phenytoin and fluconazole

phenytoin has been researched along with fluconazole in 26 studies

Research

Studies (26)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (7.69)	18.7374
1990's	6 (23.08)	18.2507
2000's	6 (23.08)	29.6817
2010's	12 (46.15)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Duffy, EM; Jorgensen, WL	1
Topliss, JG; Yoshida, F	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Campillo, NE; Guerra, A; Páez, JA	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Denning, DW; Graybill, JR; Hanson, LH; Pappagianis, D; Rinaldi, MG; Sharkey, PK; Stevens, DA; Tucker, RM	1
Carey, D; Lee, HS; Tett, S	1
Chandrasekar, PH; Edwards, DJ; Milad, MA; Touchette, MA	1
Blum, RA; Gardner, MJ; Harrison, NJ; Henry, EB; Hilligoss, DM; Schentag, JJ; Wilton, JH	1
Holland, JT; Mitchell, AS	1
Howitt, KM; Oziemski, MA	1
Cadle, RM; Hamill, RJ; Rodriguez-Barradas, MC; Zenon, GJ	1
Bellati, U; Di Ilio, C; Giampietro, F; Iammarrone, E; Lamonaca, D; Tiboni, GM	1
Angelucci, S; Bellati, U; Di Ilio, C; Giampietro, F; Moio, P; Tiboni, GM	1
Brown, HS; Chadwick, A; Houston, JB	1
Lai, Y; Li, N; Yuan, H	1
Bergman, U; Bertilsson, L; Engström Hellgren, K; Helldén, A; Masquelier, M; Nilsson Remahl, I; Odar-Cederlöf, I; Ramsjö, M	1
Gribakina, OG; Kolyvanov, GB; Novitskaia, IaG; Seredenin, SB; Smirnov, VV; Zherdev, VP	1

Reviews

2 review(s) available for phenytoin and fluconazole

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Fluconazole-induced symptomatic phenytoin toxicity. The Annals of pharmacotherapy, 1994, Volume: 28, Issue:2 Topics: Adult; AIDS-Related Opportunistic Infections; Animals; Drug Interactions; Fluconazole; Humans; Male; Middle Aged; Phenytoin; Seizures	1994

Trials

3 trial(s) available for phenytoin and fluconazole

Article	Year
Contrasting effects of fluconazole and ketoconazole on phenytoin and testosterone disposition in man. British journal of clinical pharmacology, 1992, Volume: 34, Issue:1 Topics: Administration, Oral; Adult; Fluconazole; Humans; Ketoconazole; Male; Phenytoin; Random Allocation; Testosterone	1992
Effect of fluconazole on the disposition of phenytoin. Clinical pharmacology and therapeutics, 1991, Volume: 49, Issue:4 Topics: Administration, Oral; Adult; Chromatography, High Pressure Liquid; Drug Administration Schedule; Drug Interactions; Fluconazole; Humans; Infusions, Intravenous; Male; Phenytoin; Random Allocation	1991
Teratological interaction between the bis-triazole antifungal agent fluconazole and the anticonvulsant drug phenytoin. Teratology, 1999, Volume: 59, Issue:2 Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Antifungal Agents; Body Weight; Cleft Palate; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Synergism; Embryo Loss; Female; Fetal Death; Fetus; Fluconazole; Maternal-Fetal Exchange; Mice; Phenytoin; Pregnancy; Teratogens	1999

Other Studies

21 other study(ies) available for phenytoin and fluconazole

Article	Year
Prediction of drug solubility from Monte Carlo simulations. Bioorganic & medicinal chemistry letters, 2000, Jun-05, Volume: 10, Issue:11 Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility	2000
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Interaction of azoles with rifampin, phenytoin, and carbamazepine: in vitro and clinical observations. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1992, Volume: 14, Issue:1 Topics: Adult; Aged; Antifungal Agents; Azoles; Carbamazepine; Coccidioides; Cryptococcus neoformans; Drug Interactions; Drug Therapy, Combination; Female; Fluconazole; Humans; Itraconazole; Ketoconazole; Malassezia; Male; Middle Aged; Mycoses; Phenytoin; Rifampin	1992
Drug interactions with fluconazole. The Medical journal of Australia, 1992, Mar-02, Volume: 156, Issue:5 Topics: Cross-Sectional Studies; Cyclosporine; Drug Interactions; Fluconazole; Humans; Phenytoin; Theophylline; Warfarin	1992
Fluconazole and phenytoin: a predictable interaction. BMJ (Clinical research ed.), 1989, May-13, Volume: 298, Issue:6683 Topics: Antifungal Agents; Drug Interactions; Fluconazole; Humans; Middle Aged; Phenytoin; Triazoles	1989
Phenytoin toxicity induced by fluconazole. The Medical journal of Australia, 1989, Nov-20, Volume: 151, Issue:10 Topics: Adult; Drug Interactions; Female; Fluconazole; Humans; Nystagmus, Pathologic; Phenytoin; Reflex, Abnormal	1989
Additional investigation on the potentiation of phenytoin teratogenicity by fluconazole. Toxicology letters, 2003, Dec-10, Volume: 145, Issue:3 Topics: Animals; Chromatography, High Pressure Liquid; Cleft Palate; Dose-Response Relationship, Drug; Drug Synergism; Female; Fluconazole; Injections, Intraperitoneal; Male; Maternal-Fetal Exchange; Mice; Mice, Inbred ICR; Phenytoin; Placenta; Pregnancy; Prenatal Exposure Delayed Effects; Teratogens	2003
Use of isolated hepatocyte preparations for cytochrome P450 inhibition studies: comparison with microsomes for Ki determination. Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:11 Topics: Animals; Catalysis; Cells, Cultured; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Enzyme Inhibitors; Fluconazole; Fluoxetine; Fluvoxamine; Hepatocytes; Ketoconazole; Kinetics; Male; Miconazole; Microsomes, Liver; Midazolam; Phenytoin; Quinine; Rats; Rats, Sprague-Dawley; Tolbutamide	2007
Evaluation of in vitro models for screening alkaline phosphatase-mediated bioconversion of phosphate ester prodrugs. Drug metabolism and disposition: the biological fate of chemicals, 2009, Volume: 37, Issue:7 Topics: Alkaline Phosphatase; Animals; Caco-2 Cells; Drug Delivery Systems; Drug Stability; Fluconazole; Half-Life; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Intestines; Male; Mucous Membrane; Organophosphates; Phenytoin; Phosphates; Prodrugs; Rats; Rats, Sprague-Dawley; Solubility	2009
Fluconazole-induced intoxication with phenytoin in a patient with ultra-high activity of CYP2C9. European journal of clinical pharmacology, 2010, Volume: 66, Issue:8 Topics: Alleles; Angiotensin II Type 1 Receptor Blockers; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Ataxia; Behcet Syndrome; Case-Control Studies; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Disorders of Excessive Somnolence; Dose-Response Relationship, Drug; Fatigue; Female; Fluconazole; Humans; Losartan; Middle Aged; Pharmaceutical Preparations; Phenotype; Phenytoin; Polymorphism, Genetic; Speech Intelligibility; Warfarin	2010
[In vivo evaluation of the metabolic ratio of CYP2C9 and CYP1A2 drug markers after administration of afobazole in comparison to standard inducers and inhibitors of cytochromes]. Eksperimental'naia i klinicheskaia farmakologiia, 2013, Volume: 76, Issue:11 Topics: Animals; Anti-Anxiety Agents; Anti-Bacterial Agents; Anticonvulsants; Antifungal Agents; Benzimidazoles; Ciprofloxacin; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Induction; Enzyme Inhibitors; Fluconazole; Male; Morpholines; Phenytoin; Rats; Rifampin	2013