phenytoin and sirolimus

phenytoin has been researched along with sirolimus in 11 studies

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (36.36)29.6817
2010's3 (27.27)24.3611
2020's4 (36.36)2.80

Authors

AuthorsStudies
Andricopulo, AD; Moda, TL; Montanari, CA1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Beattie, TJ; Hodges, CB; Jindal, RM; Maxwell, H; Murphy, AV1
Berarducci, M; Cutts, J; Dempsey, PK; Kadish, SP; Lee, G; Thomas, C1
Fridell, JA; Fung, JJ; Jain, AK; Patel, K; Rao, KN; Venkataramanan, R; Virji, M1
Chi, X; Huang, C; Li, J; Li, R; Wang, W; Wu, M; Zhou, D1
Del Priore, G; Hoffman, S; Noel, MS; Stega, D; Stega, J; Vandell, AG1
Del Priore, G; Gartrell, BA; Retter, A; Roach, M; Scher, HI; Sokol, GH1
Chung, V; Hartley, ML; Kim, DW; Kim, S; Noel, MS; Ocean, AJ; Philip, PA; Picozzi, VJ; Staszewski, H; Van Tornout, JM; Wang-Gillam, A; Wong, S1
Bernard, SA; Boilson, BA; Lemke, AI; Razonable, RR1

Reviews

1 review(s) available for phenytoin and sirolimus

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

3 trial(s) available for phenytoin and sirolimus

ArticleYear
A first-in-human study of the novel metabolism-based anti-cancer agent SM-88 in subjects with advanced metastatic cancer.
    Investigational new drugs, 2020, Volume: 38, Issue:2

    Topics: Aged; alpha-Methyltyrosine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Exanthema; Female; Humans; Hyperpigmentation; Male; Melanins; Middle Aged; Neoplasms; Phenytoin; Pilot Projects; Quality of Life; Sirolimus; Survival Analysis

2020
Phase II trial of SM-88, a cancer metabolism based therapy, in non-metastatic biochemical recurrent prostate cancer.
    Investigational new drugs, 2021, Volume: 39, Issue:2

    Topics: Aged; Aged, 80 and over; Androgen Antagonists; Humans; Kaplan-Meier Estimate; Male; Methoxsalen; Middle Aged; Neoplasm Recurrence, Local; Phenytoin; Prostate-Specific Antigen; Prostatic Neoplasms; Quality of Life; Sirolimus; Tyrosine

2021
A randomized phase II study of SM-88 plus methoxsalen, phenytoin, and sirolimus in patients with metastatic pancreatic cancer treated in the second line and beyond.
    Cancer medicine, 2022, Volume: 11, Issue:22

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Humans; Methoxsalen; Pancreatic Neoplasms; Phenytoin; Quality of Life; Sirolimus

2022

Other Studies

7 other study(ies) available for phenytoin and sirolimus

ArticleYear
Hologram QSAR model for the prediction of human oral bioavailability.
    Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24

    Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2007
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Use of rapamycin in a transplant patient who developed cyclosporin neurotoxicity.
    Pediatric nephrology (Berlin, Germany), 2001, Volume: 16, Issue:10

    Topics: Anticonvulsants; Child; Cyclosporine; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Graft Rejection; Humans; Immunosuppressive Agents; Kidney Failure, Chronic; Phenytoin; Seizures; Sirolimus

2001
Goosebumps.
    Lancet (London, England), 2002, Aug-31, Volume: 360, Issue:9334

    Topics: Astrocytoma; Brain Neoplasms; Carmustine; Dexamethasone; Diagnosis, Differential; Frontal Lobe; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Phenytoin; Piloerection; Seizures; Sirolimus; Taste Disorders; Temporal Lobe

2002
Phenytoin decreases the blood concentrations of sirolimus in a liver transplant recipient: a case report.
    Therapeutic drug monitoring, 2003, Volume: 25, Issue:1

    Topics: Area Under Curve; Drug Interactions; Female; Graft Rejection; Humans; Liver Transplantation; Middle Aged; Phenytoin; Sirolimus

2003
Inhibition of mTOR Pathway by Rapamycin Decreases P-glycoprotein Expression and Spontaneous Seizures in Pharmacoresistant Epilepsy.
    Journal of molecular neuroscience : MN, 2017, Volume: 61, Issue:4

    Topics: Adult; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Case-Control Studies; Drug Resistant Epilepsy; Female; Humans; Lactones; Male; Phenytoin; Rats; Rats, Sprague-Dawley; Seizures; Sirolimus; TOR Serine-Threonine Kinases

2017
Phenytoin to expedite sirolimus and tacrolimus elimination.
    Clinical transplantation, 2022, Volume: 36, Issue:12

    Topics: Humans; Immunosuppressive Agents; Kidney Transplantation; Phenytoin; Sirolimus; Tacrolimus

2022