phenylalanine and sepiapterin

phenylalanine has been researched along with sepiapterin in 7 studies

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19903 (42.86)18.7374
1990's1 (14.29)18.2507
2000's1 (14.29)29.6817
2010's1 (14.29)24.3611
2020's1 (14.29)2.80

Authors

AuthorsStudies
Bettoni, O; Bieri, J; Curtius, HC; Niederwieser, A; Schaub, J; Schircks, B; Viscontini, M1
Blaskovics, M; Blau, N; Curtius, HC; Giudici, T; Kierat, L1
Boudha, A; Dhondt, JL; Farriaux, JP; Largillière, C; Leeming, RJ; Ringel, J; Roger, MM1
Curtius, HC; Leupold, D; Niederwieser, A; Wang, M1
Bahrami, S; Heller, R; Werner, ER; Werner-Felmayer, G1
Lee, KH; Park, KH; Park, YS; Seo, KH; Zhuang, N1
Bratkovic, D; Margvelashvili, L; Nisbet, J; Smith, N; Tchan, MC1

Trials

1 trial(s) available for phenylalanine and sepiapterin

ArticleYear
PTC923 (sepiapterin) lowers elevated blood phenylalanine in subjects with phenylketonuria: a phase 2 randomized, multi-center, three-period crossover, open-label, active controlled, all-comers study.
    Metabolism: clinical and experimental, 2022, Volume: 128

    Topics: Adolescent; Adult; Biopterins; Cross-Over Studies; Female; Humans; Male; Phenylalanine; Phenylketonurias; Pterins; Young Adult

2022

Other Studies

6 other study(ies) available for phenylalanine and sepiapterin

ArticleYear
Atypical phenylketonuria caused by 7, 8-dihydrobiopterin synthetase deficiency.
    Lancet (London, England), 1979, Jan-20, Volume: 1, Issue:8108

    Topics: Alcohol Oxidoreductases; Biopterins; Child, Preschool; Female; Guanosine Triphosphate; Humans; Phenylalanine; Phenylketonurias; Pteridines; Pterins

1979
Hyperphenylalaninaemia presumably due to carbinolamine dehydratase deficiency: loading tests with pterin derivatives.
    Journal of inherited metabolic disease, 1992, Volume: 15, Issue:3

    Topics: Biopterins; Female; Humans; Hydro-Lyases; Infant, Newborn; Kinetics; Phenylalanine; Pteridines; Pterins

1992
Neonatal hyperphenylalaninemia presumably caused by guanosine triphosphate-cyclohydrolase deficiency.
    The Journal of pediatrics, 1985, Volume: 106, Issue:6

    Topics: Aminohydrolases; Biopterins; GTP Cyclohydrolase; Humans; Infant, Newborn; Leukocyte Count; Liver; Male; Neopterin; Phenylalanine; Pteridines; Pterins; T-Lymphocytes

1985
Atypical phenylketonuria with defective biopterin metabolism. Monotherapy with tetrahydrobiopterin or sepiapterin, screening and study of biosynthesis in man.
    European journal of pediatrics, 1982, Volume: 138, Issue:2

    Topics: Biopterins; Child, Preschool; Female; Humans; Neopterin; Phenylalanine; Phenylketonurias; Pteridines; Pterins; Serotonin

1982
Bacterial lipopolysaccharide down-regulates expression of GTP cyclohydrolase I feedback regulatory protein.
    The Journal of biological chemistry, 2002, Mar-22, Volume: 277, Issue:12

    Topics: Alanine; Blotting, Northern; Cells, Cultured; Cloning, Molecular; DNA, Complementary; Dose-Response Relationship, Drug; Down-Regulation; Endothelium, Vascular; GTP Cyclohydrolase; Humans; Interferon-gamma; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; Phenylalanine; Protein Binding; Proteins; Pteridines; Pterins; Recombinant Proteins; RNA, Messenger; Time Factors; Tissue Distribution; Tumor Cells, Cultured; Umbilical Veins; Up-Regulation

2002
Structural basis of a novel activity of bacterial 6-pyruvoyltetrahydropterin synthase homologues distinct from mammalian 6-pyruvoyltetrahydropterin synthase activity.
    Acta crystallographica. Section D, Biological crystallography, 2014, Volume: 70, Issue:Pt 5

    Topics: Amino Acid Sequence; Animals; Bacterial Proteins; Binding Sites; Catalytic Domain; Crystallography, X-Ray; Escherichia coli Proteins; Mammals; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Phenylalanine; Phosphorus-Oxygen Lyases; Phylogeny; Protein Conformation; Pterins; Sequence Homology, Amino Acid

2014