumin; Spectrometry, Fluorescence	2010
Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2 Topics: Absorption; Albumins; Animals; Brain; Brain Chemistry; Cell Membrane; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; In Vitro Techniques; Lipids; Male; Microdialysis; Pharmaceutical Preparations; Protein Binding; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine; Tissue Distribution	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
Drug concentration in saliva. Clinical pharmacology and therapeutics, 1978, Volume: 24, Issue:5 Topics: Adolescent; Adult; Aged; Antipyrine; Chlorpropamide; Humans; Hydrogen-Ion Concentration; Male; Meperidine; Middle Aged; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Propranolol; Protein Binding; Saliva; Tolbutamide	1978
Effects of tricyclic antidepressants on drug metabolism. Clinical pharmacology and therapeutics, 1975, Volume: 18, Issue:2 Topics: Adult; Amitriptyline; Dicumarol; Half-Life; Humans; Kinetics; Male; Nortriptyline; Pharmaceutical Preparations; Phenytoin; Time Factors; Tolbutamide; Warfarin	1975
[Effects of combination of anti-epileptic drugs]. Bibliotheca psychiatrica, 1975, Issue:151 Topics: Adrenergic beta-Antagonists; Anticonvulsants; Benzodiazepines; Carbamazepine; Digitoxin; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Lithium; Phenobarbital; Phenytoin; Primidone; Thiazines; Tolbutamide; Tranquilizing Agents	1975
Application of the phenotyped panel approach to the detection of polymorphism of drug oxidation in man [proceedings]. British journal of pharmacology, 1979, Volume: 66, Issue:3 Topics: Humans; Kinetics; Oxidation-Reduction; Pharmaceutical Preparations; Phenotype; Phenytoin; Tolbutamide	1979
Differences in the blood glucose response of mice to alloxan and alloxan-inhibiting compounds. Acta endocrinologica, 1979, Volume: 92, Issue:4 Topics: Acetazolamide; Alloxan; Animals; Bicarbonates; Blood Glucose; Deoxy Sugars; Diabetes Mellitus, Experimental; Eating; Hydroxymercuribenzoates; Lactates; Leucine; Mannoheptulose; Mice; Mice, Inbred C57BL; Phenytoin; Starvation; Tolbutamide	1979
Metabolic drug interactions--a critical review. The Medical journal of Australia, 1975, May-31, Volume: 1, Issue:22 Topics: Alcohol Oxidoreductases; Aldehyde Oxidoreductases; Anticoagulants; Barbiturates; Chloral Hydrate; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Depression, Chemical; Disulfiram; Drug Interactions; Enzyme Induction; Ethanol; Glucuronosyltransferase; Humans; Liver; Microsomes, Liver; Phenytoin; Polycyclic Compounds; Tolbutamide	1975
The influence of disulfiram on the half life and metabolic clearance rate of diphenylhydantoin and tolbtamide in man. European journal of clinical pharmacology, 1976, Mar-22, Volume: 09, Issue:5-6 Topics: Adult; Aged; Disulfiram; Drug Interactions; Female; Half-Life; Humans; Kinetics; Male; Metabolic Clearance Rate; Middle Aged; Phenytoin; Tolbutamide	1976
[Alcohol and drugs]. Tijdschrift voor gastro-enterologie, 1976, Volume: 19, Issue:2 Topics: Acetaldehyde; Acetyl Coenzyme A; Anesthetics; Barbiturates; Drug Interactions; Ethanol; Humans; Hypnotics and Sedatives; Intestinal Absorption; Isoniazid; Pharmaceutical Preparations; Phenytoin; Tolbutamide; Warfarin	1976
An effect of hyposmolarity on insulin release in vitro. The American journal of physiology, 1975, Volume: 228, Issue:3 Topics: Amiloride; Amylases; Animals; Atropine; Calcium; Choline; Colchicine; Diazoxide; Epinephrine; Glucagon; Glucose; Hypotonic Solutions; Imidazoles; In Vitro Techniques; Insulin; Insulin Secretion; Male; Osmolar Concentration; Ouabain; Pancreas; Phentolamine; Phenytoin; Propranolol; Rats; Sorbitol; Tolbutamide; Trypsin Inhibitors; Vinblastine	1975
Sulfamethizole-induced inhibition of diphenlhydantoin, tolbutamide, and warfarin metabolism. Clinical pharmacology and therapeutics, 1975, Volume: 17, Issue:6 Topics: Depression, Chemical; Half-Life; Humans; Kinetics; Metabolic Clearance Rate; Phenytoin; Sulfamethizole; Sulfathiazoles; Tolbutamide; Ultrafiltration; Warfarin	1975
Interaction of diphenylhydantoin (DPH) and tolbutamide in man. European journal of clinical pharmacology, 1975, Volume: 8, Issue:1 Topics: Adult; Animals; Blood Proteins; Drug Interactions; Epilepsy; Female; Humans; In Vitro Techniques; Male; Middle Aged; Phenytoin; Protein Binding; Rats; Tolbutamide	1975
Co-regulation of phenytoin and tolbutamide metabolism in humans. British journal of clinical pharmacology, 1992, Volume: 34, Issue:6 Topics: Adult; Blood Proteins; Chromatography, High Pressure Liquid; Drug Interactions; Female; Humans; Male; Phenytoin; Protein Binding; Tolbutamide	1992
Tolbutamide and phenytoin hydroxylations by cDNA-expressed human liver cytochrome P4502C9. Biochemical and biophysical research communications, 1991, Mar-29, Volume: 175, Issue:3 Topics: Animals; Base Sequence; Cell Line; Cytochrome P-450 Enzyme System; DNA; Gene Library; Humans; Hydroxylation; Kinetics; Liver; Microsomes, Liver; Molecular Sequence Data; Oligonucleotide Probes; Phenytoin; Recombinant Proteins; Substrate Specificity; Sulfaphenazole; Tolbutamide; Transfection	1991
Relationship between phenytoin and tolbutamide hydroxylations in human liver microsomes. British journal of clinical pharmacology, 1991, Volume: 31, Issue:2 Topics: Binding, Competitive; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Hydroxylation; Immunoglobulin G; In Vitro Techniques; Kinetics; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Phenytoin; Sulfaphenazole; Tolbutamide	1991
In-vivo effects of itraconazole on hepatic mixed-function oxidase. The Journal of antimicrobial chemotherapy, 1988, Volume: 21, Issue:2 Topics: Animals; Anticonvulsants; Cytochrome P-450 Enzyme System; Dicumarol; Female; Itraconazole; Ketoconazole; Liver; Male; Mice; Mixed Function Oxygenases; Paralysis; Phenytoin; Rats; Tolbutamide	1988
Phenytoin toxicity produced by tolbutamide. BMJ (Clinical research ed.), 1988, Dec-17, Volume: 297, Issue:6663 Topics: Drug Interactions; Female; Humans; Middle Aged; Phenytoin; Tolbutamide	1988
Inhibition of insulin release by diphenylhydantoin and diazoxide in a patient with benign insulinoma. Lancet (London, England), 1973, Jan-06, Volume: 1, Issue:7793 Topics: Adenoma, Islet Cell; Aged; Depression, Chemical; Diazoxide; Glucose; Humans; Insulin; Insulin Secretion; Male; Pancreatic Neoplasms; Phenytoin; Tolbutamide	1973
Inhibition of drug metabolism by chloramphenicol. Lancet (London, England), 1969, Dec-27, Volume: 2, Issue:7635 Topics: Aged; Biotransformation; Carbon Isotopes; Chloramphenicol; Chromatography, Thin Layer; Dicumarol; Humans; Hypoglycemia; Male; Parkinson Disease; Phenytoin; Tolbutamide	1969
Diphenylhydantoin and an insulin-secreting islet adenoma. Archives of internal medicine, 1972, Volume: 130, Issue:6 Topics: Adenoma, Islet Cell; Adult; Blood Glucose; Epilepsy, Tonic-Clonic; Glucagon; Humans; Insulin; Insulin Secretion; Leucine; Male; Nitrogen; Pancreas; Phenytoin; Tolbutamide	1972
Interactions between diphenylhydantoin and tolbutamide in mice. Toxicology and applied pharmacology, 1973, Volume: 24, Issue:2 Topics: Adrenal Glands; Animals; Blood Glucose; Carbohydrate Metabolism; Drug Interactions; Electroshock; Epinephrine; Glucose Tolerance Test; Hyperglycemia; In Vitro Techniques; Insulin; Insulin Antagonists; Insulin Secretion; Lethal Dose 50; Male; Mice; Pancreas; Phenytoin; Time Factors; Tolbutamide	1973
[The consequence of the preparation factors for the effect of the drug]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1973, Apr-10, Volume: 93, Issue:10 Topics: Absorption; Administration, Oral; Biopharmaceutics; Capsules; Chemistry, Pharmaceutical; Chloramphenicol; Digoxin; Humans; Nitrofurantoin; Pharmaceutical Preparations; Pharmaceutical Vehicles; Phenytoin; Structure-Activity Relationship; Suppositories; Tablets; Tablets, Enteric-Coated; Tetracycline; Time Factors; Tolbutamide	1973
Effect of sulphonylureas (tolazamide, tolbutamide and chlorpropamide) on the metabolism of diphenylhydantoin in the rat. Biochemical pharmacology, 1973, Dec-01, Volume: 22, Issue:23 Topics: Animals; Brain; Carbon Radioisotopes; Chlorpropamide; Chromatography, Thin Layer; Dose-Response Relationship, Drug; Half-Life; Hydroxylation; In Vitro Techniques; Liver; Male; Phenytoin; Rats; Time Factors; Tolazamide; Tolbutamide	1973
Experimental models for the in vivo evaluation of enzyme induction properties of drugs. Arzneimittel-Forschung, 1973, Volume: 23, Issue:12 Topics: Acetanilides; Amides; Aminopyrine; Amphetamine; Aniline Compounds; Animals; Central Nervous System; Codeine; Cyclohexanecarboxylic Acids; Drug Evaluation, Preclinical; Enzyme Activation; Enzyme Induction; Hexobarbital; Male; Meperidine; Mice; Oxotremorine; Pentobarbital; Phenacetin; Phenytoin; Rabbits; Rats; Strychnine; Tolbutamide; Tremorine; Zoxazolamine	1973
The in vitro inhibition of insulin secretion by diphenylhydantoin. The Journal of clinical investigation, 1970, Volume: 49, Issue:10 Topics: Animals; Anticonvulsants; Buffers; Glucose; Hydantoins; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Methacholine Compounds; Ouabain; Pancreas; Pentobarbital; Phenytoin; Potassium; Rats; Tolbutamide	1970
Estimation of phenytoin in body fluids in the presence of sulphonyl urea compounds. Clinica chimica acta; international journal of clinical chemistry, 1972, Volume: 37 Topics: Animals; Benzophenones; Body Fluids; Brain Chemistry; Chlorpropamide; Methods; Phenytoin; Potassium Permanganate; Rats; Spectrophotometry; Sulfonylurea Compounds; Tolazamide; Tolbutamide	1972
Non-equivalent preparations of the same drug. Drug and therapeutics bulletin, 1971, Aug-13, Volume: 9, Issue:17 Topics: Chloramphenicol; Dosage Forms; Humans; Nitrofurantoin; Oxytetracycline; Pharmaceutical Preparations; Phenindione; Phenobarbital; Phenylbutazone; Phenytoin; Tetracycline; Therapeutic Equivalency; Tolbutamide; Warfarin	1971
Interactions between digitoxin and other drugs in vitro and in vivo. Annals of the New York Academy of Sciences, 1971, Jul-06, Volume: 179 Topics: Binding Sites; Cell Membrane Permeability; Chemical Phenomena; Chemistry; Clofibrate; Digitoxin; Digoxin; Drug Antagonism; Enzyme Induction; Erythrocytes; Humans; Microsomes, Liver; Phenobarbital; Phenylbutazone; Phenytoin; Protein Binding; Radioisotopes; Rubidium; Serum Albumin; Sulfadimethoxine; Tolbutamide; Tritium; Warfarin	1971
Drug interactions with anticoagulants. JAMA, 1970, Dec-14, Volume: 214, Issue:11 Topics: Acetaminophen; Animals; Anti-Bacterial Agents; Anticoagulants; Ascorbic Acid; Barbiturates; Blood Coagulation; Blood Coagulation Tests; Cardiac Glycosides; Chlordiazepoxide; Chlorothiazide; Contraceptives, Oral; Diazepam; Dogs; Drug Antagonism; Epinephrine; Ethchlorvynol; Glucagon; Haloperidol; Humans; Methylphenidate; Phenethylamines; Phenylbutazone; Phenytoin; Quinolines; Salicylates; Steroids; Substance-Related Disorders; Tetanus Toxoid; Tolbutamide; Xanthines	1970
Effects of various drugs on the uterotropic response to mestranol and norethynodrel in the rat. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1971, Volume: 136, Issue:1 Topics: Aminosalicylic Acids; Animals; Chlorpromazine; Drug Synergism; Female; Imipramine; Mestranol; Norethynodrel; Organ Size; Phenobarbital; Phenylbutazone; Phenytoin; Proadifen; Rats; Scopolamine; Tolbutamide; Uterus	1971
Diphenylhydantoin-induced hyperglycemia and impaired insulin release. Effect of dosage. Diabetes, 1971, Volume: 20, Issue:3 Topics: Adult; Blood Glucose; Female; Glucose Tolerance Test; Humans; Hyperglycemia; Insulin; Insulin Secretion; Phenytoin; Tolbutamide	1971
Diphenylhdantoin-induced hyperglycemia and impaired insulin release. Effect of dosage. Diabetes, 1971, Volume: 20, Issue:3 Topics: Adult; Blood Glucose; Female; Glucose Tolerance Test; Humans; Hyperglycemia; Insulin; Insulin Secretion; Phenytoin; Tolbutamide	1971
[Drug interactions as a cause for iatrogenic diseases in the aged. A tabulated presentation]. Aktuelle Gerontologie, 1983, Volume: 13, Issue:5 Topics: Aged; Alcohol Drinking; Binding, Competitive; Blood Proteins; Drug Interactions; Enzyme Induction; Ethanol; Humans; Iatrogenic Disease; Phenytoin; Protein Binding; Receptors, Drug; Tissue Distribution; Tolbutamide; Warfarin	1983
Polymorphic drug oxidation in humans. Federation proceedings, 1984, May-15, Volume: 43, Issue:8 Topics: Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Debrisoquin; Humans; Mephenytoin; Microsomes, Liver; Oxidation-Reduction; Pharmaceutical Preparations; Phenacetin; Phenformin; Phenytoin; Polymorphism, Genetic; Sparteine; Tolbutamide	1984
Carbenoxolone interactions in man--preliminary report. Scandinavian journal of gastroenterology. Supplement, 1980, Volume: 65 Topics: Carbenoxolone; Chlorpropamide; Drug Interactions; Glycyrrhetinic Acid; Half-Life; Humans; Phenytoin; Protein Binding; Stomach Ulcer; Tolbutamide; Warfarin	1980
Prediction of in vivo disposition from in vitro systems: clearance of phenytoin and tolbutamide using rat hepatic microsomal and hepatocyte data. The Journal of pharmacology and experimental therapeutics, 1995, Volume: 274, Issue:2 Topics: Animals; Liver; Male; Metabolic Clearance Rate; Microsomes, Liver; Phenytoin; Rats; Rats, Sprague-Dawley; Tolbutamide	1995
Relationship between mephenytoin, phenytoin and tolbutamide hydroxylations in healthy African subjects. Pharmacology & toxicology, 1996, Volume: 78, Issue:2 Topics: Adult; Democratic Republic of the Congo; Female; Humans; Hydroxylation; Male; Mephenytoin; Phenytoin; Tolbutamide	1996
Kinetics of drug metabolism in rat liver slices. III. Relationship between metabolic clearance and slice uptake rate. Drug metabolism and disposition: the biological fate of chemicals, 1997, Volume: 25, Issue:4 Topics: Animals; Caffeine; Diazepam; In Vitro Techniques; Liver; Male; Ondansetron; Pharmacokinetics; Phenytoin; Rats; Rats, Sprague-Dawley; Tolbutamide	1997
Differential inhibitory effects of phenytoin, diclofenac, phenylbutazone and a series of sulfonamides on hepatic cytochrome P4502C activity in vitro, and correlation with some molecular descriptors in the dwarf goat (Caprus hircus aegagrus). Xenobiotica; the fate of foreign compounds in biological systems, 1997, Volume: 27, Issue:8 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diclofenac; Enzyme Inhibitors; Female; Goats; Hydroxylation; Kinetics; Liver; Microsomes, Liver; Phenylbutazone; Phenytoin; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Sulfaphenazole; Sulfonamides; Tolbutamide	1997
Microsomal prediction of in vivo clearance of CYP2C9 substrates in humans. British journal of clinical pharmacology, 1999, Volume: 47, Issue:6 Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Humans; Metabolic Clearance Rate; Microsomes, Liver; Phenytoin; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Tolbutamide	1999
Phenytoin metabolism to 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPPH) in man, cat and rat in vitro and in vivo, and susceptibility to phenytoin-induced gingival overgrowth. Journal of periodontal research, 1999, Volume: 34, Issue:3 Topics: Adult; Aged; Animals; Anticonvulsants; Area Under Curve; Biotransformation; Cats; Chlorophyll; Chromatography, High Pressure Liquid; Epilepsy; Female; Gingival Overgrowth; Humans; Hydroxylation; Liver; Male; Microsomes; Middle Aged; Phenytoin; Photosensitizing Agents; Rats; Rats, Wistar; Species Specificity; Statistics, Nonparametric; Sulfaphenazole; Tolbutamide	1999
Substrate-dependent effect of acetonitrile on human liver microsomal cytochrome P450 2C9 (CYP2C9) activity. Drug metabolism and disposition: the biological fate of chemicals, 2000, Volume: 28, Issue:5 Topics: Acetonitriles; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Blocking; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Celecoxib; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diclofenac; Enzyme Inhibitors; Humans; Hypoglycemic Agents; In Vitro Techniques; Microsomes, Liver; Phenotype; Phenytoin; Pyrazoles; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Sulfonamides; Tolbutamide	2000
Effect of albumin on phenytoin and tolbutamide metabolism in human liver microsomes: an impact more than protein binding. Drug metabolism and disposition: the biological fate of chemicals, 2002, Volume: 30, Issue:6 Topics: Humans; In Vitro Techniques; Microsomes, Liver; Phenytoin; Protein Binding; Serum Albumin, Bovine; Tolbutamide	2002
CYP2C9 inhibition: impact of probe selection and pharmacogenetics on in vitro inhibition profiles. Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:12 Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Diclofenac; Enzyme Inhibitors; Flurbiprofen; Genotype; In Vitro Techniques; Pharmacogenetics; Phenytoin; Piroxicam; Tolbutamide; Warfarin	2006
Use of isolated hepatocyte preparations for cytochrome P450 inhibition studies: comparison with microsomes for Ki determination. Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:11 Topics: Animals; Catalysis; Cells, Cultured; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Enzyme Inhibitors; Fluconazole; Fluoxetine; Fluvoxamine; Hepatocytes; Ketoconazole; Kinetics; Male; Miconazole; Microsomes, Liver; Midazolam; Phenytoin; Quinine; Rats; Rats, Sprague-Dawley; Tolbutamide	2007
A label-free untethered approach to single-molecule protein binding kinetics. Nano letters, 2014, Oct-08, Volume: 14, Issue:10 Topics: Anticonvulsants; Equipment Design; Humans; Hypoglycemic Agents; Kinetics; Models, Molecular; Optical Tweezers; Phenytoin; Protein Binding; Serum Albumin; Tolbutamide	2014
In vitro metabolism of phenytoin in 36 CYP2C9 variants found in the Chinese population. Chemico-biological interactions, 2016, Jun-25, Volume: 253 Topics: Alleles; Asian People; Bosentan; Carbazoles; Carvedilol; China; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C9; Humans; Kinetics; Phenytoin; Polymorphism, Genetic; Propanolamines; Sulfonamides; Tandem Mass Spectrometry; Tolbutamide	2016