phenytoin and bilirubin

phenytoin has been researched along with bilirubin in 40 studies

Research

Studies (40)

Timeframe	Studies, this research(%)	All Research%
pre-1990	35 (87.50)	18.7374
1990's	2 (5.00)	18.2507
2000's	2 (5.00)	29.6817
2010's	1 (2.50)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Gilbert, JC; Jeffers, TA; Petrie, JC; Scott, AK	1
Hintze, KL; Levy, G; Slattery, JT; Wiegand, UW	2
Gretch, M; Jusko, WJ	1
Bennett, WM; Olsen, GD; Porter, GA	1
Berk, PD; Blaschke, TF; Martin, JF; Plotz, PH; Scharschmidt, BF	1
Blaschke, TF; Meffin, PJ; Melmon, KL; Rowland, M	1
Moult, PJ; Sherlock, S	1
Petruch, F; Schüppel, RV	1
Jacobsen, NO; Mosekilde, L; Myhre-Jensen, O; Pedersen, E; Wildenhoff, KE	1
Bock, KW; Bock-Hennig, BS	1
Buckels, JA; Elias, E; Gunson, BK; Hillis, A; Jain, AB; McDowell, B; McMaster, P	1
Rane, A; Sjöqvist, F	1
Giacoia, GP; Krasner, J; Yaffe, SJ	1
Andreasen, PB; Lyngbye, J; Trolle, E	1
Bochner, F; Eadie, MJ; Hooper, WD; Tyrer, JH	1
Berk, PD; Blaschke, TF; Guyther, JR; Scharschmidt, BF; Vergalla, JM; Waggoner, JG	1
Petruch, F; Schüppel, RV; Steinhilber, G	1
Ito, S	1
Mirkin, BL; Sharp, HL	1
Krasner, J	1
Jalling, B; Lunde, PK; Rane, A; Sjöqvist, F; Yaffe, SJ	1
Agurell, S; Boréus, LO; Ehrnebo, M; Jalling, B	1
Lunde, KM	1
Coburn, RF	1
Black, M	1
Benedetti, MS; Dostert, P	1
Davis, SJ; Marks, V	1
Hawksworth, GM; Khir, AS; Petrie, JC; Scott, AK; Steele, WH	1
Chiba, K; Ishizaki, T; Tabuchi, T; Wagatsuma, T; Yokochi, K	1
Coenegracht, JM; Oei, TL; van Breda Vriesman, PJ	1
Perucca, E	1
Eadie, MJ; Heazelwood, R; Patterson, M; Smithurst, B	1
Hamar, C; Levy, G	1
Burchell, B; Ebner, T; Sutherland, L	1
Crossey, MJ; Dasgupta, A	1
MURPHY, BE; PATTEE, CJ	1
Dasgupta, A; Datta, P; Scurlock, D	1
Aykac, B; Koner, O; Mercan, A; Türe, H; Türe, U	1
Berg, MJ; Braun, KP; Koudijs, SM; Malingré, MM; ter Heine, R; van der Westerlaken, MM; van Maarseveen, EM	1

Reviews

5 review(s) available for phenytoin and bilirubin

Article	Year
Plasma and tissue protein binding of drugs in pharmacokinetics. Drug metabolism reviews, 1976, Volume: 5, Issue:1 Topics: Adrenal Cortex Hormones; Age Factors; Aging; Albumins; Animals; Anti-Bacterial Agents; Antibodies; Anticoagulants; Bilirubin; Binding Sites; Blood Proteins; Disease; Drug Interactions; Female; Fetus; Guinea Pigs; Haplorhini; Humans; Kinetics; Liver Cirrhosis; Models, Biological; Neoplasms; Organ Specificity; Pharmaceutical Preparations; Phenytoin; Pregnancy; Propranolol; Protein Binding; Proteins; Rabbits; Receptors, Drug; Species Specificity; Structure-Activity Relationship	1976
Drug metabolism in the human fetus and newborn infant. Pediatric clinics of North America, 1972, Volume: 19, Issue:1 Topics: Aminobenzoates; Anti-Bacterial Agents; Bilirubin; Diazepam; Electron Transport; Endoplasmic Reticulum; Ethers, Cyclic; Female; Fetus; Half-Life; Humans; Infant, Newborn; Liver; Maternal-Fetal Exchange; Microsomes, Liver; NADP; Nortriptyline; Pharmaceutical Preparations; Phenytoin; Pregnancy; Sulfobromophthalein; Testosterone	1972
[Recent data on thyroxine-binding protein]. Saishin igaku. Modern medicine, 1967, Volume: 22, Issue:7 Topics: Androgens; Animals; Anticoagulants; Barbiturates; Bilirubin; Carbon Dioxide; Chemical Phenomena; Chemistry, Physical; Diuretics; Estrogens; Glucocorticoids; Humans; Novobiocin; Penicillins; Phenylbutazone; Phenytoin; Salicylates; Thyroid Diseases; Thyroxine; Thyroxine-Binding Proteins; Tolbutamide	1967
[Biochemical mechanisms of the hepatotoxicity of psychotropic drugs]. L'Encephale, 1984, Volume: 10, Issue:5 Topics: Acute Disease; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Bilirubin; Butyrophenones; Chemical and Drug Induced Liver Injury; Chlorpromazine; Chronic Disease; Drug Hypersensitivity; Humans; Liver; Monoamine Oxidase Inhibitors; Phenytoin; Psychotropic Drugs; Thioxanthenes	1984
Plasma protein binding of phenytoin in health and disease: relevance to therapeutic drug monitoring. Therapeutic drug monitoring, 1980, Volume: 2, Issue:4 Topics: Aging; Bilirubin; Blood Proteins; Burns; Disease; Drug Interactions; Fatty Acids, Nonesterified; Humans; Kidney Diseases; Lipids; Liver Diseases; Phenytoin; Postoperative Complications; Protein Binding; Serum Albumin	1980

Trials

1 trial(s) available for phenytoin and bilirubin

Article	Year
Effect of phenobarbital on hyperbilirubinemia, bile acid metabolism, and microsomal enzyme activity in chronic intrahepatic cholestasis of childhood. The Journal of pediatrics, 1972, Volume: 81, Issue:1 Topics: Bile; Bile Acids and Salts; Bilirubin; Biopsy; Child; Child, Preschool; Cholestasis; Chronic Disease; Humans; Liver; Microsomes, Liver; Phenobarbital; Phenytoin; Rose Bengal	1972

Other Studies

34 other study(ies) available for phenytoin and bilirubin

Article	Year
Serum bilirubin and hepatic enzyme induction. British medical journal, 1979, Aug-04, Volume: 2, Issue:6185 Topics: Adolescent; Adult; Aged; Bilirubin; Enzyme Induction; Humans; Liver; Middle Aged; Phenobarbital; Phenytoin; Time Factors	1979
Differences in the protein binding of several drugs and bilirubin in serum and heparinized plasma of rats. Life sciences, 1979, Jul-30, Volume: 25, Issue:5 Topics: Animals; Bilirubin; Heparin; Male; Phenytoin; Protein Binding; Rats; Salicylates; Warfarin	1979
Morphine and phenytoin binding to plasma proteins in renal and hepatic failure. Clinical pharmacology and therapeutics, 1975, Volume: 17, Issue:6 Topics: Bilirubin; Blood Proteins; Creatinine; Humans; Jaundice; Kidney Failure, Chronic; Kidney Transplantation; Liver Diseases; Morphine; Phenytoin; Protein Binding; Renal Dialysis; Serum Albumin; Uremia	1975
Unconjugated hyperbilirubinemia. Physiologic evaluation and experimental approaches to therapy. Annals of internal medicine, 1975, Volume: 82, Issue:4 Topics: Adult; Albumins; Animals; Bilirubin; Crigler-Najjar Syndrome; Ethosuximide; Female; Gilbert Disease; Glutethimide; Hemolysis; Humans; Hyperbilirubinemia; Liver; Phenobarbital; Phenytoin; Phototherapy; Plasmapheresis; Rats; Seizures	1975
Influence of acute viral hepatitis on phenytoin kinetics and protein binding. Clinical pharmacology and therapeutics, 1975, Volume: 17, Issue:6 Topics: Bilirubin; Blood Proteins; Chromatography, Gas; Half-Life; Hepatitis A; Humans; Kinetics; Liver Function Tests; Phenytoin; Protein Binding; Serum Albumin	1975
Halothane-related hepatitis. A clinical study of twenty-six cases. The Quarterly journal of medicine, 1975, Volume: 44, Issue:173 Topics: Adult; Aged; Anesthesia, General; Bilirubin; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Female; Glucose; Halothane; Humans; Jaundice; Male; Middle Aged; Neomycin; Penicillins; Phenothiazines; Phenytoin; Postoperative Complications; Sulfonamides; Tetracycline; Trimethoprim	1975
[Effects of anticonvulsive treatment on drug elimination in man. Induction of liver hydroxylating enzyme system by diphenylhydantoin and carbamazepine]. Bibliotheca psychiatrica, 1975, Issue:151 Topics: Adult; Antipyrine; Bilirubin; Carbamazepine; Creatinine; Epilepsy; Female; Half-Life; Humans; Hydroxylation; Liver; Male; Middle Aged; Phenytoin; Time Factors; Trigeminal Neuralgia	1975
Liver biopsies in epileptics during anticonvulsant therapy. Acta medica Scandinavica, 1976, Volume: 199, Issue:5 Topics: Adolescent; Adult; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubin; Epilepsy; Female; Humans; Liver; Male; Middle Aged; Phenytoin; Prothrombin Time; Serum Albumin; Time Factors	1976
Differential induction of human liver UDP-glucuronosyltransferase activities by phenobarbital-type inducers. Biochemical pharmacology, 1987, Dec-01, Volume: 36, Issue:23 Topics: Acetaminophen; Adolescent; Adult; Benzopyrenes; Bilirubin; Carcinoma, Hepatocellular; Enzyme Induction; Female; Glucuronosyltransferase; Humans; Hydroquinones; Hymecromone; Isoenzymes; Liver Neoplasms; Male; Methylcholanthrene; Microsomes, Liver; Middle Aged; Naphthols; Pentobarbital; Phenytoin; Tumor Cells, Cultured	1987
Is elimination of cyclosporine in bile dependent on liver graft function and biliary drainage? Transplantation proceedings, 1988, Volume: 20, Issue:2 Suppl 2 Topics: Alanine Transaminase; Alkaline Phosphatase; Bile; Bilirubin; Cyclosporins; Humans; Liver; Liver Transplantation; Metabolic Clearance Rate; Phenytoin	1988
Drug-protein binding in the newborn infant. Annals of the New York Academy of Sciences, 1973, Nov-26, Volume: 226 Topics: Adult; Animals; Bilirubin; Blood; Blood Proteins; Cattle; Dialysis; Dimethyl Sulfoxide; Fluorescence; Humans; Infant, Newborn; Kinetics; Nafcillin; Pharmaceutical Preparations; Phenytoin; Protein Binding; Salicylates; Serum Albumin, Bovine; Umbilical Cord	1973
Abnormalities in liver function tests during long-term diphenylhydantoin therapy in epileptic out-patients. Acta medica Scandinavica, 1973, Volume: 194, Issue:4 Topics: Adolescent; Adult; Aged; Alanine Transaminase; Alkaline Phosphatase; Bilirubin; Calcium; Epilepsy; Female; Humans; Liver Function Tests; Male; Middle Aged; Phenytoin; Phosphates; Prothrombin Time; Serum Albumin	1973
Plasma protein binding of diphenylhydantoin. Effects of sex hormones, renal and hepatic disease. Clinical pharmacology and therapeutics, 1974, Volume: 15, Issue:3 Topics: Adult; Age Factors; Aged; Bilirubin; Blood Proteins; Contraceptives, Oral; Female; Gonadal Steroid Hormones; Humans; Kidney Diseases; Liver Diseases; Male; Middle Aged; Phenytoin; Pregnancy; Protein Binding; Serum Albumin; Ultrafiltration	1974
Crigler-Najjar syndrome: an unusual course with development of neurologic damage at age eighteen. Pediatric research, 1974, Volume: 8, Issue:5 Topics: Adolescent; Alkaline Phosphatase; Bilirubin; Brain Damage, Chronic; Brain Diseases; Carbon Monoxide; Erythrocyte Aging; Female; Glucuronates; Glutethimide; Humans; Hyperbilirubinemia, Hereditary; Indocyanine Green; Kanamycin; Liver Function Tests; Phenobarbital; Phenytoin; Phototherapy; Plasmapheresis; Protein Binding; Radioisotopes; Renal Dialysis; Salicylamides; Sulfobromophthalein; Syndrome; Transaminases	1974
Effect of diphenylhydantoin on hepatic drug hydroxylation. European journal of clinical pharmacology, 1974, Jul-26, Volume: 7, Issue:4 Topics: Adult; Antipyrine; Bilirubin; Colorimetry; Creatinine; Epilepsy; Half-Life; Humans; Hydroxylation; Jaundice; Liver; Male; Middle Aged; Pharmaceutical Preparations; Phenelzine; Phenytoin	1974
Drug-protein interaction. Pediatric clinics of North America, 1972, Volume: 19, Issue:1 Topics: Adult; Anti-Bacterial Agents; Bilirubin; Blood Protein Electrophoresis; Blood Proteins; Chromatography, Gel; Dialysis; Humans; Infant; Pharmaceutical Preparations; Pharmacology; Phenytoin; Protein Binding; Serum Albumin; Spectrophotometry; Ultracentrifugation	1972
Plasma protein binding of diphenylhydantoin in normal and hyperbilirubinemic infants. The Journal of pediatrics, 1971, Volume: 78, Issue:5 Topics: Bilirubin; Binding Sites; Blood Proteins; Carbon Isotopes; Desipramine; Female; Filtration; Humans; Hyperbilirubinemia; Infant, Newborn; Infant, Newborn, Diseases; Phenytoin; Pregnancy; Protein Binding; Serum Albumin; Tritium	1971
Age differences in drug binding by plasma proteins: studies on human foetuses, neonates and adults. European journal of clinical pharmacology, 1971, Volume: 3, Issue:4 Topics: Adult; Age Factors; Aging; Ampicillin; Azides; Bilirubin; Blood Proteins; Dialysis; Female; Fetus; Freezing; Gestational Age; Humans; Hydrogen-Ion Concentration; Hyperbilirubinemia; Infant, Newborn; Maternal-Fetal Exchange; Penicillin G; Phenobarbital; Phenytoin; Pregnancy; Protein Binding; Sulfur Isotopes	1971
Plasma protein binding of diphenylhydantoin in man. Acta pharmacologica et toxicologica, 1971, Volume: 29 Suppl 3 Topics: Adult; Aspirin; Bilirubin; Blood Proteins; Carbon Isotopes; Epilepsy; Female; Humans; Hydrogen-Ion Concentration; Hyperbilirubinemia; Infant, Newborn; Male; Phenylbutazone; Phenytoin; Protein Binding; Sulfisoxazole; Uremia	1971
Enhancement by phenobarbital and diphenylhydantoin of carbon monoxide production in normal man. The New England journal of medicine, 1970, Sep-03, Volume: 283, Issue:10 Topics: Adult; Bilirubin; Carbon Monoxide; Heme; Humans; Liver; Male; Phenobarbital; Phenytoin	1970
Drugs and the liver. Transactions of the Medical Society of London, 1970, Volume: 86 Topics: Bilirubin; Cushing Syndrome; DDT; Enzyme Induction; Ethanol; Female; Humans; Hyperbilirubinemia; Infant, Newborn; Jaundice, Neonatal; Liver; Male; Phenobarbital; Phenytoin; Porphyrins; Pregnancy; Transferases; Warfarin	1970
A critical evaluation of a new fluorescence immunoassay system for the measurement of serum phenytoin concentrations. Annals of clinical biochemistry, 1983, Volume: 20 (Pt 5) Topics: Bilirubin; Evaluation Studies as Topic; Fluorescent Antibody Technique; Hemoglobins; Humans; Lipids; Phenytoin	1983
Oxazepam pharmacokinetics in patients with epilepsy treated long-term with phenytoin alone or in combination with phenobarbitone. British journal of clinical pharmacology, 1983, Volume: 16, Issue:4 Topics: Adult; Bilirubin; Dialysis; Drug Interactions; Epilepsy; Female; Humans; Kinetics; Male; Middle Aged; Oxazepam; Phenobarbital; Phenytoin; Protein Binding	1983
Placental transfer of anticonvulsants (phenobarbital, phenytoin, valproic acid) and the elimination from neonates. Pediatric pharmacology (New York, N.Y.), 1981, Volume: 1, Issue:4 Topics: Anticonvulsants; Bilirubin; Female; Fetal Blood; Half-Life; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange; Phenobarbital; Phenytoin; Pregnancy; Valproic Acid	1981
The influence of bilirubin, alcohol and certain drugs on the kinetics of 99mTc-Diethyl IDA (EHIDA) in humans. European journal of nuclear medicine, 1983, Volume: 8, Issue:4 Topics: Alcoholism; Bilirubin; Epilepsy; Ethanol; Humans; Imino Acids; Jaundice; Kinetics; Phenobarbital; Phenytoin; Technetium; Technetium Tc 99m Diethyl-iminodiacetic Acid	1983
Plasma protein binding of phenytoin in the aged: in vivo studies. British journal of clinical pharmacology, 1982, Volume: 13, Issue:3 Topics: Aged; Aging; Bilirubin; Blood Proteins; Female; Humans; Male; Middle Aged; Phenytoin; Protein Binding	1982
Protein binding of several drugs in serum and plasma of healthy subjects. Clinical pharmacology and therapeutics, 1980, Volume: 27, Issue:3 Topics: Adult; Bilirubin; Female; Heparin; Humans; Isoelectric Point; Male; Phenytoin; Plasticizers; Propranolol; Protein Binding; Salicylates; Warfarin	1980
Serum protein binding of drugs and bilirubin in newborn infants and their mothers. Clinical pharmacology and therapeutics, 1980, Volume: 28, Issue:1 Topics: Bilirubin; Blood Proteins; Diazepam; Female; Fetal Blood; Humans; Individuality; Infant, Newborn; Oxytocin; Pharmaceutical Preparations; Phenytoin; Pregnancy; Protein Binding; Salicylates; Serum Albumin	1980
The expression of UDP-glucuronosyltransferases of the UGT1 family in human liver and kidney and in response to drugs. Biochemical pharmacology, 1993, Jan-26, Volume: 45, Issue:2 Topics: Aged; Bilirubin; Female; Gene Expression; Glucuronates; Glucuronosyltransferase; Humans; Isoenzymes; Kidney; Liver; Male; Microsomes, Liver; Middle Aged; Phenobarbital; Phenytoin; RNA, Messenger; Substrate Specificity	1993
Elevated free fatty acid concentrations in lipemic sera reduce protein binding of valproic acid significantly more than phenytoin. The American journal of the medical sciences, 1997, Volume: 313, Issue:2 Topics: Bilirubin; Blood Proteins; Charcoal; Creatinine; Fatty Acids, Nonesterified; Humans; Hyperlipidemias; Phenytoin; Protein Binding; Triglycerides; Urea; Valproic Acid	1997
DETERMINATION OF THYROXINE UTILIZING THE PROPERTY OF PROTEIN-BINDING. The Journal of clinical endocrinology and metabolism, 1964, Volume: 24 Topics: Aspirin; Bilirubin; Blood Chemical Analysis; Blood Proteins; Cholesterol; Glucose; Heparin; Hyperthyroidism; Hypothyroidism; Iodides; Iodine; Iodine Isotopes; Mercury; Oxalates; Phenytoin; Potassium; Research; Thyroid Function Tests; Thyroid Hormones; Thyroxine; Triiodothyronine	1964
Analytic performance evaluation of a new turbidimetric immunoassay for phenytoin on the ADVIA 1650 analyzer: effect of phenytoin metabolite and analogue. Therapeutic drug monitoring, 2005, Volume: 27, Issue:3 Topics: Bilirubin; Cross Reactions; Fluorescence Polarization Immunoassay; Hemolysis; Humans; Nephelometry and Turbidimetry; Oxaprozin; Phenytoin; Propionates	2005
The effects of propofol infusion on hepatic and pancreatic function and acid-base status in children undergoing craniotomy and receiving phenytoin. Anesthesia and analgesia, 2009, Volume: 109, Issue:2 Topics: Acid-Base Equilibrium; Analgesics, Opioid; Anesthetics, Intravenous; Anticonvulsants; Bilirubin; Blood Gas Analysis; Blood Transfusion; Child; Child, Preschool; Craniotomy; Female; Humans; Injections, Intravenous; Kidney Function Tests; Liver; Liver Function Tests; Male; Morphine; Phenytoin; Propofol; Supratentorial Neoplasms; Triglycerides	2009
The quantitative effect of serum albumin, serum urea, and valproic acid on unbound phenytoin concentrations in children. Journal of child neurology, 2014, Volume: 29, Issue:6 Topics: Adolescent; Anticonvulsants; Bilirubin; Carbamazepine; Child; Child, Preschool; Databases, Factual; Female; Humans; Infant; Infant, Newborn; Male; Netherlands; Nonlinear Dynamics; Phenytoin; Protein Binding; Retrospective Studies; Serum Albumin; Urea; Valproic Acid	2014