phenylalanyl-prolyl-arginine-chloromethyl ketone has been researched along with hirudin in 33 studies
| Studies (phenylalanyl-prolyl-arginine-chloromethyl ketone) | Trials (phenylalanyl-prolyl-arginine-chloromethyl ketone) | Recent Studies (post-2010) (phenylalanyl-prolyl-arginine-chloromethyl ketone) | Studies (hirudin) | Trials (hirudin) | Recent Studies (post-2010) (hirudin) |
|---|---|---|---|---|---|
| 191 | 4 | 23 | 21 | 0 | 2 |
| 191 | 4 | 23 | 3,658 | 378 | 995 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (12.12) | 18.7374 |
| 1990's | 23 (69.70) | 18.2507 |
| 2000's | 3 (9.09) | 29.6817 |
| 2010's | 2 (6.06) | 24.3611 |
| 2020's | 1 (3.03) | 2.80 |
| Authors | Studies |
|---|---|
| Malovichko, MV; Maurer, MC; Sabo, TM | 1 |
| Loscalzo, J; Scharfstein, J | 1 |
| Church, FC; Pratt, CW; Rogers, SJ; Whinna, HC | 1 |
| Kaminski, M; Mosesson, MW; Siebenlist, KR | 1 |
| Agnelli, G; Cosmi, B; Nenci, GG; Pascucci, C | 1 |
| Kaminski, M; Mosesson, MW | 1 |
| Hirsh, J; Hudoba, M; Maraganore, J; Massel, D; Weitz, JI | 1 |
| Fenton, JW; Harpel, PC | 1 |
| Kinlough-Rathbone, RL; Lalau Keraly, C; Mustard, JF; Packham, MA; Suzuki, H | 1 |
| Kaminski, M; McDonagh, J | 1 |
| Robertson, JT; Shirasawa, Y; White, RP | 1 |
| Baird, JL; Raper, JA | 1 |
| Black, CM; Cambrey, AD; Chambers, RC; duBois, RM; Gray, AJ; Harrison, NK; Hernández-Rodríguez, NA; McAnulty, RJ; Scully, MF; Southcott, AM | 1 |
| Mann, KG; Padmanabhan, KP; Tulinsky, A; Vijayalakshmi, J | 1 |
| Cicala, C; Emerson, M; Liu, JT; Page, CP; Paul, W | 1 |
| Connolly, TM; Gan, ZR; Lewis, SD; Li, Y; Sardana, MK; Shafer, JA; Tsai, PK | 1 |
| Chrusciel, RA; Kahn, M; Nakanishi, H; Priebe, C; Shen, R; Tulinsky, A; Wu, TP; Yee, V | 1 |
| Brash, JL; Kinlough-Rathbone, RL; Rubens, FD; Weitz, JI | 1 |
| Benzakour, O; Dennehy, U; Kakkar, VV; Kanthou, C | 1 |
| Fenton, JW | 1 |
| Abendschein, DR; Eisenberg, PR; Oltrona, L; Rubin, BG | 1 |
| Macey, MG; McCarthy, DA | 1 |
| Ammar, T; Coller, BS; Scudder, LE | 1 |
| Prasa, D; Stürzebecher, J; Svendsen, L | 1 |
| Aleksic, I; Althaus, U; Gafner, V; Joch, H; Julmy, F; Lüscher, TF; Noll, G; Rabelink, TJ; Ruschitzka, F; Yang, Z | 1 |
| Deinum, J; Elg, M; Gustafsson, D | 1 |
| Chen, D; Dorling, A; George, AJ; Kemball-Cook, G; Lechler, RI; McVey, JH; Riesbeck, K; Tuddenham, EG | 1 |
| Akiba, S; Kawauchi, T; Sato, T | 1 |
| Berry, CN; Gandossi, E; Lunven, C | 1 |
| Frebelius, S; Grip, L; Linder, R; Swedenborg, J | 1 |
| Brynda, E; Dyr, JE; Houska, M; Riedel, T | 1 |
| Alegret, M; Laguna, JC; Merlos, M; Piera, L; Pou, J; Rebollo, A; Roglans, N | 1 |
| Grabau, R; Palekar, R; Pan, H; Vargas, I; Wickline, SA; Wilson, AJ; Zhou, Q | 1 |
2 review(s) available for phenylalanyl-prolyl-arginine-chloromethyl ketone and hirudin
| Article | Year |
|---|---|
Molecular approaches to antithrombotic therapy.
Topics: Amino Acid Chloromethyl Ketones; Antithrombins; Arginine; Heparin; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Protease Inhibitors; Sulfonamides; Thrombin; Warfarin | 1992 |
Thrombin functions and antithrombotic intervention.
Topics: Amino Acid Chloromethyl Ketones; Amino Acid Sequence; Animals; Antithrombins; Blood Coagulation; Cricetinae; Hirudin Therapy; Hirudins; Mice; Models, Molecular; Molecular Sequence Data; Peptide Fragments; Rats; Receptors, Thrombin; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Species Specificity; Substrate Specificity; Thrombin; Thrombosis | 1995 |
31 other study(ies) available for phenylalanyl-prolyl-arginine-chloromethyl ketone and hirudin
| Article | Year |
|---|---|
Ligand binding to anion-binding exosites regulates conformational properties of thrombin.
Topics: Amino Acid Chloromethyl Ketones; Animals; Anions; Binding Sites; Catalytic Domain; Cattle; Deuterium Exchange Measurement; Fibrinogen; Hirudins; Ligands; Membrane Glycoproteins; Models, Molecular; Peptide Fragments; Platelet Glycoprotein GPIb-IX Complex; Protein Binding; Receptors, Thrombin; Thrombin | 2013 |
Role of thrombin exosites in inhibition by heparin cofactor II.
Topics: Amino Acid Chloromethyl Ketones; Amino Acid Sequence; Animals; Antithrombins; Binding Sites; Cattle; Glycosaminoglycans; Heparin Cofactor II; Hirudins; Humans; Molecular Sequence Data; Peptide Fragments; Protein Conformation; Thrombin | 1992 |
Evidence for thrombin enhancement of fibrin polymerization that is independent of its catalytic activity.
Topics: Amino Acid Chloromethyl Ketones; Blood Coagulation; Chromatography, High Pressure Liquid; Fibrin; Fibrinogen; Hirudins; Humans; Polymers; Thrombin | 1991 |
Effects of therapeutic doses of heparin on thrombolysis with tissue-type plasminogen activator in rabbits.
Topics: Amino Acid Chloromethyl Ketones; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Factor Xa; Fibrin; Heparin; Hirudins; Rabbits; Recombinant Proteins; Thrombolytic Therapy; Thrombosis; Tissue Plasminogen Activator | 1990 |
The acceleratory effect of thrombin on fibrin clot assembly.
Topics: Amino Acid Chloromethyl Ketones; Blood Coagulation; Fibrin; Fibrinogen; Hirudins; Kinetics; Nephelometry and Turbidimetry; Polymers; Thrombin | 1990 |
Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors.
Topics: Amino Acid Chloromethyl Ketones; Antithrombin III; Blood Coagulation; Fibrin; Fibrinopeptide A; Heparin; Hirudins; Humans; In Vitro Techniques; Kinetics; Peptide Fragments; Protease Inhibitors; Protein Binding; Solubility; Thrombin | 1990 |
Novel immunoenzyme assays for thrombin-antithrombin III and thrombin-alpha 2-macroglobulin complexes in plasma.
Topics: alpha-Macroglobulins; Amino Acid Chloromethyl Ketones; Antithrombins; Blood Coagulation; Enzyme-Linked Immunosorbent Assay; Hirudins; Humans; Immunoassay; Immunosorbent Techniques; Kinetics; Macromolecular Substances; Thrombin | 1986 |
Conditions affecting the responses of human platelets to epinephrine.
Topics: Adenosine Diphosphate; Amino Acid Chloromethyl Ketones; Antithrombins; Blood Platelets; Calcium; Drug Synergism; Epinephrine; Hirudins; Humans; Microscopy, Electron, Scanning; Platelet Aggregation | 1988 |
Inhibited thrombins. Interactions with fibrinogen and fibrin.
Topics: Amino Acid Chloromethyl Ketones; Arginine; Binding Sites; Chromatography, Affinity; Dansyl Compounds; Dipeptides; Fibrin; Fibrinogen; Fluorescent Dyes; Hirudins; Phenylmethylsulfonyl Fluoride; Protein Binding; Pyridoxal Phosphate; Thrombin | 1987 |
Comparison of responses elicited by alpha-thrombin in isolated canine basilar, coronary, mesenteric, and renal arteries.
Topics: Amino Acid Chloromethyl Ketones; Animals; Basilar Artery; Coronary Vessels; Dogs; Female; Heparin; Hirudins; Hot Temperature; Male; Mesenteric Arteries; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Renal Artery; Thrombin | 1984 |
A serine proteinase involved in contact mediated repulsion of retinal growth cones by DRG neurites.
Topics: Adrenal Glands; Amino Acid Chloromethyl Ketones; Animals; Cattle; Cell Communication; Central Nervous System; Chick Embryo; Ganglia, Spinal; Hirudins; Membranes; Mice; Neurites; Retina; Serine Endopeptidases; Serine Proteinase Inhibitors; Thrombin; Tissue Extracts | 1995 |
Role of thrombin in pulmonary fibrosis.
Topics: Alveolitis, Extrinsic Allergic; Amino Acid Chloromethyl Ketones; Antithrombins; Bronchoalveolar Lavage Fluid; Cell Division; Fibroblasts; Hirudins; Humans; Pulmonary Fibrosis; Sarcoidosis; Thrombin | 1995 |
The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin.
Topics: Amino Acid Chloromethyl Ketones; Amino Acid Sequence; Binding Sites; Crystallography, X-Ray; Enzyme Activation; Enzyme Precursors; Hirudins; Humans; Hydrogen Bonding; Models, Molecular; Molecular Sequence Data; Peptide Fragments; Protein Binding; Protein Conformation; Prothrombin; Thrombin | 1994 |
Thrombin inhibitors and anti-coagulants on thrombin-induced embolisation in rabbit cranial vasculature.
Topics: Amino Acid Chloromethyl Ketones; Animals; Anticoagulants; Antithrombins; Blood Platelets; Boron Compounds; Dalteparin; Dose-Response Relationship, Drug; Fibrinolytic Agents; Heparin; Hirudin Therapy; Hirudins; Indium; Infusions, Intra-Arterial; Intracranial Embolism and Thrombosis; Isotope Labeling; Male; Molecular Weight; Oligopeptides; Peptide Fragments; Platelet Aggregation; Platelet Aggregation Inhibitors; Pulmonary Circulation; Rabbits; Recombinant Proteins; Structure-Activity Relationship; Thrombin | 1994 |
Importance of the Arg-Gly-Asp triplet in human thrombin for maintenance of structure and function.
Topics: Amino Acid Chloromethyl Ketones; Amino Acid Sequence; Base Sequence; Catalysis; Circular Dichroism; Disulfides; Dose-Response Relationship, Drug; Fibrinogen; Hirudins; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligopeptides; Platelet Activation; Protein C; Protein Conformation; Receptors, Cell Surface; Receptors, Thrombin; Recombinant Proteins; Serotonin; Structure-Activity Relationship; Thrombin | 1993 |
The structure of a designed peptidomimetic inhibitor complex of alpha-thrombin.
Topics: Amino Acid Chloromethyl Ketones; Azepines; Fibrinogen; Hirudins; Models, Molecular; Molecular Conformation; Oligopeptides; Peptide Fragments; Protein Conformation; Serine Proteinase Inhibitors; Substrate Specificity; Thrombin; X-Ray Diffraction | 1993 |
The effect of antithrombin III-independent thrombin inhibitors and heparin on fibrin accretion onto fibrin-coated polyethylene.
Topics: Amino Acid Chloromethyl Ketones; Amino Acid Sequence; Antithrombin III; Blood Vessel Prosthesis; Fibrin; Heparin; Hirudins; Humans; In Vitro Techniques; Microscopy, Electron, Scanning; Molecular Sequence Data; Peptide Fragments; Polyethylenes; Recombinant Proteins; Surface Properties; Thrombin; Thrombosis | 1993 |
Structural domains of thrombin involved in the induction of mitogenesis in cultured human vascular smooth muscle cells.
Topics: Amino Acid Chloromethyl Ketones; Amino Acid Sequence; Antithrombin III; Antithrombins; Binding Sites; Cells, Cultured; DNA; Hirudins; Humans; Kinetics; Mitogens; Molecular Sequence Data; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-fos; Structure-Activity Relationship; Thrombin | 1995 |
Efficacy of local inhibition of procoagulant activity associated with small-diameter prosthetic vascular grafts.
Topics: Amino Acid Chloromethyl Ketones; Arthropod Proteins; Blood Coagulation; Blood Vessel Prosthesis; Factor Xa Inhibitors; Fibrin; Fibrinolytic Agents; Fibrinopeptide A; Hirudins; Humans; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Lipoproteins; Peptides; Thrombin | 1996 |
Novel anticoagulants for flow cytometric analysis of live leucocytes in whole blood.
Topics: Adult; Amino Acid Chloromethyl Ketones; Anticoagulants; Aprotinin; Blood; Blood Cell Count; Citrates; Flow Cytometry; Hirudins; Humans; L-Selectin; Leukocytes; Leukocytes, Mononuclear; Leupeptins; Macrophage-1 Antigen; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phenylmethylsulfonyl Fluoride; Sulfones | 1996 |
In vitro effects of the platelet glycoprotein IIb/IIIa receptor antagonist c7E3 Fab on the activated clotting time.
Topics: Abciximab; Adult; Amino Acid Chloromethyl Ketones; Animals; Antibodies, Monoclonal; Antithrombins; Cattle; Female; Heparin; Hirudins; Humans; Immunoglobulin Fab Fragments; Intestines; Lung; Male; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIb-IX Complex; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Swine; Whole Blood Coagulation Time | 1997 |
The ability of thrombin inhibitors to reduce the thrombin activity generated in plasma on extrinsic and intrinsic activation.
Topics: Amino Acid Chloromethyl Ketones; Antithrombins; Binding Sites; Blood Coagulation; Blood Coagulation Tests; Hirudins; Humans; Kinetics; Peptide Fragments; Recombinant Proteins; Sulfones; Thrombin | 1997 |
Different effects of thrombin receptor activation on endothelium and smooth muscle cells of human coronary bypass vessels. Implications for venous bypass graft failure.
Topics: Amino Acid Chloromethyl Ketones; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Coronary Artery Bypass; DNA Replication; Endothelium, Vascular; Enzyme Activation; Hirudin Therapy; Hirudins; Humans; Internal Mammary-Coronary Artery Anastomosis; Mitogen-Activated Protein Kinase 1; Muscle, Smooth, Vascular; Oligopeptides; Peptide Fragments; Phosphorylation; Prosthesis Failure; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Receptors, Thrombin; Saphenous Vein; Thrombin; Up-Regulation; Vasoconstriction | 1997 |
The importance of enzyme inhibition kinetics for the effect of thrombin inhibitors in a rat model of arterial thrombosis.
Topics: Amino Acid Chloromethyl Ketones; Animals; Anticoagulants; Arginine; Azetidines; Benzylamines; Carotid Artery Thrombosis; Dose-Response Relationship, Drug; Fibrinolytic Agents; Glycine; Hemodynamics; Heparin; Hirudin Therapy; Hirudins; Kinetics; Male; Oligopeptides; Partial Thromboplastin Time; Peptide Fragments; Pipecolic Acids; Piperidines; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sulfonamides; Thrombin; Thrombin Time | 1997 |
Expression of hirudin fusion proteins in mammalian cells: a strategy for prevention of intravascular thrombosis.
Topics: Amino Acid Chloromethyl Ketones; Animals; Antithrombins; Blood Coagulation; Catalytic Domain; CD4 Antigens; Cell Line; Cytoplasmic Granules; Hirudins; Histocompatibility Antigens Class I; Humans; Membrane Proteins; P-Selectin; Protein Sorting Signals; Protein Structure, Tertiary; Recombinant Fusion Proteins; Thrombin; Thrombosis; Transfection | 1998 |
Acceleration of Ca2+ ionophore-induced arachidonic acid liberation by thrombin without the proteolytic action toward the receptor in human platelets.
Topics: Amino Acid Chloromethyl Ketones; Antithrombins; Arachidonic Acid; Blood Platelets; Calcium; Enzyme Activation; Hirudins; Humans; Ionomycin; Ionophores; Leukocyte Elastase; Leupeptins; Peptide Fragments; Phospholipases A; Phospholipases A2; Platelet Glycoprotein GPIb-IX Complex; Receptor, PAR-1; Receptors, Thrombin; Thrombin; Trypsin | 1999 |
Role of clot-associated (-derived) thrombin in cell proliferation induced by fibrin clots in vitro.
Topics: Amino Acid Chloromethyl Ketones; Animals; Anticoagulants; Antithrombin III; Antithrombins; Blood Coagulation; Cell Division; Cell Line; Cricetinae; Cricetulus; Fibrin; Fibroblasts; Heparin; Hirudins; Male; Rabbits; Recombinant Proteins; Serine Proteinase Inhibitors; Thrombin | 2000 |
The influence of direct and antithrombin-dependent thrombin inhibitors on the procoagulant and anticoagulant effects of thrombin.
Topics: Amino Acid Chloromethyl Ketones; Anticoagulants; Azetidines; Benzylamines; Clinical Trials as Topic; Coagulants; Coronary Artery Disease; Fibrinopeptide A; Glycine; Hirudins; Humans; Peptide Fragments; Piperidines; Protein C; Thrombin | 2003 |
Controlled preparation of thin fibrin films immobilized at solid surfaces.
Topics: Amino Acid Chloromethyl Ketones; Animals; Biocompatible Materials; Fibrin; Fibrinogen; Fibrinolytic Agents; Hirudins; Humans; Materials Testing; Methylmethacrylates; Polyhydroxyethyl Methacrylate; Porosity; Protease Inhibitors; Surface Properties; Swine; Thrombin; Tissue Scaffolds | 2009 |
Tissue factor pathway inhibitor 2 is induced by thrombin in human macrophages.
Topics: Amino Acid Chloromethyl Ketones; Anthracenes; Antithrombins; Blotting, Western; Butadienes; Cell Line; Cells, Cultured; Cyclooxygenase 2 Inhibitors; Enzyme Inhibitors; Flavonoids; Gene Expression; Glycoproteins; Hirudins; Humans; JNK Mitogen-Activated Protein Kinases; Lipoproteins, VLDL; Macrophages; Mitogen-Activated Protein Kinases; NF-kappa B; Nitriles; Nitrobenzenes; Reverse Transcriptase Polymerase Chain Reaction; Sesquiterpenes; Signal Transduction; Sulfonamides; Thrombin; Time Factors | 2011 |
Formulation and Characterization of Antithrombin Perfluorocarbon Nanoparticles.
Topics: Amino Acid Chloromethyl Ketones; Antithrombins; Fluorocarbons; Hirudins; Magnetic Iron Oxide Nanoparticles; Nanoparticles; Particle Size; Peptide Fragments; Polyhydroxyethyl Methacrylate; Recombinant Proteins | 2020 |