phenylalanine and piperidines

phenylalanine has been researched along with piperidines in 113 studies

Research

Studies (113)

Timeframe	Studies, this research(%)	All Research%
pre-1990	10 (8.85)	18.7374
1990's	17 (15.04)	18.2507
2000's	56 (49.56)	29.6817
2010's	24 (21.24)	24.3611
2020's	6 (5.31)	2.80

Authors

Authors	Studies
Ajisaka, K; Nakagomi, K; Yokota, I	1
Ajisaka, K; Nakagomi, K	1
Buffet, E; Droulle, C; Lafaurie, M; Potron, G; Rémy, MG	1
Hauptmann, J; Kaiser, B; Paintz, M; Richter, M	1
Gustafson, GT; Lerner, UH	1
Burguillo, FJ; Del Arco, A; Izquierdo, C; Usero, JL	1
Boyd, JE; Sommerville, RG	1
Aceto, MD; Brown, TG; Harris, LS; Lesher, GY; Pearl, J	1
Leonard, BE; Tonge, SR	1
Hadwiger, LA	1
Christensen, HN; Harrison, LI	1
Shioiri, T; Takusagawa, T; Yamada, SI	1
Bikker, J; Chung, FZ; Humblet, C; Lee, H; Pritchard, MC; Raphy, J; Suman-Chauhan, N; Tian, Y; Vartanian, MA; Wu, LH	1
Bakkali-Nadi, A; Malaisse, WJ; Malaisse-Lagae, F	1
Evans, H; Feldman, PA; McGrath, S	1
Brasseur, R; Lins, L; Malaisse, WJ	1
Malaisse, WJ	2
de Lima, ME; Diniz, CR; Magalhães, A; Zaganelli, GL; Zaganelli, MG	1
Bakkali Nadi, A; Malaisse, WJ; Zhang, TM	1
Kikuchi, M	2
Hauptmann, J; Prasa, D; Stürzebecher, J; Vieweg, H; Wikström, P	1
Fuhlendorff, J; Ladrière, L; Leclercq-Meyer, V; Malaisse, WJ	1
Alexopoulos, K; Holada, K; Matsoukas, J; Mavromoustakos, T; Roumelioti, P; Tselios, T	1
Dunning, BE; Hu, S; Wang, S	3
Smits, P; Tack, CJ	1
Bokvist, K; Buschard, K; Gromada, J; Holst, JJ; Hoy, M; Thomsen, MK	1
Bell, PA; Boettcher, BR; Dunning, BE; Fanelli, B; Geisse, S; Hu, S; Schmitz, R; Wang, S	1
Füchtenbusch, M; Schatz, H; Standl, E	1
Broxterman, HJ; Gebbink, MF; Hoekman, K; Jorna, AS; Pinedo, HM; Verheul, HM	1
Landgraf, R	1
Kalbag, JB; McLeod, JF; Nedelman, JR; Walter, YH	1
de Souza, CJ; Dunning, BE; Lozito, R; Russo, P	1
Dunning, BE; Foley, JE; Pratley, RE	1
Hu, S; Wang, S	1
Sternon, J	1
Dornhorst, A	1
Nelson, G	1
Koivisto, V	1
Hu, S	1
Ahmann, AJ; Riddle, MC	1
Barnes, TA; Calo, G; Guerrini, R; Lambert, DG; McDonald, J; Rowbotham, DJ	1
Bokvist, K; Gotfredsen, CF; Gromada, J; Hansen, BS; Høy, M; Lindström, P; Olsen, HL; Rorsman, P; Thomsen, MK	1
Ashcroft, FM; Carr, RD; Christensen, IT; Hansen, AM; Hansen, JB; Wahl, P	1
Davies, MJ	1
Göke, B; Parhofer, KG	1
Deacon, R; Dunning, BE; Foley, JE; Gutierrez, C; Paladini, S; Valentin, MA	1
Birkeland, KI; Bleskestad, IH	1
Bokvist, K; Buschard, K; Gromada, J; Holst, JJ; Høy, M; Krogsgaard Thomsen, M; Lindström, P	1
Hale, PM; Hollander, P; Khutoryansky, N; Klaff, L; McGill, J; Raskin, P; South, SA	1
Yoshida, T; Yoshikawa, T; Yoshioka, K	1
Baron, MA	1
Fernandez, D; Ghanta, A; Kauffman, GW; Sanguinetti, MC	1
Haslbeck, M; Jakob, S; Kellerer, M; Linn, T	1
Brazinsky, SA; Farrell, J; Hale, PM; Hassman, DR; Khutoryansky, N; Madder, RD; Rosenstock, J	1
de Groot, MJ; Helliwell, R; Leishman, D; Mitcheson, J; Perry, M; Sanguinetti, MC; Tristani-Firouzi, M	1
Gall, MA; Lammert, M; Minshall, ME; Nicklasson, L; Palmer, AJ; Roze, S; Spinas, GA; Valentine, WJ	1
Kolmakova, NG; Ojeda, AM; Parsons, SM	1
Berney, T; Bosco, D; Carr, RD; Donath, MY; Maedler, K; Zuellig, RA	1
Blackburn, GL	1
Li, JW; Tian, HM; Wang, JN; Yu, HL; Zhang, XX; Zhao, GZ	1
Armstrong, H; Fong, TM; Hagmann, W; Shen, CP; Xiao, JC	1
Gao, LM; Song, DQ; Yang, P	1
Erkent, U; Ertunc, M; Guc, MO; Ilhan, M; Iskit, AB; Onur, R	1
Scheen, AJ	1
Black, C; Donnelly, P; McIntyre, L; Royle, PL; Shepherd, JP; Thomas, S	1
Bieger, S; Kühner, P; Quast, U; Stephan, D; Winkler, M; Wolff, F	1
Huang, L; Li, J; Li, Q; Li, Y; Liang, J; Liu, Y; Luo, R; Ni, Z; Tian, H; Wang, N; Wu, T; Yu, H	1
Kalliokoski, A; Neuvonen, M; Neuvonen, PJ; Niemi, M	1
Kapoor, JR	1
Cruijsen, PM; Jenks, BG; Roubos, EW; Scheenen, WJ; Schoeber, JP; van den Hurk, MJ	1
Inai, Y; Kuroda, R; Ousaka, N	1
Backman, JT; Kalliokoski, A; Neuvonen, PJ; Niemi, M	1
Cabañero, D; Célérier, E; García-Nogales, P; Maldonado, R; Mata, M; Puig, MM; Roques, BP	1
Li, C; Wang, L; Wang, S; Xia, J; Zhang, G	1
Cornelius, V; Kasliwal, R; Shakir, SA; Vlckova, V; Wilton, L	1
Davis, SN	1
Osterkamp, F; Scharn, D; Stragies, R; Vossmeyer, D; Zahn, G; Zischinsky, G; Zwintscher, A	1
Aoyagi, K; Nagamatsu, S; Nakamichi, Y; Nishiwaki, C; Ohara-Imaizumi, M	1
Longo, R	1
Kalliokoski, A; Neuvonen, PJ; Niemi, M	1
LaLonde, JM; Shrivastava, I	1
Blanco, H; Góõmez, MP; Laguna, JJ; Rojas, P; Sánchez, L; Santos, A	1
Abdelmoneim, AS; Brocks, DR; Hasenbank, SE; Light, PE; Seubert, JM; Simpson, SH	1
Busse, R; Kreis, J	1
Bommineni, MR; Mullangi, R; Nadipelli, M; Sama, V; Yenumula, P	1
Bergmeier, SC; Boyd, RT; González-Cestari, TF; Henderson, BJ; Li, C; McKay, DB; Pavlovicz, RE; Yi, B	1
Chen, T; Liu, S; Lu, Y; Zhu, L; Zhu, S	1
Aguayo, E; Birkus, G; Cihlar, T; Jordan, R; Lee, G; Mello, C; Rodriguez, M	1
Jung, JS; Kim, CH; Kim, SJ; Kim, SS; Lim, SM; Park, SH; Sim, YB; Suh, HW	1
Franco, D; Froeyen, M; Hilgenfeld, R; Leyssen, P; Neyts, J; Tijsma, A; Tucker, S	1
Chen, M; Hu, C; Jia, W	1
DeFronzo, RA; Ferrannini, E	1
Acevedo, AC; Chardin, H; De Luca Canto, G; Gozal, D; Guerra, EN; Leite, AF	1
Corrales, RM; de Paiva, CS; Krauss, AH; Pelegrino, FS; Pflugfelder, SC; Tukler-Henriksson, J	1
Contreras-Ruiz, L; Krauss, AH; Masli, S; Mir, FA; Turpie, B	1
Babayan, AH; Gall, CM; Hou, B; Kantorovich, S; Lynch, G; Wang, W	1
Ejchart, A; Frączak, O; Kosson, P; Lasota, A; Maciejczyk, M; Misicka, A; Nowakowski, M; Olma, A	1
Kanai, T; Mizuno, S; Naganuma, M; Nanki, K; Sugimoto, S	1
Bilker, WB; Brensinger, CM; Chiang, C; Han, X; Hennessy, S; Leonard, CE; Li, L	1
Boeckxstaens, G; Camilleri, M	1
Finn, LA; Hussar, DA	1
Hussar, DA	1
Javaheri, S	1
Earl, DC; Van Tyle, KM	1
Lou, G; Wang, T; Xu, Q; Zhang, L	1
Cavalli, F; Franceschini, C; Pizza, F; Plazzi, G	1
Belliard, S; Berrebi-Bertrand, I; Finance, O; Giret, M; Krief, S; Lecomte, JM; Ligneau, X; Nagmar, I; Perrin, D; Robert, P; Schwartz, JC; Uguen, M	1

Reviews

30 review(s) available for phenylalanine and piperidines

Article	Year
Modulation of insulin secretion in non-insulin-dependent diabetes mellitus by two novel oral hypoglycaemic agents, NN623 and A4166. Diabetic medicine : a journal of the British Diabetic Association, 1996, Volume: 13, Issue:9 Suppl 6 Topics: Administration, Oral; Biological Availability; Blood Glucose; Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Glyburide; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Intestinal Absorption; Molecular Structure; Nateglinide; Phenylalanine; Piperidines; Reference Values; Stereoisomerism	1996
New drugs for diabetes. The Netherlands journal of medicine, 1999, Volume: 55, Issue:5 Topics: Carbamates; Chromans; Cyclohexanes; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Insulin Resistance; Metformin; Nateglinide; Phenylalanine; Piperidines; Thiazoles; Thiazolidinediones; Troglitazone	1999
Clinical efficacy of new thiazolidinediones and glinides in the treatment of type 2 diabetes mellitus. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2000, Volume: 108, Issue:3 Topics: Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Nateglinide; Phenylalanine; Pioglitazone; Piperidines; Rosiglitazone; Thiazoles; Thiazolidinediones	2000
Meglitinide analogues in the treatment of type 2 diabetes mellitus. Drugs & aging, 2000, Volume: 17, Issue:5 Topics: Benzamides; Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Glyburide; Humans; Hypoglycemic Agents; Molecular Structure; Nateglinide; Phenylalanine; Piperidines	2000
Rapid acting insulinotropic agents: restoration of early insulin secretion as a physiologic approach to improve glucose control. Current pharmaceutical design, 2001, Volume: 7, Issue:14 Topics: Animals; Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Glucose; Guanidines; Humans; Hypoglycemic Agents; Indoles; Insulin; Insulin Secretion; Isoindoles; Nateglinide; Phenylalanine; Piperidines	2001
[New drugs]. Revue medicale de Bruxelles, 2001, Volume: 22, Issue:4 Topics: Amdinocillin; Carbamates; Clopidogrel; Cyclohexanes; Drug Interactions; Humans; Hypoglycemic Agents; Nateglinide; Patient Selection; Penicillins; Phenylalanine; Piperidines; Platelet Aggregation Inhibitors; Pneumococcal Vaccines; Raloxifene Hydrochloride; Safety; Selective Estrogen Receptor Modulators; Ticlopidine	2001
Insulinotropic meglitinide analogues. Lancet (London, England), 2001, Nov-17, Volume: 358, Issue:9294 Topics: Adult; Animals; Benzamides; Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Nateglinide; Phenylalanine; Piperidines; Rats	2001
[Insulin analogs and new oral antidiabetic drugs]. Duodecim; laaketieteellinen aikakauskirja, 1999, Volume: 115, Issue:20 Topics: Administration, Oral; Carbamates; Cyclohexanes; Diabetes Mellitus; Dose-Response Relationship, Drug; Glucose; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Nateglinide; Phenylalanine; Piperidines; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors	1999
Current oral agents for type 2 diabetes. Many options, but which to choose when? Postgraduate medicine, 2002, Volume: 111, Issue:5 Topics: Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Drug Monitoring; Drug Therapy, Combination; Glycoside Hydrolases; Humans; Hypoglycemic Agents; Metformin; Nateglinide; Phenylalanine; Piperidines; Receptors, Cytoplasmic and Nuclear; Sulfonylurea Compounds; Transcription Factors	2002
Insulin secretagogues. Current medical research and opinion, 2002, Volume: 18 Suppl 1 Topics: Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Glycated Hemoglobin; Humans; Hyperglycemia; Hyperinsulinism; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Nateglinide; Phenylalanine; Piperidines; Postprandial Period; Sulfonylurea Compounds; United Kingdom	2002
[Structures and mechanisms for non SU insulin secretagogues]. Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60 Suppl 9 Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Calcium Channels; Carbamates; Cyclohexanes; Exocytosis; Humans; Hypoglycemic Agents; Indoles; Insulin; Insulin Secretion; Islets of Langerhans; Isoindoles; Nateglinide; Organ Specificity; Phenylalanine; Piperidines; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors	2002
[symbol: see text] Nateglinide and [symbol: see text] repaglinide for type 2 diabetes? Drug and therapeutics bulletin, 2003, Volume: 41, Issue:7 Topics: Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Double-Blind Method; Humans; Hypoglycemic Agents; Nateglinide; Phenylalanine; Piperidines; Randomized Controlled Trials as Topic; Treatment Outcome	2003
[Continuation 50. Type 2 diabetes: possibilities and limitations of pharmacological therapy]. MMW Fortschritte der Medizin, 2003, Dec-18, Volume: 145, Issue:51-52 Topics: 1-Deoxynojirimycin; Acarbose; Aged; Blood Glucose; Carbamates; Contraindications; Cyclohexanes; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Enzyme Inhibitors; Fasting; Follow-Up Studies; Germany; Glucosamine; Glyburide; Glycated Hemoglobin; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemia; Hypoglycemic Agents; Imino Pyranoses; Insulin; Metformin; Middle Aged; Nateglinide; Obesity; Patient Compliance; Phenylalanine; Pioglitazone; Piperidines; Practice Guidelines as Topic; Risk Factors; Rosiglitazone; Sulfonylurea Compounds; Thiazolidinediones; Time Factors	2003
Pharmacology of the meglitinide analogs: new treatment options for type 2 diabetes mellitus. Treatments in endocrinology, 2003, Volume: 2, Issue:6 Topics: Animals; Benzamides; Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Nateglinide; Phenylalanine; Piperidines	2003
Drug-drug and food-drug pharmacokinetic interactions with new insulinotropic agents repaglinide and nateglinide. Clinical pharmacokinetics, 2007, Volume: 46, Issue:2 Topics: Anti-Bacterial Agents; Area Under Curve; Biological Availability; Biotransformation; Carbamates; Cyclohexanes; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Administration Schedule; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Fasting; Food-Drug Interactions; Humans; Hypoglycemic Agents; Intestinal Absorption; Nateglinide; Phenylalanine; Piperidines; Postprandial Period	2007
Meglitinide analogues for type 2 diabetes mellitus. The Cochrane database of systematic reviews, 2007, Apr-18, Issue:2 Topics: Benzamides; Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Nateglinide; Phenylalanine; Piperidines; Randomized Controlled Trials as Topic	2007
Drugs for type 2 diabetes. Treatment guidelines from the Medical Letter, 2008, Volume: 6, Issue:71 Topics: alpha-Galactosidase; Biguanides; Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Drug Combinations; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Insulin; Nateglinide; Phenylalanine; Piperidines; Pyrazines; Sitagliptin Phosphate; Sulfonylurea Compounds; Thiazolidinediones; Triazoles	2008
Nateglinide versus repaglinide for type 2 diabetes mellitus in China. Acta diabetologica, 2009, Volume: 46, Issue:4 Topics: Carbamates; China; Cyclohexanes; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Middle Aged; Nateglinide; Phenylalanine; Piperidines	2009
Advances in oral therapy for type 2 diabetes. Postgraduate medicine, 2000, May-15, Volume: 107, Issue:6 Suppl Ke Topics: Acarbose; Administration, Oral; Blood Glucose; Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Drug Combinations; Drug Therapy, Combination; Glycated Hemoglobin; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin; Insulin Secretion; Insulin-Secreting Cells; Metformin; Nateglinide; Phenylalanine; Piperidines; Randomized Controlled Trials as Topic; Thiazolidinediones; United States; Weight Gain	2000
SLCO1B1 polymorphism and oral antidiabetic drugs. Basic & clinical pharmacology & toxicology, 2010, Volume: 107, Issue:4 Topics: Administration, Oral; Alleles; Carbamates; Cyclohexanes; Genotype; Haplotypes; Humans; Hypoglycemic Agents; Liver-Specific Organic Anion Transporter 1; Nateglinide; Organic Anion Transporters; Phenylalanine; Pioglitazone; Piperidines; Polymorphism, Genetic; Rosiglitazone; Thiazolidinediones	2010
Variations in tissue selectivity amongst insulin secretagogues: a systematic review. Diabetes, obesity & metabolism, 2012, Volume: 14, Issue:2 Topics: Animals; ATP-Binding Cassette Transporters; Carbamates; Cardiovascular Diseases; Cricetinae; Cyclohexanes; Diabetes Mellitus, Type 2; Gliclazide; Glipizide; Glyburide; Humans; Hypoglycemic Agents; Ischemic Preconditioning, Myocardial; Isoindoles; Mice; Muscle, Smooth, Vascular; Myocytes, Cardiac; Nateglinide; Phenylalanine; Piperidines; Potassium Channels, Inwardly Rectifying; Rats; Receptors, Drug; Risk Factors; Sulfonylurea Compounds; Sulfonylurea Receptors; Tolbutamide	2012
Pharmacogenomics of glinides. Pharmacogenomics, 2015, Volume: 16, Issue:1 Topics: Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Inactivation, Metabolic; Insulin; Insulin Secretion; Insulin-Secreting Cells; Isoindoles; KATP Channels; Nateglinide; Pharmacogenetics; Phenylalanine; Piperidines	2015
Impact of glucose-lowering drugs on cardiovascular disease in type 2 diabetes. European heart journal, 2015, Sep-07, Volume: 36, Issue:34 Topics: Carbamates; Clinical Trials as Topic; Coronary Artery Disease; Cyclohexanes; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Dipeptidyl-Peptidase IV Inhibitors; Glucagon-Like Peptide-1 Receptor; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Insulin; Metformin; Nateglinide; Phenylalanine; Piperidines; Sodium-Glucose Transport Proteins; Sulfonylurea Compounds; Thiazolidinediones; Treatment Outcome	2015
Diagnostic capability of salivary biomarkers in the assessment of head and neck cancer: A systematic review and meta-analysis. Oral oncology, 2015, Volume: 51, Issue:9 Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Carbocysteine; Choline; Head and Neck Neoplasms; Humans; Interleukin-8; Middle Aged; Phenylalanine; Piperidines; Saliva; Sensitivity and Specificity; Young Adult	2015
Recent trends and future directions for the medical treatment of ulcerative colitis. Clinical journal of gastroenterology, 2016, Volume: 9, Issue:6 Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Budesonide; Calcineurin Inhibitors; Colitis, Ulcerative; Drug Therapy, Combination; Drugs, Chinese Herbal; Forecasting; Gastrointestinal Agents; Glucocorticoids; Humans; Phenylalanine; Piperidines; Pyrimidines; Pyrroles; Quinazolinones; Tumor Necrosis Factor-alpha	2016
Dietary and pharmacological treatment of abdominal pain in IBS. Gut, 2017, Volume: 66, Issue:5 Topics: Abdominal Pain; Anti-Infective Agents; Antidepressive Agents; Butyrophenones; Dipeptides; GABA Agents; Gastrointestinal Agents; Histamine H1 Antagonists; Humans; Imidazoles; Irritable Bowel Syndrome; Mentha piperita; Parasympatholytics; Phenylalanine; Piperidines; Plant Oils; Probiotics; Quaternary Ammonium Compounds; Rifamycins; Rifaximin; Serotonin 5-HT3 Receptor Antagonists; Thiophenes; Visceral Pain	2017
Update on Persistent Excessive Daytime Sleepiness in OSA. Chest, 2020, Volume: 158, Issue:2 Topics: Carbamates; Disorders of Excessive Somnolence; Humans; Modafinil; Phenylalanine; Piperidines; Sleep Apnea, Obstructive; Wakefulness-Promoting Agents	2020
New pharmacologic agents for insomnia and hypersomnia. Current opinion in pulmonary medicine, 2020, Volume: 26, Issue:6 Topics: Azepines; Carbamates; Dementia; Disorders of Excessive Somnolence; GABA-A Receptor Agonists; Humans; Orexin Receptor Antagonists; Phenylalanine; Piperidines; Pyridines; Pyrimidines; Sleep Aids, Pharmaceutical; Sleep Apnea, Obstructive; Sleep Initiation and Maintenance Disorders; Trazodone; Triazoles; Zolpidem	2020
[Advances in treatment of narcolepsy]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2020, Aug-25, Volume: 49, Issue:4 Topics: Carbamates; Cataplexy; Drug Development; Humans; Narcolepsy; Phenylalanine; Piperidines	2020
A practical guide to the pharmacological and behavioral therapy of Narcolepsy. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2021, Volume: 18, Issue:1 Topics: Behavior Therapy; Carbamates; Counseling; Humans; Modafinil; Narcolepsy; Phenylalanine; Piperidines; Wakefulness-Promoting Agents	2021

Trials

9 trial(s) available for phenylalanine and piperidines

Article	Year
Modulation of insulin secretion in non-insulin-dependent diabetes mellitus by two novel oral hypoglycaemic agents, NN623 and A4166. Diabetic medicine : a journal of the British Diabetic Association, 1996, Volume: 13, Issue:9 Suppl 6 Topics: Administration, Oral; Biological Availability; Blood Glucose; Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Glyburide; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Intestinal Absorption; Molecular Structure; Nateglinide; Phenylalanine; Piperidines; Reference Values; Stereoisomerism	1996
Mealtime glucose regulation with nateglinide in healthy volunteers: comparison with repaglinide and placebo. Diabetes care, 2001, Volume: 24, Issue:1 Topics: Adolescent; Adult; Blood Glucose; Body Mass Index; Body Weight; Carbamates; Cross-Over Studies; Cyclohexanes; Female; Food; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Kinetics; Male; Middle Aged; Nateglinide; Phenylalanine; Piperidines; Placebos; Time Factors	2001
Efficacy and safety of combination therapy: repaglinide plus metformin versus nateglinide plus metformin. Diabetes care, 2003, Volume: 26, Issue:7 Topics: Area Under Curve; Blood Glucose; Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Male; Metformin; Middle Aged; Nateglinide; Phenylalanine; Piperidines; Postprandial Period; Safety	2003
Repaglinide versus nateglinide monotherapy: a randomized, multicenter study. Diabetes care, 2004, Volume: 27, Issue:6 Topics: Biomarkers; Body Mass Index; Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Diet, Diabetic; Exercise; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Middle Aged; Nateglinide; Phenylalanine; Piperidines; Time Factors	2004
[Comparison of efficacy between nateglinide and repaglinide in treating type 2 diabetes: a randomized controlled double-blind clinical trial]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2005, Volume: 36, Issue:2 Topics: Adult; Blood Glucose; Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Male; Middle Aged; Nateglinide; Phenylalanine; Piperidines	2005
Improvement of insulin sensitivity and beta-cell function by nateglinide and repaglinide in type 2 diabetic patients - a randomized controlled double-blind and double-dummy multicentre clinical trial. Diabetes, obesity & metabolism, 2007, Volume: 9, Issue:4 Topics: Adult; Age of Onset; Aged; Area Under Curve; Asian People; Blood Glucose; Carbamates; China; Cyclohexanes; Diabetes Mellitus, Type 2; Double-Blind Method; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Middle Aged; Nateglinide; Phenylalanine; Piperidines	2007
Different effects of SLCO1B1 polymorphism on the pharmacokinetics and pharmacodynamics of repaglinide and nateglinide. Journal of clinical pharmacology, 2008, Volume: 48, Issue:3 Topics: Analysis of Variance; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Blood Glucose; Carbamates; Chromatography, Liquid; Cyclohexanes; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Dose-Response Relationship, Drug; Genotype; Half-Life; Humans; Hypoglycemic Agents; Liver-Specific Organic Anion Transporter 1; Metabolic Clearance Rate; Molecular Structure; Nateglinide; Organic Anion Transporters; Pharmacogenetics; Phenylalanine; Piperidines; Polymorphism, Single Nucleotide; Tablets; Tandem Mass Spectrometry	2008
Effects of the SLCO1B11B haplotype on the pharmacokinetics and pharmacodynamics of repaglinide and nateglinide. Pharmacogenetics and genomics, 2008, Volume: 18, Issue:11* Topics: Administration, Oral; Adult; Area Under Curve; Blood Glucose; Carbamates; Cyclohexanes; Female; Haplotypes; Humans; Hypoglycemic Agents; Liver-Specific Organic Anion Transporter 1; Male; Nateglinide; Organic Anion Transporters; Phenylalanine; Piperidines; Time Factors	2008
Nateglinide versus repaglinide for type 2 diabetes mellitus in China. Acta diabetologica, 2009, Volume: 46, Issue:4 Topics: Carbamates; China; Cyclohexanes; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Middle Aged; Nateglinide; Phenylalanine; Piperidines	2009

Other Studies

76 other study(ies) available for phenylalanine and piperidines

Article	Year
Effects of acetylthrombin on protein C activation and fibrinogen clotting. Thrombosis research, 1990, Aug-15, Volume: 59, Issue:4 Topics: Amides; Amino Acid Sequence; Animals; Antithrombin III; Antithrombins; Blood Coagulation; Dipeptides; Fibrinogen; Hirudins; Male; Molecular Sequence Data; Partial Thromboplastin Time; Phenylalanine; Piperidines; Protein C; Rabbits; Receptors, Cell Surface; Receptors, Thrombin; Serine Endopeptidases; Serine Proteinase Inhibitors; Substrate Specificity; Thrombin	1990
Chemical modification of alpha-thrombin and in vitro characterization of its anticoagulant activity. Biochemistry international, 1990, Volume: 22, Issue:1 Topics: Animals; Anticoagulants; Antithrombin III; Blood Coagulation; Cattle; Chromatography, High Pressure Liquid; Fibrinogen; Humans; Phenylalanine; Piperidines; Protein C; Rabbits; Receptors, Cell Surface; Receptors, Thrombin; Thrombin	1990
[Difficulties in the study of the kinetics of the generation of IIa and Xa in the monitoring of treatment with low molecular weight heparin]. Journal des maladies vasculaires, 1987, Volume: 12 Suppl B Topics: Factor X; Heparin, Low-Molecular-Weight; Hirudins; Humans; Phenylalanine; Piperidines; Prothrombin; Thrombin; Vitamin K	1987
Reduction of a benzamidoxime derivative to the corresponding benzamidine in vivo and in vitro. Die Pharmazie, 1988, Volume: 43, Issue:8 Topics: Animals; Bile; Biotransformation; Chromatography, High Pressure Liquid; Dipeptides; In Vitro Techniques; Infusions, Intravenous; Liver; Oxidation-Reduction; Phenylalanine; Piperidines; Portal Vein; Rabbits; Rats; Thrombin	1988
Inhibition of bone resorption in vitro by serine-esterase inhibitors. Biochimica et biophysica acta, 1988, Feb-17, Volume: 964, Issue:2 Topics: Acetylglucosaminidase; Amino Acid Chloromethyl Ketones; Animals; Animals, Newborn; Bone and Bones; Bone Resorption; Calcium; Esterases; Glucuronidase; Hydroxycholecalciferols; Hydroxyproline; L-Lactate Dehydrogenase; Mice; Organ Culture Techniques; Parathyroid Hormone; Phenylalanine; Phosphates; Piperidines	1988
Kinetic study of the inhibition of the amidolytic activity of thrombin by benzamidine and N-dansyl-(p-guanidino)-phenylalanine-piperidide (I-2581). The International journal of biochemistry, 1987, Volume: 19, Issue:11 Topics: Amides; Amidines; Benzamidines; Humans; Hydrolysis; Indicators and Reagents; Kinetics; Phenylalanine; Piperidines; Thrombin	1987
The antiviral activity of some related benzo(b) thiophene derivatives. II. Anti-influenza activity. Archiv fur die gesamte Virusforschung, 1974, Volume: 46, Issue:1-2 Topics: Amantadine; Animals; Antigens, Viral; Antiviral Agents; Cell Line; Chemical Phenomena; Chemistry; Fluorescent Antibody Technique; Haplorhini; HeLa Cells; Hemadsorption; Humans; Kidney; Orthomyxoviridae; Phenylalanine; Piperidines; Pyrrolidines; Thiophenes; Time Factors; Virus Replication	1974
Pharmacologic studies with 7-benzyl-1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid. The Journal of pharmacology and experimental therapeutics, 1967, Volume: 158, Issue:2 Topics: Amphetamine; Animals; Catecholamines; Chlorine; Depression; Drug Antagonism; Drug Synergism; Humans; Methyltyrosines; Mice; Motor Activity; Movement Disorders; Naphthyridines; Norepinephrine; Phenoxybenzamine; Phenylalanine; Piperidines; Reserpine; Stimulation, Chemical	1967
Variation in hydroxytryptamine metabolism in the rat: effects on the neurochemical response to phencyclidine. The Journal of pharmacy and pharmacology, 1971, Volume: 23, Issue:9 Topics: Anesthetics; Animals; Brain; Hydroxyindoleacetic Acid; Phenylalanine; Piperidines; Rats; Serotonin	1971
Increased levels of pisatin and phenylalanine ammonia lyase activity in Pisum sativum treated with antihistaminic, antiviral, antimalarial, tranquilizing, or other drugs. Biochemical and biophysical research communications, 1972, Jan-14, Volume: 46, Issue:1 Topics: Antidepressive Agents; Antitussive Agents; Antiviral Agents; Chloroquine; Deamination; Ethylamines; Fluorenes; Histamine H1 Antagonists; Imipramine; Ketones; Lectins; Leucine; Lyases; Parasympatholytics; Phenothiazines; Phenylalanine; Piperidines; Plant Lectins; Plant Proteins; Plants, Edible; Propantheline; Quinacrine; Stimulation, Chemical; Tranquilizing Agents; Trimeprazine	1972
Evidence for a hepatic transport system not responsive to glucagon or theophylline. Biochemical and biophysical research communications, 1971, Apr-02, Volume: 43, Issue:1 Topics: Adenylyl Cyclases; Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport; Carbon Isotopes; Carboxylic Acids; Cyclopropanes; Diaphragm; Glucagon; In Vitro Techniques; Injections, Intraperitoneal; Leucine; Liver; Male; Methionine; Muscle, Smooth; Phenylalanine; Piperidines; Rats; Sodium; Theophylline	1971
Chemistry of amino acids. VII. The synthesis and spectral studies of some 2-piperidones bearing beta-keto ester groups. Chemical & pharmaceutical bulletin, 1969, Volume: 17, Issue:3 Topics: Esters; Indoles; Keto Acids; Phenylalanine; Piperidines; Spectrum Analysis	1969
Two classes of structurally different antagonists display similar species preference for the human tachykinin neurokinin3 receptor. Molecular pharmacology, 1995, Volume: 48, Issue:4 Topics: Animals; Benzamides; Binding, Competitive; CHO Cells; Cricetinae; Dipeptides; Humans; Inositol Phosphates; Iodine Radioisotopes; Kinetics; Mutation; Neurokinin B; Phenylalanine; Piperidines; Radioligand Assay; Rats; Receptors, Neurokinin-3; Species Specificity; Structure-Activity Relationship	1995
Insulinotropic action of meglitinide analogs: concentration-response relationship and nutrient dependency. Diabetes research (Edinburgh, Scotland), 1994, Volume: 27, Issue:2 Topics: Animals; Benzamides; Carbamates; Cyclohexanes; Female; Glucose; Hypoglycemic Agents; In Vitro Techniques; Indoles; Insulin; Insulin Secretion; Islets of Langerhans; Isoindoles; Molecular Structure; Nateglinide; Phenylalanine; Piperidines; Rats; Structure-Activity Relationship; Succinates	1994
Sensitivity of the fibrinogen clotting time: an in vitro test of potential thrombogenicity. Vox sanguinis, 1994, Volume: 66, Issue:1 Topics: Antithrombin III; Benzamidines; Blood Coagulation; Blood Coagulation Factors; Blood Coagulation Tests; Fibrinogen; Heparin; Hirudins; Humans; Phenylalanine; Piperidines; Reproducibility of Results; Temperature; Thrombin; Thrombosis	1994
Conformational analysis of non-sulfonylurea hypoglycemic agents of the meglitinide family. Biochemical pharmacology, 1995, Nov-27, Volume: 50, Issue:11 Topics: Benzamides; Carbamates; Cyclohexanes; Drug Design; Glyburide; Hypoglycemic Agents; Indoles; Isoindoles; Molecular Conformation; Nateglinide; Phenylalanine; Piperidines; Stereoisomerism; Structure-Activity Relationship; Sulfonylurea Compounds	1995
Insulinotropic action of meglitinide analogues: modulation by an activator of ATP-sensitive K+ channels and high extracellular K+ concentrations. Pharmacological research, 1995, Volume: 32, Issue:3 Topics: Animals; Benzamides; Carbamates; Cyclohexanes; Female; Hypoglycemic Agents; Indoles; Insulin; Insulin Secretion; Islets of Langerhans; Isoindoles; Nateglinide; Phenylalanine; Piperidines; Potassium; Rats	1995
Purification and characterization of a fibrinogen-clotting enzyme from the venom of jararacuçu (Bothrops jararacussu). Toxicon : official journal of the International Society on Toxinology, 1996, Volume: 34, Issue:7 Topics: Agmatine; Animals; Antithrombins; Aprotinin; Bothrops; Chemical Fractionation; Chromatography, Gel; Chromatography, High Pressure Liquid; Crotalid Venoms; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Enzyme Inhibitors; Enzyme Stability; Glycoproteins; Heparin; Hydrogen-Ion Concentration; Hydrolysis; Isoelectric Focusing; Molecular Weight; Neuraminidase; Phenylalanine; Piperidines; Rats; Serine Proteinase Inhibitors; Tosyllysine Chloromethyl Ketone	1996
Effects of the methyl esters of pyruvate, succinate and glutamate on the secretory response to meglitinide analogues in rat pancreatic islets. Pharmacological research, 1996, Volume: 33, Issue:3 Topics: Animals; Carbamates; Cells, Cultured; Cyclohexanes; Glucose; Glutamates; Hypoglycemic Agents; Indoles; Insulin; Insulin Secretion; Islets of Langerhans; Isoindoles; Nateglinide; Phenylalanine; Piperidines; Pyruvates; Rats; Succinates	1996
Synthesis and structure-activity relationships of potent thrombin inhibitors: piperazides of 3-amidinophenylalanine. Journal of medicinal chemistry, 1997, Sep-12, Volume: 40, Issue:19 Topics: Animals; Antithrombins; Binding Sites; Blood Coagulation; Crystallography, X-Ray; Dipeptides; Factor Xa Inhibitors; Fibrinolysin; Humans; Indicators and Reagents; Metabolic Clearance Rate; Phenylalanine; Piperazines; Piperidines; Protease Inhibitors; Prothrombin Time; Rats; Stereoisomerism; Structure-Activity Relationship; Thrombin; Trypsin	1997
Stimulation of insulin and somatostatin release by two meglitinide analogs. Endocrine, 1997, Volume: 7, Issue:3 Topics: Animals; Benzamides; Blood Glucose; Carbamates; Cyclohexanes; Female; Glucagon; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Nateglinide; Perfusion; Phenylalanine; Piperidines; Rats; Rats, Wistar; Somatostatin	1997
A comparative SAR study of thrombin receptor derived non peptide mimetics: importance of phenyl/guanidino proximity for activity. Amino acids, 1998, Volume: 15, Issue:3 Topics: Arginine; Drug Design; Humans; Models, Molecular; Molecular Conformation; Molecular Mimicry; Oligopeptides; Peptides; Phenylalanine; Piperazines; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Thrombin; Structure-Activity Relationship	1998
Tissue selectivity of antidiabetic agent nateglinide: study on cardiovascular and beta-cell K(ATP) channels. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 291, Issue:3 Topics: Animals; Aorta, Thoracic; Carbamates; Cardiovascular System; Coronary Vessels; Cyclohexanes; Glyburide; Heart; Hypoglycemic Agents; Islets of Langerhans; Male; Muscle, Smooth, Vascular; Nateglinide; Phenylalanine; Piperidines; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley; Swine	1999
Selectivity of prandial glucose regulators: nateglinide, but not repaglinide, accelerates exocytosis in rat pancreatic A-cells. European journal of pharmacology, 1999, Dec-10, Volume: 386, Issue:1 Topics: Animals; ATP-Binding Cassette Transporters; Calcium; Carbamates; Cyclohexanes; Eating; Electrophysiology; Exocytosis; Glucagon; Glucose; Hypoglycemic Agents; In Vitro Techniques; Islets of Langerhans; KATP Channels; Kinetics; Male; Nateglinide; Patch-Clamp Techniques; Phenylalanine; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Inbred Lew; Stimulation, Chemical	1999
Pancreatic beta-cell K(ATP) channel activity and membrane-binding studies with nateglinide: A comparison with sulfonylureas and repaglinide. The Journal of pharmacology and experimental therapeutics, 2000, Volume: 293, Issue:2 Topics: Animals; ATP-Binding Cassette Transporters; Binding, Competitive; Carbamates; Cell Membrane; Cell Separation; Cells, Cultured; Cyclohexanes; Glucose; Glyburide; Glycosyltransferases; Humans; Hypoglycemia; Hypoglycemic Agents; In Vitro Techniques; Insulin; Islets of Langerhans; KATP Channels; Kinetics; Male; Membrane Proteins; Nateglinide; Patch-Clamp Techniques; Phenylalanine; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley; Repressor Proteins; Saccharomyces cerevisiae Proteins; Sulfonylurea Compounds	2000
Vascular endothelial growth factor-stimulated endothelial cells promote adhesion and activation of platelets. Blood, 2000, Dec-15, Volume: 96, Issue:13 Topics: Adult; Blood Platelets; Cell Division; Cells, Cultured; Endothelial Growth Factors; Endothelium, Vascular; Fibroblast Growth Factor 2; Flow Cytometry; Humans; Lymphokines; Microscopy, Fluorescence; Neoplasms; Neovascularization, Pathologic; Phenylalanine; Piperidines; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Thrombin; Thrombophilia; Umbilical Veins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2000
Differential effects of short and long duration insulinotropic agents on meal-related glucose excursions. Diabetes, obesity & metabolism, 2001, Volume: 3, Issue:2 Topics: Animals; Blood Glucose; Carbamates; Cyclohexanes; Food; Glipizide; Glucagon; Insulin; Insulin Secretion; Male; Nateglinide; Phenylalanine; Piperidines; Rats; Rats, Sprague-Dawley	2001
Effect of insulinotropic agent nateglinide on Kv and Ca(2+) channels in pancreatic beta-cell. European journal of pharmacology, 2001, Sep-14, Volume: 427, Issue:2 Topics: Animals; Calcium Channels; Carbamates; Cyclohexanes; Dose-Response Relationship, Drug; Electric Stimulation; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Male; Membrane Potentials; Nateglinide; Patch-Clamp Techniques; Phenylalanine; Piperidines; Potassium Channels; Rats; Rats, Sprague-Dawley	2001
Type 2 diabetes management. British journal of community nursing, 2002, Volume: 7, Issue:1 Topics: Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Metformin; Nateglinide; Phenylalanine; Piperidines	2002
Interaction of nateglinide with K(ATP) channel in beta-cells underlies its unique insulinotropic action. European journal of pharmacology, 2002, May-03, Volume: 442, Issue:1-2 Topics: Adenosine Triphosphate; Animals; Carbamates; Cyclohexanes; Dose-Response Relationship, Drug; Glucose; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Membrane Potentials; Nateglinide; Phenylalanine; Piperidines; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Sulfonylurea Compounds; Time Factors	2002
Effects of [(pF)Phe(4)]nociceptin/orphanin FQ-(1-13)NH(2) on GTPgamma(35)S binding and cAMP formation in Chinese hamster ovary cells expressing the human nociceptin/orphanin FQ receptor. European journal of pharmacology, 2002, May-17, Volume: 443, Issue:1-3 Topics: Animals; Aza Compounds; Benzimidazoles; Carboxylic Acids; CHO Cells; Cricetinae; Cyclic AMP; Female; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Narcotic Antagonists; Nociceptin; Nociceptin Receptor; Opioid Peptides; Ovary; Phenylalanine; Piperidines; Receptors, Opioid	2002
Nateglinide, but not repaglinide, stimulates growth hormone release in rat pituitary cells by inhibition of K channels and stimulation of cyclic AMP-dependent exocytosis. European journal of endocrinology, 2002, Volume: 147, Issue:1 Topics: Animals; Calcium; Carbamates; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclohexanes; Delayed Rectifier Potassium Channels; Exocytosis; Growth Hormone; Growth Hormone-Releasing Hormone; Hypoglycemic Agents; Male; Membrane Potentials; Nateglinide; Patch-Clamp Techniques; Phenylalanine; Piperidines; Pituitary Gland; Potassium; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Rats; Rats, Sprague-Dawley	2002
Differential interactions of nateglinide and repaglinide on the human beta-cell sulphonylurea receptor 1. Diabetes, 2002, Volume: 51, Issue:9 Topics: ATP-Binding Cassette Transporters; Binding, Competitive; Carbamates; Cell Line; Cyclohexanes; Drug Interactions; Electrophysiology; Humans; Islets of Langerhans; Nateglinide; Phenylalanine; Piperidines; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors; Tolbutamide	2002
Glucose-dependent and glucose-sensitizing insulinotropic effect of nateglinide: comparison to sulfonylureas and repaglinide. International journal of experimental diabetes research, 2001, Volume: 2, Issue:1 Topics: Animals; Carbamates; Cyclohexanes; Glucose; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Nateglinide; Phenylalanine; Piperidines; Rats; Rats, Sprague-Dawley; Sulfonylurea Compounds	2001
Effectiveness of nateglinide on in vitro insulin secretion from rat pancreatic islets desensitized to sulfonylureas. International journal of experimental diabetes research, 2001, Volume: 2, Issue:1 Topics: Animals; Carbamates; Cyclohexanes; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Male; Nateglinide; Phenylalanine; Piperidines; Rats; Rats, Sprague-Dawley; Sulfonylurea Compounds	2001
[Glinides and glitazones in diabetes treatment. Are they really effective?]. MMW Fortschritte der Medizin, 2002, May-02, Volume: 144, Issue:18 Topics: Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Insulin; Nateglinide; Phenylalanine; Pioglitazone; Piperidines; Rosiglitazone; Thiazoles; Thiazolidinediones; Treatment Outcome	2002
Pharmacologic restoration of the early insulin response in pre-diabetic monkeys controls mealtime glucose excursions without peripheral hyperinsulinaemia. Diabetologia, 2003, Volume: 46 Suppl 1 Topics: Animals; Blood Glucose; Carbamates; Cyclohexanes; Fatty Acids, Nonesterified; Food; Glucagon; Hypoglycemic Agents; Insulin; Insulin Secretion; Kinetics; Macaca fascicularis; Male; Nateglinide; Phenylalanine; Piperidines	2003
[Differences between oral antidiabetics]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2003, Mar-20, Volume: 123, Issue:6 Topics: Administration, Oral; Carbamates; Cyclohexanes; Diabetes Mellitus; Glipizide; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Nateglinide; Phenylalanine; Piperidines; Sulfonylurea Compounds	2003
Repaglinide at a cellular level. Diabetes, nutrition & metabolism, 2002, Volume: 15, Issue:6 Suppl Topics: Animals; Carbamates; Cyclohexanes; Electrophysiology; Exocytosis; Hypoglycemic Agents; Islets of Langerhans; Membrane Potentials; Nateglinide; Phenylalanine; Piperidines; Postprandial Period; Potassium Channels; Rats	2002
Glimepiride and serum adiponectin level in type 2 diabetic subjects: response to Nagasaka et al. Diabetes care, 2003, Volume: 26, Issue:12 Topics: Adiponectin; Blood Glucose; Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Intercellular Signaling Peptides and Proteins; Nateglinide; Phenylalanine; Piperidines; Proteins; Sulfonylurea Compounds	2003
Comparison of repaglinide and nateglinide in combination with metformin: response to Raskin et al. Diabetes care, 2003, Volume: 26, Issue:12 Topics: Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Metformin; Nateglinide; Phenylalanine; Piperidines	2003
Physicochemical features of the HERG channel drug binding site. The Journal of biological chemistry, 2004, Mar-12, Volume: 279, Issue:11 Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Benzopyrans; Binding Sites; Biophysical Phenomena; Biophysics; Cation Transport Proteins; Cisapride; Ether-A-Go-Go Potassium Channels; Histamine H1 Antagonists; Inhibitory Concentration 50; Kinetics; Models, Molecular; Molecular Sequence Data; Mutation; Oocytes; Phenylalanine; Piperidines; Point Mutation; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Binding; Protein Structure, Tertiary; RNA, Complementary; Sequence Homology, Amino Acid; Serotonin Receptor Agonists; Temperature; Terfenadine; Tyrosine; Xenopus	2004
Structural determinants of HERG channel block by clofilium and ibutilide. Molecular pharmacology, 2004, Volume: 66, Issue:2 Topics: Amino Acid Substitution; Animals; Anti-Arrhythmia Agents; Aspartic Acid; Benzopyrans; Binding Sites; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Oocytes; Phenethylamines; Phenylalanine; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Quaternary Ammonium Compounds; Serine; Sulfonamides; Tyrosine; Xenopus laevis	2004
Comparing the long-term cost-effectiveness of repaglinide plus metformin versus nateglinide plus metformin in type 2 diabetes patients with inadequate glycaemic control: an application of the CORE Diabetes Model in type 2 diabetes. Current medical research and opinion, 2004, Volume: 20 Suppl 1 Topics: Carbamates; Cohort Studies; Computer Simulation; Cost of Illness; Cost-Benefit Analysis; Cyclohexanes; Decision Support Systems, Clinical; Diabetes Complications; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glycated Hemoglobin; Health Care Costs; Humans; Male; Metformin; Middle Aged; Models, Econometric; Nateglinide; Outcome Assessment, Health Care; Phenylalanine; Piperidines; Quality-Adjusted Life Years	2004
Acetylcholine binding site in the vesicular acetylcholine transporter. Biochemistry, 2004, Sep-07, Volume: 43, Issue:35 Topics: Acetylcholine; Alanine; Allosteric Site; Animals; Binding Sites; Membrane Transport Proteins; Mutagenesis, Site-Directed; PC12 Cells; Phenylalanine; Piperidines; Protein Transport; Rats; Subcellular Fractions; Synaptic Vesicles; Transfection; Tritium; Tyrosine; Vesicular Acetylcholine Transport Proteins; Vesicular Transport Proteins	2004
Sulfonylurea induced beta-cell apoptosis in cultured human islets. The Journal of clinical endocrinology and metabolism, 2005, Volume: 90, Issue:1 Topics: Adult; Aged; Apoptosis; Calcium; Carbamates; Cells, Cultured; Cyclohexanes; Dose-Response Relationship, Drug; Glyburide; Humans; Hypoglycemic Agents; Insulin; Islets of Langerhans; Middle Aged; Nateglinide; Phenylalanine; Piperidines	2005
Treating type 2 diabetes. When diet and exercise aren't enough, a broad range of medications can help control our blood sugar. Health news (Waltham, Mass.), 2004, Volume: 10, Issue:8 Topics: Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Drug Administration Schedule; Eating; Humans; Hypoglycemic Agents; Nateglinide; Phenylalanine; Piperidines	2004
F200A substitution in the third transmembrane helix of human cannabinoid CB1 receptor converts AM2233 from receptor agonist to inverse agonist. European journal of pharmacology, 2006, Feb-15, Volume: 531, Issue:1-3 Topics: Alanine; Amino Acid Substitution; Animals; Binding Sites; Binding, Competitive; CHO Cells; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Cyclohexanols; Dose-Response Relationship, Drug; Gene Expression; Humans; Indoles; Molecular Structure; Pertussis Toxin; Phenylalanine; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Tritium	2006
[Synthesis and insulinotropic activity of 2-benzylidenesuccinic acid derivatives]. Yao xue xue bao = Acta pharmaceutica Sinica, 2005, Volume: 40, Issue:12 Topics: Animals; Benzylidene Compounds; Blood Glucose; Carbamates; Cyclohexanes; Hypoglycemic Agents; Indoles; Isoindoles; Mice; Molecular Structure; Nateglinide; Phenylalanine; Piperidines; Structure-Activity Relationship; Succinates	2005
Glibenclamide attenuates the antiarrhythmic effect of endotoxin with a mechanism not involving K(ATP) channels. Vascular pharmacology, 2007, Volume: 46, Issue:2 Topics: Action Potentials; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Blood Pressure; Carbamates; Cyclohexanes; Disease Models, Animal; Drug Interactions; Endotoxemia; Glyburide; Heart Atria; Heart Conduction System; Lipopolysaccharides; Male; Myocardial Ischemia; Nateglinide; Phenylalanine; Piperidines; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Tachycardia, Ventricular; Tetraethylammonium; Time Factors; Ventricular Fibrillation; Ventricular Premature Complexes	2007
Testing the bipartite model of the sulfonylurea receptor binding site: binding of A-, B-, and A + B-site ligands. The Journal of pharmacology and experimental therapeutics, 2007, Volume: 322, Issue:2 Topics: Amino Acid Substitution; Animals; ATP-Binding Cassette Transporters; Binding Sites; Binding, Competitive; Carbamates; Cell Line; Cyclohexanes; Dose-Response Relationship, Drug; Glyburide; Hypoglycemic Agents; KATP Channels; Ligands; Mice; Molecular Structure; Nateglinide; Phenylalanine; Piperidines; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Binding; Radioligand Assay; Rats; Receptors, Drug; Sulfonylurea Compounds; Sulfonylurea Receptors; Transfection	2007
Postprandial hyperglycemia: are all sulfonylureas created equal? The American journal of cardiology, 2008, Feb-15, Volume: 101, Issue:4 Topics: Carbamates; Cyclohexanes; Glipizide; Humans; Hyperglycemia; Hyperlipidemias; Hypoglycemic Agents; Nateglinide; Phenylalanine; Piperidines; Postprandial Period; Sulfonylurea Compounds	2008
Intracellular signal transduction by the extracellular calcium-sensing receptor of Xenopus melanotrope cells. General and comparative endocrinology, 2008, Volume: 157, Issue:2 Topics: Androstadienes; Animals; Blotting, Western; Butadienes; Cells, Cultured; Cholera Toxin; Cyclic AMP; Genistein; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; Intracellular Space; Mitogen-Activated Protein Kinases; Nitriles; Pertussis Toxin; Phenylalanine; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Piperidines; Radioimmunoassay; Receptors, Calcium-Sensing; Signal Transduction; Wortmannin; Xenopus laevis	2008
Chain-terminus triggered chiral memory in an optically inactive 3(10)-helical peptide. Journal of the American Chemical Society, 2008, Sep-17, Volume: 130, Issue:37 Topics: Aminoisobutyric Acids; Circular Dichroism; Kinetics; Nuclear Magnetic Resonance, Biomolecular; Oligopeptides; Phenylalanine; Piperidines; Protein Structure, Secondary; Stereoisomerism	2008
The pro-nociceptive effects of remifentanil or surgical injury in mice are associated with a decrease in delta-opioid receptor mRNA levels: Prevention of the nociceptive response by on-site delivery of enkephalins. Pain, 2009, Volume: 141, Issue:1-2 Topics: Analgesics; Animals; Disease Models, Animal; Disulfides; Down-Regulation; Enkephalins; Ganglia, Spinal; Male; Methyl Ethers; Mice; Pain Measurement; Pain Threshold; Pain, Postoperative; Phenylalanine; Piperidines; Protein Precursors; Receptors, Opioid, delta; Receptors, Opioid, mu; Remifentanil; RNA, Messenger; Sevoflurane; Spinal Cord; Time Factors	2009
Hypoglycaemia with oral antidiabetic drugs: results from prescription-event monitoring cohorts of rosiglitazone, pioglitazone, nateglinide and repaglinide. Drug safety, 2009, Volume: 32, Issue:5 Topics: Administration, Oral; Adult; Adverse Drug Reaction Reporting Systems; Carbamates; Cohort Studies; Cyclohexanes; Diabetes Mellitus, Type 2; Drug Monitoring; Drug Prescriptions; Female; Humans; Hypoglycemia; Hypoglycemic Agents; Incidence; Male; Middle Aged; Nateglinide; Phenylalanine; Pioglitazone; Piperidines; Rosiglitazone; Sex Factors; Thiazolidinediones	2009
SAR of N-phenyl piperidine based oral integrin alpha5beta1 antagonists. Bioorganic & medicinal chemistry letters, 2010, Jan-01, Volume: 20, Issue:1 Topics: Administration, Oral; Aminopyridines; Animals; Dogs; Drug Design; Integrin alpha5beta1; Male; Phenylalanine; Piperidines; Rats; Stereoisomerism; Structure-Activity Relationship	2010
Glinide, but not sulfonylurea, can evoke insulin exocytosis by repetitive stimulation: imaging analysis of insulin exocytosis by secretagogue-induced repetitive stimulations. Experimental diabetes research, 2009, Volume: 2009 Topics: Animals; Calcium; Carbamates; Cell Fusion; Cells, Cultured; Cyclohexanes; Exocytosis; Glucose; Hypoglycemic Agents; Insulin; Insulin Secretion; Insulin-Secreting Cells; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Nateglinide; Phenylalanine; Piperidines; Sulfonylurea Compounds	2009
Diabetes under control: Understanding oral antidiabetic agents. The American journal of nursing, 2010, Volume: 110, Issue:2 Topics: Administration, Oral; Biguanides; Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Drug Combinations; Drug Therapy, Combination; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Nateglinide; Phenylalanine; Piperidines; Sulfonylurea Compounds	2010
Enhanced dynamics of HIV gp120 glycoprotein by small molecule binding. Biochemistry, 2011, May-17, Volume: 50, Issue:19 Topics: Animals; CD4 Antigens; Crystallography, X-Ray; HIV Envelope Protein gp120; Models, Molecular; Molecular Dynamics Simulation; Mutagenesis; Oxalates; Phenylalanine; Piperidines; Protein Binding; Protein Stability; Protein Structure, Secondary; Protein Structure, Tertiary; Protein Unfolding; Scorpion Venoms; Scorpions	2011
Hypersensitivity to repaglinide. Journal of investigational allergology & clinical immunology, 2011, Volume: 21, Issue:3 Topics: Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Drug Hypersensitivity; Erythema; Exanthema; Humans; Hypoglycemic Agents; Male; Middle Aged; Nateglinide; Patch Tests; Phenylalanine; Piperidines	2011
From evidence assessments to coverage decisions?: the case example of glinides in Germany. Health policy (Amsterdam, Netherlands), 2012, Volume: 104, Issue:1 Topics: Carbamates; Cost Control; Cost-Benefit Analysis; Costs and Cost Analysis; Cyclohexanes; Diabetes Mellitus; Eligibility Determination; Evidence-Based Medicine; Germany; Health Care Reform; Health Policy; Humans; Hypoglycemic Agents; Insurance Coverage; Nateglinide; National Health Programs; Phenylalanine; Piperidines; Prescription Drugs; Reimbursement Mechanisms; Technology Assessment, Biomedical	2012
Effect of piperine on antihyperglycemic activity and pharmacokinetic profile of nateglinide. Arzneimittel-Forschung, 2012, Volume: 62, Issue:8 Topics: Alkaloids; Alloxan; Animals; Benzodioxoles; Cyclohexanes; Diabetes Mellitus, Experimental; Drug Interactions; Drug Synergism; Glucose Tolerance Test; Hypoglycemic Agents; Male; Nateglinide; Phenylalanine; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Wistar	2012
Defining the putative inhibitory site for a selective negative allosteric modulator of human α4β2 neuronal nicotinic receptors. ACS chemical neuroscience, 2012, Sep-19, Volume: 3, Issue:9 Topics: Binding Sites; Biphenyl Compounds; Calcium; Humans; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Neurons; Nicotinic Antagonists; Phenylalanine; Piperidines; Receptors, Nicotinic; Structure-Activity Relationship; Threonine	2012
Two nitrogen-containing ligands as inhibitors of metal-induced amyloid β-peptide aggregation. CNS & neurological disorders drug targets, 2014, Volume: 13, Issue:1 Topics: Amyloid beta-Peptides; Aza Compounds; Boron Compounds; Chelating Agents; Copper; Dose-Response Relationship, Drug; Humans; Metals; Microscopy, Atomic Force; Peptide Fragments; Phenylalanine; Piperidines; Protein Conformation; Spectrometry, Fluorescence; Zinc	2014
Multiple classes of antiviral agents exhibit in vitro activity against human rhinovirus type C. Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:3 Topics: Antiviral Agents; Common Cold; Dose-Response Relationship, Drug; HeLa Cells; Humans; In Vitro Techniques; Isoxazoles; Oxadiazoles; Oxazoles; Phenylalanine; Piperidines; Pyridazines; Pyrrolidinones; Replicon; Rhinovirus; RNA, Viral; Tubercidin; Valine; Virus Replication	2014
Effects of nateglinide and repaglinide administered intracerebroventricularly on the CA3 hippocampal neuronal cell death and hyperglycemia induced by kainic acid in mice. Brain research bulletin, 2014, Volume: 104 Topics: Animals; Blood Glucose; CA3 Region, Hippocampal; Carbamates; Cell Death; Corticosterone; Cyclohexanes; Excitatory Amino Acid Agonists; Hypoglycemic Agents; Infusions, Intraventricular; Insulin; Kainic Acid; Male; Mice; Mice, Inbred ICR; Nateglinide; Neurons; Phenylalanine; Piperidines	2014
The capsid binder Vapendavir and the novel protease inhibitor SG85 inhibit enterovirus 71 replication. Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:11 Topics: Antiviral Agents; Benzimidazoles; Capsid; Capsid Proteins; Drug Resistance, Viral; Enterovirus A, Human; Enterovirus Infections; Isoxazoles; Molecular Docking Simulation; Oximes; Phenylalanine; Piperidines; Protease Inhibitors; Protein Binding; Pyridazines; Pyrrolidinones; Sulfonamides; Valine; Virus Replication	2014
Improvement of Outcome Measures of Dry Eye by a Novel Integrin Antagonist in the Murine Desiccating Stress Model. Investigative ophthalmology & visual science, 2015, Volume: 56, Issue:10 Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Biomarkers; Cell Adhesion; Cells, Cultured; Cornea; Dendritic Cells; Disease Models, Animal; Dry Eye Syndromes; Female; Flow Cytometry; Integrin alpha Chains; Integrin alpha4; Integrin alpha4beta1; Leukocytes; Mice; Mice, Inbred C57BL; Organic Chemicals; Phenylalanine; Piperidines; Vascular Cell Adhesion Molecule-1	2015
Sjögren's syndrome associated dry eye in a mouse model is ameliorated by topical application of integrin α4 antagonist GW559090. Experimental eye research, 2016, Volume: 143 Topics: Administration, Topical; Animals; Cell Count; Dexamethasone; Disease Models, Animal; Dry Eye Syndromes; Fluorescein; Glucocorticoids; Goblet Cells; Integrin alpha4beta1; Interleukin-1beta; Mice; Mice, Inbred C57BL; Nuclear Receptor Subfamily 1, Group F, Member 3; Ophthalmic Solutions; Phenylalanine; Piperidines; Real-Time Polymerase Chain Reaction; RNA, Messenger; Sjogren's Syndrome; Staining and Labeling; Thrombospondin 1	2016
Estrogen's Effects on Excitatory Synaptic Transmission Entail Integrin and TrkB Transactivation and Depend Upon β1-integrin function. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016, Volume: 41, Issue:11 Topics: Animals; Animals, Newborn; Benzodioxoles; Dipeptides; Disks Large Homolog 4 Protein; Estrogen Receptor Modulators; Estrogens; Excitatory Postsynaptic Potentials; Female; Gene Expression Regulation; Guanylate Kinases; Hippocampus; Integrin beta1; Integrins; Male; Matrix Metalloproteinase Inhibitors; Membrane Proteins; Mice, Knockout; Neurons; Phenylalanine; Piperidines; Pyrazoles; Pyrimidines; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Thiophenes	2016
The impact of β-azido(or 1-piperidinyl)methylamino acids in position 2 or 3 on biological activity and conformation of dermorphin analogues. Journal of peptide science : an official publication of the European Peptide Society, 2016, Volume: 22, Issue:8 Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Analgesics, Opioid; Animals; Azides; Binding Sites; Binding, Competitive; Brain Chemistry; Cell Membrane; Drug Design; Ligands; Molecular Dynamics Simulation; Opioid Peptides; Phenylalanine; Piperidines; Protein Binding; Protein Structure, Secondary; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship	2016
Biomedical Informatics Approaches to Identifying Drug-Drug Interactions: Application to Insulin Secretagogues. Epidemiology (Cambridge, Mass.), 2017, Volume: 28, Issue:3 Topics: Area Under Curve; Carbamates; Cyclohexanes; Databases, Factual; Diabetes Mellitus, Type 2; Drug Interactions; Glipizide; Glyburide; Humans; Hypoglycemia; Hypoglycemic Agents; Medical Informatics; Nateglinide; Pharmacoepidemiology; Phenylalanine; Piperidines; Sulfonylurea Compounds	2017
2017 New Drug Update. The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists, 2017, May-01, Volume: 32, Issue:5 Topics: Anti-Inflammatory Agents; Antipsychotic Agents; Drugs, Investigational; Dry Eye Syndromes; Gout Suppressants; Humans; Hypoglycemic Agents; Insulin, Long-Acting; Peptides; Phenylalanine; Piperidines; Sulfones; Thioglycolates; Triazoles; Urea	2017
New Drugs 2020, part 1. Nursing, 2020, Volume: 50, Issue:2 Topics: Antibodies, Monoclonal; Benzofurans; Carbamates; Drug Approval; Humans; Phenylalanine; Piperidines; Purines; Tetracyclines; United States; United States Food and Drug Administration	2020
Pitolisant, a wake-promoting agent devoid of psychostimulant properties: Preclinical comparison with amphetamine, modafinil, and solriamfetol. Pharmacology research & perspectives, 2021, Volume: 9, Issue:5 Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Uptake Inhibitors; Amphetamine; Animals; Carbamates; Corpus Striatum; Disorders of Excessive Somnolence; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Drug Evaluation, Preclinical; Drug Inverse Agonism; Feeding Behavior; Histamine Antagonists; Locomotion; Mice; Modafinil; Narcolepsy; Neostriatum; Norepinephrine Plasma Membrane Transport Proteins; Nucleus Accumbens; Phenylalanine; Piperidines; Receptors, Histamine H3; Sleep Apnea, Obstructive; Wakefulness-Promoting Agents	2021