phenytoin has been researched along with hexobarbital in 39 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (84.62) | 18.7374 |
| 1990's | 1 (2.56) | 18.2507 |
| 2000's | 4 (10.26) | 29.6817 |
| 2010's | 1 (2.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Caron, G; Ermondi, G | 1 |
| Abraham, MH; Acree, WE; Ibrahim, A | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Brodeur, J; Côte, MG; Gascon-Barré, M | 1 |
| Karasawa, T; Masuda, Y; Shimizu, M; Shiraishi, Y; Utsui, Y; Yoshida, K | 1 |
| Franklin, MR; James, RC | 1 |
| Carrer, H; Meyerson, BJ | 1 |
| Bhattacharya, SK; Ghosal, S; Reddy, PK; Sharma, PV; Singh, AK | 1 |
| Latham, AN; Sweeney, GD | 1 |
| Breyer, U; Villumsen, D | 1 |
| Becker, BA; Gut, I | 1 |
| Gerber, N; Hilliard, JB; Mays, DC; Nawoot, S; Pacula, CM | 1 |
| Hanano, M; Harashima, H; Iga, T; Sawada, Y; Sugiyama, Y | 1 |
| McClain, RM; Rohrs, JM | 1 |
| Estabrook, RW; Greim, H; Remmer, H; Schenkman, J | 1 |
| Greengard, P; Quinn, GP; Reid, MB | 1 |
| Arnold, K; Gerber, N | 2 |
| Mandel, HG; Riis, M | 1 |
| Falk, M; Fürst, W | 1 |
| Cely, W; Karler, R; Turkanis, SA | 1 |
| Brückner, UB; Deuster, JE; Hoyer, S; Mast, GJ; Mittmann, U; Schmidt, HD; Schmier, J; van Ackern, K | 1 |
| Bacci, MC; Bianchi, C; Bonardi, G; Coppi, G; Molino, C; Tomasi, L; Vidi, A | 1 |
| Kostenbauder, HB; Lubawy, WC; Stavchansky, SA | 1 |
| Nebert, DW; Robinson, JR | 1 |
| Bartl, P; Dalton, C; Kamm, JJ | 1 |
| Remmer, H | 1 |
| Kemp, JW; Swinyard, EA; Tannhauser, M | 1 |
| Becker, BA; Eling, TE; Fouts, JR; Harbison, RD | 1 |
| Fukuda, T; Katsuda, N; Tanaka, K | 1 |
| Krimsley, V; Shaffer, JW; Steinberg, E; Winstead, WB | 1 |
| Costa, E; Groppetti, A | 1 |
| Noordhoek, J; Rümke, CL | 1 |
| Ilczuk, I; Rabsztyn, T; Rump, S; Walczyna, K | 1 |
| Breimer, DD; Richter, E; Zilly, W | 1 |
| Gelboin, HV; Kim, ND; Park, SS; Won, SM; Yoo, JK | 1 |
| Afshari, CA; Barrett, JC; Bennett, L; Blanchard, K; Bushel, PR; DiSorbo, O; Hamadeh, HK; Jayadev, S; Li, L; Paules, RS; Stoll, R; Tennant, R | 1 |
| BURNS, JJ | 1 |
1 review(s) available for phenytoin and hexobarbital
| Article | Year |
|---|---|
IMPLICATIONS ON ENZYME INDUCTION FOR DRUG THERAPY.
Topics: Animals; Benzopyrenes; Cyclizine; Dicumarol; Diphenhydramine; Dogs; Drug Therapy; Enzyme Induction; Enzymes; Glutethimide; Hexobarbital; Liver; Meprobamate; Metabolism; Pharmacology; Phenobarbital; Phenylbutazone; Phenytoin; Probenecid; Rats; Research; Tolbutamide; Toxicology; Zoxazolamine | 1964 |
38 other study(ies) available for phenytoin and hexobarbital
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs.
Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Hepatic drug metabolism after phenobarbital and diphenylhydantoin administration in the rat--influence of vitamin D3 status.
Topics: Animals; Calcium; Cholecalciferol; Hexobarbital; Liver; Male; Mixed Function Oxygenases; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Phosphorus; Rats; Sleep; Time Factors; Vitamin D Deficiency | 1979 |
Pharmacokinetic and pharmacodynamic tolerance of a new anticonvulsant agent (3-sulfamoylmethyl-1,2-benzisoxazole) compared to phenobarbital, diphenylhydantoin and carbamazepine in rats.
Topics: Animals; Anticonvulsants; Carbamazepine; Drug Interactions; Hexobarbital; Isoxazoles; Kinetics; Male; Oxazoles; Phenobarbital; Phenytoin; Proadifen; Rats; Sleep; Time Factors | 1979 |
The triphasic amphetamine lethal dose curve in mice and its possible relationship to drug metabolism.
Topics: Aging; Amphetamine; Animals; Anticonvulsants; Dextroamphetamine; Hexobarbital; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Microsomes, Liver; Phenytoin; Piperonyl Butoxide; Proadifen; Sleep | 1978 |
Effect of CNS depressants and stimulants on latency for the appearance of copulatory response in the female rat.
Topics: 20-alpha-Dihydroprogesterone; Adrenal Glands; Animals; Copulation; Estradiol; Ether; Female; Hexobarbital; Ovary; Phenytoin; Picrotoxin; Rats; Strychnine; Time Factors | 1976 |
Chemical constituents of Gentianaceae XIX: CNS-depressant effects of swertiamarin.
Topics: Amphetamine; Animals; Anticonvulsants; Behavior, Animal; Central Nervous System; Depression, Chemical; Drug Interactions; Glucosides; Glycosides; Hexobarbital; Iridoid Glucosides; Mice; Morphine; Motor Skills; Phenytoin; Plant Extracts; Plants, Medicinal; Pyrans; Pyrones; Rats; Sleep; Xanthenes; Xanthones | 1976 |
Binding of anticonvulsant drugs to cytochrome P-450: correlation with evidence of induction of hepatic microsomal enzymes.
Topics: Animals; Anticonvulsants; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Glucaric Acid; Hexobarbital; In Vitro Techniques; Kinetics; Male; Mephenytoin; Microsomes, Liver; Phenobarbital; Phenylbutyrates; Phenytoin; Rats; Receptors, Drug; Urea | 1976 |
Thin-layer chromatographic determination of barbiturates and phenytoin in serum and blood.
Topics: Animals; Barbiturates; Chromatography, Thin Layer; Dose-Response Relationship, Drug; Hexobarbital; Humans; Kinetics; Phenobarbital; Phenytoin; Rats | 1975 |
Diphenylhydantoin effects on hexobarbital and aniline biotransformation in male rats: differences between in vitro and in vivo observations.
Topics: Aniline Compounds; Animals; Biotransformation; Body Weight; Hexobarbital; In Vitro Techniques; Liver; Male; Microsomes, Liver; Organ Size; Phenytoin; Rats; Time Factors | 1975 |
Inhibition and induction of drug biotransformation in vivo by 8-methoxypsoralen: studies of caffeine, phenytoin and hexobarbital metabolism in the rat.
Topics: Animals; Biotransformation; Caffeine; Hexobarbital; Male; Methoxsalen; Phenytoin; Rats; Rats, Inbred Strains | 1987 |
Prediction of serum concentration time course of quinidine in human using a physiologically based pharmacokinetic model developed from the rat.
Topics: Animals; Antipyrine; Half-Life; Hexobarbital; Humans; Kidney; Kinetics; Liver; Metabolic Clearance Rate; Models, Biological; Phenytoin; Quinidine; Rats; Time Factors | 1986 |
Potentiation of the teratogenic effects and altered disposition of diphenylhydantoin in mice fed a purified diet.
Topics: Analysis of Variance; Animals; Cleft Palate; Congenital Abnormalities; Diet; Female; Fetus; Hexobarbital; Mice; Phenytoin; Pregnancy; Sleep | 1985 |
Reaction of drugs with microsomal liver hydroxylase: its influence on drug action.
Topics: Aniline Compounds; Animals; Antipyrine; Benzopyrenes; Cytochromes; Dicumarol; Electron Transport; Enzyme Induction; Hexobarbital; Kinetics; Liver; Methylcholanthrene; Microsomes; Mixed Function Oxygenases; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Protein Binding; Prothrombin Time | 1968 |
Prevention by antidepressant drugs of reserpine effect on pyridine nucleotide metabolism.
Topics: Aminopyrine; Amitriptyline; Amphetamine; Animals; Antidepressive Agents; Atropine; Benactyzine; Caffeine; Chlorpheniramine; Chlorpromazine; Female; Hexobarbital; Hydralazine; Hypothalamus; Imipramine; Iproniazid; Isoniazid; Liver; Meprobamate; Methacholine Compounds; Morphine; NAD; Niacinamide; Pargyline; Pentobarbital; Phenylbutazone; Phenytoin; Quinacrine; Rats; Reserpine; Tranylcypromine; Tripelennamine; Zoxazolamine | 1966 |
The effect of diphenyl-piperazine compounds and other agents on diphenylhydantoin, zoxazolamine and hexobarbital metabolism.
Topics: Animals; Benzopyrenes; Cyclizine; DDT; Diphenhydramine; Endoplasmic Reticulum; Hexobarbital; Humans; Hydroxyzine; Liver; Male; Meclizine; Methylcholanthrene; Mice; Microscopy, Electron; Phenethylamines; Phenobarbital; Phenytoin; Piperazines; Trifluoperazine; Zoxazolamine | 1968 |
Interference of barbiturates with pyrimidine incorporation. II. Structural specificity of the inhibition of orotate uptake in Bacillus cereus.
Topics: Amobarbital; Bacillus cereus; Barbiturates; Bemegride; Biological Transport; Carbon Isotopes; Carboxylic Acids; Central Nervous System Stimulants; Chemical Phenomena; Chemistry; Chemistry, Physical; Chlorine; Chlorpromazine; Glutethimide; Hexobarbital; Hydantoins; Hydrocarbons, Halogenated; Hydrogen-Ion Concentration; Orotic Acid; Pentobarbital; Phenobarbital; Phenytoin; Primidone; Solubility; Succinimides; Thiopental; Thymine; Trimethadione; Tromethamine; Uracil; Urea | 1970 |
[Drug permeation through synthetic lipid membranes. Permeability of lecithin-collodium membranes for drugs and metabolites].
Topics: Buffers; Caffeine; Diffusion; Hexobarbital; Hydrogen-Ion Concentration; Kinetics; Membranes, Artificial; Models, Chemical; Papaverine; Phenobarbital; Phenytoin; Phosphatidylcholines; Quinine; Salicylates; Solutions; Time Factors | 1974 |
A study of the development of tolerance to an anticonvulsant effect of delta9-tetrahydrocannabinol and cannabidiol.
Topics: Animals; Anticonvulsants; Cannabis; Dronabinol; Drug Interactions; Drug Synergism; Drug Tolerance; Electroshock; Hexobarbital; Male; Mice; Mice, Inbred ICR; Phenobarbital; Phenytoin; Resorcinols; Sleep; Terpenes; Time Factors | 1974 |
[Negative inotropic effects of hexobarbital, diphenylhydantoin, propanidid and chlormethiazole on the previously damaged heart (author's transl)].
Topics: Animals; Child; Chlormethiazole; Depression, Chemical; Dogs; Female; Heart; Hemodynamics; Hexobarbital; Humans; Male; Middle Aged; Phenytoin; Propanidid | 1973 |
Experimental models for the in vivo evaluation of enzyme induction properties of drugs.
Topics: Acetanilides; Amides; Aminopyrine; Amphetamine; Aniline Compounds; Animals; Central Nervous System; Codeine; Cyclohexanecarboxylic Acids; Drug Evaluation, Preclinical; Enzyme Activation; Enzyme Induction; Hexobarbital; Male; Meperidine; Mice; Oxotremorine; Pentobarbital; Phenacetin; Phenytoin; Rabbits; Rats; Strychnine; Tolbutamide; Tremorine; Zoxazolamine | 1973 |
Increase of hexobarbital sleeping time and inhibition of drug metabolism by the major metabolite of diphenylhydantoin.
Topics: Animals; Drug Interactions; Hexobarbital; Liver; Male; Morphinans; Phenytoin; Rats; Sleep; Time Factors | 1974 |
Genetic expression of aryl hydrocarbon hydroxylase induction. Presence or absence of association with zoxazolamine, diphenylhydantoin, and hexobarbital metabolism.
Topics: Animals; Benzopyrenes; Carbon Radioisotopes; Crosses, Genetic; Flavonoids; Hexobarbital; Hydrocarbons; Liver; Methylcholanthrene; Mice; Mice, Inbred AKR; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Mixed Function Oxygenases; Molecular Biology; Phenytoin; Sleep; Time Factors; Zoxazolamine | 1974 |
5,5'-Diphenyl-2-thiohydantoin (DPTH): an inducer of microsomal drug-metabolizing enzymes.
Topics: Animals; Cytochromes; Electron Transport; Endoplasmic Reticulum; Enzyme Induction; Hexobarbital; Liver; Male; Mice; Mice, Inbred Strains; Microscopy, Electron; Microsomes, Liver; Organ Size; Phenobarbital; Phenytoin; Proteins; Rats; Rats, Inbred Strains; Sleep; Sulfides; Time Factors | 1972 |
[Changes of drug effects caused by their metabolism in the liver].
Topics: Aminopyrine; Animals; Cytochromes; Dogs; Drug Stability; Endoplasmic Reticulum; Female; Fetus; Hexobarbital; Humans; Liver; Male; Metabolism; Mice; Pentobarbital; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Pregnancy; Rabbits; Rats; Thiopental | 1971 |
Effect of diphenylhydantoin on hexobarbital sleep time in mice and rats.
Topics: Animals; Depression, Chemical; Hexobarbital; In Vitro Techniques; Male; Mice; Microsomes, Liver; Nervous System; Phenytoin; Rats; Sleep; Time Factors | 1971 |
Diphenylhydantoin effect on neonatal and adult rat hepatic drug metabolism.
Topics: Age Factors; Aminopyrine; Aniline Compounds; Animals; Animals, Newborn; Benzoates; Benzopyrenes; Benzphetamine; Body Weight; Cytochromes; Hexobarbital; Hydrogen-Ion Concentration; In Vitro Techniques; Liver; Microsomes, Liver; Mixed Function Oxygenases; Nitrophenols; Organ Size; Phenytoin; Proteins; Rats | 1970 |
Discharge patterns of single reticular neuron synchronized with electrocortical spike induced by pentetrazol.
Topics: Animals; Electroencephalography; Female; Hexobarbital; Injections, Intravenous; Lidocaine; Male; Neurons; Pentylenetetrazole; Phenytoin; Rats; Reticular Formation | 1970 |
Substitution in the hydantoin ring. VII. N-3-Propionic acid and its ethyl ester and N-3-(2-cyanoethyl) derivatives.
Topics: Alkylation; Animals; Drug Synergism; Electroshock; Hexobarbital; Hydantoins; Infrared Rays; Magnetic Resonance Spectroscopy; Male; Mice; Motor Activity; Pentylenetetrazole; Phenytoin; Propionates; Spectrum Analysis; Ultraviolet Rays | 1968 |
Studies on the metabolism of diphenylhydantoin in mice.
Topics: Animals; Cycloheximide; Cytochromes; Hexobarbital; Hydroxyzine; Kinetics; Liver; Male; Mice; Microsomes; Organ Size; Paralysis; Phenytoin; Proadifen; Sleep; Zoxazolamine | 1969 |
Factors affecting the rate of disappearance of amphetamine in rats.
Topics: Age Factors; Animals; Dextroamphetamine; Estradiol; Female; Hexobarbital; Liver; Male; Methylcholanthrene; Microsomes; Mixed Function Oxygenases; Phenobarbital; Phenytoin; Rats; Sex Factors; Time Factors; Zoxazolamine | 1969 |
The influence of lynestrenol on the rate of metabolism of phenobarbital, phenytoin and hexobarbital in mice.
Topics: Animals; Bemegride; Electroshock; Enzyme Induction; Female; Hexobarbital; Lynestrenol; Male; Mice; Phenobarbital; Phenytoin; Seizures; Sleep; Time Factors | 1969 |
Pharmacological properties of N-aminodiphenylhydantoin, a new hydantoin derivative with anticonvulsant activity.
Topics: Animals; Anticonvulsants; Drug Interactions; Electroshock; Female; Hexobarbital; Lethal Dose 50; Mice; Motor Activity; Phenytoin; Sleep | 1981 |
Disposition of hexobarbital in intra- and extrahepatic cholestasis in man and the influence of drug metabolism-inducing agents.
Topics: Adult; Aged; Cholestasis, Extrahepatic; Cholestasis, Intrahepatic; Enzyme Induction; Female; Hexobarbital; Humans; Inactivation, Metabolic; Kinetics; Liver; Male; Metabolic Clearance Rate; Middle Aged; Phenobarbital; Phenytoin; Rifampin | 1980 |
Phenytoin induction of cytochrome P4502B in mice: effects on hexobarbital hydroxylase activity.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Hexobarbital; Immunochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenytoin; Sleep | 1993 |
Prediction of compound signature using high density gene expression profiling.
Topics: Algorithms; Animals; Computational Biology; Databases, Factual; Diethylhexyl Phthalate; Discriminant Analysis; DNA, Complementary; Dose-Response Relationship, Drug; Gene Expression Profiling; Genomics; Hexobarbital; Liver; Male; Oligonucleotide Array Sequence Analysis; Pattern Recognition, Automated; Phenytoin; Predictive Value of Tests; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Reference Standards; RNA, Messenger; Single-Blind Method; Structure-Activity Relationship; Xenobiotics | 2002 |