Page last updated: 2024-09-03

phenylalanyl-prolyl-arginine-chloromethyl ketone and n(alpha)-(2-naphthylsulfonylglycyl)-4-amidinophenylalanine piperidide

phenylalanyl-prolyl-arginine-chloromethyl ketone has been researched along with n(alpha)-(2-naphthylsulfonylglycyl)-4-amidinophenylalanine piperidide in 3 studies

Compound Research Comparison

Studies
(phenylalanyl-prolyl-arginine-chloromethyl ketone)
Trials
(phenylalanyl-prolyl-arginine-chloromethyl ketone)
Recent Studies (post-2010)
(phenylalanyl-prolyl-arginine-chloromethyl ketone)
Studies
(n(alpha)-(2-naphthylsulfonylglycyl)-4-amidinophenylalanine piperidide)
Trials
(n(alpha)-(2-naphthylsulfonylglycyl)-4-amidinophenylalanine piperidide)
Recent Studies (post-2010) (n(alpha)-(2-naphthylsulfonylglycyl)-4-amidinophenylalanine piperidide)
1914235202

Protein Interaction Comparison

ProteinTaxonomyphenylalanyl-prolyl-arginine-chloromethyl ketone (IC50)n(alpha)-(2-naphthylsulfonylglycyl)-4-amidinophenylalanine piperidide (IC50)
ProthrombinHomo sapiens (human)0.69
Trypsin-1Homo sapiens (human)0.169
Trypsin-2Homo sapiens (human)0.169
Trypsin-3Homo sapiens (human)0.169

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (66.67)18.2507
2000's1 (33.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Banner, DW; Hadváry, P1
Grootenhuis, PD; Karplus, M1
Manallack, DT1

Other Studies

3 other study(ies) available for phenylalanyl-prolyl-arginine-chloromethyl ketone and n(alpha)-(2-naphthylsulfonylglycyl)-4-amidinophenylalanine piperidide

ArticleYear
Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors.
    The Journal of biological chemistry, 1991, Oct-25, Volume: 266, Issue:30

    Topics: Amino Acid Chloromethyl Ketones; Antithrombins; Arginine; Benzamidines; Binding Sites; Dipeptides; Humans; Models, Molecular; Pipecolic Acids; Piperidines; Stereoisomerism; Sulfonamides; Thrombin; Trypsin

1991
Functionality map analysis of the active site cleft of human thrombin.
    Journal of computer-aided molecular design, 1996, Volume: 10, Issue:1

    Topics: Amino Acid Chloromethyl Ketones; Amino Acid Sequence; Arginine; Binding Sites; Dipeptides; Humans; Models, Molecular; Molecular Probes; Molecular Sequence Data; Molecular Structure; Pipecolic Acids; Piperidines; Protein Conformation; Serine Proteinase Inhibitors; Software; Sulfonamides; Thrombin

1996
The use of local surface properties for molecular superimposition.
    Journal of molecular modeling, 2008, Volume: 14, Issue:9

    Topics: Amino Acid Chloromethyl Ketones; Anti-HIV Agents; Anticoagulants; Antimetabolites, Antineoplastic; Crystallography, X-Ray; Dipeptides; Folic Acid; HIV Protease Inhibitors; Humans; Imidazoles; Ligands; Methotrexate; Models, Molecular; Molecular Structure; Piperidines; Protein Binding; Proteins; Quinoxalines; Reverse Transcriptase Inhibitors; Software; Static Electricity; Structure-Activity Relationship; Sulfur Compounds; Surface Properties; Tetrahydrofolate Dehydrogenase

2008