phenylalanyl-prolyl-arginine-chloromethyl ketone and arginine

phenylalanyl-prolyl-arginine-chloromethyl ketone has been researched along with arginine in 15 studies

Compound Research Comparison

Studies (phenylalanyl-prolyl-arginine-chloromethyl ketone)	Trials (phenylalanyl-prolyl-arginine-chloromethyl ketone)	Recent Studies (post-2010) (phenylalanyl-prolyl-arginine-chloromethyl ketone)	Studies (arginine)	Trials (arginine)	Recent Studies (post-2010) (arginine)
191	4	23	46,388	1,688	11,176

Protein Interaction Comparison

Protein	Taxonomy	phenylalanyl-prolyl-arginine-chloromethyl ketone (IC50)	arginine (IC50)
Cationic amino acid transporter 3	Homo sapiens (human)		283

Research

Studies (15)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (6.67)	18.7374
1990's	9 (60.00)	18.2507
2000's	4 (26.67)	29.6817
2010's	1 (6.67)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Loscalzo, J; Scharfstein, J	1
Gravett, PS; Oosthuizen, MM; Viljoen, CC	1
Banner, DW; Hadváry, P	1
Kaminski, M; McDonagh, J	1
Ku, DD; Zaleski, JK	1
Corr, PB; McHowat, J; Park, TH; Wolf, RA	1
Matsuoka, A; Sasaki, Y; Yamamoto, J; Yamashita, T	1
Grootenhuis, PD; Karplus, M	1
Drobot, D; Harding, SR; Lyon, AW; Lyon, ME	1
Deinum, J; Elg, M; Gustafsson, D	1
Bajzar, L; Fredenburgh, JC; Rischke, JA; Stewart, RJ; Weitz, JI	1
Bode, C; Darius, H; Diehm, C; Encke, A; Gulba, DC; Haas, S; Hacke, W; Puhl, W; Quante, M; Riess, H; Scharf, R; Schellong, S; Schrör, T; Schulte, KL; Tebbe, U; Van Aken, H	1
Imamura, T; Nemoto, E; Potempa, J; Shimauchi, H; Sugawara, S; Tada, H; Takada, H; Takahashi, N; Travis, J	1
Aguzzi, MS; Capogrossi, MC; De Cristofaro, R; Facchiano, A; Faraone, D; Giampietri, C; Totta, P	1
Hayashi, Y; Taguchi, A; Takayama, K; Yakushiji, F	1

Reviews

2 review(s) available for phenylalanyl-prolyl-arginine-chloromethyl ketone and arginine

Article	Year
Molecular approaches to antithrombotic therapy. Hospital practice (Office ed.), 1992, May-15, Volume: 27, Issue:5 Topics: Amino Acid Chloromethyl Ketones; Antithrombins; Arginine; Heparin; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Protease Inhibitors; Sulfonamides; Thrombin; Warfarin	1992
Anticoagulation: the present and future. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2001, Volume: 7, Issue:3 Topics: Administration, Oral; Amino Acid Chloromethyl Ketones; Anticoagulants; Arginine; Azetidines; Benzylamines; Binding Sites; Biological Availability; Blood Coagulation; Comorbidity; Coumarins; Drug Design; Embolism; Female; Forecasting; Glycine; Guanidines; Heart Diseases; Hemorrhage; Heparin; Heparin, Low-Molecular-Weight; Hirudin Therapy; Humans; Neoplasms; Pipecolic Acids; Pregnancy; Pregnancy Complications, Hematologic; Prodrugs; Safety; Serine; Stroke; Sulfonamides; Thrombin; Thrombophilia; Thrombosis	2001

Article

Year

Molecular approaches to antithrombotic therapy.

Hospital practice (Office ed.), 1992, May-15, Volume: 27, Issue:5

Topics: Amino Acid Chloromethyl Ketones; Antithrombins; Arginine; Heparin; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Protease Inhibitors; Sulfonamides; Thrombin; Warfarin

1992

Anticoagulation: the present and future.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2001, Volume: 7, Issue:3

Topics: Administration, Oral; Amino Acid Chloromethyl Ketones; Anticoagulants; Arginine; Azetidines; Benzylamines; Binding Sites; Biological Availability; Blood Coagulation; Comorbidity; Coumarins; Drug Design; Embolism; Female; Forecasting; Glycine; Guanidines; Heart Diseases; Hemorrhage; Heparin; Heparin, Low-Molecular-Weight; Hirudin Therapy; Humans; Neoplasms; Pipecolic Acids; Pregnancy; Pregnancy Complications, Hematologic; Prodrugs; Safety; Serine; Stroke; Sulfonamides; Thrombin; Thrombophilia; Thrombosis

2001

Other Studies

13 other study(ies) available for phenylalanyl-prolyl-arginine-chloromethyl ketone and arginine

Article	Year
Inactivation of arginine esterase E-I of Bitis gabonica venom by irreversible inhibitors including a water-soluble carbodiimide, a chloromethyl ketone and isatoic anhydride. The International journal of biochemistry, 1991, Volume: 23, Issue:10 Topics: Amino Acid Chloromethyl Ketones; Amino Acid Sequence; Arginine; Carboxylic Ester Hydrolases; Ethyldimethylaminopropyl Carbodiimide; Hydrogen-Ion Concentration; Kinetics; Molecular Sequence Data; Molecular Structure; Oxazines; Solubility; Viper Venoms	1991
Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors. The Journal of biological chemistry, 1991, Oct-25, Volume: 266, Issue:30 Topics: Amino Acid Chloromethyl Ketones; Antithrombins; Arginine; Benzamidines; Binding Sites; Dipeptides; Humans; Models, Molecular; Pipecolic Acids; Piperidines; Stereoisomerism; Sulfonamides; Thrombin; Trypsin	1991
Inhibited thrombins. Interactions with fibrinogen and fibrin. The Biochemical journal, 1987, Mar-15, Volume: 242, Issue:3 Topics: Amino Acid Chloromethyl Ketones; Arginine; Binding Sites; Chromatography, Affinity; Dansyl Compounds; Dipeptides; Fibrin; Fibrinogen; Fluorescent Dyes; Hirudins; Phenylmethylsulfonyl Fluoride; Protein Binding; Pyridoxal Phosphate; Thrombin	1987
Receptor mechanism of thrombin-induced endothelium-dependent and endothelium-independent coronary vascular effects in dogs. Journal of cardiovascular pharmacology, 1993, Volume: 22, Issue:4 Topics: Amino Acid Chloromethyl Ketones; Amino Acid Oxidoreductases; Amino Acid Sequence; Animals; Arginine; Arteries; Coronary Vessels; Dogs; Dose-Response Relationship, Drug; Endothelium, Vascular; Hemoglobins; In Vitro Techniques; Male; Molecular Sequence Data; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide Synthase; omega-N-Methylarginine; Peptide Fragments; Receptors, Thrombin; Thrombin	1993
Increased lysophosphatidylcholine content induced by thrombin receptor stimulation in adult rabbit cardiac ventricular myocytes. Cardiovascular research, 1994, Volume: 28, Issue:8 Topics: Amino Acid Chloromethyl Ketones; Animals; Arginine; Calcium; Cells, Cultured; Dansyl Compounds; Female; Lysophosphatidylcholines; Male; Myocardium; Peptide Fragments; Rabbits; Receptors, Cell Surface; Receptors, Thrombin; Stimulation, Chemical; Thrombin	1994
The antithrombotic effect of low molecular weight synthetic thrombin inhibitors, argatroban and PPACK, on He-Ne laser-induced thrombosis in rat mesenteric microvessels. Thrombosis research, 1993, Jan-01, Volume: 69, Issue:1 Topics: Amino Acid Chloromethyl Ketones; Animals; Antithrombins; Arginine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Male; Mesentery; Microcirculation; Pipecolic Acids; Platelet Aggregation; Rats; Rats, Wistar; Sulfonamides; Thrombin; Thrombosis	1993
Functionality map analysis of the active site cleft of human thrombin. Journal of computer-aided molecular design, 1996, Volume: 10, Issue:1 Topics: Amino Acid Chloromethyl Ketones; Amino Acid Sequence; Arginine; Binding Sites; Dipeptides; Humans; Models, Molecular; Molecular Probes; Molecular Sequence Data; Molecular Structure; Pipecolic Acids; Piperidines; Protein Conformation; Serine Proteinase Inhibitors; Software; Sulfonamides; Thrombin	1996
Use of thrombin inhibitors ex vivo allows critical care clinical chemistry and hematology testing on common specimens. Clinical biochemistry, 1997, Volume: 30, Issue:2 Topics: Amino Acid Chloromethyl Ketones; Antithrombins; Arginine; Blood Chemical Analysis; Blood Preservation; Blood Specimen Collection; Critical Care; Humans; Pipecolic Acids; Sulfonamides	1997
The importance of enzyme inhibition kinetics for the effect of thrombin inhibitors in a rat model of arterial thrombosis. Thrombosis and haemostasis, 1997, Volume: 78, Issue:4 Topics: Amino Acid Chloromethyl Ketones; Animals; Anticoagulants; Arginine; Azetidines; Benzylamines; Carotid Artery Thrombosis; Dose-Response Relationship, Drug; Fibrinolytic Agents; Glycine; Hemodynamics; Heparin; Hirudin Therapy; Hirudins; Kinetics; Male; Oligopeptides; Partial Thromboplastin Time; Peptide Fragments; Pipecolic Acids; Piperidines; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sulfonamides; Thrombin; Thrombin Time	1997
Thrombin-activable fibrinolysis inhibitor attenuates (DD)E-mediated stimulation of plasminogen activation by reducing the affinity of (DD)E for tissue plasminogen activator. A potential mechanism for enhancing the fibrin specificity of tissue plasminogen The Journal of biological chemistry, 2000, Nov-24, Volume: 275, Issue:47 Topics: Amino Acid Chloromethyl Ketones; Arginine; Carboxypeptidase B; Carboxypeptidase B2; Carboxypeptidases; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Fibrin; Fibrin Fibrinogen Degradation Products; Fibrinolysin; Humans; Kinetics; Lysine; Models, Chemical; Tissue Plasminogen Activator	2000
Proteolysis of CD14 on human gingival fibroblasts by arginine-specific cysteine proteinases from Porphyromonas gingivalis leading to down-regulation of lipopolysaccharide-induced interleukin-8 production. Infection and immunity, 2002, Volume: 70, Issue:6 Topics: Adhesins, Bacterial; ADP-ribosyl Cyclase; Amino Acid Chloromethyl Ketones; Antigens, CD; Arginine; CD40 Antigens; CD59 Antigens; Cell Membrane; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Down-Regulation; Fibroblasts; Gingipain Cysteine Endopeptidases; Gingiva; GPI-Linked Proteins; Hemagglutinins; Humans; Interleukin-8; Lipopolysaccharide Receptors; Lipopolysaccharides; Membrane Glycoproteins; Porphyromonas gingivalis	2002
Thrombin-mediated impairment of fibroblast growth factor-2 activity. The FEBS journal, 2009, Volume: 276, Issue:12 Topics: Amino Acid Chloromethyl Ketones; Arginine; Binding Sites; Cell Line; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromatography, High Pressure Liquid; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Fibroblast Growth Factor 2; Flow Cytometry; Humans; Hydrolysis; Isoleucine; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Peptide Fragments; Phosphorylation; Protein Binding; Receptors, Thrombin; Thrombin	2009
Identification of a degrading enzyme in human serum that hydrolyzes a C-terminal core sequence of neuromedin U. Biopolymers, 2016, Nov-04, Volume: 106, Issue:4 Topics: Amino Acid Chloromethyl Ketones; Arginine; Humans; Hydrolysis; Neuropeptides; Pipecolic Acids; Serum; Sulfonamides; Thrombin	2016