phenylalanyl-prolyl-arginine-chloromethyl ketone and eptifibatide

phenylalanyl-prolyl-arginine-chloromethyl ketone has been researched along with eptifibatide in 6 studies

Compound Research Comparison

Studies (phenylalanyl-prolyl-arginine-chloromethyl ketone)	Trials (phenylalanyl-prolyl-arginine-chloromethyl ketone)	Recent Studies (post-2010) (phenylalanyl-prolyl-arginine-chloromethyl ketone)	Studies (eptifibatide)	Trials (eptifibatide)	Recent Studies (post-2010) (eptifibatide)
191	4	23	907	220	212

Protein Interaction Comparison

Protein	Taxonomy	phenylalanyl-prolyl-arginine-chloromethyl ketone (IC50)	eptifibatide (IC50)
Integrin beta-3	Homo sapiens (human)		0.226
Integrin alpha-IIb	Homo sapiens (human)		0.226

Research

Studies (6)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	6 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Proimos, G	1
Eisenberg, PR; Gretler, D; Harrington, RA; Jennings, LK; Joseph, DM; Kleiman, NS; Labinaz, M; Lincoff, AM; McDougal, MF; Potthoff, RF; Tardiff, BE; Vorchheimer, DA	1
Califf, RM; Davidson, CJ; Gilchrist, IC; Grines, CL; Jennings, LK; Kitt, MM; Kleiman, NS; Lincoff, AM; Lorenz, TJ; O'Shea, JC; Talley, JD; Tcheng, JE	1
Kereiakes, DJ; Kukielka, G; Lorenz, T; Mueller, MN; Nanniazzi-Alaimo, L; Phillips, DR; Young, JJ	1
Batchelor, WB; Califf, RM; Cantor, WJ; Davidian, M; DiBattiste, PM; Dillard, P; Gretler, D; Harrington, RA; Huang, Y; Larsen, RL; Mantell, RM; Ohman, EM; Sketch, MH; Tcheng, JE; Tolleson, TR; Zhang, D; Zidar, JP	1
André, P; Conley, PB; Delaney, SM; LaRocca, T; Lin, PH; Phillips, DR; Sinha, U; Vincent, D	1

Reviews

1 review(s) available for phenylalanyl-prolyl-arginine-chloromethyl ketone and eptifibatide

Article	Year
Platelet aggregation inhibition with glycoprotein IIb--IIIa inhibitors. Journal of thrombosis and thrombolysis, 2001, Volume: 11, Issue:2 Topics: Abciximab; Adenosine Diphosphate; Amino Acid Chloromethyl Ketones; Antibodies, Monoclonal; Anticoagulants; Clinical Trials as Topic; Coronary Disease; Dose-Response Relationship, Drug; Drug Interactions; Eptifibatide; Heparin; Humans; Immunoglobulin Fab Fragments; Oligopeptides; Peptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Proteins; Receptors, Thrombin; Thrombin; Tirofiban; Tyrosine	2001

Article

Year

Platelet aggregation inhibition with glycoprotein IIb--IIIa inhibitors.

Journal of thrombosis and thrombolysis, 2001, Volume: 11, Issue:2

Topics: Abciximab; Adenosine Diphosphate; Amino Acid Chloromethyl Ketones; Antibodies, Monoclonal; Anticoagulants; Clinical Trials as Topic; Coronary Disease; Dose-Response Relationship, Drug; Drug Interactions; Eptifibatide; Heparin; Humans; Immunoglobulin Fab Fragments; Oligopeptides; Peptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Proteins; Receptors, Thrombin; Thrombin; Tirofiban; Tyrosine

2001

Trials

3 trial(s) available for phenylalanyl-prolyl-arginine-chloromethyl ketone and eptifibatide

Article	Year
Pharmacodynamics and pharmacokinetics of eptifibatide in patients with acute coronary syndromes: prospective analysis from PURSUIT. Circulation, 2001, Jul-24, Volume: 104, Issue:4 Topics: Adenosine Diphosphate; Aged; Amino Acid Chloromethyl Ketones; Angina, Unstable; Antithrombins; Coronary Disease; Eptifibatide; Female; Humans; Male; Middle Aged; Peptide Fragments; Peptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Receptors, Thrombin; Time Factors	2001
Clinical pharmacology of higher dose eptifibatide in percutaneous coronary intervention (the PRIDE study). The American journal of cardiology, 2001, Nov-15, Volume: 88, Issue:10 Topics: Amino Acid Chloromethyl Ketones; Angioplasty, Balloon, Coronary; Antithrombins; Coronary Disease; Dose-Response Relationship, Drug; Drug Administration Schedule; Eptifibatide; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged; Peptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex	2001
Randomized COMparison of platelet inhibition with abciximab, tiRofiban and eptifibatide during percutaneous coronary intervention in acute coronary syndromes: the COMPARE trial. Comparison Of Measurements of Platelet aggregation with Aggrastat, Reopro, an Circulation, 2002, Sep-17, Volume: 106, Issue:12 Topics: Abciximab; Acute Disease; Aged; Amino Acid Chloromethyl Ketones; Angina, Unstable; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Anticoagulants; Citric Acid; Coronary Disease; Eptifibatide; Female; Humans; Immunoglobulin Fab Fragments; Kinetics; Male; Middle Aged; Myocardial Infarction; Peptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Syndrome; Tirofiban; Tyrosine	2002

Other Studies

2 other study(ies) available for phenylalanyl-prolyl-arginine-chloromethyl ketone and eptifibatide

Article	Year
Differential effects of citrate versus PPACK anticoagulation on measured platelet inhibition by abciximab, eptifibatide and tirofiban. Journal of thrombosis and thrombolysis, 2001, Volume: 12, Issue:2 Topics: Abciximab; Amino Acid Chloromethyl Ketones; Antibodies, Monoclonal; Anticoagulants; Antithrombins; Blood Specimen Collection; Calcium; Chelating Agents; Citric Acid; Drug Interactions; Drug Monitoring; Eptifibatide; Humans; Immunoglobulin Fab Fragments; Peptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Tirofiban; Tyrosine	2001
Anticoagulants (thrombin inhibitors) and aspirin synergize with P2Y12 receptor antagonism in thrombosis. Circulation, 2003, Nov-25, Volume: 108, Issue:21 Topics: Amino Acid Chloromethyl Ketones; Animals; Anticoagulants; Antithrombins; Aspirin; Blood Coagulation; Collagen Type III; Diffusion Chambers, Culture; Drug Synergism; Eptifibatide; Factor Xa Inhibitors; Heparin; Heterocyclic Compounds; Humans; In Vitro Techniques; Membrane Proteins; Mice; Mice, Knockout; Microscopy, Video; Peptides; Perfusion; Platelet Aggregation; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Stress, Mechanical; Thiazoles; Thrombin; Thrombosis	2003

Article

Year

Differential effects of citrate versus PPACK anticoagulation on measured platelet inhibition by abciximab, eptifibatide and tirofiban.

Journal of thrombosis and thrombolysis, 2001, Volume: 12, Issue:2

Topics: Abciximab; Amino Acid Chloromethyl Ketones; Antibodies, Monoclonal; Anticoagulants; Antithrombins; Blood Specimen Collection; Calcium; Chelating Agents; Citric Acid; Drug Interactions; Drug Monitoring; Eptifibatide; Humans; Immunoglobulin Fab Fragments; Peptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Tirofiban; Tyrosine

2001

Anticoagulants (thrombin inhibitors) and aspirin synergize with P2Y12 receptor antagonism in thrombosis.

Circulation, 2003, Nov-25, Volume: 108, Issue:21

Topics: Amino Acid Chloromethyl Ketones; Animals; Anticoagulants; Antithrombins; Aspirin; Blood Coagulation; Collagen Type III; Diffusion Chambers, Culture; Drug Synergism; Eptifibatide; Factor Xa Inhibitors; Heparin; Heterocyclic Compounds; Humans; In Vitro Techniques; Membrane Proteins; Mice; Mice, Knockout; Microscopy, Video; Peptides; Perfusion; Platelet Aggregation; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Stress, Mechanical; Thiazoles; Thrombin; Thrombosis

2003