phenylalanine has been researched along with thiazoles in 50 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (24.00) | 18.7374 |
| 1990's | 3 (6.00) | 18.2507 |
| 2000's | 22 (44.00) | 29.6817 |
| 2010's | 10 (20.00) | 24.3611 |
| 2020's | 3 (6.00) | 2.80 |
| Authors | Studies |
|---|---|
| Guyer, RL; Lovins, RE; Schnute, WC; Todd, CW | 1 |
| Cramer, F; Freist, W; Maelicke, A; Sprinz, M | 1 |
| Bahramian, MB; Middleton, RB | 1 |
| Ellis, S; Fairwell, T; Lovins, RE | 1 |
| Iwashima, A; Kawasaki, T; Nakamura, M; Nose, Y | 1 |
| Iwashima, A; Nose, Y | 2 |
| Feingold, DS; Vance, DE | 1 |
| Kopiĭchuk, II | 1 |
| Fairwell, T; Lovins, RE | 1 |
| Baldwin, RE; Cloninger, MR | 1 |
| Ito, S; Li, Q; Mita, S; Ukai, Y | 1 |
| Smits, P; Tack, CJ | 1 |
| Bell, D; McDermott, BJ | 1 |
| Füchtenbusch, M; Schatz, H; Standl, E | 1 |
| Aljada, A; Assian, E; Dandona, P; Garg, R; Ghanim, H; Hamouda, W; Mohanty, P | 1 |
| Knaggs, AR | 1 |
| Archer, E; Behrendt, R; Bignon, E; Escrieut, C; Fourmy, D; Gigoux, V; Maigret, B; Moroder, L; Pradayrol, L; Silvente-Poirot, S; Verrier, S | 1 |
| Koivisto, V | 1 |
| Foley, JE; Gatlin, MR; Rosenstock, J; Shen, SG | 1 |
| Hussar, DA | 1 |
| Mori, Y; Sekihara, H | 1 |
| Göke, B; Parhofer, KG | 1 |
| Gordon, DJ; Meredith, SC | 1 |
| Anglard, P; Bonnafous, S; Chavey, C; Mari, B; Monthouel, MN; Tartare-Deckert, S; Van Obberghen, E | 1 |
| LAX, SR; RAVEL, JM; SHIVE, W; SMITH, LC | 1 |
| Hidalgo, FJ; Zamora, R | 1 |
| Almeida, FC; Ferrão-Gonzales, AD; Ferreira, A; Foguel, D; Juliano, L; Moreau, VH; Robbs, BK; Silva, JL; Valente, AP | 1 |
| Keasling, JD; Muller, SJ; Wang, K | 1 |
| Bemporad, F; Chiti, F; Stefani, M; Taddei, N | 1 |
| Bold, G; Furet, P; Guagnano, V; Meyer, T; Roesel, J | 1 |
| Baccarani, M; Bosi, C; Castagnetti, F; Cilloni, D; Colarossi, S; Giannoulia, P; Gnani, A; Iacobucci, I; Luatti, S; Martinelli, G; Marzocchi, G; Palandri, F; Paolini, S; Piccaluga, PP; Rondoni, M; Rosti, G; Saglio, G; Soverini, S; Testoni, N | 1 |
| Auge, N; Coatrieux, C; Hannun, Y; Itohara, S; Negre-Salvayre, A; Parini, A; Salvayre, R; Sanson, M | 1 |
| Chen, DY; Dethe, DH; Leung, GY; Nicolaou, KC; Zou, B | 1 |
| Gupta, R; Marek, P; Raleigh, DP | 1 |
| Meredith, SC; Orgel, JP; Sciarretta, KL; Tycko, R | 1 |
| Divoka, M; Divoky, V; Faber, E; Indrak, K; Jarosova, M; Mojzikova, R; Plachy, R; Rozmanova, S; Stastny, M | 1 |
| Ang, BU; Kirschner, RE; Nah, HD; Spivak, RM | 1 |
| Av-Gay, Y; Borrelli, S; Ko, M; Martinez-Gutierrez, F; Mohan, S; Partha, SK; Pinto, BM; Sanders, DA; Zandberg, WF | 1 |
| Bassan, R; Bussini, A; Castagnetti, F; Gnani, A; Intermesoli, T; Rosti, G; Soverini, S; Spinelli, O | 1 |
| Cortez, LM; Kumar, J; Renault, L; Sim, VL; Young, HS | 1 |
| Chen, QH; Li, ZY; Lin, SJ; Yuwen, L; Zhang, FL; Zhao, YL | 1 |
| Du, W; He, L; Lin, J; Wang, X; Zhao, C | 1 |
| Ghosh, C; Haldar, J; Konai, MM; Samaddar, S; Yarlagadda, V | 1 |
| Asano, A; Doi, M; Minoura, K; Yamada, T | 1 |
| Bear, CE; Casavola, V; Laselva, O; Molinski, S | 1 |
| Cragg, PJ; Padnya, PL; Shurpik, DN; Stoikov, II | 1 |
| Baroni, D; Brandas, C; Cichero, E; Ludovico, A; Millo, E; Moran, O; Parodi, A | 1 |
| Bai, Z; Cai, C; Chen, J; Liu, S; Sheng, W; Wang, F; Wang, H; Xiao, X; Xie, R; Zheng, J | 1 |
6 review(s) available for phenylalanine and thiazoles
| Article | Year |
|---|---|
New drugs for diabetes.
Topics: Carbamates; Chromans; Cyclohexanes; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Insulin Resistance; Metformin; Nateglinide; Phenylalanine; Piperidines; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Clinical efficacy of new thiazolidinediones and glinides in the treatment of type 2 diabetes mellitus.
Topics: Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Nateglinide; Phenylalanine; Pioglitazone; Piperidines; Rosiglitazone; Thiazoles; Thiazolidinediones | 2000 |
The biosynthesis of shikimate metabolites.
Topics: 3-Deoxy-7-Phosphoheptulonate Synthase; 3-Phosphoshikimate 1-Carboxyvinyltransferase; Alkyl and Aryl Transferases; Animals; Anthranilate Synthase; Bacteria; Betalains; Catalysis; Chorismate Mutase; Coumarins; Flavonoids; Hydro-Lyases; Indoleacetic Acids; Indoles; Intramolecular Transferases; Lignans; Molecular Structure; Penicillium; Phenylalanine; Phenylpropionates; Phosphorus-Oxygen Lyases; Prephenate Dehydratase; Prephenate Dehydrogenase; Pristinamycin; Pyrrolnitrin; Quaternary Ammonium Compounds; Quinones; Shikimic Acid; Staurosporine; Tannins; Thiazoles; Thyroxine; Tryptophan; Tyrosine; Ubiquinone | 2001 |
[Insulin analogs and new oral antidiabetic drugs].
Topics: Administration, Oral; Carbamates; Cyclohexanes; Diabetes Mellitus; Dose-Response Relationship, Drug; Glucose; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Nateglinide; Phenylalanine; Piperidines; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors | 1999 |
[Adverse effects of oral hypoglycemic agents].
Topics: Acarbose; Administration, Oral; Biguanides; Cyclohexanes; Drug Interactions; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Insulin Secretion; Nateglinide; Phenylalanine; Pioglitazone; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones | 2002 |
Antimicrobial Activity of Calixarenes and Related Macrocycles.
Topics: Amino Acid Motifs; Animals; Anti-Infective Agents; Biofilms; Calixarenes; Drug Delivery Systems; Glycosylation; Humans; Lectins; Metals; Nanoparticles; Oxazoles; Phenylalanine; Prodrugs; Solubility; Sulfonamides; Thiadiazoles; Thiazoles; Vancomycin; Water | 2020 |
2 trial(s) available for phenylalanine and thiazoles
| Article | Year |
|---|---|
Nuclear factor-kappaB suppressive and inhibitor-kappaB stimulatory effects of troglitazone in obese patients with type 2 diabetes: evidence of an antiinflammatory action?
Topics: Adult; Anti-Inflammatory Agents; Blood Glucose; C-Reactive Protein; Chemokine CCL2; Cholesterol; Chromans; Diabetes Mellitus; Diabetes Mellitus, Type 2; Female; Humans; I-kappa B Proteins; Insulin; Intercellular Adhesion Molecule-1; Leukocytes, Mononuclear; Linoleic Acid; Linoleic Acids; Linoleic Acids, Conjugated; Male; Middle Aged; NADPH Oxidases; Neutrophils; NF-kappa B; Obesity; Phenylalanine; Phosphoproteins; Plasminogen Activator Inhibitor 1; Reactive Oxygen Species; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone; Tyrosine | 2001 |
Combination therapy with nateglinide and a thiazolidinedione improves glycemic control in type 2 diabetes.
Topics: Adult; Aged; Cyclohexanes; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hyperglycemia; Hypoglycemic Agents; Male; Middle Aged; Nateglinide; Phenylalanine; Thiazoles; Thiazolidinediones; Treatment Outcome | 2002 |
42 other study(ies) available for phenylalanine and thiazoles
| Article | Year |
|---|---|
The removal of contaminating quadrol by boric acid extraction prior to mass spectralanalysis of amino acid thiazolinones.
Topics: Amino Acids; Aniline Compounds; Boric Acids; Ethylenediamines; Lysine; Mass Spectrometry; Methods; Phenylalanine; Serine; Thiazoles; Threonine | 1975 |
Incorporation of 3-methyl-2-benzothiazolone hydrazone into the anticodon loop of tRNA Phe from yeast.
Topics: Benzothiazoles; Chemical Phenomena; Chemistry; Chromatography, DEAE-Cellulose; Genetic Code; Hydrazones; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Oligonucleotides; Pentosephosphates; Phenylalanine; Ribose; RNA, Transfer; Saccharomyces cerevisiae; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Temperature; Thiazoles; Transfer RNA Aminoacylation | 1972 |
Reversal by aromatic amino acids of 2-thiazole-DL-alanine inhibition of Salmonella typhimurium.
Topics: Amino Acids; Cell-Free System; Enzyme Repression; Feedback; Histidine; Hydro-Lyases; Membrane Transport Proteins; Phenylalanine; Salmonella typhimurium; Spectrophotometry; Stereoisomerism; Thiazoles; Tryptophan; Tyrosine | 1973 |
Quantitative protein sequencing using mass spectrometry: N-terminal sequence analysis of small quantities of peptides from the mass spectral analysis of the N-methylthiourea derivatives.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Chemical Phenomena; Chemistry; Cyclization; Evaluation Studies as Topic; Fluoroacetates; Glutamates; Glycine; Hot Temperature; Hydantoins; Mass Spectrometry; Methods; Methylamines; Oligopeptides; Peptides; Phenylalanine; Proteins; Thiazoles; Thiocyanates; Thiourea; Volatilization | 1972 |
Effect of amino acids and purine bases on thiamine synthesis by Escherichia coli.
Topics: Adenine; Amino Acids; Aspartic Acid; Culture Media; Cystine; Cytosine; Escherichia coli; Glutamates; Glycine; Guanine; Histidine; Hypoxanthines; Inositol; Isoleucine; Leucine; Methionine; Phenylalanine; Proline; Purines; Serine; Thiamine; Thiazoles; Threonine; Thymine; Tyrosine; Uracil; Valine | 1968 |
Inhibition by phenylalanine of thiazole biosynthesis in Escherichia coli.
Topics: Depression, Chemical; Escherichia coli; Genetics, Microbial; Mutation; Phenylalanine; Shikimic Acid; Thiamine; Thiazoles; Tryptophan; Tyrosine | 1970 |
Additive Edman degradation to sequence small peptides.
Topics: Alanine; Amino Acid Sequence; Aspartic Acid; Chromatography, Gas; Hydantoins; Methods; Peptides; Phenylalanine; Serine; Silicones; Thiazoles; Valine | 1971 |
Incorporation of glycine in pyrimidine and thiazole moieties of thiamine in Escherichia coli.
Topics: Adenine; Alcohols; Carbon Isotopes; Chromatography, Ion Exchange; Escherichia coli; Genetics, Microbial; Glycine; Mutation; Phenylalanine; Pyrimidines; Thiamine; Thiazoles | 1971 |
[Synthesis and properties of rhodanines received from beta-phenyl-alpha-alanine].
Topics: Chemistry Techniques, Analytical; Mycobacterium tuberculosis; Phenylalanine; Thiazoles | 1969 |
Quantitative protein sequencing using mass spectrometry: mass spectral analysis of 2-anilino-5-thiazolinone derivatives of amino acids without prior conversion to the phenyl thiohydantoins.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Aniline Compounds; Animals; Arginine; Autoanalysis; Cattle; Chemical Phenomena; Chemistry; Drug Stability; Glutamates; Hydantoins; Lysine; Mass Spectrometry; Methods; Phenylalanine; Ribonucleases; Serine; Sulfides; Thiazoles; Thiocyanates; Threonine; Tyrosine | 1971 |
Aspartylphenylalanine methyl ester: a low-calorie sweetener.
Topics: Analysis of Variance; Aspartic Acid; Cyclamates; Dipeptides; Esters; Humans; Osmolar Concentration; Phenylalanine; Saccharin; Solutions; Sucrose; Sweetening Agents; Taste; Thiazoles | 1970 |
A novel synthetic inhibitor of endopeptidase-24.15.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Brain; Kinetics; Male; Metalloendopeptidases; Molecular Structure; Neprilysin; Oligopeptides; Phenylalanine; Protease Inhibitors; Rats; Rats, Wistar; Thiazoles; Thiazolidines | 1996 |
Troglitazone does not initiate hypertrophy but can sensitise cardiomyocytes to growth effects of serum.
Topics: Animals; Cattle; Cell Differentiation; Cell Survival; Chromans; Culture Media; Dose-Response Relationship, Drug; Drug Interactions; Endothelin-1; Fetal Blood; Glucose; Heart Ventricles; Hydrogen-Ion Concentration; Hypertrophy; Hypoglycemic Agents; Insulin; Insulin-Like Growth Factor I; Male; Myocardium; Norepinephrine; Phenylalanine; Protein Kinase C; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
[Type 2 diabetes. Regulating insulin according to need].
Topics: Blood Glucose; Cyclohexanes; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Insulin; Metformin; Nateglinide; Phenylalanine; Thiazoles; Thiazolidinediones | 2001 |
The biologically crucial C terminus of cholecystokinin and the non-peptide agonist SR-146,131 share a common binding site in the human CCK1 receptor. Evidence for a crucial role of Met-121 in the activation process.
Topics: Amino Acid Sequence; Amino Acids; Animals; Binding Sites; Cholecystokinin; COS Cells; Dose-Response Relationship, Drug; Humans; Indoles; Kinetics; Ligands; Methionine; Models, Chemical; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Phenylalanine; Protein Binding; Protein Structure, Tertiary; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Thiazoles; Transfection | 2002 |
New drugs 2002, part 1.
Topics: Amides; Aminosalicylic Acids; Anti-Ulcer Agents; Antipsychotic Agents; Bimatoprost; Cloprostenol; Cyclohexanes; Drug Approval; Drug Therapy; Drug-Related Side Effects and Adverse Reactions; Galantamine; Glaucoma; Gonadotropin-Releasing Hormone; Humans; Hypoglycemic Agents; Insulin; Insulin Glargine; Insulin, Long-Acting; Lipids; Mesalamine; Nateglinide; Nootropic Agents; Phenylalanine; Phenylhydrazines; Piperazines; Thiazoles; Travoprost | 2002 |
[Glinides and glitazones in diabetes treatment. Are they really effective?].
Topics: Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Insulin; Nateglinide; Phenylalanine; Pioglitazone; Piperidines; Rosiglitazone; Thiazoles; Thiazolidinediones; Treatment Outcome | 2002 |
Probing the role of backbone hydrogen bonding in beta-amyloid fibrils with inhibitor peptides containing ester bonds at alternate positions.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Benzothiazoles; Congo Red; Cross-Linking Reagents; Diphenylhexatriene; Esters; Fluorescent Dyes; Humans; Hydrogen Bonding; Molecular Sequence Data; Peptide Fragments; Phenylalanine; Protein Binding; Protein Conformation; Spectrometry, Fluorescence; Spectrometry, Mass, Electrospray Ionization; Thiazoles; Ultracentrifugation | 2003 |
Matrix metalloproteinases are differentially expressed in adipose tissue during obesity and modulate adipocyte differentiation.
Topics: Adipocytes; Animals; Blood Vessels; CCAAT-Enhancer-Binding Protein-beta; Cell Differentiation; Diet; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Hypoglycemic Agents; Male; Matrix Metalloproteinase 12; Matrix Metalloproteinase 2; Matrix Metalloproteinase 3; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Matrix Metalloproteinases, Membrane-Associated; Matrix Metalloproteinases, Secreted; Metalloendopeptidases; Mice; Mice, Inbred AKR; Mice, Inbred C57BL; Mice, Obese; Mitosis; Obesity; Phenylalanine; Protease Inhibitors; RNA, Messenger; Rosiglitazone; Stromal Cells; Thiazoles; Thiazolidinediones; Thiophenes; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-3 | 2003 |
THE EFFECTS OF PHENYLALANINE AND TYROSINE ANALOGS ON THE SYNTHESIS AND ACTIVITY OF 3-DEOXY-D-ARABINO-HEPTULOSONIC ACID 7-PHOSPHATE SYNTHETASES.
Topics: Carbohydrate Metabolism; Enzyme Inhibitors; Escherichia coli; Ligases; Mutation; Naphthalenes; Pharmacology; Phenylalanine; Phosphates; Pyridines; Research; Thiazoles; Thiophenes; Tyrosine | 1964 |
Strecker-type degradation produced by the lipid oxidation products 4,5-epoxy-2-alkenals.
Topics: Acetaldehyde; Aldehydes; Epoxy Compounds; Gas Chromatography-Mass Spectrometry; Hydrogen-Ion Concentration; Lipid Peroxidation; Magnetic Resonance Spectroscopy; Maillard Reaction; Phenylalanine; Thiazoles | 2004 |
Controlling {beta}-amyloid oligomerization by the use of naphthalene sulfonates: trapping low molecular weight oligomeric species.
Topics: Amyloid; Amyloid beta-Peptides; Anilino Naphthalenesulfonates; Animals; Anions; Benzothiazoles; Biochemistry; Cell Line; Chromatography; Congo Red; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Fluorescent Dyes; Hydrogen-Ion Concentration; Kinetics; Light; Lysine; Magnetic Resonance Spectroscopy; Mice; Micelles; Models, Chemical; Models, Molecular; Molecular Conformation; Molecular Weight; Naphthalenesulfonates; Peptide Fragments; Peptides; Phenylalanine; Prions; Protein Structure, Secondary; Scattering, Radiation; Sodium Dodecyl Sulfate; Spectrophotometry; Static Electricity; Sulfonic Acids; Temperature; Tetrazolium Salts; Thiazoles; Time Factors | 2005 |
Effects of the sequence and size of non-polar residues on self-assembly of amphiphilic peptides.
Topics: Alanine; Amino Acid Motifs; Amyloid; Benzothiazoles; Circular Dichroism; Congo Red; Gene Library; Glycine; Hydrogel, Polyethylene Glycol Dimethacrylate; Isoleucine; Leucine; Macromolecular Substances; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Models, Molecular; Peptides; Phenylalanine; Protein Binding; Protein Conformation; Protein Folding; Protein Structure, Secondary; Temperature; Thiazoles; Ultraviolet Rays; Valine; X-Ray Diffraction | 2005 |
Assessing the role of aromatic residues in the amyloid aggregation of human muscle acylphosphatase.
Topics: Acid Anhydride Hydrolases; Acylphosphatase; Amino Acid Substitution; Amyloid; Benzothiazoles; Birefringence; Circular Dichroism; Congo Red; Data Interpretation, Statistical; Humans; Hydrophobic and Hydrophilic Interactions; Muscles; Phase Transition; Phenylalanine; Protein Structure, Secondary; Spectroscopy, Fourier Transform Infrared; Thiazoles; Trifluoroethanol; Tyrosine | 2006 |
Aromatic interactions with phenylalanine 691 and cysteine 828: a concept for FMS-like tyrosine kinase-3 inhibition. Application to the discovery of a new class of potential antileukemia agents.
Topics: Acute Disease; Adenosine Triphosphate; Antineoplastic Agents; Binding Sites; Cell Line, Tumor; Cysteine; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid; Models, Molecular; Mutation; Phenylalanine; Protein Structure, Tertiary; Thiazoles | 2006 |
Presence or the emergence of a F317L BCR-ABL mutation may be associated with resistance to dasatinib in Philadelphia chromosome-positive leukemia.
Topics: Adult; Antineoplastic Agents; Blast Crisis; Clinical Trials, Phase II as Topic; Dasatinib; Disease Progression; Drug Resistance, Neoplasm; Female; Genes, abl; Humans; Leucine; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Mutation; Phenylalanine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Thiazoles; Treatment Failure | 2006 |
MAO-A-induced mitogenic signaling is mediated by reactive oxygen species, MMP-2, and the sphingolipid pathway.
Topics: Animals; Biogenic Amines; Blood Vessels; Butylated Hydroxytoluene; Cell Proliferation; Free Radical Scavengers; Hydrogen Peroxide; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Mice; Mice, Mutant Strains; Mitogens; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Myocytes, Smooth Muscle; Oxidation-Reduction; Pargyline; Phenylalanine; Rabbits; Reactive Oxygen Species; RNA, Small Interfering; Serotonin; Signal Transduction; Sphingolipids; Thiazoles; Thiophenes; Tyramine | 2007 |
Total synthesis of thiopeptide antibiotics GE2270A, GE2270T, and GE2270C1.
Topics: Acetamides; Anti-Bacterial Agents; Azoles; Hydroxylation; Macrolides; Molecular Structure; Peptides, Cyclic; Phenylalanine; Pyridines; Sulfhydryl Compounds; Thiazoles | 2008 |
The fluorescent amino acid p-cyanophenylalanine provides an intrinsic probe of amyloid formation.
Topics: Alanine; Amino Acid Sequence; Amyloid; Benzothiazoles; Diabetes Mellitus, Type 2; Fluorescence; Fluorescent Dyes; Humans; Islet Amyloid Polypeptide; Kinetics; Molecular Sequence Data; Nitriles; Phenylalanine; Point Mutation; Protein Binding; Thiazoles; Time Factors | 2008 |
Evidence for novel beta-sheet structures in Iowa mutant beta-amyloid fibrils.
Topics: Amyloid; Amyloid beta-Peptides; Amyloid Neuropathies, Familial; Aspartic Acid; Benzothiazoles; Glutamic Acid; Humans; Kinetics; Leucine; Lysine; Microscopy, Electron, Transmission; Models, Molecular; Mutation, Missense; Nuclear Magnetic Resonance, Biomolecular; Peptide Fragments; Phenylalanine; Protein Structure, Secondary; Spectrometry, Fluorescence; Thiazoles; X-Ray Diffraction | 2009 |
Major molecular response achieved with dasatinib in a CML patient with F317L BCR-ABL kinase domain mutation.
Topics: Amino Acid Substitution; Antineoplastic Agents; Cytogenetic Analysis; Dasatinib; Drug Resistance, Neoplasm; Humans; Leucine; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Phenylalanine; Protein Structure, Tertiary; Proto-Oncogene Proteins c-bcr; Pyrimidines; Thiazoles; Treatment Outcome | 2010 |
Dura in the pathogenesis of syndromic craniosynostosis: fibroblast growth factor receptor 2 mutations in dural cells promote osteogenic proliferation and differentiation of osteoblasts.
Topics: Acrocephalosyndactylia; Adenoviridae; Alkaline Phosphatase; Animals; Arginine; Biomarkers; Cell Differentiation; Cell Proliferation; Cells, Cultured; Coculture Techniques; Coloring Agents; Core Binding Factor Alpha 1 Subunit; Craniofacial Dysostosis; Craniosynostoses; Cysteine; Dura Mater; Genetic Vectors; Mice; Osteoblasts; Osteogenesis; Osteopontin; Phenylalanine; Point Mutation; Receptor, Fibroblast Growth Factor, Type 2; Syndrome; Tetrazolium Salts; Thiazoles | 2010 |
Antimycobacterial activity of UDP-galactopyranose mutase inhibitors.
Topics: Anti-Bacterial Agents; Antitubercular Agents; Cell Line; Enzyme Inhibitors; Humans; Intramolecular Transferases; Macrophages; Microbial Sensitivity Tests; Models, Molecular; Mycobacterium; Mycobacterium bovis; Mycobacterium tuberculosis; Phenylalanine; Pyrazoles; Thiazoles | 2010 |
Durable molecular response despite F317L and E255K mutations: Successful treatment of chronic myeloid leukemia with sequential imatinib, nilotinib and dasatinib.
Topics: Adult; Amino Acid Substitution; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Biomarkers, Pharmacological; Biomarkers, Tumor; Dasatinib; Female; Fusion Proteins, bcr-abl; Glutamic Acid; Humans; Imatinib Mesylate; Leucine; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lysine; Mutation, Missense; Phenylalanine; Piperazines; Polymorphism, Single Nucleotide; Pyrimidines; Remission Induction; Thiazoles; Time Factors; Treatment Outcome | 2012 |
Mouse prion protein polymorphism Phe-108/Val-189 affects the kinetics of fibril formation and the response to seeding: evidence for a two-step nucleation polymerization mechanism.
Topics: Alleles; Animals; Benzothiazoles; Circular Dichroism; Dose-Response Relationship, Drug; Kinetics; Mice; Microscopy, Electron; Phenylalanine; Polymers; Polymorphism, Genetic; Prion Diseases; Prions; Protein Conformation; Recombinant Proteins; Thiazoles; Time Factors; Valine | 2013 |
The role of aromatic L-amino acid decarboxylase in bacillamide C biosynthesis by Bacillus atrophaeus C89.
Topics: Amino Acid Sequence; Animals; Aromatic-L-Amino-Acid Decarboxylases; Bacillus; Decarboxylation; Dysidea; Molecular Sequence Data; Peptide Synthases; Phenylalanine; Sequence Alignment; Thiazoles; Tryptamines; Tryptophan | 2013 |
Gold complexes inhibit the aggregation of prion neuropeptides.
Topics: Amino Acid Sequence; Cell Line, Tumor; Cell Survival; Gold; Humans; Molecular Sequence Data; Organometallic Compounds; Peptide Fragments; Phenylalanine; Prions; Protein Multimerization; Thiazoles | 2013 |
Membrane active phenylalanine conjugated lipophilic norspermidine derivatives with selective antibacterial activity.
Topics: Anti-Bacterial Agents; Bacterial Infections; beta-Lactams; Drug Design; Drug Resistance, Bacterial; Enterococcus faecium; Humans; Kinetics; Klebsiella pneumoniae; Methicillin-Resistant Staphylococcus aureus; Micelles; Microbial Sensitivity Tests; Molecular Conformation; Phenylalanine; Plasma; Serum; Spermidine; Tetrazolium Salts; Thiazoles; Vancomycin | 2014 |
Conformational transformation of ascidiacyclamide analogues induced by incorporating enantiomers of phenylalanine, 1-naphthylalanine or 2-naphthylalanine.
Topics: Alanine; Cell Survival; Crystallography, X-Ray; Cytotoxins; HL-60 Cells; Humans; Models, Molecular; Naphthalenes; Oxazoles; Peptides, Cyclic; Phenylalanine; Protein Conformation; Protein Folding; Stereoisomerism; Structure-Activity Relationship; Thiazoles | 2016 |
Correctors of the Major Cystic Fibrosis Mutant Interact through Membrane-Spanning Domains.
Topics: Aminopyridines; Benzamides; Benzodioxoles; Cell Line; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; HEK293 Cells; Humans; Mutation; Phenylalanine; Protein Structure, Tertiary; Thiazoles | 2018 |
NBD2 Is Required for the Rescue of Mutant F508del CFTR by a Thiazole-Based Molecule: A Class II Corrector for the Multi-Drug Therapy of Cystic Fibrosis.
Topics: Aminopyridines; Benzodioxoles; Cell Membrane; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Epithelial Cells; Gene Expression Regulation; HEK293 Cells; Humans; Mutant Proteins; Phenylalanine; Thiazoles | 2021 |
Macrocyclization of bioactive peptides with internal thiazole motifs
Topics: Catalysis; Palladium; Peptides; Phenylalanine; Thiazoles | 2022 |