phenylalanine has been researched along with rb 101 in 55 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 34 (61.82) | 18.2507 |
| 2000's | 19 (34.55) | 29.6817 |
| 2010's | 1 (1.82) | 24.3611 |
| 2020's | 1 (1.82) | 2.80 |
| Authors | Studies |
|---|---|
| Baamonde, A; Fournie-Zaluski, MC; Roques, BP; Ruiz-Gayo, M; Turcaud, S | 1 |
| Baamonde, A; Daugé, V; Fournié-Zaluski, MC; Fulga, IG; Roques, BP; Ruiz-Gayo, M; Turcaud, S | 1 |
| Durieux, C; Fournié-Zaluski, MC; Roques, BP; Ruiz-Gayo, M | 1 |
| Fournié-Zaluski, MC; Noble, F; Roques, BP; Turcaud, S | 1 |
| Coric, P; Fournié-Zaluski, MC; Noble, F; Roques, BP | 1 |
| Fournie-Zaluski, MC; Noble, F; Roques, BP; Soleilhac, JM; Soroca-Lucas, E; Turcaud, S | 1 |
| Blommaert, A; Fournié-Zaluski, MC; Noble, F; Roques, BP | 1 |
| Corringer, PJ; Dauge, V; Roques, BP | 1 |
| Blommaert, AG; Ducos, B; Fournie-Zaluski, MC; Maldonado, R; Roques, BP; Valverde, O | 1 |
| Fournié-Zaluski, MC; Noble, F; Roques, BP | 2 |
| Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Turcaud, S; Valverde, O | 1 |
| Noble, F; Roques, BP; Smadja, C | 1 |
| Fournie-Zaluski, MC; Maldonado, R; Roques, BP; Valverde, O | 2 |
| Abbadie, C; Besson, JM; Fournié-Zaluski, MC; Honoré, P; Roques, BP | 1 |
| Coric, P; Fournié-Zaluski, MC; Noble, F; Roques, BP; Turcaud, S | 1 |
| Derrien, M; Maldonado, R; Noble, F; Roques, BP | 1 |
| Derrien, M; Noble, F; Roques, BP | 1 |
| Fournie-Zaluski, MC; Maldonado, R; Roques, BP; Smadja, C; Turcaud, S | 1 |
| Blommaert, AG; Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Valverde, O | 1 |
| Cesselin, F; Daugé, V; Fournié-Zaluski, MC; Mauborgne, A; Roques, BP | 1 |
| Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Ruiz, F | 1 |
| Krylatov, AV; Lishmanov, IuB; Maslov, LN; Uskina, EV | 1 |
| Fournié-Zaluski, MC; Fuentes, JA; Hernando, F; Roques, BP; Ruiz-Gayo, M | 1 |
| Carp, HM; Fournié-Zaluski, MC; Jayaram, A; Noreuil, T; Singh, P | 1 |
| Besson, JM; Buritova, J; Fournié-Zaluski, MC; Honore, P; Roques, BP | 1 |
| Elfvin, A; Fournié-Zaluski, MC; Hao, JX; Roques, BP; Wiesenfeld-Hallin, Z; Xu, XJ | 1 |
| Borrelli, E; Maldonado, R; Roques, BP; Saiardi, A; Samad, TA; Valverde, O | 1 |
| Coric, P; Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Ruiz, F; Smadja, C | 1 |
| Liupina, IuV; Maldonado, R; Medvedeva, OF; Sudakov, SK; Tiurina, IV | 1 |
| Gilbert-Rahola, J; Maldonado, R; Micó, JA; Roques, BP; Smadja, C; Tejedor-Real, P | 1 |
| Chover-Gonzalez, AJ; Fournié-Zaluski, MC; Gibert-Rahola, J; Lai-Kuen, R; Maldonado, R; Mico, JA; Ortega-Alvaro, A; Roques, BP | 1 |
| Besson, JM; Catheline, G; Fournié-Zaluski, MC; Honoré, P; Le Guen, S; Roques, BP | 1 |
| Boudinot, E; Denavit-Saubié, M; Fournié-Zaluski, M; Foutz, AS; Morin-Surun, M; Roques, BP | 1 |
| Boucher, M; Coudoré-Civiale, MA; Eschalier, A; Fournié-Zaluski, MC; Méen, M; Roques, BP | 1 |
| Beslot, F; Daugé, V; Fournié-Zaluski, MC; Noble, F; Roques, BP; Valverde, O | 1 |
| Benavides, J; Fournié-Zaluski, MC; Nieto, MM; Noble, F; Roques, BP; Walker, J; Wilson, J | 1 |
| Ackermann, J; Assmann, I; Drach, J; Hübl, W; Ludwig, H; Schuster-Kolbe, J; Strasser, K; Zojer, N | 1 |
| Besson, JM; Buritova, J; Fournié-Zaluski, MC; Le Guen, S; Noble, F; Roques, BP | 1 |
| Benoist, JM; Fournié-Zaluski, MC; Keime, F; Le Bars, D; Montagne, J; Noble, F; Roques, BP; Willer, JC | 1 |
| Besson, JM; Buritova, J; Catheline, G; Fournié-Zaluski, MC; Le Guen, S; Roques, BP | 1 |
| Besson, JM; Buritova, J; Fournié-Zaluski, MC; Le Guen, S; Roques, BP | 1 |
| Cordonnier, L; Noble, F; Roques, BP; Sanchez, M | 2 |
| Guen, SL; Kieffer, BL; Nieto, MM; Noble, F; Roques, BP | 1 |
| Canestrelli, C; Crété, D; Jardinaud, F; Ledent, C; Noble, F; Roques, BP | 1 |
| McNally, GP | 1 |
| Folk, JE; Jutkiewicz, EM; Mosberg, HI; Rice, KC; Sobczyk-Kojiro, K; Torregrossa, MM; Watson, SJ; Woods, JH | 1 |
| Bilkei-Gorzo, A; Michel, K; Noble, F; Roques, BP; Zimmer, A | 1 |
| Jutkiewicz, EM | 1 |
| Benturquia, N; Bilkei-Gorzo, A; Noble, F; Roques, BP; Zimmer, A | 1 |
| Cabañero, D; Célérier, E; García-Nogales, P; Maldonado, R; Mata, M; Puig, MM; Roques, BP | 1 |
| Hurlé, MA; Lantero, A; Pílar-Cuellar, F; Roques, BP; Santillán, R; Tramullas, M; Valdizán, E | 1 |
| Bansal, N; Fonseca, A; Gillis, J; Gulati, A; Horine, SV; Kuppalli, S; Mendelson, A; Southerland, WA | 1 |
2 review(s) available for phenylalanine and rb 101
| Article | Year |
|---|---|
RB101-mediated protection of endogenous opioids: potential therapeutic utility?
Topics: Aminopeptidases; Animals; Cholecystokinin; Disulfides; Enkephalin, Leucine; Enkephalin, Methionine; Enzyme Inhibitors; Mice; Phenylalanine; Prodrugs; Rats | 2007 |
Dual Enkephalinase Inhibitors and Their Role in Chronic Pain Management.
Topics: CD13 Antigens; Chronic Pain; Dipeptides; Disulfides; Enkephalins; Enzyme Inhibitors; Humans; Neprilysin; Phenylalanine; Propionates; Propylamines | 2021 |
53 other study(ies) available for phenylalanine and rb 101
| Article | Year |
|---|---|
In vivo occupation of mouse brain opioid receptors by endogenous enkephalins: blockade of enkephalin degrading enzymes by RB 101 inhibits [3H]diprenorphine binding.
Topics: Analgesics; Animals; Brain; Cell Membrane; Diprenorphine; Disulfides; Enkephalins; Hot Temperature; Kinetics; Male; Mice; Mice, Inbred Strains; Neprilysin; Pain; Phenylalanine; Receptors, Opioid; Stress, Psychological; Tritium | 1992 |
Antidepressant-type effects of endogenous enkephalins protected by systemic RB 101 are mediated by opioid delta and dopamine D1 receptor stimulation.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Conditioning, Operant; Disulfides; Dopamine; Enkephalins; Male; Mice; Motor Activity; Phenylalanine; Prodrugs; Receptors, Dopamine D1; Receptors, Opioid, delta; Swimming | 1992 |
Stimulation of delta-opioid receptors reduces the in vivo binding of the cholecystokinin (CCK)-B-selective agonist [3H]pBC 264: evidence for a physiological regulation of CCKergic systems by endogenous enkephalins.
Topics: Analgesics; Analgesics, Opioid; Animals; Cholecystokinin; Dipeptides; Disulfides; Dose-Response Relationship, Drug; Enkephalins; Male; Mice; Narcotic Antagonists; Peptide Fragments; Phenylalanine; Prodrugs; Receptors, Cholecystokinin; Receptors, Opioid | 1992 |
Repeated systemic administration of the mixed inhibitor of enkephalin-degrading enzymes, RB101, does not induce either antinociceptive tolerance or cross-tolerance with morphine.
Topics: Analgesics; Animals; Disulfides; Dose-Response Relationship, Drug; Drug Tolerance; Indoles; Male; Mice; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Phenylalanine; Prodrugs; Reaction Time | 1992 |
Lack of physical dependence in mice after repeated systemic administration of the mixed inhibitor prodrug of enkephalin-degrading enzymes, RB101.
Topics: Animals; Behavior, Animal; Body Weight; Disulfides; Injections, Intraventricular; Male; Mice; Morphine; Naloxone; Phenylalanine; Prodrugs; Substance Withdrawal Syndrome; Substance-Related Disorders | 1992 |
Inhibition of the enkephalin-metabolizing enzymes by the first systemically active mixed inhibitor prodrug RB 101 induces potent analgesic responses in mice and rats.
Topics: Aminopeptidases; Analgesia; Analgesics; Animals; Cell Membrane; Chromatography, High Pressure Liquid; Disulfides; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Inhibitors; Injections, Intravenous; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Naloxone; Neprilysin; Phenylalanine; Prodrugs; Rats; Rats, Inbred Strains | 1992 |
A selective CCKB receptor antagonist potentiates, mu-, but not delta-opioid receptor-mediated antinociception in the formalin test.
Topics: Analgesics; Animals; Disulfides; Enkephalins; Formaldehyde; Indoles; Male; Meglumine; Mice; Morphine; Naloxone; Naltrexone; Pain Measurement; Phenylalanine; Receptors, Cholecystokinin; Receptors, Opioid, delta; Receptors, Opioid, mu | 1995 |
CCKA, but not CCKB, agonists suppress the hyperlocomotion induced by endogenous enkephalins, protected from enzymatic degradation by systemic RB 101.
Topics: Amino Acid Sequence; Animals; Benzodiazepinones; Cholecystokinin; Devazepide; Disulfides; Enkephalins; Enzyme Inhibitors; Male; Mice; Molecular Sequence Data; Motor Activity; Naltrexone; Narcotic Antagonists; Peptide Fragments; Phenylalanine; Receptors, Cholecystokinin | 1995 |
Inhibition of morphine withdrawal by the association of RB 101, an inhibitor of enkephalin catabolism, and the CCKB antagonist PD-134,308.
Topics: Analgesics; Animals; Behavior, Animal; Binding, Competitive; Body Temperature; Diprenorphine; Disulfides; Drug Combinations; Drug Synergism; Enkephalins; Indoles; Male; Meglumine; Mice; Morphine; Motor Activity; Naloxone; Phenylalanine; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Substance Withdrawal Syndrome; Weight Loss | 1995 |
Paradoxical analgesia induced by low doses of naloxone is not potentiated by complete inhibition of enkephalin degradation.
Topics: Abdominal Muscles; Aminopeptidases; Analgesics; Animals; CD13 Antigens; Disulfides; Enkephalins; Male; Mice; Naloxone; Neprilysin; Pain Measurement; Phenylalanine | 1994 |
Antinociceptive response induced by mixed inhibitors of enkephalin catabolism in peripheral inflammation.
Topics: Analgesics; Animals; Disulfides; Enkephalins; Hydroxamic Acids; Inflammation; Injections, Intraventricular; Male; Morphine; Naloxone; Narcotic Antagonists; Neprilysin; Pain; Pain Measurement; Phenylalanine; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley | 1994 |
Role of endogenous cholecystokinin in the facilitation of mu-mediated antinociception by delta-opioid agonists.
Topics: Amino Acid Sequence; Analgesia; Animals; Benzodiazepinones; Cholecystokinin; Devazepide; Disulfides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Molecular Sequence Data; Naloxone; Naltrexone; Oligopeptides; Peptide Fragments; Phenylalanine; Receptors, Opioid, delta; Receptors, Opioid, mu; Sincalide | 1994 |
Cholecystokinin B antagonists strongly potentiate antinociception mediated by endogenous enkephalins.
Topics: Adamantane; Analgesics; Animals; Benzodiazepinones; Dipeptides; Disulfides; Drug Synergism; Enkephalins; Indoles; Male; Meglumine; Nociceptors; Pain Measurement; Phenylalanine; Phenylurea Compounds; Prodrugs; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Regression Analysis; Tail | 1994 |
Effects of opioids and non-opioids on c-Fos-like immunoreactivity induced in rat lumbar spinal cord neurons by noxious heat stimulation.
Topics: Analgesia; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disulfides; Drug Interactions; Drug Tolerance; Hot Temperature; Immunohistochemistry; Injections, Intravenous; Male; Morphine; Neurons; Phenylalanine; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Cord | 1994 |
Assessment of physical dependence after continuous perfusion into the rat jugular vein of the mixed inhibitor of enkephalin-degrading enzymes, RB 101.
Topics: Analgesics; Animals; Behavior, Animal; Catheterization, Central Venous; Disulfides; Enzyme Inhibitors; Injections, Subcutaneous; Male; Morphine Dependence; Naloxone; Phenylalanine; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Substance-Related Disorders | 1994 |
Association of the peptidase inhibitor RB 101 and a CCK-B antagonist strongly enhances antinociceptive responses.
Topics: Analgesics; Animals; Benzodiazepinones; Cholecystokinin; Devazepide; Disulfides; Drug Synergism; Male; Mice; Pain Measurement; Phenylalanine; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Cholecystokinin | 1993 |
Modulation of opioid antinociception by CCK at the supraspinal level: evidence of regulatory mechanisms between CCK and enkephalin systems in the control of pain.
Topics: Amino Acid Sequence; Analgesics; Animals; Cholecystokinin; Disulfides; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Molecular Sequence Data; Oligopeptides; Pain; Pain Measurement; Peptide Fragments; Phenylalanine; Sincalide; Spinal Cord | 1993 |
Unlike morphine the endogenous enkephalins protected by RB101 are unable to establish a conditioned place preference in mice.
Topics: Animals; Conditioning, Operant; Disulfides; Drug Interactions; Enkephalins; Enzyme Inhibitors; Male; Mice; Morphine; Naloxone; Phenylalanine; Prodrugs; Substance-Related Disorders | 1993 |
Opposite role of CCKA and CCKB receptors in the modulation of endogenous enkephalin antidepressant-like effects.
Topics: Analgesics; Animals; Antidepressive Agents; Benzodiazepinones; Cholecystokinin; Disulfides; Enkephalins; Male; Mice; Mice, Inbred Strains; Motor Activity; Peptide Fragments; Phenylalanine; Phenylurea Compounds; Receptors, Cholecystokinin | 1995 |
Weak tolerance to the antinociceptive effect induced by the association of a peptidase inhibitor and a CCKB receptor antagonist.
Topics: Analgesics; Animals; Benzodiazepinones; Disulfides; Drug Synergism; Drug Tolerance; Indoles; Male; Meglumine; Mice; Pain Measurement; Phenylalanine; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Time Factors | 1995 |
The dual peptidase inhibitor RB101 induces a long-lasting increase in the extracellular level of Met-enkephalin-like material in the nucleus accumbens of freely moving rats.
Topics: Animals; Antibody Specificity; Chromatography, High Pressure Liquid; Disulfides; Enkephalin, Methionine; Enzyme Inhibitors; Extracellular Space; Male; Motor Activity; Nucleus Accumbens; Phenylalanine; Potassium Chloride; Radioimmunoassay; Rats; Rats, Wistar | 1996 |
Similar decrease in spontaneous morphine abstinence by methadone and RB 101, an inhibitor of enkephalin catabolism.
Topics: Analgesics; Animals; Disulfides; Drug Combinations; Enkephalins; Indoles; Male; Meglumine; Methadone; Morphine; Naloxone; Phenylalanine; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Substance Withdrawal Syndrome | 1996 |
Similar involvement of several brain areas in the antinociception of endogenous and exogenous opioids.
Topics: Analgesia; Analgesics, Opioid; Animals; Brain; Disulfides; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; Opioid Peptides; Phenylalanine; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley | 1996 |
[Opiatergic mechanisms of antiarrhythmic effect of adaptation].
Topics: Adaptation, Physiological; Animals; Arrhythmias, Cardiac; Calcium Chloride; Disulfides; Endorphins; Enzyme Inhibitors; Epinephrine; Male; Naltrexone; Narcotic Antagonists; Neprilysin; Phenylalanine; Rats; Rats, Wistar; Receptors, Opioid | 1996 |
Antidepressant-like effects of CCK(B) receptor antagonists: involvement of the opioid system.
Topics: Animals; Antidepressive Agents; Benzodiazepinones; Devazepide; Disulfides; Endorphins; Male; Mice; Naloxone; Naltrexone; Phenylalanine; Phenylurea Compounds; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Sincalide | 1996 |
RB 101, a purported pro drug inhibitor of enkephalin metabolism, is antinociceptive in pregnant mice.
Topics: Analgesics; Analgesics, Opioid; Animals; Depression, Chemical; Disulfides; Enkephalins; Female; Mice; Morphine; Naloxone; Narcotic Antagonists; Pain Threshold; Phenylalanine; Pregnancy; Pregnancy, Animal; Prodrugs; Respiration | 1997 |
Antinociceptive effects of RB101, a complete inhibitor of enkephalin-catabolizing enzymes, are enhanced by a cholecystokinin type B receptor antagonist, as revealed by noxiously evoked spinal c-Fos expression in rats.
Topics: Analgesics; Animals; Benzodiazepinones; Devazepide; Disulfides; Dose-Response Relationship, Drug; Edema; Enzyme Inhibitors; Indoles; Male; Meglumine; Pain; Phenylalanine; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Spinal Cord | 1997 |
CI 988, an antagonist of the cholecystokinin-B receptor, potentiates endogenous opioid-mediated antinociception at spinal level.
Topics: Analgesics; Animals; Decerebrate State; Disulfides; Dose-Response Relationship, Drug; Drug Synergism; Female; Hormone Antagonists; Indoles; Injections, Intravenous; Meglumine; Nociceptors; Opioid Peptides; Phenylalanine; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Reflex; Spinal Cord | 1997 |
Absence of opiate rewarding effects in mice lacking dopamine D2 receptors.
Topics: Animals; Behavior, Addictive; Blotting, Northern; Disulfides; Enzyme Inhibitors; Locomotion; Mice; Morphine; Phenylalanine; Receptors, Dopamine D2; Reward; Substance-Related Disorders | 1997 |
CCK-B receptors in the limbic system modulate the antidepressant-like effects induced by endogenous enkephalins.
Topics: Amygdala; Animals; Caudate Nucleus; Disulfides; Enkephalins; Enzyme Inhibitors; Hormone Antagonists; Indoles; Injections, Intraventricular; Limbic System; Male; Meglumine; Mice; Motor Activity; Neprilysin; Nucleus Accumbens; Phenylalanine; Rats; Rats, Wistar; Receptor, Cholecystokinin B; Receptors, Cholecystokinin | 1997 |
[Characteristics of effects of mu-, delta-, and kappa-opioid agonists and enkephalinase inhibitor RB101 in rats of two inbred strains].
Topics: Analgesics; Animals; Depression, Chemical; Disulfides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Inhibitors; Male; Motor Activity; Neprilysin; Oligopeptides; Pain Measurement; Peptides; Phenylalanine; Rats; Rats, Inbred F344; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1998 |
Involvement of delta-opioid receptors in the effects induced by endogenous enkephalins on learned helplessness model.
Topics: Analgesics; Animals; Behavior, Animal; Disulfides; Drug Interactions; Enkephalins; Helplessness, Learned; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Phenylalanine; Rats; Rats, Wistar; Receptors, Opioid, delta | 1998 |
Antinociception produced by the peptidase inhibitor, RB 101, in rats with adrenal medullary transplant into the spinal cord.
Topics: Adrenal Medulla; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Disulfides; Injections, Intravenous; Male; Naloxone; Narcotic Antagonists; Pain; Phentolamine; Phenylalanine; Protease Inhibitors; Rats; Rats, Wistar; Spinal Cord; Subarachnoid Space; Transplantation, Autologous | 1998 |
The effects of RB101, a mixed inhibitor of enkephalin-catabolizing enzymes, on carrageenin-induced spinal c-Fos expression are completely blocked by beta-funaltrexamine, a selective mu-opioid receptor antagonist.
Topics: Animals; Carrageenan; Disulfides; Enzyme Inhibitors; Male; Naltrexone; Narcotic Antagonists; Neprilysin; Phenylalanine; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spinal Cord | 1999 |
Effects of the potent analgesic enkephalin-catabolizing enzyme inhibitors RB101 and kelatorphan on respiration.
Topics: Analgesics; Animals; Cats; Dipeptides; Disulfides; Enkephalins; Enzyme Inhibitors; Mice; Naloxone; Narcotic Antagonists; Phenylalanine; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Respiration | 2001 |
Enhancement of the effects of a complete inhibitor of enkephalin-catabolizing enzymes, RB 101, by a cholecystokinin-B receptor antagonist in diabetic rats.
Topics: Aminopeptidases; Animals; Diabetes Mellitus, Experimental; Disulfides; Drug Synergism; Indoles; Male; Meglumine; Naloxone; Naltrexone; Neprilysin; Pain; Pain Measurement; Phenylalanine; Pressure; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Time Factors; Vocalization, Animal; Weight Loss | 2001 |
Delta9-tetrahydrocannabinol releases and facilitates the effects of endogenous enkephalins: reduction in morphine withdrawal syndrome without change in rewarding effect.
Topics: Analgesics; Animals; Binding, Competitive; Conditioning, Psychological; Diprenorphine; Disulfides; Dronabinol; Drug Interactions; Enkephalin, Methionine; Extracellular Space; Male; Mice; Morphine; Motor Activity; Narcotic Antagonists; Narcotics; Neurons; Nociceptors; Nucleus Accumbens; Phenylalanine; Psychotropic Drugs; Reward; Substance Withdrawal Syndrome; Tritium | 2001 |
Facilitation of enkephalins catabolism inhibitor-induced antinociception by drugs classically used in pain management.
Topics: Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Disulfides; Enkephalins; Enzyme Inhibitors; Formaldehyde; Injections, Intravenous; Injections, Subcutaneous; Male; Mice; Morphine; Neprilysin; Pain; Pain Measurement; Phenylalanine; Pressure; Rats; Rats, Sprague-Dawley; Reaction Time | 2001 |
Chromosomal aberrations are shared by malignant plasma cells and a small fraction of circulating CD19+ cells in patients with myeloma and monoclonal gammopathy of undetermined significance.
Topics: Aged; Aged, 80 and over; Antigens, CD19; Bone Marrow Examination; Chromosome Aberrations; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 17; Clone Cells; Disease Progression; Disulfides; Gene Deletion; Genes, Immunoglobulin; Genes, p53; Genes, Retinoblastoma; Humans; Immunoglobulin G; Immunoglobulin Light Chains; Immunohistochemistry; In Situ Hybridization, Fluorescence; Membrane Glycoproteins; Middle Aged; Multiple Myeloma; Paraproteinemias; Phenylalanine; Plasma Cells; Polymerase Chain Reaction; Proteoglycans; RNA, Messenger; Syndecan-1; Syndecans; T-Lymphocytes | 2002 |
RB101(S), a dual inhibitor of enkephalinases does not induce antinociceptive tolerance, or cross-tolerance with morphine: a c-Fos study at the spinal level.
Topics: Analgesics; Animals; Disulfides; Drug Tolerance; Enkephalins; Enzyme Inhibitors; Male; Morphine; Phenylalanine; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Cord | 2002 |
Depressant effect on a C-fibre reflex in the rat, of RB101, a dual inhibitor of enkephalin-degrading enzymes.
Topics: Aminopeptidases; Animals; CD13 Antigens; Disulfides; Dose-Response Relationship, Drug; Electric Stimulation; Male; Neprilysin; Nerve Fibers, Unmyelinated; Phenylalanine; Rats; Rats, Sprague-Dawley; Reflex | 2002 |
Further evidence for the interaction of mu- and delta-opioid receptors in the antinociceptive effects of the dual inhibitor of enkephalin catabolism, RB101(S). A spinal c-Fos protein study in the rat under carrageenin inflammation.
Topics: Analgesics; Animals; Carrageenan; Disulfides; Edema; Enkephalins; Gene Expression Regulation; Inflammation; Male; Phenylalanine; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 2003 |
Antinociceptive effects of RB101(S), a complete inhibitor of enkephalin-catabolizing enzymes, are enhanced by (+)-HA966, a functional NMDA receptor antagonist: a c-Fos study in the rat spinal cord.
Topics: Analgesics; Animals; Carrageenan; Disulfides; Drug Therapy, Combination; Enkephalins; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Immunohistochemistry; Inflammation; Male; Naloxone; Narcotic Antagonists; Pain; Phenylalanine; Proto-Oncogene Proteins c-fos; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 2003 |
Facilitation of enkephalins-induced delta-opioid behavioral responses by chronic amisulpride treatment.
Topics: Amisulpride; Animals; Behavior, Animal; Disulfides; Dopamine Antagonists; Enkephalins; Male; Mice; Motor Activity; Naloxone; Narcotic Antagonists; Pain Measurement; Phenylalanine; Reaction Time; Receptors, Opioid, delta; Sulpiride; Swimming | 2005 |
Physiological control of emotion-related behaviors by endogenous enkephalins involves essentially the delta opioid receptors.
Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Disulfides; Dose-Response Relationship, Drug; Drug Interactions; Emotions; Enkephalins; Enzyme Inhibitors; Exploratory Behavior; Freezing Reaction, Cataleptic; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Phenylalanine; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, mu; Swimming; Time Factors | 2005 |
CB1 receptor knockout mice show similar behavioral modifications to wild-type mice when enkephalin catabolism is inhibited.
Topics: Analysis of Variance; Animals; Anxiety; Disulfides; Dose-Response Relationship, Drug; Enkephalins; Enzyme Inhibitors; Female; Immobility Response, Tonic; Male; Mice; Mice, Knockout; Motor Activity; Pain Threshold; Phenylalanine; Receptor, Cannabinoid, CB1 | 2005 |
Facilitation of fear extinction by midbrain periaqueductal gray infusions of RB101(S), an inhibitor of enkephalin-degrading enzymes.
Topics: Animals; Behavior, Animal; Conditioning, Classical; Disulfides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extinction, Psychological; Fear; Male; Periaqueductal Gray; Phenylalanine; Rats; Rats, Wistar; Time Factors | 2005 |
Behavioral and neurobiological effects of the enkephalinase inhibitor RB101 relative to its antidepressant effects.
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Behavior, Animal; Benzamides; Brain-Derived Neurotrophic Factor; Disulfides; Dose-Response Relationship, Drug; Electroencephalography; Enzyme Inhibitors; Frontal Lobe; Hippocampus; Injections, Intravenous; Male; Motor Activity; Naltrexone; Narcotic Antagonists; Neprilysin; Phenylalanine; Piperazines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Swimming | 2006 |
Blockade of morphine-induced behavioral sensitization by a combination of amisulpride and RB101, comparison with classical opioid maintenance treatments.
Topics: Amisulpride; Animals; Behavior, Animal; Buprenorphine; Disulfides; Male; Methadone; Mice; Morphine; Motor Activity; Opioid-Related Disorders; Phenylalanine; Sulpiride | 2007 |
Preproenkephalin knockout mice show no depression-related phenotype.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Disulfides; Dose-Response Relationship, Drug; Enkephalins; Enzyme Inhibitors; Hindlimb Suspension; Immobility Response, Tonic; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Motor Activity; Nialamide; Phenotype; Phenylalanine; Protein Precursors; Swimming; Vocalization, Animal | 2007 |
Use of preproenkephalin knockout mice and selective inhibitors of enkephalinases to investigate the role of enkephalins in various behaviours.
Topics: Analysis of Variance; Animals; Behavior, Animal; CD13 Antigens; Disulfides; Dose-Response Relationship, Drug; Enkephalins; Enzyme Inhibitors; Injections, Intravenous; Mice; Mice, Inbred DBA; Mice, Knockout; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Neprilysin; Phenylalanine; Protein Precursors; Swimming | 2008 |
The pro-nociceptive effects of remifentanil or surgical injury in mice are associated with a decrease in delta-opioid receptor mRNA levels: Prevention of the nociceptive response by on-site delivery of enkephalins.
Topics: Analgesics; Animals; Disease Models, Animal; Disulfides; Down-Regulation; Enkephalins; Ganglia, Spinal; Male; Methyl Ethers; Mice; Pain Measurement; Pain Threshold; Pain, Postoperative; Phenylalanine; Piperidines; Protein Precursors; Receptors, Opioid, delta; Receptors, Opioid, mu; Remifentanil; RNA, Messenger; Sevoflurane; Spinal Cord; Time Factors | 2009 |
TGF-β and opioid receptor signaling crosstalk results in improvement of endogenous and exogenous opioid analgesia under pathological pain conditions.
Topics: Adenylyl Cyclase Inhibitors; Analgesia; Analgesics, Opioid; Animals; Disulfides; Hyperalgesia; Infusions, Subcutaneous; Membrane Proteins; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Neuralgia; Peripheral Nerve Injuries; Phenylalanine; Receptors, Opioid, delta; Receptors, Opioid, mu; Sciatic Nerve; Signal Transduction; Spinal Cord; Transforming Growth Factor beta | 2014 |