phenytoin and disulfiram

phenytoin has been researched along with disulfiram in 36 studies

Research

Studies (36)

Timeframe	Studies, this research(%)	All Research%
pre-1990	24 (66.67)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (8.33)	29.6817
2010's	8 (22.22)	24.3611
2020's	1 (2.78)	2.80

Authors

Authors	Studies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Campillo, NE; Guerra, A; Páez, JA	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M	1
Kutt, H	2
Sobue, I	1
Lamprecht, F	1
Christensen, LK; Hansen, JM	1
Birkett, DJ; Chinwah, PM; Graham, GG; Hickie, JB; Wade, DN	1
Birkett, DJ; Pond, SM	1
Hansen, JM; Kristensen, MB; Skovsted, L; Svendsen, TL	1
Brachet, A; Cenraud, P; Henry, P; Loiseau, P	1
Anisimov, VN	1
Weismann, K	1
Saxe, TG	1
Glogner, P	1
Kutt, H; Penry, JK	1
Lucas, BG	1
Kutt, H; Verebely, K	1
Koe, BK; Weissman, A	1
Kiorboe, E	2
Olesen, OV	2
Johansen, T; Jørgensen, L	1
Brown, CG; Feroli, ER; Gurley, HT; Kaminsky, MJ	1
Alexander, B; Lyon, LW; Taylor, JW	1

Reviews

6 review(s) available for phenytoin and disulfiram

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
[Exogenous toxic neuropathy (author's transl)]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1976, Aug-10, Volume: 65, Issue:8 Topics: Acrylamides; Adolescent; Adult; Aged; Aldrin; Carbon Disulfide; Chloramphenicol; Clioquinol; DDT; Disulfiram; Endrin; Ethambutol; Female; Humans; Isoniazid; Male; Middle Aged; Nervous System Diseases; Phenytoin; Sulfonamides; Thalidomide; Thiamphenicol; Trichloroethylene; Vincristine	1976
Epilepsy and schizophrenia: a neurochemical bridge. Journal of neural transmission, 1977, Volume: 40, Issue:2 Topics: Amphetamine; Anticonvulsants; Brain; Butyrophenones; Disulfiram; Dopamine; Dopamine beta-Hydroxylase; Epilepsy; Humans; Huntington Disease; Levodopa; Neurocognitive Disorders; Phenothiazines; Phenytoin; Receptors, Dopamine; Schizophrenia	1977
Drug interactions with oral sulphonylurea hypoglycaemic drugs. Drugs, 1977, Volume: 13, Issue:1 Topics: Allopurinol; Analgesics; Anticoagulants; Chloramphenicol; Chlorpropamide; Disulfiram; Drug Interactions; Ethanol; Glyburide; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Kinetics; Monoamine Oxidase Inhibitors; Novobiocin; Phenylbutazone; Phenytoin; Probenecid; Propranolol; Rifampin; Sulfonamides; Sulfonylurea Compounds; Tolbutamide	1977
Biochemical and genetic factors regulating dilantin metabolism in man. Annals of the New York Academy of Sciences, 1971, Jul-06, Volume: 179 Topics: Aminosalicylic Acids; Animals; Ataxia; Cats; Chlordan; Cycloserine; DDT; Dicumarol; Disulfiram; Enzyme Induction; Female; Genetics, Medical; Humans; Intestinal Absorption; Isoniazid; Kinetics; Liver Diseases; Male; Metabolism; Microsomes, Liver; Nystagmus, Pathologic; Pedigree; Pharmacogenetics; Phenobarbital; Phenytoin; Rats; Thiazines	1971
Usefulness of blood levels of antiepileptic drugs. Archives of neurology, 1974, Volume: 31, Issue:5 Topics: Anticonvulsants; Carbamazepine; Chloramphenicol; Chlordiazepoxide; Chlorpromazine; Chromatography, Gas; Dextropropoxyphene; Diazepam; Dicumarol; Disulfiram; Drug Interactions; Epilepsy; Ethosuximide; Humans; Isoniazid; Methylphenidate; Phenethylamines; Phenobarbital; Phenylbutazone; Phenytoin; Primidone; Prochlorperazine; Sulfamethizole; Sulfaphenazole; Thiazines	1974

Trials

1 trial(s) available for phenytoin and disulfiram

Article	Year
Phenytoin intoxication during treatment with antabuse (Disulfiram). Epilepsia, 1966, Volume: 7, Issue:3 Topics: Adult; Alcoholism; Clinical Trials as Topic; Disulfiram; Drug Compounding; Drug Incompatibility; Epilepsy; Humans; Male; Phenytoin	1966

Other Studies

29 other study(ies) available for phenytoin and disulfiram

Article	Year
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology. Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3 Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries	2023
Interactions of antiepileptic drugs. Epilepsia, 1975, Volume: 16, Issue:2 Topics: Anti-Infective Agents; Anticonvulsants; Benzodiazepines; Biotransformation; Blood Proteins; Carbamazepine; Dextropropoxyphene; Dicumarol; Disulfiram; Drug Interactions; Ethosuximide; Humans; Intestinal Absorption; Isoniazid; Methylphenidate; Phenethylamines; Phenobarbital; Phenothiazines; Phenytoin; Primidone; Protein Binding; Thiazines	1975
Multiple drug interactions with phenytoin. The Medical journal of Australia, 1977, Oct-01, Volume: 2, Issue:14 Topics: Alcoholism; Disulfiram; Epilepsy; Female; Humans; Middle Aged; Phenytoin; Substance Withdrawal Syndrome	1977
Metabolic drug interactions--a critical review. The Medical journal of Australia, 1975, May-31, Volume: 1, Issue:22 Topics: Alcohol Oxidoreductases; Aldehyde Oxidoreductases; Anticoagulants; Barbiturates; Chloral Hydrate; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Depression, Chemical; Disulfiram; Drug Interactions; Enzyme Induction; Ethanol; Glucuronosyltransferase; Humans; Liver; Microsomes, Liver; Phenytoin; Polycyclic Compounds; Tolbutamide	1975
The influence of disulfiram on the half life and metabolic clearance rate of diphenylhydantoin and tolbtamide in man. European journal of clinical pharmacology, 1976, Mar-22, Volume: 09, Issue:5-6 Topics: Adult; Aged; Disulfiram; Drug Interactions; Female; Half-Life; Humans; Kinetics; Male; Metabolic Clearance Rate; Middle Aged; Phenytoin; Tolbutamide	1976
[Letter: Diphenylhydrantoin poisoning during disulfiram therapy]. La Nouvelle presse medicale, 1975, Feb-15, Volume: 4, Issue:7 Topics: Adult; Alcoholism; Biotransformation; Disulfiram; Enzyme Inhibitors; Epilepsy; Humans; Liver; Male; Phenytoin	1975
[Pharmacologic study of adrenergic mechanisms of compensatory hypertrophy of the ovary]. Biulleten' eksperimental'noi biologii i meditsiny, 1975, Volume: 80, Issue:12 Topics: Animals; Castration; Chlorpromazine; Diethylstilbestrol; Disulfiram; Female; Follicle Stimulating Hormone; Levodopa; Methyldopa; Ovary; Phenytoin; Rats; Sympathetic Nervous System	1975
Chelating drugs and zinc. Danish medical bulletin, 1986, Volume: 33, Issue:4 Topics: Animals; Chelating Agents; Disulfiram; Ethambutol; Humans; Organometallic Compounds; Oxyquinoline; Penicillamine; Phenytoin; Pyridines; Rats; Tetracycline; Zinc	1986
Drug-alcohol interactions. American family physician, 1986, Volume: 33, Issue:4 Topics: Anticoagulants; Central Nervous System Depressants; Disulfiram; Drug Interactions; Ethanol; Gluconeogenesis; Humans; Nicotiana; Phenytoin; Plants, Toxic; Smoking; Vasodilator Agents	1986
[Unfavorable and problematic drug combinations. IV]. Der Internist, 1970, Volume: 11, Issue:11 Topics: Amphetamine; Ataxia; Bone Marrow; Cerebral Hemorrhage; Depression, Chemical; Dicumarol; Dihydroxyphenylalanine; Disulfiram; Drug Antagonism; Ephedrine; Humans; Hypertension; Hypotension; Isoniazid; Mercaptopurine; Methamphetamine; Microsomes, Liver; Monoamine Oxidase Inhibitors; Norepinephrine; Phenethylamines; Phenytoin; Reserpine; Stimulation, Chemical; Thiazines; Thiopental; Tyramine	1970
"Dilantin" overdosage. The Medical journal of Australia, 1968, Oct-12, Volume: 2, Issue:15 Topics: Aminosalicylic Acids; Anticonvulsants; Calcium; Dicumarol; Disulfiram; Drug Synergism; Drug Tolerance; Humans; Isoniazid; Lactose; Phenylbutazone; Phenytoin; Sulfaphenazole; Sulfates; Thiazines	1968
Metabolism of diphenylhydantoin by rat liver microsomes. I. characteristics of the reaction. Biochemical pharmacology, 1970, Volume: 19, Issue:3 Topics: Adenosine Triphosphate; Animals; Azides; Biotransformation; Chlordiazepoxide; Chlorpromazine; Dextropropoxyphene; Diazepam; Diethylstilbestrol; Dimenhydrinate; Disulfiram; Hydantoins; Hydrogen-Ion Concentration; In Vitro Techniques; Isoniazid; Kinetics; Male; Methylene Blue; Microsomes, Liver; NAD; NADP; Oxygen; Phenobarbital; Phenytoin; Proadifen; Prochlorperazine; Rats; Sodium; Temperature	1970
m-Fluorotyrosine convulsions and mortality: relationship to catecholamine and citrate metabolism. The Journal of pharmacology and experimental therapeutics, 1967, Volume: 155, Issue:1 Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Anticonvulsants; Atropine; Azoles; Brain; Chlordiazepoxide; Chlorpromazine; Citrates; Dihydroxyphenylalanine; Disulfiram; Drug Antagonism; Drug Synergism; Kidney; Lysergic Acid Diethylamide; Male; Methyldopa; Mice; Morphine; Nialamide; Norepinephrine; Pargyline; Phenobarbital; Phenytoin; Reserpine; Seizures; Serotonin; Strychnine; Tetrabenazine; Trimethadione; Tyrosine; Urea	1967
[Antabuse as a cause of poisoning with phenytoin]. Ugeskrift for laeger, 1966, Dec-22, Volume: 128, Issue:51 Topics: Adult; Disulfiram; Humans; Male; Phenytoin	1966
Disulfiramum (antabuse) as inhibitor of phenytoin metabolism. Acta pharmacologica et toxicologica, 1966, Volume: 24, Issue:4 Topics: Adult; Disulfiram; Drug Antagonism; Humans; Male; Phenobarbital; Phenytoin; Primidone; Spectrophotometry	1966
The influence of disulfiram and calcium carbimide on the serum diphenylhydantoin. Excretion of HPPH in the urine. Archives of neurology, 1967, Volume: 16, Issue:6 Topics: Acetazolamide; Adult; Aged; Alcoholism; Amitriptyline; Chlordiazepoxide; Chlorpromazine; Chromatography, Thin Layer; Cyanates; Disulfiram; Drug Synergism; Epilepsy; Humans; Hydroflumethiazide; Imipramine; Male; Middle Aged; Phenobarbital; Phenytoin; Primidone	1967
Affinity of drugs for cytochrome P-450 determined by inhibition of p-nitrophenetole O-deethylation by rat liver microsomes. Acta pharmacologica et toxicologica, 1983, Volume: 53, Issue:1 Topics: Animals; Biotransformation; Carbon Monoxide; Chloramphenicol; Cytochrome P-450 Enzyme System; Disulfiram; Drug Interactions; Isoniazid; Kinetics; Male; Microsomes, Liver; Nitrobenzenes; Nitrophenols; Oxidation-Reduction; Phenytoin; Proadifen; Rats; Rats, Inbred Strains	1983
Delirium with phenytoin and disulfiram administration. Annals of emergency medicine, 1983, Volume: 12, Issue:5 Topics: Delirium; Disulfiram; Drug Interactions; Humans; Male; Middle Aged; Phenytoin	1983
Mathematical analysis of a phenytoin--disulfiram interaction. American journal of hospital pharmacy, 1981, Volume: 38, Issue:1 Topics: Disulfiram; Drug Interactions; Humans; Kinetics; Male; Middle Aged; Models, Biological; Phenytoin	1981