phenytoin has been researched along with 5-(3-hydroxyphenyl)-5-phenylhydantoin in 25 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (56.00) | 18.7374 |
| 1990's | 9 (36.00) | 18.2507 |
| 2000's | 2 (8.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Butler, TC; Dudley, KH; Kraus, BL; Maguire, JH | 1 |
| Eto, S; Noda, A; Noda, H | 2 |
| Hsieh, CY; Huang, JD | 1 |
| Eto, S; Minemoto, M; Mizukami, Y; Noda, A; Noda, H | 1 |
| Graves, NM; Miller, SA; Remmel, RP | 1 |
| Bliss, M; Gear, K; Hoyer, GL; Marcus, FI; Nolan, PE | 1 |
| Richens, A; Rimmer, EM | 1 |
| Lewis, LM; Oliver, SR; Shrewsbury, RP | 1 |
| Glazko, AJ | 1 |
| Dahllöf, G; Modéer, T; Otteskog, P | 2 |
| el-Sayed, YM; Islam, SI; Mira, SA | 1 |
| Frey, BM; Fritz, S; Küpfer, A; Lindner, W; Roots, I | 1 |
| Geary, WA; Lothman, EW; Perlin, JB; Wooten, GF | 1 |
| Maguire, JH; McClanahan, JS | 1 |
| Aronson, JK; Carver, JG; Davies, CL; Geaney, DP | 1 |
| Hermansson, J; Iversen, T; Lindquist, U | 1 |
| Buchanan, RA; Chang, T; Dill, WA; Glazko, AJ; Peterson, FE; Smith, TC | 1 |
| Bloem, BR; de Wolff, FA; Ferrari, MD; Kuiper, MA; Peeters, EA; Roos, RA; Vermeij, P; Wolters, EC | 1 |
| Goto, W; Higuchi, S; Hirata, K; Ieiri, I; Imayama, S; Ohtsubo, K; Ohyama, Y; Toshitani, A; Yamada, H | 1 |
| Inubushi, M; Misawa, S; Sakamoto, N; Tanaka, E | 1 |
| Kim, PM; Parman, T; Wells, PG; Winn, LM | 1 |
| Birks, EK; Guan, F; Rudy, JA; Soma, LR; Teleis, DC; Tsang, DS; Uboh, CE; Watson, AO | 1 |
| Komatsu, T; Nakajima, M; Yamazaki, H; Yokoi, T | 1 |
1 trial(s) available for phenytoin and 5-(3-hydroxyphenyl)-5-phenylhydantoin
| Article | Year |
|---|---|
The effect of 5-(p-hydroxyphenyl)-5-phenylhydantoin (p-HPPH) enantiomers, major metabolites of phenytoin, on the occurrence of chronic side effects: in vivo and in vitro studies.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Cell Division; Chronic Disease; DNA; Female; Fibroblasts; Humans; Male; Middle Aged; Phenytoin; Stereoisomerism | 1995 |
24 other study(ies) available for phenytoin and 5-(3-hydroxyphenyl)-5-phenylhydantoin
| Article | Year |
|---|---|
Determination of 5-(3,4-Dihydroxy-1,5-cyclohexadien-1-yl)-5-phenylhydantoin (Dihydrodiol) and quantitative studies of phenytoin metabolism in man.
Topics: Chromatography, Gas; Glucuronidase; Humans; Phenytoin | 1979 |
Chiral separation of barbiturates and hydantoins by reversed-phase high-performance liquid chromatography using a 25 or 50 mm short ODS cartridge column via beta-cyclodextrin inclusion complexes.
Topics: Barbiturates; beta-Cyclodextrins; Chromatography, High Pressure Liquid; Cyclodextrins; Humans; Hydantoins; Mephobarbital; Phenytoin; Stereoisomerism | 1992 |
Two-dimensional high-performance liquid chromatographic method to assay p-hydroxyphenylphenylhydantoin enantiomers in biological fluids and stereoselectivity of enzyme induction in phenytoin metabolism.
Topics: Acetone; Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Chromatography, High Pressure Liquid; Cimetidine; Dexamethasone; Diazepam; Enzyme Induction; Female; Ketoconazole; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Phenytoin; Rats; Safrole; Sex Characteristics; Stereoisomerism; Sulfaphenazole | 1992 |
High-performance liquid chromatographic method for direct separation of 5-(p-hydroxyphenyl)-5-phenylhydantoin enantiomers using a chiral tris(4-methylbenzoate) column.
Topics: Animals; Benzoates; Chromatography, High Pressure Liquid; Liver; Male; Phenytoin; Rats; Rats, Inbred Strains | 1991 |
Optical separation of racemic 5-(p-hydroxyphenyl)-5-phenylhydantoin by reversed phase high-performance liquid chromatography using eluents containing beta-cyclodextrin.
Topics: Animals; Chromatography, High Pressure Liquid; Cyclodextrins; Liver; Phenytoin; Rats; Spectrophotometry, Ultraviolet; Stereoisomerism | 1991 |
Simultaneous assay of felbamate plus carbamazepine, phenytoin, and their metabolites by liquid chromatography with mobile phase optimization.
Topics: Carbamazepine; Chromatography, High Pressure Liquid; Felbamate; Humans; Phenylcarbamates; Phenytoin; Propylene Glycols | 1990 |
Pharmacokinetic interaction between intravenous phenytoin and amiodarone in healthy volunteers.
Topics: Administration, Oral; Adult; Amiodarone; Drug Interactions; Humans; Infusions, Intravenous; Male; Phenytoin | 1989 |
Interaction between vigabatrin and phenytoin.
Topics: Adolescent; Adult; Aminocaproates; Anticonvulsants; Antipyrine; Blood Proteins; Drug Interactions; Female; Half-Life; Humans; Male; Middle Aged; Phenytoin; Protein Binding; Seizures; Vigabatrin | 1989 |
Effect of moderate haemodilution with Fluosol-DA or normal saline on low-dose phenytoin and (+/-)-5-(4-hydroxyphenyl)-5-phenylhydantoin kinetics.
Topics: Animals; Drug Combinations; Fluorocarbons; Hematocrit; Hemodilution; Hydroxyethyl Starch Derivatives; Kinetics; Male; Models, Biological; Phenytoin; Rats; Rats, Inbred Strains | 1987 |
Early adventures in drug metabolism: 4. Diphenylhydantoin (phenytoin).
Topics: Animals; Dose-Response Relationship, Drug; Glucuronates; Humans; Hydroxylation; Macaca mulatta; Phenytoin; Prodrugs | 1987 |
Phenytoin potentiates accessory cell dependent DNA-synthesis in human lymphocytes in vitro.
Topics: Adult; Cells, Cultured; Concanavalin A; DNA; Humans; Interleukin-2; Lymphocytes; Phenytoin; T-Lymphocytes | 1986 |
Simultaneous measurement of phenobarbital, carbamazepine, phenytoin and 5-(4-hydroxyphenyl)-5-phenylhydantoin in serum by high-performance liquid chromatography.
Topics: Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Humans; Phenobarbital; Phenytoin | 1987 |
Stereochemistry of aromatic phenytoin hydroxylation in various drug hydroxylation phenotypes in humans.
Topics: Adult; Chromatography, High Pressure Liquid; Epilepsy; Epoxy Compounds; Female; Glucuronates; Humans; Hydroxylation; Kinetics; Male; Middle Aged; Phenotype; Phenytoin; Stereoisomerism | 1987 |
In vitro and in vivo distribution and binding of phenytoin to rat brain.
Topics: Animals; Autoradiography; Brain; Chromatography, Thin Layer; Kinetics; Phenytoin; Rats; Time Factors; Tissue Distribution | 1987 |
High-performance liquid chromatographic determination of the enantiomeric composition of urinary phenolic metabolites of phenytoin.
Topics: Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Humans; Phenytoin; Stereoisomerism | 1986 |
Pharmacokinetic investigation of the interaction of azapropazone with phenytoin.
Topics: Adult; Apazone; Drug Interactions; Humans; Kinetics; Male; Phenytoin; Protein Binding; Saliva; Triazines | 1983 |
The effect of the phenytoin metabolite p-HPPH on proliferation of gingival fibroblasts in vitro.
Topics: Cell Division; Fibroblasts; Gingiva; Gingival Hyperplasia; Humans; Phenytoin; Time Factors | 1982 |
Isolation and determination of the diastereomers of the glucuronidated 5-(4-hydroxyphenyl)-5-phenylhydantoin in human urine using HPLC.
Topics: Animals; Chromatography, High Pressure Liquid; Female; Glucuronates; Humans; Phenytoin; Rats; Rats, Inbred Strains; Stereoisomerism | 1982 |
Phenytoin metabolism in subjects with long and short plasma half-lives.
Topics: Adult; Half-Life; Humans; Male; Middle Aged; Phenytoin | 1982 |
Phenytoin parahydroxylation is not impaired in patients with young-onset Parkinson's disease.
Topics: Administration, Oral; Adult; Age Factors; Cytochrome P-450 Enzyme System; Female; Humans; Hydroxylation; Inactivation, Metabolic; Isoenzymes; Male; Metabolic Clearance Rate; Middle Aged; Parkinson Disease; Phenytoin; Reference Values | 1994 |
Simultaneous determination of plasma phenytoin and its primary hydroxylated metabolites in carbon tetrachloride-intoxicated rats by high-performance liquid chromatography.
Topics: Animals; Anticonvulsants; Carbon Tetrachloride; Chromatography, High Pressure Liquid; Male; Phenytoin; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry | 1995 |
UDP-glucuronosyltransferase-mediated protection against in vitro DNA oxidation and micronucleus formation initiated by phenytoin and its embryotoxic metabolite 5-(p-hydroxyphenyl)-5-phenylhydantoin.
Topics: Animals; Anticonvulsants; Cells, Cultured; Chromatography, High Pressure Liquid; DNA; Embryo, Mammalian; Female; Glucuronosyltransferase; Male; Mice; Micronuclei, Chromosome-Defective; Organ Culture Techniques; Oxidation-Reduction; Phenytoin; Rats; Rats, Gunn; Rats, Wistar | 1997 |
Disposition, elimination, and bioavailability of phenytoin and its major metabolite in horses.
Topics: Administration, Oral; Animals; Anticonvulsants; Area Under Curve; Biological Availability; Cross-Over Studies; Female; Half-Life; Horses; Injections, Intravenous; Phenytoin; Random Allocation; Statistics, Nonparametric | 2001 |
Identification of catalase in human livers as a factor that enhances phenytoin dihydroxy metabolite formation by human liver microsomes.
Topics: Catalase; Cytochrome P-450 Enzyme System; Cytosol; Humans; Hydroxylation; Liver; Microsomes, Liver; Phenytoin; Recombinant Proteins | 2002 |