phenytoin has been researched along with pentylenetetrazole in 177 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 110 (62.15) | 18.7374 |
| 1990's | 18 (10.17) | 18.2507 |
| 2000's | 15 (8.47) | 29.6817 |
| 2010's | 28 (15.82) | 24.3611 |
| 2020's | 6 (3.39) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Alkskas, IA; Azam, F; Khokra, SL; Prakash, O | 1 |
| Costa, E; Guidotti, A; Mao, CC; Suria, A | 1 |
| Ferrendelli, JA; Kinscherf, DA | 1 |
| Jones, DJ; Medina, MA; Palmer, GC; Stavinoha, WB | 1 |
| Costa, E; Guidotti, A; Mao, CC | 1 |
| Browning, RA; Hoffmann, WE; Simonton, RL | 1 |
| Fukumori, R; Kitagawa, H; Minegishi, A; Nakagawa, I; Satoh, T; Yanaura, S | 1 |
| Kang, HS; Oh, YK | 1 |
| Pálosi, E; Szeberényi, S; Szporny, L | 1 |
| Dóda, M; György, L; Koltai, MZ | 1 |
| Faugier-Grimaud, S | 1 |
| Brockman, WH; Strain, GM; Van Meter, WG | 1 |
| Hoover, JL; Kwon, YG; Marshall, GL; Nelson, WL; Pfeffer, GT | 1 |
| Bigler, ED; Fleming, DE; Shearer, DE | 1 |
| Gardner, CR; Webster, RA | 2 |
| Ayala, GF; Johnston, D | 1 |
| Cole, FR; Nelson, RB | 1 |
| Murasaki, M | 1 |
| O'Dea, MH; Reinhard, JF; Samour, CM; Vida, JA | 1 |
| Dwivedi, C; Harbison, RD | 1 |
| Desmedt, LK; Janssen, PA; Niemegeers, CJ | 1 |
| Barry, H; Sofia, RD; Solomon, TA | 1 |
| Kubová, H; Mares, P; Stanková, L | 1 |
| Kuang, P; Lang, S; Liu, J; Wu, W; Zhang, F | 1 |
| Fredow, G; Löscher, W | 1 |
| File, SE; Wilks, LJ | 1 |
| Furuichi, H; Imai, S; Kishii, K; Onozuka, M; Sugaya, A; Sugaya, E | 1 |
| Bodor, NS; Murakami, T; Nath, C; Pop, E; Shek, E | 1 |
| Kishii, K; Onozuka, M; Sugaya, E | 1 |
| Lloyd, KG | 1 |
| Creveling, CR; Daly, JW; Hollingsworth, EB; Lewandowski, G; Waters, JA | 1 |
| Hirayama, H; Horibe, M; Kurimoto, T; Machida, N; Shikuma, H; Shoji, S; Wada, S | 1 |
| Abed, WT | 1 |
| Kantarev, N; Parisheva, Z; Toreva, D | 1 |
| Anderson, RE; Ots, ME; Sundt, TM; Yaksh, TL | 1 |
| Rock, DM; Taylor, CP | 1 |
| Clark, CR; Lin, CM; Sansom, RT | 1 |
| Kaneda, H; Kaneto, H; Kawatani, S | 1 |
| Piredda, SG; Swinyard, EA; Woodhead, JH | 1 |
| Alexander, GJ; Alexander, RB; Chatterjie, N; Kopeloff, LM | 1 |
| File, SE; Pellow, S; Wilks, L | 1 |
| Gerald, MC; Massey, J; Spadaro, DC | 1 |
| De la Mora, MP; Tapia, R | 1 |
| Forrest, TP; Gilroy, ML; Vohra, MM; Yung, DK | 1 |
| Gogerty, JH; Iorio, LC; Ryan, EA | 1 |
| Vernadakis, A; Woodbury, DM | 1 |
| Millichap, JG | 1 |
| Arushanian, EB; Shapovalov, AI | 1 |
| Baxter, BL | 1 |
| Laycock, GM; Shulman, A | 1 |
| Rümke, CL | 1 |
| Buchanan, AS; Laycock, GM; Shulman, A | 1 |
| Bapat, SK; Dhawan, BN; Saxena, VC | 1 |
| Izquierdo, I | 1 |
| Kirsten, EB; Schoener, EP | 1 |
| Kazama, K | 1 |
| Niner, JM; Pace, DG; Raines, A | 1 |
| Carrano, RA; McCurdy, DH; Neumeyer, JL; Weinhardt, KK | 1 |
| Baxter, MG; Miller, AA; Webster, RA | 1 |
| Babington, RG; Horovitz, ZP | 1 |
| Frey, HH; Meyer, H | 1 |
| Pérez de la Mora, M; Tapia, R | 1 |
| Berry, CA; Faingold, CL | 1 |
| Costa, E; Doteuchi, M | 1 |
| Izquierdo, I; Tannhauser, M | 1 |
| Kornet, MJ; Lubawy, WC; Thorstenson, JH | 1 |
| Chesher, GB; Jackson, DM | 1 |
| Cely, W; Karler, R; Olsen, DM; Turkanis, SA | 1 |
| Swinyard, EA | 1 |
| Halpern, LM; Ward, AA | 1 |
| Christensen, JA; Lassen, JB; Lund, J; Squires, RF | 1 |
| Ahmad, A; Dhawan, BN | 1 |
| Asahi, K; Iizuka, H; Okabe, Y; Yanagida, T | 1 |
| Fukuda, T; Katsuda, N; Tanaka, K | 1 |
| Blackburn, WH; Napoli, MD; Wallin, RF | 1 |
| Clark, LD; Weinreich, D | 1 |
| Coeugniet, E; Dobrescu, D | 1 |
| Levitt, B; Raines, A; Sohn, YJ | 1 |
| Combs, G; Diamond, L; Glasser, AC | 1 |
| Southgate, PJ | 1 |
| Krimsley, V; Shaffer, JW; Steinberg, E; Winstead, WB | 1 |
| Burba, JV | 1 |
| Keyl, AC; Nishie, K; Waiss, AC | 1 |
| Kretzschmar, R; Meyer, HJ | 1 |
| Bartels, E; Rosenberg, P | 1 |
| Natoff, IL; Reiff, B | 1 |
| Sanders, HD | 1 |
| Barondes, SH; Cohen, HD | 1 |
| Calder, LD; Karler, R; Turkanis, SA | 1 |
| Kosoĭ, MIu | 1 |
| Czuczwar, SJ; Kleinrok, Z; Turski, L | 2 |
| Horiuchi, M; Ibii, N; Yamamoto, K | 1 |
| Karler, R; Turkanis, SA | 1 |
| Lajtha, A; Toth, E | 1 |
| Chou, RC; Levy, G | 1 |
| Baimbridge, KG; Miller, JJ | 1 |
| Syapin, PJ | 1 |
| Bleck, V; Lewin, E | 1 |
| Hlavatá, J; Lisková, K; Mares, P; Mudrochová, M | 1 |
| Alexander, GJ; Chatterjie, N; Kopeloff, LM | 2 |
| Avendaño, MC; Ballesteros, P; Cañadas, S; González, MP | 1 |
| Kiełek, MB; Szadowska, A | 1 |
| Freeman, JJ; Kosh, JW; Powers, DL; Sowell, JW | 1 |
| Bailleux, V; Hamoir, G; Nuyts, JP; Poupaert, JH; Stables, JP; Vallée, L; Vamecq, J | 1 |
| Lambert, DM; Poupaert, JH; Scriba, GK | 1 |
| Bastidas Ramírez, BE; García Estrada, J; García López, P; Garzón, P; Navarro Ruíz, A | 1 |
| Karolak-Wojciechowska, J; Kiec-Kononowicz, K; Kwiatkowski, W | 1 |
| Husain, S; Kumar, N; Mehndiratta, MM; Rohatgi, A | 1 |
| Mares, P; Nováková, J; Seidl, J | 1 |
| Pleuvry, BJ; Rodger, C | 1 |
| Kozicka, M | 1 |
| Scriba, GK | 1 |
| Bourhim, M; Diouf, O; Lambert, DM; Poupaert, JH; Stables, JP; Vamecq, J | 1 |
| Chang, CC; Chiou, LC; Ling, JY | 1 |
| Horga, JF; Javaloy, J; Román, JF; Vidal, MT; Zapater, P | 1 |
| David, J; Joseph, S; Joseph, T | 1 |
| Bot, AP; Corner, MA | 1 |
| Casillass-Ochoa, J; García-Estrada, J; García-López, PM; Garzón-De la Mora, P; Navarro-Ruíz, A; Villanueva-Michel, T; Villarreal-de Puga, LM | 1 |
| Bac, P; Delcourt, P; Herrenknecht, C; Maurois, P; Stables, JP; Vamecq, J | 1 |
| Kohn, H; LeTiran, A; Stables, JP | 1 |
| Bough, KJ; Eagles, DA | 1 |
| Kamalinejad, M; Sayyah, M; Valizadeh, J | 1 |
| Akamatsu, N; Tsuji, S | 1 |
| FROMMEL, E; GOLD, P; RADOUCO, C | 1 |
| SIGG, EB; WARNER, CL; YEN, HC | 1 |
| BOTTIROLI, JA; ROSENBERG, FJ | 1 |
| CASTILLO, LS; TIMIRAS, PS | 2 |
| CHAREST, MP; DAVIS, MA; GAUDRY, R; HERR, F; THOMAS, RA; WINTHROP, SO | 1 |
| BHARGAVA, KP; BHATTACHARYA, SS; KISHOR, K; SAXENA, PN | 1 |
| FREY, HH | 1 |
| Gupta, RK; Tandon, VR | 1 |
| Anderson, NJ; Slough, S; Watson, WP | 1 |
| Chouinard, SW; Littleton, JT; Saraswati, S; Stilwell, GE | 1 |
| He, J; Ma, SL | 1 |
| Alves, PB; Antoniolli, AR; Blank, AF; Bonjardim, LR; Leite, BS; Lessa, NM; Quintans-Júnior, LJ; Santos, MR; Souza, TT | 1 |
| Geciken, AE; Gökçe, M; Tosuni, AU; Yildirim, E | 1 |
| Nwafor, PA; Okokon, JE | 1 |
| Akula, KK; Dhir, A; Kulkarni, SK | 1 |
| Ahmad, M; Raza, ML; Shaheen, F; Simjee, SU; Zeeshan, M | 1 |
| Abd El-Latif, HA; Abu Yossef, HA; Hassan, GS; Ragab, FA; Yahya, TA | 1 |
| Badami, S; Mahendran, S; Thippeswamy, BS; Veerapur, VP | 1 |
| Anitha, T; Gajera, K; Jayaraman, R; Joshi, VD; Ladani, K; Manisenthil, KT; Palei, NN | 1 |
| Kamiński, K; Obniska, J; Rzepka, S | 1 |
| Amini, M; Davood, A; Iman, M; Nematollahi, A; Shafaroodi, H; Shirazi, M | 1 |
| Acar, MD; Bagirici, F; Marangoz, C; Sefil, F | 1 |
| Jin, S; Li, J; Liu, L; Liu, XD; Yao, D | 1 |
| Aoyama, K; Kikuchi-Utsumi, K; Matsumura, N; Nakaki, T; Sakamaki, K; Watabe, M | 1 |
| Botros, S; El-Dash, Y; Khalil, NA; Naguib, BH | 1 |
| Bogo, MR; Bonan, CD; Nery, LR; Piato, AL; Schaefer, IC; Siebel, AM | 1 |
| Abdar, M; Mandegary, A; Sharififar, F | 1 |
| Bruno-Blanch, LE; Higgs, J; Mangialavori, IC; Marder, M; Pastore, V; Wasowski, C | 1 |
| Ohtsuki, S; Terasaki, T; Uchida, Y | 1 |
| Burrell, B; Hahn, E | 1 |
| Ali, R; Siddiqui, N | 1 |
| Babapour, V; Gavzan, H; Sardari, S; Sayyah, M | 1 |
| Goel, RK; Singh, D; Singh, P | 1 |
| Chen, SL; Fan, Q; Ma, H; Zhang, C | 1 |
| Díaz, FV; Rasgado, LA; Reyes, GC | 1 |
| Bednarski, M; Byrtus, H; Czopek, A; Kazek, G; Pawłowski, M; Sapa, J; Siwek, A; Zagórska, A | 1 |
| da Conceição Machado, K; de Carvalho Melo Cavalcante, AA; Gomes Júnior, AL; Momchilova, A; Tchekalarova, J; Tzoneva, R | 1 |
| Abasi-Moghadam, M; Ghasemi-Dehno, A; Palizvan, MR; Sadegh, M | 1 |
| Al-Khalek, HAA; Khalifa, AE; Masoud, SI; Nagib, MM; Rahmo, RM; Sabri, NA; Tadros, MG | 1 |
| Barbas, LAL; de Mello, VJ; do Nascimento, JLM; Dos Santos Batista, L; Dos Santos Batista, P; Farias, RAF; Gomes-Leal, W; Hamoy, M; Hutchison, WD; Marcondes, HC; Taylor, JG; Torres, MF | 1 |
| Akula, A; Danduga, RCSR; Ineedi, S; Kola, PK; Mohammad, A; Nissankara Rao, LS | 1 |
| Jand, A; Mousavi-Hasanzadeh, M; Palizvan, MR; Rezaeian-Varmaziar, H; Shafaat, O | 1 |
| Abasi-Moghadam, M; Ghasemi-Dehno, A; Jand, A; Mousavi-Hasanzadeh, M; Palizvan, MR; Sadegh, M | 1 |
| Goel, RK; Kaur, S; Sharma, NK | 1 |
| Agarwal, A; Arora, R; Ganeshan N, S; Gupta, YK; Kaleekal, T; Kumar, R; Sarangi, SC | 1 |
| Amalakanti, S; Bhat, UA; Chakravarty, S; Khandelwal, N; Kumar, A; Mylavarapu, MB; Sundarachary, NV | 1 |
| Behbahaninia, K; Davood, A; Jahromy, MH; Taghizad, S | 1 |
| Araújo, DB; Azevedo, JEC; Barbas, LAL; da Silva, ALM; Hamoy, AO; Hamoy, M; Lopes, DCF; Lopez, MEC; Mello, VJ; Nascimento, CP; Pereira, RG; Rodrigues, SF; Vieira, LR | 1 |
| Abula, T; Alberts, PSF; Lee, HJ; Raimondo, JV; Salile, SS; Stafford, GI | 1 |
6 review(s) available for phenytoin and pentylenetetrazole
| Article | Year |
|---|---|
New concepts on the mechanism of action of benzodiazepines.
Topics: Animals; Benzodiazepines; Cerebellum; Chlordiazepoxide; Cyclic AMP; Diazepam; gamma-Aminobutyric Acid; Ganglia, Autonomic; Glycine; Humans; Isoniazid; Medulla Oblongata; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Receptors, Drug; Seizures; Sensory Receptor Cells; Spinal Cord; Strychnine; Substantia Nigra | 1975 |
[GABAergic theory of epilepsy].
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Benzodiazepines; Bicuculline; Brain; Dogs; Epilepsy; gamma-Aminobutyric Acid; Humans; Mice; Nerve Endings; Pentylenetetrazole; Phenobarbital; Phenytoin; Rats; Receptors, GABA-A; Synapses; Valproic Acid | 1986 |
Relation of laboratory evaluation to clinical effectiveness of antiepileptic drugs.
Topics: Acetazolamide; Adrenocorticotropic Hormone; Animals; Anticonvulsants; Benzazepines; Clinical Trials as Topic; Drug Tolerance; Electroencephalography; Electroshock; Epilepsy; Ethosuximide; Humans; Pentylenetetrazole; Phenobarbital; Phenytoin; Primidone; Seizures; Trimethadione; Urea | 1969 |
Laboratory evaluation of antiepileptic drugs. Review of laboratory methods.
Topics: Animals; Anticonvulsants; Biological Assay; Brain Injuries; Diagnosis; Electroconvulsive Therapy; Electroshock; Humans; Methionine Sulfoximine; Methods; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Seizures; Strychnine; Thiosemicarbazones; Trimethadione; Urea | 1969 |
Changes in CNS sensitivity to cannabinoids with repeated treatment: tolerance and auxoesthesia.
Topics: Animals; Brain; Cannabidiol; Cannabinoids; Dronabinol; Drug Tolerance; Electroshock; Kindling, Neurologic; Mice; Pentylenetetrazole; Phenytoin; Picrotoxin; Seizures | 1984 |
[Treatment of status epilepticus].
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Electric Stimulation Therapy; Humans; Magnetics; Midazolam; Pentobarbital; Pentylenetetrazole; Phenytoin; Rats; Status Epilepticus | 2001 |
1 trial(s) available for phenytoin and pentylenetetrazole
| Article | Year |
|---|---|
Relation of laboratory evaluation to clinical effectiveness of antiepileptic drugs.
Topics: Acetazolamide; Adrenocorticotropic Hormone; Animals; Anticonvulsants; Benzazepines; Clinical Trials as Topic; Drug Tolerance; Electroencephalography; Electroshock; Epilepsy; Ethosuximide; Humans; Pentylenetetrazole; Phenobarbital; Phenytoin; Primidone; Seizures; Trimethadione; Urea | 1969 |
171 other study(ies) available for phenytoin and pentylenetetrazole
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Synthesis of some novel N4-(naphtha[1,2-d]thiazol-2-yl)semicarbazides as potential anticonvulsants.
Topics: Animals; Anticonvulsants; Brain Chemistry; Glutathione Peroxidase; Malondialdehyde; Mice; Motor Activity; Rats; Seizures; Semicarbazides; Structure-Activity Relationship; Superoxide Dismutase | 2009 |
Cyclic nucleotides in epileptic brain: effects of pentylenetetrazol on regional cyclic AMP and cyclic GMP levels in vivo.
Topics: Animals; Brain; Cerebellum; Cerebral Cortex; Corpus Striatum; Cyclic AMP; Cyclic GMP; Ethosuximide; Female; Hippocampus; Mice; Pentylenetetrazole; Phenobarbital; Phenytoin; Seizures; Thalamus | 1977 |
Anticonvulsant drug actions on in vitro and in vivo levels of cyclic AMP in the mouse brain.
Topics: Adenosine; Animals; Anticonvulsants; Brain; Carbamazepine; Cerebellum; Cerebral Cortex; Clonazepam; Culture Techniques; Cyclic AMP; Diazepam; Male; Mice; Norepinephrine; Ouabain; Pentylenetetrazole; Phenobarbital; Phenytoin; Potassium; Premedication; Seizures | 1979 |
Evidence for an involvement of GABA in the mediation of the cerebellar cGMP decrease and the anticonvulsant action diazepam.
Topics: Aminobutyrates; Animals; Anti-Anxiety Agents; Anticonvulsants; Barbiturates; Cerebellum; Cyclic AMP; Cyclic GMP; Diazepam; Drug Interactions; gamma-Aminobutyric Acid; Isoniazid; Male; Pentylenetetrazole; Phenytoin; Picrotoxin; Rats; Strychnine | 1975 |
Changes in seizure susceptibility after intracerebral treatment with 5,7-dihydroxytryptamine: role of serotonergic neurons.
Topics: 5,7-Dihydroxytryptamine; Acetazolamide; Animals; Anticonvulsants; Dihydroxytryptamines; Electroshock; Male; Neurons; Pentylenetetrazole; Phenobarbital; Phenytoin; Raphe Nuclei; Rats; Seizures; Serotonin | 1978 |
Effect of tryptophol on pentylenetetrazol and picrotoxin induced convulsion in mice.
Topics: Animals; Anticonvulsants; Brain; Indoles; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Phenytoin; Picrotoxin; Seizures | 1979 |
A study of the mechanism of hibernation.
Topics: Animals; Body Temperature; Body Temperature Regulation; Chiroptera; Female; Hibernation; Light; Male; Pentylenetetrazole; Phenytoin | 1979 |
Effects of 3-trifluoromethyl-alpha-ethylbenzhydrol (RGH-3332), a new enzyme inducer, on the microsomal drug metabolism. Part I.
Topics: Animals; Ascorbic Acid; Benzhydryl Compounds; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethylmorphine; Female; Hydroquinones; Hypnotics and Sedatives; Microsomes, Liver; Muscle Relaxants, Central; Pentylenetetrazole; Pharmaceutical Preparations; Phenytoin; Rats | 1978 |
Effects of phenytoin on sympathetic reflex responses in the cat.
Topics: Animals; Blood Pressure; Cats; Dimethylphenylpiperazinium Iodide; Evoked Potentials; Female; In Vitro Techniques; Male; Nictitating Membrane; Ouabain; Pentylenetetrazole; Phenytoin; Picrotoxin; Reflex; Scopolamine; Sympathetic Nervous System | 1978 |
Action of anticonvulsants on pentylenetetrazol-induced epileptiform activity on invertebrate neurones (Helix aspersa).
Topics: Action Potentials; Amobarbital; Animals; Anticonvulsants; Diazepam; Epilepsy; Helix, Snails; In Vitro Techniques; Neurons; Pentylenetetrazole; Phenytoin; Trimethadione | 1978 |
Elevation of seizure thresholds: a comparison of cerebellar stimulation, phenobarbital, and diphenylhydantoin.
Topics: Animals; Cerebellar Cortex; Cerebral Cortex; Electric Stimulation; Electroencephalography; Male; Pentylenetetrazole; Phenobarbital; Phenytoin; Rabbits; Seizures | 1978 |
Fluorinated phenytoin anticonvulsant analogs.
Topics: Animals; Anticonvulsants; Electroshock; Male; Methods; Mice; Pentylenetetrazole; Phenytoin; Postural Balance; Structure-Activity Relationship; Time Factors | 1979 |
The photically evoked afterdischarge: a model for the study of drugs useful in the treatment of petit mal epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Absence; Evoked Potentials; Female; Pentylenetetrazole; Phenytoin; Rats; Sodium Chloride; Trimethadione; Valproic Acid | 1976 |
Convulsant-anticonvulsant interactions on seizure activity and cortical acetylcholine release.
Topics: Acetylcholine; Animals; Anticonvulsants; Bicuculline; Blood Pressure; Cerebral Cortex; Convulsants; Drug Interactions; Electroencephalography; Male; Pentylenetetrazole; Phenobarbital; Phenytoin; Rats; Seizures; Time Factors; Trimethadione | 1977 |
The influences of phenytoin on the fundamental electrical properties of simple neural systems.
Topics: Action Potentials; Animals; Anura; Astacoidea; Electrophysiology; Mechanoreceptors; Membrane Potentials; Mollusca; Neural Inhibition; Neuromuscular Junction; Neurons; Ouabain; Pentylenetetrazole; Phenytoin | 1977 |
The convulsive profile of Cicuta douglasii (water hemlock).
Topics: Animals; Anticonvulsants; Convulsants; Electroshock; Male; Mice; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Plant Extracts | 1976 |
[Automatism (author's transl)].
Topics: Automatism; Brain; Carbamazepine; Electroencephalography; Humans; Pentylenetetrazole; Phenytoin; Sclerosis | 1976 |
Anticonvulsants. 5. Derivatives of 5-ethyl-5-phenylhydantoin and 5,5-diphenylhydantoin.
Topics: Animals; Anticonvulsants; Depression, Chemical; Electroshock; Hydantoins; Lethal Dose 50; Male; Mice; Motor Activity; Pentylenetetrazole; Phenytoin; Reflex; Seizures; Sleep | 1975 |
Anticonvulsant activities of delta-8 and delta-9 tetrahydrocannabinol and uridine.
Topics: Animals; Anticonvulsants; Cannabis; Dronabinol; Electroshock; Male; Mice; Pentylenetetrazole; Phenobarbital; Phenytoin; Plant Extracts; Seizures; Uridine | 1975 |
Anticonvulsive properties of cinnarizine and flunarizine in rats and mice.
Topics: Animals; Anticonvulsants; Cinnarizine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electroshock; Female; Lethal Dose 50; Male; Mice; Pentylenetetrazole; Phenobarbital; Phenytoin; Piperazines; Rats; Seizures; Time Factors | 1975 |
Anticonvulsant activity of delta9-tetrahydrocannabinol compared with three other drugs.
Topics: Animals; Anticonvulsants; Cannabis; Chlordiazepoxide; Dronabinol; Electroshock; Male; Mice; Nicotine; Pentylenetetrazole; Pharmaceutical Vehicles; Phenobarbital; Phenytoin; Seizures; Strychnine; Time Factors | 1976 |
Anticonvulsant action of lamotrigine during ontogenesis in rats.
Topics: Aging; Animals; Anticonvulsants; Epilepsy, Tonic-Clonic; Injections, Intraperitoneal; Lamotrigine; Male; Motor Activity; Pentylenetetrazole; Phenytoin; Rats; Rats, Wistar; Seizures; Triazines | 1992 |
The investigation of antiepileptic action of qingyangshen (QYS)--effect of QYS on the concentrations of neuropeptides in rat brain.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Drugs, Chinese Herbal; Male; Neuropeptides; Pentylenetetrazole; Phenytoin; Rats; Rats, Inbred Strains; Seizures; Somatostatin; Substance P | 1991 |
Effects of pharmacological manipulation of GABAergic neurotransmission in a new mutant hamster model of paroxysmal dystonia.
Topics: Animals; Baclofen; Carbamazepine; Cricetinae; Diazepam; Disease Models, Animal; Dystonia; gamma-Aminobutyric Acid; Mesocricetus; Mutation; Pentylenetetrazole; Phenobarbital; Phenytoin; Synaptic Transmission; Valproic Acid | 1991 |
Changes in seizure threshold and aggression during chronic treatment with three anticonvulsants and on drug withdrawal.
Topics: Aggression; Animals; Anticonvulsants; Lorazepam; Male; Mice; Pentylenetetrazole; Phenobarbital; Phenytoin; Seizures; Social Behavior; Substance Withdrawal Syndrome | 1990 |
Effect of phenytoin on intracellular calcium and intracellular protein changes during pentylenetetrazole-induced bursting activity in snail neurons.
Topics: Animals; Calcium; Intracellular Membranes; Ion Channels; Membrane Potentials; Neurons; Pentylenetetrazole; Phenytoin; Proteins; Snails | 1985 |
Improved anticonvulsant activity of phenytoin by a redox brain delivery system. III: Brain uptake and pharmacological effects.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Injections, Intravenous; Kidney; Liver; Male; Nervous System Diseases; Pentylenetetrazole; Phenytoin; Rats; Rats, Inbred Strains; Tissue Distribution | 1989 |
Inhibitory effect of phenytoin on intracellular cyclic nucleotide and calcium changes during pentylenetetrazole-induced bursting activity in snail neurons.
Topics: Action Potentials; Animals; Calcium; Cyclic AMP; In Vitro Techniques; Neurons; Pentylenetetrazole; Phenytoin; Snails | 1985 |
Anticonvulsant activity of piperidinol and (dialkylamino)alkanol esters.
Topics: Amino Alcohols; Animals; Anticonvulsants; Ataxia; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Diazepam; Electroshock; Esters; Muscimol; Pentylenetetrazole; Phenytoin; Piperidines; Rats; Receptors, GABA-A; Structure-Activity Relationship | 1986 |
Antiepileptic effects of globulin-N, an intact human immunoglobulin and its tissue-distribution in kindled cats.
Topics: Amygdala; Animals; Anticonvulsants; Autoradiography; Cats; Drug Combinations; Epilepsy; Half-Life; Immunochemistry; Immunoglobulin A; Immunoglobulin G; Immunoglobulins, Intravenous; Kindling, Neurologic; Ovum; Pentylenetetrazole; Phenobarbital; Phenytoin; Time Factors; Tissue Distribution | 1986 |
A possible role for spinal noradrenaline in the mechanisms of 6-hydroxydopamine against pentylenetetrazol induced convulsions in rats.
Topics: Animals; Female; Hydroxydopamines; Male; Norepinephrine; Oxidopamine; Pentylenetetrazole; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Seizures; Spinal Cord | 1988 |
Changes in GABA content of the brain and sensitivity to GABA-antagonists during and after repetitive treatment of rats with diphenilhydantoin.
Topics: Animals; Brain; Electroshock; GABA Antagonists; gamma-Aminobutyric Acid; Male; Pentylenetetrazole; Phenytoin; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1988 |
Effect of dihydropyridines and diphenylalkylamines on pentylenetetrazol-induced seizures and cerebral blood flow in cats.
Topics: Animals; Anticonvulsants; Brain; Calcium Channel Blockers; Cats; Cerebrovascular Circulation; Clonazepam; Electroencephalography; Female; Male; Nimodipine; Pentylenetetrazole; Phenytoin; Seizures; Verapamil | 1987 |
Effects of diazepam, pentobarbital, phenytoin and pentylenetetrazol on hippocampal paired-pulse inhibition in vivo.
Topics: Action Potentials; Animals; Behavior, Animal; Diazepam; Electroshock; gamma-Aminobutyric Acid; Hippocampus; Injections, Intraperitoneal; Male; Neural Inhibition; Pentobarbital; Pentylenetetrazole; Phenytoin; Rats; Rats, Inbred Strains; Seizures | 1986 |
Anticonvulsant activity of 2- and 3-aminobenzanilides.
Topics: Anilides; Aniline Compounds; Animals; Anticonvulsants; Electroshock; Male; Mice; Pentylenetetrazole; Phenobarbital; Phenytoin; Seizures | 1986 |
Differentiation of alcohol and barbital physical dependence.
Topics: Animals; Barbital; Barbiturates; Diazepam; Ethanol; Ethosuximide; Male; Mice; Morphine; Naloxone; Pentylenetetrazole; Phenytoin; Substance Withdrawal Syndrome | 1986 |
Effect of stimulus intensity on the profile of anticonvulsant activity of phenytoin, ethosuximide and valproate.
Topics: Animals; Anticonvulsants; Bicuculline; Electroshock; Ethosuximide; Male; Mice; Pentylenetetrazole; Phenytoin; Picrotoxin; Seizures; Valproic Acid | 1985 |
Comparison of anticonvulsive properties of eboracin and phenytoin in mice.
Topics: Animals; Anticonvulsants; Indenes; Lethal Dose 50; Male; Mice; Myoclonus; Pentylenetetrazole; Phenytoin; Seizures | 1985 |
Anticonvulsant effects of chronic treatment with phenytoin against pentylenetetrazole-induced seizures in the mouse.
Topics: Animals; Convulsants; Diazepam; Drug Synergism; Drug Therapy, Combination; Humans; Male; Mice; Pentylenetetrazole; Phenytoin; Seizures | 1985 |
Comparative convulsant activity of various penicillins after intracerebral injection in mice.
Topics: Ampicillin; Animals; Cephaloridine; Drug Synergism; Hydrogen-Ion Concentration; Injections; Male; Methicillin; Mice; Penicillin G; Penicillin V; Penicillinase; Penicillins; Pentylenetetrazole; Phenobarbital; Phenytoin; Potassium; Seizures; Sodium | 1973 |
Anticonvulsant effect of 5-ethyl,5-phenyl,2-pyrrolidinone and its possible relationship to gamma-aminobutyric acid-dependent inhibitory mechanisms.
Topics: Aminobutyrates; Animals; Anticonvulsants; Behavior, Animal; Central Nervous System Stimulants; Drug Synergism; Excitatory Amino Acid Antagonists; Hydrazones; Male; Mice; Motor Activity; Pentylenetetrazole; Phenytoin; Pyridoxal Phosphate; Pyrrolidinones; Reflex; Seizures; Sleep; Strychnine; Thiosemicarbazones; Time Factors | 1973 |
Alkylation reactions of hydantoins and succinimides.
Topics: Alkylation; Animals; Anticonvulsants; Benzyl Compounds; Chemical Phenomena; Chemistry; Ethosuximide; Hydantoins; Magnetic Resonance Spectroscopy; Male; Mice; Nitro Compounds; Pentylenetetrazole; Phenytoin; Spectrophotometry, Infrared; Succinimides | 1973 |
Anticonvulsant testing with a new analeptic convulsant: N-sulfamoyl-hexahydro-azepine (Sah 41-178).
Topics: Acetamides; Animals; Anticonvulsants; Azepines; Central Nervous System Stimulants; Chlordiazepoxide; Chlorpromazine; Diazepam; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electroshock; Glutethimide; Haloperidol; Male; Mice; Pentylenetetrazole; Phenobarbital; Phenytoin; Strychnine; Sulfonamides; Trimethadione | 1973 |
The developing animal as a model.
Topics: Age Factors; Animals; Barbiturates; Brain; Central Nervous System; Electric Stimulation; Electroshock; Fetus; Pentylenetetrazole; Phenytoin; Picrotoxin; Rats; Reflex; Seizures; Spinal Cord; Strychnine; Synaptic Transmission; Time Factors | 1969 |
[The effect of corazole, trimetin and diphenin on the postsynaptic potentials of motor neurons upon suprasegmental stimulation].
Topics: Animals; Anticonvulsants; Brain Stem; Cats; Motor Cortex; Motor Neurons; Pentylenetetrazole; Phenytoin; Red Nucleus; Reticular Formation; Synaptic Transmission; Vestibular Nuclei | 1968 |
The effect of selected drugs on the "emotional" behavior elicited via hypothalamic stimulation.
Topics: Amphetamine; Animals; Atropine; Behavior, Animal; Cats; Chlorpromazine; Depression, Chemical; Electric Stimulation; Emotions; Hypothalamus; Imipramine; Meprobamate; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Pregnanediones; Reserpine; Scopolamine; Stimulation, Chemical; Strychnine; Tremorine | 1968 |
Action of central nervous system stimulant and depressant drugs in the intact animal. 3. Dual action of 5-ethyl-5-(1,3-dimethylbutyl)barbiturate, dilantin and beta-methyl-beta-eta-propylglutarimide.
Topics: Animals; Anticonvulsants; Barbiturates; Bemegride; Central Nervous System; Central Nervous System Stimulants; Depression, Chemical; Drug Antagonism; Hypnotics and Sedatives; Mice; Pentobarbital; Pentylenetetrazole; Phenytoin; Piperidines; Sensory Receptor Cells; Stimulation, Chemical; Trimethadione | 1967 |
Increased susceptibility of mice to seizures after some anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Bemegride; Central Nervous System Stimulants; Drug Synergism; Electroshock; Ethionine; Female; Hydantoins; Male; Methods; Mice; Oxazines; Pentylenetetrazole; Phenobarbital; Phenytoin; Primidone; Rats; Seizures; Trimethadione | 1967 |
Action of central nervous system stimulant and depressant drugs in the intact animal. 4. Surface activity of drugs with central stimulant depressant, or dual stimulant-depressant action.
Topics: Air; Amobarbital; Barbiturates; Central Nervous System Stimulants; Chemical Phenomena; Chemistry; Depression, Chemical; Glutarates; Hypnotics and Sedatives; Oxazines; Pentobarbital; Pentylenetetrazole; Phenytoin; Picrotoxin; Pregnanediones; Solutions; Stimulation, Chemical; Surface Properties; Surface Tension; Trimethadione | 1969 |
An experimental evaluation of the anticonvulsant activity of some antihistaminic drugs.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry; Electroshock; Female; Histamine H1 Antagonists; Male; Meclizine; Pentylenetetrazole; Phenytoin; Piperazines; Promethazine; Rats; Seizures; Triprolidine | 1969 |
Effect on pseudoconditioning of drugs with known central nervous activity.
Topics: Amobarbital; Animals; Avoidance Learning; Behavior, Animal; Caffeine; Cannabis; Chlorpromazine; Conditioning, Psychological; Depression, Chemical; Diazepam; Dibenzylchlorethamine; Female; Meprobamate; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Rats; Stimulation, Chemical; Strychnine; Trimethadione | 1974 |
Antagonism of pentylenetetrazol excitation by anticonvulsants on single brain stem neurons.
Topics: Animals; Anticonvulsants; Brain Stem; Cats; Decerebrate State; Diazepam; Drug Antagonism; In Vitro Techniques; Microelectrodes; Neurons; Pentobarbital; Pentylenetetrazole; Phenytoin; Stereotaxic Techniques; Time Factors; Trimethadione | 1972 |
[Effects of various pharmacological agents on neocortical seizure activities in the rabbit].
Topics: Aminobutyrates; Animals; Cerebral Cortex; Cocaine; Electric Stimulation; Electroencephalography; Evoked Potentials; Lidocaine; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Rabbits; Strychnine | 1972 |
A comparison of the anticonvulsant, neurotoxic and lethal effects of diphenylbarbituric acid, phenobarbital and diphenylhydantoin in the mouse.
Topics: Animals; Anticonvulsants; Barbiturates; Dose-Response Relationship, Drug; Electroshock; Lethal Dose 50; Male; Mice; Mice, Inbred Strains; Neurologic Manifestations; Pentylenetetrazole; Phenobarbital; Phenytoin; Reflex; Seizures | 1973 |
Isoquinolines. 3. 3-Aminoisoquinoline derivatives with central nervous system depressant activity.
Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents; Anticonvulsants; Behavior, Animal; Blood Pressure; Cats; Central Nervous System; Depression, Chemical; Electroshock; Heart Rate; Isoquinolines; Mice; Motor Activity; Pentylenetetrazole; Phenobarbital; Phenytoin; Structure-Activity Relationship; Strychnine | 1973 |
The effect of some anticonvulsant drugs on leptazol and bicuculline induced acetylcholine efflux from rat cerebral cortex.
Topics: Acetylcholine; Alkaloids; Animals; Anticonvulsants; Cerebral Cortex; Dioxoles; Dose-Response Relationship, Drug; Electroencephalography; Isoquinolines; Pentylenetetrazole; Phenobarbital; Phenytoin; Rats; Seizures; Trimethadione | 1973 |
Some studies on the convulsant action of folic acid.
Topics: Alkaloids; Animals; Auditory Threshold; Cerebral Ventricles; Dioxoles; Electroshock; Folic Acid; Folic Acid Antagonists; Glutamates; Injections; Injections, Intravenous; Isoquinolines; Mice; Ouabain; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Seizures; Strychnine | 1973 |
Neuropharmacology of SQ 10,996, a compound with several therapeutic indications.
Topics: Amides; Animals; Anticonvulsants; Antidepressive Agents; Anxiety; Behavior, Animal; Carbamazepine; Cats; Decerebrate State; Dibenzoxazepines; Electric Stimulation; Electroshock; Evoked Potentials; Female; Humans; Limbic System; Mice; Pentylenetetrazole; Phenytoin; Rats; Seizures; Trigeminal Nerve | 1973 |
Dependence of anticonvulsant drug action on central monoamines.
Topics: Animals; Anticonvulsants; Dopamine; Drug Interactions; Electroshock; Ethosuximide; Lethal Dose 50; Male; Mice; Mice, Inbred Strains; Norepinephrine; Pentylenetetrazole; Phenobarbital; Phenytoin; Receptors, Drug; Seizures; Serotonin; Time Factors | 1973 |
Anticonvulsant effect of 5-ethyl, 5-phenyl, 2-pyrrolidinone and its possible relationship to gamma-aminobutyric acid-dependent inhibitory mechanisms.
Topics: Alkaloids; Aminobutyrates; Animals; Anticonvulsants; Dioxoles; Hydrazones; Isoquinolines; Mice; Motor Activity; Pentylenetetrazole; Phenytoin; Pyridoxal Phosphate; Pyrrolidinones; Seizures; Semicarbazides; Strychnine; Thiones; Time Factors | 1973 |
Quantitative evaluation of the pentylenetetrazol-anticonvulsant interaction on the EEG of the cat.
Topics: Animals; Anticonvulsants; Cats; Cerebral Cortex; Computers; Drug Interactions; Electroencephalography; Hippocampus; Pentylenetetrazole; Phenobarbital; Phenytoin; Reticular Formation; Thalamus; Time Factors; Trimethadione | 1973 |
Pentylenetetrazol convulsions and brain catecholamine turnover rate in rats and mice receiving diphenylhydantoin or benzodiazepines.
Topics: Animals; Benzazepines; Body Temperature; Brain; Brain Chemistry; Catecholamines; Cerebellum; Chlordiazepoxide; Corpus Striatum; Diazepam; Dopamine; Hypothalamus; Kinetics; Male; Methyltyrosines; Mice; Norepinephrine; Pentylenetetrazole; Phenytoin; Rats; Seizures | 1973 |
Effect of seizures and anticonvulsant agents on hippocampal RNA concentration.
Topics: Anesthesia, General; Animals; Anticonvulsants; Cannabis; Cerebral Cortex; Depression, Chemical; Electric Stimulation; Electroshock; Glucose; Hippocampus; Hyponatremia; Male; Pentylenetetrazole; Phenobarbital; Phenytoin; Rats; RNA; Seizures; Time Factors; Trimethadione; Urethane | 1974 |
Anticonvulsant activity of 1-alkyl-4-substituted 3,5-pyrazolidinediones.
Topics: Alkylation; Animals; Anticonvulsants; Chemical Phenomena; Chemistry; Electroshock; Hydrazines; Magnetic Resonance Spectroscopy; Male; Malonates; Mice; Neurologic Manifestations; Pentylenetetrazole; Phenytoin; Pyrazoles; Spectrophotometry, Infrared; Succinimides; Time Factors | 1974 |
Anticonvulsant effects of cannabinoids in mice: drug interactions within cannabinoids and cannabinoid interactions with phenytoin.
Topics: Animals; Cannabis; Depression, Chemical; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Electroshock; Herb-Drug Interactions; Injections, Intraperitoneal; Male; Mice; Pentylenetetrazole; Phenobarbital; Phenytoin; Phytotherapy; Seizures; Stimulation, Chemical | 1974 |
Anticonvulsant properties of cannabidiol.
Topics: Animals; Anticonvulsants; Body Temperature; Cannabis; Cold Temperature; Dronabinol; Drug Interactions; Drug Synergism; Electroshock; Hindlimb; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Phenobarbital; Phenytoin; Temperature; Time Factors | 1974 |
The hyperexcitable neuron as a model for the laboratory analysis of anticonvulsant drugs.
Topics: Acetazolamide; Action Potentials; Aluminum; Animals; Behavior, Animal; Cats; Cerebral Cortex; Electroencephalography; Haplorhini; Hydroxides; Models, Biological; Neurons; Pentylenetetrazole; Phenobarbital; Phenytoin; Seizures; Time Factors; Trimethadione | 1969 |
Pharmacological and biochemical studies on 2-amino-4-phenylsulphonylbenzenesulphonamide (NSD 3004): a new sulphonamide with anticonvulsant and carbonic anhydrase inhibitory properties.
Topics: Animals; Anticonvulsants; Carbonic Anhydrase Inhibitors; Diuresis; Electroshock; Enzyme Activation; Lethal Dose 50; Mice; Pentylenetetrazole; Phenobarbital; Phenytoin; Rats; Seizures; Strychnine; Sulfonamides | 1971 |
Metrazol test for rapid screening of anticonvulsants.
Topics: Animals; Anticonvulsants; Electroshock; Injections, Subcutaneous; Mice; Pentylenetetrazole; Phenytoin; Seizures; Trimethadione | 1969 |
[Influence of food deprivation on efficacy and toxicity of drugs in mice].
Topics: Acetates; Aminopyrine; Analgesics; Animals; Anticonvulsants; Blood Glucose; Blood Proteins; Body Weight; Carrageenan; Cholesterol; Citrates; Female; Male; Methylcellulose; Mice; Oxyphenbutazone; Pectins; Pentobarbital; Pentylenetetrazole; Pharmacology; Phenytoin; Starvation; Time Factors; Toxicology | 1969 |
Discharge patterns of single reticular neuron synchronized with electrocortical spike induced by pentetrazol.
Topics: Animals; Electroencephalography; Female; Hexobarbital; Injections, Intravenous; Lidocaine; Male; Neurons; Pentylenetetrazole; Phenytoin; Rats; Reticular Formation | 1970 |
Pharmacologic interactions of albutoin with other anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Drug Synergism; Electroshock; Hydantoins; Male; Mice; Pentylenetetrazole; Phenobarbital; Phenytoin; Seizures; Trimethadione | 1970 |
Anticonvulsant drugs and self-stimulation rates in rats.
Topics: Acetazolamide; Animals; Chlordiazepoxide; Electrodes; Male; Meprobamate; Pentobarbital; Pentylenetetrazole; Phenobarbital; Phenytoin; Placebos; Rats; Seizures; Self Stimulation | 1970 |
[Anticonvulsant action of imipramine and imitriptyline associated with phenobarbital, phenytoin and diazepam].
Topics: Amitriptyline; Animals; Anticonvulsants; Diazepam; Electroshock; Imipramine; Mice; Pentylenetetrazole; Phenobarbital; Phenytoin; Seizures | 1970 |
Anticonvulsant properties of diphenylthiohydantoin.
Topics: Animals; Drug Antagonism; Electroencephalography; Electroshock; Hindlimb; Male; Myoclonus; Pentylenetetrazole; Phenytoin; Rats; Seizures; Sulfides | 1970 |
Synthesis and anticonvulsant activity of substituted 2-thioquinazolin-4-ones. I. Preliminary studies.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry; Electroshock; Male; Mice; Pentylenetetrazole; Phenobarbital; Phenytoin; Quinazolines; Seizures | 1971 |
A comparison of the anticonvulsant properties of 2-diethylaminopento-4-ynoyl-2',6'-xylidide (WY 21745) with lignocaine, phenytoin, phenobarbitone and trimethadione.
Topics: Anesthetics, Local; Animals; Anticonvulsants; Drug Antagonism; Electroshock; Lethal Dose 50; Lidocaine; Mice; Oxazoles; Pentylenetetrazole; Phenobarbital; Phenytoin; Seizures; Trimethadione | 1971 |
Substitution in the hydantoin ring. VII. N-3-Propionic acid and its ethyl ester and N-3-(2-cyanoethyl) derivatives.
Topics: Alkylation; Animals; Drug Synergism; Electroshock; Hexobarbital; Hydantoins; Infrared Rays; Magnetic Resonance Spectroscopy; Male; Mice; Motor Activity; Pentylenetetrazole; Phenytoin; Propionates; Spectrum Analysis; Ultraviolet Rays | 1968 |
Influence of several drugs on the in vivo and in vitro activity of mammalian hepatic azo-reductase.
Topics: Animals; Caffeine; Guanethidine; Guinea Pigs; In Vitro Techniques; Iproniazid; Isoniazid; Liver; Nitrofurantoin; Oxidoreductases; Pentylenetetrazole; Phenobarbital; Phenylbutazone; Phenytoin; Rabbits; Rats; Sulfinpyrazone; Sulfonic Acids; Trimethadione | 1968 |
Toxicity of methylimidazoles.
Topics: Animals; Anticonvulsants; Chickens; Chlordiazepoxide; Electroencephalography; Heart Rate; Imidazoles; Mice; Motor Activity; Pentobarbital; Pentylenetetrazole; Phenytoin; Pyrazines; Rabbits; Respiration; Respiratory Paralysis; Seizures | 1969 |
[Comparative studies on the anticonvulsant activity of the pyrone compounds of Piper methysticum Forst].
Topics: Animals; Anticonvulsants; Injections, Intraperitoneal; Injections, Intravenous; Intestinal Absorption; Male; Mephenesin; Mice; Pentylenetetrazole; Phenobarbital; Phenytoin; Plant Extracts; Plants; Procaine; Pyrans; Reserpine; Shock; Time Factors | 1969 |
Drug effects on the spontaneous electrical activity of the squid giant axon.
Topics: Acetylcholine; Action Potentials; Animals; Anticonvulsants; Atropine; Axons; Barbiturates; Bromides; Chloroform; Chlorpheniramine; Chlorpromazine; Curare; Dopamine; Electrophysiology; Ethanol; Ethers; Evoked Potentials; Hydantoins; Mollusca; Muscles; Nortropanes; Parasympatholytics; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Procaine; Serotonin; Strychnine; Tetracaine; Tremorine; Trihexyphenidyl; Trimethadione | 1967 |
The effect of dieldrin (HEOD) on chronaxie and convulsion thresholds in rats and mice.
Topics: Animals; Chronaxy; Dieldrin; Dimethyl Sulfoxide; In Vitro Techniques; Mice; Nervous System; Pentylenetetrazole; Phenytoin; Phrenic Nerve; Rats; Seizures; Strychnine; Tetany | 1967 |
A comparison of the convulsant activity of procaine and pentylenetetrazol.
Topics: Animals; Anticonvulsants; Chlorpromazine; Dibenzylchlorethamine; Female; Hydroxybutyrates; Mice; Pentobarbital; Pentylenetetrazole; Phenobarbital; Phenytoin; Procaine; Reflex; Reserpine; Seizures | 1967 |
Puromycin effect on memory may be due to occult seizures.
Topics: Amnesia; Animals; Behavior, Animal; Brain; Cycloheximide; Drug Antagonism; Humans; Memory; Mice; Nerve Tissue Proteins; Pentylenetetrazole; Phenytoin; Psychopharmacology; Puromycin; Seizures | 1967 |
[Anticonvulsant action of di-N-propylacetate combined with benzodiazepines, phenobarbital and phenytoin].
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Diazepam; Drug Therapy, Combination; Male; Mice; Pentylenetetrazole; Phenobarbital; Phenytoin; Seizures; Semicarbazides; Valproic Acid | 1981 |
Effects of combined treatment with diphenylhydantoin and different benzodiazepines on pentylenetetrazol- and bicuculline-induced seizures in mice.
Topics: Animals; Anti-Anxiety Agents; Bicuculline; Chlordiazepoxide; Clonazepam; Dose-Response Relationship, Drug; Male; Muridae; Nitrazepam; Pentylenetetrazole; Phenytoin; Seizures | 1982 |
[Pharmacology of a 1H-1, 2, 4-triazolyl benzophenone derivative (450191-S), a new sleep-inducer (III). Behavioral study on interactions of 450191-S and other drugs in mice].
Topics: Aminopyrine; Animals; Anti-Anxiety Agents; Apomorphine; Behavior, Animal; Benzodiazepines; Central Nervous System; Central Nervous System Agents; Haloperidol; Hypnotics and Sedatives; Imipramine; Male; Mice; Pentylenetetrazole; Phenytoin; Reserpine; Triazoles | 1984 |
Excitatory and depressant effects of delta 9-tetrahydrocannabinol and cannabidiol on cortical evoked responses in the conscious rat.
Topics: Animals; Anticonvulsants; Cannabidiol; Cannabinoids; Cerebral Cortex; Convulsants; Dronabinol; Ethosuximide; Evoked Potentials; Pentylenetetrazole; Phenytoin; Rats; Rats, Inbred Strains | 1981 |
Glycine potentiates the action of some anticonvulsant drugs in some seizure models.
Topics: 3-Mercaptopropionic Acid; Acoustic Stimulation; Animals; Anticonvulsants; Disease Models, Animal; Drug Synergism; Glycine; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Pentylenetetrazole; Phenobarbital; Phenytoin; Seizures; Valproic Acid | 1984 |
Kinetics of drug action in disease states III: Effect of pregnancy on the relationship between phenytoin concentration and antiseizure activity in rats.
Topics: Electroshock; Female; Humans; Kinetics; Pentylenetetrazole; Phenytoin; Pregnancy; Pregnancy Complications; Seizures | 1984 |
Hippocampal calcium-binding protein during commissural kindling-induced epileptogenesis: progressive decline and effects of anticonvulsants.
Topics: Animals; Calcium-Binding Proteins; Diazepam; Hippocampus; Kindling, Neurologic; Male; Pentylenetetrazole; Phenytoin; Rats; Rats, Inbred Strains; Seizures | 1984 |
Inhibition of pentylenetetrazol induced genetically-determined stereotypic convulsions in tottering mutant mice by diazepam.
Topics: Animals; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Female; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Pentylenetetrazole; Phenytoin; Seizures; Stereotyped Behavior | 1983 |
Electroshock raises pentylenetetrazol threshold: possible role of inosine.
Topics: Animals; Electroshock; Hypoxanthines; Inosine; Male; Mice; Mice, Inbred BALB C; Pentylenetetrazole; Phenytoin; Seizures | 1983 |
Effects of carbamazepine and diphenylhydantoin on metrazol seizures during ontogenesis in rats.
Topics: Aging; Animals; Carbamazepine; Male; Pentylenetetrazole; Phenytoin; Rats; Rats, Inbred Strains; Seizures | 1983 |
Effect of eboracin on convulsive seizures in mice: enhancement of myoclonus and inhibition of the tonic phase.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Electroshock; Indenes; Male; Mice; Myoclonus; Pentylenetetrazole; Phenytoin; Seizures | 1982 |
Eboracin: a substituted indenopyrrole active against metrazol-induced, audiogenic and electroshock seizures in mice.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Indenes; Mice; Mice, Inbred Strains; Muridae; Pentylenetetrazole; Phenytoin; Seizures | 1982 |
Diphenylhydantoin potentiates the protective effect of diazepam against pentylenetetrazol but not against bicuculline and isoniazid-induced seizures in mice.
Topics: Animals; Bicuculline; Diazepam; Drug Synergism; Isoniazid; Male; Mice; Pentylenetetrazole; Phenytoin; Seizures | 1981 |
Effect of diphenylhydantoin, granatane-3-spiro-5'-hydantoin and leptazol on mouse brain glutamate dehydrogenase, urea and ammonia levels in brain.
Topics: Ammonia; Animals; Brain; Drug Interactions; Glutamate Dehydrogenase; Hydantoins; Mice; Mice, Inbred ICR; Pentylenetetrazole; Phenytoin; Urea | 1981 |
[Phenytoin and ethyl alcohol interactions in rats with regard to their effect on the central nervous system after single dose administration].
Topics: Animals; Drug Interactions; Ethanol; Male; Pentylenetetrazole; Phenytoin; Rats; Seizures | 1981 |
Anticonvulsant properties of selected pyrrolo[2,3-d]pyrimidine-2,4-diones and intermediates.
Topics: Animals; Anticonvulsants; Electroshock; Male; Mice; Pentylenetetrazole; Phenytoin; Pyrimidinones; Pyrroles; Seizures; Solubility; Structure-Activity Relationship; Trimethadione | 1980 |
Comparative anticonvulsant activity and neurotoxicity of 4-amino-N-(2,6-dimethylphenyl)phthalimide and prototype antiepileptic drugs in mice and rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Carbamazepine; Drug Evaluation, Preclinical; Electroshock; Injections, Intraperitoneal; Injections, Subcutaneous; Mice; Mice, Inbred Strains; Nervous System; Pentylenetetrazole; Phenytoin; Phthalimides; Rats; Rats, Sprague-Dawley; Seizures; Strychnine | 1995 |
Anticonvulsant activity of phenytoin-lipid conjugates, a new class of phenytoin prodrugs.
Topics: Administration, Oral; Animals; Anticonvulsants; Dimethyl Sulfoxide; Electroshock; Hydrolysis; In Vitro Techniques; Injections, Subcutaneous; Lipase; Lipid Metabolism; Lipids; Male; Mice; Pancreas; Pentylenetetrazole; Phenytoin; Prodrugs; Reference Standards; Seizures; Structure-Activity Relationship | 1995 |
Anticonvulsant activity of Casimiroa edulis in comparison to phenytoin and phenobarbital.
Topics: Administration, Oral; Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Injections, Subcutaneous; Male; Mexico; Pentylenetetrazole; Phenobarbital; Phenytoin; Plant Extracts; Plant Leaves; Rats; Rats, Wistar; Seizures | 1995 |
Structural and electronic conditions for anticonvulsant activity of bicyclic hydantoin derivatives.
Topics: Anticonvulsants; Crystallography, X-Ray; Electroshock; Hydantoins; Pentylenetetrazole; Phenytoin; Stereoisomerism; Structure-Activity Relationship | 1995 |
Leptazol-induced seizures.
Topics: Adult; Epilepsy, Tonic-Clonic; Humans; Male; Pentylenetetrazole; Phenytoin | 1994 |
Differential action of phenytoin and carbamazepine on cortical interhemispheric responses in young but not in adult rats.
Topics: Aging; Analysis of Variance; Animals; Carbamazepine; Electric Stimulation; Epilepsy, Tonic-Clonic; Male; Pentylenetetrazole; Phenytoin; Rats; Rats, Wistar; Somatosensory Cortex | 1993 |
Protective effect of flunarizine and nifedipine alone and in combination with anticonvulsant drugs against PTZ-induced seizures in mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Interactions; Ethosuximide; Female; Flunarizine; Male; Mice; Nifedipine; Pentylenetetrazole; Phenytoin; Seizures | 1993 |
The comparison of anticonvulsant properties of commercial diphenylhydantoin (DPH) and its 3-amino-derivative (3-amino-DPH).
Topics: Administration, Oral; Animals; Anticonvulsants; Bicuculline; Injections, Intraperitoneal; Lethal Dose 50; Mice; Pentylenetetrazole; Phenytoin; Psychomotor Performance; Strychnine | 1993 |
3-Hydroxymethylphenytoin valproic acid ester, a new prodrug combining two anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Convulsants; Electroshock; Mice; Pentylenetetrazole; Phenytoin; Prodrugs; Rats; Valproic Acid | 1996 |
Anticonvulsant and neurotoxicological properties of 4-amino-N-(2-ethylphenyl)benzamide, a potent ameltolide analogue.
Topics: Administration, Oral; Animals; Anticonvulsants; Benzamides; Convulsants; Dose-Response Relationship, Drug; Electroshock; Injections, Intraperitoneal; Male; Mice; Mice, Inbred Strains; Nervous System; Pentylenetetrazole; Phenytoin; Rats; Rats, Sprague-Dawley; Seizures | 1997 |
Chinese herb constituent beta-eudesmol alleviated the electroshock seizures in mice and electrographic seizures in rat hippocampal slices.
Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Drugs, Chinese Herbal; Electroshock; Hippocampus; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Phenytoin; Picrotoxin; Potassium; Rats; Seizures; Sesquiterpenes, Eudesmane; Terpenes | 1997 |
Anticonvulsant effects of nimodipine and two novel dihydropyridines (PCA 50922 and PCA 50941) against seizures elicited by pentylenetetrazole and electroconvulsive shock in mice.
Topics: Animals; Anticonvulsants; Calcium Channel Agonists; Calcium Channel Blockers; Clonazepam; Dihydropyridines; Electroshock; Female; Male; Mice; Mice, Inbred Strains; Nimodipine; Pentylenetetrazole; Phenytoin; Seizures; Thiazoles | 1998 |
Additive anticonvulsant effect of flunarizine and sodium valproate on electroshock and chemoshock induced seizures in mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Interactions; Drug Synergism; Drug Therapy, Combination; Electroshock; Ethosuximide; Flunarizine; Male; Mice; Motor Activity; Pentylenetetrazole; Phenytoin; Seizures; Valproic Acid | 1998 |
Cerebral seizure susceptibility and patterns of paroxysmal activity during embryonic development in the domestic chicken.
Topics: Animals; Anticonvulsants; Chick Embryo; Convulsants; Electroencephalography; Glutamic Acid; Methionine Sulfoximine; Ouabain; Pentylenetetrazole; Phenytoin; Seizures | 1973 |
Casimiroa edulis seed extracts show anticonvulsive properties in rats.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Male; Mexico; Pentylenetetrazole; Phenobarbital; Phenytoin; Plant Extracts; Prohibitins; Propylene Glycol; Rats; Rats, Wistar; Solubility; Time Factors | 1999 |
Synthesis and anticonvulsant and neurotoxic properties of substituted N-phenyl derivatives of the phthalimide pharmacophore.
Topics: Administration, Oral; Animals; Anticonvulsants; Batrachotoxins; Cerebral Cortex; Convulsants; Electroshock; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; In Vitro Techniques; Ion Channel Gating; Kainic Acid; Magnesium Deficiency; Mice; N-Methylaspartate; Patch-Clamp Techniques; Pentylenetetrazole; Phenytoin; Phthalimides; Rats; Seizures; Sodium Channel Blockers; Structure-Activity Relationship; Synaptosomes; Tumor Cells, Cultured | 2000 |
Functionalized amino acid anticonvulsants: synthesis and pharmacological evaluation of conformationally restricted analogues.
Topics: Amino Acids; Animals; Anticonvulsants; Catalysis; Crystallography, X-Ray; Cyclization; Drug Design; Hydantoins; Lactams; Magnetic Resonance Spectroscopy; Male; Mice; Molecular Conformation; Molecular Structure; Neuroblastoma; Pentylenetetrazole; Phenobarbital; Phenytoin; Proline; Rats; Seizures; Sodium Channels; Stereoisomerism; Structure-Activity Relationship; Tetrazoles; Tumor Cells, Cultured | 2001 |
Comparison of the anticonvulsant efficacies and neurotoxic effects of valproic acid, phenytoin, and the ketogenic diet.
Topics: 3-Hydroxybutyric Acid; Animals; Anticonvulsants; Dietary Fats; Electroencephalography; Energy Intake; Male; Pentylenetetrazole; Phenytoin; Rats; Rats, Sprague-Dawley; Seizures; Treatment Outcome; Valproic Acid | 2001 |
Anticonvulsant activity of the leaf essential oil of Laurus nobilis against pentylenetetrazole- and maximal electroshock-induced seizures.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Laurus; Male; Mice; Pentylenetetrazole; Phenytoin; Phytotherapy; Plant Leaves; Plant Oils; Seizures | 2002 |
[Analysis of diphenylhydantoin in electroshock and metrazol shock].
Topics: Convulsive Therapy; Electroshock; Hydantoins; Pentylenetetrazole; Phenytoin; Shock | 1952 |
STIMULANT ACTION OF PYRIDYL DERIVATIVES OF BENZODIOXANS AND BENZODIOXEPANS.
Topics: Animals; Anticonvulsants; Atropine; Bemegride; Central Nervous System Agents; Central Nervous System Stimulants; Chlorisondamine; Chlorpromazine; Diazepam; Mephenesin; Meprobamate; Mice; Pentylenetetrazole; Pharmacology; Phenobarbital; Phenytoin; Picrotoxin; Research; Seizures; Strychnine; Tranquilizing Agents | 1963 |
ANTIMALARIALS AND OTHER ANTICONVULSANT DRUGS: PREDICTIVE VALIDITY OF LABORATORY TESTS.
Topics: Animals; Anticonvulsants; Antimalarials; Chloroquine; Electric Stimulation; Hydroxychloroquine; Mice; Pentylenetetrazole; Pharmacology; Phenobarbital; Phenytoin; Quinacrine; Research; Seizures | 1964 |
ELECTROCONVULSIVE RESPONSES OF RATS TO CONVULSANT AND ANTICONVULSANT DRUGS DURING ACCLIMATIZATION AT HIGH ALTITUDE (12,470 FEET, 3,800 M).
Topics: Acclimatization; Acetazolamide; Altitude; Anticonvulsants; Convulsants; Electric Stimulation; Neurophysiology; Pentylenetetrazole; Pharmacology; Phenytoin; Rats; Research; Seizures; Strychnine | 1964 |
ANTICONVULSANTS. I. DIBENZO(A,D)CYCLOHEPTADIENE-5-CARBOXAMIDE AND RELATED COMPOUNDS.
Topics: Amides; Anticonvulsants; Ataxia; Chemistry, Pharmaceutical; Mice; Pentylenetetrazole; Pharmacology; Phenobarbital; Phenytoin; Primidone; Research; Seizures; Toxicology | 1964 |
A NEUROPHARMACOLOGICAL STUDY OF GAMMA-AMINOBUTYRIC ACID (GABA).
Topics: Aminobutyrates; Anesthesia; Anesthesia, Intravenous; Behavior, Animal; Brain Chemistry; Cats; Chlorpromazine; Electroencephalography; Electroshock; gamma-Aminobutyric Acid; Hydroxylamines; Metabolism; Neuropharmacology; Pentobarbital; Pentylenetetrazole; Pharmacology; Phenytoin; Research; Reserpine; Seizures; Strychnine; Toxicology | 1964 |
NOTE ON THE INTERACTIONS OF AMPHETAMINE WITH ANTICONVULSANT DRUGS.
Topics: Amphetamine; Amphetamines; Animals; Anticonvulsants; Electricity; Electroshock; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Ethosuximide; Mice; Pentylenetetrazole; Pharmacology; Phenobarbital; Phenytoin; Research; Seizures | 1964 |
ELECTROCONVULSIVE RESPONSES OF RATS TO CONVULSANT AND ANTICONVULSANT DRUGS DURING HIGH-ALTITUDE ACCLIMATIZATION.
Topics: Acclimatization; Acetazolamide; Altitude; Anticonvulsants; Convulsants; Electricity; Electroshock; Pentylenetetrazole; Pharmacology; Phenytoin; Physiology; Rats; Research; Seizures; Strychnine; Toxicology | 1964 |
An experimental evaluation of anticonvulsant activity of Vitex-negundo.
Topics: Animals; Anticonvulsants; Drug Combinations; Drug Evaluation, Preclinical; Drug Interactions; Electroshock; Male; Pentylenetetrazole; Phenytoin; Phytotherapy; Plant Extracts; Plant Leaves; Plants, Medicinal; Rats; Rats, Wistar; Reference Standards; Seizures; Valproic Acid; Vitex | 2005 |
In vivo characterisation of the small-conductance KCa (SK) channel activator 1-ethyl-2-benzimidazolinone (1-EBIO) as a potential anticonvulsant.
Topics: Animals; Anticonvulsants; Benzimidazoles; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Levetiracetam; Male; Mice; Motor Activity; Pentylenetetrazole; Phenytoin; Pilocarpine; Piracetam; Seizures; Sensory Thresholds; Small-Conductance Calcium-Activated Potassium Channels | 2006 |
Development of a Drosophila seizure model for in vivo high-throughput drug screening.
Topics: Amino Acid Sequence; Animals; Anticonvulsants; Behavior, Animal; Cell Survival; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drosophila; Drug Evaluation, Preclinical; Electrophysiology; GABA Antagonists; GABA-A Receptor Antagonists; Larva; Pentylenetetrazole; Phenotype; Phenytoin; Picrotoxin; Seizures | 2006 |
[Influence of repeated seizures and large dosage anti-epileptic drug on phosphorylated cAMP response element binding protein in rat's hippocampus and effect of Caoguo Zhimu Decoction].
Topics: Animals; Cognition Disorders; Cyclic AMP Response Element-Binding Protein; Drugs, Chinese Herbal; Epilepsy; Hippocampus; Kindling, Neurologic; Male; Pentylenetetrazole; Phenytoin; Phosphorylation; Phytotherapy; Random Allocation; Rats; Rats, Sprague-Dawley | 2007 |
Phythochemical screening and anticonvulsant activity of Cymbopogon winterianus Jowitt (Poaceae) leaf essential oil in rodents.
Topics: Animals; Anticonvulsants; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Male; Mice; Oils, Volatile; Pentylenetetrazole; Phenytoin; Phytotherapy; Picrotoxin; Plant Leaves; Plant Oils; Poaceae; Seizures; Strychnine | 2008 |
Synthesis and anticonvulsant activity of 5-chloro-2(3H)-benzoxazolinone-3-acetyl-2-(o/p-substituted benzal) hydrazone derivatives.
Topics: Animals; Anticonvulsants; Convulsants; Epilepsy; Hydrazones; Magnetic Resonance Spectroscopy; Male; Mice; Pentylenetetrazole; Phenytoin; Postural Balance; Spectrophotometry, Infrared; Structure-Activity Relationship | 2008 |
Antiulcer and anticonvulsant activity of Croton zambesicus.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Anticonvulsants; Antipsychotic Agents; Central Nervous System Depressants; Convulsants; Croton; Ethanol; Female; Indomethacin; Male; Medicine, African Traditional; Mice; Nigeria; Pentylenetetrazole; Phenytoin; Picrotoxin; Plant Extracts; Plant Roots; Rats; Reserpine; Stomach Ulcer | 2009 |
Effect of various antiepileptic drugs in a pentylenetetrazol-induced seizure model in mice.
Topics: Adenosine; Algorithms; Animals; Anti-Inflammatory Agents; Anticonvulsants; Barbiturates; Carbamazepine; Central Nervous System Depressants; Convulsants; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Epilepsy, Tonic-Clonic; Ethanol; Infusions, Intravenous; Lactones; Male; Mice; Pentylenetetrazole; Phenytoin; Plant Extracts; Seizures; Sulfones; Withania | 2009 |
Anticonvulsant activity of DNS II fraction in the acute seizure models.
Topics: Acetone; Animals; Anticonvulsants; Delphinium; Diazepam; Epilepsy; Male; Melanoma; Mice; Mice, Inbred Strains; Pakistan; Pentylenetetrazole; Phenytoin; Picrotoxin; Ranunculaceae; Seizures; Skin Neoplasms | 2010 |
Synthesis and anticonvulsant activity of 4-oxo and 4-thioxo-8-bromobenzopyran derivatives.
Topics: Animals; Anticonvulsants; Benzopyrans; Electroshock; Indicators and Reagents; Lethal Dose 50; Male; Mice; Nervous System Diseases; Pentylenetetrazole; Phenytoin; Seizures; Stereoisomerism; Structure-Activity Relationship; Valproic Acid | 2010 |
Anticonvulsant activity of embelin isolated from Embelia ribes.
Topics: Animals; Anticonvulsants; Benzoquinones; Central Nervous System Depressants; Diazepam; Dose-Response Relationship, Drug; Electroshock; Embelia; Locomotion; Pentylenetetrazole; Phenytoin; Phytotherapy; Plant Extracts; Rats; Seizures | 2011 |
Influence of etoricoxib on anticonvulsant activity of phenytoin and diazepam in experimental seizure models in mice.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Electricity; Etoricoxib; Male; Mice; Pentylenetetrazole; Phenytoin; Pyridines; Seizures; Sulfones | 2010 |
Synthesis and anticonvulsant activity of new 1-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]pyrrolidine-2,5-diones.
Topics: Administration, Oral; Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Drug Design; Drug Evaluation, Preclinical; Electroshock; Ethosuximide; Injections, Intraperitoneal; Mice; Molecular Structure; Motor Activity; Pentylenetetrazole; Phenytoin; Piperazines; Rats; Seizures; Structure-Activity Relationship; Succinimides; Time Factors | 2011 |
Design, synthesis and protection against pentylenetetrazole-induced seizure of N-aryl derivatives of the phthalimide pharmacophore.
Topics: Amino Acids; Animals; Anticonvulsants; Catalytic Domain; Computer Simulation; Drug Design; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Mice; Models, Molecular; NAV1.2 Voltage-Gated Sodium Channel; Nitro Compounds; Pentylenetetrazole; Phenytoin; Phthalimides; Protein Structure, Tertiary; Seizures; Structure-Activity Relationship; Thermodynamics; Time Factors | 2012 |
Influence of carbenoxolone on the anticonvulsant efficacy of phenytoin in pentylenetetrazole kindled rats.
Topics: Animals; Anticonvulsants; Carbenoxolone; Convulsants; Electrodes, Implanted; Electroencephalography; Kindling, Neurologic; Male; Pentylenetetrazole; Phenytoin; Rats; Rats, Wistar; Seizures | 2012 |
Overexpression of multidrug resistance-associated protein 2 in the brain of pentylenetetrazole-kindled rats.
Topics: Analysis of Variance; Animals; Anticonvulsants; Brain; Chromatography, Liquid; Coloring Agents; Convulsants; Disease Models, Animal; Drug Interactions; Epilepsy; Kindling, Neurologic; Male; Mass Spectrometry; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Pentylenetetrazole; Phenytoin; Rats; Rats, Sprague-Dawley; Sulfobromophthalein; Time Factors; Up-Regulation | 2012 |
Anticonvulsant action of indazole.
Topics: Animals; Anticonvulsants; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Indazoles; Male; Mice; Pentylenetetrazole; Phenytoin; Seizures; Strychnine | 2013 |
Phenytoin-based bivalent ligands: design, synthesis and anticonvulsant activity.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Design; Electroshock; Female; Ligands; Male; Mice; Pentylenetetrazole; Phenytoin; Seizures; Structure-Activity Relationship | 2012 |
Antiepileptic drugs prevent changes in adenosine deamination during acute seizure episodes in adult zebrafish.
Topics: Adenine Nucleotides; Adenosine; Adenosine Deaminase; Amines; Animals; Anticonvulsants; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Female; Gabapentin; gamma-Aminobutyric Acid; Gene Expression; Male; Pentylenetetrazole; Phenytoin; Seizures; Valproic Acid; Zebrafish | 2013 |
Anticonvulsant effect of the essential oil and methanolic extracts of Zataria multiflora Boiss.
Topics: Animals; Anticonvulsants; Distillation; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electroshock; Ethosuximide; Injections, Intraperitoneal; Lamiaceae; Male; Methanol; Mice; Oils, Volatile; Pentylenetetrazole; Phenytoin; Phytotherapy; Plant Extracts; Plant Oils; Plants, Medicinal; Postural Balance; Rotarod Performance Test; Seizures; Sesame Oil; Solvents | 2013 |
A synthetic bioisoster of trimethadione and phenytoin elicits anticonvulsant effect, protects the brain oxidative damage produced by seizures and exerts antidepressant action in mice.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Brain Injuries; Disease Models, Animal; Flunitrazepam; Glutathione; Hindlimb Suspension; Lipid Peroxidation; Male; Maze Learning; Mice; Motor Activity; Pentylenetetrazole; Phenytoin; Seizures; Sodium-Potassium-Exchanging ATPase; Time Factors; Trimethadione; Veratrine | 2014 |
Pharmacoproteomics-based reconstruction of in vivo P-glycoprotein function at blood-brain barrier and brain distribution of substrate verapamil in pentylenetetrazole-kindled epilepsy, spontaneous epilepsy, and phenytoin treatment models.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Disease Models, Animal; Epilepsy; Male; Membrane Proteins; Mice; Pentylenetetrazole; Phenytoin; Proteomics; Verapamil | 2014 |
Pentylenetetrazol-induced seizure-like behavior and neural hyperactivity in the medicinal leech.
Topics: Action Potentials; Analysis of Variance; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; In Vitro Techniques; Leeches; Motor Activity; Neurons; Pentylenetetrazole; Phenytoin | 2015 |
New benzo[d]thiazol-2-yl-aminoacetamides as potential anticonvulsants: synthesis, activity and prediction of molecular properties.
Topics: Acetamides; Animals; Anticonvulsants; Benzothiazoles; Carbamazepine; Computer Simulation; Disease Models, Animal; Drug Design; Electroshock; Mice; Models, Biological; Molecular Structure; Pentylenetetrazole; Phenytoin; Seizures; Structure-Activity Relationship | 2015 |
Synergistic effect of docosahexaenoic acid on anticonvulsant activity of valproic acid and lamotrigine in animal seizure models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Docosahexaenoic Acids; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Electroshock; Epilepsy; Kindling, Neurologic; Lamotrigine; Male; Mice; Pentylenetetrazole; Phenytoin; Rats; Rats, Wistar; Seizures; Triazines; Valproic Acid | 2015 |
Protective effect on phenytoin-induced cognition deficit in pentylenetetrazol kindled mice: A repertoire of Glycyrrhiza glabra flavonoid antioxidants.
Topics: Acetates; Animals; Anticonvulsants; Antioxidants; Behavior, Animal; Brain; Cognition; Cognition Disorders; Disease Models, Animal; Flavonoids; Glycyrrhiza; Kindling, Neurologic; Lipid Peroxidation; Male; Memory; Mice; Oxidative Stress; Pentylenetetrazole; Phenytoin; Phytotherapy; Plant Extracts; Plant Roots; Plants, Medicinal; Seizures; Solvents; Time Factors | 2016 |
Reversal of P-glycoprotein overexpression by Ginkgo biloba extract in the brains of pentylenetetrazole-kindled and phenytoin-treated mice.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Caspase 3; Disease Models, Animal; Ginkgo biloba; Kindling, Neurologic; Male; Mice; Pentylenetetrazole; Phenytoin; Plant Extracts; Seizures; Verapamil | 2015 |
Modulation of brain glutamate dehydrogenase as a tool for controlling seizures.
Topics: Animals; Anticonvulsants; Brain; Deamination; Diazepam; Disease Models, Animal; Enzyme Inhibitors; Glutamate Dehydrogenase; Glutamic Acid; Ketoglutaric Acids; Male; Mice; Oxidation-Reduction; Oxygen Consumption; Pentylenetetrazole; Phenytoin; Seizures; Time Factors; Valproic Acid | 2015 |
Design, synthesis, anticonvulsant, and antiarrhythmic properties of novel N-Mannich base and amide derivatives of β-tetralinohydantoin.
Topics: Amides; Animals; Anti-Arrhythmia Agents; Anticonvulsants; Disease Models, Animal; Drug Design; Electroshock; Male; Mannich Bases; Neurotoxicity Syndromes; Pentylenetetrazole; Phenytoin; Rats; Rats, Sprague-Dawley; Rotarod Performance Test; Seizures; Structure-Activity Relationship | 2016 |
Pharmacological characterization of the cannabinoid receptor 2 agonist, β-caryophyllene on seizure models in mice.
Topics: Animals; Anticonvulsants; Cannabinoid Receptor Agonists; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Hippocampus; Kainic Acid; Male; Malondialdehyde; Maze Learning; Mice, Inbred ICR; Motor Activity; Pentylenetetrazole; Phenytoin; Polycyclic Sesquiterpenes; Receptor, Cannabinoid, CB2; Seizures; Sesquiterpenes; Status Epilepticus | 2018 |
Improving effect of mild foot electrical stimulation on pentylenetetrazole-induced impairment of learning and memory.
Topics: Animals; Electric Stimulation Therapy; Kindling, Neurologic; Male; Memory; Memory Disorders; Pentylenetetrazole; Phenytoin; Rats; Rats, Wistar; Treatment Outcome | 2018 |
Molecular mechanisms of neuroprotective effect of adjuvant therapy with phenytoin in pentylenetetrazole-induced seizures: Impact on Sirt1/NRF2 signaling pathways.
Topics: alpha-Tocopherol; Animals; Anticonvulsants; Antioxidants; Brain; Inflammation; Male; Neurons; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Pentylenetetrazole; Phenytoin; Rats, Wistar; Seizures; Signal Transduction; Sirtuin 1; Ubiquinone | 2018 |
Cunaniol-elicited seizures: Behavior characterization and electroencephalographic analyses.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Electroencephalography; Pentylenetetrazole; Phenobarbital; Phenytoin; Rats; Rats, Wistar; Seizures | 2018 |
Naringin in a combined therapy with phenytoin on pentylenetetrazole-induced kindling in rats.
Topics: Animals; Anticonvulsants; Antioxidants; Drug Therapy, Combination; Flavanones; Hippocampus; Kindling, Neurologic; Male; Oxidative Stress; Pentylenetetrazole; Phenytoin; Rats; Rats, Wistar; Seizures | 2018 |
The effect of co-administration of pentylenetetrazole with pilocarpine: New modified PTZ models of kindling and seizure.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Drug Resistance; Epilepsy; Kindling, Neurologic; Male; Miotics; Pentylenetetrazole; Phenytoin; Pilocarpine; Rats; Rats, Wistar; Seizures; Valproic Acid | 2019 |
Mild foot electrical stimulation is comparable with phenytoin in inhibiting pentylenetetrazol-induced kindling in rats.
Topics: Animals; Anticonvulsants; Electric Stimulation; Kindling, Neurologic; Male; Pentylenetetrazole; Phenytoin; Rats; Rats, Wistar | 2019 |
Exploring the ameliorative role of α7 neuronal nicotinic acetylcholine receptor modulation in epilepsy and associated comorbidities in post-PTZ-kindled mice.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anticonvulsants; Corticosterone; Depression; Dose-Response Relationship, Drug; Epilepsy; Kindling, Neurologic; Male; Memory Disorders; Mice; Pentylenetetrazole; Phenytoin; Valproic Acid | 2020 |
Pharmacodynamic and pharmacokinetic interactions of hydroalcoholic leaf extract of Centella asiatica with valproate and phenytoin in experimental models of epilepsy in rats.
Topics: Adjuvants, Pharmaceutic; Animals; Anticonvulsants; Behavior, Animal; Centella; Cognitive Dysfunction; Cytochrome P-450 Enzyme Inhibitors; Disease Models, Animal; Electroshock; Epilepsy; Glutathione; Herb-Drug Interactions; Malondialdehyde; Medicine, Ayurvedic; Methanol; Oxidative Stress; Pentylenetetrazole; Phenytoin; Plant Extracts; Plant Leaves; Rats, Wistar; Seizures; Valproic Acid | 2021 |
Gene Expression Analysis Identifies Cholesterol Metabolism Dysregulation in Hippocampus of Phenytoin-Resistant Pentylenetetrazol-Kindled Epileptic Mice.
Topics: Animals; Anticonvulsants; Cholesterol; Epilepsy; Gene Expression; Hippocampus; Humans; Kindling, Neurologic; Mice; Pentylenetetrazole; Phenytoin | 2021 |
Pyrrolopyridine and Isoindole as Potential Anticonvulsant Agents: Design, Synthesis, and Pharmacological Evaluation.
Topics: Amines; Anhydrides; Anticonvulsants; Electroshock; Humans; Isoindoles; Pentylenetetrazole; Phenytoin; Phthalimides; Pyridines; Seizures | 2022 |
Caffeine intoxication: Behavioral and electrocorticographic patterns in Wistar rats.
Topics: Animals; Anticonvulsants; Caffeine; Diazepam; Pentylenetetrazole; Phenobarbital; Phenytoin; Rats; Rats, Wistar; Seizures | 2022 |
In vitro and in vivo anti-seizure activity of hydromethanolic extract and fractions of Pterolobium stellatum.
Topics: Animals; Anticonvulsants; Butanols; Chloroform; Chromatography, Liquid; Diazepam; Ellagic Acid; Ethiopia; Kaempferols; Methanol; Mice; Mice, Inbred C57BL; Pentylenetetrazole; Phenytoin; Plant Extracts; Solvents; Tandem Mass Spectrometry; Water | 2023 |