phenytoin and cyclosporine

phenytoin has been researched along with cyclosporine in 81 studies

Research

Studies (81)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	30 (37.04)	18.2507
2000's	25 (30.86)	29.6817
2010's	24 (29.63)	24.3611
2020's	2 (2.47)	2.80

Authors

Authors	Studies
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M	1
Baltes, S; Fedrowitz, M; Gastens, AM; Kaever, V; Löscher, W; Potschka, H	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Helaiel, EH; Lashin, AN; Sobhi, MA	1
Bernimoulin, JP; Hinz, N; Romanos, GE; Schröter-Kermani, C	1
Bigler, S; Hänseler, E; Wad, N	1
Carey, D; Lee, HS; Tett, S	1
Chowdhury, MH; Dempster, DW; Hamada, C	1
Hannak, V; Herrmann, D	1
Ellis, JS; Seymour, RA; Thomason, JM	2
Levine, RA; Rees, TD	1
Seymour, RA	1
Dongari, A; Langlais, RP; McDonnell, HT	1
Hortin, GL; Landt, M; Smith, CH	1
Tanira, MO; Wasfi, IA	1
Bernimoulin, JP; Romanos, GE; Strub, JR	1
Eisen, D	1
Akalin, FA; Bozkurt, FY; Eratalay, K; Kalfa, Z; Renda, N; Sengün, D; Velidedeoglu, E	1
Bakatselou, V; Dressman, JB; Mithani, SD; TenHoor, CN	1
Ishida, H; Morisaki, I; Nagata, T; Nishikawa, S; Oka, T	1
Berini, L; Brunet, L; Farré, M; Mendieta, C; Miranda, J	1
Cutler, CW; Dill, RE; Doxey, D; Fojt, J; Gonzales, A; Iacopino, AM; Nares, S; Stoever, K	1
Chaushu, G; Givol, N; Katz, J; Shemer, J; Taicher, S	1
Blankenau, R; Keene, JJ; Mattson, JS	1
Botha, PJ	1
Desai, P; Silver, JG	1
Hall, EE	1
Chosidow, O; Cribier, B	1
Broccoletti, R; Carbone, M; Carrozzo, M; Gandolfo, S; Garzino-Demo, P	1
Meraw, SJ; Sheridan, PJ	1
Dongari-Bagtzoglou, AI; Morton, RS	1
Bartold, PM; Marshall, RI	1
Albright, GM; Chou, HH; Iacopino, AM; Murayama, Y; Nares, S; Naruishi, K; Nishimura, F; Takashiba, S; Yamada, H	1
Arriba, L; de Andrés, A; Hernández, G; Lucas, M	1
Firatli, E; Hong, HH; Kantarci, A; Sheff, MC; Trackman, PC; Uygur, C; Uzel, MI	1
Beattie, TJ; Hodges, CB; Jindal, RM; Maxwell, H; Murphy, AV	1
Taylor, BA	1
Nghiem, DD	1
Echizen, H; Kanamori, M; Takahashi, H	1
Harman, KE; Higgins, EM; Morris, SD	1
Agarwal, SK; Garg, D; Kubba, S; Makhija, A; Pathania, A; Prakash, A; Prakash, N; Singh, NP	1
Jaiarj, N	1
Kantarci, A; Trackman, PC	1
Evans, CG; Formea, CM; Karlix, JL	1
Avilés Izquierdo, J; Chavarria Mur, E; García Sánchez, I; Gilsanz Fernández, C; Molina Sánchez-Cabezudo, F; Vera López, E	1
Buduneli, E; Buduneli, N; Cinar, S; Kinane, DF; Lappin, D	1
Augustin, P; Firatli, E; Graves, DT; Hasturk, H; Kantarci, A; Sheff, MC; Trackman, PC	1
Castro, AL; Crivelini, MM; Garcia, JF; Kanno, CM; Oliveira, JA	1
Liu, HY; Liu, X; Liu, XD; Liu, YC; Wang, GJ; Xie, L; Yang, HW; Zhang, DM	1
Bhattacharyya, I; Cohen, D	1
Blanchet, B; Jullien, V; Tod, M; Vinsonneau, C	1
Hara, Y; Kaneko, T; Ozaki, Y; Suzuki, AM; Yoshimura, A	1
Danjo, K; Niwa, T; Shimabara, H	1
Kantarci, A; Kim, YS; Nseir, Z; Sume, SS; Trackman, PC	1
Ashrafi, SS; Nakib, N	1
Aarabi, M; Allabi, AC; Almond, LM; Ghobadi, C; Jamei, M; Johnson, TN; Rostami-Hodjegan, A; Rowland-Yeo, K	1
Bagheri, H; Bondon-Guitton, E; Montastruc, JL	1
Bush, ED; Fabian, E; Herold, M; Kamp, HG; Krennrich, G; Looser, R; Mattes, WB; Mellert, W; Moeller, N; Nadanaciva, S; Naraoka, H; Omura, K; Piccoli, SP; Prokoudine, A; Ruiz-Noppinger, P; Schuppe-Koistinen, I; Strauss, V; van Ravenzwaay, B; Walk, T	1
Namdari, M; Rezazadeh, F; Salman, BN; Vahabi, S	1
Abdul-Rahman, M; Al-Hamilly, NS; Grawish, ME; Mourad, MI; Radwan, LR	1
Bartold, PM; Hughes, FJ	1
Bian, Z; Fang, YJ; Meng, LY; Tay, FR; Zhao, XH	1
Ervolino, E; Kanno, CM; Oliveira, JA; Soubhia, AMP	1
Song, J; Wang, X; Wu, J; Zhang, R; Zhu, J	1

Reviews

25 review(s) available for phenytoin and cyclosporine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Drug-induced gingival overgrowth and its management. Journal of the Royal College of Surgeons of Edinburgh, 1993, Volume: 38, Issue:6 Topics: Calcium Channel Blockers; Cyclosporine; Gingival Hypertrophy; Humans; Phenytoin	1993
Systematic drugs as a risk factor for periodontal disease initiation and progression. Compendium (Newtown, Pa.), 1995, Volume: 16, Issue:1 Topics: Calcium Channel Blockers; Cyclosporine; Female; Fibromatosis, Gingival; Gingival Hyperplasia; Gonadal Steroid Hormones; Humans; Male; Nifedipine; Phenytoin	1995
Drug-induced gingival overgrowth. Adverse drug reactions and toxicological reviews, 1993,Winter, Volume: 12, Issue:4 Topics: Animals; Calcium Channel Blockers; Cyclosporine; Folic Acid; Gingiva; Humans; Phenytoin	1993
Drug-induced gingival overgrowth. Oral surgery, oral medicine, and oral pathology, 1993, Volume: 76, Issue:4 Topics: Anticonvulsants; Calcium Channel Blockers; Cyclosporine; Gingival Hypertrophy; Humans; Phenytoin	1993
The therapy of oral lichen planus. Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists, 1993, Volume: 4, Issue:2 Topics: Administration, Topical; Adrenal Cortex Hormones; Anti-Bacterial Agents; Antifungal Agents; Antiviral Agents; Candidiasis, Oral; Cryosurgery; Cyclosporine; Humans; Lichen Planus; Mouth Diseases; Mouth Mucosa; Phenytoin; PUVA Therapy; Retinoids	1993
The pathogenesis of drug-induced gingival overgrowth. Journal of clinical periodontology, 1996, Volume: 23, Issue:3 Pt 1 Topics: Adult; Age Factors; Anticonvulsants; Calcium Channel Blockers; Child; Cyclosporine; Dental Plaque; Fibroblasts; Gingiva; Gingival Hyperplasia; Gingivitis; Growth Substances; Humans; Immunosuppressive Agents; Phenytoin	1996
Pathogenesis of drug-induced gingival overgrowth. A review of studies in the rat model. Journal of periodontology, 1996, Volume: 67, Issue:5 Topics: Age Factors; Animals; Anticonvulsants; Calcium Channel Blockers; Cyclosporine; Dental Plaque; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Gingival Hyperplasia; Gingivitis; Humans; Immunosuppressive Agents; Male; Nifedipine; Phenytoin; Rats; Rats, Inbred F344; Sex Factors; Specific Pathogen-Free Organisms	1996
Gingival enlargement induced by drugs. Drug safety, 1996, Volume: 15, Issue:3 Topics: Anticonvulsants; Calcium Channel Blockers; Cyclosporine; Gingival Hyperplasia; Humans; Immunosuppressive Agents; Nifedipine; Phenytoin	1996
Drug-induced gingival hyperplasia and its management--a literature review. The Journal of the Dental Association of South Africa = Die Tydskrif van die Tandheelkundige Vereniging van Suid-Afrika, 1997, Volume: 52, Issue:11 Topics: Anticonvulsants; Calcium Channel Blockers; Clinical Protocols; Cyclosporine; Gingival Hyperplasia; Humans; Immunosuppressive Agents; Nifedipine; Phenytoin	1997
Drug-induced gingival enlargements. Journal (Canadian Dental Association), 1998, Volume: 64, Issue:4 Topics: Anticonvulsants; Calcium Channel Blockers; Cyclosporine; Gingival Overgrowth; Humans; Immunosuppressive Agents; Nifedipine; Phenytoin; Verapamil	1998
Prevention and treatment considerations in patients with drug-induced gingival enlargement. Current opinion in periodontology, 1997, Volume: 4 Topics: Anticonvulsants; Calcium Channel Blockers; Cyclosporine; Dental Prophylaxis; Gingival Overgrowth; Gingivectomy; Humans; Immunosuppressive Agents; Nifedipine; Oral Hygiene; Phenytoin	1997
[Lichen]. Annales de dermatologie et de venereologie, 1997, Volume: 124, Issue:1 Topics: Adrenal Cortex Hormones; Cyclosporine; Dapsone; Griseofulvin; Humans; Immunosuppressive Agents; Lichen Planus; Metronidazole; Phenytoin; PUVA Therapy; Retinoids	1997
[An increase in gingival volume induced by drugs (phenytoin, cyclosporine and calcium antagonists). A review of the literature]. Minerva stomatologica, 1998, Volume: 47, Issue:9 Topics: Anticonvulsants; Calcium Channel Blockers; Cyclosporine; Gingival Overgrowth; Humans; Immunosuppressive Agents; Phenytoin	1998
Medically induced gingival hyperplasia. Mayo Clinic proceedings, 1998, Volume: 73, Issue:12 Topics: Anticonvulsants; Calcium Channel Blockers; Cyclosporine; Gingival Hyperplasia; Humans; Immunosuppressive Agents; Phenytoin	1998
A clinical review of drug-induced gingival overgrowths. Australian dental journal, 1999, Volume: 44, Issue:4 Topics: Anticonvulsants; Australia; Calcium Channel Blockers; Cyclosporine; Drug Interactions; Gingival Overgrowth; Humans; Immunosuppressive Agents; Oral Hygiene; Phenytoin	1999
Reduction of severe gingival overgrowth in a kidney transplant patient by replacing cyclosporin A with tacrolimus. Journal of periodontology, 2000, Volume: 71, Issue:10 Topics: Anticonvulsants; Cyclosporine; Drug Synergism; Drug Therapy, Combination; Epilepsy; Female; Gingival Overgrowth; Humans; Immunosuppressive Agents; Kidney Transplantation; Middle Aged; Phenytoin; Tacrolimus; Time Factors	2000
Drug-induced gingival overgrowth. Journal of the Massachusetts Dental Society, 2003,Fall, Volume: 52, Issue:3 Topics: Anticonvulsants; Calcium Channel Blockers; Cyclosporine; Gingival Hyperplasia; Humans; Immunosuppressive Agents; Phenytoin	2003
Connective tissue metabolism and gingival overgrowth. Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists, 2004, Jun-04, Volume: 15, Issue:3 Topics: Animals; Anticonvulsants; Antihypertensive Agents; Connective Tissue; Connective Tissue Growth Factor; Cyclosporine; Extracellular Matrix; Fibroblasts; Gingival Overgrowth; Growth Substances; Humans; Immediate-Early Proteins; Immunosuppressive Agents; Intercellular Signaling Peptides and Proteins; Nifedipine; Phagocytosis; Phenytoin	2004
Altered cytochrome p450 metabolism of calcineurin inhibitors: case report and review of the literature. Pharmacotherapy, 2005, Volume: 25, Issue:7 Topics: Adult; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Calcineurin; Calcineurin Inhibitors; Cyclosporine; Cytochrome P-450 CYP3A; Female; Graft Rejection; Humans; Immunosuppressive Agents; Kidney Transplantation; Oxidoreductases, N-Demethylating; Phenytoin; Tacrolimus	2005
Influence of burns on pharmacokinetics and pharmacodynamics of drugs used in the care of burn patients. Clinical pharmacokinetics, 2008, Volume: 47, Issue:10 Topics: Analgesics; Anesthetics; Animals; Anti-Infective Agents; Anti-Ulcer Agents; Anticonvulsants; Burns; Cyclosporine; Drug Administration Schedule; Humans; Immunosuppressive Agents; Neuromuscular Nondepolarizing Agents; Phenytoin	2008
Drug-induced gingival overgrowth. Disease-a-month : DM, 2011, Volume: 57, Issue:4 Topics: Adult; Anticonvulsants; Calcium Channel Blockers; Child; Cyclosporine; Gingiva; Gingival Overgrowth; Humans; Immunosuppressive Agents; Nifedipine; Phenytoin; Prevalence; Risk Factors	2011
Periodontal complications of prescription and recreational drugs. Periodontology 2000, 2018, Volume: 78, Issue:1 Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Calcium Channel Blockers; Cannabis; Contraceptives, Oral; Cyclosporine; Diphosphonates; Gingiva; Gingival Overgrowth; Hallucinogens; Hormone Replacement Therapy; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Illicit Drugs; Immunosuppressive Agents; Inflammation; Methadone; Periodontal Diseases; Periodontal Index; Periodontium; Phenytoin; Platelet Aggregation Inhibitors; Tropanes	2018
Drug-induced excess hair growth. Prescrire international, 2017, Volume: 26, Issue:182 Topics: Adrenal Cortex Hormones; Androgens; Anticonvulsants; Cyclosporine; Dinoprost; ErbB Receptors; Hirsutism; Humans; Hypertrichosis; Immunosuppressive Agents; Minoxidil; Oxytocics; Phenytoin; Protein Kinase Inhibitors; Vasodilator Agents	2017
Bibliometric analysis of research trends and characteristics of drug-induced gingival overgrowth. Frontiers in public health, 2022, Volume: 10 Topics: Amlodipine; Anticonvulsants; Bibliometrics; Calcium Channel Blockers; Cyclosporine; Gingival Overgrowth; Humans; Immunosuppressive Agents; Nifedipine; Phenytoin	2022

Trials

1 trial(s) available for phenytoin and cyclosporine

Article	Year
Analyses of the pattern of therapeutic drug monitoring in a university hospital laboratory. Suitability and performance of the CEDIA assays. Wiener klinische Wochenschrift. Supplementum, 1992, Volume: 191 Topics: Carbamazepine; Chromatography, High Pressure Liquid; Cyclosporine; Digoxin; Dose-Response Relationship, Drug; Drug Monitoring; Drug Therapy; Humans; Immunoenzyme Techniques; Pharmacokinetics; Phenobarbital; Phenytoin; Quality Control; Theophylline	1992

Article

Year

Analyses of the pattern of therapeutic drug monitoring in a university hospital laboratory. Suitability and performance of the CEDIA assays.

Wiener klinische Wochenschrift. Supplementum, 1992, Volume: 191

Topics: Carbamazepine; Chromatography, High Pressure Liquid; Cyclosporine; Digoxin; Dose-Response Relationship, Drug; Drug Monitoring; Drug Therapy; Humans; Immunoenzyme Techniques; Pharmacokinetics; Phenobarbital; Phenytoin; Quality Control; Theophylline

1992

Other Studies

55 other study(ies) available for phenytoin and cyclosporine

Article	Year
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology. Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3 Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries	2023
Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein. Neuropharmacology, 2007, Volume: 52, Issue:2 Topics: Analysis of Variance; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Transport; Carbamazepine; Cell Line; Cyclosporine; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Gene Expression; Humans; Levetiracetam; Mice; Phenytoin; Piracetam; Transfection	2007
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment. Journal of applied toxicology : JAT, 2012, Volume: 32, Issue:10 Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Comparative study of ultrastructural changes of the gingival hyperplasia induced by cyclosporine and dilantin. Egyptian dental journal, 1992, Volume: 38, Issue:1 Topics: Adult; Cyclosporine; Gingiva; Gingival Hyperplasia; Humans; Microscopy, Electron; Middle Aged; Phenytoin	1992
Distribution of fibronectin in healthy, inflamed and drug-induced gingival hyperplasia. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 1992, Volume: 21, Issue:6 Topics: Actin Cytoskeleton; Adult; Connective Tissue; Connective Tissue Cells; Cyclosporine; Dental Plaque; Epithelium; Female; Fibronectins; Fluorescent Antibody Technique; Gingiva; Gingival Hemorrhage; Gingival Hyperplasia; Gingival Pocket; Gingivitis; Humans; Male; Middle Aged; Nifedipine; Phenytoin	1992
Drug interactions with fluconazole. The Medical journal of Australia, 1992, Mar-02, Volume: 156, Issue:5 Topics: Cross-Sectional Studies; Cyclosporine; Drug Interactions; Fluconazole; Humans; Phenytoin; Theophylline; Warfarin	1992
Effects of heparin on osteoclast activity. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1992, Volume: 7, Issue:7 Topics: Animals; Bone Resorption; Cells, Cultured; Chickens; Chondroitin Sulfates; Culture Media; Cyclosporine; Dextran Sulfate; Heparin; Histamine; Leupeptins; Osteoclasts; Phenytoin; Protamines; Rats	1992
[Periodontal side effects of the immunosuppressant cyclosporin A. Clinical study]. Deutsche zahnarztliche Zeitschrift, 1991, Volume: 46, Issue:4 Topics: Adolescent; Adult; Child; Cyclosporine; Female; Gingiva; Gingival Hyperplasia; Humans; Male; Middle Aged; Neovascularization, Pathologic; Phenytoin	1991
Evaluation of evacuated blood-collection tubes: effects of three types of polymeric separators on therapeutic drug-monitoring specimens. Clinical chemistry, 1993, Volume: 39, Issue:8 Topics: Acrylic Resins; Blood Specimen Collection; Cell Separation; Cyclosporine; Digoxin; Drug Monitoring; Ethanol; Gentamicins; Humans; Phenobarbital; Phenytoin; Polyesters; Polymers; Silicones; Theophylline	1993
The effect of chronic administration of cyclosporin A on phenytoin pharmacokinetic parameters in the rat. Life sciences, 1993, Volume: 52, Issue:2 Topics: Animals; Blood Chemical Analysis; Cyclosporine; Drug Interactions; Injections, Intravenous; Male; Phenytoin; Rats; Rats, Sprague-Dawley	1993
Immunohistochemical distribution of extracellular matrix proteins as a diagnostic parameter in healthy and diseased gingiva. Journal of periodontology, 1993, Volume: 64, Issue:2 Topics: Adult; Aged; Collagen; Cyclosporine; Extracellular Matrix Proteins; Female; Fibronectins; Fluorescent Antibody Technique; Gingiva; Gingival Hyperplasia; Gingivitis; Glycoproteins; Humans; Immunohistochemistry; Male; Microscopy, Fluorescence; Middle Aged; Nifedipine; Phenytoin	1993
Hydroxyproline and total protein levels in gingiva from patients treated with phenytoin and cyclosporine-A. The Journal of Nihon University School of Dentistry, 1996, Volume: 38, Issue:1 Topics: Adult; Age Factors; Anticonvulsants; Collagen; Cyclosporine; Dental Plaque Index; Female; Gingiva; Gingival Hyperplasia; Humans; Hydroxyproline; Male; Periodontal Index; Phenytoin; Protein Biosynthesis	1996
Estimation of the increase in solubility of drugs as a function of bile salt concentration. Pharmaceutical research, 1996, Volume: 13, Issue:1 Topics: Bile Acids and Salts; Chemical Phenomena; Chemistry, Physical; Cholagogues and Choleretics; Cyclosporine; Diazepam; Fasting; Food; Griseofulvin; Intestinal Absorption; Models, Chemical; Pentazocine; Phenytoin; Solubility; Steroids; Taurocholic Acid	1996
Phenytoin and cyclosporine A specifically regulate macrophage phenotype and expression of platelet-derived growth factor and interleukin-1 in vitro and in vivo: possible molecular mechanism of drug-induced gingival hyperplasia. Journal of periodontology, 1997, Volume: 68, Issue:1 Topics: Adult; Animals; Anticonvulsants; Cells, Cultured; Cyclosporine; Enzyme-Linked Immunosorbent Assay; Gingival Hyperplasia; Humans; Immunophenotyping; Immunosuppressive Agents; Interleukin-1; Macrophages; Middle Aged; Phenytoin; Platelet-Derived Growth Factor; Rats; RNA, Messenger	1997
Vigabatrin-induced gingival overgrowth. Journal of clinical periodontology, 1997, Volume: 24, Issue:3 Topics: Adult; Anticonvulsants; Calcium Channel Blockers; Cyclosporine; Epilepsy, Complex Partial; Female; Follow-Up Studies; gamma-Aminobutyric Acid; Gingival Overgrowth; Humans; Immunosuppressive Agents; Phenytoin; Vigabatrin	1997
Case report. Use of an argon laser to treat drug-induced gingival overgrowth. Journal of the American Dental Association (1939), 1998, Volume: 129, Issue:1 Topics: Anticonvulsants; Argon; Calcium Channel Blockers; Candidiasis, Oral; Cyclosporine; Denture, Complete; Diabetes Mellitus, Type 1; Gingival Hyperplasia; Gingivectomy; Humans; Immunosuppressive Agents; Kidney Transplantation; Laser Therapy; Male; Middle Aged; Patient Education as Topic; Phenytoin	1998
Regulation of gingival fibroblast interleukin-6 secretion by cyclosporine A. Journal of periodontology, 1999, Volume: 70, Issue:12 Topics: Anticonvulsants; Bacteria; Calcium Channel Blockers; Cell Division; Cells, Cultured; Cyclosporine; Down-Regulation; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Gingiva; Gingival Overgrowth; Humans; Immunosuppressive Agents; Interleukin-1; Interleukin-6; Nifedipine; Phenytoin; Tumor Necrosis Factor-alpha; Up-Regulation	1999
Phenytoin and cyclosporin A suppress the expression of MMP-1, TIMP-1, and cathepsin L, but not cathepsin B in cultured gingival fibroblasts. Journal of periodontology, 2000, Volume: 71, Issue:6 Topics: Anticonvulsants; Cathepsin B; Cathepsin L; Cathepsins; Cell Division; Cells, Cultured; Cyclosporine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endopeptidases; Enzyme Inhibitors; Enzyme Precursors; Extracellular Matrix; Fibroblasts; Gene Expression Regulation, Enzymologic; Gingiva; Gingival Hyperplasia; Humans; Lysosomes; Matrix Metalloproteinase Inhibitors; Phenytoin; Time Factors; Tissue Inhibitor of Metalloproteinase-1	2000
Connective tissue growth factor in drug-induced gingival overgrowth. Journal of periodontology, 2001, Volume: 72, Issue:7 Topics: Adult; Antibodies; Anticonvulsants; Calcium Channel Blockers; Carrier Proteins; Coloring Agents; Connective Tissue; Connective Tissue Growth Factor; Cyclosporine; Endothelium, Vascular; Epithelium; Female; Fibroblasts; Fibrosis; Gingival Overgrowth; Growth Substances; Humans; Image Processing, Computer-Assisted; Immediate-Early Proteins; Immunoenzyme Techniques; Immunosuppressive Agents; Intercellular Signaling Peptides and Proteins; Leukocytes, Mononuclear; Male; Middle Aged; Mitogens; Neovascularization, Pathologic; Nifedipine; Phenytoin; Platelet Endothelial Cell Adhesion Molecule-1; Statistics, Nonparametric; Transforming Growth Factor beta; Transforming Growth Factor beta1	2001
Use of rapamycin in a transplant patient who developed cyclosporin neurotoxicity. Pediatric nephrology (Berlin, Germany), 2001, Volume: 16, Issue:10 Topics: Anticonvulsants; Child; Cyclosporine; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Graft Rejection; Humans; Immunosuppressive Agents; Kidney Failure, Chronic; Phenytoin; Seizures; Sirolimus	2001
Management of drug-induced gingival enlargement with orthodontic complications. Annals of the Royal Australasian College of Dental Surgeons, 2000, Volume: 15 Topics: Anticonvulsants; Calcium Channel Blockers; Cyclosporine; Dental Plaque; Esthetics, Dental; Feeding and Eating Disorders; Gingival Hypertrophy; Humans; Immunosuppressive Agents; Malocclusion; Patient Care Planning; Patient Care Team; Phenytoin; Speech Disorders	2000
Role of pharmacologic enhancement of p-450 in cyclosporine overdose. Transplantation, 2002, Nov-15, Volume: 74, Issue:9 Topics: Cyclosporine; Cytochrome P-450 Enzyme System; Drug Overdose; Humans; Male; Middle Aged; Phenytoin; Poisoning	2002
Developmental changes in the liver weight- and body weight-normalized clearance of theophylline, phenytoin and cyclosporine in children. International journal of clinical pharmacology and therapeutics, 2002, Volume: 40, Issue:11 Topics: Administration, Oral; Adolescent; Age Factors; Aryl Hydrocarbon Hydroxylases; Body Surface Area; Body Weight; Child; Child, Preschool; Cyclosporine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Infant; Infant, Newborn; Liver; Metabolic Clearance Rate; Mixed Function Oxygenases; Models, Biological; Organ Size; Phenytoin; Theophylline	2002
Persistent anticonvulsant hypersensitivity syndrome responding to ciclosporin. Clinical and experimental dermatology, 2003, Volume: 28, Issue:4 Topics: Adult; Anticonvulsants; Biopsy; Cyclosporine; Dermatologic Agents; Drug Eruptions; Drug Therapy, Combination; Female; Humans; Interleukin-5; Lamotrigine; Phenytoin; Pruritus; Triazines	2003
Aplastic anemia complicating systemic lupus erythematosus: successful management with cyclosporine. Rheumatology international, 2004, Volume: 24, Issue:1 Topics: Adult; Anemia, Aplastic; Cyclophosphamide; Cyclosporine; Female; Humans; Lupus Erythematosus, Systemic; Menorrhagia; Methylprednisolone; Pancytopenia; Phenytoin; Seizures; Treatment Outcome	2004
[Odinophagia and cutaneous lesions in patient with cerebral metastases]. Revista clinica espanola, 2006, Volume: 206, Issue:5 Topics: Aged; Anticonvulsants; Back; Brain Neoplasms; Cyclosporine; Dermis; Epilepsy; Fatal Outcome; Humans; Immunosuppressive Agents; Male; Mouth Mucosa; Necrosis; Phenytoin; Skin Diseases; Stevens-Johnson Syndrome	2006
Immunohistochemical evaluation of Ki-67 expression and apoptosis in cyclosporin A-induced gingival overgrowth. Journal of periodontology, 2007, Volume: 78, Issue:2 Topics: Adult; Analysis of Variance; Apoptosis; Calcium Channel Blockers; Case-Control Studies; Cell Proliferation; Cyclosporine; Female; Gingival Overgrowth; Humans; Immunohistochemistry; Immunosuppressive Agents; In Situ Nick-End Labeling; Ki-67 Antigen; Kidney Transplantation; Male; Mitosis; Nifedipine; Phenytoin; Statistics, Nonparametric	2007
Apoptosis in gingival overgrowth tissues. Journal of dental research, 2007, Volume: 86, Issue:9 Topics: Anticonvulsants; Apoptosis; Calcium Channel Blockers; Case-Control Studies; Caspase 3; Cell Proliferation; Cyclosporine; Fibroblasts; Fibromatosis, Gingival; Forkhead Box Protein O1; Forkhead Transcription Factors; Gingival Overgrowth; Gingivitis; Humans; Immunosuppressive Agents; In Situ Nick-End Labeling; Nifedipine; Phenytoin; Proliferating Cell Nuclear Antigen	2007
Effects of cyclosporin, phenytoin, and nifedipine on the synthesis and degradation of gingival collagen in tufted capuchin monkeys (Cebus apella): histochemical and MMP-1 and -2 and collagen I gene expression analyses. Journal of periodontology, 2008, Volume: 79, Issue:1 Topics: Animals; Anticonvulsants; Azo Compounds; Biopsy; Calcium Channel Blockers; Cebus; Collagen; Collagen Type I; Collagen Type IV; Coloring Agents; Cyclosporine; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Gingiva; Gingival Overgrowth; Gingivitis; Histocytochemistry; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinase 2; Nifedipine; Phenytoin; Random Allocation; Reverse Transcriptase Polymerase Chain Reaction	2008
Increased P-glycoprotein function and level after long-term exposure of four antiepileptic drugs to rat brain microvascular endothelial cells in vitro. Neuroscience letters, 2008, Apr-04, Volume: 434, Issue:3 Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Carbamazepine; Cells, Cultured; Cerebral Arteries; Cyclosporine; Dose-Response Relationship, Drug; Drug Administration Schedule; Endothelial Cells; Immunosuppressive Agents; Indicators and Reagents; Microcirculation; Phenobarbital; Phenytoin; Rats; Rhodamine 123; Sodium Channel Blockers; Time; Up-Regulation; Valproic Acid; Verapamil	2008
Case of the month: drug-induced hyperplasia. Today's FDA : official monthly journal of the Florida Dental Association, 2008, Volume: 20, Issue:3 Topics: Adult; Cyclosporine; Diagnosis, Differential; Female; Gingival Hyperplasia; Humans; Nifedipine; Phenytoin	2008
Cyclosporin A and phenytoin modulate inflammatory responses. Journal of dental research, 2009, Volume: 88, Issue:12 Topics: Animals; Anticonvulsants; Cells, Cultured; CHO Cells; Cricetinae; Cricetulus; Cyclosporine; Down-Regulation; Escherichia coli; Female; Fibroblasts; Gingiva; Gingival Overgrowth; Humans; Immunosuppressive Agents; Intercellular Adhesion Molecule-1; Interleukin-6; Interleukin-8; Lipid A; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Middle Aged; Phenytoin; Signal Transduction; Toll-Like Receptor 2; Toll-Like Receptor 4; Toll-Like Receptors	2009
Novel spray freeze-drying technique using four-fluid nozzle-development of organic solvent system to expand its application to poorly water soluble drugs. Chemical & pharmaceutical bulletin, 2010, Volume: 58, Issue:2 Topics: Acetonitriles; Anticonvulsants; Cyclosporine; Freeze Drying; Immunosuppressive Agents; Particle Size; Pharmaceutical Preparations; Phenytoin; Porosity; Solubility; Water	2010
Loss of basement membrane integrity in human gingival overgrowth. Journal of dental research, 2011, Volume: 90, Issue:7 Topics: Adult; Analysis of Variance; Basement Membrane; Case-Control Studies; Cell Adhesion Molecules; Collagen Type IV; Cyclosporine; Epithelial-Mesenchymal Transition; Female; Gene Expression; Gingival Overgrowth; Humans; Kalinin; Male; Nifedipine; Phenytoin; Statistics, Nonparametric; Young Adult	2011
Application of a systems approach to the bottom-up assessment of pharmacokinetics in obese patients: expected variations in clearance. Clinical pharmacokinetics, 2011, Dec-01, Volume: 50, Issue:12 Topics: Adolescent; Adult; Aged; Benzodiazepines; Body Weights and Measures; Caffeine; Chlorzoxazone; Computer Simulation; Cyclosporine; Female; Gastrointestinal Tract; Humans; Kidney; Liver; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Obesity; Obesity, Morbid; Pharmacokinetics; Phenytoin; Regional Blood Flow; Theophylline; Young Adult	2011
Drug-induced gingival hyperplasia. Prescrire international, 2011, Volume: 20, Issue:122 Topics: Calcium Channel Blockers; Cyclosporine; Gingival Hyperplasia; Humans; Oral Hygiene; Phenytoin	2011
Drug-induced gingival overgrowth: a study in the French Pharmacovigilance Database. Journal of clinical periodontology, 2012, Volume: 39, Issue:6 Topics: Adolescent; Adult; Aged; Anticonvulsants; Calcium Channel Blockers; Child; Child, Preschool; Cyclosporine; Databases, Factual; Female; France; Gingival Overgrowth; Humans; Immunosuppressive Agents; Infant; Male; Middle Aged; Pharmacovigilance; Phenytoin; Treatment Outcome; Young Adult	2012
Oral pathology quiz # 75. Case number 4. Systemic medication. Journal of the New Jersey Dental Association, 2012,Spring, Volume: 83, Issue:2 Topics: Anticonvulsants; Cyclosporine; Diagnosis, Differential; Gingival Hyperplasia; Humans; Immunosuppressive Agents; Male; Middle Aged; Nifedipine; Phenytoin; Vasodilator Agents	2012
Prediction of clinically relevant safety signals of nephrotoxicity through plasma metabolite profiling. BioMed research international, 2013, Volume: 2013 Topics: Animals; Captopril; Cyclosporine; Doxorubicin; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Kidney Diseases; Lisinopril; Male; Metabolome; Metabolomics; Phenytoin; Rats; Rats, Wistar	2013
Effects of cyclosporine and phenytoin on biomarker expressions in gingival fibroblasts of children and adults: an in vitro study. Journal of basic and clinical physiology and pharmacology, 2014, May-01, Volume: 25, Issue:2 Topics: Adult; Age Factors; Biomarkers; Cell Culture Techniques; Cells, Cultured; Child; Cyclosporine; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Gene Expression; Gingiva; Gingival Overgrowth; Humans; Phenytoin	2014
Biological roles of KGF, CTGF and TGF-β in cyclosporine-A- and phenytoin- induced gingival overgrowth: A comparative experimental animal study. Archives of oral biology, 2016, Volume: 66 Topics: Animals; Connective Tissue Growth Factor; Cyclosporine; Disease Models, Animal; Epithelium; Fibroblast Growth Factor 7; Fibroblasts; Gingiva; Gingival Overgrowth; Male; Phenytoin; Random Allocation; Rats; Transforming Growth Factor beta	2016
Topical application of phenytoin or nifedipine-loaded PLGA microspheres promotes periodontal regeneration in vivo. Archives of oral biology, 2019, Volume: 97 Topics: Administration, Topical; Alveolar Bone Loss; Animals; Biomarkers; Cyclosporine; Drug Carriers; Gingival Recession; Immunohistochemistry; Male; Microspheres; Nifedipine; Phenytoin; Polyesters; Random Allocation; Rats; Rats, Sprague-Dawley; Single-Blind Method; X-Ray Microtomography	2019
Effects of cyclosporin, nifedipine and phenytoin on gingival myofibroblast transdifferentiation in monkeys. Journal of applied oral science : revista FOB, 2018, Nov-08, Volume: 27 Topics: Actins; Animals; Apoptosis; Biopsy; Cell Proliferation; Cell Transdifferentiation; Cyclosporine; Genes, bcl-2; Gingiva; Gingival Overgrowth; Haplorhini; Immunohistochemistry; Ki-67 Antigen; Longitudinal Studies; Male; Myofibroblasts; Nifedipine; Phenytoin; Random Allocation	2018