phenytoin and caffeine

phenytoin has been researched along with caffeine in 98 studies

Research

Studies (98)

Timeframe	Studies, this research(%)	All Research%
pre-1990	49 (50.00)	18.7374
1990's	12 (12.24)	18.2507
2000's	16 (16.33)	29.6817
2010's	16 (16.33)	24.3611
2020's	5 (5.10)	2.80

Authors

Authors	Studies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET	1
Duffy, EM; Jorgensen, WL	1
Topliss, JG; Yoshida, F	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Jolivette, LJ; Ward, KW	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Campillo, NE; Guerra, A; Páez, JA	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Akamatsu, M	1
Boriss, H; Braggio, S; Corbioli, S; Fontana, S; Helmdach, L; Longhi, R; Schiller, J; Vinco, F	1
Sen, S; Sinha, N	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Honda, K; Izumi, T; Miyaji, Y; Nakayama, S; Okazaki, O; Okudaira, N; Shiosakai, K; Sugiyama, D; Suzuki, W; Takakusa, H; Watanabe, A	1
Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Behnam, MAM; Bock, J; Graf, D; Klein, CD; Kühl, N; Leuthold, MM	1
Behnam, MAM; Klein, CD; Kühl, N; Leuthold, MM	1
Chłoń-Rzepa, G; Dąbrowska, M; Jankowska, A; Komsta, Ł; Pawłowski, M; Ślusarczyk, M; Starek, M; Zagórska, A	1
Haefely, W; Jalfre, M; Ruch-Monachon, MA	1
Asai, S; Kubodera, T; Nadai, T; Tatematsu, A; Yoshizumi, H	1
Hanson, HM; Ivester, CA; Morton, BR	1
Brown, L; Horning, MG; Kellaway, P; Lertratanangkoon, K; Nowlin, J; Zion, TE	1
Karmen, A; Lehrer, M	1
Butler, CM; Hill, RM; Horning, MG; Howlin, J	1
Butler, CM; Hill, RM; Horning, MG; Lertratanangkoon, K; Nowlin, J; Sommer, K	1
Bircher, J; Brandes, A; Compagnone, D; Hille, H; Münch, B; Ullrich, D	1
Dean, PM; Edwardson, JM	1
Beech, J; Fletcher, JE; Rosenberg, H	1
Røed, A	1
Haginaka, J; Kimura, Y; Wakai, J; Yasuda, H	1
Baty, C; Jambou, J; Leducq, B; Richard, L	1
Büchsel, R; Kohl, D; Kreiten, K; Matern, S; Wietholtz, H; Zysset, T	1
Katayama, T; Kato, N; Kusuhara, T; Ohara, K; Ohchi, H	1
Marazzi, A; Randriamiharisoa, A; Ruffieux, C	1
Gerber, N; Hilliard, JB; Mays, DC; Nawoot, S; Pacula, CM	1
Bonati, M; Bortolotti, A; Jiritano, L	1
Clodi, PH; Hartl, O	1
Bounameaux, Y	1
Pedersen, KO	1
Greengard, P; Quinn, GP; Reid, MB	1
Oswald, I	1
Bittar, EE; Hift, H; Huddart, H; Tong, E	1
Dryden, EE; Manery, JF; Woo, YT	1
Papini, M; Zappoli, R	1
Oldendorf, WH	1
Izquierdo, I	1
Falk, M; Fürst, W	1
Vorherr, H	1
Hill, RM; Horning, MG; Lertratanangkoon, K; Nowlin, J; Stillwell, RN; Stillwell, WG	1
Fanuele, G; Rossi, U	1
von Albert, HH	1
Hutchins, DA; Rogers, KJ	1
Binns, PM; Ericsson, AD; Meyer, JS; Vulpe, M	1
Burba, JV	1
Barnett, HJ; Richards, RN	1
Guillory, JK; Hwang, SC; Lach, JL	1
Wiedemann, DH	1
Anderson, SM; Daly, JW; Padgett, W; Weir, RL	1
Bukowskyj, M; Munt, PW; Nakatsu, K	1
Chung, LW; Simpson, VJ	1
Kwasigroch, TE; Poche, PD; Skalko, RG	1
Kwasigroch, TE; Skalko, RG	1
Chaput de Saintonge, DM; Hong, CY; Turner, P	1
Beech, J; Dawso, T; Fletcher, JE; Lindborg, S; Tripolitis, L	1
Ishikawa, A; Misawa, S; Tanaka, E	1
Ishide, N	1
Bradbury, A; Houston, JB; Worboys, PD	2
Gibson, GG; Goldfarb, PS; Gray, TJ; Ogg, MS; Tarbit, M; Williams, JM	1
Abel, R; Alvey, CW; Bron, NJ; Hounslow, NJ; Koup, JR; Randinitis, EJ; Rausch, G; Sedman, AJ; Vassos, AB	1
Bi, K; Dai, R; Luo, X; Wang, X	1
GABKA, J	1
SCHNEIDER, E	1
EYSOLD, R	1
JACOBZINER, H; RAYBIN, HW	1
HIRSCHMANN, J	1
GRANT, WM; PECZON, JD	1
BAROLIN, GS; RUPPRECHT, A	1
VOGT, U	1
Abbaspour, A; Mirzajani, R	1
Blaauboer, B; Forsby, A	1
Błaszczyk, B; Chrościńska-Krawczyk, M; Czuczwar, SJ; Jankiewicz, K	1
Budha, NR; Christensen, ML; Mehrotra, N; Meibohm, B; Zhang, Y	1
Aarabi, M; Allabi, AC; Almond, LM; Ghobadi, C; Jamei, M; Johnson, TN; Rostami-Hodjegan, A; Rowland-Yeo, K	1
Dimpfel, W	1
Araújo, DB; Azevedo, JEC; Barbas, LAL; da Silva, ALM; Hamoy, AO; Hamoy, M; Lopes, DCF; Lopez, MEC; Mello, VJ; Nascimento, CP; Pereira, RG; Rodrigues, SF; Vieira, LR	1
Anilanmert, B; Caglar-Andac, S; Narin, I	1

Reviews

8 review(s) available for phenytoin and caffeine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Drug metabolism in the human neonate. Life sciences, 1975, Mar-01, Volume: 16, Issue:5 Topics: Adult; Animals; Barbiturates; Caffeine; Epoxy Compounds; Female; Humans; Infant, Newborn; Labor, Obstetric; Lactation; Maternal-Fetal Exchange; Meperidine; Milk; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Placenta; Pregnancy; Time Factors	1975
Drugs and sleep. Pharmacological reviews, 1968, Volume: 20, Issue:4 Topics: Aminobutyrates; Amphetamine; Animals; Antidepressive Agents; Barbiturates; Caffeine; Cats; Clinical Trials as Topic; Dihydroxyphenylalanine; Dreams; Drug Utilization; Ethanol; Hormones; Humans; Hydroxybutyrates; Hypnotics and Sedatives; Lysergic Acid Diethylamide; Methods; Monoamine Oxidase Inhibitors; Morphine; Nicotine; Parasympatholytics; Parasympathomimetics; Phenytoin; Rats; Reserpine; Sleep; Sleep, REM; Tranquilizing Agents; Tryptophan	1968
Drug excretion in breast milk. Postgraduate medicine, 1974, Volume: 56, Issue:4 Topics: Anti-Bacterial Agents; Barbiturates; Biological Transport, Active; Breast; Breast Feeding; Caffeine; Chloramphenicol; Contraceptives, Oral; Coumarins; Female; Fluorine; Humans; Hydrogen-Ion Concentration; Infant; Infant, Newborn; Infant, Premature, Diseases; Jaundice, Neonatal; Lactation; Meprobamate; Milk, Human; Models, Biological; Morphine; Nicotine; Pesticides; Pharmaceutical Preparations; Phenytoin; Potassium Iodide; Pregnancy; Salicylates; Sulfonamides; Time Factors	1974
Theophylline reassessed. Annals of internal medicine, 1984, Volume: 101, Issue:1 Topics: Acidosis; Aging; Allopurinol; Animals; Anti-Bacterial Agents; Breast Feeding; Bronchodilator Agents; Caffeine; Contraceptives, Oral; Cooking; Cystic Fibrosis; Drug Interactions; Erythromycin; Female; Heart Diseases; Histamine H2 Antagonists; Humans; Hypoxia; Infections; Kinetics; Liver Diseases; Lung Diseases, Obstructive; Maternal-Fetal Exchange; Phenobarbital; Phenytoin; Pregnancy; Respiration Disorders; Sleep; Smoking; Theophylline	1984
Intracellular calcium modulators for cardiac muscle in pathological conditions. Japanese heart journal, 1996, Volume: 37, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Anticonvulsants; Arrhythmias, Cardiac; Benzothiazoles; Caffeine; Calcium; Calcium Channel Blockers; Dantrolene; Flunarizine; Homeostasis; Humans; Magnesium; Models, Cardiovascular; Muscle Relaxants, Central; Myocardial Contraction; Myocardium; Phenytoin; Piperidines; Ryanodine; Sarcoplasmic Reticulum; Thiazepines; Thiazoles	1996
SEDATIVES, STIMULANTS, AND INTRAOCULAR PRESSURE IN GLAUCOMA. Archives of ophthalmology (Chicago, Ill. : 1960), 1964, Volume: 72 Topics: Anticonvulsants; Barbiturates; Caffeine; Central Nervous System Stimulants; Dextroamphetamine; Glaucoma; Hydantoins; Hypnotics and Sedatives; Intraocular Pressure; Meperidine; Mephenesin; Meprobamate; Methamphetamine; Methylphenidate; Paraldehyde; Pentobarbital; Pharmacology; Phenytoin; Primidone; Promethazine; Reserpine; Tonometry, Ocular; Tranquilizing Agents	1964
[Caffeine and antiepileptic drugs: experimental and clinical data]. Przeglad lekarski, 2007, Volume: 64, Issue:11 Topics: Animals; Anticonvulsants; Caffeine; Carbamazepine; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Humans; Lamotrigine; Mice; Nipecotic Acids; Phenobarbital; Phenytoin; Seizures; Tiagabine; Triazines; Valproic Acid	2007

Trials

3 trial(s) available for phenytoin and caffeine

Article	Year
Drugs and sleep. Pharmacological reviews, 1968, Volume: 20, Issue:4 Topics: Aminobutyrates; Amphetamine; Animals; Antidepressive Agents; Barbiturates; Caffeine; Cats; Clinical Trials as Topic; Dihydroxyphenylalanine; Dreams; Drug Utilization; Ethanol; Hormones; Humans; Hydroxybutyrates; Hypnotics and Sedatives; Lysergic Acid Diethylamide; Methods; Monoamine Oxidase Inhibitors; Morphine; Nicotine; Parasympatholytics; Parasympathomimetics; Phenytoin; Rats; Reserpine; Sleep; Sleep, REM; Tranquilizing Agents; Tryptophan	1968
[Therapy of epilepsy in childhood. Clinical testing of a new combination of drugs]. La Pediatria, 1969, Volume: 77, Issue:1 Topics: Barbiturates; Caffeine; Child; Child, Preschool; Clinical Trials as Topic; Epilepsy, Temporal Lobe; Female; Humans; Infant; Male; Phenylbutazone; Phenytoin	1969
Drug interactions with clinafloxacin. Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:9 Topics: Adult; Aged; Anti-Infective Agents; Anticonvulsants; Caffeine; Cytochrome P-450 Enzyme Inhibitors; Drug Interactions; Female; Fluoroquinolones; Humans; Male; Middle Aged; Phenytoin; Theophylline; Warfarin	2001

Other Studies

88 other study(ies) available for phenytoin and caffeine

Article	Year
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. Journal of medicinal chemistry, 1985, Volume: 28, Issue:3 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium	1985
Prediction of drug solubility from Monte Carlo simulations. Bioorganic & medicinal chemistry letters, 2000, Jun-05, Volume: 10, Issue:11 Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility	2000
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. Journal of pharmaceutical sciences, 2005, Volume: 94, Issue:7 Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution	2005
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
QSAR study on permeability of hydrophobic compounds with artificial membranes. Bioorganic & medicinal chemistry, 2007, Jun-01, Volume: 15, Issue:11 Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship	2007
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Importance of physicochemical properties for the design of new pesticides. Journal of agricultural and food chemistry, 2011, Apr-13, Volume: 59, Issue:7 Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic	2011
Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2 Topics: Absorption; Albumins; Animals; Brain; Brain Chemistry; Cell Membrane; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; In Vitro Techniques; Lipids; Male; Microdialysis; Pharmaceutical Preparations; Protein Binding; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine; Tissue Distribution	2011
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. European journal of medicinal chemistry, 2011, Volume: 46, Issue:2 Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:7 Topics: Glutathione; Pharmacology; Sulfur Radioisotopes	2011
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:2 Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols	2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
A New Class of Dengue and West Nile Virus Protease Inhibitors with Submicromolar Activity in Reporter Gene DENV-2 Protease and Viral Replication Assays. Journal of medicinal chemistry, 2020, 08-13, Volume: 63, Issue:15 Topics: Animals; Chlorocebus aethiops; Dengue Virus; Dose-Response Relationship, Drug; Genes, Reporter; HeLa Cells; Humans; Protease Inhibitors; Vero Cells; Virus Replication; West Nile virus	2020
Beyond Basicity: Discovery of Nonbasic DENV-2 Protease Inhibitors with Potent Activity in Cell Culture. Journal of medicinal chemistry, 2021, 04-22, Volume: 64, Issue:8 Topics: Animals; Benzamides; Cell Survival; Dengue Virus; Drug Stability; Genes, Reporter; HeLa Cells; Humans; Microsomes, Liver; Protease Inhibitors; Rats; Small Molecule Libraries; Structure-Activity Relationship; Viral Nonstructural Proteins; Virus Replication	2021
Estimation of the lipophilicity of purine-2,6-dione-based TRPA1 antagonists and PDE4/7 inhibitors with analgesic activity. Bioorganic & medicinal chemistry letters, 2021, 10-01, Volume: 49 Topics: Analgesics; Benzeneacetamides; Cyclic Nucleotide Phosphodiesterases, Type 7; Hydrophobic and Hydrophilic Interactions; Molecular Structure; Phenylbutyrates; Phosphodiesterase 4 Inhibitors; Principal Component Analysis; Quantitative Structure-Activity Relationship; TRPA1 Cation Channel; Xanthines	2021
Drugs and PGO waves in the lateral geniculate body of the curarized cat. V. Miscellaneous compounds. Synopsis of the role of central neurotransmitters on PGO wave activity. Archives internationales de pharmacodynamie et de therapie, 1976, Volume: 219, Issue:2 Topics: Amantadine; Analgesics, Opioid; Animals; Caffeine; Convulsants; Electroencephalography; Ethanol; Geniculate Bodies; Glycolates; Histidine; Hydroxybutyrates; Hypnotics and Sedatives; Indoles; Lithium; Mescaline; Methamphetamine; Neurotransmitter Agents; Occipital Lobe; Phentolamine; Phenytoin; Pons; Probenecid; Rabbits; Tranquilizing Agents	1976
Mass spectrometry of medicines. Quantitative determination by direct probe inlet system mass chromatography. Biomedical mass spectrometry, 1978, Volume: 5, Issue:3 Topics: Aspirin; Barbital; Barbiturates; Caffeine; Mass Spectrometry; Pharmaceutical Preparations; Phenacetin; Phenobarbital; Phenytoin	1978
Nicotine self-administration in rats. NIDA research monograph, 1979, Issue:23 Topics: Amphetamine; Animals; Caffeine; Chlordiazepoxide; Chlorpromazine; Drug Interactions; Drug Tolerance; Ethanol; Humans; Male; Mecamylamine; Nicotine; Pentolinium Tartrate; Phenobarbital; Phenytoin; Rats; Reinforcement, Psychology; Self Administration; Substance-Related Disorders	1979
Use of saliva in therapeutic drug monitoring. Clinical chemistry, 1977, Volume: 23, Issue:2 PT. 1 Topics: Antipyrine; Caffeine; Ethosuximide; Gas Chromatography-Mass Spectrometry; Humans; Immunoenzyme Techniques; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Primidone; Saliva; Theophylline	1977
Chemical ionization mass spectrometry for rapid assay of drugs in serum. Journal of chromatography, 1976, Nov-03, Volume: 126 Topics: Anticonvulsants; Barbiturates; Caffeine; Carbamazepine; Electrochemistry; Mass Spectrometry; Nicotine; Phenytoin; Primidone; Temperature; Time Factors	1976
Clinical applications of gas chromatograph/mass spectrometer/computer systems. Clinical chemistry, 1975, Volume: 21, Issue:9 Topics: Autoanalysis; Caffeine; Chromatography, Gas; Computers; Diazepam; Evaluation Studies as Topic; Female; Humans; Imides; Indicators and Reagents; Mass Spectrometry; Methods; Milk, Human; Pentobarbital; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Pregnancy; Theobromine; Time Factors	1975
Urinary caffeine metabolites in man. Age-dependent changes and pattern in various clinical situations. European journal of clinical pharmacology, 1992, Volume: 43, Issue:2 Topics: Adolescent; Adult; Age Factors; Allopurinol; Caffeine; Child; Cimetidine; Drug Interactions; Female; Humans; Kidney Failure, Chronic; Liver Cirrhosis; Male; Phenytoin; Smoking; Theophylline	1992
Inhibition of alloxan-induced hyperglycaemia by compounds of similar molecular structure. Biochemical pharmacology, 1992, Dec-01, Volume: 44, Issue:11 Topics: Allantoin; Alloxan; Animals; Barbiturates; Blood Glucose; Caffeine; Ethosuximide; Hyperglycemia; Inositol; Male; Mice; Phenytoin; Structure-Activity Relationship; Theophylline; Uric Acid	1992
Interactions of fatty acids with the calcium release channel in malignant hyperthermia. Advances in experimental medicine and biology, 1991, Volume: 301 Topics: Animals; Caffeine; Calcium Channels; Fatty Acids; Halothane; Horses; Humans; Isoproterenol; Lipase; Malignant Hyperthermia; Muscle Proteins; Phenytoin; Ryanodine; Succinylcholine; Swine; Triglycerides	1991
Selective potentiation of subtetanic and tetanic contractions by the calcium-channel antagonist nifedipine in the rat diaphragm preparation. General pharmacology, 1991, Volume: 22, Issue:2 Topics: Animals; Caffeine; Calcium; Diaphragm; Electric Stimulation; Female; In Vitro Techniques; Male; Membranes; Muscle Contraction; Nifedipine; Phenytoin; Potassium; Quinine; Rats; Rats, Inbred Strains; Respiratory Muscles	1991
Determination of anticonvulsant drugs and methyl xanthine derivatives in serum by liquid chromatography with direct injection: column-switching method using a new internal-surface reversed-phase silica support as a precolumn. Journal of chromatography, 1990, Aug-03, Volume: 529, Issue:2 Topics: Anticonvulsants; Caffeine; Carbamazepine; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Phenobarbital; Phenytoin; Primidone; Silicon Dioxide; Spectrophotometry, Ultraviolet; Theobromine; Theophylline; Xanthines	1990
[Plasma determination of 7 common drugs by high performance liquid chromatography]. Annales de biologie clinique, 1989, Volume: 47, Issue:2 Topics: Anticonvulsants; Bronchodilator Agents; Caffeine; Carbamazepine; Chromatography, High Pressure Liquid; Ethosuximide; Phenobarbital; Phenytoin; Theophylline; Valproic Acid	1989
Effect of phenytoin, carbamazepine, and valproic acid on caffeine metabolism. European journal of clinical pharmacology, 1989, Volume: 36, Issue:4 Topics: Adolescent; Adult; Aged; Antipyrine; Caffeine; Carbamazepine; Cytochrome P-450 Enzyme System; Enzyme Induction; Epilepsy; Female; Half-Life; Humans; Hydrocortisone; Male; Middle Aged; Phenytoin; Valproic Acid	1989
Effects of dietary xenobiotics on the metabolism of copper, alpha-tocopherol and cholesterol in rats. Journal of nutritional science and vitaminology, 1987, Volume: 33, Issue:4 Topics: Animals; Body Weight; Butylated Hydroxyanisole; Caffeine; Ceruloplasmin; Chlorobutanol; Cholesterol; Copper; DDT; Diet; Flavones; Flavonoids; Kidney; Liver; Male; Pharmaceutical Preparations; Phenytoin; Polychlorinated Biphenyls; Rats; Rats, Inbred Strains; Vitamin E	1987
Robust regression in biological assay: application to the evaluation of alternative experimental techniques. Experientia, 1988, Oct-15, Volume: 44, Issue:10 Topics: Animal Testing Alternatives; Animals; Biological Assay; Brain; Caffeine; Cells, Cultured; Chick Embryo; Culture Techniques; Embryo, Mammalian; Phenytoin; Rats; Regression Analysis; Software; Statistics as Topic	1988
Inhibition and induction of drug biotransformation in vivo by 8-methoxypsoralen: studies of caffeine, phenytoin and hexobarbital metabolism in the rat. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:1 Topics: Animals; Biotransformation; Caffeine; Hexobarbital; Male; Methoxsalen; Phenytoin; Rats; Rats, Inbred Strains	1987
The effect of chronic oral ketoconazole on in vivo drug metabolism in the rat. Research communications in chemical pathology and pharmacology, 1986, Volume: 54, Issue:2 Topics: Administration, Oral; Animals; Caffeine; Ketoconazole; Liver; Male; Pharmaceutical Preparations; Phenytoin; Rats	1986
[Therapy of arrhythmias]. Wiener Zeitschrift fur innere Medizin und ihre Grenzgebiete, 1973, Volume: 54, Issue:8-9 Topics: Ajmaline; Arrhythmias, Cardiac; Atrial Fibrillation; Bradycardia; Caffeine; Cardiac Complexes, Premature; Digitalis Glycosides; Heart Block; Humans; Lidocaine; Metaproterenol; Phenytoin; Procainamide; Tachycardia; Ventricular Fibrillation; Verapamil	1973
[Studies on the effect of various substances on platelet function with several methods]. Die Medizinische Welt, 1973, Feb-02, Volume: 24, Issue:5 Topics: Amphetamine; Anti-Anxiety Agents; Blood Platelets; Caffeine; Chlorpromazine; Debrisoquin; Dibenzazepines; Flurazepam; Guanethidine; Humans; Oxazoles; Papaverine; Phenytoin; Platelet Aggregation; Pyridines; Theophylline	1973
A systematic study of variables affecting protein binding of thyroxine and triiodothyronine in serum. Scandinavian journal of clinical and laboratory investigation, 1974, Volume: 34, Issue:3 Topics: Anions; Barbiturates; Buffers; Caffeine; Depression, Chemical; Dialysis; Humans; Hydrogen-Ion Concentration; Iodine Radioisotopes; Methimazole; Osmolar Concentration; Phenytoin; Protein Binding; Salicylates; Temperature; Theophylline; Thyroxine; Thyroxine-Binding Proteins; Time Factors; Triiodothyronine; Ultrafiltration	1974
Prevention by antidepressant drugs of reserpine effect on pyridine nucleotide metabolism. Molecular pharmacology, 1966, Volume: 2, Issue:4 Topics: Aminopyrine; Amitriptyline; Amphetamine; Animals; Antidepressive Agents; Atropine; Benactyzine; Caffeine; Chlorpheniramine; Chlorpromazine; Female; Hexobarbital; Hydralazine; Hypothalamus; Imipramine; Iproniazid; Isoniazid; Liver; Meprobamate; Methacholine Compounds; Morphine; NAD; Niacinamide; Pargyline; Pentobarbital; Phenylbutazone; Phenytoin; Quinacrine; Rats; Reserpine; Tranylcypromine; Tripelennamine; Zoxazolamine	1966
The effects of caffeine on sodium transport, membrane potential, mechanical tension and ultrastructure in barnacle muscle fibres. The Journal of physiology, 1974, Volume: 242, Issue:1 Topics: Acetates; Animals; Biological Transport, Active; Caffeine; Calcium; Calcium Chloride; Chelating Agents; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Glycols; Hydrogen-Ion Concentration; In Vitro Techniques; Membrane Potentials; Microscopy, Electron; Muscle Contraction; Myofibrils; Ouabain; Phenytoin; Phosphoric Diester Hydrolases; Procaine; Sodium; Stimulation, Chemical; Thoracica	1974
Theophylline inhibition of nucleoside transport and its relation to cyclic AMP in skeletal muscle. Canadian journal of physiology and pharmacology, 1974, Volume: 52, Issue:6 Topics: Adenine; Adenosine; Animals; Biological Transport; Bucladesine; Caffeine; Carbon Radioisotopes; Chromatography, Paper; Cyclic AMP; Hypoxanthines; In Vitro Techniques; Inosine; Isoproterenol; Muscle Contraction; Muscles; Nucleosides; Phenytoin; Propranolol; Protein Binding; Purines; Rana pipiens; Ribose; Sorbitol; Theophylline; Tritium; Uridine	1974
[Treatment of partial epilepsies with a sultiamum containing combination]. Arzneimittel-Forschung, 1969, Volume: 19, Issue:12 Topics: Adolescent; Adult; Aggression; Anticonvulsants; Barbiturates; Caffeine; Child; Electroencephalography; Epilepsy; Euphoria; Feeding and Eating Disorders; Female; Gastrointestinal Diseases; Humans; Impulsive Behavior; Male; Paresthesia; Phenytoin; Thiazines; Vertigo	1969
Brain uptake of metabolites and drugs following carotid arterial injections. Transactions of the American Neurological Association, 1971, Volume: 96 Topics: Acetates; Amino Acids; Animals; Antipyrine; Ascorbic Acid; Aspirin; Barbiturates; Blood-Brain Barrier; Brain; Caffeine; Chloroquine; Cyanides; Ethanol; Imipramine; Lactates; Mescaline; Morphine; Neurotransmitter Agents; Nicotine; Penicillin G; Pharmaceutical Preparations; Phenytoin; Procaine; Pyruvates; Rats	1971
Effect on pseudoconditioning of drugs with known central nervous activity. Psychopharmacologia, 1974, Volume: 38, Issue:3 Topics: Amobarbital; Animals; Avoidance Learning; Behavior, Animal; Caffeine; Cannabis; Chlorpromazine; Conditioning, Psychological; Depression, Chemical; Diazepam; Dibenzylchlorethamine; Female; Meprobamate; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Rats; Stimulation, Chemical; Strychnine; Trimethadione	1974
[Drug permeation through synthetic lipid membranes. Permeability of lecithin-collodium membranes for drugs and metabolites]. Die Pharmazie, 1974, Volume: 29, Issue:9 Topics: Buffers; Caffeine; Diffusion; Hexobarbital; Hydrogen-Ion Concentration; Kinetics; Membranes, Artificial; Models, Chemical; Papaverine; Phenobarbital; Phenytoin; Phosphatidylcholines; Quinine; Salicylates; Solutions; Time Factors	1974
Use of stable isotopes in measuring low concentrations of drugs and drug metabolites by GC-MS-COM procedures. Clinical chemistry, 1973, Volume: 19, Issue:8 Topics: Amniotic Fluid; Barbiturates; Caffeine; Carbon Isotopes; Child; Chromatography, Gas; Colostrum; Computers; Fatty Acids; Female; Humans; Hypnotics and Sedatives; Infant, Newborn; Male; Mass Spectrometry; Maternal-Fetal Exchange; Methods; Microchemistry; Milk, Human; Phenobarbital; Phenytoin; Pregnancy	1973
[Detection of sedative effect by electronystagmography]. Arzneimittel-Forschung, 1969, Volume: 19, Issue:9 Topics: Amphetamine; Antihypertensive Agents; Caffeine; Chlorpromazine; Dibenzazepines; Electric Stimulation; Humans; Hypnotics and Sedatives; Imidazoles; Methods; Pentobarbital; Phenmetrazine; Phenothiazines; Phenytoin; Promethazine; Thiethylperazine; Vestibular Function Tests	1969
Physiological and drug-induced changes in the glycogen content of mouse brain. British journal of pharmacology, 1970, Volume: 39, Issue:1 Topics: Amphetamine; Animals; Bemegride; Body Temperature; Brain Chemistry; Caffeine; Catecholamines; Circadian Rhythm; Diphenhydramine; Glucose; Glycogen; Hyperglycemia; Insulin; Male; Mice; Motor Activity; Nialamide; Phenytoin; Propranolol; Seizures; Temperature	1970
Sphenopalatine gangionectomy for cluster headache. Archives of otolaryngology (Chicago, Ill. : 1960), 1970, Volume: 92, Issue:5 Topics: Adult; Analgesics; Caffeine; Carbamazepine; Cortisone; Diazepam; Ergotamine; Female; Ganglia, Autonomic; Headache; Humans; Isoproterenol; Male; Methods; Methysergide; Middle Aged; Neuralgia; Palate; Phenytoin; Progesterone; Prognosis; Sphenoid Bone	1970
Influence of several drugs on the in vivo and in vitro activity of mammalian hepatic azo-reductase. Canadian journal of biochemistry, 1968, Volume: 46, Issue:4 Topics: Animals; Caffeine; Guanethidine; Guinea Pigs; In Vitro Techniques; Iproniazid; Isoniazid; Liver; Nitrofurantoin; Oxidoreductases; Pentylenetetrazole; Phenobarbital; Phenylbutazone; Phenytoin; Rabbits; Rats; Sulfinpyrazone; Sulfonic Acids; Trimethadione	1968
Paroxysmal dystonic choreoathetosis. A family study and review of the literature. Neurology, 1968, Volume: 18, Issue:5 Topics: Adult; Aged; Amobarbital; Athetosis; Atropine; Benzoates; Caffeine; Child, Preschool; Chorea; Coffee; Consciousness; Electroencephalography; Fatigue; Female; Functional Laterality; Humans; Male; Middle Aged; Motion Pictures; Muscles; Muscular Diseases; Neostigmine; Pedigree; Phenobarbital; Phenytoin; Phytotherapy; Stress, Physiological; Suggestion	1968
Interactions between pharmaceutical compounds by thermal methods. Journal of pharmaceutical sciences, 1969, Volume: 58, Issue:3 Topics: Acetaminophen; Aspirin; Atropine; Bile Acids and Salts; Caffeine; Drug Compounding; Drug Incompatibility; Drug Stability; Methods; Phenacetin; Phenobarbital; Phenytoin; Quinine; Temperature; Theophylline; Thermodynamics; Time Factors; Vitamin K	1969
[New viewpoints on migraine therapy]. Medizinische Monatsschrift, 1966, Volume: 20, Issue:1 Topics: Caffeine; Female; Humans; Male; Migraine Disorders; Phenytoin	1966
Interaction of anticonvulsant drugs with adenosine receptors in the central nervous system. Epilepsia, 1984, Volume: 25, Issue:4 Topics: Adenosine; Animals; Anticonvulsants; Brain; Caffeine; Carbamazepine; Cerebellum; Cerebral Cortex; Cyclic AMP; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Purinergic; Theophylline	1984
Programming of rat hepatic arylhydrocarbon hydroxylase activity during late neonatal period. Proceedings of the Western Pharmacology Society, 1982, Volume: 25 Topics: Animals; Animals, Newborn; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrenes; Caffeine; DNA; Female; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains	1982
The toxicology of chemical interactions during pregnancy in the mouse: caffeine and phenytoin. Toxicology, 1984, Feb-14, Volume: 30, Issue:1 Topics: Animals; Caffeine; Drug Interactions; Female; Fetal Death; Fetal Resorption; Mice; Mice, Inbred ICR; Phenytoin; Pregnancy; Teratogens	1984
The interaction of chemicals during pregnancy: an update. Biological research in pregnancy and perinatology, 1983, Volume: 4, Issue:1 Topics: Abnormalities, Drug-Induced; Animals; Bromodeoxyuridine; Caffeine; Drug Interactions; Female; Fetus; Humans; Hydroxyurea; Mice; Phenytoin; Pregnancy; Prenatal Exposure Delayed Effects; Rats	1983
Effects of chlorpromazine and other drugs acting on the central nervous system on human sperm motility. European journal of clinical pharmacology, 1982, Volume: 22, Issue:5 Topics: Caffeine; Central Nervous System; Chlorpromazine; Diazepam; Humans; In Vitro Techniques; Male; Phenobarbital; Phenytoin; Sperm Motility	1982
Effect of phenytoin on skeletal muscle from quarter horses with hyperkalaemic periodic paralysis. Research in veterinary science, 1995, Volume: 58, Issue:3 Topics: Animals; Caffeine; Calcium; Halothane; Horse Diseases; Horses; Hyperkalemia; Muscle Contraction; Muscle, Skeletal; Paralysis; Phenytoin; Potassium	1995
Changes in the metabolism of three model substrates catalysed by different P450 isozymes when administered as a cocktail to the carbon tetrachloride-intoxicated rat. Xenobiotica; the fate of foreign compounds in biological systems, 1995, Volume: 25, Issue:10 Topics: Animals; Biotransformation; Caffeine; Carbon Tetrachloride Poisoning; Cytochrome P-450 Enzyme System; Hydantoins; Injections, Intravenous; Isoenzymes; Lidocaine; Male; Phenytoin; Rats; Rats, Sprague-Dawley; Theophylline	1995
Kinetics of drug metabolism in rat liver slices. II. Comparison of clearance by liver slices and freshly isolated hepatocytes. Drug metabolism and disposition: the biological fate of chemicals, 1996, Volume: 24, Issue:6 Topics: Animals; Anticonvulsants; Caffeine; Central Nervous System Stimulants; Diazepam; In Vitro Techniques; Kinetics; Liver; Male; Phenytoin; Rats; Rats, Sprague-Dawley	1996
Kinetics of drug metabolism in rat liver slices. III. Relationship between metabolic clearance and slice uptake rate. Drug metabolism and disposition: the biological fate of chemicals, 1997, Volume: 25, Issue:4 Topics: Animals; Caffeine; Diazepam; In Vitro Techniques; Liver; Male; Ondansetron; Pharmacokinetics; Phenytoin; Rats; Rats, Sprague-Dawley; Tolbutamide	1997
A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro. Xenobiotica; the fate of foreign compounds in biological systems, 1999, Volume: 29, Issue:3 Topics: Alkaline Phosphatase; beta-Naphthoflavone; Caffeine; Carbamazepine; Carcinoma, Hepatocellular; Clofibrate; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Gene Expression Regulation; Genes, Reporter; Glucocorticoids; Hormone Antagonists; Humans; Isoniazid; Mifepristone; Mixed Function Oxygenases; Phenobarbital; Phenylbutazone; Phenytoin; Receptors, Glucocorticoid; Recombinant Proteins; Rifampin; Tumor Cells, Cultured; Xenobiotics	1999
[Application of statistical simulation spectrophotometry to the determination of four medicaments in feibaosanxiao tablets]. Yao xue xue bao = Acta pharmaceutica Sinica, 1998, Volume: 33, Issue:9 Topics: Acetaminophen; Caffeine; Drug Combinations; Monte Carlo Method; Phenytoin; Spectrophotometry; Tablets; Theophylline	1998
[On the therapy of idiopathic and symptomatic headache and facial pains]. Medizinische Monatsschrift, 1963, Volume: 17 Topics: Caffeine; Facial Neuralgia; Facial Pain; Headache; Humans; Phenytoin; Trigeminal Neuralgia	1963
[TREATMENT OF DYSRHYTHMIC MIGRAINE AND OTHER FORMS OF HEADACHE WITH A NEW COMBINATION PREPARATION (SANREDO)]. Schweizerische medizinische Wochenschrift, 1963, Sep-14, Volume: 93 Topics: Caffeine; Ergotamine; Headache; Humans; Migraine Disorders; Phenytoin	1963
[GENESIS, CLASSIFICATION AND THERAPY OF LOSS OF CONSCIOUSNESS]. Monatsschrift fur Kinderheilkunde, 1963, Volume: 111 Topics: Caffeine; Child; Classification; Electroencephalography; Epilepsy; Epilepsy, Absence; Humans; Oxyphenbutazone; Phenobarbital; Phenytoin; Physiology; Pyrrolidinones; Unconsciousness	1963
ISONIAZID INTOXICATIONS. New York state journal of medicine, 1964, Mar-01, Volume: 64 Topics: Amobarbital; Anti-Bacterial Agents; Caffeine; Child; Ions; Isoniazid; New York; Phenylephrine; Phenytoin; Protein Synthesis Inhibitors; Pyridoxine; Sodium; Sodium, Dietary; Tetracycline; Toxicology	1964
[ON THE INTERVAL TREATMENT OF MIGRAINE]. Therapeutische Umschau. Revue therapeutique, 1964, Volume: 21 Topics: Caffeine; Cardiovascular Agents; Ergot Alkaloids; Migraine Disorders; Phenytoin	1964
[ON A PROLONGED DRUG THERAPY IN REFRACTORY MIGRAINE]. Therapeutische Umschau. Revue therapeutique, 1964, Volume: 21 Topics: Caffeine; Drug Therapy; Ergotamine; Humans; Migraine Disorders; Phenytoin	1964
[TREATMENT OF TRIGEMINAL NEURALGIA WITH CENTROMID]. Die Medizinische Welt, 1965, Feb-27, Volume: 82 Topics: Caffeine; Drug Therapy; Geriatrics; Herpes Zoster; Humans; Phenytoin; Trigeminal Neuralgia	1965
Simultaneous determination of phenytoin, barbital and caffeine in pharmaceuticals by absorption (zero-order) UV spectra and first-order derivative spectra--multivariate calibration methods. Journal of pharmaceutical and biomedical analysis, 2005, Jul-01, Volume: 38, Issue:3 Topics: Barbital; Caffeine; Calibration; Least-Squares Analysis; Molecular Structure; Multivariate Analysis; Pharmaceutical Preparations; Phenytoin; Regression Analysis; Reproducibility of Results; Spectrophotometry, Ultraviolet; Technology, Pharmaceutical	2005
Integration of in vitro neurotoxicity data with biokinetic modelling for the estimation of in vivo neurotoxicity. Human & experimental toxicology, 2007, Volume: 26, Issue:4 Topics: Acrylamide; Animals; Anticonvulsants; Brain Neoplasms; Caffeine; Calcium Channels; Central Nervous System Stimulants; Diazepam; Endpoint Determination; Humans; Hypnotics and Sedatives; Kinetics; Lethal Dose 50; Models, Statistical; Nerve Tissue Proteins; Neuroblastoma; Neurotoxicity Syndromes; Pesticides; Phenytoin; Rats; Xenobiotics	2007
A tandem mass spectrometry assay for the simultaneous determination of acetaminophen, caffeine, phenytoin, ranitidine, and theophylline in small volume pediatric plasma specimens. Clinica chimica acta; international journal of clinical chemistry, 2008, Volume: 398, Issue:1-2 Topics: Acetaminophen; Analgesics; Anticonvulsants; Bronchodilator Agents; Caffeine; Calibration; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Histamine H2 Antagonists; Humans; Infant, Newborn; Phenytoin; Quality Control; Ranitidine; Reference Standards; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Theophylline	2008
Application of a systems approach to the bottom-up assessment of pharmacokinetics in obese patients: expected variations in clearance. Clinical pharmacokinetics, 2011, Dec-01, Volume: 50, Issue:12 Topics: Adolescent; Adult; Aged; Benzodiazepines; Body Weights and Measures; Caffeine; Chlorzoxazone; Computer Simulation; Cyclosporine; Female; Gastrointestinal Tract; Humans; Kidney; Liver; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Obesity; Obesity, Morbid; Pharmacokinetics; Phenytoin; Regional Blood Flow; Theophylline; Young Adult	2011
Pharmacological classification of herbal extracts by means of comparison to spectral EEG signatures induced by synthetic drugs in the freely moving rat. Journal of ethnopharmacology, 2013, Sep-16, Volume: 149, Issue:2 Topics: Animals; Brain; Caffeine; Electroencephalography; Magnoliopsida; Methylphenidate; Paroxetine; Phenytoin; Plant Extracts; Rats; Tramadol	2013
Caffeine intoxication: Behavioral and electrocorticographic patterns in Wistar rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2022, Volume: 170 Topics: Animals; Anticonvulsants; Caffeine; Diazepam; Pentylenetetrazole; Phenobarbital; Phenytoin; Rats; Rats, Wistar; Seizures	2022
Urgent first-step screening method for ketamine, phenobarbital, zopiclone, zolpidem, phenytoin and thiopental in adulterated soft drink. Pakistan journal of pharmaceutical sciences, 2023, Volume: 36, Issue:5 Topics: Caffeine; Carbonated Beverages; Female; Humans; Ketamine; Phenobarbital; Phenytoin; Reproducibility of Results; Thiopental; Zolpidem	2023