Compounds > phenylalanine

phenylalanine and tr 14035

phenylalanine has been researched along with tr 14035 in 9 studies

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (88.89)29.6817
2010's0 (0.00)24.3611
2020's1 (11.11)2.80

Authors

AuthorsStudies
Cardarelli, PM; Connell, S; Griffith, RC; Gudmundsson, KS; Jayakumar, H; Lazarides, E; Liang, J; Mah, JR; Martin, R; Nomura, S; Nowlin, DM; Sircar, I; Teegarden, BR1
Amo, S; Bargatze, RF; Benson, E; Cao, J; De Laszlo, SE; Detmers, PA; Egger, LA; Hagmann, WK; Kidambi, U; Kopka, IE; Lanza, T; Lin, LS; Lingham, R; McCauley, E; Mumford, RA; Pikounis, B; Schmidt, JA; Tong, S; Van Riper, G; Warwood, S; Young, DN1
Cao, J; Cornebise, MA; de Laszlo, SE; Dean, DC; Detmers, PA; Egger, LA; Hagmann, WK; Jones, AN; Kidambi, U; Lanza, TJ; Lee, WC; Lin, LS; McCallum, C; McCauley, E; Mumford, RA; Pepinsky, RB; Raab, CE; Schmidt, JA; Scott, DM; Van Riper, G; Wallace, MA; Yang, G; Young, DN1
Berens, KL; Biediger, RJ; Dixon, RA; Holland, GW; Vanderslice, P; Woodside, DG1
Kume, T; Ogasawara, Y; Tsuda-Tsukimoto, M2
Alfón, J; Cortijo, J; Gómez, LA; Iranzo, A; Merlos, M; Montesinos, JL; Morcillo, EJ; Nabah, YN; Sanz, MJ1
Iwanaga, T; Kume, T; Maeda, T; Tamai, I; Tsuda-Tsukimoto, M1
Connolly, PJ; Fang, A; Shao, J; Veazey, RS; Wang, X; Xu, H; Ziani, W1

Reviews

1 review(s) available for phenylalanine and tr 14035

ArticleYear
Development of cell adhesion molecule antagonists as therapeutics for asthma and COPD.
    Pulmonary pharmacology & therapeutics, 2004, Volume: 17, Issue:1

    Topics: Animals; Asthma; Biphenyl Compounds; Cell Adhesion Molecules; Chemistry, Pharmaceutical; Clinical Trials as Topic; Humans; Integrin alpha4beta1; Mannose; Mannosides; Phenylalanine; Pulmonary Disease, Chronic Obstructive; Selectins

2004

Other Studies

8 other study(ies) available for phenylalanine and tr 14035

ArticleYear
Synthesis and SAR of N-benzoyl-L-biphenylalanine derivatives: discovery of TR-14035, a dual alpha(4)beta(7)/alpha(4)beta(1) integrin antagonist.
    Bioorganic & medicinal chemistry, 2002, Volume: 10, Issue:6

    Topics: Cell Adhesion; Humans; Inhibitory Concentration 50; Integrin alpha4beta1; Integrins; Jurkat Cells; Molecular Structure; Phenylalanine; Structure-Activity Relationship; Tumor Cells, Cultured

2002
Alpha(4)beta(7)/alpha(4)beta(1) dual integrin antagonists block alpha(4)beta(7)-dependent adhesion under shear flow.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 302, Issue:1

    Topics: Animals; Antibodies, Blocking; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Cell Adhesion; Cell Adhesion Molecules; Cyclophosphamide; Doxorubicin; Endothelium, Vascular; Etoposide; Female; Flow Cytometry; Humans; Immunoglobulin G; Immunoglobulins; Integrin alpha4beta1; Integrins; Ligands; Lymphocytes; Methotrexate; Mice; Mice, Inbred BALB C; Mucoproteins; Peyer's Patches; Phenylalanine; Receptors, Lymphocyte Homing; Recombinant Fusion Proteins; Rheology

2002
A small molecule alpha4beta1/alpha4beta7 antagonist differentiates between the low-affinity states of alpha4beta1 and alpha4beta7: characterization of divalent cation dependence.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 306, Issue:3

    Topics: Binding Sites; Cations, Divalent; Cell Line; Dipeptides; Humans; Integrin alpha4beta1; Integrins; Jurkat Cells; K562 Cells; Kinetics; Ligands; Phenylalanine; Phenylurea Compounds; Protein Binding; Radioligand Assay; Sulfur Radioisotopes; Tumor Cells, Cultured; Vascular Cell Adhesion Molecule-1

2003
Role of human liver cytochrome P450 2C9 in the metabolism of a novel alpha4beta1/alpha4beta7 dual antagonist, TR-14035.
    Drug metabolism and pharmacokinetics, 2005, Volume: 20, Issue:2

    Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Humans; In Vitro Techniques; Integrin alpha4beta1; Integrins; Isoenzymes; Microsomes, Liver; Phenylalanine; Polymorphism, Genetic; Recombinant Proteins

2005
Pharmacokinetics and metabolism of TR-14035, a novel antagonist of a4ss1/a4ss7 integrin mediated cell adhesion, in rat and dog.
    Xenobiotica; the fate of foreign compounds in biological systems, 2005, Volume: 35, Issue:4

    Topics: Animals; Cell Adhesion; Dogs; Humans; Integrin alpha4beta1; Integrins; Male; Phenylalanine; Rats; Rats, Sprague-Dawley; Species Specificity

2005
A small molecule, orally active, alpha4beta1/alpha4beta7 dual antagonist reduces leukocyte infiltration and airway hyper-responsiveness in an experimental model of allergic asthma in Brown Norway rats.
    British journal of pharmacology, 2006, Volume: 147, Issue:6

    Topics: Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Gene Expression Regulation; Integrin alpha4beta1; Integrins; Interleukin-4; Interleukin-5; Leukocyte Rolling; Leukocytes; Lung; Male; Mesenteric Veins; Ovalbumin; Phenylalanine; Pneumonia; Rats; Rats, Inbred BN; RNA, Messenger; Serotonin

2006
Characterization of hepatobiliary transport systems of a novel alpha4beta1/alpha4beta7 dual antagonist, TR-14035.
    Pharmaceutical research, 2006, Volume: 23, Issue:11

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bile; Biological Transport; Female; Hepatocytes; Liver; Male; Mice; Mice, Knockout; Oocytes; Organic Anion Transporters, Sodium-Independent; Phenylalanine; Polymorphism, Single Nucleotide; Rats; Rats, Sprague-Dawley

2006
Mucosal integrin α4β7 blockade fails to reduce the seeding and size of viral reservoirs in SIV-infected rhesus macaques.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021, Volume: 35, Issue:2

    Topics: Animals; Antibodies, Neutralizing; Integrins; Lymphoid Tissue; Macaca mulatta; Mucous Membrane; Phenylalanine; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Virus Replication

2021