phenytoin and sertraline

phenytoin has been researched along with sertraline in 15 studies

Research

Studies (15)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (13.33)	18.2507
2000's	3 (20.00)	29.6817
2010's	10 (66.67)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Gozalbes, R; Pineda-Lucena, A	1
Ekins, S; Williams, AJ; Xu, JJ	1
Alelyunas, YW; Bui, K; Empfield, JR; McCarthy, D; Pelosi-Kilby, L; Shen, C; Spreen, RC	1
Chang, G; Di, L; Huang, Y; Lin, Z; Liston, TE; Scott, DO; Troutman, MD; Umland, JP	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Cross, M; Muirhead, DC; Rapeport, WG; Wesnes, K; Williams, SA	1
Freedman, LS; Haselberger, MB; Tolbert, S	1
Birnbaum, AK; Nelson, MH; Remmel, RP	1
Eliasson, E; Pihlsgård, M	1

Reviews

1 review(s) available for phenytoin and sertraline

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

1 trial(s) available for phenytoin and sertraline

Article	Year
Absence of effect of sertraline on the pharmacokinetics and pharmacodynamics of phenytoin. The Journal of clinical psychiatry, 1996, Volume: 57 Suppl 1 Topics: 1-Naphthylamine; Administration, Oral; Adolescent; Adult; Cognition; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Humans; Male; Middle Aged; Phenytoin; Placebos; Psychological Tests; Psychomotor Performance; Reaction Time; Selective Serotonin Reuptake Inhibitors; Sertraline	1996

Article

Year

Absence of effect of sertraline on the pharmacokinetics and pharmacodynamics of phenytoin.

The Journal of clinical psychiatry, 1996, Volume: 57 Suppl 1

Topics: 1-Naphthylamine; Administration, Oral; Adolescent; Adult; Cognition; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Humans; Male; Middle Aged; Phenytoin; Placebos; Psychological Tests; Psychomotor Performance; Reaction Time; Selective Serotonin Reuptake Inhibitors; Sertraline

1996

Other Studies

13 other study(ies) available for phenytoin and sertraline

Article	Year
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
QSAR-based solubility model for drug-like compounds. Bioorganic & medicinal chemistry, 2010, Oct-01, Volume: 18, Issue:19 Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate. Bioorganic & medicinal chemistry letters, 2010, Dec-15, Volume: 20, Issue:24 Topics: Central Nervous System Agents; Drug Evaluation, Preclinical; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Solubility	2010
Species independence in brain tissue binding using brain homogenates. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:7 Topics: Animals; Brain; Dogs; Guinea Pigs; Humans; Macaca fascicularis; Mice; Rats; Species Specificity	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment. Journal of applied toxicology : JAT, 2012, Volume: 32, Issue:10 Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Elevated serum phenytoin concentrations associated with coadministration of sertraline. Journal of clinical psychopharmacology, 1997, Volume: 17, Issue:2 Topics: Aged; Aged, 80 and over; Anticonvulsants; Antidepressive Agents; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Male; Phenytoin; Sertraline	1997
Inhibition of phenytoin hydroxylation in human liver microsomes by several selective serotonin re-uptake inhibitors. Epilepsy research, 2001, Volume: 44, Issue:1 Topics: Aged; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Child, Preschool; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Fluoxetine; Humans; Hydroxylation; Male; Microsomes, Liver; Middle Aged; Paroxetine; Phenytoin; Selective Serotonin Reuptake Inhibitors; Sertraline; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases	2001
Significant reduction of sertraline plasma levels by carbamazepine and phenytoin. European journal of clinical pharmacology, 2002, Volume: 57, Issue:12 Topics: Anticonvulsants; Carbamazepine; Drug Interactions; Humans; Phenytoin; Selective Serotonin Reuptake Inhibitors; Sertraline	2002