phenytoin has been researched along with folic acid in 227 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 180 (79.30) | 18.7374 |
| 1990's | 15 (6.61) | 18.2507 |
| 2000's | 10 (4.41) | 29.6817 |
| 2010's | 20 (8.81) | 24.3611 |
| 2020's | 2 (0.88) | 2.80 |
| Authors | Studies |
|---|---|
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Rosenberg, IH | 1 |
| Blair, JA; Lei, FH; Lucas, ML; Mangkornthong, P; Swanston, SK | 1 |
| Nuttall, FQ; Shafer, RB | 1 |
| Chokroverty, S; Sayeed, ZA | 1 |
| Behan, PO; Dick, H; Lambie, DG; Shakir, RA | 1 |
| Butterworth, CE; Fukushima, K; Fukushima, T; Krumdieck, CL; Shiota, T | 1 |
| Kelly, D; Reed, B; Scott, J; Weir, D | 1 |
| Cerda, JJ; Nelson, EW; Streiff, RR; Wilder, BJ | 1 |
| Ramsay, RE; Strauss, RG; Wilder, BJ; Willmore, LJ | 1 |
| Avogaro, A; Benetello, P; Dainese, R; Furlanut, M | 1 |
| Campbell, B; Foster, N | 1 |
| Knuutila, S; Tammisto, P; Tontti, K; Weber, TH | 1 |
| Bill, P; Buchanan, N; Eyberg, C; Fernandes Costa, F; Moodley, GP; Strickwold, B | 1 |
| Chanarin, I; Laundy, M; Reid, C; Reynolds, EH; Taguchi, H | 1 |
| DeVore, GR; Woodbury, DM | 1 |
| Aarli, JA | 2 |
| Saunders, J; Wickramasinghe, SN; Williams, G | 1 |
| Butterworth, CE; Ch'ien, LT; Krumdieck, CL; Scott, CW | 1 |
| Aderet, NB; Biale, Y; Lewenthal, H | 1 |
| Chen, CP; Wagner, C | 1 |
| Chadwick, D; Chanarin, I; Jenner, P; Reynolds, EH | 1 |
| Klein, SM | 1 |
| Beaver, WT; Bottomley, WK; Brown, RS | 1 |
| Beaver, WT; Bottomley, WK; Brown, RS; Di Stanislao, PT | 1 |
| Carl, GF; Eto, I; Furman, GM; Krumdieck, CL; Schatz, RA; Smith, ML | 1 |
| Collins, JF; Hassell, TM; Keeling, SD; Poppell, TD | 1 |
| Bunch, SE; Cullen, JM; Easley, JR | 1 |
| Gill, DS; Latham, J; Wickramasinghe, SN | 1 |
| Zhu, MX | 1 |
| Alfaro Giner, A; Antolín Rodríguez, MA; Peñarrocha Diago, M; Pérez Sirvent, ML | 1 |
| Zhang, C; Zhou, SS | 1 |
| Bäckman, N; Blomquist, HK; Hänström, L; Heijbel, J; Holm, AK; Säfström, G | 1 |
| Baker, M; Bissessar, A; Callaghan, N; Crowley, M; Goggin, T; Gough, H | 1 |
| Bailey, LB; Cerda, JJ; Collins, CS; Hillier, S; Wilder, BJ | 1 |
| Akinsete, I; Danesi, MA | 1 |
| Baker, H; Drew, HJ; Frank, O; Molofsky, W; Vogel, RI | 1 |
| Cowie, VA; Deb, S; Richens, A | 1 |
| Berg, MJ; Ebert, BE; Rivey, MP; Schottelius, DD | 1 |
| Billings, RE; Hansen, DK | 1 |
| Baumgardner, R; Blake, DA; Mellits, ED; Niebyl, JR; Rocco, LE | 1 |
| Boorman, GA; Hong, L; Luster, MI; Pung, O; Tucker, AN | 1 |
| Baylis, EM; Crowley, JM; Marks, V; Preece, JM; Sylvester, PE | 1 |
| Andreasen, PB; Hansen, JM; Siersbaek-Nielsen, K; Skovsted, L | 2 |
| Reynolds, EH | 4 |
| Bornstein, B; Don, R; Elian, M; Korczyn, AD | 1 |
| Duchen, L; Harris, R; Marsden, CD; Parsons, V; Reynolds, EH | 1 |
| Matthews, DM; Reynolds, EH | 1 |
| Chanarin, I; Matthews, DM; Reynolds, EH | 1 |
| Horwitz, SJ; Klipstein, FA; Lovelace, RE | 1 |
| Hoffbrand, AV; Necheles, TF | 1 |
| Castle, WB; Godwin, HA; Rosenberg, IH; Streiff, RR | 1 |
| Lehtovaara, R; Weckman, N | 1 |
| Baugh, CM; Krumdieck, CL | 1 |
| Viukari, NM | 2 |
| Fehling, C; Jägerstad, M; Lindstrand, K; Westesson, AK | 1 |
| Brubakk, O | 1 |
| Leary, PM | 1 |
| Himanen, P; Markkanen, T; Molnár, G; Pajula, RL | 1 |
| Bernstein, R; Strauss, RG | 1 |
| Elsborg, L | 2 |
| Mercier-Parot, L; Tuchmann-Duplessis, H | 1 |
| de Wolff, FA; Hillen, FC; Noach, EL; Sprangers, WJ | 1 |
| Taguchi, H | 2 |
| MacKinney, AA; Vas, R | 1 |
| Gardner, AJ | 1 |
| Eisen, AA; Sherwin, AL; Woods, JF | 1 |
| Arakawa, T; Honda, Y; Narisawa, K; Yoshida, T | 1 |
| Robenberg, IH | 1 |
| Fenton, GM; Laundy, M; Reynolds, EH; Slavin, BN | 1 |
| Arakawa, T; Honda, Y | 1 |
| Hilgartner, MW; Kutt, H; Solomon, GE | 1 |
| Arakawa, T; Honda, Y; Narisawa, K | 2 |
| Spector, RG | 1 |
| Jenkins, D; Spector, RG | 1 |
| Arakawa, T | 1 |
| Herbert, V | 1 |
| Gallagher, BB; Glass, D; Mattson, RH; Reynolds, EH | 1 |
| Zellweger, H | 1 |
| Adir, J; Barr, WH | 1 |
| Boyle, PH; Houlihan, CM; Scott, JM; Weir, DG | 1 |
| Bergström, K; Blomstrand, R; Jacobson, S | 1 |
| Chanarin, I; Perry, J | 1 |
| Dry, J; Perrault, M | 1 |
| Gallagher, BB; Mattson, RH; Reynolds, EH | 1 |
| Hara, K; Hasei, T; Hiraki, K; Iwasaki, I; Taguchi, H | 1 |
| Frenkel, EP; McCall, MS; Sheehan, RG | 1 |
| Herbert, V; Momtazi, S | 1 |
| Haghshenass, M; Rao, DB | 1 |
| Bhaktaviziam, A; Raman, PT; Taori, GM; Varkey, K | 1 |
| Himanen, P; Markkanen, T; Pajula, RL; Virtanen, S | 1 |
| Arakawa, T; Hirono, H; Honda, Y; Narisawa, K; Yoshida, T | 1 |
| Baxter, MG; Miller, AA; Webster, RA | 1 |
| Henriksen, O; Loyning, Y | 1 |
| Brown, JP; Davidson, GE; Scott, JM; Weir, DG | 1 |
| Lund, L; Reizenstein, P | 1 |
| Magnus, E | 1 |
| Heischkeil, R | 1 |
| Roberts, PJ | 1 |
| Arimura, GK; Blasquez, J; Halloran, M; Lutcher, CL; Yunis, AA | 1 |
| Jensen, ON; Olesen, OV | 4 |
| Bernstein, LH; Efron, G; Gutstein, S; Weiner, S | 1 |
| Bowe, JC; Cornish, EJ; Dawson, M | 1 |
| Ardeman, S; Hunter, J; Maxwell, JD; Stewart, DA; Williams, R | 1 |
| Kenyon, IE | 1 |
| Burns, DG; Spray, GH | 1 |
| Brown, N; Cohen, N; Gerson, CD; Hepner, GW; Herbert, V; Janowitz, HD | 1 |
| Ellegaard, J; Esmann, V | 1 |
| Kariks, J; Perry, SW; Wood, D | 1 |
| Moe, PJ; Wefring, KW | 1 |
| Johnson, AL; Preece, J; Reynolds, EH | 1 |
| Bracchetti, A; Giannì, E | 1 |
| Hommes, OR; Houben, PF; Knaven, PJ | 1 |
| Bertino, JR; Levitt, M; Nixon, PF; Pincus, JH | 1 |
| Das, KC; Hoffbrand, AV | 2 |
| Allen, CD | 1 |
| Bernstein, LH; Gutstein, S; Weiner, SV | 1 |
| Allen, CD; Klipstein, FA | 2 |
| Boykin, ME; Hooshmand, H | 1 |
| Benn, A; Blair, JA; Cooke, WT; Matty, AJ; Smith, ME; Swan, CH | 1 |
| Pritchard, JA; Scott, DE; Whalley, PJ | 1 |
| Richens, A; Waters, AH | 1 |
| Corcino, JJ; Herbert, V; Waxman, S | 1 |
| Miller, DR | 1 |
| Chanarin, I; Perry, J; Rothman, D; Ward, A | 1 |
| Gordon, N | 1 |
| Hepner, GW | 1 |
| Kutt, H; McDowell, FH; Winters, W | 1 |
| Dahlke, MB; Mertens-Roesler, E | 1 |
| Dyer, AM; Hill, R; Rowan, RM; Taylor, WO | 1 |
| Halsted, CH | 1 |
| Harrison, JV; Inoue, F | 1 |
| Halsted, CH; Reisenauer, AM | 1 |
| Hosokawa, K; Kugoh, T | 1 |
| Carl, GF; Smith, DB | 2 |
| Berg, MJ; Rivey, MP; Schottelius, DD | 1 |
| Billings, RE | 2 |
| Bardy, AH; Granström, ML; Hiilesmaa, VK; Teramo, K | 1 |
| Butlin, AT; Cook, ML; Danta, G | 1 |
| Chou, RC; Levy, G | 1 |
| Biale, Y; Lewenthal, H | 1 |
| Blair, JA; Guest, AE; Pheasant, AE; Saleh, AM | 1 |
| Berg, MJ; Fischer, LJ; Lantz, RK; Rivey, MP; Schottelius, DD; Vern, BA | 1 |
| Berg, MJ; Fischer, LJ; Rivey, MP; Schottelius, DD; Vern, BA | 1 |
| Inoue, F; Walsh, RJ | 1 |
| Cerda, JJ; Crick, WF; Nelson, EW; Streiff, RR; Wilder, BJ | 1 |
| Colman, N; Herbert, V; Hettiarachchy, N | 1 |
| Richens, A | 1 |
| Noach, EL; Telkers-Duijts, GA; van Rees, H | 1 |
| Boldarov, AI; Gvirtsman, LE; Maĭzelis, MIa; Vaĭntrub, MIa; Zabludovskiĭ, AL | 1 |
| Mallek, HM; Nakamoto, T | 1 |
| Kutt, H; Solomon, GE | 1 |
| Gibberd, FB; Nicholls, A; Wright, MG | 1 |
| Bachevalier, J; Botez, MI; Joyal, C; Maag, U | 1 |
| Ariel, M; Eilam, Y; Grossowicz, N; Jablonska, M | 1 |
| Evans, MA | 1 |
| Blair, JA; Lucas, ML; Swanston-Flatt, SK | 1 |
| Bailey, LB; Enneking-Ivey, O; Gawley, L; Hananian, J; Hurd, R | 1 |
| Bachevalier, J; Botez, MI | 1 |
| Berg, A; Lindbom, U; Sundqvist, A; Tomson, T | 1 |
| Berg, MJ; Chenard, CA; Fincham, RW; Schneider, PJ; Schottelius, DD; Stumbo, PJ | 1 |
| Seymour, RA | 1 |
| Botez, MI; Botez, T; Lalonde, R; Ross-Chouinard, A | 1 |
| Abramovitch, Y; Levkovitch, Y; Nizan, I | 1 |
| Drinka, PJ; Goodwin, JS; Langer, EH; Voeks, SK | 1 |
| Carl, GF; Hudson, FZ; McGuire, BS | 1 |
| Fiehn, W; Kohl, B; Rieser, PA; Ringleb, P; Schwaninger, M; Walter-Sack, I; Winter, R | 1 |
| Apeland, T; Kristensen, O; Mansoor, MA; Strandjord, RE | 1 |
| Doğan, A; Imirzalioğlu, N; Ozdemir, A; Sengül, A; Tunca, Y | 1 |
| Acar, O; Canbilen, A; Güney, O; Konak, A | 1 |
| CHALMERS, JN; HORSFIELD, GI | 1 |
| SPARBERG, M | 1 |
| KLIPSTEIN, FA | 1 |
| DEVOTO, RA; PODESTA, LD; PRECERUTTI, AS | 1 |
| ANAND, MP | 1 |
| HANSEN, HA; NORDQVIST, P; SOURANDER, P | 1 |
| DEVERDIER, CH; HAMFELT, A; KILLANDER, A; MALERS, E | 1 |
| Chawla, HS; Gauba, K; Goyal, A; Prasad, VN; Singhi, P | 1 |
| Cole, DE; Langman, LJ; Mamdani, MM; Ray, JG | 1 |
| Bentley, ML; Steinweg, DL | 1 |
| Coker, I; Karaguzel, O; Ozdamar, O; Sener, U; Topbas, M; Zorlu, Y | 1 |
| Chitsaz, A; Ghazvini, MR; Nezhad, VS; Yazdi, HR; Zare, M | 1 |
| Apeland, T; Frøyland, ES; Kristensen, O; Mansoor, MA; Strandjord, RE | 1 |
| Hanken, I; Sander, CA; Schimmer, M | 1 |
| Erickson, RP | 1 |
| Khanna, S; Pillai, KK; Vohora, D | 1 |
| Arya, R; Gulati, S; Kabra, M; Kalra, V; Sahu, JK | 1 |
| Chan, SH; Chang, CC; Chang, WN; Chen, SD; Chuang, HY; Chuang, YC; Huang, CR; Lin, TK; Lu, CH; Tan, TY | 1 |
| Aziz, A; Gupta, A; Rizvi, I; Srivastava, VK | 1 |
| Alexander, JM; Wilson, KL | 1 |
| Akpan, HD; Akpanabiatu, MI; Ekaidem, IS; Uboh, FE; Usoh, IF | 1 |
| AlJehani, YA | 1 |
| Huang, H; Wang, N; Yu, C; Zhou, H | 1 |
| Doğan, Z; Kamışlı, Ö; Soysal, H | 1 |
| Attri, SV; Chandrasekaran, S; Patil, S; Sahu, JK; Sankhyan, N; Singhi, P; Suthar, R; Tageja, M | 1 |
| Sharma, TK; Sitaraman, S; Vardey, SK | 1 |
| Aeschlimann, DP; Aeschlimann, PC; Dennis, GJ; Grünewald, RA; Hadjivassiliou, M; Hoggard, N; Howell, SJ; Reuber, M; Shanmugarajah, PD | 1 |
| Chen, S; Xia, Z; Xu, H; Xu, S; Xu, Y; Zhang, N | 1 |
| A S, R; Baishya, J; Jose, M; Keni, RR; Sankara Sarma, P; Thomas, SV | 1 |
| Kathiravan, M; Kavitha, S; Shanthi, R | 1 |
22 review(s) available for phenytoin and folic acid
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Absorption and malabsorption of folates.
Topics: Alcoholism; Animals; Bile; Biological Transport; Cats; Chickens; Depression, Chemical; Ethanol; Folic Acid; gamma-Glutamyl Hydrolase; Haplorhini; Humans; Intestinal Absorption; Intestinal Mucosa; Malabsorption Syndromes; Molecular Conformation; Molecular Weight; Phenytoin; Rats; Sulfasalazine | 1976 |
On the mechanism of drug-induced gingival hyperplasia.
Topics: Dental Plaque; Diltiazem; Epidermal Growth Factor; Fibroblasts; Folic Acid; Gingival Hyperplasia; Glycosaminoglycans; Humans; Immunoglobulin Isotypes; Microbial Collagenase; Nifedipine; Phenytoin | 1991 |
Immunoglobulins in epilepsy.
Topics: alpha-Fetoproteins; Anticonvulsants; Autoantibodies; Bacterial Infections; DNA; Dysgammaglobulinemia; Epilepsy; Folic Acid; Humans; IgA Deficiency; Immune System; Immunity, Innate; Immunoglobulin A; Immunoglobulin A, Secretory; Immunoglobulins; Phenytoin; T-Lymphocytes | 1985 |
Anticonvulsants, folic acid, and epilepsy.
Topics: Anemia, Macrocytic; Animals; Anticonvulsants; Blood-Brain Barrier; Chemical Phenomena; Chemistry; Epilepsies, Partial; Epilepsy; Folic Acid; Humans; Leucovorin; Mice; Phenobarbital; Phenytoin; Primidone; Rabbits; Rats; Seizures | 1973 |
[Disorders of folate metabolism--primary and secondary metabolic disorders].
Topics: Animals; Child; DNA; Folic Acid; Folic Acid Deficiency; Formamides; Histidine; Humans; Liver; Metabolism, Inborn Errors; Phenytoin; Purines; Rats; Riboflavin Deficiency; RNA; Transferases | 1972 |
The five possible causes of all nutrient deficiency: illustrated by deficiencies of vitamin B 12 and folic acid.
Topics: Bile; Biological Transport, Active; Enzymes; Folic Acid; Folic Acid Deficiency; Food Deprivation; Gastric Juice; Humans; Intestinal Absorption; Intestinal Diseases, Parasitic; Nutrition Disorders; Nutritional Requirements; Phenytoin; Polycythemia; Vitamin B 12; Vitamin B 12 Deficiency | 1972 |
Cerebrospinal folate levels in epileptics and their response to folate therapy.
Topics: Anticonvulsants; Blood-Brain Barrier; Clinical Trials as Topic; Epilepsy; Folic Acid; Folic Acid Deficiency; Humans; Phenobarbital; Phenytoin; Primidone; Seizures; Tetrahydrofolates; Vitamin B 12 | 1974 |
Anticonvulsants during pregnancy: a danger to the developing fetus?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Barbiturates; Blood Coagulation Disorders; Chromosome Aberrations; Chromosome Disorders; Female; Fetus; Folic Acid; Humans; Infant, Newborn; Phenytoin; Pregnancy; Pregnancy Complications; Primidone; Succinimides; Trimethadione; Vitamin K; Vitamin K Deficiency Bleeding | 1974 |
Evaluation of the clinical inequivalency of drug products of varying bioavailability.
Topics: Aluminum Hydroxide; Arrhythmias, Cardiac; Biopharmaceutics; Digoxin; Dose-Response Relationship, Drug; Drug Evaluation; Drug Interactions; Drug Therapy, Combination; Folic Acid; Half-Life; Humans; Intestinal Absorption; Phenytoin; Research Design; Tetracycline; Therapeutic Equivalency; Time Factors | 1974 |
Anticonvulsant therapy and serum folate.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Depression, Chemical; Epilepsy; Female; Folic Acid; Humans; Phenytoin; Pregnancy | 1969 |
The absorption and malabsorption of folic acid and its polyglutamates.
Topics: Animals; Bile Acids and Salts; Biological Transport; Contraceptives, Oral; Folic Acid; Folic Acid Antagonists; Gastric Mucosa; Glutamates; Humans; Intestinal Absorption; Intestinal Mucosa; Malabsorption Syndromes; Phenytoin; Sprue, Tropical; Sulfobromophthalein | 1970 |
Osteomalacia and anticonvulsant drugs.
Topics: Alkaline Phosphatase; Anticonvulsants; Calcium; Epilepsy; Folic Acid; Humans; Liver; Osteomalacia; Phenobarbital; Phenytoin; Primidone; Vitamin D | 1971 |
Intestinal absorption and malabsorption of folates.
Topics: Alcoholism; Biological Transport, Active; Celiac Disease; Folic Acid; Folic Acid Antagonists; gamma-Glutamyl Hydrolase; Humans; Hydrogen-Ion Concentration; Hydrolysis; Infusions, Parenteral; Intestinal Absorption; Jejunum; Phenytoin; Pteroylpolyglutamic Acids; Sulfasalazine | 1980 |
Phenytoin-folic acid: a review.
Topics: Folic Acid; Folic Acid Deficiency; Humans; Nervous System Diseases; Phenytoin; Tissue Distribution | 1984 |
Phenytoin: relevant side effects.
Topics: Animals; Blood Coagulation; Bone and Bones; Calcium; Connective Tissue Diseases; Drug Hypersensitivity; Enzyme Induction; Enzyme Inhibitors; Folic Acid; Humans; Hyperglycemia; Immunity; Phenytoin; Rats; Species Specificity; Thyroid Hormones; Vitamin D | 1980 |
Drug-induced gingival overgrowth.
Topics: Animals; Calcium Channel Blockers; Cyclosporine; Folic Acid; Gingiva; Humans; Phenytoin | 1993 |
DIAGNOSTICALLY CONFUSING COMPLICATIONS OF DIPHENYLHYDANTOIN THERAPY. A REVIEW.
Topics: Adrenal Insufficiency; Anemia; Anemia, Aplastic; Anemia, Macrocytic; Conjunctivitis; Electrocardiography; Folic Acid; Heart Failure; Hepatitis; Hypertrichosis; Hypopituitarism; Hypothalamus; Leukopenia; Lymph Nodes; Metabolism; Methemoglobinemia; Pharmacology; Phenytoin; Pulmonary Fibrosis; Thrombocytopenia; Thyroid Function Tests; Toxicology; Vitamin B 12 | 1963 |
Genes, environment, and orofacial clefting: N-acetyltransferase and folic acid.
Topics: 6-Aminonicotinamide; Animals; Arylamine N-Acetyltransferase; Cleft Lip; Cleft Palate; Disease Models, Animal; DNA Methylation; Folic Acid; Genetic Predisposition to Disease; Hydrocortisone; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Phenytoin; Polymerase Chain Reaction; Risk Factors | 2010 |
Seizures and intracranial hemorrhage.
Topics: Anticonvulsants; Carbamazepine; Congenital Abnormalities; Eclampsia; Epilepsy; Female; Folic Acid; Heparin; Humans; Infant, Newborn; Intracranial Hemorrhages; Lamotrigine; Monitoring, Physiologic; North America; Phenobarbital; Phenytoin; Pregnancy; Risk Factors; Seizures; Subarachnoid Hemorrhage; Triazines; Valproic Acid; Vitamin K | 2013 |
Effects of phenytoin and lamotrigine treatment on serum BDNF levels in offsprings of epileptic rats.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsy; Female; Folic Acid; Lamotrigine; Phenytoin; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Triazines | 2016 |
Effects of phenytoin on serum levels of homocysteine, vitamin B12, folate in patients with epilepsy: A systematic review and meta-analysis (PRISMA-compliant article).
Topics: Anticonvulsants; Epilepsy; Folic Acid; Homocysteine; Humans; Phenytoin; Research Design; Vitamin B 12 | 2019 |
20 trial(s) available for phenytoin and folic acid
| Article | Year |
|---|---|
Effect of diphenylhydantoin on the bioavailability of citrus folate.
Topics: Adult; Biological Transport; Citrus; Female; Folic Acid; Humans; Intestinal Absorption; Jejunum; Male; Phenytoin; Tetrahydrofolates; Water | 1978 |
The administration of folic acid to institutionalized epileptic adults with phenytoin-induced gingival hyperplasia. A double-blind, randomized, placebo-controlled, parallel study.
Topics: Adult; Dental Care for Disabled; Dental Plaque Index; Double-Blind Method; Epilepsy; Female; Folic Acid; Gingival Hyperplasia; Humans; Intellectual Disability; Male; Periodontal Index; Phenytoin | 1991 |
Effect of folic acid on recurrence of phenytoin-induced gingival overgrowth following gingivectomy.
Topics: Adult; Analysis of Variance; Dental Plaque Index; Female; Folic Acid; Gingival Hyperplasia; Gingivectomy; Humans; Male; Models, Dental; Periodontal Index; Phenytoin; Photography; Recurrence; Time Factors | 1991 |
Folate treatment of diphenylhydantoin-induced gingival hyperplasia.
Topics: Adolescent; Child; Epilepsy; Female; Folic Acid; Gingival Hyperplasia; Humans; Intellectual Disability; Male; Phenytoin; Random Allocation | 1989 |
Effect of folate on phenytoin hyperplasia.
Topics: Administration, Oral; Administration, Topical; Adolescent; Adult; Child; Clinical Trials as Topic; Double-Blind Method; Female; Folic Acid; Gingival Hyperplasia; Humans; Male; Phenytoin; Random Allocation; Tablets | 1987 |
Influence of folic acid on blood-phenytoin levels.
Topics: Adult; Anticonvulsants; Epilepsy; Folic Acid; Folic Acid Deficiency; Humans; Male; Phenobarbital; Phenytoin; Primidone | 1971 |
Relation of abnormal folate metabolism to neuropathy developing during anticonvulsant drug therapy.
Topics: Adolescent; Adult; Anticonvulsants; Biological Assay; Child; Electrodiagnosis; Electromyography; Epilepsy; Folic Acid; Humans; Lactobacillus; Middle Aged; Peripheral Nervous System Diseases; Phenytoin; Placebos | 1968 |
Impairment of intestinal deconjugation of dietary folate. A possible explanation of megaloblastic anaemia associated with phenytoin therapy.
Topics: Anemia, Macrocytic; Biological Assay; Folic Acid; Folic Acid Deficiency; Gastrointestinal Hormones; Glutamates; Humans; Intestinal Mucosa; Lactobacillus; Phenytoin; Seizures | 1968 |
Folate therapy in epilepsy. A controlled study.
Topics: Clinical Trials as Topic; Cognition; Epilepsy; Evaluation Studies as Topic; Folic Acid; Humans; Leucovorin; Personality; Phenobarbital; Phenytoin; Primidone; Psychological Tests | 1973 |
Cerebrospinal folate levels in epileptics and their response to folate therapy.
Topics: Anticonvulsants; Blood-Brain Barrier; Clinical Trials as Topic; Epilepsy; Folic Acid; Folic Acid Deficiency; Humans; Phenobarbital; Phenytoin; Primidone; Seizures; Tetrahydrofolates; Vitamin B 12 | 1974 |
The effect of phenytoin on the absorption of synthetic folic acid polyglutamate.
Topics: Adult; Biological Assay; Folic Acid; Glutamates; Humans; Intestinal Absorption; Lacticaseibacillus casei; Phenytoin | 1972 |
Subnormal serum folate due to anticonvulsive therapy. A double-blind study of the effect of folic acid treatment in patients with drug-induced subnormal serum folates.
Topics: Adult; Anticonvulsants; Clinical Trials as Topic; Epilepsy; Erythrocyte Count; Female; Folic Acid; Hematocrit; Hemoglobinometry; Humans; Male; Phenobarbital; Phenytoin; Placebos; Primidone | 1970 |
Evaluation of folic acid supplements in children taking phenytoin.
Topics: Adolescent; Child; Child Behavior Disorders; Clinical Trials as Topic; Electroencephalography; Epilepsy; Female; Folic Acid; Folic Acid Deficiency; Gingival Hyperplasia; Hemoglobins; Humans; Male; Phenytoin; Placebos; Seizures | 1971 |
Folate status and requirement in pregnancy.
Topics: Abortion, Spontaneous; Anemia, Macrocytic; Birth Weight; Diet; Female; Folic Acid; Folic Acid Deficiency; Hemoglobinometry; Humans; Iron; Phenytoin; Pregnancy; Pregnancy Complications, Hematologic; Seasons | 1968 |
The influence of folic acid on the frequency of epileptic attacks.
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Epilepsy; Female; Folic Acid; Humans; Male; Phenytoin; Placebos | 1981 |
Folic acid improves phenytoin pharmacokinetics.
Topics: Adult; Cross-Over Studies; Drug Interactions; Female; Folic Acid; Food-Drug Interactions; Humans; Phenytoin | 1995 |
Thiamine and folate treatment of chronic epileptic patients: a controlled study with the Wechsler IQ scale.
Topics: Adult; Brain; Double-Blind Method; Drug Therapy, Combination; Education; Electroencephalography; Epilepsy; Female; Folic Acid; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Thiamine; Vitamin B 12; Wechsler Scales | 1993 |
Folic acid and phenytoin induced gingival overgrowth--is there a preventive effect.
Topics: Adolescent; Anticonvulsants; Child; Dental Plaque; Epilepsy; Folic Acid; Follow-Up Studies; Gingival Overgrowth; Gingivitis; Hematinics; Humans; Oral Hygiene; Phenytoin | 2004 |
Ineffectiveness of folic acid supplementation against phenytoin-induced decrease in salivary immunoglobulin A concentration of epileptic patients.
Topics: Dietary Supplements; Epilepsy; Female; Folic Acid; Humans; IgA Deficiency; Male; Middle Aged; Phenytoin; Saliva; Treatment Outcome | 2008 |
Folic acid supplementation prevents phenytoin-induced gingival overgrowth in children.
Topics: Adolescent; Anticonvulsants; Child; Double-Blind Method; Female; Folic Acid; Gingival Hyperplasia; Humans; Male; Phenytoin; Risk Reduction Behavior; Time Factors; Treatment Outcome; Vitamin B Complex | 2011 |
186 other study(ies) available for phenytoin and folic acid
| Article | Year |
|---|---|
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Effect of ethanol, diphenylhydantoin, methotrexate and low sodium ion concentration on jejunal surface pH and folic acid transfer in the rat [proceedings].
Topics: Animals; Biological Transport; Ethanol; Folic Acid; Hydrogen-Ion Concentration; Intestinal Mucosa; Jejunum; Methotrexate; Phenytoin; Rats; Sodium | 1978 |
Calcium and folic acid absorption in patients taking anticonvulsant drugs.
Topics: Adult; Aged; Calcium; Cholecalciferol; Epilepsy; Folic Acid; Humans; Male; Middle Aged; Osteomalacia; Phenobarbital; Phenytoin; Rickets; Time Factors | 1975 |
Motor nerve conduction study in patients on diphenylhydantoin therapy.
Topics: Adolescent; Adult; Epilepsy; Folic Acid; Humans; Male; Middle Aged; Motor Neurons; Neural Conduction; Peripheral Nervous System Diseases; Phenytoin; Time Factors; Vitamin B 12 | 1975 |
Metabolism of immunoglobulin A, lymphocyte function, and histocompatibility antigens in patients on anticonvulsants.
Topics: Adolescent; Adult; Aged; Blood Proteins; Epilepsy; Female; Folic Acid; HLA Antigens; Humans; Immunologic Deficiency Syndromes; Lectins; Lymphocytes; Male; Middle Aged; Phenytoin; T-Lymphocytes | 1978 |
A long-term study of the excretion of folate and pterins in a human subject after ingestion of 14C folic acid, with observations on the effect of diphenylhydantoin administration.
Topics: Adult; Biological Assay; Eukaryota; Feces; Female; Folic Acid; Humans; Lacticaseibacillus casei; Phenytoin; Pterins; Urination | 1978 |
Effect of anticonvulsant drugs on the rate of folate catabolism in mice.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Female; Folic Acid; Male; Mice; Phenobarbital; Phenytoin; Pteroylpolyglutamic Acids | 1979 |
Hematologic effects of phenytoin therapy during pregnancy.
Topics: Carotenoids; Epilepsy; Female; Folic Acid; Folic Acid Deficiency; Hematologic Tests; Humans; Phenytoin; Pregnancy; Pregnancy Complications; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Seizures; Xylose | 1978 |
Effects of folic acid on phenytoin kinetics in healthy subjects.
Topics: Adult; Female; Folic Acid; Half-Life; Humans; Hydroxylation; Kinetics; Male; Phenytoin | 1978 |
The effect of diphenylhydantoin on the microbial assay of serum folate.
Topics: Biological Assay; Folic Acid; Humans; Lacticaseibacillus casei; Methods; Phenytoin | 1976 |
Long-term of phenytoin: Effects on whole blood and red cell folate and haematological parameters.
Topics: Adolescent; Adult; Anemia, Megaloblastic; Child; Child, Preschool; Epilepsy; Erythrocyte Count; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Hemoglobins; Humans; Male; Middle Aged; Phenytoin; Time Factors | 1977 |
Serum levels of anticonvulsants and haematological sequelae in black epileptics.
Topics: Adolescent; Adult; Aged; Black People; Child; Child, Preschool; Drug Combinations; Epilepsy; Erythrocytes; Female; Folic Acid; Humans; Male; Middle Aged; Patient Compliance; Phenobarbital; Phenytoin; Primidone | 1977 |
The effect of anticonvulsant drugs on thymidine and deoxyribosenucleic acid synthesis by human marrow cells.
Topics: Anticonvulsants; Bone Marrow; Bone Marrow Cells; Deoxyuridine; DNA; Folic Acid; Humans; Phenytoin; Thymidine; Vitamin B 12 | 1977 |
Phenytoin: an evaluation of several potential teratogenic mechanisms.
Topics: Animals; Cerebellum; Cerebral Cortex; Cytochrome P-450 Enzyme System; Female; Fetal Blood; Fetus; Folic Acid; Liver; Microsomes, Liver; Phenytoin; Placenta; Pregnancy; Pregnancy, Animal; Rats; Seizures | 1977 |
Changes in serum immunoglobulin levels during phenytoin treatment of epilepsy.
Topics: Adolescent; Adult; Child; Depression, Chemical; Epilepsy; Erythrocytes; Female; Folic Acid; Humans; Immunoglobulin A; Immunoglobulin E; Immunoglobulin G; Immunoglobulin M; Immunoglobulins; Male; Phenytoin; Vitamin B 12 | 1976 |
Effects of anticonvulsant drugs on the synthesis of DNA and protein by human bone marrow cells in vitro.
Topics: Bone Marrow; Bone Marrow Cells; DNA; Folic Acid; Humans; Leucine; Leucovorin; Phenobarbital; Phenytoin; Protein Biosynthesis; Thymidine | 1976 |
Harmful effect of megadoses of vitamins: electroencephalogram abnormalities and seizures induced by intravenous folate in drug-treated epileptics.
Topics: Adolescent; Adult; Aged; Child; Electroencephalography; Epilepsy; Female; Folic Acid; Humans; Male; Middle Aged; Phenytoin; Seizures | 1975 |
Congenital malformations due to anticonvulsive drugs.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anencephaly; Anticonvulsants; Birth Order; Cleft Lip; Cleft Palate; Epilepsy; Female; Fetal Death; Folic Acid; Folic Acid Antagonists; Hemorrhage; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications; Primidone; Trimethadione | 1975 |
Folate transport in the choroid plexus.
Topics: Animals; Biological Transport; Choroid Plexus; Dinitrophenols; Folic Acid; In Vitro Techniques; Kinetics; Oxygen; Phenobarbital; Phenytoin; Probenecid; Sodium; Swine; Tetrahydrofolates | 1975 |
Folate and monoamine metabolism in epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Biogenic Amines; Epilepsy; Erythrocytes; Folic Acid; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Middle Aged; Phenobarbital; Phenytoin; Primidone; Vitamin B 12 | 1975 |
Letter: Dilantin therapy.
Topics: Female; Folic Acid; Humans; Hypoxia; Phenytoin; Pregnancy | 1976 |
Phenytoin treatment and folate supplementation affect folate concentrations and methylation capacity in rats.
Topics: Animals; Brain; Drug Interactions; Folic Acid; Liver; Male; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Phenytoin; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Weight Gain | 1991 |
Hematologic values and plasma and tissue folate concentrations in dogs given phenytoin on a long-term basis.
Topics: Animals; Blood Cell Count; Dog Diseases; Dogs; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Neutropenia; Phenytoin; Radioimmunoassay; Thrombocytopenia; Time Factors | 1990 |
Effects of phenytoin sodium on doubling time, deoxyuridine suppression, 3H-methotrexate uptake and 57Co-cyanocobalamin uptake in HL60 cells.
Topics: Cell Division; Cell Survival; Cobalt Radioisotopes; Deoxyuridine; Folic Acid; Humans; Methotrexate; Phenytoin; Tritium; Tumor Cells, Cultured; Vitamin B 12 | 1990 |
[Effect of diphenylhydantoin sodium in causing deformity and that of folic acid preparations for its prevention].
Topics: Abnormalities, Drug-Induced; Animals; Female; Folic Acid; Phenytoin; Pregnancy; Rats; Rats, Inbred Strains | 1990 |
[Hematologic alterations and reduction in serum folate in epileptics treated with anticonvulsants].
Topics: Adolescent; Adult; Aged; Anticonvulsants; Blood Cell Count; Blood Cells; Child; Child, Preschool; Folic Acid; Hemoglobins; Humans; Middle Aged; Phenytoin; Prospective Studies | 1989 |
[Preventive effects of fortified pollen on diphenylhydantoin teratogenesis].
Topics: Abnormalities, Drug-Induced; Animals; Drug Synergism; Female; Folic Acid; Phenytoin; Pollen; Pregnancy; Rats; Rats, Inbred Strains | 1989 |
A comparative study of the relative effects of anticonvulsant drugs and dietary folate on the red cell folate status of patients with epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Diet; Drug Therapy, Combination; Epilepsy; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Humans; Male; Phenytoin; Valproic Acid | 1987 |
Red blood cell uptake of supplemental folate in patients on anticonvulsant drug therapy.
Topics: Adult; Anticonvulsants; Erythrocytes; Folic Acid; Food, Fortified; Humans; Male; Phenobarbital; Phenytoin | 1988 |
Long-term use of phenytoin: effect on haematological parameters in Nigerian epileptics.
Topics: Adolescent; Adult; Child; Epilepsy; Erythrocyte Indices; Female; Folic Acid; Hematocrit; Hematologic Tests; Hemoglobins; Humans; Male; Middle Aged; Nigeria; Phenytoin; Prospective Studies | 1988 |
Folate metabolism and problem behaviour in mentally handicapped epileptics.
Topics: Adolescent; Adult; Aged; Epilepsy; Female; Folic Acid; Humans; Intellectual Disability; Male; Mental Disorders; Middle Aged; Phenytoin; Vitamin B 12 | 1987 |
Utilization of Km for phenytoin dosage after folate addition to patient regimen.
Topics: Adult; Aged; Epilepsy; Folic Acid; Humans; Male; Middle Aged; Phenytoin | 1987 |
Phenytoin teratogenicity and effects on embryonic and maternal folate metabolism [published errtum appears in Teratology 1986 Dec;34(3):487].
Topics: Abnormalities, Drug-Induced; Animals; Embryo Implantation; Female; Folic Acid; Litter Size; Liver; Maternal-Fetal Exchange; Mice; Phenytoin; Pregnancy | 1985 |
Lack of maternal metabolic, endocrine, and environmental influences in the etiology of cleft lip with or without cleft palate.
Topics: Adult; Cleft Lip; Cleft Palate; Drug Interactions; Endocrine Glands; Erythrocytes; Female; Folic Acid; Humans; Kinetics; Maternal-Fetal Exchange; Phenytoin; Pregnancy; Prenatal Exposure Delayed Effects; Retrospective Studies; Risk | 1985 |
Alteration of bone marrow cell cycle kinetics by diphenylhydantoin: relationship to folate utilization and immune function.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Cell Cycle; Female; Folic Acid; Hematopoietic Stem Cells; Immunity; In Vitro Techniques; Malaria; Mice; Mice, Inbred Strains; Phenytoin; Thymidine; Tritium | 1985 |
Folic acid and phenytoin metabolism.
Topics: Arteriosclerosis; Biotransformation; Folic Acid; Humans; Microsomes, Liver; Phenytoin | 1971 |
Phenytoin and folate deficiency: failure to show dose dependency.
Topics: Epilepsy; Folic Acid; Folic Acid Deficiency; Humans; Phenytoin; Time Factors | 1974 |
Myopathy associated with anticonvulsant osteomalacia.
Topics: Adult; Anticonvulsants; Back Pain; Depression; Electroencephalography; Electromyography; Ergocalciferols; Female; Folic Acid; Hemoglobins; Humans; Intelligence; Microscopy, Electron; Muscular Diseases; Osteomalacia; Paralysis; Phenobarbital; Phenytoin; Thiazines; Vitamin D | 1973 |
Gastrointestinal function in anticonvulsant megaloblastic anaemia.
Topics: Adult; Anemia, Macrocytic; Epilepsy; Female; Folic Acid; Humans; Intestinal Absorption; Phenobarbital; Phenytoin; Primidone; Vitamin B 12 | 1966 |
Effects of folic acid on the mental state and fit-frequency of drug-treated epileptic patients.
Topics: Adolescent; Adult; Epilepsy; Female; Folic Acid; Folic Acid Deficiency; Follow-Up Studies; Humans; Male; Mental Health; Middle Aged; Phenobarbital; Phenytoin; Primidone | 1967 |
Neuropsychiatric aspects of anticonvulsant megaloblastic anaemia.
Topics: Acetazolamide; Adult; Anemia, Macrocytic; Epilepsy; Female; Folic Acid; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Primidone; Psychophysiologic Disorders; Thiazines; Vitamin B 12 | 1968 |
Mechanism of folate deficiency in patients receiving phenytoin.
Topics: Aged; Biological Assay; Dietary Proteins; Female; Folic Acid; Folic Acid Deficiency; Gastrointestinal Hormones; Glutamates; Humans; Intestinal Mucosa; Lactobacillus; Male; Middle Aged; Phenytoin; Protease Inhibitors | 1968 |
Folic acid and anticonvulsants.
Topics: Anticonvulsants; Epilepsy; Folic Acid; Humans; Nervous System Diseases; Phenytoin | 1969 |
Effects of phenytoin on folic-acid conjugases in man.
Topics: Acetone; Brain; Folic Acid; Glutamates; Humans; Intestinal Absorption; Intestines; Liver; Peptide Hydrolases; Phenytoin | 1969 |
Phenytoin, folates, and A.T.P.ase.
Topics: Adenosine Triphosphatases; Folic Acid; Folic Acid Deficiency; Humans; Phenytoin | 1970 |
The effect of anticonvulsant therapy upon the absorption of folates.
Topics: Adult; Aged; Anticonvulsants; Biological Assay; Epilepsy; Folic Acid; Folic Acid Deficiency; Humans; Intestinal Absorption; Lacticaseibacillus casei; Male; Middle Aged; Phenobarbital; Phenytoin; Primidone | 1973 |
[Phenytoin-induced folic acid deficiency].
Topics: Adult; Aged; Anemia, Macrocytic; Epilepsy; Epilepsy, Post-Traumatic; Female; Folic Acid; Folic Acid Deficiency; Humans; Middle Aged; Phenytoin | 1973 |
Folate studies in underprivileged children with epilepsy.
Topics: Anticonvulsants; Biological Assay; Child; Child, Preschool; Epilepsy; Euglena; Folic Acid; Hematocrit; Hemoglobins; Humans; Lacticaseibacillus casei; Leukocyte Count; Phenobarbital; Phenytoin; Primidone; Vitamin B 12 | 1973 |
Binding of folic acid to serum proteins. II. The effect of diphenylhydantoin treatment and of various diseases.
Topics: Adolescent; Adult; Aged; Blood Proteins; Chromatography, Ion Exchange; Dextrans; Epilepsy; Fatty Acids, Nonesterified; Female; Folic Acid; Hepatitis A; Humans; Hyperthyroidism; Macroglobulins; Male; Middle Aged; Multiple Myeloma; Phenytoin; Protein Binding; Transferrin | 1973 |
Folic acid and dilantin antagonism in pregnancy.
Topics: Adult; Chromatography, Gas; Drug Antagonism; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Female; Folic Acid; Humans; Phenytoin; Pregnancy; Pregnancy Complications | 1974 |
Inhibition of intestinal absorption of folic acid by phenytoin.
Topics: Adult; Aged; Epilepsy; Female; Folic Acid; Folic Acid Deficiency; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Jejunum; Middle Aged; Phenytoin; Tritium | 1974 |
The dysmorphogenic potential of phenytoin: experimental observations.
Topics: Abnormalities, Drug-Induced; Animals; Epilepsy; Female; Fetus; Folic Acid; Folic Acid Deficiency; Haplorhini; Humans; Mice; Phenytoin; Pregnancy; Pregnancy Complications; Rats; Teratogens | 1974 |
The influence of folic acid on the action of diphenylhydantoin.
Topics: Adenosine Triphosphatases; Animals; Biological Transport, Active; Cerebral Cortex; Drug Antagonism; Electroshock; Folic Acid; Intestinal Mucosa; Phenytoin; Potassium; Rats; Sodium | 1971 |
Clinical and experimental studies on folic acid deficiency due to anticonvulsants. I. Clinical and nutritional study on megalobastic anemia due to anticonvulsants.
Topics: Adult; Anemia, Macrocytic; Anticonvulsants; Diet; Epilepsy, Temporal Lobe; Folic Acid; Folic Acid Deficiency; Food Analysis; Humans; Male; Phenobarbital; Phenytoin | 1971 |
Clinical and experimental studies on folic acid deficiency due to anticonvulsants. 2. Investigations on patients receiving anticonvulsants and experimental study on the effect of diphenylhydantoin on the absorption of folic acid in rats.
Topics: Adolescent; Adult; Animals; Anticonvulsants; Cell Nucleus; Depression, Chemical; Epithelial Cells; Female; Folic Acid; Folic Acid Deficiency; Humans; Intestinal Absorption; Intestine, Small; Iron; Kidney; Leukocyte Count; Liver; Male; Middle Aged; Mouth Mucosa; Neutrophils; Phenobarbital; Phenytoin; Primidone; Rats; Tritium; Vitamin B 12 | 1971 |
The assay of diphenylhydantoin effects on growing human lymphocytes.
Topics: Adenosine Triphosphatases; Animals; Anticonvulsants; Carbon Isotopes; DNA; Folic Acid; Folic Acid Antagonists; Growth; Humans; Leucine; Leukocytes; Lymphocytes; Phenytoin; Phosphorus Isotopes; Potassium; Sodium; Thymidine; Tritium | 1973 |
Neuropathy after alcohol withdrawal.
Topics: Adult; Alcoholism; Female; Folic Acid; Humans; Male; Middle Aged; Peripheral Nervous System Diseases; Phenytoin; Substance Withdrawal Syndrome; Vitamin B 12; Vitamin B Complex | 1972 |
Peripheral nerve function in long-term therapy with diphenylhydantoin. A clinical and electrophysiologic correlation.
Topics: Adult; Aged; Carbamazepine; Electric Stimulation; Electromyography; Epilepsy; Ethosuximide; Evoked Potentials; Female; Folic Acid; Humans; Male; Median Nerve; Middle Aged; Neural Conduction; Peripheral Nerves; Peripheral Nervous System Diseases; Peroneal Nerve; Phenobarbital; Phenytoin; Primidone; Reaction Time; Reflex, Monosynaptic; Sural Nerve; Time Factors; Vitamin B 12 | 1974 |
Iatrogenic disorders in epilepsy.
Topics: Adrenal Insufficiency; Anemia, Macrocytic; Animals; Anticonvulsants; Cats; Cerebellar Diseases; Drug Therapy, Combination; Epilepsy; Folic Acid; Folic Acid Deficiency; Humans; Hypothyroidism; Metabolic Diseases; Peripheral Nervous System Diseases; Phenobarbital; Phenytoin; Rats; Rickets; Seizures | 1970 |
In vitro inhibition study of diphenylhydantoin upon rat liver enzymes in folic acid metabolism.
Topics: Amidohydrolases; Animals; Folic Acid; Glutamate-Ammonia Ligase; In Vitro Techniques; Liver; Lyases; Mannitol Dehydrogenases; Methyltransferases; Phenytoin; Rats | 1972 |
Drugs and folic acid absorption.
Topics: Animals; Contraceptives, Oral; Folic Acid; Folic Acid Deficiency; Intestinal Absorption; Methotrexate; Phenytoin; Pyrimethamine; Sulfasalazine; Trimethoprim | 1972 |
Serum immunoglobulins in epilepsy.
Topics: Adult; Drug Therapy, Combination; Epilepsy; Erythrocytes; Female; Folic Acid; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Male; Phenobarbital; Phenytoin; Primidone | 1974 |
Folic acid polyglutamate conjugase activity in liver of rats receiving diphenylhydantoin.
Topics: Administration, Oral; Animals; Carbon Radioisotopes; Carboxypeptidases; Folic Acid; Glutamates; Liver; Male; Phenytoin; Rats | 1974 |
Phenobarbital-induced coagulation defects in cats.
Topics: Alanine Transaminase; Animals; Animals, Newborn; Blood Coagulation; Blood Coagulation Disorders; Cats; Depression, Chemical; Dose-Response Relationship, Drug; Drug Interactions; Factor V Deficiency; Factor VII; Factor VII Deficiency; Female; Folic Acid; Hemophilia A; Hypoprothrombinemias; Liver; Maternal-Fetal Exchange; Phenobarbital; Phenytoin; Pregnancy; Primidone; Rats; Vitamin K | 1974 |
Decreased hepatic histidase activity induced by diphenylhydantoin administration as a cause of decrease in urinary formiminoglutamic acid in rats.
Topics: Alcohol Oxidoreductases; Ammonia-Lyases; Animals; Azo Compounds; FIGLU Test; Folic Acid; Glutarates; Injections, Intraperitoneal; Ligases; Liver; Male; Oxidoreductases; Phenytoin; Rats; Tetrahydrofolate Dehydrogenase; Transferases | 1973 |
Influence of folic acid on excitable tissues.
Topics: Animals; Behavior, Animal; Blood Pressure; Brain; Exploratory Behavior; Female; Folic Acid; Heart; Heart Rate; Ileum; In Vitro Techniques; Kidney; Leucovorin; Mice; Motor Activity; Muscle Contraction; Myocardium; Norepinephrine; Phenytoin; Pulse; Rats; Uterus | 1972 |
The actions of folate and phenytoin on the rat heart in vivo and in vitro.
Topics: Animals; Blood Pressure; Calcium Chloride; Folic Acid; Heart; Heart Rate; In Vitro Techniques; Leucovorin; Phenytoin; Rats; Time Factors | 1973 |
Long-term complete intravenous nutrition in man.
Topics: Adipose Tissue; Adult; Amino Acids; Anemia, Macrocytic; Body Weight; Carbohydrates; Cholesterol; Electrolytes; Emulsions; Fats; Female; Folic Acid; Humans; Linoleic Acids; Liver; Nitrogen; Nutritional Physiological Phenomena; Parenteral Nutrition; Phenytoin; Thrombophlebitis; Time Factors; Trace Elements; Vitamins; Water | 1972 |
Observations on folate absorption with particular reference to folate polyglutamate and possible inhibitors to its absorption.
Topics: Anemia, Pernicious; Biological Assay; Chlorides; Copper; Enterococcus faecalis; Folic Acid; Glutamates; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Intestine, Small; Lacticaseibacillus casei; Phenytoin; Protease Inhibitors; Silver Nitrate; Sulfobromophthalein | 1972 |
[Hydantoins today].
Topics: Arrhythmias, Cardiac; Carbohydrate Metabolism; Central Nervous System; Diabetic Neuropathies; Epilepsy; Folic Acid; Folic Acid Deficiency; Hypoglycemia; Insulin; Insulin Secretion; Obesity; Osteomalacia; Phenytoin; RNA | 1972 |
Clinical conference: megaloblastic anemia associated with anticonvulsant drugs.
Topics: Adult; Anemia, Macrocytic; Anticonvulsants; Female; Folic Acid; Folic Acid Deficiency; Humans; Phenobarbital; Phenytoin; Primidone | 1972 |
Relationships between serum and cerebrospinal fluid anticonvulsant drug and folic acid concentrations in epileptic patients.
Topics: Adult; Chromatography, Gas; Epilepsy; Female; Folic Acid; Humans; Male; Phenobarbital; Phenytoin; Primidone | 1972 |
[Nutritional and experimental studies on folic acid deficiency due to anticonvulsants].
Topics: Adult; Anemia, Macrocytic; Animals; Anticonvulsants; Diet; Epilepsy; Folic Acid; Folic Acid Deficiency; Humans; Intestinal Absorption; Intestine, Small; Male; Phenytoin; Rats; Tritium | 1972 |
Cerebrospinal fluid folate, and vitamin B 12 in anticonvulsant-induced megaloblastosis.
Topics: Aged; Alcoholism; Anemia, Macrocytic; Anemia, Pernicious; Female; Folic Acid; Hematocrit; Hemoglobins; Humans; Male; Middle Aged; Phenytoin; Reticulocytes; Vitamin B 12 | 1973 |
Intestinal absorption using vibration-obtained individual small bowel epithelial cells of the rat: folate absorption.
Topics: Animals; Epithelial Cells; Epithelium; Folic Acid; Glucose; Hydrogen-Ion Concentration; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Leucine; Male; Methods; Phenytoin; Rats; Tritium; Vibration | 1973 |
Serum folate levels during anticonvulsant therapy with diphenylhydantoin.
Topics: Adult; Age Factors; Aged; Binding Sites; Chronic Disease; Erythrocytes, Abnormal; Folic Acid; Hematocrit; Hemoglobinometry; Humans; Iron; Middle Aged; Phenytoin; Seizures | 1973 |
Osteomalacia due to phenytoin sodium. A case report with review of literature.
Topics: Adult; Bone and Bones; Calcium; Carbamazepine; Clavicle; Deficiency Diseases; Female; Folic Acid; Humans; Osteomalacia; Pelvis; Phenytoin; Radiography; Seizures; Spine; Vitamin D; Vitamin D Deficiency | 1973 |
Serum folic acid activity (L. casei) in Sephadex gel chromatography.
Topics: Albumins; Anemia, Pernicious; Chromatography; Dextrans; Female; Folic Acid; Humans; Macroglobulins; Phenytoin; Pregnancy; Protein Binding; Transferrin; Vitamin B 12 | 1973 |
Effect of diphenylhydantoin therapy on folate metabolism of mentally retarded epileptics.
Topics: Adolescent; Adult; Anticonvulsants; Azo Compounds; Child; Epilepsy; Female; FIGLU Test; Folic Acid; Glutarates; Histidine; Humans; Intellectual Disability; Male; Neutrophils; Phenytoin; Vitamin B 12 | 1973 |
Some studies on the convulsant action of folic acid.
Topics: Alkaloids; Animals; Auditory Threshold; Cerebral Ventricles; Dioxoles; Electroshock; Folic Acid; Folic Acid Antagonists; Glutamates; Injections; Injections, Intravenous; Isoquinolines; Mice; Ouabain; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Seizures; Strychnine | 1973 |
[Editorial: Antiepileptic agents--folic acid].
Topics: Anemia, Macrocytic; Epilepsy; Folic Acid; Folic Acid Deficiency; Humans; Phenobarbital; Phenytoin; Primidone; Vitamin B 12 | 1973 |
Effect of diphenylhydantoin and ethanol feeding on the synthesis of rat liver folates from exogenous pteroylglutamate (3H).
Topics: Animals; Chromatography, DEAE-Cellulose; Ethanol; Folic Acid; Liver; Phenytoin; Rats; Tritium | 1973 |
Effect of anticonvulsive drugs on folate absorption and the cerebrospinal folate pump.
Topics: Adolescent; Adult; Aged; Carbamazepine; Depression, Chemical; Epilepsy; Female; Folic Acid; Folic Acid Deficiency; Humans; Intestinal Absorption; Male; Methods; Middle Aged; Phenytoin; Trigeminal Neuralgia | 1973 |
[Folic acid and folate values in plasma and whole blood].
Topics: Acute Disease; Barbiturates; Contraceptives, Oral; Epilepsy; Ethanol; Female; Folic Acid; Folic Acid Deficiency; Hepatitis; Humans; Phenytoin; Pregnancy; Vitamin B 12 Deficiency | 1973 |
[Antimetabolites of folic acid metabolism with chemotherapeutic activity against rodent malaria (Plasmodium vinckei)].
Topics: Aminopterin; Animals; Cycloheximide; Female; Folic Acid; Folic Acid Antagonists; Hydantoins; Malaria; Male; Methotrexate; Mice; Mice, Inbred Strains; Phenobarbital; Phenytoin; Plasmodium; Primidone; Pyrimethamine; Thalidomide; Triamterene | 1973 |
Mechanism of decrease in serum folate levels of rats receiving diphenylhydantoin.
Topics: Animals; Blood Proteins; Folic Acid; Liver; Male; Methionine; Methyltransferases; Phenytoin; Protein Binding; Rats; Tetrahydrofolates; Vitamin B 12 | 1973 |
Inhibition of high-affinity glial uptake of 14C-glutamate by folate.
Topics: Animals; Carbon Radioisotopes; Epilepsy; Extracellular Space; Folic Acid; Ganglia, Spinal; Glutamates; Kinetics; Methotrexate; Neuroglia; Phenytoin; Pteridines; Rats | 1974 |
Biochemical lesion in Dilantin-induced erythroid aplasia.
Topics: Adolescent; Autoradiography; Bone Marrow; Bone Marrow Cells; Bone Marrow Diseases; Carbon Isotopes; DNA; Erythrocytes; Fluorescent Antibody Technique; Folic Acid; Formates; Glycine; Humans; In Vitro Techniques; Injections, Intravenous; Iron Isotopes; Male; Nucleosides; Phenytoin; Riboflavin; RNA; Tritium; Vitamin B 12 | 1967 |
Folate deficiency after anticonvulsant drugs: an effect of hepatic enzyme induction?
Topics: Adipates; Adolescent; Anticonvulsants; Child; Enzyme Induction; Epilepsy; Female; Folic Acid; Folic Acid Deficiency; Humans; Hydroxylation; Male; Microsomes, Liver; Phenytoin | 1972 |
Unplanned pregnancy in an epileptic.
Topics: Amenorrhea; Contraceptives, Oral; Epilepsy; Ethinyl Estradiol; Female; Folic Acid; Gluconates; Humans; Norethindrone; Phenytoin; Pregnancy | 1972 |
Folate deficiency and anticonvulsant drugs.
Topics: Animals; Enzyme Induction; Female; Folic Acid; Folic Acid Deficiency; Liver; Male; Oxidoreductases; Phenobarbital; Phenytoin; Rats; Transferases | 1972 |
Inhibition by diphenylhydantoin of folic acid absorption in man.
Topics: Depression, Chemical; Folic Acid; Humans; Intestinal Absorption; Jejunum; Methods; Perfusion; Phenytoin; Sodium; Tritium; Water | 1972 |
Folate deficiency in malnutrition, malabsorption, and during phenytoin treatment diagnosed by determination of serine synthesis in lymphocytes.
Topics: Adult; Aged; Anemia; Carbon Isotopes; Epilepsy; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Humans; Lymphocytes; Malabsorption Syndromes; Male; Methionine; Middle Aged; Nutrition Disorders; Phenytoin; Proteins; RNA; Serine; Time Factors | 1972 |
Adverse effects of hydantoins.
Topics: Ataxia; Drug Hypersensitivity; Folic Acid; Humans; Neurologic Manifestations; Phenytoin; Skin Manifestations | 1971 |
Serum folic acid and phenytoin levels in permanently hospitalized epileptic patients receiving anticonvulsant drug therapy.
Topics: Central Nervous System Diseases; Epilepsy; Folic Acid; Folic Acid Deficiency; Hospitalization; Humans; Phenytoin | 1971 |
Drugs and folic acid utilization.
Topics: Anemia, Macrocytic; Contraceptives, Oral; Female; Folic Acid; Folic Acid Deficiency; Glutamates; Humans; Intestinal Absorption; Phenytoin; Pregnancy; Progesterone; Tetrahydrofolate Dehydrogenase | 1971 |
[Megaloblastic anemia in children].
Topics: Adolescent; Anemia, Macrocytic; Blood Transfusion; Child; Female; Folic Acid; Humans; Intellectual Disability; Phenytoin; Vitamin B 12 | 1971 |
Folic acid concentrations in cerebrospinal fluid in relation to anticonvulsant drugs and cerebral atrophy.
Topics: Adult; Anticonvulsants; Atrophy; Brain Diseases; Epilepsy; Female; Folic Acid; Humans; Male; Mental Disorders; Middle Aged; Phenobarbital; Phenytoin; Pneumoencephalography | 1971 |
Folate metabolism in epileptic and psychiatric patients.
Topics: Adult; Antidepressive Agents; Epilepsy; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Humans; Male; Mental Disorders; Middle Aged; Phenobarbital; Phenothiazines; Phenytoin; Vitamin B 12 | 1971 |
[Contribution to the pathogenesis of gingival hypertrophy due to diphenylhydantoin in experiments on animals].
Topics: Anemia; Animals; Drug Synergism; FIGLU Test; Folic Acid; Gingival Hypertrophy; Phenobarbital; Phenytoin; Rats | 1968 |
Anticonvulsant drugs and folic acid in young mentally retarded epileptic patients. A study of serum folate, fit frequency and I.Q.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Epilepsy; Ethosuximide; Female; Folic Acid; Humans; Intellectual Disability; Intelligence Tests; Male; Phenobarbital; Phenytoin; Primidone; Prognosis | 1971 |
Transport characteristics of folates in cerebrospinal fluid; a study utilizing doubly labeled 5-methyltetrahydrofolate and 5-formyltetrahydrofolate.
Topics: Anemia, Macrocytic; Animals; Biological Transport; Blood-Brain Barrier; Carbon Isotopes; Chromatography, Gel; Dogs; Female; Folic Acid; Kinetics; Leucovorin; Male; Phenytoin; Tritium | 1971 |
Folate uptake by lymphocytes.
Topics: Carbon Isotopes; DNA; Folic Acid; In Vitro Techniques; Lectins; Lymphocyte Activation; Lymphocytes; Phenytoin; RNA; Tritium | 1969 |
Studies of folate uptake by phytohaemagglutinin-stimulated lymphocytes.
Topics: Adult; Anemia, Macrocytic; Anemia, Pernicious; Autoradiography; Biological Transport, Active; Carbon Isotopes; Cell Division; Culture Techniques; Dactinomycin; Folic Acid; Humans; Kinetics; Lectins; Lymphocyte Activation; Lymphocytes; Methotrexate; Phenytoin; RNA; Stimulation, Chemical; Temperature; Tritium | 1970 |
Folate and vitamin B12 in epilepsy.
Topics: Animals; Brain Chemistry; Cats; Epilepsy; Folic Acid; Folic Acid Deficiency; Humans; Phenytoin; Rats | 1970 |
Gamma glutamyl carboxypeptidase (conjugase), the folic acid-releasing enzyme of intestinal mucosa.
Topics: Animals; Bile Acids and Salts; Buffers; Carboxypeptidases; Celiac Disease; Folic Acid; Folic Acid Deficiency; Guinea Pigs; Humans; Hydrogen-Ion Concentration; Intestinal Mucosa; Malabsorption Syndromes; Phenytoin; Sulfobromophthalein | 1970 |
Phenytoin, folate, vitamin B12, and cyanide.
Topics: Cyanides; Folic Acid; Humans; Hydroxocobalamin; Phenytoin | 1970 |
Brain folate and diphenylhydantoin (DPH) concentrations in ataxic cats receiving DPH.
Topics: Animals; Ataxia; Brain; Cats; Folic Acid; Liver; Phenytoin | 1970 |
CSF and serum folic acid and protein changes with diphenylhydantoin treatment: laboratory and clinical correlations.
Topics: Aged; Blood Proteins; Cerebrospinal Fluid Proteins; Electroencephalography; Folic Acid; Folic Acid Deficiency; Humans; Middle Aged; Phenytoin; Potassium; Seizures; Sodium; Vitamin B 12 | 1970 |
Brain folate concentration in folate-deficient rats receiving diphenylhydantoin.
Topics: Animals; Brain; Brain Chemistry; Erythrocytes; Folic Acid; Folic Acid Deficiency; Intestinal Mucosa; Intestines; Liver; Phenytoin; Rats | 1970 |
The influence of folic acid on phenytoin (DPH) metabolism and the 24-hours fluctuation in urinary output of 5-(p-hydroxyphenyl)-5 phenyl-hydantoin (HPPH).
Topics: Adult; Female; Folic Acid; Humans; Hydantoins; Male; Phenytoin | 1970 |
Effect of intraluminal pH on the absorption of pteroylmonoglutamic acid.
Topics: Bicarbonates; Epilepsy; Female; Folic Acid; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Jejunum; Male; Phenytoin; Sodium | 1971 |
Maternal folate deficiency and pregnancy wastage. IV. Effects of folic acid supplements, anticonvulsants, and oral contraceptives.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Anemia, Macrocytic; Anemia, Sickle Cell; Anemia, Sideroblastic; Anticonvulsants; Birth Weight; Contraceptives, Oral; Drug Antagonism; Epilepsy; Female; Fetus; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Hemoglobinometry; Humans; Hypertension; Infant Mortality; Infant, Newborn; Infant, Premature; Iron; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications | 1971 |
Acute effect of phenytoin on serum folate concentration.
Topics: Folic Acid; Humans; Phenytoin; Time Factors | 1971 |
Jejunal pH and folic acid.
Topics: Barbiturates; Epilepsy; Folic Acid; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Jejunum; Phenytoin | 1971 |
Folic acid and the half-life of diphenylhydantoin in man.
Topics: Carbon Isotopes; Female; Folic Acid; Folic Acid Deficiency; Half-Life; Humans; Kidney Diseases; Liver; Liver Diseases; Phenytoin; Time Factors | 1971 |
Uptake of tritiated folates by human bone marrow cells in vitro.
Topics: Bone Marrow; Bone Marrow Cells; Chloromercuribenzoates; Folic Acid; Hematocrit; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Methotrexate; Phenytoin; Reticulocytes; Sulfhydryl Compounds; Tritium | 1971 |
Serum folate deficiency in children receiving anticonvulsant therapy.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Child; Child, Preschool; Epilepsy; Erythrocyte Count; Folic Acid; Folic Acid Deficiency; Hematocrit; Hemoglobinometry; Humans; Phenobarbital; Phenytoin | 1968 |
Folic acid deficiency from anticonvulsant therapy.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Folic Acid; Folic Acid Deficiency; Humans; Infant; Male; Mental Processes; Phenobarbital; Phenytoin; Primidone; Protein Biosynthesis | 1968 |
Mental effects of anticonvulsants, and folic acid metabolism.
Topics: Age Factors; Anemia, Macrocytic; Anticonvulsants; Brain; Epilepsy; Female; Folic Acid; Folic Acid Deficiency; Humans; Intellectual Disability; Male; Mental Disorders; Peripheral Nerves; Phenobarbital; Phenytoin; Primidone; Psychotic Disorders; Sex Factors; Spinal Cord; Vitamin B 12 | 1968 |
The absorption of pteroylglutamic (folic) acid in rats.
Topics: Animals; Folic Acid; Ileum; Intestinal Absorption; Intestine, Small; Jejunum; Methotrexate; Phenytoin; Rats; Tritium; Xylose | 1969 |
Folic acid and anticonvulsive drugs.
Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Erythrocyte Count; Female; FIGLU Test; Folic Acid; Folic Acid Deficiency; Hematocrit; Humans; Male; Middle Aged; Neutrophils; Phenobarbital; Phenytoin; Primidone; Psychotic Disorders; Vitamin B 12 | 1969 |
Depression of prahydroxylation of diphenylhydantoin by antituberculosis chemotherapy.
Topics: Adolescent; Adult; Aged; Aminosalicylic Acids; Anticonvulsants; Ataxia; Cycloserine; Drug Incompatibility; Drug Tolerance; Epilepsy; Female; Folic Acid; Humans; Isoniazid; Male; Middle Aged; Nystagmus, Pathologic; Phenytoin; Tuberculosis | 1966 |
Malabsorption of folic acid due to diphenylhydantoin.
Topics: Anemia, Macrocytic; Animals; Body Fluids; Child; Erythrocytes; Folic Acid; Folic Acid Deficiency; Humans; Inhalation; Lactobacillus; Malabsorption Syndromes; Middle Aged; Pancreas; Phenytoin; Poultry; Secretin | 1967 |
Case of tuberous sclerosis and haemorrhagic retinopathy (with fundus photographs).
Topics: Adult; Amphetamine; Anemia, Macrocytic; Female; Folic Acid; Fundus Oculi; Humans; Phenobarbital; Phenytoin; Photography; Retinal Hemorrhage; Seizures; Tuberous Sclerosis | 1967 |
Folic acid and phenytoin hyperplasia.
Topics: Adult; Female; Folic Acid; Gingival Hyperplasia; Humans; Male; Phenytoin | 1981 |
Human jejunal brush border folate conjugase. Characteristics and inhibition by salicylazosulfapyridine.
Topics: Carboxypeptidases; Cell Membrane; Ethanol; Folic Acid; gamma-Glutamyl Hydrolase; Humans; Jejunum; Kinetics; Microvilli; Phenytoin; Pteroylpolyglutamic Acids; Sulfasalazine | 1981 |
Pharmacodynamic factors in the occurrence of psychiatric symptoms among patients with epilepsy.
Topics: Anticonvulsants; Barbiturates; Carbamazepine; Epilepsy; Folic Acid; Humans; Kinetics; Mental Disorders; Phenobarbital; Phenytoin; Primidone; Valproic Acid; Vitamin B 12 | 1983 |
The effect of chronic phenytoin treatment on tissue folate concentrations and on the activities of the methyl synthetic enzymes in the rat.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; 5,10-Methylenetetrahydrofolate Reductase (FADH2); Alcohol Oxidoreductases; Animals; Brain; Folic Acid; Glycine Hydroxymethyltransferase; Liver; Male; Methionine Adenosyltransferase; Methyltransferases; Phenytoin; Rats; Rats, Inbred Strains; Time Factors; Transferases | 1983 |
Decreased hepatic 5, 10-methylenetetrahydrofolate reductase activity in mice after chronic phenytoin treatment.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Alcohol Oxidoreductases; Animals; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Folic Acid; Kinetics; Liver; Mice; Phenytoin | 1984 |
Serum folate concentrations during pregnancy in women with epilepsy: relation to antiepileptic drug concentrations, number of seizures, and fetal outcome.
Topics: Carbamazepine; Congenital Abnormalities; Epilepsy; Female; Fetal Death; Folic Acid; Humans; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications | 1983 |
Anticonvulsants, folic acid and memory dysfunction in epileptics.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Erythrocytes; Folic Acid; Humans; Memory Disorders; Middle Aged; Phenytoin; Valproic Acid | 1984 |
Effect of folic acid on the pharmacokinetics of acutely administered phenytoin in pregnant and nonpregnant rats.
Topics: Animals; Diet; Female; Folic Acid; Kinetics; Phenytoin; Pregnancy; Rats | 1984 |
Interactions between folate metabolism, phenytoin metabolism, and liver microsomal cytochrome P450.
Topics: Animals; Diet; Folic Acid; Folic Acid Deficiency; In Vitro Techniques; Liver; Male; Microsomes, Liver; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains | 1984 |
Effect of folic acid supplementation on congenital malformations due to anticonvulsive drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Drug Therapy, Combination; Epilepsy; Female; Folic Acid; Humans; Infant, Newborn; Male; Phenytoin; Pregnancy; Pregnancy Complications; Prospective Studies; Retrospective Studies | 1984 |
Effects of phenobarbitone and phenytoin on folate catabolism in the rat.
Topics: Animals; Chemical Phenomena; Chemistry; Feces; Folic Acid; Kidney; Liver; Male; Phenobarbital; Phenytoin; Rats | 1983 |
Phenytoin and folic acid interaction: a preliminary report.
Topics: Adult; Biotransformation; Drug Interactions; Folic Acid; Humans; Kinetics; Male; Middle Aged; Phenytoin | 1983 |
Phenytoin and folic acid: individualized drug-drug interaction.
Topics: Drug Interactions; Epilepsy; Folic Acid; Humans; Male; Middle Aged; Phenytoin | 1983 |
Folate supplements and phenytoin-salicylate interaction.
Topics: Adult; Aspirin; Drug Interactions; Folic Acid; Folic Acid Deficiency; Humans; Male; Phenytoin; Seizures | 1983 |
The effect of diphenylhydantoin (phenytoin) on the sequential stages of intestinal folate absorption.
Topics: Adult; Biological Transport, Active; Folic Acid; gamma-Glutamyl Hydrolase; Humans; Intestinal Absorption; Male; Phenytoin; Polyethylene Glycols | 1983 |
Detection of a milk factor that facilitates folate uptake by intestinal cells.
Topics: Animals; Calcium; Carrier Proteins; Cattle; Edetic Acid; Female; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Deficiency; Glucose; Goats; Humans; Hydrogen-Ion Concentration; Infant, Newborn; Infant, Newborn, Diseases; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Milk Proteins; Milk, Human; Phenytoin; Rats; Receptors, Cell Surface | 1981 |
Pharmacokinetics of anticonvulsant drugs.
Topics: Anticonvulsants; Binding, Competitive; Brain; Carbamazepine; Drug Interactions; Drug Tolerance; Epilepsy; Folic Acid; Humans; Kinetics; Phenobarbital; Phenytoin; Protein Binding; Tissue Distribution; Valproic Acid | 1980 |
Folic acid and the protective action of diphenylhydantoin against maximal electroshock in rats after single doses.
Topics: Animals; Anticonvulsants; Brain; Electroshock; Folic Acid; Male; Phenytoin; Rats; Rats, Inbred Strains | 1983 |
Interaction of phenytoin and folate in the rat.
Topics: Animals; Brain; Drug Interactions; Folic Acid; Male; Phenytoin; Rats; Rats, Inbred Strains; Seizures | 1983 |
[Radioimmunologic study of the plasma concentrations of folic acid and various antiepileptic preparations during the treatment of epileptic patients].
Topics: Adolescent; Adult; Anticonvulsants; Benzamidines; Drug Therapy, Combination; Epilepsy; Female; Folic Acid; Humans; Male; Phenobarbital; Phenytoin; Radioimmunoassay | 1983 |
Dilantin and folic acid status. Clinical implications for the periodontist.
Topics: Adolescent; Adult; Anemia, Megaloblastic; Child; Female; Folic Acid; Folic Acid Deficiency; Gingival Hyperplasia; Humans; Phenytoin | 1981 |
Cerebrospinal fluid and blood thiamine concentrations in phenytoin-treated epileptics.
Topics: Epilepsy; Folic Acid; Humans; Middle Aged; Phenytoin; Thiamine | 1982 |
Effect of phenytoin on folic acid uptake in isolated intestinal epithelial cells.
Topics: Animals; Chickens; Epithelium; Folic Acid; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Phenytoin | 1982 |
Effects of anticonvulsants and methotrexate on calcium disposition.
Topics: Animals; Anticonvulsants; Calcium; Calcium Radioisotopes; Folic Acid; Intestinal Absorption; Male; Methotrexate; Mice; Phenobarbital; Phenytoin | 1980 |
Intestinal folic acid absorption and the acid microclimate. The effects of compounds relevant to folate malabsorption.
Topics: Animals; Ethanol; Folic Acid; Folic Acid Deficiency; Hydrogen-Ion Concentration; In Vitro Techniques; Intestinal Absorption; Jejunum; Leucine; Malabsorption Syndromes; Methotrexate; Phenytoin; Rats | 1981 |
Folic acid and vitamin D status of young children receiving minimal anticonvulsant drug therapy.
Topics: Alkaline Phosphatase; Calcium; Child, Preschool; Female; Folic Acid; Hematocrit; Humans; Male; Nutritional Physiological Phenomena; Nutritional Requirements; Phenobarbital; Phenytoin; Phosphorus; Seizures; Vitamin D | 1981 |
Folic acid absorption test in various clinical conditions.
Topics: Adult; Aged; Atrophy; Diabetes Mellitus; Epilepsy; Folic Acid; Gastrointestinal Diseases; Humans; Hypoglycemia; Intestinal Absorption; Jejunum; Middle Aged; Phenytoin; Stomach Ulcer | 1981 |
Red cell folate levels in pregnant epileptic women.
Topics: Adult; Carbamazepine; Epilepsy; Erythrocytes; Female; Folic Acid; Follow-Up Studies; Humans; Phenytoin; Pregnancy | 1995 |
[Dilantin toxicity as a possible cause of major depression].
Topics: Aged; Depression; Female; Folic Acid; Humans; Phenytoin | 1993 |
Low serum folic acid levels in a nursing home population: a clinical experience.
Topics: Aged; Aged, 80 and over; Erythrocyte Indices; Female; Folic Acid; Folic Acid Deficiency; Hemoglobins; Homes for the Aged; Humans; Male; Nursing Homes; Phenytoin; Wisconsin | 1993 |
Phenytoin-induced depletion of folate in rats originates in liver and involves a mechanism that does not discriminate folate form.
Topics: Administration, Oral; Animals; Anticonvulsants; Bile; Brain Chemistry; Diet; Dose-Response Relationship, Drug; Folic Acid; Glutamates; Intestinal Mucosa; Liver; Male; Phenytoin; Pteridines; Random Allocation; Rats; Rats, Sprague-Dawley; Time Factors | 1997 |
Elevated plasma concentrations of homocysteine in antiepileptic drug treatment.
Topics: Age Factors; Ambulatory Care; Anticonvulsants; Carbamazepine; Convulsants; Depression, Chemical; Epilepsy; Fasting; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Pyridoxine; Risk Factors; Sex Factors; Valproic Acid; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B 6 Deficiency | 1999 |
Homocysteine concentrations and methionine loading in patients on antiepileptic drugs.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Case-Control Studies; Cytochrome P-450 Enzyme System; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Phenobarbital; Phenytoin; Primidone; Treatment Outcome; Valproic Acid; Vitamin B 12 | 2000 |
The effects of folic acid application on IL-1beta levels of human gingival fibroblasts stimulated by phenytoin and TNFalpha in vitro: a preliminary study.
Topics: Anticonvulsants; Cell Culture Techniques; Culture Media; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Folic Acid; Gingiva; Gingival Overgrowth; Humans; Interleukin-1; Phenytoin; Time Factors; Tumor Necrosis Factor-alpha | 2001 |
The effects of folic acid in the prevention of neural tube development defects caused by phenytoin in early chick embryos.
Topics: Animals; Chick Embryo; Folic Acid; Hematinics; Microscopy, Electron; Neural Crest; Neural Tube Defects; Phenytoin | 2003 |
MEGALOBLASTIC ANAEMIA ASSOCIATED WITH ANTICONVULSANT THERAPY.
Topics: Amobarbital; Anemia, Macrocytic; Anemia, Megaloblastic; Anticonvulsants; Barbiturates; Epilepsy; Folic Acid; Humans; Metabolism; Phenobarbital; Phenytoin; Primidone; Toxicology; Vitamin B 12 | 1963 |
SUBNORMAL SERUM FOLATE AND MACROCYTOSIS ASSOCIATED WITH ANTICONVULSANT DRUG THERAPY.
Topics: Anemia; Anemia, Macrocytic; Anticonvulsants; Biological Assay; Blood Chemical Analysis; Enterococcus faecalis; Epilepsy; Folic Acid; Folic Acid Antagonists; Humans; Lactobacillus; Phenobarbital; Phenytoin; Primidone; Toxicology; Vitamin B 12 | 1964 |
[MEGALOBLASTIC ANEMIA PRODUCED BY ANTICONVULSANTS].
Topics: Anemia; Anemia, Macrocytic; Anemia, Megaloblastic; Anticonvulsants; Argentina; Barbiturates; Blood Cell Count; Epilepsy; Folic Acid; Folic Acid Deficiency; Humans; Mephobarbital; Phenytoin; Primidone; Splenomegaly; Toxicology | 1963 |
IATROGENIC MEGALOBLASTIC ANAEMIA WITH NEUROLOGICAL COMPLICATIONS.
Topics: Anemia; Anemia, Macrocytic; Anemia, Megaloblastic; Brain Diseases; Cysticercosis; Drug Therapy; Epilepsy; Folic Acid; Humans; Iatrogenic Disease; Phenobarbital; Phenytoin; Primidone; Spinal Cord; Toxicology; Vitamin B 12 | 1964 |
MEGALOBLASTIC ANEMIA AND NEUROLOGIC DISTURBANCES COMBINED WITH FOLIC ACID DEFICIENCY. OBSERVATIONS ON AN EPILEPTIC PATIENT TREATED WITH ANTICONVULSANTS.
Topics: Anemia; Anemia, Macrocytic; Anemia, Megaloblastic; Anticonvulsants; Avitaminosis; Barbiturates; Brain Diseases; Central Nervous System Diseases; Cerebellar Diseases; Drug Therapy; Epilepsy; Folic Acid; Folic Acid Deficiency; Humans; Neurologic Manifestations; Pathology; Phenobarbital; Phenytoin; Spinal Cord; Spinal Nerves; Toxicology; Trimethadione | 1964 |
MEGALOBLASTIC ANAEMIA ASSOCIATED WITH ANTICONVULSANT DRUGS: STUDIES ON A CASE WITH FOUR RELAPSES.
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Anticonvulsants; Drug Therapy; Electrophoresis; Epilepsy; FIGLU Test; Folic Acid; Folic Acid Deficiency; Humans; Phenobarbital; Phenytoin; Primidone; Recurrence; Toxicology; Urine | 1965 |
Absence of effect of folic acid flour fortification on anticonvulsant drug levels.
Topics: Anticonvulsants; Flour; Folic Acid; Food, Fortified; Humans; Phenytoin | 2005 |
Seizures following reduction in phenytoin level after orally administered folic acid.
Topics: Administration, Oral; Anemia, Macrocytic; Anticonvulsants; Dose-Response Relationship, Drug; Down-Regulation; Drug Administration Schedule; Drug Interactions; Epilepsy; Epilepsy, Tonic-Clonic; Folic Acid; Humans; Male; Middle Aged; Phenytoin; Secondary Prevention | 2005 |
Effects of common anti-epileptic drug monotherapy on serum levels of homocysteine, vitamin B12, folic acid and vitamin B6.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Case-Control Studies; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Phenytoin; Pyridoxal Phosphate; Reference Values; Valproic Acid; Vitamin B 12 | 2006 |
Drug-induced pertubation of the aminothiol redox-status in patients with epilepsy: improvement by B-vitamins.
Topics: Adult; Anticonvulsants; Carbamazepine; Case-Control Studies; Cysteine; Dipeptides; Drug Evaluation; Epilepsy; Female; Folic Acid; Humans; Hyperhomocysteinemia; Liver; Male; Methionine; Oxidation-Reduction; Phenobarbital; Phenytoin; Primidone; Pyridoxine; Riboflavin; Valproic Acid; Vitamin B Deficiency | 2008 |
Basic measures and systemic medical treatment of patients with toxic epidermal necrolysis.
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Anti-Bacterial Agents; Anti-Inflammatory Agents; Anticonvulsants; Bacterial Infections; Ciprofloxacin; Drug Combinations; Female; Folic Acid; Gout Suppressants; Humans; Hydroxocobalamin; Lidocaine; Male; Middle Aged; Phenytoin; Prednisone; Pyridoxine; Stevens-Johnson Syndrome; Superinfection; Survival Rate; Trimethoprim, Sulfamethoxazole Drug Combination | 2010 |
Bisphosphonates in phenytoin-induced bone disorder.
Topics: Animals; Antioxidants; Biomarkers; Bone Density; Bone Diseases; Bone Remodeling; Diphosphonates; Dose-Response Relationship, Drug; Electroshock; Femur; Folic Acid; Homocysteine; Hydrogen Peroxide; Male; Mice; Phenytoin | 2011 |
Effects of long-term antiepileptic drug monotherapy on vascular risk factors and atherosclerosis.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Atherosclerosis; Blood Glucose; Carbamazepine; Carotid Artery, Common; Cross-Sectional Studies; Epilepsy; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Male; Middle Aged; Phenytoin; Risk Factors; Time Factors; Uric Acid; Valproic Acid; Young Adult | 2012 |
DRESS syndrome.
Topics: Administration, Oral; Adolescent; Anticonvulsants; Diagnosis, Differential; Drug Hypersensitivity Syndrome; Drug Therapy, Combination; Epilepsy; Folic Acid; Humans; Male; Phenytoin; Vitamin B Complex | 2012 |
Urate synthesis and oxidative stress in phenytoin hepatotoxicity: the role of antioxidant vitamins.
Topics: Animals; Antioxidants; Ascorbic Acid; Biomarkers; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Animal; Folic Acid; Liver; Oxidative Stress; Phenytoin; Rats, Wistar; Superoxides; Uric Acid; Vitamin E; Xanthine Oxidase | 2014 |
Nonsurgical Management of Phenytoin-induced Gingival Hyperplasia.
Topics: Anti-Infective Agents, Local; Anticonvulsants; Child; Chlorhexidine; Dental Prophylaxis; Dietary Supplements; Folic Acid; Gingival Hyperplasia; Humans; Male; Mouthwashes; Oral Hygiene; Phenytoin; Vitamin B Complex | 2015 |
Effect observation of anti epileptic drugs on serum folic acid and vitamin B12 of epileptic patients.
Topics: Adult; Anticonvulsants; Biomarkers; Case-Control Studies; Drug Monitoring; Epilepsy; Female; Folic Acid; Humans; Male; Middle Aged; Phenytoin; Risk Factors; Time Factors; Treatment Outcome; Vitamin B 12; Vitamin B Complex | 2015 |
Hyperhomocysteinaemia in children receiving phenytoin and carbamazepine monotherapy: a cross-sectional observational study.
Topics: Anticonvulsants; Carbamazepine; Case-Control Studies; Child; Child, Preschool; Cross-Sectional Studies; Epilepsy; Female; Folic Acid; Humans; Hyperhomocysteinemia; Long-Term Care; Male; Phenytoin; Vitamin B Complex | 2017 |
Homocysteine Metabolism and Hematological Parameters in Early Stage of Phenytoin Treated Epileptic Children.
Topics: Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Male; Phenytoin; Vitamin B 12 | 2017 |
Phenytoin-related ataxia in patients with epilepsy: clinical and radiological characteristics.
Topics: Antibodies; Anticonvulsants; Ataxia; Brain; Epilepsy; Female; Folic Acid; Gliadin; GTP-Binding Proteins; Humans; Longitudinal Studies; Male; Neuroimaging; Neurologic Examination; Phenytoin; Protein Glutamine gamma Glutamyltransferase 2; Sensation Disorders; Transglutaminases | 2018 |
Anti-epileptic drug and folic acid usage during pregnancy, seizure and malformation outcomes: Changes over two decades in the Kerala Registry of Epilepsy and Pregnancy.
Topics: Adult; Anticonvulsants; Carbamazepine; Female; Folic Acid; Humans; India; Lamotrigine; Levetiracetam; Oxcarbazepine; Phenytoin; Pregnancy; Pregnancy Complications; Registries; Seizures; Topiramate; Valproic Acid | 2020 |
To determine the effect of long-term antiepileptic drug on the serum folate and vitamin B12 among epileptic patients.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Folic Acid; Humans; Male; Middle Aged; Phenytoin; Vitamin B 12 | 2021 |