phenylalanylproline has been researched along with prolylarginine* in 1 studies
1 other study(ies) available for phenylalanylproline and prolylarginine
| Article | Year |
|---|---|
A new non-natural arginine-like amino acid derivative with a sulfamoyl group in the side-chain.
Sulfamoylation of the L-ornithine methyl ester side-chain generates a non-natural arginine isostere which can be coupled with N-Fmoc-L-proline to synthesize analogues which maintain the structural characteristics of the biologically important Pro-Arg dipeptide sequence. As a probe of its biological importance, the sulfamoylated amino acid derivative was also incorporated as P1 residue in tripeptide structures matching the C-terminal subsequence of fibrinogen. The reported results demonstrate that the functionalization of L-ornithine side-chain with a neutral sulfamoyl group can generate an arginine bioisostere which can be used for the synthesis of prototypes of a new class of human thrombin inhibitors. Topics: Anticoagulants; Arginine; Dipeptides; Drug Design; Humans; Hydrogen Bonding; Oligopeptides; Ornithine; Partial Thromboplastin Time; Sulfonamides; Thrombin; Thrombin Time | 2010 |