phenytoin and flunitrazepam

phenytoin has been researched along with flunitrazepam in 13 studies

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19907 (53.85)18.7374
1990's2 (15.38)18.2507
2000's1 (7.69)29.6817
2010's3 (23.08)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Alelyunas, YW; Bui, K; Empfield, JR; McCarthy, D; Pelosi-Kilby, L; Shen, C; Spreen, RC1
Machen, VL; Swaiman, KF1
Kontro, P; Malminen, O1
Hamon, M; Ruiz, G; Vergé, D1
Akaike, N; Kaneda, M; Oyama, Y; Wakamori, M1
Gobbi, M; Mennini, T; Testa, R1
Bresolin, N; Deshmukh, PP; Mimaki, T; Speth, RC; Yamamura, HI1
Barbi, S; Beccia, F; Ferraro, M; Pala, F; Sabato, AF1
Deshmukh, PP; Mimaki, T; Yamamura, HI1
Mol, CA; Schinkel, AH; van Deemter, L; Wagenaar, E1
Bruno-Blanch, LE; Higgs, J; Mangialavori, IC; Marder, M; Pastore, V; Wasowski, C1

Other Studies

13 other study(ies) available for phenytoin and flunitrazepam

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate.
    Bioorganic & medicinal chemistry letters, 2010, Dec-15, Volume: 20, Issue:24

    Topics: Central Nervous System Agents; Drug Evaluation, Preclinical; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Solubility

2010
Effects of phenobarbital and phenytoin on cortical glial cells in culture.
    Brain & development, 1991, Volume: 13, Issue:4

    Topics: Animals; Animals, Newborn; Benzodiazepinones; Cells, Cultured; Cerebral Cortex; Flunitrazepam; Mice; Neuroglia; Phenobarbital; Phenytoin; Radioligand Assay

1991
Gamma-aminobutyric acid and benzodiazepine receptors in cultured cerebellar granule cells: effects of taurine and its lipophilic derivatives.
    Neuropharmacology, 1989, Volume: 28, Issue:9

    Topics: Animals; Cells, Cultured; Cerebellum; Chemical Phenomena; Chemistry, Physical; Flunitrazepam; Lipids; Muscimol; Phenytoin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Taurine

1989
Chronic phenytoin treatment decreases GABAA but not beta-adrenoceptors in the cerebellum of young rats.
    European journal of pharmacology, 1989, Sep-13, Volume: 168, Issue:2

    Topics: Adrenergic beta-Antagonists; Animals; Autoradiography; Cerebellum; Female; Flunitrazepam; Kinetics; Muscimol; Phenytoin; Pindolol; Pregnancy; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Receptors, GABA-A; Tritium

1989
Effects of chlordiazepoxide, chlorpromazine, diazepam, diphenylhydantoin, flunitrazepam and haloperidol on the voltage-dependent sodium current of isolated mammalian brain neurons.
    Brain research, 1989, Aug-14, Volume: 494, Issue:2

    Topics: Animals; Chlordiazepoxide; Chlorpromazine; Diazepam; Flunitrazepam; Haloperidol; Hippocampus; In Vitro Techniques; Membrane Potentials; Phenytoin; Psychotropic Drugs; Rats; Sodium

1989
Effects of denzimol on benzodiazepine receptors in the CNS: relationship between the enhancement of diazepam activity and benzodiazepine binding sites induced by denzimol in the rat.
    Life sciences, 1984, Oct-29, Volume: 35, Issue:18

    Topics: Animals; Anticonvulsants; Biological Assay; Cerebellum; Cerebral Cortex; Female; Flunitrazepam; Hippocampus; Imidazoles; Phenytoin; Rats; Receptors, GABA-A; Seizures

1984
Neuronal localization of benzodiazepine receptors in the murine cerebellum.
    Advances in biochemical psychopharmacology, 1981, Volume: 26

    Topics: Animals; Anti-Anxiety Agents; Cerebellum; Flunitrazepam; Kainic Acid; Mutation; Neurons; Phenytoin; Pyridines; Receptors, Drug; Receptors, GABA-A

1981
The effect of five drugs in coma doses on neurotransmitter amino acids in the brains of guinea pigs.
    Resuscitation, 1983, Volume: 10, Issue:4

    Topics: Amino Acids; Animals; Brain; Brain Chemistry; Central Nervous System Agents; Central Nervous System Depressants; Diazepam; Flunitrazepam; Guinea Pigs; Neurotransmitter Agents; Phenobarbital; Phenytoin; Pregnanediones

1983
Decreased benzodiazepine receptor density in rat cerebellum following neurotoxic doses of phenytoin.
    Journal of neurochemistry, 1980, Volume: 35, Issue:6

    Topics: Animals; Cerebellar Cortex; Cerebellum; Flunitrazepam; Histocytochemistry; Male; Phenytoin; Rats; Receptors, Drug; Receptors, GABA-A

1980
P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.
    The Journal of clinical investigation, 1996, Jun-01, Volume: 97, Issue:11

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Brain; Cell Line; Clozapine; Diffusion; Domperidone; Epithelium; Flunitrazepam; Haloperidol; Humans; Kidney; Kinetics; Loperamide; Male; Mice; Mice, Inbred Strains; Ondansetron; Phenytoin; Recombinant Proteins; Structure-Activity Relationship; Swine; Tissue Distribution; Transfection

1996
A synthetic bioisoster of trimethadione and phenytoin elicits anticonvulsant effect, protects the brain oxidative damage produced by seizures and exerts antidepressant action in mice.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2014, Volume: 24, Issue:8

    Topics: Animals; Anticonvulsants; Antidepressive Agents; Brain Injuries; Disease Models, Animal; Flunitrazepam; Glutathione; Hindlimb Suspension; Lipid Peroxidation; Male; Maze Learning; Mice; Motor Activity; Pentylenetetrazole; Phenytoin; Seizures; Sodium-Potassium-Exchanging ATPase; Time Factors; Trimethadione; Veratrine

2014