phenylalanyl-prolyl-arginine-chloromethyl ketone has been researched along with mci 9038 in 8 studies
| Studies (phenylalanyl-prolyl-arginine-chloromethyl ketone) | Trials (phenylalanyl-prolyl-arginine-chloromethyl ketone) | Recent Studies (post-2010) (phenylalanyl-prolyl-arginine-chloromethyl ketone) | Studies (mci 9038) | Trials (mci 9038) | Recent Studies (post-2010) (mci 9038) |
|---|---|---|---|---|---|
| 191 | 4 | 23 | 1,087 | 83 | 349 |
| Protein | Taxonomy | phenylalanyl-prolyl-arginine-chloromethyl ketone (IC50) | mci 9038 (IC50) |
|---|---|---|---|
| Prothrombin | Homo sapiens (human) | 0.22 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (75.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Loscalzo, J; Scharfstein, J | 1 |
| Banner, DW; Hadváry, P | 1 |
| Matsuoka, A; Sasaki, Y; Yamamoto, J; Yamashita, T | 1 |
| Grootenhuis, PD; Karplus, M | 1 |
| Drobot, D; Harding, SR; Lyon, AW; Lyon, ME | 1 |
| Deinum, J; Elg, M; Gustafsson, D | 1 |
| Bode, C; Darius, H; Diehm, C; Encke, A; Gulba, DC; Haas, S; Hacke, W; Puhl, W; Quante, M; Riess, H; Scharf, R; Schellong, S; Schrör, T; Schulte, KL; Tebbe, U; Van Aken, H | 1 |
| Hayashi, Y; Taguchi, A; Takayama, K; Yakushiji, F | 1 |
2 review(s) available for phenylalanyl-prolyl-arginine-chloromethyl ketone and mci 9038
| Article | Year |
|---|---|
Molecular approaches to antithrombotic therapy.
Topics: Amino Acid Chloromethyl Ketones; Antithrombins; Arginine; Heparin; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Protease Inhibitors; Sulfonamides; Thrombin; Warfarin | 1992 |
Anticoagulation: the present and future.
Topics: Administration, Oral; Amino Acid Chloromethyl Ketones; Anticoagulants; Arginine; Azetidines; Benzylamines; Binding Sites; Biological Availability; Blood Coagulation; Comorbidity; Coumarins; Drug Design; Embolism; Female; Forecasting; Glycine; Guanidines; Heart Diseases; Hemorrhage; Heparin; Heparin, Low-Molecular-Weight; Hirudin Therapy; Humans; Neoplasms; Pipecolic Acids; Pregnancy; Pregnancy Complications, Hematologic; Prodrugs; Safety; Serine; Stroke; Sulfonamides; Thrombin; Thrombophilia; Thrombosis | 2001 |
6 other study(ies) available for phenylalanyl-prolyl-arginine-chloromethyl ketone and mci 9038
| Article | Year |
|---|---|
Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors.
Topics: Amino Acid Chloromethyl Ketones; Antithrombins; Arginine; Benzamidines; Binding Sites; Dipeptides; Humans; Models, Molecular; Pipecolic Acids; Piperidines; Stereoisomerism; Sulfonamides; Thrombin; Trypsin | 1991 |
The antithrombotic effect of low molecular weight synthetic thrombin inhibitors, argatroban and PPACK, on He-Ne laser-induced thrombosis in rat mesenteric microvessels.
Topics: Amino Acid Chloromethyl Ketones; Animals; Antithrombins; Arginine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Male; Mesentery; Microcirculation; Pipecolic Acids; Platelet Aggregation; Rats; Rats, Wistar; Sulfonamides; Thrombin; Thrombosis | 1993 |
Functionality map analysis of the active site cleft of human thrombin.
Topics: Amino Acid Chloromethyl Ketones; Amino Acid Sequence; Arginine; Binding Sites; Dipeptides; Humans; Models, Molecular; Molecular Probes; Molecular Sequence Data; Molecular Structure; Pipecolic Acids; Piperidines; Protein Conformation; Serine Proteinase Inhibitors; Software; Sulfonamides; Thrombin | 1996 |
Use of thrombin inhibitors ex vivo allows critical care clinical chemistry and hematology testing on common specimens.
Topics: Amino Acid Chloromethyl Ketones; Antithrombins; Arginine; Blood Chemical Analysis; Blood Preservation; Blood Specimen Collection; Critical Care; Humans; Pipecolic Acids; Sulfonamides | 1997 |
The importance of enzyme inhibition kinetics for the effect of thrombin inhibitors in a rat model of arterial thrombosis.
Topics: Amino Acid Chloromethyl Ketones; Animals; Anticoagulants; Arginine; Azetidines; Benzylamines; Carotid Artery Thrombosis; Dose-Response Relationship, Drug; Fibrinolytic Agents; Glycine; Hemodynamics; Heparin; Hirudin Therapy; Hirudins; Kinetics; Male; Oligopeptides; Partial Thromboplastin Time; Peptide Fragments; Pipecolic Acids; Piperidines; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sulfonamides; Thrombin; Thrombin Time | 1997 |
Identification of a degrading enzyme in human serum that hydrolyzes a C-terminal core sequence of neuromedin U.
Topics: Amino Acid Chloromethyl Ketones; Arginine; Humans; Hydrolysis; Neuropeptides; Pipecolic Acids; Serum; Sulfonamides; Thrombin | 2016 |