Compounds > phenylalanyl-prolyl-arginine-chloromethyl ketone

Page last updated: 2024-09-03

phenylalanyl-prolyl-arginine-chloromethyl ketone and n(alpha)-(2-naphthylsulfonylglycyl)-4-amidinophenylalanine piperidide

phenylalanyl-prolyl-arginine-chloromethyl ketone has been researched along with n(alpha)-(2-naphthylsulfonylglycyl)-4-amidinophenylalanine piperidide in 3 studies

Compound Research Comparison

Studies (phenylalanyl-prolyl-arginine-chloromethyl ketone)	Trials (phenylalanyl-prolyl-arginine-chloromethyl ketone)	Recent Studies (post-2010) (phenylalanyl-prolyl-arginine-chloromethyl ketone)	Studies (n(alpha)-(2-naphthylsulfonylglycyl)-4-amidinophenylalanine piperidide)	Trials (n(alpha)-(2-naphthylsulfonylglycyl)-4-amidinophenylalanine piperidide)	Recent Studies (post-2010) (n(alpha)-(2-naphthylsulfonylglycyl)-4-amidinophenylalanine piperidide)
191	4	23	52	0	2

Protein Interaction Comparison

Protein	Taxonomy	phenylalanyl-prolyl-arginine-chloromethyl ketone (IC50)	n(alpha)-(2-naphthylsulfonylglycyl)-4-amidinophenylalanine piperidide (IC50)
Prothrombin	Homo sapiens (human)		0.69
Trypsin-1	Homo sapiens (human)		0.169
Trypsin-2	Homo sapiens (human)		0.169
Trypsin-3	Homo sapiens (human)		0.169

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (66.67)	18.2507
2000's	1 (33.33)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Banner, DW; Hadváry, P	1
Grootenhuis, PD; Karplus, M	1
Manallack, DT	1

Other Studies

3 other study(ies) available for phenylalanyl-prolyl-arginine-chloromethyl ketone and n(alpha)-(2-naphthylsulfonylglycyl)-4-amidinophenylalanine piperidide

Article	Year
Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors. The Journal of biological chemistry, 1991, Oct-25, Volume: 266, Issue:30 Topics: Amino Acid Chloromethyl Ketones; Antithrombins; Arginine; Benzamidines; Binding Sites; Dipeptides; Humans; Models, Molecular; Pipecolic Acids; Piperidines; Stereoisomerism; Sulfonamides; Thrombin; Trypsin	1991
Functionality map analysis of the active site cleft of human thrombin. Journal of computer-aided molecular design, 1996, Volume: 10, Issue:1 Topics: Amino Acid Chloromethyl Ketones; Amino Acid Sequence; Arginine; Binding Sites; Dipeptides; Humans; Models, Molecular; Molecular Probes; Molecular Sequence Data; Molecular Structure; Pipecolic Acids; Piperidines; Protein Conformation; Serine Proteinase Inhibitors; Software; Sulfonamides; Thrombin	1996
The use of local surface properties for molecular superimposition. Journal of molecular modeling, 2008, Volume: 14, Issue:9 Topics: Amino Acid Chloromethyl Ketones; Anti-HIV Agents; Anticoagulants; Antimetabolites, Antineoplastic; Crystallography, X-Ray; Dipeptides; Folic Acid; HIV Protease Inhibitors; Humans; Imidazoles; Ligands; Methotrexate; Models, Molecular; Molecular Structure; Piperidines; Protein Binding; Proteins; Quinoxalines; Reverse Transcriptase Inhibitors; Software; Static Electricity; Structure-Activity Relationship; Sulfur Compounds; Surface Properties; Tetrahydrofolate Dehydrogenase	2008