phenytoin has been researched along with tetrodotoxin in 57 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (49.12) | 18.7374 |
| 1990's | 12 (21.05) | 18.2507 |
| 2000's | 11 (19.30) | 29.6817 |
| 2010's | 6 (10.53) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fukuda, H; Kontani, H; Kudo, Y | 1 |
| De Weer, P; McKinney, L; Perry, JG | 1 |
| Richelson, E; Tuttle, JB | 1 |
| Ferrendelli, JA; Kinscherf, DA | 1 |
| Hertz, L | 1 |
| Josephson, I; Sperelakis, N | 1 |
| Dalla Volta, S; Ferrari, M; Furlanut, M; Melacini, P | 1 |
| Akaike, N; Kameda, H; Kataoka, M; Takahashi, K; Ueno, S | 1 |
| Azzidani, AM; Magyar, K; Török, TL; Tóth, PT; Tóthfalusi, L | 1 |
| Powis, DA; Török, TL | 1 |
| Marban, E; Tomaselli, GF; Yellen, G | 1 |
| Akaike, N; Takahashi, K; Wakamori, M | 1 |
| Logan, SD; McDermott, EE | 1 |
| Drouva, SV; Kordon, C; Laplante, E | 1 |
| McKinney, LC | 1 |
| Kiss, A; Pincus, JH | 1 |
| Izumi, F; Kobayashi, H; Wada, A; Yanagihara, N | 1 |
| David, G; Selzer, ME; Yaari, Y | 1 |
| Tanz, RD | 1 |
| Glaser, GE; Grove, I; Marino, BB; Pincus, JH | 1 |
| Doherty, JD; Matsumura, F | 1 |
| Lee, S; Pincus, JH | 1 |
| Watanabe, Y | 1 |
| Iida, Y; Sano, T; Sato, S; Suzuki, F | 1 |
| Mizukami, K; Ogura, Y | 1 |
| Narahashi, T | 1 |
| De Weer, P | 1 |
| Ferrendelli, JA | 1 |
| Connors, BW | 1 |
| Nencini, P; Pasquarelli, V | 1 |
| Daniels-McQueen, S; Ferrendelli, JA | 1 |
| Burke, SP; Taylor, CP; Weber, ML | 1 |
| Izumi, F; Mita, T; Murai, Y; Sashihara, S; Yanagihara, N | 1 |
| Taylor, CP; Weber, ML | 1 |
| McLean, MJ; Wamil, AW | 1 |
| Huang, CS; Nagata, K; Narahashi, T; Song, JH; Yeh, JZ | 1 |
| Elliott, JR; Rush, AM | 1 |
| Borosky, S; Marcoux, FW; Probert, AW; Taylor, CP | 1 |
| Stamford, JA; Toner, CC | 1 |
| Hagan, RM; Higgins, GA; Kirkby, D; Southam, E | 1 |
| Brumberg, JC; McCormick, DA; Nowak, LG | 1 |
| Cater, HL; Clare, JJ; Dale, TJ; John, VH; Peakman, TC; Xie, X | 1 |
| Alroy, G; Kirson, ED; Su, H; Yaari, Y | 1 |
| Brodie, MJ; Santangeli, S; Sills, GJ; Thompson, GG | 1 |
| Altun, S; Berridge, RJ; Djamgoz, MB; Fraser, SP; Manning, EA; Mizal, J; Raza, M; Salvador, V | 1 |
| Ishizuka, S; Jinno, S; Kosaka, T | 1 |
| Manis, PB; Molitor, SC; Wu, H | 1 |
| Black, JA; Craner, MJ; Cuzner, ML; Damarjian, TG; Hains, BC; Liu, S; Lo, AC; Newcombe, J; Waxman, SG | 1 |
| Huttu, K; Kaila, K; Sipilä, ST; Voipio, J | 1 |
| Castro-Alamancos, MA; Rigas, P; Tawara-Hirata, Y | 1 |
| Black, JA; Liu, S; Waxman, SG | 1 |
| Feuerstein, TJ; Freiman, TM; Kammerer, M; Rassner, MP | 1 |
| Aldana, BI; Chiu, LM; Guarneros, A; Sanchez-Tafolla, BM; Sitges, M | 1 |
| Brackenbury, WJ; Khajah, MA; Luqmani, YA; Mohammed, FH; Yang, M | 1 |
| Barker, BS; Hollander, RM; Meisler, MH; Ottolini, M; Patel, MK; Wagnon, JL | 1 |
| French, CR; Hill-Yardin, EL; Kularathna, PK; Mackie, EJ; Milligan, CJ; O'Brien, TJ; Pagel, CN; Petrou, S; Petty, SJ; Richards, KL; Todaro, M; Wark, JD | 1 |
| Franke, H; Illes, P; Khan, MT; Liu, J; Nerlich, J; Tang, Y | 1 |
2 review(s) available for phenytoin and tetrodotoxin
| Article | Year |
|---|---|
Phenytoin: blockage of resting sodium channels.
Topics: Action Potentials; Animals; Calcium; Humans; In Vitro Techniques; Ion Channels; Membrane Potentials; Ouabain; Phenytoin; Sodium; Sodium-Potassium-Exchanging ATPase; Tetrodotoxin | 1980 |
Phenytoin: cyclic nucleotide regulation in the brain.
Topics: Animals; Brain Chemistry; Cyclic AMP; Cyclic GMP; Humans; Phenytoin; Potassium; Seizures; Tetrodotoxin | 1980 |
55 other study(ies) available for phenytoin and tetrodotoxin
| Article | Year |
|---|---|
[Effect of drugs affecting sodium permeability on the muscle spindle of frogs].
Topics: Aconitine; Animals; Cell Membrane Permeability; Chlorpromazine; In Vitro Techniques; Muscle Spindles; Neural Conduction; Phenytoin; Polycyclic Compounds; Procaine; Rana catesbeiana; Sodium; Tetrodotoxin; Toxins, Biological; Veratridine | 1976 |
The cellular mode of action of the anti-epileptic drug 5,5-diphenylhydantoin.
Topics: Animals; Anura; Axons; Biological Transport; Cell Membrane Permeability; Decapodiformes; In Vitro Techniques; Membrane Potentials; Muscles; Phenytoin; Potassium; Rana pipiens; Sodium; Tetrodotoxin; Veratridine | 1978 |
Phenytoin action on the excitable membrane of mouse neuroblastoma.
Topics: Action Potentials; Animals; Calcium; Cells, Cultured; Membrane Potentials; Membranes; Mice; Neoplasms, Experimental; Neuroblastoma; Neurons; Phenytoin; Tetrodotoxin; Time Factors | 1979 |
Similar effects of phenytoin and tetrodotoxin on cyclic nucleotid regulation in depolarized brain tissue.
Topics: Animals; Brain; Drug Interactions; Glutamates; In Vitro Techniques; Mice; Nucleotides, Cyclic; Ouabain; Phenytoin; Potassium; Tetrodotoxin; Veratridine | 1978 |
Drug-induced alterations of ion distribution at the cellular level of the central nervous system.
Topics: Acetazolamide; Anesthetics, Local; Animals; Barbiturates; Central Nervous System; Chlorpromazine; Ethanol; Extracellular Space; Humans; Ions; Lithium; Magnesium; Neuroglia; Neurons; Ouabain; Phenytoin; Protoveratrines; Pyridines; Tetrodotoxin | 1977 |
Local anesthetic blockade of Ca2+ -mediated action potentials in cardiac muscle.
Topics: Action Potentials; Anesthetics, Local; Animals; Calcium; Cells, Cultured; Chick Embryo; Cocaine; Heart; In Vitro Techniques; Lidocaine; Phenytoin; Procaine; Tetrodotoxin | 1976 |
Effects of quinidine and diphenylhydantoin on membrane resistance in smooth muscle.
Topics: Animals; Colon; Electric Conductivity; Guinea Pigs; In Vitro Techniques; Membranes; Metals; Muscle, Smooth; Phenytoin; Quinidine; Tetrodotoxin | 1975 |
Effects of Ca2+ antagonists and antiepileptics on tetrodotoxin-sensitive Ca(2+)-conducting channels in isolated rat hippocampal CA1 neurons.
Topics: Animals; Anticonvulsants; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Diltiazem; Dizocilpine Maleate; Dose-Response Relationship, Drug; Flunarizine; Hippocampus; Kinetics; Neurons; Nicardipine; Phenobarbital; Phenytoin; Pyramidal Tracts; Rats; Rats, Wistar; Sodium; Tetrodotoxin; Valproic Acid; Verapamil | 1992 |
Dependence of release of [3H]noradrenaline from rabbit pulmonary artery on internal sodium.
Topics: Animals; Dose-Response Relationship, Drug; Electric Stimulation; Female; In Vitro Techniques; Male; Manganese; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phenytoin; Pulmonary Artery; Rabbits; Sodium; Sodium-Potassium-Exchanging ATPase; Tetrodotoxin | 1992 |
Catecholamine release from bovine chromaffin cells: the role of sodium-calcium exchange in ouabain-evoked release.
Topics: Adrenal Glands; Animals; Calcium; Carrier Proteins; Catecholamines; Cattle; Cells, Cultured; Chromaffin System; Norepinephrine; Ouabain; Phenytoin; Sodium; Sodium-Calcium Exchanger; Sodium-Potassium-Exchanging ATPase; Tetrodotoxin | 1990 |
Sodium channels from human brain RNA expressed in Xenopus oocytes. Basic electrophysiologic characteristics and their modification by diphenylhydantoin.
Topics: Animals; Brain; Electrophysiology; Female; Humans; Microinjections; Neurons; Oocytes; Phenytoin; RNA; Sodium Channels; Tetrodotoxin; Xenopus | 1989 |
Hippocampal CA1 pyramidal cells of rats have four voltage-dependent calcium conductances.
Topics: Amiloride; Animals; Calcium Channel Blockers; Calcium Channels; Electric Conductivity; Gadolinium; Hippocampus; Kinetics; Lanthanum; Neurons; Nicardipine; Octanols; Phenytoin; Pyramidal Tracts; Rats; Tetrodotoxin | 1989 |
Inhibition of agonist-stimulated inositol lipid metabolism by the anticonvulsant carbamazepine in rat hippocampus.
Topics: Animals; Carbachol; Carbamazepine; Hippocampus; Histamine; In Vitro Techniques; Inositol; Lipid Metabolism; Male; Phenytoin; Rats; Rats, Inbred Strains; Sodium Channels; Tetrodotoxin; Veratrine | 1989 |
Progesterone-induced LHRH release in vitro is an estrogen--as well as Ca++- and calmodulin-dependent secretory process.
Topics: Animals; Calcium; Calmodulin; Castration; Culture Techniques; Estradiol; Female; Gonadotropin-Releasing Hormone; Hypothalamus, Middle; Ion Channels; Phenytoin; Progesterone; Rats; Rats, Inbred Strains; Tetrodotoxin; Trifluoperazine | 1985 |
Diphenylhydantoin reduces veratridine-induced sodium permeability in frog skeletal muscle.
Topics: Animals; Cell Membrane Permeability; Ion Channels; Magnesium; Membrane Potentials; Muscles; Phenytoin; Rana pipiens; Sodium; Tetrodotoxin; Veratridine; Veratrine | 1985 |
Phenytoin, tetrodotoxin, and acetylcholine release.
Topics: Acetylcholine; Animals; Brain; In Vitro Techniques; Phenytoin; Rats; Synaptosomes; Tetrodotoxin; Veratridine | 1986 |
Modulation by ouabain and diphenylhydantoin of veratridine-induced 22Na influx and its relation to 45Ca influx and the secretion of catecholamines in cultured bovine adrenal medullary cells.
Topics: Adrenal Medulla; Animals; Calcium; Catecholamines; Cattle; Cells, Cultured; Ouabain; Phenytoin; Sodium; Tetrodotoxin; Veratridine; Veratrine | 1985 |
On the mechanism by which phenytoin blocks post-tetanic potentiation at the frog neuromuscular junction.
Topics: Action Potentials; Animals; Electric Stimulation; Muscle Contraction; Neuromuscular Junction; Phenytoin; Rana ridibunda; Sodium; Tetrodotoxin | 1985 |
Pharmacology of aconitine-induced automaticity on in vitro cat myocardial preparations. II. Effects of refractory period prolongation, reduced sodium and tetrodotoxin.
Topics: Aconitum; Animals; Bretylium Compounds; Cats; Dose-Response Relationship, Drug; Electric Stimulation; Ethanolamines; Heart; Heart Rate; In Vitro Techniques; Lidocaine; Neural Conduction; Papillary Muscles; Perfusion; Permeability; Phenytoin; Practolol; Procainamide; Propranolol; Quinidine; Refractory Period, Electrophysiological; Sodium; Tetrodotoxin; Time Factors | 1974 |
Studies on the mechanism of action of diphenylhydantoin.
Topics: Adenosine Triphosphatases; Animals; Biological Transport; Crustacea; Cyanides; Hypoxia; Neurons; Ouabain; Peripheral Nerves; Phenobarbital; Phenytoin; Potassium; Schwann Cells; Sodium; Tetrodotoxin; Trimethadione | 1970 |
A highly ion-sensitive ATP-phosphorylation system in lobster nerve.
Topics: Acetylcholine; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Beryllium; Calcium; Cell Membrane; DDT; Dinitrophenols; Hemicholinium 3; Hydrogen-Ion Concentration; Imidazoles; Kinetics; Magnesium; Nephropidae; Ouabain; Peripheral Nerves; Phenytoin; Phosphorus Radioisotopes; Potassium; Procaine; Sodium; Sparteine; Tetrodotoxin | 1974 |
Diphenylhydantoin and calcium. Relation to norepinephrine release from brain slices.
Topics: Animals; Brain; Calcium; Calcium Isotopes; Cell Membrane Permeability; Magnesium; Norepinephrine; Ouabain; Phenytoin; Potassium; Procaine; Rats; Tetrodotoxin; Tritium | 1973 |
A-V conduction disturbance: its pathophysiology and pharmacology.
Topics: Animals; Anti-Arrhythmia Agents; Benzazepines; Cardiac Glycosides; Heart Conduction System; Imidazoles; Magnesium; Phenytoin; Potassium; Propranolol; Quinidine; Rabbits; Sodium; Tetrodotoxin | 1973 |
Mode of action of new anti-arrhythmic agents.
Topics: Acetylcholine; Aconitum; Action Potentials; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Calcium; Heart; In Vitro Techniques; Phenytoin; Propranolol; Rabbits; Stimulation, Chemical; Tetrodotoxin | 1968 |
[Cardiac action of crystalline tetrodotoxin. 3. Effects on the extension of non-reacting period of the isolated atria].
Topics: Animals; Arrhythmias, Cardiac; Electric Stimulation; Guinea Pigs; Heart; Heart Atria; In Vitro Techniques; Phenytoin; Procaine; Quinidine; Tetrodotoxin; Toxins, Biological | 1967 |
Drug-ionic channel interactions: single-channel measurements.
Topics: Animals; Anticonvulsants; Axons; Batrachotoxins; Calcium; Ion Channels; Membrane Potentials; Phenytoin; Pyrethrins; Receptors, Neurotransmitter; Sodium; Synaptic Transmission; Tetrodotoxin | 1984 |
A comparison of the effects of pentobarbital and diphenylhydantoin on the GABA sensitivity and excitability of adult sensory ganglion cells.
Topics: Animals; Dose-Response Relationship, Drug; Evoked Potentials; gamma-Aminobutyric Acid; Ganglia, Spinal; Ion Channels; Pentobarbital; Phenytoin; Rats; Receptors, Cell Surface; Receptors, GABA-A; Tetrodotoxin; Veratridine | 1981 |
Influences of tetrodotoxin, amiloride, phenytoin, aconitine, tetraethylammonium on ACTH-an isoproterenol-mediated lipolysis in isolated rat adipocytes.
Topics: Aconitine; Adipose Tissue; Adrenocorticotropic Hormone; Amiloride; Animals; Electrolytes; In Vitro Techniques; Isoproterenol; Lipolysis; Male; Phenytoin; Rats; Rats, Inbred Strains; Tetraethylammonium Compounds; Tetrodotoxin | 1982 |
Comparative actions of phenytoin and other anticonvulsant drugs on potassium- and veratridine-stimulated calcium uptake in synaptosomes.
Topics: Animals; Anticonvulsants; Brain; Calcium; Hydantoins; In Vitro Techniques; Manganese; Phenytoin; Potassium; Rats; Synaptosomes; Tetrodotoxin; Veratridine | 1982 |
Hippocampal slices: glutamate overflow and cellular damage from ischemia are reduced by sodium-channel blockade.
Topics: Animals; Brain Ischemia; Electrophysiology; Glutamic Acid; Hippocampus; In Vitro Techniques; Phenytoin; Rats; Rats, Inbred Strains; Sodium Channel Blockers; Tetrodotoxin; Time Factors | 1995 |
Differential up-regulation of voltage-dependent Na+ channels induced by phenytoin in brains of genetically seizure-susceptible (E1) and control (ddY) mice.
Topics: Amphibian Proteins; Animals; Carrier Proteins; Cerebral Cortex; Epilepsy; Mice; Mice, Neurologic Mutants; Nerve Tissue Proteins; Phenytoin; RNA, Messenger; Saxitoxin; Sodium Channels; Synaptosomes; Tetrodotoxin; Up-Regulation; Veratridine | 1994 |
Damage from oxygen and glucose deprivation in hippocampal slices is prevented by tetrodotoxin, lidocaine and phenytoin without blockade of action potentials.
Topics: Action Potentials; Animals; Brain Ischemia; Evoked Potentials; Hippocampus; Hypoxia, Brain; In Vitro Techniques; Lidocaine; Male; Phenytoin; Rats; Rats, Wistar; Synaptic Transmission; Tetrodotoxin | 1994 |
Phenytoin blocks N-methyl-D-aspartate responses of mouse central neurons.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Glycine; In Vitro Techniques; Magnesium; Membrane Potentials; Mice; N-Methylaspartate; Neurons; Phenytoin; Potassium; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Tetrodotoxin | 1993 |
Differential block of two types of sodium channels by anticonvulsants.
Topics: Action Potentials; Animals; Anticonvulsants; Carbamazepine; Ganglia, Spinal; Neurons; Phenytoin; Rats; Sodium Channels; Tetrodotoxin | 1996 |
Phenytoin and carbamazepine: differential inhibition of sodium currents in small cells from adult rat dorsal root ganglia.
Topics: Animals; Anticonvulsants; Carbamazepine; Cells, Cultured; Ganglia, Spinal; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Phenytoin; Rats; Rats, Wistar; Sodium Channel Blockers; Tetrodotoxin | 1997 |
Sodium channel modulators prevent oxygen and glucose deprivation injury and glutamate release in rat neocortical cultures.
Topics: Animals; Calcium; Cell Death; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Antagonists; Glucose; Glutamic Acid; L-Lactate Dehydrogenase; Lidocaine; Neurons; Phenytoin; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sodium Channel Blockers; Tetrodotoxin | 1997 |
Sodium channel blockade unmasks two temporally distinct mechanisms of striatal dopamine release during hypoxia/hypoglycaemia in vitro.
Topics: Animals; Dopamine; Electrophysiology; Extracellular Space; Hypoglycemia; Hypoxia, Brain; In Vitro Techniques; Lidocaine; Male; Neostriatum; Phenytoin; Rats; Rats, Wistar; Sodium Channel Blockers; Tetrodotoxin | 1997 |
Lamotrigine inhibits monoamine uptake in vitro and modulates 5-hydroxytryptamine uptake in rats.
Topics: Acetates; Amines; Animals; Anticonvulsants; Biogenic Amines; Blood Platelets; Brain; Carbamazepine; Cyclohexanecarboxylic Acids; Dopamine; Dopamine Uptake Inhibitors; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Lithium; Male; Norepinephrine; p-Chloroamphetamine; Phenytoin; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Agents; Serotonin Syndrome; Synaptosomes; Tetrodotoxin; Triazines; Valproic Acid; Zonisamide | 1998 |
Ionic mechanisms underlying repetitive high-frequency burst firing in supragranular cortical neurons.
Topics: Action Potentials; Aging; Animals; Calcium; Chelating Agents; Cycloleucine; Egtazic Acid; Female; Ferrets; In Vitro Techniques; Lidocaine; Male; Neurons; Phenytoin; Potassium; Potassium Channels; Pyramidal Cells; Sodium; Sodium Channels; Tetrodotoxin; Visual Cortex | 2000 |
Electrophysiological and pharmacological properties of the human brain type IIA Na+ channel expressed in a stable mammalian cell line.
Topics: Animals; Brain Chemistry; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Electric Conductivity; Electrophysiology; Gene Expression; Humans; Lamotrigine; Patch-Clamp Techniques; Phenytoin; Rats; Recombinant Proteins; Sodium Channels; Tetrodotoxin; Transfection; Triazines | 2001 |
Extracellular calcium modulates persistent sodium current-dependent burst-firing in hippocampal pyramidal neurons.
Topics: Action Potentials; Animals; Calcium; Cell Membrane; Chelating Agents; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activators; Extracellular Space; Gap Junctions; Hippocampus; In Vitro Techniques; Lysine; Nickel; Phenytoin; Phorbol Esters; Potassium Channel Blockers; Potassium Channels; Protein Kinase C; Pyramidal Cells; Rats; Sensory Thresholds; Sodium; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin | 2001 |
Na(+) channel effects of remacemide and desglycinyl-remacemide in rat cortical synaptosomes.
Topics: Acetamides; Animals; Anticonvulsants; Carbamazepine; Cerebral Cortex; Dose-Response Relationship, Drug; Lamotrigine; Male; Phenethylamines; Phenytoin; Rats; Rats, Wistar; Sodium; Sodium Channels; Synaptosomes; Tetrodotoxin; Triazines; Veratridine | 2002 |
Contribution of functional voltage-gated Na+ channel expression to cell behaviors involved in the metastatic cascade in rat prostate cancer: I. Lateral motility.
Topics: Aconitine; Animals; Carcinoma; Cell Division; Cell Movement; Cnidarian Venoms; Cytoskeletal Proteins; Cytoskeleton; Gene Expression Regulation, Neoplastic; Ion Transport; Male; Marine Toxins; Neoplasm Metastasis; Oxocins; Patch-Clamp Techniques; Phenytoin; Prostatic Neoplasms; Rats; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin; Tumor Cells, Cultured; Veratridine | 2003 |
Ionic currents underlying rhythmic bursting of ventral mossy cells in the developing mouse dentate gyrus.
Topics: 2-Amino-5-phosphonovalerate; Anesthetics, Local; Animals; Anticonvulsants; Bicuculline; Cadmium; Calbindin 2; Cesium; Dentate Gyrus; Drug Combinations; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Glutamate Decarboxylase; Immunohistochemistry; In Vitro Techniques; Ion Channels; Isoenzymes; Membrane Potentials; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Neurons; Nickel; Patch-Clamp Techniques; Phenytoin; Quinoxalines; S100 Calcium Binding Protein G; Tetrodotoxin | 2003 |
Subthreshold oscillations generated by TTX-sensitive sodium currents in dorsal cochlear nucleus pyramidal cells.
Topics: Acoustic Stimulation; Action Potentials; Animals; Animals, Newborn; Auditory Threshold; Biological Clocks; Cadmium; Cochlear Nucleus; In Vitro Techniques; Neural Inhibition; Neurons; Phenytoin; Rats; Sodium Channel Blockers; Sodium Channels; Synaptic Transmission; Tetrodotoxin | 2003 |
Sodium channels contribute to microglia/macrophage activation and function in EAE and MS.
Topics: Animals; Axons; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Gliosis; Macrophages; Male; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; NAV1.6 Voltage-Gated Sodium Channel; Nerve Degeneration; Nerve Tissue Proteins; Neuroprotective Agents; Phagocytosis; Phenytoin; RNA, Messenger; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin; Up-Regulation | 2005 |
Intrinsic bursting of immature CA3 pyramidal neurons and consequent giant depolarizing potentials are driven by a persistent Na+ current and terminated by a slow Ca2+ -activated K+ current.
Topics: Animals; Animals, Newborn; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Membrane Potentials; Metals, Heavy; Neurons; Patch-Clamp Techniques; Phenytoin; Potassium; Potassium Channels, Calcium-Activated; Rats; Rats, Wistar; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin | 2006 |
Resonance (approximately 10 Hz) of excitatory networks in motor cortex: effects of voltage-dependent ion channel blockers.
Topics: Anesthetics, Local; Animals; Calcium Channel Blockers; Electrophysiology; Ethosuximide; Evoked Potentials; Excitatory Amino Acid Antagonists; In Vitro Techniques; Ion Channels; Magnesium; Mibefradil; Mice; Motor Cortex; Neocortex; Phenytoin; Potassium Channel Blockers; Potassium Channels; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Riluzole; Sodium Channel Blockers; Tetrodotoxin | 2007 |
Sodium channel activity modulates multiple functions in microglia.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Brain; Cell Movement; Cell Proliferation; Cells, Cultured; Coculture Techniques; Cytokines; Gliosis; Inflammation Mediators; Microglia; NAV1.1 Voltage-Gated Sodium Channel; NAV1.5 Voltage-Gated Sodium Channel; NAV1.6 Voltage-Gated Sodium Channel; Nerve Tissue Proteins; Phagocytosis; Phenytoin; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin | 2009 |
Effects of antiepileptic drugs on GABA release from rat and human neocortical synaptosomes.
Topics: Adolescent; Adult; Aged; Amines; Animals; Anticonvulsants; Calcium; Carbamazepine; Child; Child, Preschool; Cyclohexanecarboxylic Acids; Female; GABA Antagonists; Gabapentin; gamma-Aminobutyric Acid; Humans; Infant; Lamotrigine; Levetiracetam; Male; Middle Aged; Neocortex; Nipecotic Acids; Oximes; Phenytoin; Piracetam; Potassium; Pregabalin; Rats; Rats, Wistar; Synaptosomes; Tetanus Toxin; Tetrodotoxin; Triazines; Valproic Acid; Veratridine; Young Adult | 2011 |
Vinpocetine inhibits glutamate release induced by the convulsive agent 4-aminopyridine more potently than several antiepileptic drugs.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Calcium; Carbamazepine; Drug Interactions; Epilepsy; Fructose; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; In Vitro Techniques; Lamotrigine; Male; Nerve Endings; Oxcarbazepine; Phenytoin; Potassium Channel Blockers; Rats; Rats, Wistar; Sodium; Sodium Channel Blockers; Tetrodotoxin; Topiramate; Triazines; Tritium; Vinca Alkaloids | 2011 |
Blockade of voltage-gated sodium channels inhibits invasion of endocrine-resistant breast cancer cells.
Topics: Breast Neoplasms; Cell Movement; Cell Proliferation; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; NAV1.5 Voltage-Gated Sodium Channel; Neoplasm Invasiveness; Patch-Clamp Techniques; Phenytoin; Tetrodotoxin | 2016 |
The SCN8A encephalopathy mutation p.Ile1327Val displays elevated sensitivity to the anticonvulsant phenytoin.
Topics: Anticonvulsants; Cell Line, Transformed; Electric Stimulation; Female; Green Fluorescent Proteins; Humans; Isoleucine; Male; Membrane Potentials; Models, Molecular; Mutation; NAV1.6 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Phenytoin; Sodium Channel Blockers; Tetrodotoxin; Transfection; Valine | 2016 |
The antiepileptic medications carbamazepine and phenytoin inhibit native sodium currents in murine osteoblasts.
Topics: Animals; Animals, Newborn; Anticonvulsants; Carbamazepine; Cells, Cultured; Dose-Response Relationship, Drug; Electric Stimulation; Gene Expression Regulation; Membrane Potentials; Mice; Mice, Inbred C57BL; Osteoblasts; Patch-Clamp Techniques; Phenytoin; RNA, Messenger; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin | 2016 |
Regulation of P2X7 receptor function of neural progenitor cells in the hippocampal subgranular zone by neuronal activity in the dentate gyrus.
Topics: 4-Aminopyridine; Action Potentials; Adenosine Triphosphate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Dentate Gyrus; Female; Gabapentin; Male; Mice; Muscimol; N-Methylaspartate; Neural Stem Cells; Neurons; Phenytoin; Receptors, Purinergic P2X7; Tetrodotoxin; Valproic Acid | 2018 |