phenytoin has been researched along with fosphenytoin in 238 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (3.36) | 18.7374 |
| 1990's | 72 (30.25) | 18.2507 |
| 2000's | 60 (25.21) | 29.6817 |
| 2010's | 65 (27.31) | 24.3611 |
| 2020's | 33 (13.87) | 2.80 |
| Authors | Studies |
|---|---|
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Brouwer, KL; Donn, KH; Dukes, GE; Hak, LJ; Hussey, EK; Krol, TF; Messenheimer, JA | 1 |
| Boucher, BA; Graves, NM; Leppik, IE; Murthy, VS; Rangel, RJ; Rask, CA; Turlapaty, P; Watridge, C; Wilder, BJ | 1 |
| Treiman, DM; Walton, NY | 1 |
| Achari, R; Bombassaro, AM; Boucher, BA; Rasmussen, SN; Turlapaty, P; Watridge, CB | 1 |
| Boucher, R; Graves, NM; Leppik, IE; Murthy, VS; Rangel, RJ; Rask, CA; Turlapaty, P; Watridge, C; Wilder, BJ | 1 |
| Browne, TR; Davoudi, H; Donn, KH; Dougherty, CL; Dukes, GE; Evans, B; Evans, JE; Jamerson, B; Kres, J; McEntegart, CM | 1 |
| Brown, BS; Maher, RW; Matier, WL; Smith, RD | 1 |
| Uthman, BM; Wilder, BJ | 1 |
| Donn, KH; Gerber, N; Guthrie, RM; Laddu, A; Mays, DC; Quon, CY; Rivenburg, WK; Turlapaty, P | 1 |
| Stella, VJ; Varia, SA | 2 |
| Bebin, M; Bleck, TP | 1 |
| Lai, CM; Moore, P; Quon, CY | 1 |
| Browne, TR; Davoudi, H; Dougherty, CL; Evans, BA; Evans, JE; Kres, J; McEntegart, C; Miceli, JJ; Quon, C; Szabo, GK | 1 |
| Stewart, BH; TenHoor, CN | 1 |
| Wilder, BJ | 1 |
| Pellock, JM | 1 |
| DeToledo, J; Ramsay, RE | 1 |
| Allen, FH; Runge, JW | 1 |
| Ramsay, RE; Uthman, BM; Wilder, BJ | 1 |
| Browne, TR; Eldon, MA; Kugler, AR | 1 |
| Campbell, K; Garnett, WR; Henkin, SA; Kugler, AR; Pellock, JM; Ramsay, RE; Wilder, BJ | 1 |
| Paloucek, FP | 2 |
| Benezra, DA; Fierro, LS; Savulich, DH | 1 |
| Bradbury-Golas, K; Carson, L | 1 |
| Browne, TR | 1 |
| Matheson, C | 1 |
| Collette, DR; Cramer, RL | 1 |
| Orr, J | 1 |
| Hopefl, A | 1 |
| Guanci, R; Lilley, LL | 1 |
| Morton, LD; Pellock, JM; Rizkallah, E | 1 |
| Cwik, MJ; Deyo, KL; Fischer, JH; Luer, MS; Sibley, CB | 1 |
| Miller, MH | 1 |
| Andrews, C; Cwik, MJ; Deyo, K; Fischer, J; Liang, M | 1 |
| Roberge, RJ | 1 |
| Vossler, DG; Wyler, AR | 1 |
| Kendall, JD | 1 |
| Cantu, TG | 1 |
| Barkley, GL; Garnett, WR; Knapp, LE; Leppik, IE; Pellock, JM; Ramsay, RE; Uthman, BM; Wilder, BJ | 1 |
| Fierro, L; Hudak, J | 1 |
| Marble, EL | 1 |
| Curry, WJ; Kulling, DL | 1 |
| Bazil, CW; Pedley, TA | 1 |
| Dasgupta, A; Datta, P | 1 |
| Luer, MS | 1 |
| Pruitt, AC | 1 |
| Comes, J | 1 |
| Ebert, U; Löscher, W; Reissmüller, E | 3 |
| Lowenstein, DH | 1 |
| Luer, MS; Winkler, SR | 1 |
| Fiechtner, HB | 1 |
| Churchill, JD; Garraghty, PE; Miller, DP; Steinmetz, JE; Voss, SE | 1 |
| Annesley, TM; Koup, JR; Kugler, AR; Nordblom, GD; Olson, SC | 1 |
| Narisawa, S; Stella, VJ | 1 |
| Wheless, JW | 2 |
| Knapp, LE; Kugler, AR | 1 |
| Morton, LD | 1 |
| Graves, N | 1 |
| Birnbaum, AK; Nelson, MH; Nyhus, PJ; Remmel, RP | 1 |
| Caviness, VS; Krishnamoorthy, KS; Soman, TB; Takeoka, M | 1 |
| Dasgupta, A; Havlik, D | 1 |
| El Yafi, K; Kim, JM; Treiman, DM; Uthman, BM; Walton, NY | 1 |
| Graziano, MJ; Krishna, G; Kropko, ML; Manca, D; Walker, RM | 1 |
| Nightingale, SL | 1 |
| Hutt, N | 1 |
| Dasgupta, A; Datta, P; Warner, BF | 1 |
| Brown, J | 1 |
| Burstein, AH; Cox, DS; Eddington, ND; Mistry, B | 1 |
| Benfield, P; Holliday, SM; Plosker, GL | 1 |
| Annesley, TM; Coleman, JP; De, BK; Roberts, WL | 1 |
| Alldredge, BK; Aweeka, FT; Boyer, TD; Eldon, MA; Gambertoglio, JG; Gottwald, MD; Kugler, AR; Pollock, AS; Wright, TL | 1 |
| Chan, SA; Iyer, V; Miller, JJ; Reid, KH; Schurr, A; Tseng, MT | 1 |
| Armstrong, EP; Downey, MJ; Sauer, KA | 1 |
| Bleck, TP | 1 |
| Chioffi, SM; Lassiter, TF; McLendon, BM; Scates, AC | 1 |
| Dasgupta, A; Datta, P; Handy, BC | 1 |
| Heafield, MT | 1 |
| DeToledo, JC; Ramsay, RE | 1 |
| Burstein, AH; Evans, JL; Roby, CA | 1 |
| Rhoney, DH; Touchette, DR | 1 |
| Jagoda, A; Yoon, Y | 1 |
| Bouget, J; Principe, A | 1 |
| DeToledo, J; Gidal, B; Morgan, RO; Pryor, FM; Ramsay, RE | 1 |
| DeToledo, JC; Lowe, MR; Rabinstein, A; Villaviza, N | 1 |
| Bruder, N; Gouin, F; Pollet, L; Presutti, M; Stordeur, JM | 1 |
| Cifuentes, RF; Kriel, RL | 1 |
| Armstrong, VW; Oellerich, M | 1 |
| Annesley, TM; Buchanan, N; Kurzyniec, S; Nordblom, GD; Pool, W; Reily, M; Roberts, WL; Talaat, R | 1 |
| Cheshire, WP | 1 |
| Johnson, J; Wrenn, K | 1 |
| Dasgupta, A; Schlette, E | 1 |
| Deleu, D; Koul, R | 1 |
| Dieckman, B; Snelson, C | 1 |
| Stewart-Amidei, C | 1 |
| Blackshear, JL; Bondy, LR; Keegan, MT; Lanier, WL | 1 |
| Cheng, T; Lin, Y; Song, S | 1 |
| Fischer, JH; Fischer, PA; Patel, TV | 1 |
| Kokwaro, GO; Muchohi, SN; Newton, CR; Ogutu, BR; Otieno, GO | 1 |
| Clements, EA; Cochran, MS; Coplin, WM; O'Neil, BJ; Rebuck, JA; Rhoney, DH | 1 |
| Bergin, AM; Connolly, M | 1 |
| Manno, EM | 1 |
| Applebaum, J; Belmaker, RH; Levine, J | 1 |
| Fleisher, D; Flynn, G; Forsberg, M; Heimbach, T; Leppänen, J; Li, LY; Matsunaga, Y; Oh, DM; Savolainen, J | 1 |
| Edwards, G; Kokwaro, GO; Muchohi, SN; Newton, CR; Ogutu, BR; Otieno, GO; Watkins, WM | 1 |
| Fleisher, D; Garcia, G; Heimbach, T; Li, LY; Oh, DM; Rodríguez-Hornedo, N | 1 |
| Patsalos, PN; Wang, X | 1 |
| Chiu, AP; Orlinsky, M; Rudis, MI; Swadron, SP; Touchette, DR | 1 |
| Horowitz, BZ | 1 |
| Azimian, K; Beringer, P; Fort, D; Orlinsky, M; Rudis, MI; Swadron, SP | 1 |
| Benjamin, A; McDonough, JH; McMonagle, JD; Rowland, T; Shih, TM | 1 |
| Hahn, JS; Hsu, D; Sandborg, C | 1 |
| Ault, MJ | 1 |
| Scheinfeld, N | 1 |
| Kher, KK; McBryde, KD; Wilcox, J | 1 |
| Auvinen, A; Eriksson, K; Huhtala, H; Koivikko, M; Kuusela, AL; Metsäranta, P | 1 |
| Adams, BD; Buckley, NH; Kim, JY; Tipps, LB | 1 |
| Harrington, L | 1 |
| Bell, MJ; Weinstein, S | 1 |
| Braun, L; DiFazio, MP; Freedman, S; Hickey, P | 1 |
| Cohen, LB | 1 |
| Bialer, M | 2 |
| Bankstahl, JP; Löscher, W | 1 |
| Paparella, S; Taylor, K | 1 |
| Kuehn, BM | 1 |
| Platts-Mills, T; Strohkirch, J | 1 |
| Anand, KP; Kashyap, AS; Kashyap, S | 1 |
| Lai, Y; Li, N; Yuan, H | 1 |
| Eriksson, K; Kälviäinen, R; Keränen, T | 1 |
| Farooq, MU; Kassab, MY; Lobeck, IN; Majid, A; Xie, Y | 1 |
| Trinka, E | 1 |
| Baulac, M; Navarro, V | 1 |
| Kohn, J; Miller, AD; Schmiesing, CW | 1 |
| Asadi-Pooya, AA; Ashkenazi, A; Sperling, MR; Zangaladze, A | 1 |
| Farooque, P; Khurana, DS; Melvin, JJ | 1 |
| Akiyama, T; Otsubo, H | 1 |
| Aaronson, PM; Belgado, BS; Kunisaki, TA; Spillane, JP | 1 |
| Traynor, K | 1 |
| LaRoche, SM; Shivdat-Nanhoe, R | 1 |
| Manor, SM; Ranzino, AM; Sorrells, KR | 1 |
| Lindsell, CJ; Shutter, LA; Steinbaugh, LA; Szaflarski, JP | 1 |
| Bajwa, RP; Gross, TG; Pai, V; Skeens, M; Soni, S; Termuhlen, AM | 1 |
| Kasai, H; Kumagai, Y; Shimasaki, S; Shimizu, K; Tanaka, J | 1 |
| Hiroki, T; Inoue, Y; Kobayashi, S; Shimasaki, S; Shimizu, K; Usui, N | 1 |
| Alldredge, B; Bell, R; Bleck, TP; Brophy, GM; Claassen, J; Glauser, T; LaRoche, SM; Riviello, JJ; Shutter, L; Sperling, MR; Treiman, DM; Vespa, PM | 1 |
| Al Sherbini, K; Jensen, MB; Sattar, A | 1 |
| Boyer, EW; Burns, JM; Manno, M; Marino, A; Rhyee, S | 1 |
| Shaikh, AG | 1 |
| Broglio, KR; Connor, JT; Elm, JJ | 1 |
| Husain, AM | 2 |
| Bleck, T; Chamberlain, J; Cloyd, J; Cock, H; Connor, J; Elm, J; Fountain, N; Jones, E; Kapur, J; Lowenstein, D; Shinnar, S; Silbergleit, R; Treiman, D; Trinka, E | 1 |
| Chengo, EM; Crawley, J; Fegan, G; Gwer, SA; Idro, RI; Kihara, MN; Kirkham, FJ; Kivaya, E; Mpoya, A; Muchohi, SN; Newton, CR; Ogutu, BR | 1 |
| Cyran, SE; Grageda, M; Halstead, ES; Saini, AP; Trout, LC | 1 |
| Bansal, S; Blalock, D; Carpenter, JL; Dean, NP; Kebede, T | 1 |
| Gross, MH; Hoffman, RS | 1 |
| Yamanouchi, H | 1 |
| Akasaka, M; Hasegawa, T; Ishidou, Y; Kikuchi, K; Nakazawa, M; Niijima, S; Okumura, A; Shima, T; Shimizu, T; Suzuki, T; Takanashi, J; Yamamoto, A | 1 |
| Al-Mufti, F; Claassen, J | 1 |
| Abe, S; Igarashi, A; Ikeno, M; Nakahara, E; Nakazawa, M; Niijima, S; Okumura, A; Shimizu, T; Toda, S; Yamashita, S | 1 |
| Aljarallah, S; Eubanks, JH; Gao, X; Huang, Y; McDonald, R; Patel, N; Peng, J; Wang, J; Wu, C; Zhang, L | 2 |
| Cloyd, JC; Coles, LD; Leppik, IE; Mishra, U; Patterson, EE; Rivers, Z | 1 |
| Bush, W; Cloyd, JC; Coles, LD; Leppik, IE; Patterson, EE; Podell, M; Vite, CH | 1 |
| Acquisto, NM; Forrest, A; Haas, CE; Huntress, JD; Kaucher, KA; Kaufman, DC; Rao, GG | 1 |
| Drumheller, BC; Garbovsky, LA; Perrone, J | 1 |
| Borowicz, KK; Czuczwar, SJ; Popławska, M | 1 |
| Messinger, MM; Moffett, BS; Wilfong, A | 1 |
| Alves, G; Antunes Viegas, D; Falcão, A; Francisco, J; Rodrigues, M; Santos, AO | 1 |
| Kaagaza, M; Krishna, AS; Lefevre, C; Patel, V; Wittkamp, M | 1 |
| Dolce, AM; Reiber, DC; Sirsi, D; Thodeson, DM | 1 |
| Bell, MJ; Boyle, LN; Ellenbogen, RG; Giza, CC; Groner, JI; Kannan, N; Mink, RB; Mitchell, PH; Ostahowski, PJ; Qiu, Q; Vavilala, MS; Wainwright, MS; Zatzick, DF | 1 |
| Friese, R; Gruessner, A; Joseph, B; Khalil, M; Kulvatunyou, N; Latifi, R; O'Keeffe, T; Rhee, P; Wynne, J; Zangbar, B | 1 |
| Haruyama, S; Nakamura, M; Nishio, D; Ohmori, S; Omoto, D; Saito-Sasaki, N; Sawada, Y; Yoshioka, M | 1 |
| Hwang, IG; Kim, DW; Kim, HK; Koh, IS | 1 |
| Blades Golubovic, S; Rossmeisl, JH | 1 |
| Baldwin, R; Lumley, L; Niquet, J; Norman, K; Suchomelova, L; Wasterlain, CG | 1 |
| Daidoji, H; Doi, K; Hashimoto, H; Hiruma, T; Inokuchi, R; Morimura, N; Nakamura, K; Naraba, H; Sonoo, T; Tokunaga, K | 1 |
| Blunck, JR; Croom, JE; Fields, RK; Newman, JW | 1 |
| Agier, MS; Beau-Salinas, F; Bejan-Angoulvant, T; Bouquet, E; Jonville-Béra, AP; Simon, C; Vrignaud, L | 1 |
| Arya, R; Aungaroon, G; Byars, AW; Greiner, HM; Holland, KD; Horn, PS; Mangano, FT; Zea Vera, A | 1 |
| Kamath, P; Kamath, RL; Marla, J; Pai, N; Patel, K; Prabhu, MA; Rai, MK | 1 |
| Hayashi, H; Hayashi, Y; Hirai, K; Itoh, Y; Niwa, T; Ohno, Y; Suzuki, A; Suzuki, K; Yamada, Y | 1 |
| Bhapkar, M; Dombrowski, KE; Gallentine, WB; Gerard, EE; Gupta, PK; Hahn, CD; Halford, JJ; Herman, ST; Hirsch, LJ; Husain, AM; Jones, JM; Kolls, BJ; LaRoche, SM; Lee, JW; Lokhnygina, Y; Minazad, Y; Palade, A; Sinha, SR; Swisher, CB; Westover, MB | 1 |
| Erklauer, J; Galati, M; Moffett, BS; Riviello, JJ; Schmees, LR; Weingarten, MM | 1 |
| Priano, J; Schiel, J; Servati, N; Vilar, J | 1 |
| Wainwright, MS | 1 |
| Fujita, K; Iijima, K; Ishida, Y; Kurosawa, H; Maruyama, A; Morioka, I; Nagase, H; Nishiyama, M; Nozu, K; Takada, S; Tanaka, T; Taniguchi-Ikeda, M; Tomioka, K; Toyoshima, D; Uetani, Y; Yamaguchi, H | 1 |
| Iwai, M; Kondo, F; Ogawa, T; Seno, H; Suzuki, T; Ueyama, J | 1 |
| Alaniz, C; Burghardt, D; DasGupta, R | 1 |
| Abbott, J; Bendtsen, L; Braschinsky, M; Cruccu, G; Di Stefano, G; Donnet, A; Eide, PK; Jensen, TS; Leal, PRL; Maarbjerg, S; May, A; Nurmikko, T; Obermann, M; Zakrzewska, JM | 1 |
| Gaínza-Lein, M; Lamb, N; Loddenkemper, T; Sánchez Fernández, I | 1 |
| Higuchi, K; Hirakawa, M; Hirota, T; Ieiri, I; Kakara, M; Kashihara, Y; Yamashita, D | 1 |
| Alves, G; Peixoto, D; Pires, PC; Rodrigues, M; Santos, AO; Teixeira, I | 1 |
| Barsan, W; Chamberlain, JM; Cloyd, J; Cock, H; Connor, JT; Conwit, R; Elm, J; Fountain, N; Kapur, J; Lowenstein, D; Meinzer, C; Shinnar, S; Silbergleit, R | 1 |
| Armahizer, M; Noval, M; Seung, H | 1 |
| Dribin, T; Walters, E; Wurster Ovalle, V; Yin, S | 1 |
| Kandasamy, S; Krishnamoorthi, N; Nalisetty, S; Sangaralingam, T; Sridharan, B; Vijayakumar, V | 1 |
| Anand, V; Chakrabarty, B | 1 |
| Bhartiya, S; Gavli, V; Patil, R; Rajadhyaksha, S; Srivastava, K | 1 |
| Appleton, RE | 1 |
| Babcock, L; Barsan, W; Bleck, TP; Chamberlain, JM; Cloyd, J; Cock, H; Connor, JT; Conwit, R; Elm, J; Fountain, NB; Holsti, M; Kapur, J; Lowenstein, D; Meinzer, C; Rogers, A; Shinnar, S; Silbergleit, R; Underwood, E | 1 |
| Ardinger, CE; Berger, KE; Dunn, EN; Haines, KM; Jackson Piercy, CE; Lee-Stubbs, RB; Matson, LM; McCarren, HS; McDonough, JH; Miller-Smith, SM; Whitten, KA | 1 |
| Madaan, P; Sahu, JK | 1 |
| Bleck, TP; Chamberlain, JM; Cloyd, JC; Cock, HR; Coles, LD; Conwit, RA; Elm, JJ; Fountain, NB; Kapur, J; Lowenstein, DH; Sathe, AG; Shinnar, S; Silbergleit, R | 1 |
| Panda, PK; Sharawat, IK | 1 |
| Fushimi, K; Matsui, H; Nakamura, K; Nakano, H; Naraba, H; Ohbe, H; Takahashi, Y; Yasunaga, H | 1 |
| Babl, FE; Hirsch, LJ; Josephson, SA; Wu, K | 1 |
| Hayashi, T; Noguchi, Y; Tachi, T; Takaoka, M; Teramachi, H | 1 |
| Alix, V; Jackson, AH; James, M; Singh, R; Visintainer, PF | 1 |
| Abend, NS; Amengual-Gual, M; Anderson, A; Arya, R; Brenton, JN; Carpenter, JL; Chapman, K; Clark, J; Farias-Moeller, R; Gaillard, WD; Gaínza-Lein, M; Glauser, T; Goldstein, JL; Goodkin, HP; Guerriero, RM; Kapur, K; Lai, YC; Loddenkemper, T; McDonough, TL; Mikati, MA; Morgan, LA; Novotny, EJ; Ostendorf, AP; Payne, ET; Peariso, K; Piantino, J; Riviello, JJ; Sannagowdara, K; Tasker, RC; Tchapyjnikov, D; Topjian, A; Vasquez, A; Wainwright, MS; Wilfong, A; Williams, K | 1 |
| Alves, G; Pires, PC; Rodrigues, M; Santos, AO; Santos, LT | 1 |
| Hayashi, H; Hayashi, Y; Hirai, K; Kobayashi, R; Nishida, S; Niwa, T; Shimizu, S; Shimohata, T; Sugiyama, T; Suzuki, A; Takekoshi, A; Yamada, Y | 1 |
| Babcock, L; Brundage, RC; Chamberlain, JM; Cloyd, JC; Cock, HR; Coles, LD; Elm, JJ; Fountain, NB; Ivaturi, V; Kapur, J; Lowenstein, DH; Mishra, U; Sathe, AG; Shinnar, S; Silbergleit, R | 1 |
| Aizawa, Y; Matsunaga, M; Saitoh, A; Soma, N | 1 |
| Catenacci, V; Choong, K; Duffett, M; Hewitt, M; Jones, K; Klowak, JA; Rochwerg, B | 1 |
| Broomall, E; Ritter, DM; Tian, C | 1 |
| Asami, M; Egawa, S; Hoshiyama, E; Inoue, Y; Kaneko, J; Kimura, A; Kondo, Y; Maruo, K; Marushima, A; Nakamura, K; Takahashi, Y; Yamada, T; Yonekawa, C | 1 |
| Gottlieb, M; Long, B | 1 |
| Alves, G; Fazendeiro, AC; Pires, PC; Rodrigues, M; Santos, AO | 1 |
| Clay, JL; Fountain, NB | 1 |
| Amano, Y; Asayama, B; Honjo, K; Kyono, M; Nakamura, H; Noro, S; Okuma, M; Sako, K; Seo, Y | 1 |
| Arai, S; Inoue, A; Kitada, Y; Nagashima, R; Ogata, T; Shiraki, K; Takasaki, I; Ueda, T | 1 |
| Andersen, ASS; Asghar, MS; Bendtsen, L; Heinskou, TB; Maarbjerg, S; Noory, N; Rossen, B; Smilkov, EA | 1 |
| Chamberlain, JM; Coralic, Z; Kapur, J; Olson, KR; Overbeek, D; Silbergleit, R | 1 |
| Asami, M; Egawa, S; Fukuda, Y; Hoshiyama, E; Inoue, Y; Ishikawa, E; Kaneko, J; Kimura, A; Kondo, Y; Maruo, K; Marushima, A; Matsumaru, Y; Mochizuki, M; Nakamoto, H; Nakamura, K; Takahashi, Y; Uchida, M; Unemoto, K; Yamada, T; Yonekawa, C | 1 |
| Lee, BL; Lee, KS | 1 |
41 review(s) available for phenytoin and fosphenytoin
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
New anticonvulsant drugs. Focus on flunarizine, fosphenytoin, midazolam and stiripentol.
Topics: Adolescent; Adult; Animals; Anticonvulsants; Child; Child, Preschool; Cross-Over Studies; Dioxolanes; Double-Blind Method; Epilepsy; Flunarizine; Humans; Midazolam; Middle Aged; Phenytoin; Pilot Projects; Prodrugs | 1994 |
Fosphenytoin use in children.
Topics: Adolescent; Anticonvulsants; Child; Epilepsy; Humans; Infant, Newborn; Phenytoin | 1996 |
Intravenous administration of fosphenytoin: options for the management of seizures.
Topics: Anticonvulsants; Epilepsy; Humans; Infusions, Parenteral; Phenytoin; Status Epilepticus | 1996 |
Emergency treatment of status epilepticus.
Topics: Anticonvulsants; Emergencies; Epilepsy; Humans; Phenytoin | 1996 |
Intramuscular use of fosphenytoin: an overview.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Injections, Intramuscular; Male; Phenytoin | 1996 |
Pharmacology and pharmacokinetics of fosphenytoin.
Topics: Animals; Anticonvulsants; Epilepsy; Humans; Phenytoin | 1996 |
Safety of fosphenytoin sodium.
Topics: Adult; Anticonvulsants; Biological Availability; Chemistry, Pharmaceutical; Drug Interactions; Epilepsy; Humans; Injections, Intravenous; Phenytoin; Prodrugs | 1996 |
Fosphenytoin (Cerebyx).
Topics: Animals; Anticonvulsants; Chemistry, Pharmaceutical; Humans; Phenytoin; Prodrugs | 1997 |
New drug therapy for acute seizure management.
Topics: Acute Disease; Anticonvulsants; Child; Diazepam; Epilepsy; Humans; Phenytoin; Prodrugs; Seizures; Valproic Acid | 1997 |
Recent advancements in epilepsy.
Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Neurosurgery; Phenylcarbamates; Phenytoin; Pia Mater; Propylene Glycols; Temporal Lobe; Topiramate; Triazines; Vigabatrin | 1997 |
Newer antiepileptic drugs: gabapentin, lamotrigine, felbamate, topiramate and fosphenytoin.
Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Phenylcarbamates; Phenytoin; Propylene Glycols; Topiramate; Triazines | 1998 |
Advances in the medical treatment of epilepsy.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Diazepam; Drug Approval; Drug Design; Drug Interactions; Drug Resistance; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Injections, Intravenous; Ketones; Lamotrigine; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Phenylcarbamates; Phenytoin; Prodrugs; Propylene Glycols; Tiagabine; Topiramate; Triazines; United States; Valproic Acid; Vigabatrin | 1998 |
Fosphenytoin.
Topics: Anticonvulsants; Chemical Phenomena; Chemistry, Physical; Humans; Molecular Structure; Phenytoin; Prodrugs; Tissue Distribution | 1998 |
Antiepileptic drug review: part 2.
Topics: Acetates; Amines; Anticonvulsants; Biological Availability; Cyclohexanecarboxylic Acids; Drug Interactions; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Half-Life; Humans; Lamotrigine; Phenylcarbamates; Phenytoin; Propylene Glycols; Topiramate; Triazines | 1998 |
Pediatric use of intravenous and intramuscular phenytoin: lessons learned.
Topics: Anticonvulsants; Chemistry, Pharmaceutical; Child; Child, Preschool; Dose-Response Relationship, Drug; Epilepsy; Humans; Infant; Infant, Newborn; Infusions, Intravenous; Injections, Intramuscular; Phenytoin | 1998 |
Clinical experience with fosphenytoin in adults: pharmacokinetics, safety, and efficacy.
Topics: Adult; Anticonvulsants; Chemistry, Pharmaceutical; Drug Administration Schedule; Epilepsy; Humans; Infusions, Intravenous; Phenytoin; Seizures | 1998 |
Fosphenytoin. Pharmacoeconomic implications of therapy.
Topics: Anticonvulsants; Humans; Phenytoin; Prodrugs; Randomized Controlled Trials as Topic | 1998 |
Management approaches to prolonged seizures and status epilepticus.
Topics: Anticonvulsants; Benzodiazepines; Diazepam; Drug Administration Schedule; Drug Therapy, Combination; Humans; Lorazepam; Midazolam; Phenobarbital; Phenytoin; Propofol; Seizures; Status Epilepticus; Treatment Outcome | 1999 |
Fosphenytoin and phenytoin in patients with status epilepticus: improved tolerability versus increased costs.
Topics: Anticonvulsants; Humans; Phenytoin; Status Epilepticus | 2000 |
New antiepileptic drugs and preparations.
Topics: Acetates; Administration, Rectal; Age Factors; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Diazepam; Drug Overdose; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Injections, Intravenous; Lamotrigine; Phenylcarbamates; Phenytoin; Propylene Glycols; Topiramate; Triazines; Valproic Acid | 2000 |
Recognizing and managing purple glove syndrome.
Topics: Adult; Anticonvulsants; Disease Progression; Epilepsy, Tonic-Clonic; Extravasation of Diagnostic and Therapeutic Materials; Female; Hand Injuries; Humans; Hydrogen-Ion Concentration; Injections, Intravenous; Neurologic Examination; Nursing Assessment; Patient Care Planning; Phenytoin; Risk Factors; Soft Tissue Injuries; Solubility; Solutions; Syndrome; Time Factors | 2000 |
Fosphenytoin: clinical pharmacokinetics and comparative advantages in the acute treatment of seizures.
Topics: Animals; Anticonvulsants; Drug Interactions; Humans; Phenytoin; Prodrugs; Protein Binding; Seizures | 2003 |
New antiepileptic drug therapies.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Dioxolanes; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Oxcarbazepine; Phenylcarbamates; Phenytoin; Piracetam; Propylene Glycols; Thiazines; Tiagabine; Topiramate; Triazines; Vigabatrin; Zonisamide | 2002 |
New management strategies in the treatment of status epilepticus.
Topics: Anticonvulsants; Benzodiazepines; Emergency Medical Services; Humans; Phenobarbital; Phenytoin; Status Epilepticus; United States; Valproic Acid | 2003 |
Impact of phenytoin therapy on the skin and skin disease.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Child; Connective Tissue Diseases; Drug Eruptions; Drug Hypersensitivity; Epilepsy; Facies; Female; Gingival Hyperplasia; Hirsutism; Humans; Infant, Newborn; Lymphoma; Male; Minerals; Phenytoin; Pregnancy; Pregnancy Complications; Pseudolymphoma; Vascular Diseases; Vitamins | 2004 |
Administer single-site 30-mL intramuscular injection?
Topics: Anticonvulsants; Dose-Response Relationship, Drug; Humans; Injections, Intramuscular; Phenytoin; Prodrugs | 2005 |
Clinical pharmacology of parenteral use of antiepileptic drugs.
Topics: Anticonvulsants; Epilepsy; Humans; Infusions, Intravenous; Injections, Intravenous; Levetiracetam; Pharmaceutical Vehicles; Phenytoin; Piracetam; Solubility; Valproic Acid | 2007 |
Treatment of status epilepticus in children.
Topics: Anticonvulsants; Child; Child, Preschool; Diazepam; Drug Administration Schedule; Drug Therapy, Combination; Emergency Medical Services; Hospitalization; Humans; Lorazepam; Midazolam; Pediatrics; Phenytoin; Practice Guidelines as Topic; Recurrence; Status Epilepticus; Treatment Outcome | 2004 |
Fosphenytoin.
Topics: Adult; Anticonvulsants; Child; Humans; Phenytoin; Prodrugs; Seizures | 2009 |
What is the relative value of the standard anticonvulsants: Phenytoin and fosphenytoin, phenobarbital, valproate, and levetiracetam?
Topics: Anticonvulsants; Benzodiazepines; Humans; Levetiracetam; Phenobarbital; Phenytoin; Piracetam; Prodrugs; Status Epilepticus; Treatment Outcome; Valproic Acid | 2009 |
[Antiepileptic drugs in North America].
Topics: Anticonvulsants; Carbamazepine; Drug Approval; Fructose; Humans; Japan; Lamotrigine; Levetiracetam; Lorazepam; North America; Phenytoin; Piracetam; Topiramate; Triazines | 2010 |
Severe cardiomyopathy in an infant after iatrogenic fosphenytoin overdose.
Topics: Anticonvulsants; Cardiomyopathies; Drug Overdose; Echocardiography, Doppler; Female; Heart Function Tests; Humans; Iatrogenic Disease; Infant; Medication Errors; Monitoring, Physiologic; Phenytoin; Prognosis; Seizures; Severity of Illness Index | 2014 |
[Treatment of status epilepticus].
Topics: Anesthesia, General; Diazepam; Drug Administration Routes; Evidence-Based Medicine; Humans; Hypothermia, Induced; Intensive Care Units; Midazolam; Phenobarbital; Phenytoin; Practice Guidelines as Topic; Propofol; Status Epilepticus; Thiopental; Time Factors | 2014 |
Neurocritical care: status epilepticus review.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Benzodiazepines; Critical Care; Electroencephalography; Emergency Medical Services; Female; Humans; Male; Middle Aged; Phenytoin; Practice Guidelines as Topic; Status Epilepticus; Treatment Outcome; Young Adult | 2014 |
Purple Glove Syndrome after Phenytoin or Fosphenytoin Administration: Review of Reported Cases and Recommendations for Prevention.
Topics: Anticonvulsants; Humans; Male; Middle Aged; Phenytoin; Risk Factors; Syndrome | 2015 |
Lacosamide in status epilepticus: Update on the TRENdS study.
Topics: Acetamides; Anticonvulsants; Critical Illness; Humans; Lacosamide; Phenytoin; Recurrence; Seizures; Status Epilepticus | 2015 |
Status epilepticus in dogs and cats, part 2: treatment, monitoring, and prognosis.
Topics: Animals; Anticonvulsants; Cat Diseases; Cats; Dog Diseases; Dogs; Electroencephalography; Phenytoin; Prognosis; Randomized Controlled Trials as Topic; Seizures; Status Epilepticus | 2017 |
Meta-analysis and cost-effectiveness of second-line antiepileptic drugs for status epilepticus.
Topics: Anticonvulsants; Benzodiazepines; Cost-Benefit Analysis; Decision Support Techniques; Humans; Lacosamide; Levetiracetam; Phenobarbital; Phenytoin; Status Epilepticus; Treatment Failure; Valproic Acid | 2019 |
Levetiracetam Versus Phenytoin or Fosphenytoin for Second-Line Treatment of Pediatric Status Epilepticus: A Meta-Analysis.
Topics: Anticonvulsants; Child; Humans; Levetiracetam; Phenytoin; Status Epilepticus | 2021 |
A critical review of fosphenytoin sodium injection for the treatment of status epilepticus in adults and children.
Topics: Adult; Anticonvulsants; Child; Humans; Levetiracetam; Phenytoin; Status Epilepticus | 2022 |
31 trial(s) available for phenytoin and fosphenytoin
| Article | Year |
|---|---|
Evaluation of the pharmacokinetic interaction between diazepam and ACC-9653 (a phenytoin prodrug) in healthy male volunteers.
Topics: Adult; Diazepam; Drug Interactions; Electrocardiography; Humans; Male; Phenytoin; Prodrugs; Protein Binding; Ultrafiltration | 1990 |
Phenytoin prodrug: preclinical and clinical studies.
Topics: Adult; Aged; Clinical Trials as Topic; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Placebos; Prodrugs; Random Allocation | 1989 |
Bioavailability of ACC-9653 (phenytoin prodrug).
Topics: Biological Availability; Clinical Trials as Topic; Humans; Phenytoin; Prodrugs; Random Allocation | 1989 |
New anticonvulsant drugs. Focus on flunarizine, fosphenytoin, midazolam and stiripentol.
Topics: Adolescent; Adult; Animals; Anticonvulsants; Child; Child, Preschool; Cross-Over Studies; Dioxolanes; Double-Blind Method; Epilepsy; Flunarizine; Humans; Midazolam; Middle Aged; Phenytoin; Pilot Projects; Prodrugs | 1994 |
Safety and tolerance of multiple doses of intramuscular fosphenytoin substituted for oral phenytoin in epilepsy or neurosurgery.
Topics: Aged; Aged, 80 and over; Anticonvulsants; Drug Tolerance; Epilepsy; Female; Humans; Male; Middle Aged; Neurosurgery; Phenytoin | 1996 |
Intramuscular fosphenytoin (Cerebyx) in patients requiring a loading dose of phenytoin.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Dose-Response Relationship, Drug; Follow-Up Studies; Humans; Injections, Intramuscular; Middle Aged; Phenytoin; Prodrugs | 1997 |
Clinical experience with fosphenytoin in children.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Infusions, Intravenous; Injections, Intramuscular; Male; Phenytoin; Seizures | 1998 |
Fosphenytoin. Pharmacoeconomic implications of therapy.
Topics: Anticonvulsants; Humans; Phenytoin; Prodrugs; Randomized Controlled Trials as Topic | 1998 |
Pharmacokinetics of fosphenytoin in patients with hepatic or renal disease.
Topics: Adult; Anticonvulsants; Chromatography, High Pressure Liquid; Humans; Infusions, Intravenous; Kidney Failure, Chronic; Liver Cirrhosis; Male; Middle Aged; Phenytoin; Prodrugs | 1999 |
Cost-minimization analysis of phenytoin and fosphenytoin in the emergency department.
Topics: Anticonvulsants; Cost Control; Emergency Medical Services; Humans; Models, Economic; Monte Carlo Method; Phenytoin; Prodrugs; Prospective Studies; Status Epilepticus | 2000 |
Fosphenytoin: pharmacokinetics and tolerance of intramuscular loading doses.
Topics: Adolescent; Anticonvulsants; Child; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Epilepsy; Female; Humans; Injections, Intramuscular; Male; Phenytoin; Placebos; Treatment Outcome | 2001 |
Phenytoin pharmacokinetics and clinical effects in African children following fosphenytoin and chloramphenicol coadministration.
Topics: Anti-Bacterial Agents; Anticonvulsants; Area Under Curve; Cefotaxime; Child, Preschool; Chloramphenicol; Drug Therapy, Combination; Female; Half-Life; Humans; Infant; Injections, Intramuscular; Injections, Intravenous; Malaria; Male; Models, Biological; Phenytoin; Seizures | 2002 |
Randomized evaluation of adverse events and length-of-stay with routine emergency department use of phenytoin or fosphenytoin.
Topics: Adult; Aged; Aged, 80 and over; Drug Administration Schedule; Drug Therapy, Combination; Emergency Service, Hospital; Emergency Treatment; Epilepsy; Epilepsy, Post-Traumatic; Extravasation of Diagnostic and Therapeutic Materials; Female; Humans; Hypotension; Length of Stay; Male; Middle Aged; Phenytoin | 2002 |
A comparison of phenytoin-loading techniques in the emergency department.
Topics: Administration, Oral; Adult; Anticonvulsants; Area Under Curve; Dose-Response Relationship, Drug; Emergency Medical Services; Female; Humans; Infusions, Intravenous; Length of Stay; Male; Outcome and Process Assessment, Health Care; Phenytoin; Prospective Studies; Seizures; Treatment Outcome | 2004 |
Clinical trial: a dose-response study of fospropofol disodium for moderate sedation during colonoscopy.
Topics: Aged; Anticonvulsants; Colonoscopy; Conscious Sedation; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Midazolam; Middle Aged; Patient Satisfaction; Phenytoin | 2008 |
Bioavailability of intravenous fosphenytoin sodium in healthy Japanese volunteers.
Topics: Adult; Anticonvulsants; Area Under Curve; Biological Availability; Cross-Over Studies; Double-Blind Method; Humans; Infusions, Intravenous; Male; Phenytoin; Prodrugs | 2013 |
Bayesian adaptive trials offer advantages in comparative effectiveness trials: an example in status epilepticus.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Bayes Theorem; Child; Child, Preschool; Comparative Effectiveness Research; Early Termination of Clinical Trials; Emergency Service, Hospital; Humans; Intention to Treat Analysis; Levetiracetam; Middle Aged; Models, Statistical; Phenytoin; Piracetam; Randomized Controlled Trials as Topic; Research Design; Status Epilepticus; Treatment Outcome; Valproic Acid; Young Adult | 2013 |
The established status epilepticus trial 2013.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Child; Child, Preschool; Double-Blind Method; Humans; Levetiracetam; Middle Aged; Phenytoin; Piracetam; Research Design; Status Epilepticus; Treatment Outcome; Valproic Acid; Young Adult | 2013 |
Fosphenytoin for seizure prevention in childhood coma in Africa: a randomized clinical trial.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Coma; Double-Blind Method; Electroencephalography; Female; Humans; Infant; Injections, Intramuscular; Kenya; Male; Phenytoin; Placebos; Seizures; Treatment Outcome | 2013 |
Canine status epilepticus treated with fosphenytoin: A proof of principle study.
Topics: Animals; Anticonvulsants; Benzodiazepines; Dogs; Double-Blind Method; Female; Infusions, Intravenous; Male; Phenytoin; Prospective Studies; Status Epilepticus; Time Factors; Treatment Outcome | 2015 |
Relative bioavailability of orally administered fosphenytoin sodium injection compared with phenytoin sodium injection in healthy volunteers.
Topics: Administration, Oral; Adult; Cross-Over Studies; Female; Food-Drug Interactions; Humans; Male; Phenytoin | 2015 |
Time-Dependent Decline in Serum Phenytoin Concentration With Heightened Convulsive Seizure Risk by Prolonged Administration of Fosphenytoin in Japanese: A Retrospective Study.
Topics: Administration, Intravenous; Adolescent; Adult; Aged; Anticonvulsants; Bayes Theorem; Drug Dosage Calculations; Female; Humans; Japan; Male; Middle Aged; Phenytoin; Prodrugs; Retrospective Studies; Seizures; Time Factors; Young Adult | 2018 |
Randomized trial of lacosamide versus fosphenytoin for nonconvulsive seizures.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Brain Waves; Cross-Over Studies; Electroencephalography; Epilepsy, Generalized; Female; Glasgow Coma Scale; Humans; Lacosamide; Male; Middle Aged; Phenytoin; Prospective Studies; Single-Blind Method; Treatment Outcome | 2018 |
Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus.
Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Double-Blind Method; Drug Resistance; Female; Humans; Hypotension; Infusions, Intravenous; Injections, Intramuscular; Levetiracetam; Male; Middle Aged; Phenytoin; Status Epilepticus; Valproic Acid; Young Adult | 2019 |
Clinical Effectiveness of Levetiracetam Compared to Fosphenytoin in the Treatment of Benzodiazepine Refractory Convulsive Status Epilepticus.
Topics: Anticonvulsants; Benzodiazepines; Child; Humans; Levetiracetam; Neoplasm Recurrence, Local; Phenytoin; Status Epilepticus; Treatment Outcome | 2020 |
Efficacy of levetiracetam, fosphenytoin, and valproate for established status epilepticus by age group (ESETT): a double-blind, responsive-adaptive, randomised controlled trial.
Topics: Adolescent; Adult; Age Distribution; Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Infant; Levetiracetam; Male; Middle Aged; Phenytoin; Status Epilepticus; Valproic Acid; Young Adult | 2020 |
The association of patient weight and dose of fosphenytoin, levetiracetam, and valproic acid with treatment success in status epilepticus.
Topics: Adolescent; Adult; Anticonvulsants; Body Weight; Dose-Response Relationship, Drug; Female; Humans; Levetiracetam; Male; Phenytoin; Single-Blind Method; Status Epilepticus; Treatment Outcome; Valproic Acid; Young Adult | 2020 |
Early Exposure of Fosphenytoin, Levetiracetam, and Valproic Acid After High-Dose Intravenous Administration in Young Children With Benzodiazepine-Refractory Status Epilepticus.
Topics: Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Infusions, Intravenous; Levetiracetam; Male; Phenytoin; Protein Binding; Status Epilepticus; Valproic Acid | 2021 |
Levetiracetam versus fosphenytoin as a second-line treatment after diazepam for status epilepticus: study protocol for a multicenter non-inferiority designed randomized control trial.
Topics: Adult; Anticonvulsants; Diazepam; Humans; Japan; Levetiracetam; Multicenter Studies as Topic; Neoplasm Recurrence, Local; Phenytoin; Randomized Controlled Trials as Topic; Status Epilepticus; Treatment Outcome | 2021 |
Treatment of Toxin-Related Status Epilepticus With Levetiracetam, Fosphenytoin, or Valproate in Patients Enrolled in the Established Status Epilepticus Treatment Trial.
Topics: Adult; Alcoholism; Analgesics, Opioid; Anticonvulsants; Benzodiazepines; Child; Cocaine; Female; Humans; Levetiracetam; Male; Phenytoin; Prospective Studies; Seizures; Status Epilepticus; Substance Withdrawal Syndrome; Valproic Acid | 2022 |
Levetiracetam versus fosphenytoin as a second-line treatment after diazepam for adult convulsive status epilepticus: a multicentre non-inferiority randomised control trial.
Topics: Adult; Anticonvulsants; Diazepam; Humans; Levetiracetam; Phenytoin; Seizures; Status Epilepticus; Treatment Outcome | 2023 |
168 other study(ies) available for phenytoin and fosphenytoin
| Article | Year |
|---|---|
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Pharmacokinetics and safety of a phenytoin prodrug given i.v. or i.m. in patients.
Topics: Adult; Aged; Electrocardiography; Epilepsy; Female; Half-Life; Hemodynamics; Humans; Infusions, Intravenous; Injections, Intramuscular; Male; Middle Aged; Phenytoin; Prodrugs | 1990 |
Efficacy of ACC-9653 (a phenytoin prodrug) in experimental status epilepticus in the rat.
Topics: Animals; Male; Phenytoin; Prodrugs; Rats; Rats, Inbred Strains; Status Epilepticus | 1990 |
Phenytoin prodrug 3-phosphoryloxymethyl phenytoin (ACC-9653): pharmacokinetics in patients following intravenous and intramuscular administration.
Topics: Chromatography, High Pressure Liquid; Female; Humans; Injections, Intramuscular; Injections, Intravenous; Male; Phenytoin; Prodrugs | 1989 |
Pharmacology of ACC-9653 (phenytoin prodrug).
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Epilepsy; Heart Rate; Mice; Phenytoin; Prodrugs | 1989 |
Emergency management of seizures: an overview.
Topics: Diazepam; Emergencies; Humans; Lidocaine; Lorazepam; Phenytoin; Prodrugs; Seizures; Status Epilepticus | 1989 |
Safety, tolerance and pharmacokinetics of intravenous doses of the phosphate ester of 3-hydroxymethyl-5,5-diphenylhydantoin: a new prodrug of phenytoin.
Topics: Adult; Chromatography, High Pressure Liquid; Electrocardiography; Hemodynamics; Humans; Infusions, Intravenous; Male; Phenytoin; Prodrugs; Spectrophotometry, Ultraviolet | 1988 |
Phenytoin prodrugs V: In vivo evaluation of some water-soluble phenytoin prodrugs in dogs.
Topics: Administration, Oral; Animals; Biological Availability; Chromatography, Gas; Dogs; Half-Life; Injections, Intravenous; Kinetics; Phenytoin; Solubility | 1984 |
Phenytoin prodrugs VI: In vivo evaluation of a phosphate ester prodrug of phenytoin after parenteral administration to rats.
Topics: Animals; Biological Availability; Injections, Intramuscular; Injections, Intravenous; Injections, Subcutaneous; Male; Phenytoin; Rats; Rats, Inbred Strains | 1984 |
Binding of fosphenytoin, phosphate ester pro drug of phenytoin, to human serum proteins and competitive binding with carbamazepine, diazepam, phenobarbital, phenylbutazone, phenytoin, valproic acid or warfarin.
Topics: Adult; Anticonvulsants; Binding Sites; Binding, Competitive; Blood Proteins; Humans; In Vitro Techniques; Kinetics; Male; Orosomucoid; Phenytoin; Protein Binding; Serum Albumin; Warfarin | 1995 |
Bioavailability studies of drugs with nonlinear pharmacokinetics: II. Absolute bioavailability of intravenous phenytoin prodrug at therapeutic phenytoin serum concentrations determined by double-stable isotope technique.
Topics: Adult; Biological Availability; Carbon Isotopes; Humans; Male; Middle Aged; Nitrogen Isotopes; Phenytoin; Prodrugs | 1993 |
Reconversion of fosphenytoin in the presence of intestinal alkaline phosphatase.
Topics: Alkaline Phosphatase; Animals; Anticonvulsants; Biotransformation; Colon; In Vitro Techniques; Intestinal Mucosa; Intestines; Jejunum; Kinetics; Male; Nitrophenols; Organophosphorus Compounds; Phenytoin; Prodrugs; Rats; Rats, Wistar | 1995 |
Use of parenteral antiepileptic drugs and the role for fosphenytoin.
Topics: Anticonvulsants; Epilepsy; Humans; Infusions, Parenteral; Phenytoin | 1996 |
Fosphenytoin injection introduced as replacement for Dilantin injection.
Topics: Administration, Oral; Anticonvulsants; Humans; Injections, Intramuscular; Injections, Intravenous; Phenytoin; Prodrugs; Seizures; Status Epilepticus | 1996 |
Fosphenytoin safety and economics.
Topics: Anticonvulsants; Epilepsy; Humans; Phenytoin; Prescription Fees; Prodrugs | 1996 |
Fosphenytoin: a feasible alternative to phenytoin for seizure therapy.
Topics: Anticonvulsants; Humans; Phenytoin; Seizures | 1996 |
Reactions to fosphenytoin editorial and review article.
Topics: Anticonvulsants; Conflict of Interest; Humans; Periodicals as Topic; Phenytoin; Publication Bias | 1997 |
Reactions to fosphenytoin editorial and review article.
Topics: Anticoagulants; Conflict of Interest; Humans; Peer Review, Research; Phenytoin; Publication Bias | 1997 |
Reactions to fosphenytoin editorial and review article.
Topics: Anticonvulsants; Conflict of Interest; Humans; Injections, Intravenous; Phenytoin; Publication Bias; Risk Factors | 1997 |
Reactions to fosphenytoin editorial and review article.
Topics: Anticonvulsants; Cost Savings; Epilepsy; Humans; Phenytoin | 1997 |
Reactions to fosphenytoin editorial and review article.
Topics: Anticonvulsants; Conflict of Interest; Health Care Costs; Humans; Phenytoin; Publication Bias | 1997 |
Equivalence dosing.
Topics: Adult; Anticonvulsants; Humans; Male; Mathematics; Medication Errors; Phenytoin; Therapeutic Equivalency | 1997 |
Stability of fosphenytoin sodium with intravenous solutions in glass bottles, polyvinyl chloride bags, and polypropylene syringes.
Topics: Chromatography, High Pressure Liquid; Drug Packaging; Drug Stability; Glass; Infusions, Intravenous; Phenytoin; Polypropylenes; Polyvinyl Chloride; Solutions; Syringes; Temperature; Time Factors | 1997 |
Fosphenytoin: worth the cost?
Topics: Anticonvulsants; Drug Costs; Drug Industry; Humans; Marketing of Health Services; Phenytoin | 1997 |
Simultaneous rapid high-performance liquid chromatographic determination of phenytoin and its prodrug, fosphenytoin in human plasma and ultrafiltrate.
Topics: Anticonvulsants; Chromatography, High Pressure Liquid; Humans; Phenytoin; Prodrugs; Sensitivity and Specificity; Spectrophotometry, Ultraviolet | 1997 |
A new phenytoin prodrug, Cerebyx.
Topics: Anticonvulsants; Humans; Phenytoin; Prodrugs | 1997 |
Fact versus opinion in the judgment on fosphenytoin articles.
Topics: Conflict of Interest; Drug Industry; Humans; Pharmacists; Phenytoin; Prodrugs; Publication Bias | 1997 |
Fact versus opinion in the judgment on fosphenytoin articles.
Topics: Conflict of Interest; Drug Industry; Humans; Pharmacists; Phenytoin; Prodrugs; Publication Bias | 1997 |
Cost of fosphenytoin.
Topics: Anticonvulsants; Cost-Benefit Analysis; Drug Costs; Humans; Phenytoin; Seizures | 1998 |
Cost of fosphenytoin.
Topics: Anticonvulsants; Drug Costs; Drug Industry; Drugs, Generic; Humans; Phenytoin | 1998 |
Cross-reactivity of fosphenytoin in four phenytoin immunoassays.
Topics: Anticonvulsants; Cross Reactions; Drug Monitoring; Humans; Immunoassay; Phenytoin; Prodrugs; Reproducibility of Results | 1998 |
More on fosphenytoin (Cerebyx) dosing.
Topics: Anticonvulsants; Emergency Treatment; Humans; Phenytoin; Practice Guidelines as Topic; Therapeutic Equivalency | 1998 |
Fosphenytoin in the emergency department.
Topics: Anticonvulsants; Emergency Service, Hospital; Humans; Phenytoin; Prodrugs; Seizures; Status Epilepticus | 1998 |
Anticonvulsant effect of fosphenytoin in amygdala-kindled rats: comparison with phenytoin.
Topics: Amygdala; Animals; Anticonvulsants; Biological Availability; Dose-Response Relationship, Drug; Epilepsy, Complex Partial; Female; Kindling, Neurologic; Phenytoin; Prodrugs; Rats; Rats, Wistar | 1998 |
Status epilepticus.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Child; Humans; Infusions, Intravenous; Lorazepam; Phenobarbital; Phenytoin; Status Epilepticus; United States | 1998 |
New dosage forms for old anticonvulsants.
Topics: Anticonvulsants; Diazepam; Dosage Forms; Humans; Phenytoin; Valproic Acid | 1998 |
Phenytoin blocks the reversal of a classically conditioned discriminative eyeblink response in rabbits.
Topics: Acoustic Stimulation; Animals; Auditory Perception; Blinking; Conditioning, Classical; Conditioning, Operant; Discrimination Learning; Hippocampus; Male; Phenytoin; Prodrugs; Rabbits; Rats; Reversal Learning | 1998 |
Cross-reactivity of fosphenytoin in two human plasma phenytoin immunoassays.
Topics: Anticonvulsants; Chromatography, High Pressure Liquid; Cross Reactions; Fluorescence Polarization Immunoassay; Humans; Immunoenzyme Techniques; Injections, Intraperitoneal; Injections, Intravenous; Models, Biological; Phenytoin; Predictive Value of Tests; Reproducibility of Results | 1998 |
Increased shelf-life of fosphenytoin: solubilization of a degradant, phenytoin, through complexation with (SBE)7m-beta-CD.
Topics: beta-Cyclodextrins; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Cyclodextrins; Drug Stability; Hydrogen-Ion Concentration; Kinetics; Phenytoin; Prodrugs; Solubility; Spectrophotometry, Ultraviolet; Temperature | 1998 |
Pharmacoeconomic considerations in treatment options for acute seizures.
Topics: Anticonvulsants; Child; Child, Preschool; Cost-Benefit Analysis; Diazepam; Economics, Pharmaceutical; Epilepsy; Humans; Infant; Infant, Newborn; Patient Education as Topic; Phenytoin; Seizures | 1998 |
A capillary GC-MS method for analysis of phenytoin and [13C3]-phenytoin from plasma obtained from pulse dose pharmacokinetic studies.
Topics: Animals; Anticonvulsants; Gas Chromatography-Mass Spectrometry; Humans; Infusions, Intravenous; Isotopes; Male; Molecular Structure; Phenytoin; Prodrugs; Rats; Rats, Sprague-Dawley; Reference Standards | 1998 |
Fosphenytoin in infants.
Topics: Anticonvulsants; Drug Therapy, Combination; Female; Humans; Hydrogen-Ion Concentration; Infant; Infant, Newborn; Male; Phenobarbital; Phenytoin; Prodrugs; Seizures | 1998 |
Elevated free fosphenytoin concentrations in uremic sera: uremic toxins hippuric acid and indoxyl sulfate do not account for the impaired protein binding of fosphenytoin.
Topics: Anticonvulsants; Drug Interactions; Fluorescence Polarization Immunoassay; Hippurates; Humans; Indican; Phenytoin; Protein Binding; Serum Albumin; Uremia | 1998 |
Phenytoin penetration into brain after administration of phenytoin or fosphenytoin.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Brain; Brain Chemistry; Dose-Response Relationship, Drug; Femoral Vein; Humans; Infusions, Intravenous; Injections, Intravenous; Male; Phenytoin; Rats; Rats, Sprague-Dawley | 1999 |
Probabilistic approach to the establishment of maximal content limits of impurities in drug formulations: the case of parenteral diphenylhydantoic acid.
Topics: Adolescent; Adult; Aged; Animals; Anticonvulsants; Cats; Dogs; Dose-Response Relationship, Drug; Drug Contamination; Female; Haplorhini; Humans; Infusions, Parenteral; Male; Maximum Allowable Concentration; Mice; Middle Aged; Monte Carlo Method; Phenytoin; Prodrugs; Rats; Rats, Wistar | 1999 |
From the Food and Drug Administration.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Arthritis; Celecoxib; Communicable Diseases; Cyclooxygenase Inhibitors; Drug Contamination; Drug Labeling; Humans; Phenytoin; Plasminogen Activators; Prodrugs; Pyrazoles; Sulfonamides; United States; United States Food and Drug Administration; Urokinase-Type Plasminogen Activator | 1999 |
Fosphenytoin for seizure control.
Topics: Adult; Anticonvulsants; Epilepsy, Tonic-Clonic; Female; Humans; Infusions, Intravenous; Male; Phenytoin; Prodrugs; Seizures; Therapeutic Equivalency | 1999 |
Use of alkaline phosphatase to correct the underestimation of fosphenytoin concentration in serum measured by phenytoin immunoassays.
Topics: Alkaline Phosphatase; Anticoagulants; Blood Specimen Collection; Citric Acid; Edetic Acid; False Negative Reactions; Fluorescence Polarization; Heparin; Humans; Immunoassay; Indicators and Reagents; Luminescent Measurements; Phenytoin | 1999 |
Fosphenytoin and status epilepticus.
Topics: Anticonvulsants; Humans; Infusions, Intravenous; Injections, Intramuscular; Phenytoin; Status Epilepticus | 1999 |
Phenytoin pharmacokinetics following oral administration of phenytoin suspension and fosphenytoin solution to rats.
Topics: Administration, Oral; Animals; Anticonvulsants; Male; Osmolar Concentration; Phenytoin; Rats; Rats, Wistar; Solutions; Suspensions; Time Factors | 1999 |
Falsely increased immunoassay measurements of total and unbound phenytoin in critically ill uremic patients receiving fosphenytoin.
Topics: Acute Kidney Injury; Anticonvulsants; Chromatography, High Pressure Liquid; Critical Illness; Cross Reactions; False Positive Reactions; Female; Humans; Immunoassay; Kidney Failure, Chronic; Male; Middle Aged; Phenytoin | 1999 |
Fosphenytoin reduces hippocampal neuronal damage in rat following transient global ischemia.
Topics: Analysis of Variance; Animals; Astrocytes; Cell Survival; Disease Models, Animal; Hippocampus; Ischemic Attack, Transient; Male; Neuroprotective Agents; Phenytoin; Prodrugs; Pyramidal Cells; Rats; Rats, Long-Evans | 1998 |
Phenytoin and fosphenytoin: a model of cost and clinical outcomes.
Topics: Anticonvulsants; Cost-Benefit Analysis; Drug Costs; Drug Therapy; Economics, Pharmaceutical; Humans; Nursing Staff, Hospital; Phenytoin; Surveys and Questionnaires | 1999 |
Fosphenytoin facts.
Topics: Anticonvulsants; Humans; Phenytoin; Seizures; Therapeutic Equivalency | 1999 |
Celebrex mix-up.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antidepressive Agents; Carrier Proteins; Celecoxib; Humans; Medication Errors; Names; Phenytoin; Pyrazoles; Receptors, Drug; Sulfonamides | 1999 |
Mathematical models to calculate fosphenytoin concentrations in the presence of phenytoin using phenytoin immunoassays and alkaline phosphatase.
Topics: Alkaline Phosphatase; Clinical Laboratory Techniques; Humans; Immunoassay; Luminescent Measurements; Models, Theoretical; Phenytoin; Prodrugs | 2000 |
Managing status epilepticus. New drug offers real advantages.
Topics: Anticonvulsants; Emergency Treatment; Humans; Phenytoin; Status Epilepticus | 2000 |
Anticonvulsant efficacy of topiramate in phenytoin-resistant kindled rats.
Topics: Amygdala; Animals; Anticonvulsants; Disease Models, Animal; Drug Resistance; Electric Stimulation; Epilepsy; Female; Fructose; Kindling, Neurologic; Phenytoin; Prodrugs; Rats; Rats, Wistar; Topiramate | 2000 |
Anticonvulsant efficacy of gabapentin and levetiracetam in phenytoin-resistant kindled rats.
Topics: Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Drug Evaluation; Drug Resistance; Female; Gabapentin; gamma-Aminobutyric Acid; Kindling, Neurologic; Levetiracetam; Phenytoin; Piracetam; Rats; Rats, Wistar; Seizures | 2000 |
Recovery of fosphenytoin injection after simulated nasogastric administration.
Topics: Anticonvulsants; Chromatography, High Pressure Liquid; Intubation, Gastrointestinal; Phenytoin; Syringes | 2000 |
[Prodilantin: a new antiepileptic?].
Topics: Anticonvulsants; Clinical Trials as Topic; Epilepsy; Humans; Phenytoin; Treatment Outcome | 2000 |
Cardiac arrest after fast intravenous infusion of phenytoin mistaken for fosphenytoin.
Topics: Adult; Anticonvulsants; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Costs; Female; Heart Arrest; Humans; Infusions, Intravenous; Medication Errors; Phenytoin; Status Epilepticus | 2001 |
[Acute poisoning with phenytoin caused by an error in the administration of fosphenytoin (Prodilantin)].
Topics: Aged; Anticonvulsants; Female; Humans; Medication Errors; Phenytoin | 2000 |
Fosphenytoin in infants of extremely low birth weight.
Topics: Anticonvulsants; Electroencephalography; Humans; Infant, Newborn; Infant, Very Low Birth Weight; Male; Phenytoin; Seizures | 2001 |
Prodrug metabolites: implications for therapeutic drug monitoring.
Topics: Chromatography, High Pressure Liquid; Drug Monitoring; False Positive Reactions; Humans; Immunoassay; Phenytoin; Prodrugs; Renal Insufficiency | 2001 |
Glucuronidation of prodrug reactive site: isolation and characterization of oxymethylglucuronide metabolite of fosphenytoin.
Topics: Chromatography, High Pressure Liquid; Deuterium; Fluorescence Polarization Immunoassay; Glucuronides; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Phenytoin; Prodrugs; Uremia | 2001 |
Fosphenytoin: an intravenous option for the management of acute trigeminal neuralgia crisis.
Topics: Acute Disease; Aged; Aged, 80 and over; Female; Humans; Injections, Intravenous; Male; Pain; Palliative Care; Phenytoin; Trigeminal Neuralgia | 2001 |
Inappropriate fosphenytoin use in the ED.
Topics: Administration, Oral; Adolescent; Adult; Anticonvulsants; Biological Availability; Consumer Product Safety; Cost-Benefit Analysis; Drug Costs; Drug Utilization Review; Emergency Service, Hospital; Female; Humans; Infusions, Intravenous; Male; Phenytoin; Prodrugs; Retrospective Studies; Seizures; United States | 2001 |
Rapid in vitro conversion of fosphenytoin into phenytoin in sera of patients with liver disease: role of alkaline phosphatase.
Topics: Alkaline Phosphatase; Anticonvulsants; Fluorescence Polarization Immunoassay; Humans; Liver Diseases; Metabolic Clearance Rate; Phenytoin | 2001 |
Subtherapeutic free phenytoin levels following fosphenytoin therapy in status epilepticus.
Topics: Anticonvulsants; Biotransformation; Child, Preschool; Humans; Male; Phenytoin; Status Epilepticus | 2002 |
Pharmacology advances in the neuroscience intensive care unit.
Topics: Anticonvulsants; Critical Care; Fibrinolytic Agents; Humans; Intensive Care Units; Neurosciences; Nursing Care; Phenytoin; Propofol; Seizures; Tissue Plasminogen Activator | 2002 |
Hypocalcemia-like electrocardiographic changes after administration of intravenous fosphenytoin.
Topics: Abdominal Pain; Adult; Anticonvulsants; Electroencephalography; Humans; Hypocalcemia; Infusions, Intravenous; Laparotomy; Male; Phenytoin; Prodrugs; Treatment Outcome | 2002 |
[Influence of modulatory activity of wound fluid on the characteristics of fibroblasts from irradiation and the action of phenytoin sodium].
Topics: Animals; Cell Division; Cobalt Radioisotopes; Collagen; Exudates and Transudates; Fibroblasts; Male; Phenytoin; Radiation Injuries, Experimental; Rats; Rats, Wistar; Whole-Body Irradiation; Wound Healing; Wounds and Injuries | 1999 |
Intravenous fosphenytoin in acute mania.
Topics: Acute Disease; Adult; Bipolar Disorder; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Male; Maximum Tolerated Dose; Middle Aged; Phenytoin; Prodrugs; Psychiatric Status Rating Scales | 2003 |
Absorption rate limit considerations for oral phosphate prodrugs.
Topics: Administration, Oral; Algorithms; Animals; Area Under Curve; Biological Transport, Active; Caco-2 Cells; Catechols; Chemical Phenomena; Chemistry, Physical; Humans; Hydrocortisone; Hydrogen-Ion Concentration; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Jejunum; Male; Nitriles; Perfusion; Permeability; Phenytoin; Prodrugs; Rats; Rats, Wistar; Tamoxifen | 2003 |
Pharmacokinetics and clinical effects of phenytoin and fosphenytoin in children with severe malaria and status epilepticus.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Female; Humans; Infant; Infusions, Intravenous; Malaria, Falciparum; Male; Phenytoin; Status Epilepticus | 2003 |
Enzyme-mediated precipitation of parent drugs from their phosphate prodrugs.
Topics: Alkaline Phosphatase; Caco-2 Cells; Chemical Precipitation; Chromatography, High Pressure Liquid; Crystallization; Drug Stability; Estramustine; Humans; Mass Spectrometry; Organophosphates; Phenytoin; Prodrugs; Solubility; Tamoxifen | 2003 |
A comparison of central brain (cerebrospinal and extracellular fluids) and peripheral blood kinetics of phenytoin after intravenous phenytoin and fosphenytoin.
Topics: Animals; Anticonvulsants; Brain; Extracellular Space; Frontal Lobe; Hippocampus; Injections, Intravenous; Male; Phenytoin; Prodrugs; Rats; Rats, Sprague-Dawley; Status Epilepticus; Time Factors | 2003 |
Cost-effectiveness of oral phenytoin, intravenous phenytoin, and intravenous fosphenytoin in the emergency department.
Topics: Administration, Oral; Anticonvulsants; Cost-Benefit Analysis; Decision Trees; Emergency Service, Hospital; Health Care Costs; Humans; Infusions, Intravenous; Length of Stay; Monte Carlo Method; Phenytoin; Seizures; Time and Motion Studies | 2004 |
Fosphenytoin farewell?
Topics: Administration, Oral; Anticonvulsants; Cost-Benefit Analysis; Emergency Service, Hospital; Health Care Costs; Humans; Infusions, Intravenous; Length of Stay; Phenytoin; Prodrugs; Seizures | 2004 |
Effects of fosphenytoin on nerve agent-induced status epilepticus.
Topics: Animals; Anticonvulsants; Atropine; Chemical Warfare Agents; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electroencephalography; Guinea Pigs; Injections, Intraperitoneal; Male; Phenytoin; Pralidoxime Compounds; Pyridostigmine Bromide; Soman; Status Epilepticus | 2004 |
Clinical policy: Critical issues in the evaluation and management of adult patients presenting to the emergency department with seizures.
Topics: Adult; Anticonvulsants; Electroencephalography; Emergency Service, Hospital; Epilepsy; Humans; Phenytoin; Secondary Prevention; Seizures; Status Epilepticus; Tomography, X-Ray Computed | 2004 |
Frontal lobe seizures and uveitis associated with acute human parvovirus B19 infection.
Topics: Acute Disease; Anti-Inflammatory Agents; Anticonvulsants; Brain; Carbamazepine; Child, Preschool; Electroencephalography; Erythema Infectiosum; Female; Frontal Lobe; Humans; Lamotrigine; Magnetic Resonance Imaging; Ophthalmic Solutions; Parvovirus B19, Human; Phenytoin; Polymerase Chain Reaction; Prednisone; Seizures; Triazines; Uveitis; Video Recording | 2004 |
Catheter occlusion from intravenous phenytoin.
Topics: Administration, Oral; Anticonvulsants; Catheterization, Central Venous; Humans; Infusions, Intravenous; Phenytoin; Seizures | 2004 |
Nurse sued when child dies from error in interpreting drug dosage.
Topics: Anticonvulsants; Cause of Death; Child; Drug Industry; Drug Labeling; Humans; Liability, Legal; Malpractice; Medication Errors; Nursing Staff, Hospital; Phenytoin; West Virginia | 2004 |
Hyperphosphatemia due to fosphenytoin in a pediatric ESRD patient.
Topics: Adolescent; Anticonvulsants; Epilepsy, Complex Partial; Humans; Kidney Failure, Chronic; Male; Phenytoin; Phosphates | 2005 |
Treatment delay and the risk of prolonged status epilepticus.
Topics: Administration, Rectal; Anticonvulsants; Benzodiazepines; Child, Preschool; Clinical Protocols; Disease Progression; Early Diagnosis; Epilepsy; Female; Humans; Infusion Pumps; Male; Phenobarbital; Phenytoin; Retrospective Studies; Secondary Prevention; Status Epilepticus; Thiopental; Time Factors; Treatment Outcome | 2005 |
Fosphenytoin may cause hemodynamically unstable bradydysrhythmias.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Anticonvulsants; Bradycardia; Child; Child, Preschool; Female; Hemodynamics; Humans; Infant; Infant, Newborn; Male; Middle Aged; Phenytoin; Status Epilepticus; United States; United States Food and Drug Administration | 2006 |
Interpretation of serum phenytoin concentrations: who would have thought that preventing and treating seizures were this challenging?
Topics: Anticonvulsants; Child; Humans; Infant; Intensive Care Units, Pediatric; Phenytoin; Protein Binding; Seizures | 2006 |
Rotavirus-induced seizures in childhood.
Topics: Anticonvulsants; Child, Preschool; Diarrhea; Enterovirus; Feces; Female; Follow-Up Studies; Humans; Infant; Lorazepam; Male; Phenytoin; Reverse Transcriptase Polymerase Chain Reaction; Rotavirus; Rotavirus Infections; Seizures; Severity of Illness Index; Vomiting | 2007 |
Resistance to antiepileptic drugs and expression of P-glycoprotein in two rat models of status epilepticus.
Topics: Amygdala; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; Diazepam; Disease Models, Animal; Drug Resistance; Electric Stimulation; Endothelium, Vascular; Female; Gene Expression Regulation; Genes, MDR; Hippocampus; Phenobarbital; Phenytoin; Pilocarpine; Quinolines; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2008 |
Fatal errors with cerebyx.
Topics: Adverse Drug Reaction Reporting Systems; Anticonvulsants; Chemistry, Pharmaceutical; Drug Dosage Calculations; Drug Information Services; Drug Labeling; Emergency Nursing; Humans; Medication Errors; Medication Systems, Hospital; Phenytoin; United States; United States Food and Drug Administration | 2008 |
FDA: Epilepsy drugs may carry skin risks for Asians.
Topics: Anticonvulsants; Asian People; Carbamazepine; HLA-B Antigens; Humans; Phenytoin; Risk; Skin Diseases; United States; United States Food and Drug Administration | 2008 |
Video recording devices as a diagnostic aid.
Topics: Adult; Anticonvulsants; Brain Neoplasms; Hemangioma, Cavernous, Central Nervous System; Humans; Magnetic Resonance Imaging; Male; Phenytoin; Seizures; Video Recording; Young Adult | 2011 |
Case 3-2009: a 9-month-old boy with seizures.
Topics: Anticonvulsants; Humans; Hypocalcemia; Infant; Male; Phenytoin; Seizures; Vitamin D; Vitamin D Deficiency | 2009 |
Evaluation of in vitro models for screening alkaline phosphatase-mediated bioconversion of phosphate ester prodrugs.
Topics: Alkaline Phosphatase; Animals; Caco-2 Cells; Drug Delivery Systems; Drug Stability; Fluconazole; Half-Life; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Intestines; Male; Mucous Membrane; Organophosphates; Phenytoin; Phosphates; Prodrugs; Rats; Rats, Sprague-Dawley; Solubility | 2009 |
Blood pressure changes after intravenous fosphenytoin and levetiracetam in patients with acute cerebral symptoms.
Topics: Adult; Aged; Aged, 80 and over; Blood Pressure; Chi-Square Distribution; Female; Humans; Hypotension; Levetiracetam; Male; Medical Records; Middle Aged; Patient Selection; Phenytoin; Piracetam; Regression Analysis; Retrospective Studies; Seizures; Treatment Outcome | 2009 |
Minimum requirements for approval of a drug in status epilepticus.
Topics: Anticonvulsants; Clinical Trials as Topic; Drug Approval; Europe; Humans; Phenytoin; Prodrugs; Research Design; Status Epilepticus; Treatment Outcome | 2009 |
Effect of an educational initiative on physicians' use of weight-based fosphenytoin loading doses in the emergency department.
Topics: Anticonvulsants; Education, Medical, Continuing; Emergency Service, Hospital; Guideline Adherence; Humans; Phenytoin; Practice Guidelines as Topic; Practice Patterns, Physicians' | 2010 |
Sporadic hemiplegic migraine and epilepsy associated with CACNA1A gene mutation.
Topics: Adult; Anticonvulsants; Calcium Channels; Chromosomes, Human, Pair 19; Epilepsy; Female; Humans; Injections, Intravenous; Migraine with Aura; Phenytoin; Point Mutation | 2010 |
Persistent focal seizures after cat scratch encephalopathy.
Topics: Acyclovir; Anti-Bacterial Agents; Anticonvulsants; Antiviral Agents; Cat-Scratch Disease; Ceftriaxone; Child; Drug Therapy, Combination; Electroencephalography; Epilepsy, Tonic-Clonic; Humans; Lorazepam; Male; Phenytoin; Status Epilepticus; Vancomycin | 2010 |
Evaluation of intramuscular fosphenytoin vs intravenous phenytoin loading in the ED.
Topics: Adult; Anticonvulsants; Chi-Square Distribution; Emergency Service, Hospital; Female; Humans; Injections, Intramuscular; Injections, Intravenous; Length of Stay; Male; Middle Aged; Phenytoin; Retrospective Studies; Seizures; Statistics, Nonparametric; Time Factors | 2011 |
Advisers recommend improved labeling for phenytoin, fosphenytoin.
Topics: Adult; Anticonvulsants; Child; Drug Labeling; Humans; Infant, Newborn; Phenytoin; Seizures; United States; United States Food and Drug Administration | 2010 |
Subacute encephalopathy and seizures in alcoholics (SESA) presenting with non-convulsive status epilepticus.
Topics: Acetamides; Alcohol Withdrawal Seizures; Alcoholism; Anticonvulsants; Brain Diseases; Confusion; Diffusion Magnetic Resonance Imaging; Electroencephalography; Female; Humans; Lacosamide; Lorazepam; Middle Aged; Neurologic Examination; Paresis; Patient Compliance; Phenytoin; Seizures; Status Epilepticus; Tomography, X-Ray Computed; Valproic Acid | 2011 |
Possible acute thrombocytopenia post esomeprazole and hydantoin coadministration.
Topics: Anticonvulsants; Blood Platelets; Esomeprazole; Humans; Male; Middle Aged; Phenytoin; Platelet Count; Proton Pump Inhibitors; Thrombocytopenia | 2010 |
Initial EEG predicts outcomes in a trial of levetiracetam vs. fosphenytoin for seizure prevention.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Brain Injuries; Disability Evaluation; Electroencephalography; Female; Glasgow Outcome Scale; Humans; Levetiracetam; Linear Models; Male; Middle Aged; Phenytoin; Piracetam; Randomized Controlled Trials as Topic; Seizures; Statistics, Nonparametric; Subarachnoid Hemorrhage; Young Adult | 2012 |
Levetiracetam for busulfan-induced seizure prophylaxis in children undergoing hematopoietic stem cell transplantation.
Topics: Adolescent; Adult; Anticonvulsants; Busulfan; Child; Child, Preschool; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Infant; Levetiracetam; Phenytoin; Piracetam; Seizures; Transplantation Conditioning; Young Adult | 2012 |
Population pharmacokinetics of phenytoin after intravenous administration of fosphenytoin sodium in pediatric patients, adult patients, and healthy volunteers.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Biotransformation; Child; Child, Preschool; Clinical Trials, Phase I as Topic; Clinical Trials, Phase III as Topic; Computer Simulation; Drug Dosage Calculations; Female; Humans; Infusions, Intravenous; Japan; Linear Models; Male; Middle Aged; Models, Biological; Phenytoin; Prodrugs; Randomized Controlled Trials as Topic; Retrospective Studies; Software; Young Adult | 2013 |
Treatment of status epilepticus: an international survey of experts.
Topics: Administration, Intravenous; Adult; Anticonvulsants; Child; Consensus; Expert Testimony; Humans; Hypnotics and Sedatives; Levetiracetam; Lorazepam; Midazolam; Pentobarbital; Phenytoin; Piracetam; Propofol; Societies, Medical; Status Epilepticus; Surveys and Questionnaires; Valproic Acid | 2013 |
How did phenobarbital's chemical structure affect the development of subsequent antiepileptic drugs (AEDs)?
Topics: Anticonvulsants; Carbamazepine; Drug Discovery; Epilepsy; Ethosuximide; History, 20th Century; Humans; Mephenytoin; Mephobarbital; Phenobarbital; Phenytoin; Primidone; Structure-Activity Relationship; Succinimides; Valproic Acid | 2012 |
Survey of prophylactic antiseizure drug use for non-traumatic intracerebral hemorrhage.
Topics: Anticonvulsants; Brain; Cerebral Hemorrhage; Drug Prescriptions; Drug Utilization; Electroencephalography; Humans; Levetiracetam; Phenytoin; Piracetam; Practice Patterns, Physicians'; Seizures; Surveys and Questionnaires | 2013 |
Status epilepticus in a child secondary to ingestion of skin-lightening cream.
Topics: Anticonvulsants; Ataxia; Eating; Emergencies; Humans; Hydroquinones; Infant; Intubation, Intratracheal; Lorazepam; Male; Phenobarbital; Phenytoin; Physical Therapy Modalities; Seizures; Skin Lightening Preparations; Status Epilepticus | 2013 |
Fosphenytoin induced transient pendular nystagmus.
Topics: Anticonvulsants; Brain; Epilepsy; Humans; Infusions, Intravenous; Magnetic Resonance Imaging; Male; Middle Aged; Neurologic Examination; Nystagmus, Pathologic; Patient Compliance; Phenytoin; Saccades | 2013 |
Treatment of Recurrent Electrographic Nonconvulsive Seizures (TRENdS) study.
Topics: Acetamides; Anticonvulsants; Electroencephalography; Humans; Lacosamide; Monitoring, Physiologic; Phenytoin; Retrospective Studies; Secondary Prevention; Status Epilepticus; Treatment Outcome | 2013 |
Levetiracetam versus (fos)phenytoin for seizure prophylaxis in pediatric patients with intracranial hemorrhage.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Female; Humans; Incidence; Infant; Intracranial Hemorrhages; Levetiracetam; Male; Phenytoin; Piracetam; Primary Prevention; Retrospective Studies; Seizures; Treatment Outcome | 2014 |
Could there be an alternative explanation for cardiomyopathy in an infant following fosphenytoin overdose?
Topics: Anticonvulsants; Cardiomyopathies; Drug Overdose; Humans; Infant; Phenytoin | 2014 |
Efficacy and safety of fosphenytoin for acute encephalopathy in children.
Topics: Acute Disease; Adolescent; Anticonvulsants; Brain Diseases; Child; Child, Preschool; Female; Humans; Infant; Male; Phenytoin; Retrospective Studies; Seizures; Treatment Outcome | 2015 |
Efficacy and safety of fosphenytoin for benign convulsions with mild gastroenteritis.
Topics: Administration, Intravenous; Anticonvulsants; Child, Preschool; Female; Gastroenteritis; Humans; Infant; Male; Phenytoin; Seizures; Treatment Outcome | 2015 |
Modeling early-onset post-ischemic seizures in aging mice.
Topics: Aging; Analysis of Variance; Animals; Anticonvulsants; Brain; Chi-Square Distribution; Disease Models, Animal; Electrocoagulation; Electroencephalography; Functional Laterality; Infarction, Middle Cerebral Artery; Lorazepam; Male; Mice; Mice, Inbred C57BL; Phenytoin; Seizures; Time Factors | 2015 |
Use of IV fosphenytoin pharmacokinetics to determine the loading dose for a clinical trial of canine status epilepticus.
Topics: Administration, Intravenous; Animals; Anticonvulsants; Area Under Curve; Dogs; Dose-Response Relationship, Drug; Female; Linear Models; Male; Phenytoin; Time Factors | 2015 |
The safety and efficacy of fosphenytoin for the treatment of status epilepticus.
Topics: Anticonvulsants; Humans; Phenytoin; Seizures; Status Epilepticus | 2015 |
Impact of Body Habitus on Phenytoin Levels Following Fosphenytoin Loading Dose in Pediatric Patients.
Topics: Adolescent; Anticonvulsants; Body Mass Index; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Linear Models; Male; Obesity; Overweight; Phenytoin; Retrospective Studies; Solubility; Thinness; Young Adult | 2015 |
Early-Onset Convulsive Seizures Induced by Brain Hypoxia-Ischemia in Aging Mice: Effects of Anticonvulsive Treatments.
Topics: Age of Onset; Aging; Animals; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; Hippocampus; Hypoxia-Ischemia, Brain; Injections, Intraperitoneal; Lorazepam; Male; Mice; Mice, Inbred C57BL; Phenytoin; Seizures | 2015 |
Development and application of an ex vivo fosphenytoin nasal bioconversion/permeability evaluation method.
Topics: Administration, Intranasal; Animals; Brain; Chemistry, Pharmaceutical; Drug Delivery Systems; Humans; Hydrophobic and Hydrophilic Interactions; Nasal Mucosa; Permeability; Phenytoin; Prodrugs; Solubility; Swine | 2016 |
Methylphenidate Overdose Causing Secondary Polydipsia and Severe Hyponatremia in an 8-Year-Old Boy.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Humans; Hyponatremia; Lisdexamfetamine Dimesylate; Male; Methylphenidate; Phenytoin; Polydipsia; Sodium Chloride; Treatment Outcome; Water Intoxication | 2017 |
Fosphenytoin-induced dyskinesias in an infant with Sturge-Weber syndrome.
Topics: Anticonvulsants; Dyskinesia, Drug-Induced; Electroencephalography; Female; Humans; Infant; Phenytoin; Sturge-Weber Syndrome; Ultrasonography; Videotape Recording | 2016 |
Variation in seizure prophylaxis in severe pediatric traumatic brain injury.
Topics: Age Factors; Anticonvulsants; Brain; Brain Injuries, Traumatic; Child; Electroencephalography; Female; Glasgow Coma Scale; Guidelines as Topic; Humans; Male; Phenytoin; Retrospective Studies; Seizures; Time Factors; Trauma Centers; United States | 2016 |
Levetiracetam Prophylaxis for Post-traumatic Brain Injury Seizures is Ineffective: A Propensity Score Analysis.
Topics: Adolescent; Adult; Anticonvulsants; Brain Injuries, Traumatic; Chemoprevention; Databases, Factual; Female; Humans; Levetiracetam; Male; Middle Aged; Phenytoin; Piracetam; Propensity Score; Retrospective Studies; Seizures; Treatment Failure; Young Adult | 2016 |
Maculopapular type drug eruption caused by fosphenytoin.
Topics: Aged, 80 and over; Anticonvulsants; Drug Eruptions; Female; Humans; Phenytoin | 2016 |
Incidence and risk factors of hypotension after intravenous fosphenytoin administration.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Blood Pressure; Female; Humans; Hypotension; Incidence; Infusions, Intravenous; Male; Middle Aged; Phenytoin; Retrospective Studies; Risk Factors | 2017 |
Simultaneous triple therapy for the treatment of status epilepticus.
Topics: Animals; Anticonvulsants; Brain Waves; Combined Modality Therapy; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electroencephalography; Male; Maze Learning; Midazolam; Neurons; Phenytoin; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus; Treatment Outcome; Valproic Acid | 2017 |
Efficacy of levetiracetam versus fosphenytoin for the recurrence of seizures after status epilepticus.
Topics: Administration, Intravenous; Administration, Oral; Anticonvulsants; Blood Pressure; Databases, Factual; Diazepam; Drug Substitution; Emergency Medical Services; Female; Hospitals, General; Humans; Japan; Levetiracetam; Male; Middle Aged; Phenytoin; Piracetam; Recurrence; Retrospective Studies; Seizures; Status Epilepticus; Treatment Outcome | 2017 |
Fosphenytoin-induced purple glove syndrome: A case report.
Topics: Aged; Anticonvulsants; Edema; Epilepsy; Humans; Male; Phenytoin; Skin Diseases; Upper Extremity | 2017 |
[Drugs news].
Topics: Adolescent; Adult; Age Factors; Amitriptyline; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Child; Drug Industry; Duodenal Ulcer; Female; France; Gastroesophageal Reflux; Humans; Male; Migraine Disorders; Pharmacovigilance; Phenytoin; Plasma Substitutes; Polygeline; Proton Pump Inhibitors; Randomized Controlled Trials as Topic; Risk Factors; Sex Factors; Stomach Ulcer; Topiramate | 2017 |
Fosphenytoin pre-medication for pediatric extra-operative electrical stimulation brain mapping.
Topics: Administration, Intravenous; Brain Mapping; Child; Drug Resistant Epilepsy; Electric Stimulation; Electrocorticography; Female; Humans; Language; Male; Phenytoin; Retrospective Studies; Seizures; Sodium Channel Blockers | 2018 |
Fosphenytoin for control of electrical storm in acute myocardial infarction and Purkinje fiber-mediated arrhythmias.
Topics: Aged; Aged, 80 and over; Arrhythmias, Cardiac; Female; Humans; Male; Middle Aged; Phenytoin; Purkinje Fibers; Sodium Channel Blockers; Tachycardia, Ventricular | 2018 |
Fosphenytoin Population Pharmacokinetics in the Acutely Ill Pediatric Population.
Topics: Acute Disease; Adolescent; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Evaluation; Drug Interactions; Emergency Service, Hospital; Female; Gestational Age; Humans; Infant; Infant, Newborn; Intensive Care Units, Pediatric; Male; Phenytoin; Retrospective Studies; Seizures; Sodium Channel Blockers | 2018 |
A cool side effect of valproic acid administration: Single dose-induced hypothermia.
Topics: Adult; Anticonvulsants; Humans; Hypothermia; Levetiracetam; Male; Phenytoin; Seizures; Valproic Acid | 2018 |
Fat, Pharmacokinetics, and Fosphenytoin: Bigger Doses May Be Better.
Topics: Anticonvulsants; Child; Humans; Phenytoin | 2018 |
Fosphenytoin vs. continuous midazolam for pediatric febrile status epilepticus.
Topics: Anticonvulsants; Child; Child, Preschool; Cohort Studies; Female; Humans; Infant; Male; Midazolam; Outcome Assessment, Health Care; Phenytoin; Seizures, Febrile; Status Epilepticus | 2018 |
A new method for simultaneous quantification of fosphenytoin, phenytoin and its primary metabolite 5-(4-hydroxyphenyl)-5-phenylhydantoin in whole blood by ultra-performance liquid chromatography-tandem mass spectrometry.
Topics: Acetonitriles; Animals; Biomarkers; Chromatography, High Pressure Liquid; Hydantoins; Liquid-Liquid Extraction; Male; Methanol; Phenytoin; Rats; Rats, Wistar; Tandem Mass Spectrometry | 2018 |
Evaluation of Intravenous Phenytoin and Fosphenytoin Loading Doses: Influence of Obesity and Sex.
Topics: Administration, Intravenous; Adult; Aged; Anticonvulsants; Body Mass Index; Dose-Response Relationship, Drug; Drug Dosage Calculations; Epilepsy; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Obesity; Phenytoin; Retrospective Studies; Sex Factors | 2019 |
European Academy of Neurology guideline on trigeminal neuralgia.
Topics: Analgesics; Carbamazepine; Decompression, Surgical; Europe; Gabapentin; Humans; Neurology; Oxcarbazepine; Phenytoin; Trigeminal Neuralgia | 2019 |
Population Pharmacokinetic Analysis of Phenytoin After Intravenous Administration of Fosphenytoin in Adult and Elderly Epileptic Patients.
Topics: Administration, Intravenous; Adult; Aged; Aged, 80 and over; Anticonvulsants; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Retrospective Studies; Young Adult | 2019 |
Nanoemulsions and thermosensitive nanoemulgels of phenytoin and fosphenytoin for intranasal administration: Formulation development and in vitro characterization.
Topics: Administration, Intranasal; Anticonvulsants; Drug Compounding; Drug Delivery Systems; Drug Liberation; Emulsions; Gels; Nanostructures; Phenytoin; Temperature | 2020 |
Evaluation of Fosphenytoin Therapeutic Drug Monitoring in the Neurocritical Care Unit.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Brain Injuries; Critical Care; Dose-Response Relationship, Drug; Drug Monitoring; Female; Humans; Intensive Care Units; Male; Middle Aged; Phenytoin; Retrospective Studies; Seizures; Young Adult | 2020 |
Infant with status epilepticus secondary to systemic lidocaine toxicity from topical application.
Topics: Administration, Topical; Anticonvulsants; Diagnosis, Differential; Female; Humans; Infant; Lidocaine; Lorazepam; Phenytoin; Status Epilepticus | 2020 |
Fosphenytoin in Status Epilepticus: The Ice Needs to be Broken.
Topics: Anticonvulsants; Child; Humans; Ice; Phenytoin; Status Epilepticus | 2020 |
Efficacy, Tolerability and Serum Phenytoin Levels after Intravenous Fosphenytoin Loading Dose in Children with Status Epilepticus.
Topics: Administration, Intravenous; Adolescent; Anticonvulsants; Biomarkers; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Infant; Linear Models; Male; Phenytoin; Prospective Studies; Status Epilepticus; Treatment Outcome | 2020 |
Second-line anticonvulsants for paediatric convulsive status epilepticus.
Topics: Anticonvulsants; Child; Double-Blind Method; Humans; Levetiracetam; Phenytoin; Status Epilepticus; Valproic Acid | 2020 |
Evaluation of fosphenytoin, levetiracetam, and propofol as treatments for nerve agent-induced seizures in pediatric and adult rats.
Topics: Age Factors; Animals; Anticonvulsants; Brain; Disease Models, Animal; Female; Levetiracetam; Male; Organothiophosphorus Compounds; Phenytoin; Propofol; Rats, Sprague-Dawley; Sarin; Sex Factors; Status Epilepticus | 2020 |
Levetiracetam for Benzodiazepine-Refractory Status Epilepticus.
Topics: Benzodiazepines; Humans; Levetiracetam; Phenytoin; Status Epilepticus; Treatment Outcome | 2020 |
Clinical Effectiveness of Levetiracetam Compared to Fosphenytoin in the Treatment of Benzodiazepine Refractory Convulsive Status Epilepticus: Correspondence.
Topics: Benzodiazepines; Humans; Levetiracetam; Phenytoin; Status Epilepticus; Treatment Outcome | 2021 |
Phenytoin versus fosphenytoin for second-line treatment of status epilepticus: propensity score matching analysis using a nationwide inpatient database.
Topics: Adult; Anticonvulsants; Humans; Inpatients; Phenytoin; Propensity Score; Status Epilepticus | 2020 |
Choosing Anticonvulsant Medications to Manage Status Epilepticus.
Topics: Adult; Anticonvulsants; Disease Management; Drug Therapy, Combination; Epilepsy, Generalized; Female; Humans; Levetiracetam; Midazolam; Phenytoin; Status Epilepticus; Valproic Acid | 2020 |
Antiepileptic combination therapy with Stevens-Johnson syndrome and toxic epidermal necrolysis: Analysis of a Japanese pharmacovigilance database.
Topics: Anticonvulsants; Carbamazepine; Clobazam; Clonazepam; Databases, Factual; Drug Therapy, Combination; Epilepsy; Gabapentin; Humans; Japan; Lacosamide; Lamotrigine; Levetiracetam; Lorazepam; Pharmacovigilance; Phenytoin; Stevens-Johnson Syndrome; Valproic Acid | 2020 |
Efficacy of Fosphenytoin as First-Line Antiseizure Medication for Neonatal Seizures Compared to Phenobarbital.
Topics: Anticonvulsants; Child, Preschool; Cohort Studies; Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Male; Phenobarbital; Phenytoin; Retrospective Studies; Seizures; Treatment Outcome | 2021 |
First-line medication dosing in pediatric refractory status epilepticus.
Topics: Adolescent; Age Factors; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Resistant Epilepsy; Female; Guideline Adherence; Humans; Infant; Levetiracetam; Male; Multivariate Analysis; Phenobarbital; Phenytoin; Practice Guidelines as Topic; Proportional Hazards Models; Retrospective Studies; Sex Factors; Status Epilepticus; Time-to-Treatment | 2020 |
Intranasal fosphenytoin: The promise of phosphate esters in nose-to-brain delivery of poorly soluble drugs.
Topics: Administration, Intranasal; Anticonvulsants; Brain; Esters; Phenytoin; Phosphates | 2021 |
Effect of therapeutic plasma exchange on phenytoin plasma concentration in patients receiving intravenous fosphenytoin therapy.
Topics: Administration, Intravenous; Adolescent; Anticonvulsants; Area Under Curve; Female; Humans; Phenytoin; Plasma Exchange | 2020 |
Clinically Mild Encephalitis/Encephalopathy with a Reversible Splenial Lesion Associated with Rhinovirus.
Topics: Anticonvulsants; Child, Preschool; Corpus Callosum; Encephalitis, Viral; Female; Humans; Midazolam; Phenytoin; Picornaviridae Infections; Rhinovirus; Spleen | 2021 |
Treatment of SCN4A-induced myotonic crisis.
Topics: Dantrolene; Diazepam; Humans; Male; Muscle Relaxants, Central; Myotonia; NAV1.4 Voltage-Gated Sodium Channel; Phenytoin; Sodium Channel Blockers; Young Adult | 2021 |
Levetiracetam compared with phenytoin or fosphenytoin in benzodiazepine-refractory pediatric status epilepticus.
Topics: Anticonvulsants; Benzodiazepines; Child; Humans; Levetiracetam; Phenytoin; Status Epilepticus | 2022 |
Nose-to-brain delivery of phenytoin and its hydrophilic prodrug fosphenytoin combined in a microemulsion - formulation development and in vivo pharmacokinetics.
Topics: Animals; Anticonvulsants; Brain; Mice; Phenytoin; Prodrugs | 2021 |
Intravenous fosphenytoin therapy for rescue of acute trigeminal neuralgia crisis in patients awaiting neurosurgical procedures: A cross-sectional study.
Topics: Aged; Anticonvulsants; Cross-Sectional Studies; Female; Humans; Phenytoin; Retrospective Studies; Trigeminal Neuralgia | 2021 |
Fosphenytoin Alleviates Herpes Simplex Virus Infection-Induced Provoked and Spontaneous Pain-Like Behaviors in Mice.
Topics: Animals; Herpes Simplex; Herpesvirus 1, Human; Hyperalgesia; Mice; Pain; Phenytoin | 2022 |
Intravenous fosphenytoin as treatment for acute exacerbation of trigeminal neuralgia: A prospective systematic study of 15 patients.
Topics: Follow-Up Studies; Humans; Phenytoin; Prospective Studies; Trigeminal Neuralgia | 2022 |
Efficacy of single dose of phenytoin/fosphenytoin in benign convulsions with mild gastroenteritis.
Topics: Child; Gastroenteritis; Humans; Infant; Phenytoin; Retrospective Studies; Seizures; Sodium | 2023 |