phenytoin has been researched along with tamoxifen in 25 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.00) | 18.7374 |
| 1990's | 2 (8.00) | 18.2507 |
| 2000's | 8 (32.00) | 29.6817 |
| 2010's | 14 (56.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Andrews, PR; Craik, DJ; Martin, JL | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Buttar, D; Colclough, N; Gerhardt, S; MacFaul, PA; Maskos, K; Phillips, SD; Plowright, A; Steinbacher, S; Steuber, H; Tam, K; Whittamore, P | 1 |
| Sen, S; Sinha, N | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Honda, K; Izumi, T; Miyaji, Y; Nakayama, S; Okazaki, O; Okudaira, N; Shiosakai, K; Sugiyama, D; Suzuki, W; Takakusa, H; Watanabe, A | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Bloomer, WD; Papadopoulou, MV; Rosenzweig, HS | 1 |
| Couldwell, WT; Dyck, P; Hinton, DR; Rabinowicz, AL | 1 |
| Bowen, WD; Daunes, S; Faye, JC; Kedjouar, B; Klaebe, A; Poirot, M; Vilner, BJ | 1 |
| Soory, M; Tilakaratne, A | 1 |
| Fleisher, D; Flynn, G; Forsberg, M; Heimbach, T; Leppänen, J; Li, LY; Matsunaga, Y; Oh, DM; Savolainen, J | 1 |
| Fleisher, D; Garcia, G; Heimbach, T; Li, LY; Oh, DM; Rodríguez-Hornedo, N | 1 |
| Chen, J; Hage, DS; Ohnmacht, CM | 1 |
| Asimiadou, S; Bittigau, P; Dzietko, M; Felderhoff-Mueser, U; Ikonomidou, C; Kaindl, AM; Manthey, D; Mozrzymas, JW; Pesditschek, S; Pytel, M; Sifringer, M; Studniarczyk, D | 1 |
| Gryn, SE; Kim, RB; Teft, WA | 1 |
| Cardozo, T; Fadiel, A; Hamza, A; Naftolin, F; Song, J; Tivon, D | 1 |
1 review(s) available for phenytoin and tamoxifen
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
24 other study(ies) available for phenytoin and tamoxifen
| Article | Year |
|---|---|
Functional group contributions to drug-receptor interactions.
Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship | 1984 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions.
Topics: Binding Sites; Crystallography, X-Ray; Drug Interactions; Humans; Pharmaceutical Preparations; Protein Binding; Protein Structure, Tertiary; Serum Albumin; Spectrometry, Fluorescence | 2010 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites.
Topics: Glutathione; Pharmacology; Sulfur Radioisotopes | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
The antitubercular activity of various nitro(triazole/imidazole)-based compounds.
Topics: Animals; Antitubercular Agents; Cell Line; Chlorocebus aethiops; Dose-Response Relationship, Drug; Humans; Imidazoles; Macrophages; Mice; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Nitro Compounds; Structure-Activity Relationship; Triazoles | 2017 |
High-dose tamoxifen in treatment of brain tumors: interaction with antiepileptic drugs.
Topics: Adult; Brain Neoplasms; Cell Division; Drug Interactions; Glioma; Humans; Magnetic Resonance Imaging; Male; Phenytoin; Protein Kinase C; Signal Transduction; Tamoxifen | 1995 |
Structural similitudes between cytotoxic antiestrogen-binding site (AEBS) ligands and cytotoxic sigma receptor ligands. Evidence for a relationship between cytotoxicity and affinity for AEBS or sigma-2 receptor but not for sigma-1 receptor.
Topics: Allosteric Regulation; Animals; Antineoplastic Agents, Hormonal; Benzhydryl Compounds; Binding Sites; Cell Division; Cell Line; Humans; Ligands; Male; Phenytoin; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, sigma; Sigma-1 Receptor; Structure-Activity Relationship; Tamoxifen; Tumor Cells, Cultured | 1999 |
Modulation of androgen metabolism by phenytoin, oestradiol and tamoxifen in human gingival fibroblasts.
Topics: Adult; Androstenedione; Anticonvulsants; Cells, Cultured; Dihydrotestosterone; Estradiol; Estrogen Antagonists; Female; Fibroblasts; Gingiva; Gingival Overgrowth; Humans; Male; Middle Aged; Phenytoin; Tamoxifen; Testosterone | 2003 |
Absorption rate limit considerations for oral phosphate prodrugs.
Topics: Administration, Oral; Algorithms; Animals; Area Under Curve; Biological Transport, Active; Caco-2 Cells; Catechols; Chemical Phenomena; Chemistry, Physical; Humans; Hydrocortisone; Hydrogen-Ion Concentration; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Jejunum; Male; Nitriles; Perfusion; Permeability; Phenytoin; Prodrugs; Rats; Rats, Wistar; Tamoxifen | 2003 |
Enzyme-mediated precipitation of parent drugs from their phosphate prodrugs.
Topics: Alkaline Phosphatase; Caco-2 Cells; Chemical Precipitation; Chromatography, High Pressure Liquid; Crystallization; Drug Stability; Estramustine; Humans; Mass Spectrometry; Organophosphates; Phenytoin; Prodrugs; Solubility; Tamoxifen | 2003 |
Characterization of drug interactions with soluble beta-cyclodextrin by high-performance affinity chromatography.
Topics: beta-Cyclodextrins; Chromatography, Affinity; Chromatography, High Pressure Liquid; Phenytoin; Tamoxifen | 2004 |
Protection with estradiol in developmental models of apoptotic neurodegeneration.
Topics: Animals; Animals, Newborn; Apoptosis; Bicuculline; Blotting, Western; Brain; Caenorhabditis elegans Proteins; Cell Count; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Estradiol; Estrogen Antagonists; Extracellular Signal-Regulated MAP Kinases; GABA Antagonists; Hypoxia; Immunohistochemistry; In Situ Nick-End Labeling; Membrane Potentials; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Phenobarbital; Phenytoin; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Receptors, GABA-A; Silver Staining; Tamoxifen | 2005 |
Profound reduction in the tamoxifen active metabolite endoxifen in a patient on phenytoin for epilepsy compared with a CYP2D6 genotype matched cohort.
Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms; Cohort Studies; Cytochrome P-450 CYP2D6; Drug Interactions; Epilepsy; Female; Genotype; Humans; Male; Middle Aged; Pharmacogenetics; Phenytoin; Precision Medicine; Tamoxifen | 2014 |
Phenytoin is an estrogen receptor α-selective modulator that interacts with helix 12.
Topics: Amino Acid Sequence; Anticonvulsants; Binding Sites; Binding, Competitive; Crystallography; Dose-Response Relationship, Drug; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Estrone; Gene Expression Regulation; Genes, Reporter; Humans; MCF-7 Cells; Molecular Docking Simulation; Molecular Sequence Data; Phenytoin; Protein Binding; Protein Structure, Secondary; Selective Estrogen Receptor Modulators; Tamoxifen; Transcription, Genetic; Transfection | 2015 |