phenytoin has been researched along with 8-hydroxy-2'-deoxyguanosine in 2 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wells, PG; Winn, LM | 1 |
| Liu, L; Wells, PG | 1 |
2 other study(ies) available for phenytoin and 8-hydroxy-2'-deoxyguanosine
| Article | Year |
|---|---|
Phenytoin-initiated DNA oxidation in murine embryo culture, and embryo protection by the antioxidative enzymes superoxide dismutase and catalase: evidence for reactive oxygen species-mediated DNA oxidation in the molecular mechanism of phenytoin teratogen
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Catalase; Culture Media; Culture Techniques; Deoxyguanosine; DNA; Embryo, Mammalian; Female; Kinetics; Mice; Oxidation-Reduction; Phenytoin; Pregnancy; Reactive Oxygen Species; Superoxide Dismutase; Teratogens | 1995 |
DNA oxidation as a potential molecular mechanism mediating drug-induced birth defects: phenytoin and structurally related teratogens initiate the formation of 8-hydroxy-2'-deoxyguanosine in vitro and in vivo in murine maternal hepatic and embryonic tissue
Topics: 8-Hydroxy-2'-Deoxyguanosine; Abnormalities, Drug-Induced; Alkaline Phosphatase; Animals; Biotransformation; Deoxyguanosine; DNA; DNA Damage; Escherichia coli; Female; Horseradish Peroxidase; Humans; Kinetics; Liver; Mice; Mice, Inbred Strains; Phenytoin; Pregnancy; Teratogens; Xenobiotics | 1995 |