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phenylalanyl-prolyl-arginine-chloromethyl ketone and fibrin

phenylalanyl-prolyl-arginine-chloromethyl ketone has been researched along with fibrin in 23 studies

Compound Research Comparison

Studies
(phenylalanyl-prolyl-arginine-chloromethyl ketone)
Trials
(phenylalanyl-prolyl-arginine-chloromethyl ketone)
Recent Studies (post-2010)
(phenylalanyl-prolyl-arginine-chloromethyl ketone)
Studies
(fibrin)
Trials
(fibrin)
Recent Studies (post-2010) (fibrin)
19142315,9943283,808

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19904 (17.39)18.7374
1990's14 (60.87)18.2507
2000's4 (17.39)29.6817
2010's1 (4.35)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Broersma, RJ; Heminger, EF; Kutcher, LW1
Kaminski, M; Mosesson, MW; Siebenlist, KR1
Hubbell, JA; Wagner, WR1
Agnelli, G; Cosmi, B; Nenci, GG; Pascucci, C1
Kaminski, M; Mosesson, MW1
Hörmann, H; Jelinić, V; Richter, H1
Hirsh, J; Hudoba, M; Maraganore, J; Massel, D; Weitz, JI1
Briston, C; Carlson, RW; Chilton, SM; Schaeffer, RC1
Kaminski, M; McDonagh, J1
Doellgast, GJ; Rothberger, H1
Carlson, RW; Chilton, SM; Hadden, TJ; Schaeffer, RC1
Maragoudakis, ME; Pipili-Synetos, E; Tsopanoglou, NE1
Bänninger, H; Furlan, M; Lämmle, B1
Brash, JL; Kinlough-Rathbone, RL; Rubens, FD; Weitz, JI1
Bunce, LA; Francis, CW; Hamaguchi, M; Sporn, LA1
Carpen, O; Lassila, R; Siljander, P1
Abendschein, DR; Eisenberg, PR; Oltrona, L; Rubin, BG1
Ellis, V; Razzaq, TM; Werner, F1
Berry, CN; Gandossi, E; Lunven, C1
Bajzar, L; Fredenburgh, JC; Rischke, JA; Stewart, RJ; Weitz, JI1
Brynda, E; Dyr, JE; Houska, M; Riedel, T1
Klegerman, ME; McPherson, DD; Zou, Y1
Canino, J; Canobbio, I; Guidetti, GF; Torti, M; Visconte, C; Zarà, M1

Other Studies

23 other study(ies) available for phenylalanyl-prolyl-arginine-chloromethyl ketone and fibrin

ArticleYear
The effect of thrombin inhibition in a rat arterial thrombosis model.
    Thrombosis research, 1991, Nov-15, Volume: 64, Issue:4

    Topics: Amino Acid Chloromethyl Ketones; Animals; Blood Platelets; Carotid Artery Thrombosis; Disease Models, Animal; Ferrous Compounds; Fibrin; Heparin; Male; Rats; Rats, Inbred Strains; Thrombin; Thrombocytopenia

1991
Evidence for thrombin enhancement of fibrin polymerization that is independent of its catalytic activity.
    The Journal of laboratory and clinical medicine, 1991, Volume: 117, Issue:3

    Topics: Amino Acid Chloromethyl Ketones; Blood Coagulation; Chromatography, High Pressure Liquid; Fibrin; Fibrinogen; Hirudins; Humans; Polymers; Thrombin

1991
Local thrombin synthesis and fibrin formation in an in vitro thrombosis model result in platelet recruitment and thrombus stabilization on collagen in heparinized blood.
    The Journal of laboratory and clinical medicine, 1990, Volume: 116, Issue:5

    Topics: Amino Acid Chloromethyl Ketones; Antibodies; Antithrombins; Blood Platelets; Collagen; Factor X; Fibrin; Humans; Microscopy, Electron, Scanning; Models, Biological; Oligopeptides; Platelet Adhesiveness; Platelet Aggregation; Platelet Count; Prothrombin; Thrombin; Thrombosis

1990
Effects of therapeutic doses of heparin on thrombolysis with tissue-type plasminogen activator in rabbits.
    Blood, 1990, Nov-15, Volume: 76, Issue:10

    Topics: Amino Acid Chloromethyl Ketones; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Factor Xa; Fibrin; Heparin; Hirudins; Rabbits; Recombinant Proteins; Thrombolytic Therapy; Thrombosis; Tissue Plasminogen Activator

1990
The acceleratory effect of thrombin on fibrin clot assembly.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 1990, Volume: 1, Issue:4-5

    Topics: Amino Acid Chloromethyl Ketones; Blood Coagulation; Fibrin; Fibrinogen; Hirudins; Kinetics; Nephelometry and Turbidimetry; Polymers; Thrombin

1990
Cell-binding and internalization of soluble fibrin by platelets.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 1990, Volume: 1, Issue:4-5

    Topics: Amino Acid Chloromethyl Ketones; Amino Acid Sequence; Blood Platelets; Endocytosis; Fibrin; Humans; Molecular Sequence Data; Oligopeptides; Prothrombin; Thrombin

1990
Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors.
    The Journal of clinical investigation, 1990, Volume: 86, Issue:2

    Topics: Amino Acid Chloromethyl Ketones; Antithrombin III; Blood Coagulation; Fibrin; Fibrinopeptide A; Heparin; Hirudins; Humans; In Vitro Techniques; Kinetics; Peptide Fragments; Protease Inhibitors; Protein Binding; Solubility; Thrombin

1990
Disseminated intravascular coagulation following Echis carinatus venom in dogs: effects of a synthetic thrombin inhibitor.
    The Journal of laboratory and clinical medicine, 1986, Volume: 107, Issue:6

    Topics: Amino Acid Chloromethyl Ketones; Animals; Disseminated Intravascular Coagulation; Dogs; Endopeptidases; Factor VIII; Factor XII; Fibrin; Fibrin Fibrinogen Degradation Products; Fibrinogen; Hemoglobins; Kinetics; Leukopenia; Partial Thromboplastin Time; Prothrombin; Thrombocytopenia; Viper Venoms

1986
Inhibited thrombins. Interactions with fibrinogen and fibrin.
    The Biochemical journal, 1987, Mar-15, Volume: 242, Issue:3

    Topics: Amino Acid Chloromethyl Ketones; Arginine; Binding Sites; Chromatography, Affinity; Dansyl Compounds; Dipeptides; Fibrin; Fibrinogen; Fluorescent Dyes; Hirudins; Phenylmethylsulfonyl Fluoride; Protein Binding; Pyridoxal Phosphate; Thrombin

1987
Enzyme-linked coagulation assay: a clot-based, solid-phase assay for thrombin.
    Analytical biochemistry, 1985, Volume: 147, Issue:2

    Topics: Amino Acid Chloromethyl Ketones; Benzamidines; Blood Coagulation; Fibrin; Humans; Methods; Peroxidases; Thrombin

1985
Pulmonary fibrin microembolism with Echis carinatus venom in dogs: effects of a synthetic thrombin inhibitor.
    Journal of applied physiology: respiratory, environmental and exercise physiology, 1984, Volume: 57, Issue:6

    Topics: Amino Acid Chloromethyl Ketones; Animals; Body Water; Disease Models, Animal; Dogs; Fibrin; Fibrinogen; Hemodynamics; Leukocyte Count; Lung; Platelet Count; Pulmonary Embolism; Respiration; Thrombin; Viper Venoms

1984
Thrombin promotes angiogenesis by a mechanism independent of fibrin formation.
    The American journal of physiology, 1993, Volume: 264, Issue:5 Pt 1

    Topics: Allantoin; Amino Acid Chloromethyl Ketones; Animals; Antithrombins; Chick Embryo; Chorion; Collagen; Fibrin; Neovascularization, Pathologic; Thrombin

1993
Binding of alpha-thrombin to fibrin depends on the quality of the fibrin network.
    The Biochemical journal, 1994, Feb-15, Volume: 298 ( Pt 1)

    Topics: Amino Acid Chloromethyl Ketones; Amino Acid Sequence; Batroxobin; Binding Sites; Fibrin; Humans; In Vitro Techniques; Iodine Radioisotopes; Molecular Sequence Data; Thrombin

1994
The effect of antithrombin III-independent thrombin inhibitors and heparin on fibrin accretion onto fibrin-coated polyethylene.
    Thrombosis and haemostasis, 1993, Feb-01, Volume: 69, Issue:2

    Topics: Amino Acid Chloromethyl Ketones; Amino Acid Sequence; Antithrombin III; Blood Vessel Prosthesis; Fibrin; Heparin; Hirudins; Humans; In Vitro Techniques; Microscopy, Electron, Scanning; Molecular Sequence Data; Peptide Fragments; Polyethylenes; Recombinant Proteins; Surface Properties; Thrombin; Thrombosis

1993
Spreading of platelets on fibrin is mediated by the amino terminus of the beta chain including peptide beta 15-42.
    Blood, 1993, May-01, Volume: 81, Issue:9

    Topics: Amino Acid Chloromethyl Ketones; Amino Acid Sequence; Antibodies, Monoclonal; Blood Platelets; Cell Movement; Electrophoresis, Polyacrylamide Gel; Fibrin; Fibrinogen; Fibrinopeptide A; Fibrinopeptide B; Humans; In Vitro Techniques; Molecular Sequence Data; Oligopeptides; Platelet Adhesiveness; Serotonin

1993
Platelet-derived microparticles associate with fibrin during thrombosis.
    Blood, 1996, Jun-01, Volume: 87, Issue:11

    Topics: Amino Acid Chloromethyl Ketones; Amino Acid Sequence; Biomarkers; Blood Coagulation; Blood Platelets; Calcimycin; Calcium; Collagen; Fibrin; Fibrinogen; Humans; Ionophores; Microscopy, Electron, Scanning; Microscopy, Fluorescence; Molecular Sequence Data; Oligopeptides; P-Selectin; Perfusion; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombin; Thrombosis; von Willebrand Factor

1996
Efficacy of local inhibition of procoagulant activity associated with small-diameter prosthetic vascular grafts.
    Journal of vascular surgery, 1996, Volume: 24, Issue:4

    Topics: Amino Acid Chloromethyl Ketones; Arthropod Proteins; Blood Coagulation; Blood Vessel Prosthesis; Factor Xa Inhibitors; Fibrin; Fibrinolytic Agents; Fibrinopeptide A; Hirudins; Humans; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Lipoproteins; Peptides; Thrombin

1996
Tissue plasminogen activator binds to human vascular smooth muscle cells by a novel mechanism. Evidence for a reciprocal linkage between inhibition of catalytic activity and cellular binding.
    The Journal of biological chemistry, 1999, Jul-30, Volume: 274, Issue:31

    Topics: Amino Acid Chloromethyl Ketones; Binding Sites; Binding, Competitive; Catalysis; Cells, Cultured; Circular Dichroism; Fibrin; Humans; Kinetics; Muscle, Smooth, Vascular; Mutagenesis, Site-Directed; Protein Conformation; Recombinant Proteins; Saphenous Vein; Serine Proteinase Inhibitors; Tissue Plasminogen Activator

1999
Role of clot-associated (-derived) thrombin in cell proliferation induced by fibrin clots in vitro.
    British journal of pharmacology, 2000, Volume: 129, Issue:5

    Topics: Amino Acid Chloromethyl Ketones; Animals; Anticoagulants; Antithrombin III; Antithrombins; Blood Coagulation; Cell Division; Cell Line; Cricetinae; Cricetulus; Fibrin; Fibroblasts; Heparin; Hirudins; Male; Rabbits; Recombinant Proteins; Serine Proteinase Inhibitors; Thrombin

2000
Thrombin-activable fibrinolysis inhibitor attenuates (DD)E-mediated stimulation of plasminogen activation by reducing the affinity of (DD)E for tissue plasminogen activator. A potential mechanism for enhancing the fibrin specificity of tissue plasminogen
    The Journal of biological chemistry, 2000, Nov-24, Volume: 275, Issue:47

    Topics: Amino Acid Chloromethyl Ketones; Arginine; Carboxypeptidase B; Carboxypeptidase B2; Carboxypeptidases; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Fibrin; Fibrin Fibrinogen Degradation Products; Fibrinolysin; Humans; Kinetics; Lysine; Models, Chemical; Tissue Plasminogen Activator

2000
Controlled preparation of thin fibrin films immobilized at solid surfaces.
    Journal of biomedical materials research. Part A, 2009, Volume: 88, Issue:2

    Topics: Amino Acid Chloromethyl Ketones; Animals; Biocompatible Materials; Fibrin; Fibrinogen; Fibrinolytic Agents; Hirudins; Humans; Materials Testing; Methylmethacrylates; Polyhydroxyethyl Methacrylate; Porosity; Protease Inhibitors; Surface Properties; Swine; Thrombin; Tissue Scaffolds

2009
Fibrin targeting of echogenic liposomes with inactivated tissue plasminogen activator.
    Journal of liposome research, 2008, Volume: 18, Issue:2

    Topics: Amino Acid Chloromethyl Ketones; Animals; Antibodies; Antibody Affinity; Atherosclerosis; Contrast Media; Drug Delivery Systems; Enzyme Activation; Fibrin; Fibrinolytic Agents; Humans; Liposomes; Serine Proteinase Inhibitors; Tissue Plasminogen Activator; Ultrasonography

2008
Molecular mechanisms of platelet activation and aggregation induced by breast cancer cells.
    Cellular signalling, 2018, Volume: 48

    Topics: Amino Acid Chloromethyl Ketones; Aspirin; Blood Platelets; Breast Neoplasms; Caco-2 Cells; Calcium Chloride; Colorectal Neoplasms; Female; Fibrin; Fibrinogen; Humans; Integrin alpha2; MCF-7 Cells; Platelet Activation; Platelet Aggregation; Thromboxane A2; Type C Phospholipases

2018