phenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide has been researched along with enkephalin, ala(2)-mephe(4)-gly(5)- in 13 studies
| Studies (phenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide) | Trials (phenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide) | Recent Studies (post-2010) (phenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide) | Studies (enkephalin, ala(2)-mephe(4)-gly(5)-) | Trials (enkephalin, ala(2)-mephe(4)-gly(5)-) | Recent Studies (post-2010) (enkephalin, ala(2)-mephe(4)-gly(5)-) |
|---|---|---|---|---|---|
| 276 | 0 | 55 | 2,727 | 1 | 374 |
| 7 | 0 | 5 | 151 | 0 | 71 |
| Protein | Taxonomy | phenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide (IC50) | enkephalin, ala(2)-mephe(4)-gly(5)- (IC50) |
|---|---|---|---|
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | 0.003 | |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | 0.003 | |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | 0.003 | |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | 0.003 | |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | 0.003 | |
| Delta-type opioid receptor | Mus musculus (house mouse) | 1.2415 | |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0132 | |
| Mu-type opioid receptor | Homo sapiens (human) | 0.004 | |
| Delta-type opioid receptor | Homo sapiens (human) | 0.0014 | |
| Mu-type opioid receptor | Mus musculus (house mouse) | 0.0048 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.0283 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (61.54) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Long, JB; Rothman, RB; Yang, HY | 1 |
| Dickenson, AH; Magnuson, DS; Roques, BP; Simonnet, G; Sullivan, AF | 1 |
| Maier, SF; Mooney-Heiberger, K; Watkins, LR; Wiertelak, EP; Yang, HY | 1 |
| Dupouy, V; Zajac, JM | 1 |
| Becketts, K; Cadet, JL; Emilien, B; Goodman, CB; Rothman, RB | 1 |
| Rebeyrolles, S; Roumy, M; Zajac, JM | 1 |
| Desprat, C; Zajac, JM | 1 |
| Roumy, M; Zajac, J | 1 |
| Chen, X; Harris, KH; Jhamandas, JH; Zidichouski, JA | 1 |
| Nicklous, DM; Simansky, KJ | 1 |
| Mollereau, C; Roumy, M; Zajac, JM | 1 |
| Chang, XM; Fang, Q; Han, ZL; Li, N; Li, XH; Pan, JX; Tang, HH; Wang, P; Wang, R; Wang, ZL; Zheng, T | 1 |
| Bihel, F; Drieu la Rochelle, A; Elhabazi, K; Gizzi, P; Henningsen, JB; Ilien, B; Kugler, V; Quillet, R; Schmitt, M; Schneider, S; Simonin, F; Simonneaux, V; Utard, V | 1 |
13 other study(ies) available for phenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide and enkephalin, ala(2)-mephe(4)-gly(5)-
| Article | Year |
|---|---|
Upregulation of rat brain opioid receptors by the chronic administration of morphine: possible evidence for an anti-opiate model of tolerance and dependence.
Topics: Animals; Brain Chemistry; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Immunoglobulin G; Injections, Intraventricular; Ligands; Male; Morphine; Morphine Dependence; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Up-Regulation | 1990 |
Differential interactions of cholecystokinin and FLFQPQRF-NH2 with mu and delta opioid antinociception in the rat spinal cord.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Evoked Potentials; Injections, Spinal; Male; Nerve Fibers; Neurons; Oligopeptides; Pain; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sincalide; Spinal Cord | 1990 |
The nature of conditioned anti-analgesia: spinal cord opiate and anti-opiate neurochemistry.
Topics: Analgesia; Analgesics; Animals; Conditioning, Classical; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Immune Sera; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Proglumide; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Spinal Cord | 1994 |
Effects of neuropeptide FF analogs on morphine analgesia in the nucleus raphe dorsalis.
Topics: Amino Acid Sequence; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Microinjections; Molecular Sequence Data; Morphine; Neuropeptides; Oligopeptides; Pain Measurement; Pain Threshold; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 1995 |
Downregulation of mu-opioid binding sites following chronic administration of neuropeptide FF (NPFF) and morphine.
Topics: Analgesics, Opioid; Animals; Autoradiography; Brain; Corpus Striatum; Down-Regulation; Drug Administration Routes; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Morphine; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Subcellular Fractions; Thalamus; Tissue Distribution | 1996 |
Neuropeptide FF reverses the effect of mu-opioid on Ca2+ channels in rat spinal ganglion neurones.
Topics: Analgesics; Aniline Compounds; Animals; Calcium Channels; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ganglia, Spinal; Narcotic Antagonists; Narcotics; Neurons; Oligopeptides; Potassium Chloride; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Xanthenes | 1996 |
Differential modulation of mu- and delta-opioid antinociception by neuropeptide FF receptors in young mice.
Topics: Age Factors; Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Neuropeptides; Nociceptors; Oligopeptides; Receptors, Neuropeptide; Receptors, Opioid, delta; Receptors, Opioid, mu | 1997 |
Neuropeptide FF selectively attenuates the effects of nociceptin on acutely dissociated neurons of the rat dorsal raphe nucleus.
Topics: Aminopyridines; Analgesics, Opioid; Animals; Barium Compounds; Biological Transport; Calcium; Chlorides; Dose-Response Relationship, Drug; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; In Vitro Techniques; Narcotic Antagonists; Neurons; Nociceptin; Oligopeptides; Opioid Peptides; Piperazines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, mu; Serotonin; Serotonin Antagonists; Vasodilator Agents | 1999 |
Synaptic actions of neuropeptide FF in the rat parabrachial nucleus: interactions with opioid receptors.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Electric Conductivity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Excitatory Postsynaptic Potentials; GABA Antagonists; In Vitro Techniques; Ligands; Male; Naloxone; Narcotic Antagonists; Oligopeptides; Patch-Clamp Techniques; Peptides; Picrotoxin; Pons; Potassium; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Tetrahydroisoquinolines; Tetrodotoxin | 2000 |
Neuropeptide FF exerts pro- and anti-opioid actions in the parabrachial nucleus to modulate food intake.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drinking; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Feeding Behavior; Hyperphagia; Immunohistochemistry; Male; Naloxone; Narcotic Antagonists; Oligopeptides; Pons; Rats; Rats, Sprague-Dawley | 2003 |
Staurosporine differentiation of NPFF2 receptor-transfected SH-SY5Y neuroblastoma cells induces selectivity of NPFF activity towards opioid receptors.
Topics: Calcium; Cell Differentiation; Cell Line, Tumor; Cell Membrane; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Humans; Neuroblastoma; Neuropeptide Y; Oligopeptides; Receptors, Neuropeptide; Receptors, Opioid; Staurosporine | 2007 |
Opposite effects of neuropeptide FF on central antinociception induced by endomorphin-1 and endomorphin-2 in mice.
Topics: Adamantane; Animals; Benzeneacetamides; Dipeptides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Injections, Intraventricular; Male; Mice; Naltrexone; Nociception; Oligopeptides; Pyrrolidines | 2014 |
Identification of an
Topics: Analgesics, Opioid; Animals; Cricetinae; Dipeptides; Female; Fentanyl; Half-Life; Humans; Hyperalgesia; Luteinizing Hormone; Male; Mice; Mice, Inbred C57BL; Neuropeptides; Protein Isoforms; Receptors, Neuropeptide; Receptors, Opioid; Structure-Activity Relationship | 2021 |