phenytoin and methimazole

phenytoin has been researched along with methimazole in 15 studies

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19907 (46.67)18.7374
1990's0 (0.00)18.2507
2000's3 (20.00)29.6817
2010's5 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Andricopulo, AD; Moda, TL; Montanari, CA1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Aizawa, T; Kawabe, T; Tsukui, T; Yamada, T1
Bechar, M; Korczyn, AD1
Dalton, C; Verebely, K1
Pedersen, KO1
Nicoloff, JT1
Madappally, MW; Mehlman, MA; Ruegamer, WR; Tobin, RB1
Zaninovich, AA1

Reviews

1 review(s) available for phenytoin and methimazole

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

1 trial(s) available for phenytoin and methimazole

ArticleYear
Effects of oestrogens on thyroxine turnover in hyperthyroidism.
    Acta endocrinologica, 1972, Volume: 71, Issue:3

    Topics: Adult; Estrogens; Female; Graves Disease; Humans; Hyperthyroidism; Injections, Intravenous; Iodine Isotopes; Male; Methimazole; Middle Aged; Phenols; Phenytoin; Placebos; Thyroid Gland; Thyroxine; Thyroxine-Binding Proteins

1972

Other Studies

13 other study(ies) available for phenytoin and methimazole

ArticleYear
Hologram QSAR model for the prediction of human oral bioavailability.
    Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24

    Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2007
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
Studies on the mechanism of goitrogenic action of diphenylthiohydantoin.
    Endocrinology, 1978, Volume: 102, Issue:6

    Topics: Animals; Antithyroid Agents; Iodine; Male; Methimazole; Organ Size; Phenytoin; Propylthiouracil; Rats; Thyroid Gland; Thyroxine; Triiodothyronine

1978
Convulsive fits in thyrotoxicosis.
    Epilepsia, 1976, Volume: 17, Issue:1

    Topics: Adult; Humans; Hyperthyroidism; Male; Methimazole; Phenytoin; Seizures

1976
Hypotriglyceridemic activity of 5,5'-diphenyl-2-thiohydantoin (DPTH).
    The Journal of pharmacology and experimental therapeutics, 1972, Volume: 180, Issue:2

    Topics: Animals; Antithyroid Agents; Lipids; Liver; Male; Methimazole; Methylthiouracil; Organ Size; Phenytoin; Phospholipids; Propylthiouracil; Rats; Rats, Inbred Strains; Thiouracil; Thyroid Gland; Triglycerides

1972
A systematic study of variables affecting protein binding of thyroxine and triiodothyronine in serum.
    Scandinavian journal of clinical and laboratory investigation, 1974, Volume: 34, Issue:3

    Topics: Anions; Barbiturates; Buffers; Caffeine; Depression, Chemical; Dialysis; Humans; Hydrogen-Ion Concentration; Iodine Radioisotopes; Methimazole; Osmolar Concentration; Phenytoin; Protein Binding; Salicylates; Temperature; Theophylline; Thyroxine; Thyroxine-Binding Proteins; Time Factors; Triiodothyronine; Ultrafiltration

1974
A new method for the measurement of acute alterations in thyroxine deiodination rate in man.
    The Journal of clinical investigation, 1970, Volume: 49, Issue:2

    Topics: Adrenocorticotropic Hormone; Epinephrine; Humans; Hydrocortisone; Iodine; Iodine Radioisotopes; Methimazole; Methods; Oxytocin; Phenytoin; Potassium Iodide; Prednisolone; Propylthiouracil; Thyrotropin; Thyroxine; Triiodothyronine

1970
Mode of action of 5,5'-diphenylthiohydantoin-sites of action of 5,5'-diphenylthiohydantoin in mitochondria in relationship to thyroxine-stimulated responses.
    Biochemical pharmacology, 1972, Aug-01, Volume: 21, Issue:15

    Topics: Animals; Binding Sites; Carbon Isotopes; Carboxy-Lyases; Carnitine; Diet; Dinitrophenols; Drug Interactions; Fructose-Bisphosphatase; Gluconeogenesis; Glucose-6-Phosphatase; Glycerophosphates; In Vitro Techniques; Ligases; Liver; Methimazole; Mitochondria, Liver; Oxygen Consumption; Phenytoin; Pyruvates; Rats; Succinates; Sulfides; Thyroxine

1972