phenytoin has been researched along with erythromycin in 34 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (20.59) | 18.7374 |
| 1990's | 4 (11.76) | 18.2507 |
| 2000's | 11 (32.35) | 29.6817 |
| 2010's | 12 (35.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Du, LP; Li, MY; Tsai, KC; Xia, L; You, QD | 1 |
| Jolivette, LJ; Ward, KW | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Abraham, MH; Acree, WE; Ibrahim, A | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Honda, K; Izumi, T; Miyaji, Y; Nakayama, S; Okazaki, O; Okudaira, N; Shiosakai, K; Sugiyama, D; Suzuki, W; Takakusa, H; Watanabe, A | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Fleckenstein, L; Horvitz, RA; Morgan, JP | 1 |
| Baciewicz, AM | 1 |
| Coulthard, K; Milne, RW; Nation, RL; Penna, AC; Roberts, G; Sansom, LN | 1 |
| Debreczeni, LA; Herjavecz, I; Szeitz, A | 1 |
| Bukowskyj, M; Munt, PW; Nakatsu, K | 1 |
| Bachmann, K; Forney, RB; Jauregui, L; Schwartz, JI | 1 |
| D'Arcy, PF | 1 |
| Hanssen, BR; Lindstrom, TD; Wrighton, SA | 1 |
| Inoue, K; Mimura, M; Nakamura, S; Oda, H; Ohmori, S; Shimada, T; Yamazaki, H | 1 |
| Hirayama, F; Iizumi, Y; Kawasaki, T; Koshio, H; Matsumoto, Y; Sato, K; Taniuchi, Y | 1 |
| Andres, A; Carreño, A; Cubas, A; Delgado, M; Dominguez-Gil, B; Herrero, JC; Latorre, A; Manzanares, C; Morales, E; Morales, JM; Moreno, M | 1 |
| Brightman, FA; Leahy, DE; Searle, GE; Thomas, S | 1 |
| Bhadresa, S; Coon, DJ; Lawrence, MS; Magiera, D; Struharik, M; Ward, KW | 1 |
| Becquemont, L; Bergmann, JF; Chhun, S; Mouly, S; Rizzo-Padoin, N; Simoneau, G; Verstuyft, C | 1 |
3 review(s) available for phenytoin and erythromycin
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Carbamazepine drug interactions.
Topics: Carbamazepine; Cimetidine; Dextropropoxyphene; Drug Interactions; Erythromycin; Humans; Isoniazid; Lithium; Phenobarbital; Phenytoin; Primidone; Protein Binding; Troleandomycin; Valproic Acid; Warfarin | 1986 |
Theophylline reassessed.
Topics: Acidosis; Aging; Allopurinol; Animals; Anti-Bacterial Agents; Breast Feeding; Bronchodilator Agents; Caffeine; Contraceptives, Oral; Cooking; Cystic Fibrosis; Drug Interactions; Erythromycin; Female; Heart Diseases; Histamine H2 Antagonists; Humans; Hypoxia; Infections; Kinetics; Liver Diseases; Lung Diseases, Obstructive; Maternal-Fetal Exchange; Phenobarbital; Phenytoin; Pregnancy; Respiration Disorders; Sleep; Smoking; Theophylline | 1984 |
1 trial(s) available for phenytoin and erythromycin
| Article | Year |
|---|---|
Lack of effect of erythromycin on the pharmacokinetics of single oral doses of phenytoin.
Topics: Administration, Oral; Adult; Drug Interactions; Erythromycin; Humans; Male; Phenytoin | 1988 |
30 other study(ies) available for phenytoin and erythromycin
| Article | Year |
|---|---|
The pharmacophore hypotheses of I(Kr) potassium channel blockers: novel class III antiarrhythmic agents.
Topics: Anti-Arrhythmia Agents; Models, Biological; Models, Molecular; Potassium Channel Blockers; Potassium Channels; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2004 |
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution | 2005 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs.
Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization | 2008 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites.
Topics: Glutathione; Pharmacology; Sulfur Radioisotopes | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Savings from generic prescriptions. A study of 33 pharmacies in Rochester, New York.
Topics: Alkanesulfonates; Ampicillin; Chlorpheniramine; Costs and Cost Analysis; Dextropropoxyphene; Drug Prescriptions; Erythromycin; Estrogens, Conjugated (USP); Fees, Pharmaceutical; Methenamine; New York; Octanols; Papaverine; Penicillin V; Pentaerythritol Tetranitrate; Pharmacies; Phenytoin; Prescription Fees; Succinates; Sulfisoxazole; Surveys and Questionnaires; Therapeutic Equivalency | 1975 |
Effects of drugs on aminophylline elimination in rats.
Topics: Aminophylline; Animals; Behavior, Animal; Carbamazepine; Cimetidine; Drug Combinations; Drug Interactions; Erythromycin; Female; Half-Life; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Rifampin; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1988 |
Single dose phenytoin clearance during erythromycin treatment.
Topics: Adult; Drug Interactions; Erythromycin; Humans; Kinetics; Male; Phenytoin; Saliva | 1984 |
Early reports on drug interactions.
Topics: Acetaminophen; Amiodarone; Apazone; Aspirin; Carbamazepine; Chlordiazepoxide; Cimetidine; Coumarins; Drug Interactions; Erythromycin; Ethanol; Furosemide; Gentamicins; Humans; Levodopa; Lidocaine; Phenytoin; Prenylamine; Quinidine | 1983 |
Cytochrome P-450 complex formation by dirithromycin and other macrolides in rat and human livers.
Topics: Animals; Anti-Bacterial Agents; Cytochrome P-450 Enzyme System; Dexamethasone; Erythromycin; Humans; In Vitro Techniques; Macrolides; Male; Microsomes, Liver; NADP; Phenobarbital; Phenytoin; Rats; Rats, Sprague-Dawley; Troleandomycin | 1993 |
Cytochrome P450-dependent drug oxidation activities in liver microsomes of various animal species including rats, guinea pigs, dogs, monkeys, and humans.
Topics: Adrenergic beta-Antagonists; Aniline Compounds; Animals; Antineoplastic Agents; Benzphetamine; Carcinogens; Coumarins; Cytochrome P-450 Enzyme System; Dogs; Erythromycin; Ethanolamines; Ethylmorphine; Guinea Pigs; Humans; Macaca fascicularis; Mephenytoin; Microsomes, Liver; Nifedipine; Oxazines; Oxidation-Reduction; Phenacetin; Phenytoin; Rats; Species Specificity | 1997 |
Comparison of the anticoagulant and antithrombotic effects of YM-75466, a novel orally-active factor Xa inhibitor, and warfarin in mice.
Topics: Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents; Anticoagulants; Anticonvulsants; Antifibrinolytic Agents; Blood Coagulation; Carbamazepine; Cimetidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Erythromycin; Factor Xa Inhibitors; Fibrinolytic Agents; Hemorrhage; Male; Mice; Mice, Inbred ICR; Partial Thromboplastin Time; Phenytoin; Piperidines; Prothrombin Time; Rifampin; Sulfonamides; Thromboembolism; Thromboplastin; Vitamin K 1; Warfarin | 1998 |
Clinical management of tacrolimus drug interactions in renal transplant patients.
Topics: Adult; Aged; Antifungal Agents; Candidiasis; Drug Interactions; Erythromycin; Female; Humans; Immunosuppressive Agents; Ketoconazole; Kidney Transplantation; Male; Phenytoin; Postoperative Complications; Rifampin; Tacrolimus | 1999 |
Application of a generic physiologically based pharmacokinetic model to the estimation of xenobiotic levels in rat plasma.
Topics: Algorithms; Animals; Area Under Curve; Clozapine; Erythromycin; Half-Life; Injections, Intravenous; Metabolic Clearance Rate; Models, Animal; Models, Biological; Multivariate Analysis; Pentazocine; Phenytoin; Rats; Reproducibility of Results; Time Factors; Xenobiotics | 2006 |
Exploration of the African green monkey as a preclinical pharmacokinetic model: oral pharmacokinetic parameters and drug-drug interactions.
Topics: Animals; Aza Compounds; Chlorocebus aethiops; Chromatography, High Pressure Liquid; Ciprofloxacin; Drug Evaluation, Preclinical; Erythromycin; Fluoroquinolones; Lidocaine; Mass Spectrometry; Models, Animal; Moxifloxacin; Pharmacokinetics; Phenytoin; Prednisolone; Propranolol; Quinolines; Species Specificity | 2009 |
The cytochrome P-450 2C9/2C19 but not the ABCB1 genetic polymorphism may be associated with the liver cytochrome 3A4 induction by phenytoin.
Topics: Adult; Alleles; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breath Tests; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Enzyme Induction; Erythromycin; France; Gene Frequency; Humans; Liver; Male; Middle Aged; Phenytoin; Polymorphism, Genetic; Radioactive Tracers; Young Adult | 2012 |