phenytoin and omeprazole

phenytoin has been researched along with omeprazole in 36 studies

Research

Studies (36)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (5.56)	18.7374
1990's	10 (27.78)	18.2507
2000's	12 (33.33)	29.6817
2010's	10 (27.78)	24.3611
2020's	2 (5.56)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Afzelius, L; Andersson, TB; Baroni, M; Cruciani, G; Karlén, A; Masimirembwa, CM; Mecucci, S; Zamora, I	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Artursson, P; Bergström, CA; Draheim, R; Holmén, AG; Wassvik, CM	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M	1
Humphries, TJ	1
Andersson, T; Lagerström, PO; Unge, P	1
Kitchingman, GK; Langman, MJ; Prichard, PJ; Richens, A; Somerville, KW; Walt, RP; Williams, J	1
Gugler, R; Jensen, JC	1
Bliesath, H; Groenewoud, G; Huber, R; Hundt, HK; Middle, MV; Müller, FO; Schall, R; Steinijans, VW	2
Bachmann, KA; Jauregui, L; Levine, L; Miller, K; Reese, J; Sullivan, TJ	1
Bliesath, H; Hartmann, M; Huber, R; Radtke, HW; Steinijans, VW; Wurst, W; Zech, K	1
Hirata, M; Nishibe, Y	1
Amamoto, T; Higuchi, S; Ieiri, I; Irie, S; Kimura, M; Kubota, T; Mamiya, K; Nakamura, K; Nakano, S; Tashiro, N; Urae, A; Wada, Y; Yoshioka, S	1
Cavanaugh, JH; Karol, MD; Locke, CS	1
Giancarlo, GM; Granda, BW; Greenblatt, DJ; Venkatakrishnan, K; von Moltke, LL	1
Goldstein, JA	1
Bertino, JS; Nafziger, AN; Rogers, JF	1
Bachmann, KA; Jauregui, L; Levine, L; Miller, K; Reese, JH; Sullivan, TJ	1
Allgood, G; Allgood, L; Fendrick, AM; Grender, J; Peura, D; Schachtel, B; Shaw, M	1
Marks, B; Raucy, J; Trubetskoy, O; Yueh, MF; Zielinski, T	1
Fernández, FA; Garcés, FJ; Pintor, E; Quesada, R	1
Barr, M; Gabello, M; Mullin, JM; Valenzano, MC; Zurbach, P	1
Li, XY; Li, YP; Liu, YN; Yang, YZ; Yuan, M; Zhu, JB	1
Chinvarun, Y; Kijsanayotin, P; Limwongse, C; Rerkpattanapipat, T; Sukasem, C; Tempark, T; Yampayon, K	1
Agolini, E; Cecchetti, C; Cocciadiferro, D; Goffredo, BM; Marano, M; Nicoletti, F; Piervincenzi, E; Pro, S	1

Reviews

5 review(s) available for phenytoin and omeprazole

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Clinical implications of drug interactions with the cytochrome P-450 enzyme system associated with omeprazole. Digestive diseases and sciences, 1991, Volume: 36, Issue:12 Topics: Aminopyrine; Animals; Antipyrine; Cytochrome P-450 Enzyme System; Diazepam; Drug Interactions; Humans; Omeprazole; Phenytoin; Propranolol; Theophylline; Warfarin	1991
Lack of pantoprazole drug interactions in man. International journal of clinical pharmacology and therapeutics, 1994, Volume: 32, Issue:8 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Absorption; Antipyrine; Benzimidazoles; Contraceptives, Oral, Hormonal; Cross-Over Studies; Cytochrome P-450 Enzyme System; Diazepam; Digoxin; Drug Interactions; Female; Humans; Liver; Longitudinal Studies; Male; Nifedipine; Omeprazole; Pantoprazole; Phenytoin; Proton Pump Inhibitors; Sulfoxides; Theophylline; Tissue Distribution; Warfarin	1994
Clinical relevance of genetic polymorphisms in the human CYP2C subfamily. British journal of clinical pharmacology, 2001, Volume: 52, Issue:4 Topics: Alleles; Anti-Ulcer Agents; Anticonvulsants; Cytochrome P-450 Enzyme System; Humans; Mephenytoin; Omeprazole; Pharmaceutical Preparations; Phenytoin; Polymorphism, Genetic	2001
Pharmacogenetics affects dosing, efficacy, and toxicity of cytochrome P450-metabolized drugs. The American journal of medicine, 2002, Dec-15, Volume: 113, Issue:9 Topics: Anti-Arrhythmia Agents; Antidepressive Agents, Tricyclic; Aryl Hydrocarbon Hydroxylases; Codeine; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Diazepam; Genotype; Glipizide; Humans; Mixed Function Oxygenases; Omeprazole; Pharmacogenetics; Phenotype; Phenytoin; Warfarin	2002

Trials

6 trial(s) available for phenytoin and omeprazole

Article	Year
Oral phenytoin pharmacokinetics during omeprazole therapy. British journal of clinical pharmacology, 1987, Volume: 24, Issue:4 Topics: Administration, Oral; Adult; Drug Interactions; Half-Life; Humans; Male; Omeprazole; Phenytoin	1987
No influence of pantoprazole on the pharmacokinetics of phenytoin. International journal of clinical pharmacology and therapeutics, 1995, Volume: 33, Issue:5 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Absorption; Administration, Oral; Adolescent; Adult; Benzimidazoles; Biological Availability; Chromatography, High Pressure Liquid; Cross-Over Studies; Double-Blind Method; Drug Interactions; Humans; Male; Omeprazole; Pantoprazole; Phenytoin; Proton Pump Inhibitors; Reference Standards; Sulfoxides; White People	1995
Lack of pantoprazole drug interactions in man. International journal of clinical pharmacology and therapeutics, 1994, Volume: 32, Issue:8 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Absorption; Antipyrine; Benzimidazoles; Contraceptives, Oral, Hormonal; Cross-Over Studies; Cytochrome P-450 Enzyme System; Diazepam; Digoxin; Drug Interactions; Female; Humans; Liver; Longitudinal Studies; Male; Nifedipine; Omeprazole; Pantoprazole; Phenytoin; Proton Pump Inhibitors; Sulfoxides; Theophylline; Tissue Distribution; Warfarin	1994
No influence of pantoprazole on the pharmacokinetics of phenytoin. International journal of clinical pharmacology and therapeutics, 1996, Volume: 34, Issue:1 Suppl Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adolescent; Adult; Anticonvulsants; Area Under Curve; Benzimidazoles; Cross-Over Studies; Double-Blind Method; Drug Interactions; Enzyme Inhibitors; Half-Life; Humans; Male; Omeprazole; Pantoprazole; Phenytoin; Proton Pump Inhibitors; Sulfoxides	1996
Stereoselective 4'-hydroxylation of phenytoin: relationship to (S)-mephenytoin polymorphism in Japanese. British journal of clinical pharmacology, 1997, Volume: 43, Issue:4 Topics: Administration, Oral; Alleles; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Gene Expression Regulation, Enzymologic; Genotype; Homozygote; Humans; Hydroxylation; Japan; Mixed Function Oxygenases; Omeprazole; Phenotype; Phenytoin; Polymerase Chain Reaction; Polymorphism, Genetic; Stereoisomerism; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases	1997
Lack of pharmacokinetic interaction between lansoprazole and intravenously administered phenytoin. Journal of clinical pharmacology, 1999, Volume: 39, Issue:12 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Anti-Ulcer Agents; Anticonvulsants; Cross-Over Studies; Cytochrome P-450 Enzyme System; Double-Blind Method; Drug Interactions; Humans; Injections, Intravenous; Lansoprazole; Male; Metabolic Clearance Rate; Omeprazole; Phenytoin	1999

Other Studies

26 other study(ies) available for phenytoin and omeprazole

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Conformer- and alignment-independent model for predicting structurally diverse competitive CYP2C9 inhibitors. Journal of medicinal chemistry, 2004, Feb-12, Volume: 47, Issue:4 Topics: Amino Acids; Aryl Hydrocarbon Hydroxylases; Binding Sites; Cytochrome P-450 CYP2C9; Enzyme Inhibitors; Models, Molecular; Molecular Conformation; Molecular Structure; Quantitative Structure-Activity Relationship	2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Molecular characteristics for solid-state limited solubility. Journal of medicinal chemistry, 2008, May-22, Volume: 51, Issue:10 Topics: Chemical Phenomena; Chemistry, Physical; Molecular Structure; Multivariate Analysis; Pharmaceutical Preparations; Regression Analysis; Solubility	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology. Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3 Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries	2023
A study of the interaction between omeprazole and phenytoin in epileptic patients. Therapeutic drug monitoring, 1990, Volume: 12, Issue:4 Topics: Adult; Drug Interactions; Epilepsy; Female; Humans; Male; Middle Aged; Omeprazole; Phenytoin; Time Factors	1990
Omeprazole inhibits oxidative drug metabolism. Studies with diazepam and phenytoin in vivo and 7-ethoxycoumarin in vitro. Gastroenterology, 1985, Volume: 89, Issue:6 Topics: Adult; Benzimidazoles; Coumarins; Diazepam; Drug Interactions; Humans; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Nordazepam; Omeprazole; Oxidation-Reduction; Phenytoin	1985
Drug interactions of H2-receptor antagonists. Scandinavian journal of gastroenterology. Supplement, 1994, Volume: 206 Topics: Adolescent; Adult; Aged; Antacids; Biological Availability; Cimetidine; Drug Interactions; Famotidine; Histamine H2 Antagonists; Humans; Middle Aged; Nizatidine; Omeprazole; Phenytoin; Ranitidine; Theophylline	1994
Induction of cytochrome P450 3A (CYP 3A) by E 5110, a non-steroidal anti-inflammatory agent (NSAID), and typical CYP 3A inducers in primary cultures of dog hepatocytes. Biological & pharmaceutical bulletin, 1995, Volume: 18, Issue:8 Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbamazepine; Cells, Cultured; Clofibrate; Clotrimazole; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Dogs; Drug Interactions; Enzyme Induction; Liver; Male; Mixed Function Oxygenases; Omeprazole; Phenobarbital; Phenytoin; Pyrrolidinones; Rifampin; Steroid Hydroxylases	1995
Relative contributions of CYP2C9 and 2C19 to phenytoin 4-hydroxylation in vitro: inhibition by sulfaphenazole, omeprazole, and ticlopidine. European journal of clinical pharmacology, 2001, Volume: 57, Issue:1 Topics: Anti-Infective Agents; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Fibrinolytic Agents; Humans; Hydroxylation; Microsomes, Liver; Mixed Function Oxygenases; Omeprazole; Phenytoin; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Sulfaphenazole; Ticlopidine	2001
Absence of an inhibitory effect of omeprazole and nizatidine on phenytoin disposition, a marker of CYP2C activity. British journal of clinical pharmacology, 1993, Volume: 36, Issue:4 Topics: Adult; Analysis of Variance; Anti-Ulcer Agents; Anticonvulsants; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Male; Nizatidine; Omeprazole; Phenytoin	1993
Self-selection and use patterns of over-the-counter omeprazole for frequent heartburn. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2004, Volume: 2, Issue:1 Topics: Adolescent; Adult; Anti-Ulcer Agents; Anticonvulsants; Consumer Product Safety; Drug Labeling; Female; Follow-Up Studies; Heartburn; Humans; Interviews as Topic; Male; Middle Aged; Nonprescription Drugs; Omeprazole; Patient Compliance; Phenytoin; Proton Pump Inhibitors; Proton Pumps; Recurrence; Referral and Consultation; Self Medication; Time Factors; United States	2004
A simultaneous assessment of CYP3A4 metabolism and induction in the DPX-2 cell line. The AAPS journal, 2005, Mar-04, Volume: 7, Issue:1 Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Chromans; Clotrimazole; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Dimethyl Sulfoxide; Enhancer Elements, Genetic; Enzyme Induction; Genes, Reporter; Genes, Synthetic; Humans; Ketoconazole; Liver Neoplasms; Lovastatin; Luciferases; Mifepristone; Neoplasm Proteins; Nifedipine; Omeprazole; Paclitaxel; Phenytoin; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Recombinant Fusion Proteins; Rifampin; Thiazolidinediones; Transcription, Genetic; Troglitazone; Troleandomycin	2005
[Toxic epidermal necrolysis induced by phenytoin and whole brain radiotherapy]. Actas dermo-sifiliograficas, 2007, Volume: 98, Issue:7 Topics: Adenocarcinoma; Aged; Anticonvulsants; Brain Neoplasms; Breast Neoplasms; Combined Modality Therapy; Cranial Irradiation; Dexamethasone; Drug Therapy, Combination; Epilepsy; Female; Humans; Mastectomy, Radical; Omeprazole; Phenytoin; Stevens-Johnson Syndrome	2007
Omeprazole induces gastric permeability to digoxin. Digestive diseases and sciences, 2010, Volume: 55, Issue:5 Topics: Animals; Chromatography, Thin Layer; Digoxin; Electrophysiology; Gastric Mucosa; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Omeprazole; Permeability; Phenytoin; Proton Pump Inhibitors; Rats; Rats, Sprague-Dawley; Tight Junctions	2010
[Effect of high altitude hypoxia on the activity and protein expression of CYP2C9 and CYP2C19]. Yao xue xue bao = Acta pharmaceutica Sinica, 2012, Volume: 47, Issue:2 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Administration, Oral; Altitude; Animals; Cytochrome P-450 Enzyme System; Enzyme Activation; Female; Hypoxia; Male; Omeprazole; Phenytoin; Rats; Rats, Sprague-Dawley	2012
Influence of genetic and non-genetic factors on phenytoin-induced severe cutaneous adverse drug reactions. European journal of clinical pharmacology, 2017, Volume: 73, Issue:7 Topics: Adult; Aged; Anti-Ulcer Agents; Anticonvulsants; Asian People; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Drug Eruptions; Female; Genotype; HLA-B Antigens; Humans; Male; Middle Aged; Odds Ratio; Omeprazole; Phenytoin; Proton Pump Inhibitors	2017
Phenytoin intoxication associated with omeprazole administration in a child with defective CYP2C9. European journal of clinical pharmacology, 2020, Volume: 76, Issue:5 Topics: Child, Preschool; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Drug Interactions; Genotype; Humans; Omeprazole; Phenytoin; Polymorphism, Genetic	2020