phenytoin has been researched along with dextromethorphan in 20 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (25.00) | 18.7374 |
| 1990's | 7 (35.00) | 18.2507 |
| 2000's | 4 (20.00) | 29.6817 |
| 2010's | 4 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Bloomer, WD; Papadopoulou, MV; Rosenzweig, HS | 1 |
| Enna, SJ; Karbon, EW | 1 |
| Karbon, EW; Naper, K; Pontecorvo, MJ | 1 |
| Klein, M; Musacchio, JM; Paturzo, JJ | 1 |
| Klein, M; Musacchio, JM; Santiago, LJ | 2 |
| Ferkany, JW; Pontecorvo, MJ; Tortella, FC | 1 |
| Musacchio, JM; Tortella, FC | 1 |
| Thompson, KW; Wasterlain, CG | 1 |
| Allen, JT; DeHaven-Hudkins, DL; Ford-Rice, FY; Hudkins, RL | 1 |
| Kamei, H; Kameyama, T; Nabeshima, T | 2 |
| Chaki, S; Muramatsu, M; Nakazato, A; Ogawa, S; Okuyama, S; Tanaka, M; Tomisawa, K | 1 |
| Baeyens, JM; Cobos, EJ; Del Pozo, E | 1 |
| Gotti, R; Ronsisvalle, G; Santagati, NA | 1 |
| Brown, HS; Chadwick, A; Houston, JB | 1 |
3 review(s) available for phenytoin and dextromethorphan
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Pharmacological characterization of sigma binding sites in guinea pig brain membranes.
Topics: Animals; Brain; Dextromethorphan; Drug Synergism; Guinea Pigs; Haloperidol; Membranes; Phenytoin; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Receptors, sigma | 1991 |
Allosteric modulation of dextromethorphan binding sites.
Topics: Animals; Anticonvulsants; Binding Sites; Cyclopentanes; Dextromethorphan; Levorphanol; Noscapine; Phenytoin; Receptors, Neurotransmitter | 1987 |
17 other study(ies) available for phenytoin and dextromethorphan
| Article | Year |
|---|---|
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
The antitubercular activity of various nitro(triazole/imidazole)-based compounds.
Topics: Animals; Antitubercular Agents; Cell Line; Chlorocebus aethiops; Dose-Response Relationship, Drug; Humans; Imidazoles; Macrophages; Mice; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Nitro Compounds; Structure-Activity Relationship; Triazoles | 2017 |
[3H]DTG and [3H](+)-3-PPP label pharmacologically distinct sigma binding sites in guinea pig brain membranes.
Topics: Animals; Binding, Competitive; Brain; Dextromethorphan; Dopamine Agents; Guanidines; Guinea Pigs; Haloperidol; In Vitro Techniques; Kinetics; Membranes; Phenazocine; Phenytoin; Piperidines; Receptors, Opioid; Receptors, sigma | 1991 |
Effects of dextromethorphan site ligands and allosteric modifiers on the binding of (+)-[3H]3-(-3-hydroxyphenyl)-N-(1-propyl)piperidine.
Topics: Allosteric Regulation; Animals; Binding Sites; Binding, Competitive; Dextromethorphan; Guinea Pigs; In Vitro Techniques; Levorphanol; Phenytoin; Piperazines; Piperidines; Receptors, Opioid; Receptors, sigma | 1989 |
High affinity dextromethorphan binding sites in guinea pig brain: further characterization and allosteric interactions.
Topics: Animals; Binding Sites; Brain; Dextromethorphan; Ethanol; Guinea Pigs; Hydrogen-Ion Concentration; Kinetics; Levorphanol; Male; Phenytoin; Piperazines; Protein Conformation; Stereoisomerism; Temperature | 1988 |
Anticonvulsant effects of dextrorphan in rats: possible involvement in dextromethorphan-induced seizure protection.
Topics: Animals; Anticonvulsants; Dextromethorphan; Dextrorphan; Electroshock; Levorphanol; Male; Morphinans; Naloxone; Phenytoin; Rats; Rats, Inbred Strains | 1988 |
Dextromethorphan and carbetapentane: centrally acting non-opioid antitussive agents with novel anticonvulsant properties.
Topics: Animals; Anticonvulsants; Antitussive Agents; Cyclopentanes; Dextromethorphan; Drug Synergism; Electroshock; Levorphanol; Male; Phenytoin; Rats; Rats, Inbred Strains; Seizures | 1986 |
Dextromethorphan and its combination with phenytoin facilitate kindling.
Topics: Animals; Dextromethorphan; Drug Interactions; Electric Stimulation; Hippocampus; Kindling, Neurologic; Male; Phenytoin; Rats; Rats, Sprague-Dawley; Seizures | 1993 |
Allosteric modulation of ligand binding to [3H](+)pentazocine-defined sigma recognition sites by phenytoin.
Topics: Allosteric Regulation; Animals; Binding Sites; Cyclopentanes; Dextromethorphan; Dextrorphan; Guinea Pigs; Ligands; Male; Pentazocine; Phenazocine; Phenytoin; Piperidines; Radioligand Assay; Receptors, sigma; Tritium | 1993 |
(+)-SKF-10,047 and dextromethorphan ameliorate conditioned fear stress via dopaminergic systems linked to phenytoin-regulated sigma 1 sites.
Topics: Animals; Benzazepines; Conditioning, Classical; Dextromethorphan; Dopamine Antagonists; Drug Interactions; Fear; Male; Mice; Neurons; Oxidopamine; Phenazocine; Phenytoin; Receptors, Dopamine; Receptors, sigma; Sulpiride | 1996 |
Solubilization and characterization of binding sites for [3H]NE-100, a novel and potent sigma 1 ligand, from guinea pig brain.
Topics: Animals; Anisoles; Binding, Competitive; Brain; Dextromethorphan; Guinea Pigs; Ligands; Male; Pentazocine; Phenytoin; Propylamines; Radioligand Assay; Receptors, sigma; Tritium | 1996 |
(+)-SKF-10,047 and dextromethorphan ameliorate conditioned fear stress through the activation of phenytoin-regulated sigma 1 sites.
Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Behavior, Animal; Dextromethorphan; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Male; Mice; Motor Activity; Phenazocine; Phencyclidine; Phenytoin; Pyrimidines; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Stress, Physiological | 1996 |
Phenytoin differentially modulates the affinity of agonist and antagonist ligands for sigma 1 receptors of guinea pig brain.
Topics: Allosteric Regulation; Animals; Anisoles; Anticonvulsants; Binding, Competitive; Brain; Dextromethorphan; Drug Interactions; Ethylenediamines; Guinea Pigs; Haloperidol; Ligands; Male; Morpholines; Neurons; Phenazocine; Phenytoin; Piperazines; Piperidines; Progesterone; Propylamines; Receptors, sigma; Synaptic Transmission | 2005 |
Simultaneous determination of phenytoin and dextromethorphan in urine by solid-phase extraction and HPLC-DAD.
Topics: Anticonvulsants; Antitussive Agents; Chromatography, High Pressure Liquid; Dextromethorphan; Humans; Phenytoin; Primidone; Sensitivity and Specificity; Time Factors | 2005 |
Use of isolated hepatocyte preparations for cytochrome P450 inhibition studies: comparison with microsomes for Ki determination.
Topics: Animals; Catalysis; Cells, Cultured; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Enzyme Inhibitors; Fluconazole; Fluoxetine; Fluvoxamine; Hepatocytes; Ketoconazole; Kinetics; Male; Miconazole; Microsomes, Liver; Midazolam; Phenytoin; Quinine; Rats; Rats, Sprague-Dawley; Tolbutamide | 2007 |