phenytoin and cimetidine

phenytoin has been researched along with cimetidine in 66 studies

Research

Studies (66)

Timeframe	Studies, this research(%)	All Research%
pre-1990	28 (42.42)	18.7374
1990's	10 (15.15)	18.2507
2000's	12 (18.18)	29.6817
2010's	16 (24.24)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET	1
Topliss, JG; Yoshida, F	1
Faller, B; Wohnsland, F	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Campillo, NE; Guerra, A; Páez, JA	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Al-Kawas, FH; Lenes, BA; Sacher, RA	1
Bircher, J; Brandes, A; Compagnone, D; Hille, H; Münch, B; Ullrich, D	1
Hsieh, CY; Huang, JD	1
Ishida, M; Kondo, S; Maeba, T; Maeda, A	1
Kim, C	1
Bantle, JA; Fort, DJ	1
Chremos, AN; Lin, ET; Sambol, NC; Upton, RA; Williams, RL	1
Baciewicz, AM	1
Debreczeni, LA; Herjavecz, I; Szeitz, A	1
Hsieh, YY; Huang, JD; Kwan, EC; Lai, ML; Lin, MS; Liu, RT	1
Chan, KH; Mann, KS; Yue, CP	1
Brown, FD; Lichtor, T; Wong, YY	1
Hansky, J; Phillips, P	1
Abita, JP; Gespach, C	1
Darvey, DL; Sorkin, EM	1
Greene, W	1
Feely, J	1
Williams, KM	1
DiPiro, JT; Griffin, JW; May, JR	1
Buchheit, WA; Rosenwasser, RH; Truex, RC	1
Caravaggi, M; Crema, A; D'Angelo, L; Frigo, GM; Gatti, G; Lecchini, S; Perucca, E; Tonini, M	1
Hino, T; Ito, Y; Kunieda, T; Ohashi, H; Sakata, K; Tsuchiya, J	1
Bochner, F; Hallpike, JF; Hann, CS; Hetzel, DJ; Shearman, DJ	1
Kaste, M; Neuvonen, PJ; Tokola, R	1
D'Arcy, PF	1
Bartle, WR; Shapero, T; Walker, SE	1
Breland, BD; Jordan, JE; Mishra, SK; Salem, RB	1
Jenike, MA	1
Algozzine, GJ; Springer, PK; Stewart, RB	1
Babb, RR	1
Kaste, M; Neuvonen, PJ; Tokola, RA	1
Jaffe, JP; Sazie, E	1
Bachmann, KA; Jauregui, L; Levine, L; Miller, K; Reese, J; Sullivan, TJ	1
Amabeoku, GJ; Chikuni, O	1
Arbiser, JL; Goldstein, AM; Gordon, D	1
Dempsey, RJ; Hatton, J; Lu, WY; Rhoney, DH; Tibbs, PA; Young, B	1
Hirayama, F; Iizumi, Y; Kawasaki, T; Koshio, H; Matsumoto, Y; Sato, K; Taniuchi, Y	1
Feely, J; Kelly, A; Williams, D	1
Kou, JH; Saha, P	1
Brox, S; Küster, E; Reemtsma, T; Ritter, AP	1
Zhang, T	1
Barczyński, B; Czuczwar, SJ; Świąder, K; Świąder, MJ; Tomaszewski, M	1

Reviews

6 review(s) available for phenytoin and cimetidine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Carbamazepine drug interactions. Therapeutic drug monitoring, 1986, Volume: 8, Issue:3 Topics: Carbamazepine; Cimetidine; Dextropropoxyphene; Drug Interactions; Erythromycin; Humans; Isoniazid; Lithium; Phenobarbital; Phenytoin; Primidone; Protein Binding; Troleandomycin; Valproic Acid; Warfarin	1986
Review of cimetidine drug interactions. Drug intelligence & clinical pharmacy, 1983, Volume: 17, Issue:2 Topics: Adrenergic beta-Antagonists; Animals; Anti-Anxiety Agents; Anti-Bacterial Agents; Benzodiazepines; Cimetidine; Diet; Drug Interactions; Glucose; Guanidines; Histamine H1 Antagonists; Humans; Imidazoles; Insulin; Ketoconazole; Metoclopramide; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Phenytoin; Piperazines; Propantheline	1983
Drug interactions involving cimetidine--mechanisms, documentation, implications. Quarterly reviews on drug metabolism and drug interactions, 1984, Volume: 5, Issue:1 Topics: Acetaminophen; Adrenergic beta-Antagonists; Analgesics, Opioid; Animals; Antacids; Anti-Anxiety Agents; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Anticoagulants; Anticonvulsants; Antifungal Agents; Aspirin; Benzodiazepines; Cimetidine; Digoxin; Drug Interactions; Humans; Intestinal Absorption; Iron; Lidocaine; Pancreas; Phenytoin; Prednisolone; Theophylline; Vitamin B 12	1984
Interaction of cimetidine with other drugs. Southern medical journal, 1983, Volume: 76, Issue:6 Topics: Aged; Chlormethiazole; Cimetidine; Diazepam; Drug Interactions; Guanidines; Humans; Lidocaine; Liver; Liver Circulation; Phenytoin; Propranolol; Tissue Distribution; Warfarin	1983
Cimetidine in elderly patients: review of uses and risks. Journal of the American Geriatrics Society, 1982, Volume: 30, Issue:3 Topics: Administration, Oral; Aged; Antacids; Chemical Phenomena; Chemistry; Chlordiazepoxide; Cimetidine; Diazepam; Drug Interactions; Duodenal Ulcer; Female; Gastric Acid; Guanidines; Humans; Mental Disorders; Middle Aged; Peptic Ulcer; Phenytoin; Zollinger-Ellison Syndrome	1982

Trials

2 trial(s) available for phenytoin and cimetidine

Article	Year
A comparison of the influence of famotidine and cimetidine on phenytoin elimination and hepatic blood flow. British journal of clinical pharmacology, 1989, Volume: 27, Issue:1 Topics: Cimetidine; Cytochrome P-450 Enzyme System; Drug Evaluation; Famotidine; Female; Histamine H2 Antagonists; Humans; Indocyanine Green; Liver Circulation; Male; Phenytoin; Random Allocation; Thiazoles	1989
Dose-dependent effect of cimetidine on phenytoin kinetics. Clinical pharmacology and therapeutics, 1983, Volume: 33, Issue:5 Topics: Adult; Chromatography, High Pressure Liquid; Cimetidine; Dose-Response Relationship, Drug; Drug Evaluation; Drug Interactions; Guanidines; Humans; Kinetics; Male; Phenytoin; Random Allocation	1983

Other Studies

58 other study(ies) available for phenytoin and cimetidine

Article	Year
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. Journal of medicinal chemistry, 1985, Volume: 28, Issue:3 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium	1985
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes. Journal of medicinal chemistry, 2001, Mar-15, Volume: 44, Issue:6 Topics: Alkanes; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Octanols; Permeability; Pharmaceutical Preparations; Solubility; Water	2001
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:2 Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols	2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
Cimetidine and agranulocytosis. Annals of internal medicine, 1979, Volume: 90, Issue:6 Topics: Aged; Agranulocytosis; Cimetidine; Drug Synergism; Female; Guanidines; Humans; Phenytoin	1979
Urinary caffeine metabolites in man. Age-dependent changes and pattern in various clinical situations. European journal of clinical pharmacology, 1992, Volume: 43, Issue:2 Topics: Adolescent; Adult; Age Factors; Allopurinol; Caffeine; Child; Cimetidine; Drug Interactions; Female; Humans; Kidney Failure, Chronic; Liver Cirrhosis; Male; Phenytoin; Smoking; Theophylline	1992
Two-dimensional high-performance liquid chromatographic method to assay p-hydroxyphenylphenylhydantoin enantiomers in biological fluids and stereoselectivity of enzyme induction in phenytoin metabolism. Journal of chromatography, 1992, Mar-13, Volume: 575, Issue:1 Topics: Acetone; Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Chromatography, High Pressure Liquid; Cimetidine; Dexamethasone; Diazepam; Enzyme Induction; Female; Ketoconazole; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Phenytoin; Rats; Safrole; Sex Characteristics; Stereoisomerism; Sulfaphenazole	1992
[Acute renal failure associated with miscellaneous drugs]. Nihon rinsho. Japanese journal of clinical medicine, 1991, Volume: 49, Issue:6 Topics: Acute Kidney Injury; Angiotensin-Converting Enzyme Inhibitors; Cimetidine; Furosemide; Humans; Lithium; Lovastatin; Mannitol; Methoxyflurane; Phenytoin; Rhabdomyolysis	1991
Dilantin toxicity and depression. Archives of physical medicine and rehabilitation, 1990, Volume: 71, Issue:12 Topics: Cimetidine; Depression; Drug Administration Schedule; Drug Interactions; Humans; Phenytoin	1990
Use of Frog Embryo Teratogenesis Assay-Xenopus and an exogenous metabolic activation system to evaluate the developmental toxicity of diphenylhydantoin. Fundamental and applied toxicology : official journal of the Society of Toxicology, 1990, Volume: 14, Issue:4 Topics: Abnormalities, Drug-Induced; Animals; Biotransformation; Cimetidine; Cyclohexanes; Cyclohexenes; Dose-Response Relationship, Drug; Ellipticines; Epoxide Hydrolases; Female; Male; Methods; Microsomes, Liver; Mixed Function Oxygenases; Phenytoin; Pregnancy; Ranidae; Rats; Rats, Inbred Strains; Xenopus	1990
Effects of drugs on aminophylline elimination in rats. Arzneimittel-Forschung, 1988, Volume: 38, Issue:12 Topics: Aminophylline; Animals; Behavior, Animal; Carbamazepine; Cimetidine; Drug Combinations; Drug Interactions; Erythromycin; Female; Half-Life; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Rifampin; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination	1988
The complexity of cimetidine-phenytoin interaction. Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association, 1986, Volume: 85, Issue:4 Topics: Adult; Cimetidine; Drug Interactions; Female; Humans; Intestinal Absorption; Kinetics; Male; Metabolic Clearance Rate; Middle Aged; Phenytoin	1986
Severe thrombocytopenia due to combined cimetidine and phenytoin therapy. Neurosurgery, 1987, Volume: 20, Issue:6 Topics: Adult; Aged; Bone Marrow Diseases; Cimetidine; Humans; Male; Phenytoin; Thrombocytopenia	1987
Severe thrombocytopenia associated with phenytoin and cimetidine therapy. Surgical neurology, 1985, Volume: 23, Issue:2 Topics: Aged; Cimetidine; Humans; Male; Phenytoin; Thrombocytopenia	1985
Phenytoin toxicity secondary to cimetidine administration. The Medical journal of Australia, 1984, Oct-27, Volume: 141, Issue:9 Topics: Aged; Cimetidine; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Humans; Peptic Ulcer; Phenytoin; Ranitidine	1984
Human polymorphonuclear neutrophils. Pharmacological characterization of histamine receptors mediating the elevation of cyclic AMP. Molecular pharmacology, 1982, Volume: 21, Issue:1 Topics: Cimetidine; Cyclic AMP; Histamine; Humans; In Vitro Techniques; Neutrophils; Phenytoin; Phosphodiesterase Inhibitors; Receptors, Histamine; Receptors, Histamine H1; Receptors, Histamine H2; Somatostatin; Time Factors	1982
Kinetics of misonidazole enantiomers. Clinical pharmacology and therapeutics, 1984, Volume: 36, Issue:6 Topics: Administration, Oral; Adult; Cimetidine; Drug Interactions; Female; Half-Life; Humans; Kinetics; Male; Misonidazole; Nitroimidazoles; Phenobarbital; Phenytoin; Stereoisomerism	1984
Drug interactions: theory versus practice. The American journal of medicine, 1984, Nov-19, Volume: 77, Issue:5B Topics: Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Drug Interactions; Drug Therapy, Combination; Humans; Phenytoin; Retrospective Studies; Theophylline; Time Factors	1984
Management of subarachnoid hemorrhage. Pennsylvania medicine, 1984, Volume: 87, Issue:12 Topics: Adolescent; Adult; Aminocaproic Acid; Antihypertensive Agents; Child; Cimetidine; Dexamethasone; Humans; Intracranial Pressure; Ischemic Attack, Transient; Phenobarbital; Phenytoin; Subarachnoid Hemorrhage	1984
Reduction of phenytoin clearance caused by cimetidine. European journal of clinical pharmacology, 1983, Volume: 25, Issue:1 Topics: Adult; Cimetidine; Drug Interactions; Female; Half-Life; Humans; Infusions, Parenteral; Kinetics; Male; Phenytoin	1983
Stress ulcer accompanying subarachnoid hemorrhage--a new rat model. The Japanese journal of surgery, 1983, Volume: 13, Issue:4 Topics: Animals; Cimetidine; Diazepam; Disease Models, Animal; Gastric Mucosa; Male; Pentobarbital; Phenytoin; Rats; Rats, Inbred Strains; Stomach Ulcer; Stress, Physiological; Subarachnoid Hemorrhage	1983
Cimetidine interaction with phenytoin. British medical journal (Clinical research ed.), 1981, May-09, Volume: 282, Issue:6275 Topics: Adult; Cimetidine; Drug Interactions; Epilepsy; Guanidines; Humans; Middle Aged; Phenytoin	1981
Cimetidine interaction with phenytoin. British medical journal (Clinical research ed.), 1981, Aug-15, Volume: 283, Issue:6289 Topics: Cimetidine; Drug Interactions; Guanidines; Humans; Phenytoin	1981
Early reports on drug interactions. Drug intelligence & clinical pharmacy, 1983, Volume: 17, Issue:2 Topics: Acetaminophen; Amiodarone; Apazone; Aspirin; Carbamazepine; Chlordiazepoxide; Cimetidine; Coumarins; Drug Interactions; Erythromycin; Ethanol; Furosemide; Gentamicins; Humans; Levodopa; Lidocaine; Phenytoin; Prenylamine; Quinidine	1983
Effect of cimetidine on phenytoin serum levels. Epilepsia, 1983, Volume: 24, Issue:3 Topics: Cimetidine; Drug Synergism; Epilepsy; Guanidines; Humans; Male; Phenytoin	1983
Decreased clearance of phenytoin with cimetidine. Annals of internal medicine, 1981, Volume: 95, Issue:2 Topics: Adult; Cimetidine; Drug Interactions; Female; Guanidines; Humans; Phenytoin	1981
Drug interactions with cimetidine. Postgraduate medicine, 1981, Volume: 70, Issue:5 Topics: Chlordiazepoxide; Cimetidine; Diazepam; Drug Interactions; Guanidines; Humans; Phenytoin; Propranolol; Theophylline; Warfarin	1981
Cimetidine-phenytoin interaction: effect on serum phenytoin concentration and antipyrine test. European journal of clinical pharmacology, 1981, Volume: 21, Issue:3 Topics: Adult; Aged; Antipyrine; Cimetidine; Drug Interactions; Female; Guanidines; Humans; Kinetics; Male; Middle Aged; Phenytoin; Prospective Studies	1981
Severe granulocytopenia with cimetidine and phenytoin. Annals of internal medicine, 1980, Volume: 93, Issue:1 Topics: Adolescent; Agranulocytosis; Cimetidine; Drug Interactions; Guanidines; Humans; Male; Phenytoin	1980
Drug interactions of H2-receptor antagonists. Scandinavian journal of gastroenterology. Supplement, 1994, Volume: 206 Topics: Adolescent; Adult; Aged; Antacids; Biological Availability; Cimetidine; Drug Interactions; Famotidine; Histamine H2 Antagonists; Humans; Middle Aged; Nizatidine; Omeprazole; Phenytoin; Ranitidine; Theophylline	1994
Cimetidine-induced seizures in mice. Antagonism by some GABAergic agents. Biochemical pharmacology, 1993, Dec-14, Volume: 46, Issue:12 Topics: Aminobutyrates; Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; Cimetidine; Diazepam; Female; Mice; Muscimol; Phenobarbital; Phenytoin; Picrotoxin; Receptors, GABA; Seizures; Strychnine	1993
Thrombocytopenia following administration of phenytoin, dexamethasone and cimetidine: a case report and a potential mechanism. Journal of internal medicine, 1993, Volume: 234, Issue:1 Topics: Aged; Aged, 80 and over; Cimetidine; Dexamethasone; Drug Interactions; Female; Humans; Phenytoin; Thrombocytopenia	1993
A step-wise protocol for stress ulcer prophylaxis in the neurosurgical intensive care unit. Surgical neurology, 1996, Volume: 46, Issue:5 Topics: Adult; Cimetidine; Clinical Protocols; Critical Care; Drug Therapy, Combination; Gastric Acid; Gastroscopy; Humans; Hydrogen-Ion Concentration; Length of Stay; Middle Aged; Neurosurgery; Peptic Ulcer; Phenytoin; Prospective Studies; Risk Factors; Stress, Physiological; Thrombocytopenia; Trauma, Nervous System; Wounds, Nonpenetrating; Wounds, Penetrating	1996
Comparison of the anticoagulant and antithrombotic effects of YM-75466, a novel orally-active factor Xa inhibitor, and warfarin in mice. Japanese journal of pharmacology, 1998, Volume: 78, Issue:2 Topics: Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents; Anticoagulants; Anticonvulsants; Antifibrinolytic Agents; Blood Coagulation; Carbamazepine; Cimetidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Erythromycin; Factor Xa Inhibitors; Fibrinolytic Agents; Hemorrhage; Male; Mice; Mice, Inbred ICR; Partial Thromboplastin Time; Phenytoin; Piperidines; Prothrombin Time; Rifampin; Sulfonamides; Thromboembolism; Thromboplastin; Vitamin K 1; Warfarin	1998
Drug interactions avoided-a useful indicator of good prescribing practice. British journal of clinical pharmacology, 2000, Volume: 49, Issue:4 Topics: Anticoagulants; Anticonvulsants; Cimetidine; Drug Interactions; Drug Prescriptions; Histamine H2 Antagonists; Humans; Ireland; Odds Ratio; Phenytoin; Theophylline; Vasodilator Agents; Warfarin	2000
Effect of solubilizing excipients on permeation of poorly water-soluble compounds across Caco-2 cell monolayers. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2000, Volume: 50, Issue:3 Topics: Alkaloids; Biological Transport; Caco-2 Cells; Cell Membrane Permeability; Cimetidine; Diltiazem; Excipients; Furans; Humans; Hydrogen-Ion Concentration; Imidazoles; Intestinal Absorption; Naphthalenes; Phenytoin; Piperidines; Poloxamer; Polyethylene Glycols; Povidone; Propranolol; Solubility; Triazoles	2000
A quantitative HPLC-MS/MS method for studying internal concentrations and toxicokinetics of 34 polar analytes in zebrafish (Danio rerio) embryos. Analytical and bioanalytical chemistry, 2014, Volume: 406, Issue:20 Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Atropine; Chromatography, High Pressure Liquid; Cimetidine; Embryo, Nonmammalian; Metoprolol; Pesticides; Pharmaceutical Preparations; Phenytoin; Tandem Mass Spectrometry; Toxicokinetics; Water Pollutants, Chemical; Zebrafish	2014
Physiologically based pharmacokinetic modeling of disposition and drug-drug interactions for atorvastatin and its metabolites. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2015, Sep-18, Volume: 77 Topics: Area Under Curve; Atorvastatin; Cimetidine; Clarithromycin; Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Itraconazole; Models, Biological; Phenytoin; Rifampin	2015
The effects of cimetidine chronic treatment on conventional antiepileptic drugs in mice. Pharmacological reports : PR, 2016, Volume: 68, Issue:2 Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Cimetidine; Drug Interactions; Electroshock; Male; Memory, Long-Term; Mice; Phenobarbital; Phenytoin; Seizures; Valproic Acid	2016