phenylalanine has been researched along with pf-3450074 in 22 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 16 (72.73) | 24.3611 |
| 2020's | 6 (27.27) | 2.80 |
| Authors | Studies |
|---|---|
| Aiken, C; Shah, VB; Shi, J; Whitby, K; Zhou, J | 1 |
| Chin, JW; Elliott, T; Fletcher, AJ; James, LC; KewalRamani, VN; Lee, K; Price, AJ; Schaller, T; Towers, GJ | 1 |
| Aiken, C; Blair, WS; Burse, MJ; Butler, SL; Halambage, UD; Shah, VB; Shi, J; Wu, H; Zhou, J | 1 |
| Aiken, C; Chin, JW; Essig, S; Fletcher, AJ; Halambage, UD; Jacques, DA; James, LC; McEwan, WA; Price, AJ | 1 |
| Cihlar, T; Glass, B; Kräusslich, HG; Laketa, V; Müller, B; Muranyi, W; Peng, K; Tsai, L; Yant, SR | 1 |
| Alam, SL; Bhattacharya, A; Demeler, B; Diaz-Griffero, F; Fricke, T; Ganser-Pornillos, BK; Ivanov, DN; Pornillos, O; Sedzicki, J; Taylor, AB; Yeager, M; Zadrozny, K | 1 |
| Foley, D; Hope, TJ; Hulme, AE; Kelley, Z | 1 |
| Chou, C; Clancy, S; Halcomb, R; Hu, E; Hung, M; Jin, D; Koditek, D; Lad, L; Niedziela-Majka, A; Pagratis, N; Papalia, GA; Sakowicz, R; Somoza, JR; Tse, W; Wong, MH; Yant, S | 1 |
| Aiken, C; Halambage, UD; James, LC; Price, AJ; Zhou, J | 1 |
| Aiken, C; Engelman, AN; Ferhadian, D; Halambage, UD; Saito, A; Serrao, E; Shi, J; Siddiqui, MA; Soto, J; Sowd, GA; Teng, S; Yamashita, M | 1 |
| Aggarwal, A; Böcking, T; Jacques, DA; Lau, D; Márquez, CL; McGuinness, C; Parker, MW; Shah, V; Turville, S; Walsh, J; Wong, A | 1 |
| Aiken, C; Ramalho, R; Rankovic, S; Rousso, I | 1 |
| Addai, A; Aiken, C; Balasubramaniam, M; Dash, C; Martinez, P; Pandhare, J; Zhou, J | 1 |
| Bejarano, DA; Börner, K; Glass, B; Jost, KL; Kräusslich, HG; Laketa, V; Lucic, B; Lusic, M; Müller, B; Peng, K | 1 |
| Aiken, C; Ambrose, Z; Ferhadian, D; Fischer, DK; Francis, AC; Halambage, UD; Melikyan, GB; Saito, A; Siddiqui, MA; Yamashita, M | 1 |
| Grime, JMA; Pak, AJ; Voth, GA; Yu, A | 1 |
| Casey, MC; Do, HT; Du, H; Hachiya, A; Kirby, KA; Sahani, RL; Sarafianos, SG; Tedbury, PR; Vernekar, SKV; Wang, L; Wang, Z; Xie, J; Zhang, H | 1 |
| Bachmann, N; Campbell, EM; Dharan, A; Talley, S; Zwikelmaier, V | 1 |
| Chen, L; Feng, Y; Hou, W; Hu, H; Ju, Z; Wang, J; Wang, M; Xie, L; Xiong, H; Yu, T; Zeng, Y; Zhong, C | 1 |
| Harrison, L; Peacock, TP; Spencer, M; Sumner, RP; Touizer, E; Towers, GJ; Zuliani-Alvarez, L | 1 |
| Avelar, L; Becker, D; Gohlke, H; Häussinger, D; Kurz, T; Münk, C; Pflieger, M; Scheck, R; Twizerimana, AP; Wammers, M; Zhang, Z | 1 |
| Casey, MC; Castaner, AE; Diana-Rivero, R; Du, H; Kirby, KA; Sahani, RL; Sarafianos, SG; Tedbury, PR; Vernekar, SKV; Wang, L; Wang, Z; Xie, J; Zhang, H | 1 |
22 other study(ies) available for phenylalanine and pf-3450074
| Article | Year |
|---|---|
Small-molecule inhibition of human immunodeficiency virus type 1 infection by virus capsid destabilization.
Topics: Animals; Anti-HIV Agents; Capsid; Capsid Proteins; Cell Line; Cyclophilin A; HeLa Cells; HIV-1; Humans; Indoles; Phenylalanine; Reverse Transcription; Virion; Virus Assembly | 2011 |
CPSF6 defines a conserved capsid interface that modulates HIV-1 replication.
Topics: Amino Acid Sequence; Antiviral Agents; beta Karyopherins; Capsid Proteins; Cell Line, Tumor; Conserved Sequence; Crystallography, X-Ray; HIV Infections; HIV-1; Humans; Indoles; Models, Molecular; Molecular Chaperones; Molecular Sequence Data; mRNA Cleavage and Polyadenylation Factors; Mutation; Nuclear Pore Complex Proteins; Phenylalanine; Protein Binding; Sequence Alignment; Virus Internalization; Virus Replication | 2012 |
Compensatory substitutions in the HIV-1 capsid reduce the fitness cost associated with resistance to a capsid-targeting small-molecule inhibitor.
Topics: Amino Acid Substitution; Anti-HIV Agents; Cells, Cultured; Drug Resistance, Viral; HIV Core Protein p24; HIV-1; Humans; Indoles; Macrophages; Mutant Proteins; Mutation, Missense; Phenylalanine; Selection, Genetic; Suppression, Genetic; Virus Replication | 2015 |
Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly.
Topics: Anti-HIV Agents; Binding Sites; Capsid; Capsid Proteins; HIV Infections; HIV-1; Humans; Indoles; Ligands; Models, Molecular; Models, Structural; mRNA Cleavage and Polyadenylation Factors; Mutation; Nuclear Pore Complex Proteins; Phenylalanine; Polycyclic Compounds; Polymerization; Protein Binding; Protein Structure, Tertiary; Reverse Transcription; Virion | 2014 |
Quantitative microscopy of functional HIV post-entry complexes reveals association of replication with the viral capsid.
Topics: Active Transport, Cell Nucleus; beta Karyopherins; Capsid Proteins; Cell Line, Tumor; Cell Nucleus; Cytosol; DNA, Viral; Gene Expression Regulation; HEK293 Cells; HeLa Cells; HIV Integrase; HIV-1; Host-Pathogen Interactions; Humans; Indoles; Macrophages; Microscopy, Confocal; mRNA Cleavage and Polyadenylation Factors; Phenylalanine; Primary Cell Culture; Reverse Transcription; Signal Transduction; T-Lymphocytes; Virus Integration; Virus Internalization; Virus Replication | 2014 |
Structural basis of HIV-1 capsid recognition by PF74 and CPSF6.
Topics: Capsid; Crystallography, X-Ray; HIV Infections; HIV-1; Indoles; mRNA Cleavage and Polyadenylation Factors; Nuclear Pore Complex Proteins; Phenylalanine; Protein Binding | 2014 |
Complementary Assays Reveal a Low Level of CA Associated with Viral Complexes in the Nuclei of HIV-1-Infected Cells.
Topics: Anti-HIV Agents; Capsid; Cell Line; Cell Nucleus; HEK293 Cells; HeLa Cells; HIV Core Protein p24; HIV Infections; HIV-1; Humans; Indoles; Phenylalanine; Virus Replication; Virus Uncoating | 2015 |
Functional label-free assays for characterizing the in vitro mechanism of action of small molecule modulators of capsid assembly.
Topics: Amino Acid Sequence; Anti-HIV Agents; Benzimidazoles; Biosensing Techniques; Capsid; Drug Evaluation, Preclinical; HIV-1; Host-Pathogen Interactions; Indoles; Molecular Sequence Data; mRNA Cleavage and Polyadenylation Factors; Phenylalanine; Recombinant Proteins; Small Molecule Libraries | 2015 |
HIV-1 Resistance to the Capsid-Targeting Inhibitor PF74 Results in Altered Dependence on Host Factors Required for Virus Nuclear Entry.
Topics: Amino Acid Substitution; Anti-HIV Agents; beta Karyopherins; Binding Sites; Capsid; Capsid Proteins; CD4-Positive T-Lymphocytes; Cell Line; Drug Resistance, Viral; HIV Infections; HIV-1; Host-Pathogen Interactions; Humans; Indoles; Macrophages; Molecular Chaperones; mRNA Cleavage and Polyadenylation Factors; Nuclear Pore Complex Proteins; Phenylalanine; Protein Binding; Protein Conformation; RNA Interference; RNA, Small Interfering; Virus Internalization; Virus Replication | 2015 |
Roles of Capsid-Interacting Host Factors in Multimodal Inhibition of HIV-1 by PF74.
Topics: Anti-HIV Agents; Binding Sites; Capsid; Capsid Proteins; Cyclophilin A; HEK293 Cells; HeLa Cells; HIV-1; Host-Pathogen Interactions; Humans; Indoles; mRNA Cleavage and Polyadenylation Factors; Nuclear Pore Complex Proteins; Phenylalanine; Reverse Transcription; Virus Replication | 2016 |
Kinetics of HIV-1 capsid uncoating revealed by single-molecule analysis.
Topics: Capsid; Capsid Proteins; Cyclophilin A; HEK293 Cells; HeLa Cells; HIV-1; Humans; Indoles; Kinetics; Microscopy, Fluorescence; Phenylalanine; Protein Binding; Reverse Transcription; Time-Lapse Imaging; Virion | 2018 |
PF74 Reinforces the HIV-1 Capsid To Impair Reverse Transcription-Induced Uncoating.
Topics: Antiviral Agents; Capsid; HIV-1; Indoles; Microscopy, Atomic Force; Phenylalanine; Protein Binding; Reverse Transcription; Virus Uncoating | 2018 |
PF74 Inhibits HIV-1 Integration by Altering the Composition of the Preintegration Complex.
Topics: Anti-HIV Agents; Capsid; Capsid Proteins; Cell Line; DNA, Viral; HEK293 Cells; HIV Infections; HIV Seropositivity; HIV-1; Humans; Indoles; Phenylalanine; Reverse Transcription; Virus Integration; Virus Replication | 2019 |
HIV-1 nuclear import in macrophages is regulated by CPSF6-capsid interactions at the nuclear pore complex.
Topics: Active Transport, Cell Nucleus; Capsid; Cell Nucleus; HeLa Cells; HIV-1; Humans; Indoles; Intercellular Signaling Peptides and Proteins; Macrophages; mRNA Cleavage and Polyadenylation Factors; Nuclear Pore Complex Proteins; Phenylalanine; Virus Internalization; Virus Replication | 2019 |
A Novel Phenotype Links HIV-1 Capsid Stability to cGAS-Mediated DNA Sensing.
Topics: Amino Acid Sequence; Anti-HIV Agents; Capsid; Capsid Proteins; Cell Line, Tumor; Disease Resistance; DNA, Viral; HIV Infections; HIV-1; Host-Pathogen Interactions; Humans; Indoles; Mutation; Nucleotidyltransferases; Phenylalanine; Protein Stability | 2019 |
Off-Pathway Assembly: A Broad-Spectrum Mechanism of Action for Drugs That Undermine Controlled HIV-1 Viral Capsid Formation.
Topics: Anti-HIV Agents; Capsid; Capsid Proteins; HIV-1; Humans; Indazoles; Indoles; Molecular Dynamics Simulation; Phenylalanine; Pyridines; Virus Replication | 2019 |
Chemical profiling of HIV-1 capsid-targeting antiviral PF74.
Topics: Animals; Anti-HIV Agents; Capsid Proteins; Cell Line; Dose-Response Relationship, Drug; HIV-1; Humans; Indoles; Mice; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Phenylalanine; Structure-Activity Relationship; Virus Replication | 2020 |
Nuclear pore blockade reveals that HIV-1 completes reverse transcription and uncoating in the nucleus.
Topics: Active Transport, Cell Nucleus; Capsid; Capsid Proteins; CD4-Positive T-Lymphocytes; Cell Nucleus; Cytoplasm; HEK293 Cells; HeLa Cells; HIV Infections; HIV-1; Host-Pathogen Interactions; Humans; Indoles; Macrophages; Nuclear Pore; Phenylalanine; Reverse Transcription; Virus Replication | 2020 |
MxB impedes the NUP358-mediated HIV-1 pre-integration complex nuclear import and viral replication cooperatively with CPSF6.
Topics: Active Transport, Cell Nucleus; Capsid; Capsid Proteins; Cell Nucleus; HIV-1; Humans; Indoles; Molecular Chaperones; mRNA Cleavage and Polyadenylation Factors; Myxovirus Resistance Proteins; Nuclear Pore Complex Proteins; Phenylalanine; Protein Binding; Virus Replication | 2020 |
Disrupting HIV-1 capsid formation causes cGAS sensing of viral DNA.
Topics: Adaptive Immunity; Antiviral Restriction Factors; Capsid; Cell Line; CRISPR-Cas Systems; DNA, Viral; Gene Editing; Gene Products, gag; HIV Infections; HIV Protease Inhibitors; HIV-1; Host-Pathogen Interactions; Humans; Immunity, Innate; Indoles; Interferons; Macrophages; Membrane Proteins; Mutation; Nucleotidyltransferases; Phenylalanine; Signal Transduction; Tripartite Motif Proteins; Ubiquitin-Protein Ligases; Virus Replication | 2020 |
Cell Type-Dependent Escape of Capsid Inhibitors by Simian Immunodeficiency Virus SIVcpz.
Topics: Animals; Anti-HIV Agents; Binding Sites; Capsid; Capsid Proteins; Cell Line; Cyclophilin A; Gene Knockout Techniques; HEK293 Cells; HeLa Cells; HIV-1; Humans; Indazoles; Indoles; Leukocytes, Mononuclear; Macrophages; Models, Molecular; mRNA Cleavage and Polyadenylation Factors; Pan troglodytes; Phenylalanine; Protein Conformation; Protein Interaction Domains and Motifs; Pyridines; Sequence Alignment; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Zoonoses | 2020 |
Design, Synthesis and Characterization of HIV-1 CA-Targeting Small Molecules: Conformational Restriction of PF74.
Topics: Animals; Anti-HIV Agents; Binding Sites; Capsid Proteins; Cell Line; Drug Design; HEK293 Cells; HIV-1; Humans; Indoles; Liver; Mice; Microsomes; Models, Molecular; Molecular Conformation; Phenylalanine; Small Molecule Libraries; Virus Replication | 2021 |