phenytoin and antipyrine

phenytoin has been researched along with antipyrine in 89 studies

Research

Studies (89)

Timeframe	Studies, this research(%)	All Research%
pre-1990	63 (70.79)	18.7374
1990's	9 (10.11)	18.2507
2000's	11 (12.36)	29.6817
2010's	6 (6.74)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Caron, G; Ermondi, G	1
Jolivette, LJ; Ward, KW	1
Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Duncton, MA; Emerling, DE; Kelly, MG; Nguyen, MT; Vincent, F	1
Campillo, NE; Guerra, A; Páez, JA	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Akamatsu, M	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G	1
Bending, MR; Dollery, CT; Kahn, GC; Mucklow, JC	1
Breckenridge, AM; Ohnhaus, EE; Park, BK	1
Brown, L; Horning, MG; Kellaway, P; Lertratanangkoon, K; Nowlin, J; Zion, TE	1
Bender, AD; Richey, DP	1
Byrne, E; Frewin, DB; Hallpike, JF; Harman, AW	1
Kampmann, JP; Lumholtz, BI; Mølholm Hansen, J; Siersbaek-Nielsen, K; Skovsted, L	1
Belpaire, FM; Bogaert, MG; van Peer, AP	3
Belpaire, F; Bogaert, M; Van Peer, A	1
Inaba, T; Kalow, W	1
Azarnoff, DL; Gugler, R	1
Gibaldi, M	1
Bill, P; Buchanan, N; Eyberg, C; Moodley, G	1
Meredith, PA; Ullah, M; Whitling, B	1
Reidenberg, MM	1
Azarnoff, DL; Cohlmia, JB; Gugler, R; Huffman, DH; Shoeman, DW	1
Petruch, F; Schüppel, RV	2
Levy, G; Soda, DM	1
Mützell, S	1
Fujii, E; Hirayanagi, N; Teshirogi, T	1
Humphries, TJ	1
Elyas, AA; Patsalos, PN; Zakrzewska, JM	1
Büchsel, R; Kohl, D; Kreiten, K; Matern, S; Wietholtz, H; Zysset, T	1
Hansen, JM; Jørgensen, B; Kayser, L; Perrild, H; Poulsen, HE; Skovsted, L	1
Dickinson, RG; Fowler, DW; Kluck, RM	1
Barre, J; Cournot, A; Duche, JC; Duchier, J; Guinot, P; Tillement, JP	1
Richens, A; Rimmer, EM	1
Abramson, FP	1
Bachmann, KA; Jahn, D; Schwartz, J; Yang, C	1
Weissel, M	1
Horikoshi, I; Kanamoto, I; Kodachi, M; Koizumi, T	1
Shrewsbury, RP	1
Hanano, M; Harashima, H; Iga, T; Sawada, Y; Sugiyama, Y	1
Hanano, M; Iga, T; Sawada, Y; Sugiyama, Y	1
Gugler, R; Jensen, JC	1
Dyas, J; Evans, PJ; Peters, JR; Riad-Fahmy, D; Rimmer, E; Scanlon, MF; Thomas, JP; Tsanaclis, L; Walker, RF	1
Hopkins, K; Houston, JB; Morselli, PL; Rowland, M; Shaw, PN; Thiercelin, JF	1
Passananti, GT; Vessell, ES	1
Estabrook, RW; Greim, H; Remmer, H; Schenkman, J	1
Vesell, ES	2
Evans, DA	1
Oldendorf, WH	1
Gajewska, M	1
Sotaniemi, EA	1
Petruch, F; Schüppel, RV; Steinhilber, G	1
Altland, K; Goedee, HW	1
Azarnoff, DL; Boulos, BM; Kauffman, RE; Shoeman, DW	1
Pelkonen, RO; Puukka, M; Sotaniemi, EA	1
Boxenbaum, H	1
Chan, HL	1
Christensen, LK; Hansen, JM; Hegedüs, L; Perrild, H; Simonsen, K; Skovsted, L	1
Hedges, A; Makki, KA; Perucca, E; Richens, A; Ruprah, M; Wilson, JF	1
Carruthers, SG; Freeman, DJ; Keown, PA; Laupacis, A; Stiller, CR	1
Laidlaw, J; Makki, K; Monks, A; Oxley, J; Richens, A	1
Chiba, K; Ishizaki, T; Nakazawa, Y; Tabuchi, T; Wagatsuma, T	1
Breimer, DD; Buruma, OJ; de Wolff, FA; Ferrari, MD; Vermeij, P	1
Fujioka, H; Tan, T	1
Goldberg, DM	1
Kalow, W	1
Belpaire, FM; Bogaert, MG; Rosseel, MT; Van Peer, AP	1
Kaste, M; Neuvonen, PJ; Tokola, RA	1
McDevitt, DG; Riddell, JG; Salem, SA	1
Bliesath, H; Hartmann, M; Huber, R; Radtke, HW; Steinijans, VW; Wurst, W; Zech, K	1
Brøsen, K; Dalhoff, K; Flachs, H; Loft, S; Poulsen, HE; Ranek, L; Wantzin, P	1
Bachmann, KA; Jauregui, L	1
Fendrich, Z; Jindrová, O; Láznícek, M; Staud, F	1
Allen, E; Reece, PA; Sedman, AJ; Tsanaclis, LM; Wroe, SJ	1
Kokue, E; Saitoh, T; Shimoda, M	1
ZAKHARIIA, EA; ZAPADNIUK, VI	1
Hu, C; Hu, X; Qu, J; Yang, M; Yuan, F	1
Hu, C; Li, YY; Nie, Y; Zhang, L	1

Reviews

15 review(s) available for phenytoin and antipyrine

Article	Year
[Modification of the action of drugs by inhibition of their metabolism]. Recenti progressi in medicina, 1979, Volume: 67, Issue:3 Topics: Antipyrine; Barbiturates; Drug Interactions; Enzyme Induction; Enzyme Repression; Ethanol; gamma-Glutamyltransferase; Glucaric Acid; Humans; Nicotine; Pharmaceutical Preparations; Pharmacology; Phenytoin; Rifampin	1979
Pharmacokinetic consequences of aging. Annual review of pharmacology and toxicology, 1977, Volume: 17 Topics: Adult; Aged; Aging; Aminopyrine; Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antipyrine; Barbiturates; Blood Proteins; Digoxin; Disease; Female; Humans; Intestinal Absorption; Kidney; Kinetics; Male; Middle Aged; Pharmaceutical Preparations; Phenytoin; Protein Binding; Rats	1977
Genetic factors in hepatic drug oxidation. Progress in liver diseases, 1976, Volume: 5 Topics: Animals; Antipyrine; Cytochrome P-450 Enzyme System; Humans; Liver; Lymphocytes; Male; Mammals; Mixed Function Oxygenases; Models, Biological; Nortriptyline; Oxidation-Reduction; Pharmaceutical Preparations; Phenytoin; Rats	1976
Drug protein binding and the nephrotic syndrome. Clinical pharmacokinetics, 1976, Volume: 1, Issue:1 Topics: Antipyrine; Blood Proteins; Clofibrate; Diazepam; Half-Life; Humans; Kinetics; Nephrotic Syndrome; Pharmaceutical Preparations; Phenytoin; Prednisone; Protein Binding; Serum Albumin	1976
Drug metabolism in uremia. Clinical nephrology, 1975, Volume: 4, Issue:3 Topics: Acetohexamide; Animals; Antipyrine; Humans; Hydrolysis; Lipid Metabolism; Microsomes, Liver; Oxidation-Reduction; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Procainamide; Rats; Tolbutamide; Uremia; Vitamin D	1975
Clinical implications of drug interactions with the cytochrome P-450 enzyme system associated with omeprazole. Digestive diseases and sciences, 1991, Volume: 36, Issue:12 Topics: Aminopyrine; Animals; Antipyrine; Cytochrome P-450 Enzyme System; Diazepam; Drug Interactions; Humans; Omeprazole; Phenytoin; Propranolol; Theophylline; Warfarin	1991
[Modification of peripheral thyroid hormone metabolism by drugs]. Acta medica Austriaca, 1988, Volume: 15 Suppl 1 Topics: Amiodarone; Antipyrine; Dexamethasone; Heparin; Humans; Phenobarbital; Phenytoin; Propranolol; Protein Binding; Rifampin; Thiouracil; Thyroxine; Thyroxine-Binding Proteins; Triiodothyronine	1988
Prediction of the disposition of nine weakly acidic and six weakly basic drugs in humans from pharmacokinetic parameters in rats. Journal of pharmacokinetics and biopharmaceutics, 1985, Volume: 13, Issue:5 Topics: Animals; Antipyrine; Barbiturates; Biological Availability; Chlorpromazine; Diazepam; Drug Evaluation; Female; Half-Life; Humans; Kinetics; Male; Metabolic Clearance Rate; Pentazocine; Pharmaceutical Preparations; Phenylbutazone; Phenytoin; Propranolol; Quinidine; Rats; Species Specificity; Tissue Distribution; Tolbutamide; Valproic Acid; Warfarin	1985
Utility of clinical chemical determinations of drug concentrations in biological fluids. Clinical chemistry, 1971, Volume: 17, Issue:9 Topics: Adult; Allopurinol; Antipyrine; Ataxia; Chemistry, Clinical; Chromatography, Gas; Coffee; Desipramine; Dicumarol; Drug Antagonism; Drug Synergism; Ethanol; Female; Fluorometry; Half-Life; Humans; Iatrogenic Disease; Male; Mental Disorders; Metabolism; Methods; Middle Aged; Morphine; Nortriptyline; Nystagmus, Pathologic; Pharmaceutical Preparations; Pharmacogenetics; Pharmacology; Phenobarbital; Phenylbutazone; Phenytoin; Pregnancy; Smoking; Spectrophotometry; Twins; Ultraviolet Rays	1971
Recent progress in pharmacogenetics. Advances in pharmacology, 1969, Volume: 7 Topics: Adult; Aged; Alcohol Oxidoreductases; Antipyrine; Asian People; Child, Preschool; Cholinesterases; Cyanides; Dicumarol; Diseases in Twins; Drug Hypersensitivity; Erythrocytes; Favism; Female; Glucosephosphate Dehydrogenase Deficiency; Hemoglobins; Humans; Isoniazid; Liver; Male; Metabolism, Inborn Errors; Middle Aged; Pharmacogenetics; Phenylbutazone; Phenylthiourea; Phenytoin; Pregnancy; Primaquine; Twins; Warfarin	1969
Recent progress in pharmacogenetics. Advances in pharmacology and chemotherapy, 1969, Volume: 7 Topics: Adult; Antipyrine; Cyanides; Dicumarol; Erythrocytes; Ethnicity; Female; Glucosephosphate Dehydrogenase Deficiency; Hemoglobins; Humans; Isoniazid; Male; Middle Aged; Mutation; Pharmacogenetics; Phenylbutazone; Phenylthiourea; Phenytoin; Pregnancy; Racial Groups; Taste; Twins	1969
[Genetically dependent variability of drug effects]. Medizinische Klinik, 1970, Aug-28, Volume: 65, Issue:35 Topics: Anemia, Hemolytic; Anesthesia, General; Anesthetics; Animals; Antipyrine; Apnea; Atropine; Body Temperature; Coumarins; Cyanosis; Deficiency Diseases; Dexamethasone; Dogs; Drug Tolerance; Enzymes; Female; Glucosephosphate Dehydrogenase; Humans; Intraocular Pressure; Isonicotinic Acids; Male; Meperidine; Mice; Oxyphenbutazone; Pharmacogenetics; Phenacetin; Phenylbutazone; Phenytoin; Proteins; Rabbits; Rats; Succinylcholine	1970
The expanding role of microsomal enzyme induction, and its implications for clinical chemistry. Clinical chemistry, 1980, Volume: 26, Issue:6 Topics: Acetaminophen; Alcoholism; Animals; Antipyrine; Aryl Hydrocarbon Hydroxylases; Electron Transport; Energy Intake; Enzyme Induction; Epilepsy; Female; Humans; Male; Microsomes, Liver; Pharmacology; Phenobarbital; Phenylbutazone; Phenytoin; Smoking; Tolbutamide; Warfarin	1980
The Upjohn Award Lecture 1981/La Conférence Upjohn 1981. The metabolism of xenobiotics in different populations. Canadian journal of physiology and pharmacology, 1982, Volume: 60, Issue:1 Topics: Antipyrine; Asian People; Biotransformation; Black People; Ethanol; Genetic Variation; Genetics, Population; Humans; Kinetics; Oxidoreductases; Pharmaceutical Preparations; Phenytoin; Racial Groups; White People	1982
Lack of pantoprazole drug interactions in man. International journal of clinical pharmacology and therapeutics, 1994, Volume: 32, Issue:8 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Absorption; Antipyrine; Benzimidazoles; Contraceptives, Oral, Hormonal; Cross-Over Studies; Cytochrome P-450 Enzyme System; Diazepam; Digoxin; Drug Interactions; Female; Humans; Liver; Longitudinal Studies; Male; Nifedipine; Omeprazole; Pantoprazole; Phenytoin; Proton Pump Inhibitors; Sulfoxides; Theophylline; Tissue Distribution; Warfarin	1994

Trials

5 trial(s) available for phenytoin and antipyrine

Article	Year
Differential effect of continuous administration of beta-adrenoceptor antagonists on antipyrine and phenytoin clearance. British journal of clinical pharmacology, 1989, Volume: 28, Issue:5 Topics: Adrenergic beta-Antagonists; Adult; Antipyrine; Atenolol; Humans; Male; Metoprolol; Phenytoin; Propranolol	1989
Effect of Ginkgo biloba extract on microsomal enzyme induction. International journal of clinical pharmacology research, 1989, Volume: 9, Issue:3 Topics: Adult; Antipyrine; Enzyme Induction; Half-Life; Humans; Male; Microsomes, Liver; Phenytoin; Plant Extracts	1989
Lack of pantoprazole drug interactions in man. International journal of clinical pharmacology and therapeutics, 1994, Volume: 32, Issue:8 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Absorption; Antipyrine; Benzimidazoles; Contraceptives, Oral, Hormonal; Cross-Over Studies; Cytochrome P-450 Enzyme System; Diazepam; Digoxin; Drug Interactions; Female; Humans; Liver; Longitudinal Studies; Male; Nifedipine; Omeprazole; Pantoprazole; Phenytoin; Proton Pump Inhibitors; Sulfoxides; Theophylline; Tissue Distribution; Warfarin	1994
Use of single sample clearance estimates of cytochrome P450 substrates to characterize human hepatic CYP status in vivo. Xenobiotica; the fate of foreign compounds in biological systems, 1993, Volume: 23, Issue:3 Topics: Administration, Oral; Adult; Antipyrine; Aryl Hydrocarbon Hydroxylases; Carbamazepine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Ethosuximide; Humans; Liver; Lorazepam; Male; Oxidoreductases, N-Demethylating; Phenobarbital; Phenytoin; Quinidine; Rifampin; Smoking; Theophylline; Valproic Acid	1993
Gabapentin does not affect antipyrine clearance. Journal of clinical pharmacology, 1999, Volume: 39, Issue:9 Topics: Acetates; Adult; Amines; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antipyrine; Cyclohexanecarboxylic Acids; Double-Blind Method; Drug Interactions; Gabapentin; gamma-Aminobutyric Acid; Half-Life; Humans; Male; Phenytoin; Saliva	1999

Other Studies

70 other study(ies) available for phenytoin and antipyrine

Article	Year
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk). Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9 Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water	2005
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. Journal of pharmaceutical sciences, 2005, Volume: 94, Issue:7 Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution	2005
QSAR study on permeability of hydrophobic compounds with artificial membranes. Bioorganic & medicinal chemistry, 2007, Jun-01, Volume: 15, Issue:11 Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship	2007
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors. Bioorganic & medicinal chemistry letters, 2009, Dec-01, Volume: 19, Issue:23 Topics: Amidohydrolases; Carbamates; Dose-Response Relationship, Drug; Drug Design; Enzyme Inhibitors; Humans; Models, Molecular; Molecular Structure; Piperazines; Stereoisomerism; Structure-Activity Relationship	2009
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Importance of physicochemical properties for the design of new pesticides. Journal of agricultural and food chemistry, 2011, Apr-13, Volume: 59, Issue:7 Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:2 Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols	2012
Drug concentration in saliva. Clinical pharmacology and therapeutics, 1978, Volume: 24, Issue:5 Topics: Adolescent; Adult; Aged; Antipyrine; Chlorpropamide; Humans; Hydrogen-Ion Concentration; Male; Meperidine; Middle Aged; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Propranolol; Protein Binding; Saliva; Tolbutamide	1978
Use of saliva in therapeutic drug monitoring. Clinical chemistry, 1977, Volume: 23, Issue:2 PT. 1 Topics: Antipyrine; Caffeine; Ethosuximide; Gas Chromatography-Mass Spectrometry; Humans; Immunoenzyme Techniques; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Primidone; Saliva; Theophylline	1977
Antiopyrine half-life as a measure of hepatic enzyme induction: clinical applications in a chronic epileptic population. Clinical and experimental neurology, 1979, Volume: 16 Topics: Adult; Antipyrine; Barbiturates; Enzyme Induction; Epilepsy; Female; Half-Life; Humans; Male; Microsomes, Liver; Osteomalacia; Patient Compliance; Phenytoin; Risk; Saliva	1979
Unaltered metabolism of phenytoin in thyroid disorders. Acta pharmacologica et toxicologica, 1978, Volume: 42, Issue:5 Topics: Adult; Aged; Antipyrine; Female; Half-Life; Humans; Hyperthyroidism; Hypothyroidism; Male; Middle Aged; Phenytoin; Thyroid Function Tests; Thyroxine	1978
In vitro hepatic oxidative metabolism of antipyrine, phenytoin and phenylbutazone in rabbits with experimental renal failure. Archives internationales de pharmacodynamie et de therapie, 1978, Volume: 234, Issue:2 Topics: Animals; Antipyrine; In Vitro Techniques; Kidney Failure, Chronic; Kinetics; Liver; Oxidation-Reduction; Phenylbutazone; Phenytoin; Rabbits	1978
Pharmacokinetics of drugs in rabbits with experimental acute renal failure. Pharmacology, 1978, Volume: 17, Issue:6 Topics: Acute Kidney Injury; Animals; Antipyrine; Blood Proteins; Female; Half-Life; Phenylbutazone; Phenytoin; Protein Binding; Rabbits; Uranyl Nitrate; Urea	1978
Drug distribution in renal failure. The American journal of medicine, 1977, Volume: 62, Issue:4 Topics: Antipyrine; Clofibrate; Dose-Response Relationship, Drug; Drug Tolerance; Humans; Kidney Failure, Chronic; Metabolic Clearance Rate; Nephrotic Syndrome; Pharmaceutical Preparations; Phenytoin; Protein Binding; Serum Albumin	1977
The metabolism of phenobarbitone, phenytoin and antipyrine in Black patients. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1977, Aug-27, Volume: 52, Issue:10 Topics: Adult; Antipyrine; Black People; Drug Interactions; Half-Life; Humans; Phenobarbital; Phenytoin; South Africa	1977
Letter: Antipyrine half life and clearance in clinical practice. British medical journal, 1976, Aug-21, Volume: 2, Issue:6033 Topics: Adult; Antipyrine; Drug Interactions; Female; Half-Life; Humans; Male; Phenytoin	1976
Pharmacokinetics of drugs in patients with the nephrotic syndrome. The Journal of clinical investigation, 1975, Volume: 55, Issue:6 Topics: Adult; Antipyrine; Blood Proteins; Body Weight; Clofibrate; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Nephrotic Syndrome; Phenytoin; Protein Binding	1975
[Effects of anticonvulsive treatment on drug elimination in man. Induction of liver hydroxylating enzyme system by diphenylhydantoin and carbamazepine]. Bibliotheca psychiatrica, 1975, Issue:151 Topics: Adult; Antipyrine; Bilirubin; Carbamazepine; Creatinine; Epilepsy; Female; Half-Life; Humans; Hydroxylation; Liver; Male; Middle Aged; Phenytoin; Time Factors; Trigeminal Neuralgia	1975
Inhibition of drug metabolism by hydroxylated metabolites: cross-inhibition and specificity. Journal of pharmaceutical sciences, 1975, Volume: 64, Issue:12 Topics: Animals; Antipyrine; Biotransformation; Depression, Chemical; Half-Life; Hydroxylation; Male; Oxidation-Reduction; Oxyphenbutazone; Pharmaceutical Preparations; Phenytoin; Rats; Sulfanilamides; Time Factors	1975
Computed tomography of the brain, hepatotoxic drugs and high alcohol consumption in male alcoholic patients and a random sample from the general male population. Upsala journal of medical sciences, 1992, Volume: 97, Issue:2 Topics: Adult; Aged; Alcoholism; Analgesics; Anti-Anxiety Agents; Anti-Arrhythmia Agents; Antipyrine; Aspirin; Barbiturates; Benzodiazepines; Brain Damage, Chronic; Cerebral Cortex; Cerebral Ventricles; Cerebral Ventriculography; Chi-Square Distribution; Chlormethiazole; Dextropropoxyphene; Drug Combinations; Drug Interactions; Humans; Ibuprofen; Liver; Liver Function Tests; Male; Middle Aged; Observer Variation; Pancreatic Function Tests; Phenothiazines; Phenytoin; Risk Factors; Sulfamethizole; Sulfamethoxypyridazine; Tomography, X-Ray Computed	1992
[The significance of serum gamma-glutamyl transpeptidase (gamma-GTP) elevation caused by antiepileptic drug(s). Using the antipyrine metabolic capacity as a parameter of microsomal enzyme activity]. Nihon Ika Daigaku zasshi, 1991, Volume: 58, Issue:5 Topics: Adolescent; Adult; Alanine Transaminase; Anticonvulsants; Antipyrine; Aspartate Aminotransferases; Child; Child, Preschool; Female; gamma-Glutamyltransferase; Humans; Male; Microsomes, Liver; Phenytoin	1991
Dose dependent enzyme induction by oxcarbazepine? European journal of clinical pharmacology, 1990, Volume: 39, Issue:2 Topics: Aged; Anticonvulsants; Antipyrine; Carbamazepine; Dose-Response Relationship, Drug; Enzyme Induction; Female; Humans; Liver; Male; Middle Aged; Oxcarbazepine; Phenytoin; Trigeminal Neuralgia	1990
Effect of phenytoin, carbamazepine, and valproic acid on caffeine metabolism. European journal of clinical pharmacology, 1989, Volume: 36, Issue:4 Topics: Adolescent; Adult; Aged; Antipyrine; Caffeine; Carbamazepine; Cytochrome P-450 Enzyme System; Enzyme Induction; Epilepsy; Female; Half-Life; Humans; Hydrocortisone; Male; Middle Aged; Phenytoin; Valproic Acid	1989
Maternofetal transfer of phenytoin, p-hydroxy-phenytoin and p-hydroxy-phenytoin-glucuronide in the perfused human placenta. Clinical and experimental pharmacology & physiology, 1989, Volume: 16, Issue:10 Topics: Animals; Antipyrine; Female; Humans; In Vitro Techniques; Male; Maternal-Fetal Exchange; Metabolic Clearance Rate; Perfusion; Phenytoin; Placenta; Pregnancy; Rats; Rats, Inbred Strains; Solubility	1989
Interaction between vigabatrin and phenytoin. British journal of clinical pharmacology, 1989, Volume: 27 Suppl 1 Topics: Adolescent; Adult; Aminocaproates; Anticonvulsants; Antipyrine; Blood Proteins; Drug Interactions; Female; Half-Life; Humans; Male; Middle Aged; Phenytoin; Protein Binding; Seizures; Vigabatrin	1989
Parallel induction of plasma alpha 1-acid glycoprotein concentration and antipyrine clearance by drugs. Progress in clinical and biological research, 1989, Volume: 300 Topics: Animals; Antipyrine; Chromatography, Gas; Colorimetry; Cytochrome P-450 Enzyme System; Dogs; Dose-Response Relationship, Drug; Enzyme Activation; Liver; Male; Metabolic Clearance Rate; Orosomucoid; Phenobarbital; Phenytoin	1989
The use of single sample clearance estimates to probe hepatic drug metabolism in rats. I. Xenobiotica; the fate of foreign compounds in biological systems, 1988, Volume: 18, Issue:2 Topics: Animals; Antipyrine; Liver; Male; Metabolic Clearance Rate; Mixed Function Oxygenases; Models, Biological; Pharmaceutical Preparations; Phenytoin; Rats; Rats, Inbred Strains; Theophylline; Valproic Acid; Warfarin	1988
[Effect of saikokeishi-to on the pharmacokinetics of phenytoin in rabbit]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1988, Volume: 108, Issue:8 Topics: Animals; Antipyrine; Drugs, Chinese Herbal; Male; Models, Biological; Phenytoin; Protein Binding; Rabbits	1988
Effect of Fluosol-DA hemodilution on the kinetics of hepatically eliminated drugs. Research communications in chemical pathology and pharmacology, 1987, Volume: 55, Issue:3 Topics: Animals; Antipyrine; Blood Substitutes; Drug Combinations; Fluorocarbons; Hemodilution; Hydroxyethyl Starch Derivatives; Indocyanine Green; Kinetics; Liver; Pharmaceutical Preparations; Phenytoin; Propranolol; Rats	1987
Prediction of serum concentration time course of quinidine in human using a physiologically based pharmacokinetic model developed from the rat. Journal of pharmacobio-dynamics, 1986, Volume: 9, Issue:2 Topics: Animals; Antipyrine; Half-Life; Hexobarbital; Humans; Kidney; Kinetics; Liver; Metabolic Clearance Rate; Models, Biological; Phenytoin; Quinidine; Rats; Time Factors	1986
Interaction between metronidazole and drugs eliminated by oxidative metabolism. Clinical pharmacology and therapeutics, 1985, Volume: 37, Issue:4 Topics: Administration, Oral; Adult; Antipyrine; Chromatography, Gas; Diazepam; Drug Interactions; Female; Half-Life; Humans; Infusions, Parenteral; Kinetics; Male; Metronidazole; Phenytoin	1985
Anticonvulsant therapy and cortisol elimination. British journal of clinical pharmacology, 1985, Volume: 20, Issue:2 Topics: Adult; Anticonvulsants; Antipyrine; Dexamethasone; Female; Humans; Hydrocortisone; Male; Metabolic Clearance Rate; Middle Aged; Phenytoin; Saliva	1985
Antipyrine metabolite kinetics in healthy human volunteers during multiple dosing of phenytoin and carbamazepine. British journal of clinical pharmacology, 1985, Volume: 20, Issue:6 Topics: Adult; Antipyrine; Biotransformation; Carbamazepine; Drug Interactions; Half-Life; Humans; Kinetics; Male; Phenytoin; Saliva	1985
Editorial: Drug metabolism in disease. Lancet (London, England), 1974, Apr-27, Volume: 1, Issue:7861 Topics: Alanine Transaminase; Anti-Bacterial Agents; Antipyrine; Half-Life; Humans; Kidney; Kidney Diseases; Liver; Liver Diseases; Nortriptyline; Pharmaceutical Preparations; Phenytoin	1974
Reaction of drugs with microsomal liver hydroxylase: its influence on drug action. Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie, 1968, Volume: 259, Issue:2 Topics: Aniline Compounds; Animals; Antipyrine; Benzopyrenes; Cytochromes; Dicumarol; Electron Transport; Enzyme Induction; Hexobarbital; Kinetics; Liver; Methylcholanthrene; Microsomes; Mixed Function Oxygenases; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Protein Binding; Prothrombin Time	1968
The hydroxylation of drugs- a pharmacogenetic problem? Proceedings of the Royal Society of Medicine, 1970, Volume: 63, Issue:2 Topics: Antipyrine; Dicumarol; Endoplasmic Reticulum; Liver; Mixed Function Oxygenases; Nortriptyline; Pharmacogenetics; Phenylbutazone; Phenytoin	1970
[Enhanced drug hydroxylation in man under diphenyl-hydantoin therapy]. Arzneimittel-Forschung, 1974, Volume: 24, Issue:7 Topics: Administration, Oral; Antipyrine; Biodegradation, Environmental; Creatinine; Epilepsy; Epilepsy, Tonic-Clonic; Half-Life; Humans; Hydroxylation; Liver; Male; Microsomes, Liver; Phenytoin; Stimulation, Chemical	1974
Brain uptake of metabolites and drugs following carotid arterial injections. Transactions of the American Neurological Association, 1971, Volume: 96 Topics: Acetates; Amino Acids; Animals; Antipyrine; Ascorbic Acid; Aspirin; Barbiturates; Blood-Brain Barrier; Brain; Caffeine; Chloroquine; Cyanides; Ethanol; Imipramine; Lactates; Mescaline; Morphine; Neurotransmitter Agents; Nicotine; Penicillin G; Pharmaceutical Preparations; Phenytoin; Procaine; Pyruvates; Rats	1971
Complexometric determination of various diazole derivatives with cupric picrate. Acta poloniae pharmaceutica, 1972, Volume: 29, Issue:4 Topics: Aminopyrine; Antipyrine; Azoles; Copper; Histamine; Hydrogen-Ion Concentration; Imidazoles; Indicators and Reagents; Methods; Metronidazole; Phenylbutazone; Phenytoin; Picrates; Structure-Activity Relationship; Tolazoline	1972
Effects of drug pretreatment on antipyrine levels in blood and tissues: an example of multiple drug interactions. Pharmacology, 1973, Volume: 10, Issue:5 Topics: Animals; Antipyrine; Brain; Brain Chemistry; Drug Interactions; Enzyme Induction; Half-Life; Kinetics; Liver; Male; Phenobarbital; Phenytoin; Proadifen; Rats; Time Factors	1973
Effect of diphenylhydantoin on hepatic drug hydroxylation. European journal of clinical pharmacology, 1974, Jul-26, Volume: 7, Issue:4 Topics: Adult; Antipyrine; Bilirubin; Colorimetry; Creatinine; Epilepsy; Half-Life; Humans; Hydroxylation; Jaundice; Liver; Male; Middle Aged; Pharmaceutical Preparations; Phenelzine; Phenytoin	1974
Placental transfer of diphenylhydantoin in the goat. Biochemical pharmacology, 1972, May-01, Volume: 21, Issue:9 Topics: Amniotic Fluid; Animals; Antipyrine; Blood Chemical Analysis; Blood Proteins; Chromatography, Gas; Electrophoresis; Female; Fetus; Gestational Age; Goats; Maternal-Fetal Exchange; Phenytoin; Pregnancy; Pregnancy, Animal	1972
In vitro hepatic oxidative metabolism of antipyrine, phenytoin and phenylbutazone in uraemic rabbits. The Journal of pharmacy and pharmacology, 1980, Volume: 32, Issue:2 Topics: Animals; Antipyrine; Female; In Vitro Techniques; Kinetics; Liver; Microsomes, Liver; Oxidation-Reduction; Phenylbutazone; Phenytoin; Rabbits; Uremia	1980
Measurement of hepatic drug-metabolizing enxyme activity in man. Comparison of three different assays. European journal of clinical pharmacology, 1980, Volume: 17, Issue:4 Topics: Adult; Aged; Antipyrine; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Glucaric Acid; Hepatitis; Histamine H1 Antagonists; Humans; Liver; Liver Cirrhosis; Male; Medroxyprogesterone; Middle Aged; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Prednisolone; Rifampin	1980
Interspecies variation in liver weight, hepatic blood flow, and antipyrine intrinsic clearance: extrapolation of data to benzodiazepines and phenytoin. Journal of pharmacokinetics and biopharmaceutics, 1980, Volume: 8, Issue:2 Topics: Animals; Anti-Anxiety Agents; Antipyrine; Benzodiazepines; Cattle; Dogs; Goats; Guinea Pigs; Haplorhini; Humans; Liver; Liver Circulation; Mice; Organ Size; Phenytoin; Rabbits; Rats; Sheep; Species Specificity; Swine	1980
Observations on drug-induced toxic epidermal necrolysis in Singapore. Journal of the American Academy of Dermatology, 1984, Volume: 10, Issue:6 Topics: Adult; Aged; Anti-Inflammatory Agents; Antipyrine; Barbiturates; Burns; Child; Diagnosis, Differential; Drug Eruptions; Female; Humans; Male; Middle Aged; Necrosis; Penicillamine; Phenytoin; Syndrome; Tetracycline	1984
Lack of stimulation of antipyrine and phenytoin metabolism by lithium carbonate in man. Acta pharmacologica et toxicologica, 1983, Volume: 52, Issue:4 Topics: Adult; Aged; Antipyrine; Drug Interactions; Female; Half-Life; Humans; Lithium; Lithium Carbonate; Male; Middle Aged; Mixed Function Oxygenases; Phenytoin	1983
A comparative study of the relative enzyme inducing properties of anticonvulsant drugs in epileptic patients. British journal of clinical pharmacology, 1984, Volume: 18, Issue:3 Topics: Anticonvulsants; Antipyrine; Carbamazepine; Enzyme Induction; Epilepsy; Female; Glucaric Acid; Half-Life; Humans; Immunoenzyme Techniques; Male; Microsomes, Liver; Phenobarbital; Phenytoin; Primidone; Valproic Acid	1984
Evaluation of cyclosporin-phenytoin interaction with observations on cyclosporin metabolites. British journal of clinical pharmacology, 1984, Volume: 18, Issue:6 Topics: Adult; Antipyrine; Biotransformation; Chromatography, High Pressure Liquid; Cyclosporins; Drug Interactions; Half-Life; Humans; Male; Phenytoin; Radioimmunoassay	1984
Effects of sodium valproate on the serum protein binding of phenytoin, and on liver enzyme activity. Monographs in neural sciences, 1980, Volume: 5 Topics: Antipyrine; Aspartate Aminotransferases; Blood Proteins; Glucaric Acid; Half-Life; Humans; Liver; Phenytoin; Protein Binding; Time Factors; Valproic Acid	1980
Antipyrine disposition in relation to lowered anticonvulsant plasma level during pregnancy. Obstetrics and gynecology, 1982, Volume: 60, Issue:5 Topics: Adult; Anticonvulsants; Antipyrine; Delivery, Obstetric; Dose-Response Relationship, Drug; Epilepsy; Female; Half-Life; Humans; Infant, Newborn; Metabolic Clearance Rate; Phenobarbital; Phenytoin; Postpartum Period; Pregnancy; Pregnancy Complications; Time Factors; Valproic Acid	1982
Impairment of phenytoin parahydroxylation as a cause of severe intoxication. Therapeutic drug monitoring, 1983, Volume: 5, Issue:2 Topics: Aged; Antipyrine; Debrisoquin; Humans; Hydroxylation; Kinetics; Male; Phenytoin	1983
Biopharmaceutical studies on hydantoin derivatives. III. Physico-chemical properties, dissolution behavior, and bioavailability of the molecular compound of 1-benzenesulfonyl-5,5-diphenylhydantoin and antipyrine. Journal of pharmacobio-dynamics, 1982, Volume: 5, Issue:7 Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Biological Availability; Chemical Phenomena; Chemistry; Dogs; Drug Combinations; Intestinal Absorption; Male; Phenytoin; Solubility	1982
Distribution of antipyrine, phenylbutazone and phenytoin in experimental renal failure. Pharmacology, 1981, Volume: 22, Issue:2 Topics: Acute Kidney Injury; Animals; Antipyrine; Blood Proteins; Female; Phenylbutazone; Phenytoin; Protein Binding; Rabbits; Tissue Distribution	1981
Binding of drugs in serum, blood cells and tissues of rabbits with experimental acute renal failure. Pharmacology, 1981, Volume: 22, Issue:2 Topics: Acute Kidney Injury; Animals; Antipyrine; Blood Cells; Blood Proteins; Female; Phenylbutazone; Phenytoin; Protein Binding; Rabbits; Tissue Distribution	1981
Cimetidine-phenytoin interaction: effect on serum phenytoin concentration and antipyrine test. European journal of clinical pharmacology, 1981, Volume: 21, Issue:3 Topics: Adult; Aged; Antipyrine; Cimetidine; Drug Interactions; Female; Guanidines; Humans; Kinetics; Male; Middle Aged; Phenytoin; Prospective Studies	1981
Interaction between phenytoin and dichloralphenazone [proceedings]. British journal of clinical pharmacology, 1980, Volume: 9, Issue:1 Topics: Aged; Antipyrine; Chloral Hydrate; Drug Interactions; Female; Half-Life; Humans; Phenytoin	1980
Drug metabolism and genetic polymorphism in subjects with previous halothane hepatitis. Scandinavian journal of gastroenterology, 1993, Volume: 28, Issue:8 Topics: Adult; Aged; Antipyrine; Chemical and Drug Induced Liver Injury; Complement C3; Female; Halothane; HLA Antigens; Humans; Male; Mephenytoin; Metronidazole; Middle Aged; Phenotype; Phenytoin; Polymorphism, Genetic; Sparteine	1993
Phenytoin transfer across the in situ perfused rat term placenta. Die Pharmazie, 1997, Volume: 52, Issue:11 Topics: Analgesics; Animals; Anticonvulsants; Antipyrine; Blood Proteins; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Female; Perfusion; Phenytoin; Placenta; Pregnancy; Protein Binding; Rats; Rats, Wistar	1997
The impact of acute phase response on the plasma clearance of antipyrine, theophylline, phenytoin and nifedipine in rabbits. Journal of veterinary pharmacology and therapeutics, 2000, Volume: 23, Issue:3 Topics: Acute-Phase Reaction; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antipyrine; Area Under Curve; Chromatography, High Pressure Liquid; Escherichia coli; Female; Half-Life; Injections, Intramuscular; Interleukin-6; Lipopolysaccharides; Metabolic Clearance Rate; Nifedipine; Phenytoin; Protein Binding; Rabbits; Theophylline; Vasodilator Agents	2000
[THE REPRODUCTION OF AUDIOGENIC CONVULSIONS AFTER THE PRELIMINARY ADMINISTRATION OF PYRAMIDONE TO ANIMALS]. Biulleten' eksperimental'noi biologii i meditsiny, 1964, Volume: 57 Topics: Acetazolamide; Aminopyrine; Anticonvulsants; Antipyrine; Epilepsy, Reflex; Mice; Pharmacology; Phenobarbital; Phenytoin; Primidone; Rats; Research; Seizures; Sound; Toxicology	1964
Degradation of selected pharmaceuticals in aqueous solution with UV and UV/H(2)O(2). Water research, 2009, Volume: 43, Issue:6 Topics: Antipyrine; Biodegradation, Environmental; Diphenhydramine; Hydrogen Peroxide; Ibuprofen; Kinetics; Oxidation-Reduction; Pesticide Residues; Phenytoin; Photochemistry; Photolysis; Spectrophotometry, Ultraviolet; Water Pollutants, Chemical	2009
Enhanced Fenton-like degradation of refractory organic compounds by surface complex formation of LaFeO(3) and H(2)O(2). Journal of hazardous materials, 2015, Aug-30, Volume: 294 Topics: 2,4-Dichlorophenoxyacetic Acid; Acyclovir; Antipyrine; Catalysis; Chlorophenols; Hydrogen Peroxide; Oxides; Phenytoin; Sulfamethoxazole; Waste Disposal, Fluid; Water Pollutants, Chemical; Water Purification	2015