phenylmercuric-acetate and flunixin

phenylmercuric-acetate has been researched along with flunixin* in 1 studies

Other Studies

1 other study(ies) available for phenylmercuric-acetate and flunixin

Article	Year
The effect of drugs used in the treatment of osteoarthrosis on stromelysin (proteoglycanase) of equine synovial cell origin. Equine veterinary journal. Supplement, 1988, Issue:6 There is increasing evidence that the proteoglycan-degrading neutral metalloproteinase, stromelysin, is a key enzyme in the pathogenesis of osteoarthrosis. Equine synovial lining cells were stimulated in vitro to produce stromelysin, and phenylbutazone, flunixin, betamethasone, sodium hyaluronate and polysulphated glycosaminoglycan (PSGAG) were tested for their ability to inhibit the action of this enzyme on 14C-labelled casein substrate. Only PSGAG possessed inhibitory activity at concentrations likely to be achieved therapeutically in the equine fetlock joint. Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Betamethasone; Clonixin; Dose-Response Relationship, Drug; Enzyme Activation; Glycosaminoglycans; Horse Diseases; Horses; Hyaluronic Acid; Matrix Metalloproteinase 3; Matrix Metalloproteinase Inhibitors; Osteoarthritis; Phenylbutazone; Phenylmercuric Acetate; Trypsin	1988

Article

Year

The effect of drugs used in the treatment of osteoarthrosis on stromelysin (proteoglycanase) of equine synovial cell origin.

Equine veterinary journal. Supplement, 1988, Issue:6

There is increasing evidence that the proteoglycan-degrading neutral metalloproteinase, stromelysin, is a key enzyme in the pathogenesis of osteoarthrosis. Equine synovial lining cells were stimulated in vitro to produce stromelysin, and phenylbutazone, flunixin, betamethasone, sodium hyaluronate and polysulphated glycosaminoglycan (PSGAG) were tested for their ability to inhibit the action of this enzyme on 14C-labelled casein substrate. Only PSGAG possessed inhibitory activity at concentrations likely to be achieved therapeutically in the equine fetlock joint.

Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Betamethasone; Clonixin; Dose-Response Relationship, Drug; Enzyme Activation; Glycosaminoglycans; Horse Diseases; Horses; Hyaluronic Acid; Matrix Metalloproteinase 3; Matrix Metalloproteinase Inhibitors; Osteoarthritis; Phenylbutazone; Phenylmercuric Acetate; Trypsin

1988