phenylbutazone and flunixin meglumine

phenylbutazone has been researched along with flunixin meglumine in 40 studies

Research

Studies (40)

TimeframeStudies, this research(%)All Research%
pre-19908 (20.00)18.7374
1990's15 (37.50)18.2507
2000's8 (20.00)29.6817
2010's5 (12.50)24.3611
2020's4 (10.00)2.80

Authors

AuthorsStudies
Coyne, CP; Erickson, HH; Lowe, BS; Olsen, SC; Pelletier, N; Raub, EM1
Brown, MP; Gronwall, R; Merritt, K; Zertuche, JM1
Strøm, H; Thomsen, MK1
Ahl, AS; Kopcha, M1
St George, TD; Uren, MF; Zakrzewski, H1
Hardee, GE; Hardee, MM; Moore, JN2
Pätilä, J; Pyörälä, S; Sandholm, M1
Erb, HN; Faulkner, LW; King, JM1
Johnstone, IB1
Snow, D1
Booker, CA; Chiffelle, CL; Dascanio, JJ; Gröhn, YT; Kenney, DG; Mechor, GD; Musser, JM; Thompson, P; Warnick, LD1
White, NA1
Alvinerie, M; Autefage, A; Legrand, C; Toutain, PL1
Ashcraft, SM; Harris, ON; Sams, RA; Semrad, SD1
Borne, AT; MacAllister, CG; Morgan, SJ; Pollet, RA1
Andersen, PH; Baek, L; Hesselholt, M; Jarløv, N1
Bochsler, PN; Dean, DF; Olchowy, TW1
Fox, SM; Johnston, SA1
Craigmill, AL; Damian, P; Riviere, JE1
Cheng, Z; McKellar, QA; Nolan, AM1
Cheng, Z; McKeller, Q; Nolan, A1
Harmon, FA; Rakestraw, PC; Snyder, JR; Van Hoogmoed, L1
Bertone, AL; Hardy, J; Moses, VS; Weisbrode, SE1
Brideau, C; Chan, CC; Van Staden, C1
Bryant, CE; Farnfield, BA; Janicke, HJ1
Clarke, CR; Erkert, RS; MacAllister, CG; Payton, ME1
Keegan, KG; Messer, NT; Reed, SK; Tessman, RK1
Hart, J; Mogg, TD; Wearn, J1
Keegan, KG; Kramer, J; Messer, NT; Reed, SK; Wilson, DA1
Davis, JL; Riviere, JE; Smith, GW; Tell, LA; Webb, AI1
Ball, KT; Banner, SE; Foreman, JH; Grubb, TL; Inoue, OJ1
Derakhshanfar, A; Mozaffari, AA1
Foreman, JH; Ruemmler, R1
Clark-Price, SC; Gutierrez-Nibeyro, SD; Santos, MP1
Burkett, BN; Fontenot, RL; Hurdle, HM; Thomason, JM; Wills, RW1
Arthur, RM; Baden, RW; Kass, PH; Knych, HK; McKemie, DS; Seminoff, K1
Arthur, RM; Baden, R; Finno, CJ; Knych, HK; McKemie, DS1
Brunner, TJ; Cooper, BR; Davern, AJ; Grady, SE; Lescun, TB; Moore, GE; Taylor, SD1
Csereklye, N; Makra, Z; McMullen, RJ; Riera, MM; Veres-Nyéki, K1

Reviews

3 review(s) available for phenylbutazone and flunixin meglumine

ArticleYear
Experimental uses of flunixin meglumine and phenylbutazone in food-producing animals.
    Journal of the American Veterinary Medical Association, 1989, Jan-01, Volume: 194, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cattle; Cattle Diseases; Chickens; Clonixin; Goats; Nicotinic Acids; Phenylbutazone; Poultry Diseases; Respiratory Tract Diseases; Sheep; Swine; Swine Diseases

1989
Use of carprofen for the treatment of pain and inflammation in dogs.
    Journal of the American Veterinary Medical Association, 1997, May-15, Volume: 210, Issue:10

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carbazoles; Clonixin; Cyclooxygenase Inhibitors; Dog Diseases; Dogs; Ibuprofen; Indomethacin; Ketoprofen; Meclofenamic Acid; Meloxicam; Naproxen; Osteoarthritis; Pain; Phenylbutazone; Piroxicam; Thiazines; Thiazoles

1997
Extralabel use of nonsteroidal anti-inflammatory drugs.
    Journal of the American Veterinary Medical Association, 1997, Oct-01, Volume: 211, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cattle; Clonixin; Dipyrone; Drug Approval; Drug Residues; Drug Utilization; Food Contamination; Goats; Ketoprofen; Meat; Milk; Phenylbutazone; Sheep; United States; United States Food and Drug Administration

1997

Trials

8 trial(s) available for phenylbutazone and flunixin meglumine

ArticleYear
Effect of phenylbutazone and flunixin meglumine on acute toxic mastitis in dairy cows.
    American journal of veterinary research, 1995, Volume: 56, Issue:9

    Topics: Acute Disease; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Appetite; Bacteria; Body Temperature; Cattle; Clonixin; Double-Blind Method; Escherichia coli; Escherichia coli Infections; Female; Gastrointestinal Motility; Gentamicins; Heart Rate; Infusions, Parenteral; Klebsiella; Klebsiella Infections; Lactation; Mastitis, Bovine; Milk; Phenylbutazone; Respiration; Rumen

1995
Effects of phenylbutazone alone or in combination with flunixin meglumine on blood protein concentrations in horses.
    American journal of veterinary research, 2006, Volume: 67, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Proteins; Clonixin; Drug Therapy, Combination; Female; Horse Diseases; Horses; Hypoalbuminemia; Hypoproteinemia; Male; Phenylbutazone; Stomach Ulcer

2006
Effectiveness of administration of phenylbutazone alone or concurrent administration of phenylbutazone and flunixin meglumine to alleviate lameness in horses.
    American journal of veterinary research, 2008, Volume: 69, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Clonixin; Cross-Over Studies; Drug Therapy, Combination; Female; Horse Diseases; Horses; Lameness, Animal; Male; Phenylbutazone

2008
Efficacy of single-dose intravenous phenylbutazone and flunixin meglumine before, during and after exercise in an experimental reversible model of foot lameness in horses.
    Equine veterinary journal. Supplement, 2010, Issue:38

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Clonixin; Drug Administration Schedule; Female; Horse Diseases; Horses; Lameness, Animal; Phenylbutazone; Physical Conditioning, Animal; Shoes

2010
Effects of Firocoxib, Flunixin Meglumine, and Phenylbutazone on Platelet Function and Thromboxane Synthesis in Healthy Horses.
    Veterinary surgery : VS, 2016, Volume: 45, Issue:8

    Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Clonixin; Cross-Over Studies; Female; Horses; Male; Phenylbutazone; Sulfones; Thromboxanes

2016
Pharmacokinetics and anti-inflammatory effects of flunixin meglumine as a sole agent and in combination with phenylbutazone in exercised Thoroughbred horses.
    Equine veterinary journal, 2021, Volume: 53, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, Liquid; Clonixin; Horses; Phenylbutazone; Tandem Mass Spectrometry

2021
Ketorolac Is Not More Effective Than Flunixin Meglumine or Phenylbutazone in Reducing Foot Pain in Horses.
    Journal of equine veterinary science, 2020, Volume: 94

    Topics: Animals; Clonixin; Cross-Over Studies; Horse Diseases; Horses; Ketorolac; Lameness, Animal; Pain; Phenylbutazone

2020
Effects of Intravenous Flunixin Meglumine, Phenylbutazone, and Acupuncture on Ocular Pain Scores in the Horse: A Pilot Study.
    Journal of equine veterinary science, 2021, Volume: 98

    Topics: Acupuncture Therapy; Animals; Anti-Inflammatory Agents, Non-Steroidal; Clonixin; Horses; Pain; Phenylbutazone; Pilot Projects

2021

Other Studies

29 other study(ies) available for phenylbutazone and flunixin meglumine

ArticleYear
Influence of cyclooxygenase inhibitors on furosemide-induced hemodynamic effects during exercise in horses.
    American journal of veterinary research, 1992, Volume: 53, Issue:9

    Topics: Animals; Blood Pressure; Clonixin; Heart Rate; Hemodynamics; Horses; Lactates; Male; Phenylbutazone; Physical Exertion; Random Allocation

1992
Effect of probenecid on the pharmacokinetics of flunixin meglumine and phenylbutazone in healthy mares.
    American journal of veterinary research, 1992, Volume: 53, Issue:3

    Topics: Animals; Clonixin; Drug Interactions; Female; Horses; Phenylbutazone; Probenecid

1992
Effects of non-steroidal anti-inflammatory drugs on canine neutrophil chemotaxis.
    Journal of veterinary pharmacology and therapeutics, 1990, Volume: 13, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemotaxis, Leukocyte; Clonixin; Dogs; Dose-Response Relationship, Drug; Indomethacin; Leukotriene B4; Masoprocol; Neutrophils; Phenylbutazone

1990
The effect of anti-inflammatory agents on the clinical expression of bovine ephemeral fever.
    Veterinary microbiology, 1989, Volume: 19, Issue:2

    Topics: Animals; Cattle; Cell Line; Clonixin; Cytopathogenic Effect, Viral; Ephemeral Fever; Fever; Nicotinic Acids; Phenylbutazone; Rhabdoviridae; Vero Cells; Viremia

1989
Modulation of arachidonic acid metabolism in endotoxic horses: comparison of flunixin meglumine, phenylbutazone, and a selective thromboxane synthetase inhibitor.
    American journal of veterinary research, 1986, Volume: 47, Issue:1

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Clonixin; Endotoxins; Escherichia coli; Horses; Imidazoles; Lactates; Male; Nicotinic Acids; Phenylbutazone; Thromboxane B2; Thromboxane-A Synthase

1986
Phenylbutazone and flunixin meglumine fail to show beneficial effects on bovine subclinical mastitis.
    Acta veterinaria Scandinavica, 1988, Volume: 29, Issue:3-4

    Topics: Acetylglucosaminidase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cattle; Clonixin; Female; Mastitis, Bovine; Milk; Nicotinic Acids; Phenylbutazone

1988
Effects of flunixin meglumine, phenylbutazone and a selective thromboxane synthetase inhibitor (UK-38,485) on thromboxane and prostacyclin production in healthy horses.
    Research in veterinary science, 1986, Volume: 40, Issue:2

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Clonixin; Epoprostenol; Horses; Imidazoles; Male; Nicotinic Acids; Orchiectomy; Phenylbutazone; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase

1986
Renal papillary necrosis in equines.
    Bulletin of environmental contamination and toxicology, 1984, Volume: 33, Issue:4

    Topics: Animals; Clonixin; Horse Diseases; Horses; Kidney Papillary Necrosis; Nicotinic Acids; Phenylbutazone

1984
Comparative effects of phenylbutazone, naproxen and flunixin meglumine on equine platelet aggregation and platelet factor 3 availability in vitro.
    Canadian journal of comparative medicine : Revue canadienne de medecine comparee, 1983, Volume: 47, Issue:2

    Topics: Adenosine Diphosphate; Animals; Blood Coagulation Factors; Blood Platelets; Clonixin; Collagen; Horses; Humans; In Vitro Techniques; Naproxen; Nicotinic Acids; Phenylbutazone; Platelet Aggregation; Platelet Factor 3

1983
Non-steroidal anti-inflammatory agents in the horse.
    In practice, 1981, Volume: 3, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Clonixin; Horse Diseases; Horses; Inflammation; Meclofenamic Acid; Naproxen; Phenylbutazone

1981
AVMA/Practice Group perspectives: use of drug labels in the prescription of antimicrobial therapy. Representing the American Association of Equine Practitioners (AAEP).
    Journal of the American Veterinary Medical Association, 1995, Oct-01, Volume: 207, Issue:7

    Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Cephalosporins; Clonixin; Drug Labeling; Gentamicins; Horse Diseases; Horses; Phenylbutazone; Societies; United States; Veterinary Medicine

1995
Plasma concentrations and therapeutic efficacy of phenylbutazone and flunixin meglumine in the horse: pharmacokinetic/pharmacodynamic modelling.
    Journal of veterinary pharmacology and therapeutics, 1994, Volume: 17, Issue:6

    Topics: Animals; Arthritis, Experimental; Clonixin; Dose-Response Relationship, Drug; Female; Horses; Male; Models, Biological; Phenylbutazone; Skin Temperature

1994
Effects of concurrent administration of phenylbutazone and flunixin meglumine on pharmacokinetic variables and in vitro generation of thromboxane B2 in mares.
    American journal of veterinary research, 1993, Volume: 54, Issue:11

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Clonixin; Drug Interactions; Female; Horse Diseases; Horses; In Vitro Techniques; Phenylbutazone; Thromboxane B2

1993
Comparison of adverse effects of phenylbutazone, flunixin meglumine, and ketoprofen in horses.
    Journal of the American Veterinary Medical Association, 1993, Jan-01, Volume: 202, Issue:1

    Topics: Animals; Anorexia; Blood Proteins; Clonixin; Female; Gastric Mucosa; Gastroscopy; Horse Diseases; Horses; Ketoprofen; Kidney Pelvis; Male; Mouth Diseases; Mouth Mucosa; Necrosis; Phenylbutazone; Random Allocation; Stomach Diseases

1993
Studies on in vivo endotoxin plasma disappearance times in cattle.
    Zentralblatt fur Veterinarmedizin. Reihe A, 1996, Volume: 43, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cattle; Clonixin; Endotoxins; Female; Lipidoses; Liver Diseases; Phenylbutazone

1996
Attempt to pharmacologically modulate procoagulant activity of lipopolysaccharide-stimulated adherent bovine alveolar macrophages.
    American journal of veterinary research, 1996, Volume: 57, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Cattle; Cell Adhesion; Cells, Cultured; Clonixin; Dexamethasone; Lipopolysaccharides; Macrophages, Alveolar; Male; Phenylbutazone; Time Factors

1996
Measurement of cyclooxygenase inhibition in vivo: a study of two non-steroidal anti-inflammatory drugs in sheep.
    Inflammation, 1998, Volume: 22, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Clonixin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diffusion Chambers, Culture; Dinoprostone; Inflammation; Isoenzymes; Leukocyte Count; Leukotriene B4; Male; Phenylbutazone; Prostaglandin-Endoperoxide Synthases; Sheep; Skin Temperature; Thromboxane B2

1998
Pharmacokinetic studies of flunixin meglumine and phenylbutazone in plasma, exudate and transudate in sheep.
    Journal of veterinary pharmacology and therapeutics, 1998, Volume: 21, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Carrageenan; Clonixin; Cross-Over Studies; Exudates and Transudates; Half-Life; Inflammation; Injections, Intravenous; Male; Oxyphenbutazone; Phenylbutazone; Sheep

1998
In vitro effects of nonsteroidal anti-inflammatory agents and prostaglandins I2, E2, and F2alpha on contractility of taenia of the large colon of horses.
    American journal of veterinary research, 1999, Volume: 60, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Clonixin; Colon; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Epoprostenol; Horses; Indomethacin; Ketoprofen; Muscle Contraction; Muscle, Smooth; Phenylbutazone; Prostaglandins

1999
Effects of anti-inflammatory drugs on lipopolysaccharide-challenged and -unchallenged equine synovial explants.
    American journal of veterinary research, 2001, Volume: 62, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Carbazoles; Clonixin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Horses; Hyaluronic Acid; Isoenzymes; Ketoprofen; Lipopolysaccharides; Meloxicam; Methylprednisolone; Organ Culture Techniques; Phenylbutazone; Prostaglandin-Endoperoxide Synthases; Synovial Membrane; Thiazines; Thiazoles

2001
In vitro effects of cyclooxygenase inhibitors in whole blood of horses, dogs, and cats.
    American journal of veterinary research, 2001, Volume: 62, Issue:11

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Cats; Clonixin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dogs; Female; Furans; Horses; Inhibitory Concentration 50; Isoenzymes; Male; Phenylbutazone; Prostaglandin-Endoperoxide Synthases; Thromboxane B2

2001
Evaluation of the ability of carprofen and flunixin meglumine to inhibit activation of nuclear factor kappa B.
    American journal of veterinary research, 2003, Volume: 64, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Cell Line; Clonixin; Cyclooxygenase Inhibitors; Enzyme Induction; Inflammation; Inhibitory Concentration 50; Lipopolysaccharides; Macrophages; Mice; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phenylbutazone; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Sheep

2003
Use of force plate analysis to compare the analgesic effects of intravenous administration of phenylbutazone and flunixin meglumine in horses with navicular syndrome.
    American journal of veterinary research, 2005, Volume: 66, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Clonixin; Foot Diseases; Horse Diseases; Horses; Injections, Intravenous; Lameness, Animal; Phenylbutazone; Syndrome; Treatment Outcome

2005
Postpartum hemoperitoneum and septic peritonitis in a Thoroughbred mare.
    The Veterinary clinics of North America. Equine practice, 2006, Volume: 22, Issue:1

    Topics: Abdominal Cavity; Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Clonixin; Female; Hemoperitoneum; Horse Diseases; Horses; Metronidazole; Penicillin G Procaine; Peritonitis; Phenylbutazone; Postpartum Period; Serratia Infections; Serratia liquefaciens; Streptococcal Infections; Streptococcus; Treatment Outcome; Ultrasonography; Uterine Rupture

2006
Extralabel use of nonsteroidal anti-inflammatory drugs in cattle.
    Journal of the American Veterinary Medical Association, 2008, Mar-01, Volume: 232, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cattle; Clonixin; Dipyrone; Drug Approval; Drug Residues; Drug Utilization; Food Contamination; Ketoprofen; Meat; Meloxicam; Phenylbutazone; Thiazines; Thiazoles; United States; United States Food and Drug Administration

2008
Evaluation of the brain, renal, and hepatic effects of flunixin meglumine, ketoprofen, and phenylbutazone administration in Iranian fat-tailed sheep.
    Tropical animal health and production, 2011, Volume: 43, Issue:7

    Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Chemical Analysis; Brain; Clonixin; Female; Iran; Ketoprofen; Kidney; Liver; Phenylbutazone; Sheep, Domestic; Urinalysis; Veterinary Drugs

2011
Phenylbutazone and flunixin meglumine used singly or in combination in experimental lameness in horses.
    Equine veterinary journal. Supplement, 2011, Issue:40

    Topics: Animals; Clonixin; Cross-Over Studies; Drug Therapy, Combination; Female; Foot Diseases; Heart Rate; Horse Diseases; Horses; Lameness, Animal; Male; Pain; Phenylbutazone; Time Factors

2011
Anesthesia case of the month. EPAM.
    Journal of the American Veterinary Medical Association, 2012, Jan-01, Volume: 240, Issue:1

    Topics: Analgesics; Anesthesia, General; Anesthetics, General; Animals; Anti-Inflammatory Agents; Clonixin; Female; Horse Diseases; Horses; Male; Muscular Diseases; Phenylbutazone; Postoperative Complications

2012
Identification and characterization of the enzymes responsible for the metabolism of the non-steroidal anti-inflammatory drugs, flunixin meglumine and phenylbutazone, in horses.
    Journal of veterinary pharmacology and therapeutics, 2021, Volume: 44, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Clonixin; Cytochrome P-450 Enzyme System; DNA, Complementary; Gene Expression Regulation, Enzymologic; Horses; Microsomes, Liver; Molecular Structure; Phenylbutazone

2021