phenylalanine and naloxone

phenylalanine has been researched along with naloxone in 57 studies

Research

Studies (57)

TimeframeStudies, this research(%)All Research%
pre-199024 (42.11)18.7374
1990's23 (40.35)18.2507
2000's8 (14.04)29.6817
2010's2 (3.51)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bellman, K; Knegtel, RM; Settimo, L1
Bhargava, HN1
Fournié-Zaluski, MC; Noble, F; Roques, BP; Turcaud, S1
Coric, P; Fournié-Zaluski, MC; Noble, F; Roques, BP1
Fournie-Zaluski, MC; Noble, F; Roques, BP; Soleilhac, JM; Soroca-Lucas, E; Turcaud, S1
Fournié-Zaluski, MC; Maldonado, R; Roques, BP1
Fournié-Zaluski, MC; Noble, F; Peyroux, J; Roques, BP; Schmidt, C1
Panocka, I; Sadowski, B1
Feger, J; Maldonado, R; Roques, BP; Waksman, G1
Feger, J; Fournié-Zaluski, MC; Maldonado, R; Roques, BP1
Dygai, AM; Goldberg, ED; Shakhov, VP; Zakharova, O1
Carlson, HE1
Callebert, J; Daugé, V; Feger, J; Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Villette, JM1
Herblin, WF; Kauer, JC; Tam, SW1
Lebedev, VP; Petriaevskaia, NV; Savchenko, AB1
Takeshige, C1
Hyodo, M; Ikeuchi, T; Kawachi, A; Kitade, T; Minamikawa, M; Morikawa, K; Odahara, Y; Sakai, T; Shinohara, S; Toyota, S1
Ehrenpreis, S1
Gianoulakis, C; Gupta, A1
Kimura, H; Mapelli, C; Stammer, CH1
Dong, WK; Halpern, LM1
Cohen, S; Ouyang, A; Reynolds, JC1
Sarne, Y; Segev, S; Urca, G1
Albonetti, ME; D'Udine, B; Oliverio, A1
Hosoya, E; Nozaki, M; Oka, T1
Collier, HO; Francis, DL; Schneider, C1
Ho, IK; Loh, HH; Lu, SE; Stolman, S; Way, EL1
Duggan, AW; Foong, FW; Zhao, ZQ1
Kubota, K; Natsuoka, Y; Sakuma, M; Uruno, T1
Bodnar, RJ; Butler, PD1
Stone, TW1
Eshel, Y; Keren, O; Korczyn, AD1
Cheng, RSS; Pomeranz, B1
Barrett, GD; Mitchell, D; Woolf, CJ1
Gibert-Rahola, J; Maldonado, R; Mico, JA; Roques, BP; Tejedor-Real, P1
Kaliuzhnyĭ, LV; Kozlov, AIu; Litvinova, SV; Shul'govskiĭ, VV1
Blommaert, A; Fournié-Zaluski, MC; Noble, F; Roques, BP1
Blommaert, AG; Ducos, B; Fournie-Zaluski, MC; Maldonado, R; Roques, BP; Valverde, O1
Fournié-Zaluski, MC; Noble, F; Roques, BP2
Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Turcaud, S; Valverde, O1
Noble, F; Roques, BP; Smadja, C1
Coric, P; Fournié-Zaluski, MC; Noble, F; Roques, BP; Turcaud, S1
Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Ruiz, F1
Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Valverde, O1
Fournié-Zaluski, MC; Fuentes, JA; Hernando, F; Roques, BP; Ruiz-Gayo, M1
Carp, HM; Fournié-Zaluski, MC; Jayaram, A; Noreuil, T; Singh, P1
Chover-Gonzalez, AJ; Fournié-Zaluski, MC; Gibert-Rahola, J; Lai-Kuen, R; Maldonado, R; Mico, JA; Ortega-Alvaro, A; Roques, BP1
Boudinot, E; Denavit-Saubié, M; Fournié-Zaluski, M; Foutz, AS; Morin-Surun, M; Roques, BP1
Boucher, M; Coudoré-Civiale, MA; Eschalier, A; Fournié-Zaluski, MC; Méen, M; Roques, BP1
Besson, JM; Buritova, J; Fournié-Zaluski, MC; Le Guen, S; Roques, BP1
Barnes, TA; Calo, G; Carra, G; Guerrini, R; Kitayama, M; Lambert, DG; McDonald, J; Rowbotham, DJ; Smith, G1
Eisinger, DA; Schulz, R; Wehmeyer, A1
Cordonnier, L; Noble, F; Roques, BP; Sanchez, M1
Guen, SL; Kieffer, BL; Nieto, MM; Noble, F; Roques, BP1
Benturquia, N; Bilkei-Gorzo, A; Noble, F; Roques, BP; Zimmer, A1
Hurlé, MA; Lantero, A; Pílar-Cuellar, F; Roques, BP; Santillán, R; Tramullas, M; Valdizán, E1

Reviews

1 review(s) available for phenylalanine and naloxone

ArticleYear
[Enkephalinase mechanisms of tolerance of analgetic action of opioids. Effects of D-phenylalanine and naloxone].
    Vestnik Rossiiskoi akademii meditsinskikh nauk, 1994, Issue:10

    Topics: Animals; Drug Resistance; Drug Tolerance; Mice; Morphine; Naloxone; Neprilysin; Opioid Peptides; Phenylalanine; Rabbits; Rats; Rats, Wistar

1994

Other Studies

56 other study(ies) available for phenylalanine and naloxone

ArticleYear
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
Studies of the possible role of brain endorphins in pentobarbital anesthesia and toxicity in mice.
    Anesthesiology, 1979, Volume: 51, Issue:5

    Topics: Animals; Brain; Endorphins; Enkephalins; Leucine; Male; Mice; Morphine; Naloxone; Naltrexone; Pentobarbital; Phenylalanine

1979
Repeated systemic administration of the mixed inhibitor of enkephalin-degrading enzymes, RB101, does not induce either antinociceptive tolerance or cross-tolerance with morphine.
    European journal of pharmacology, 1992, Nov-13, Volume: 223, Issue:1

    Topics: Analgesics; Animals; Disulfides; Dose-Response Relationship, Drug; Drug Tolerance; Indoles; Male; Mice; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Phenylalanine; Prodrugs; Reaction Time

1992
Lack of physical dependence in mice after repeated systemic administration of the mixed inhibitor prodrug of enkephalin-degrading enzymes, RB101.
    European journal of pharmacology, 1992, Nov-13, Volume: 223, Issue:1

    Topics: Animals; Behavior, Animal; Body Weight; Disulfides; Injections, Intraventricular; Male; Mice; Morphine; Naloxone; Phenylalanine; Prodrugs; Substance Withdrawal Syndrome; Substance-Related Disorders

1992
Inhibition of the enkephalin-metabolizing enzymes by the first systemically active mixed inhibitor prodrug RB 101 induces potent analgesic responses in mice and rats.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 261, Issue:1

    Topics: Aminopeptidases; Analgesia; Analgesics; Animals; Cell Membrane; Chromatography, High Pressure Liquid; Disulfides; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Inhibitors; Injections, Intravenous; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Naloxone; Neprilysin; Phenylalanine; Prodrugs; Rats; Rats, Inbred Strains

1992
Attenuation of the morphine withdrawal syndrome by inhibition of catabolism of endogenous enkephalins in the periaqueductal gray matter.
    Naunyn-Schmiedeberg's archives of pharmacology, 1992, Volume: 345, Issue:4

    Topics: Analgesics; Animals; Behavior, Animal; Body Temperature; Body Weight; Corticosterone; Dipeptides; Enkephalins; Hydroxamic Acids; Male; Morphine; Morphine Dependence; Naloxone; Neprilysin; Periaqueductal Gray; Phenylalanine; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Thiorphan

1992
Analgesic responses elicited by endogenous enkephalins (protected by mixed peptidase inhibitors) in a variety of morphine-sensitive noxious tests.
    European journal of pharmacology, 1991, Jan-10, Volume: 192, Issue:2

    Topics: Analgesics; Animals; Dipeptides; Dose-Response Relationship, Drug; Enkephalins; Hydroxamic Acids; Male; Mice; Morphine; Naloxone; Phenylalanine; Rats; Rats, Inbred Strains

1991
Potentiation of swim analgesia by D-amino acids in mice is genotype dependent.
    Pharmacology, biochemistry, and behavior, 1990, Volume: 37, Issue:4

    Topics: Amino Acids; Analgesia; Animals; Female; Genotype; Leucine; Male; Mice; Mice, Inbred Strains; Naloxone; Pain Measurement; Phenylalanine; Reaction Time; Swimming

1990
Naloxone-induced withdrawal syndrome after administration of selective opioid agonists or after activation of the endogenous enkephalinergic system.
    Progress in clinical and biological research, 1990, Volume: 328

    Topics: Animals; Behavior, Animal; Body Temperature; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hydroxamic Acids; Naloxone; Narcotics; Oligopeptides; Phenylalanine; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Weight Loss

1990
Differences in physical dependence induced by selective mu or delta opioid agonists and by endogenous enkephalins protected by peptidase inhibitors.
    Brain research, 1990, Jun-18, Volume: 520, Issue:1-2

    Topics: Animals; Cerebral Ventricles; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hydroxamic Acids; Injections, Intraventricular; Male; Naloxone; Neprilysin; Oligopeptides; Phenylalanine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Reference Values; Substance Withdrawal Syndrome; Substance-Related Disorders

1990
The modulating influence of enkephalins on the bone marrow haemopoiesis in stress.
    Folia biologica, 1990, Volume: 36, Issue:6

    Topics: Animals; Bone Marrow; Cell Count; Cell Differentiation; Cell Division; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Hematopoiesis; Male; Mice; Naloxone; Phenylalanine; Restraint, Physical; Stress, Physiological; Time Factors

1990
Prolactin stimulation by protein is mediated by amino acids in humans.
    The Journal of clinical endocrinology and metabolism, 1989, Volume: 69, Issue:1

    Topics: Adult; Dietary Proteins; Dose-Response Relationship, Drug; Female; Humans; Male; Naloxone; Phenylalanine; Prolactin; Sex Factors; Time Factors; Tyrosine; Vagotomy

1989
Comparison of selective and complete inhibitors of enkephalin-degrading enzymes on morphine withdrawal syndrome.
    European journal of pharmacology, 1989, Jun-20, Volume: 165, Issue:2-3

    Topics: Animals; Behavior, Animal; Body Temperature; Body Weight; Corticosterone; Dipeptides; Hydroxamic Acids; Injections, Intraventricular; Male; Morphine Dependence; Naloxone; Neprilysin; Phenylalanine; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Thiorphan

1989
Photoinactivation of the mu opioid receptor using a novel synthetic morphiceptin analog.
    European journal of pharmacology, 1987, Jul-23, Volume: 139, Issue:3

    Topics: Affinity Labels; Animals; Brain; Chemical Phenomena; Chemistry; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guinea Pigs; In Vitro Techniques; Light; Naloxone; Phenylalanine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu

1987
[The opiate mechanism of transcranial electroanalgesia in rats and mice].
    Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova, 1988, Volume: 74, Issue:9

    Topics: Animals; Drug Tolerance; Electronarcosis; Endorphins; Leucine; Male; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Phenylalanine; Rats; Rats, Inbred Strains; Receptors, Opioid

1988
Differentiation between acupuncture and non-acupuncture points by association with analgesia inhibitory system.
    Acupuncture & electro-therapeutics research, 1985, Volume: 10, Issue:3

    Topics: Acupuncture Therapy; Animals; Brain; Dexamethasone; Electric Stimulation; Evoked Potentials; Hypothalamus, Posterior; Morphine; Naloxone; Neural Inhibition; Nociceptors; Periaqueductal Gray; Phenylalanine; Pituitary Gland; Rabbits; Rats; Rats, Inbred Strains; Sensory Thresholds; Thalamic Nuclei

1985
Studies on the enhanced effect of acupuncture analgesia and acupuncture anesthesia by D-phenylalanine (first report)--effect on pain threshold and inhibition by naloxone.
    Acupuncture & electro-therapeutics research, 1988, Volume: 13, Issue:2-3

    Topics: Acupuncture Therapy; Adult; Analgesia; Anesthesia; Double-Blind Method; Female; Humans; Male; Naloxone; Pain; Phenylalanine; Placebos; Receptors, Opioid; Sensory Thresholds

1988
Analgesic properties of enkephalinase inhibitors: animal and human studies.
    Progress in clinical and biological research, 1985, Volume: 192

    Topics: Acupuncture Therapy; Analgesia; Analgesics; Animals; Bacitracin; beta-Endorphin; Brain; Drug Synergism; Endorphins; Enkephalin, Methionine; Humans; Kinetics; Mice; Naloxone; Neprilysin; Pain, Intractable; Phenylalanine; Protease Inhibitors; Puromycin; Stereoisomerism

1985
Neurointermediate lobe transplanted under the kidney capsule modifies the activity of the neurointermediate lobe in situ, but does not respond to opiate treatment.
    Canadian journal of physiology and pharmacology, 1986, Volume: 64, Issue:4

    Topics: Animals; beta-Endorphin; beta-Lipotropin; Endorphins; Histocytochemistry; Kidney; Kinetics; Male; Morphine; Naloxone; Phenylalanine; Pituitary Gland; Pro-Opiomelanocortin; Rats; Rats, Inbred Strains

1986
Synthesis of four diastereomeric enkephalins incorporating cyclopropyl phenylalanine.
    International journal of peptide and protein research, 1986, Volume: 28, Issue:4

    Topics: Animals; Binding, Competitive; Brain; Circular Dichroism; Cyclopropanes; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Indicators and Reagents; Male; Naloxone; Phenylalanine; Protein Conformation; Rats; Rats, Inbred Strains; Receptors, Opioid; Stereoisomerism; Structure-Activity Relationship

1986
D-phenylalanine: a putative enkephalinase inhibitor studied in a primate acute pain model.
    Pain, 1986, Volume: 24, Issue:2

    Topics: Animals; Aspirin; Avoidance Learning; Carboxypeptidases; Drug Interactions; Isomerism; Macaca fascicularis; Male; Morphine; Naloxone; Neprilysin; Pain; Phenylalanine; Protease Inhibitors; Sensory Thresholds; Tolmetin

1986
Opiate nerves mediate feline pyloric response to intraduodenal amino acids.
    The American journal of physiology, 1985, Volume: 248, Issue:3 Pt 1

    Topics: Amino Acids; Animals; Cats; Duodenum; Endorphins; Gastrointestinal Motility; Naloxone; Neural Pathways; Phenylalanine; Pylorus; Sincalide; Stimulation, Chemical; Tryptophan

1985
Footshock-induced analgesia: its opioid nature depends on the strain of rat.
    Brain research, 1985, Mar-11, Volume: 329, Issue:1-2

    Topics: Analgesia; Animals; Electroshock; Endorphins; Foot; Naloxone; Pain; Periaqueductal Gray; Phenylalanine; Rats; Rats, Inbred Strains; Rats, Inbred WKY; Species Specificity

1985
D-Amino acids influence ultrasonic calling in mice pups: effects of D-phenylalanine and D-leucine.
    Neuroscience letters, 1985, Jun-24, Volume: 57, Issue:3

    Topics: Animals; Animals, Newborn; Anxiety, Separation; Drug Therapy, Combination; Endorphins; Humans; Leucine; Mice; Naloxone; Object Attachment; Phenylalanine; Ultrasonics; Vocalization, Animal

1985
Effects of p-chlorophenylalanine and cholinergic antagonists on body temperature changes induced by the administration of morphine to nontolerant and morphine-tolerant rats.
    The Journal of pharmacology and experimental therapeutics, 1972, Volume: 180, Issue:1

    Topics: Animals; Atropine; Body Temperature; Drug Tolerance; Fenclonine; Male; Methyltyrosines; Morphine; Naloxone; Phenylalanine; Rats; Rats, Inbred Strains; Scopolamine; Serotonin; Sympathomimetics; Time Factors

1972
Modification of morphine withdrawal by drugs interacting with humoral mechanisms: some contradictions and their interpretation.
    Nature, 1972, May-26, Volume: 237, Issue:5352

    Topics: Animals; Atropine; Behavior, Animal; Drug Interactions; Fenclonine; Heroin; Humans; Indomethacin; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morphine; Motor Activity; Naloxone; Phenylalanine; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Time Factors

1972
Influence of p-chlorophenylalanine on morphine tolerance and physical dependence and regional brain serotonin turnover studies in morphine tolerant-dependent mice.
    The Journal of pharmacology and experimental therapeutics, 1972, Volume: 182, Issue:1

    Topics: Analgesia; Animals; Body Weight; Brain Chemistry; Brain Stem; Drug Tolerance; Fenclonine; Humans; Hypothalamus; Male; Mice; Mice, Inbred Strains; Morphine; Morphine Dependence; Naloxone; Pargyline; Phenylalanine; Rats; Rats, Inbred Strains; Serotonin; Substance Withdrawal Syndrome; Time Factors

1972
Lack of interaction between methionine enkephalin and D-phenylalanine on nociceptive and non-nociceptive responses of dorsal horn neurones of the cat.
    European journal of pharmacology, 1984, Sep-17, Volume: 104, Issue:3-4

    Topics: Analgesia; Animals; Cats; Drug Interactions; Enkephalin, Methionine; Naloxone; Neurons; Pain; Phenylalanine; Receptors, Opioid; Reflex; Spinal Cord

1984
Characteristics of analgesia induced by noncatecholic phenylethylamine derivatives: possible involvement of endogenous opioid peptides and serotonin in phenylethylamine analog-induced analgesia.
    Japanese journal of pharmacology, 1984, Volume: 34, Issue:3

    Topics: 2-Hydroxyphenethylamine; Amphetamine; Analgesics; Animals; Drug Interactions; Endorphins; Fenclonine; Male; Methysergide; Mice; Naloxone; Pargyline; Phenethylamines; Phenylalanine; Reserpine; Serotonin

1984
Modulation of deprivation-induced food intake by D-phenylalanine.
    The International journal of neuroscience, 1983, Volume: 20, Issue:3-4

    Topics: Animals; Dose-Response Relationship, Drug; Eating; Female; Food Deprivation; Hunger; Naloxone; Phenylalanine; Rats; Rats, Inbred Strains; Receptors, Opioid

1983
A comparison of the effects of morphine, enkephalin, kyotorphin and D-phenylalanine on rat central neurones.
    British journal of pharmacology, 1983, Volume: 79, Issue:1

    Topics: Animals; Brain; Cerebral Cortex; Endorphins; Enkephalin, Methionine; Globus Pallidus; Iontophoresis; Male; Morphine; Naloxone; Neurons; Phenylalanine; Rats

1983
Enkephalin mydriasis in mice.
    European journal of pharmacology, 1980, Jul-25, Volume: 65, Issue:2-3

    Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Mydriatics; Naloxone; Phenylalanine

1980
A combined treatment with D-amino acids and electroacupuncture produces a greater analgesia than either treatment alone; naloxone reverses these effects.
    Pain, 1980, Volume: 8, Issue:2

    Topics: Acupuncture Therapy; Analgesia; Animals; Electric Stimulation; Female; Leucine; Mice; Naloxone; Pain Management; Phenylalanine

1980
Antinociceptive effect of peripheral segmental electrical stimulation in the rat.
    Pain, 1980, Volume: 8, Issue:2

    Topics: Animals; Electric Stimulation; Male; Morphine; Naloxone; Nociceptors; Phenylalanine; Rats; Reaction Time; Serotonin; Thoracic Surgery

1980
Implication of endogenous opioid system in the learned helplessness model of depression.
    Pharmacology, biochemistry, and behavior, 1995, Volume: 52, Issue:1

    Topics: Animals; Antidepressive Agents, Tricyclic; Avoidance Learning; Depression; Electroshock; Endorphins; Enkephalins; Helplessness, Learned; Hydroxamic Acids; Imipramine; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Neprilysin; Phenylalanine; Protease Inhibitors; Rats; Rats, Wistar

1995
A selective CCKB receptor antagonist potentiates, mu-, but not delta-opioid receptor-mediated antinociception in the formalin test.
    European journal of pharmacology, 1995, Jan-24, Volume: 273, Issue:1-2

    Topics: Analgesics; Animals; Disulfides; Enkephalins; Formaldehyde; Indoles; Male; Meglumine; Mice; Morphine; Naloxone; Naltrexone; Pain Measurement; Phenylalanine; Receptors, Cholecystokinin; Receptors, Opioid, delta; Receptors, Opioid, mu

1995
Inhibition of morphine withdrawal by the association of RB 101, an inhibitor of enkephalin catabolism, and the CCKB antagonist PD-134,308.
    British journal of pharmacology, 1995, Volume: 114, Issue:5

    Topics: Analgesics; Animals; Behavior, Animal; Binding, Competitive; Body Temperature; Diprenorphine; Disulfides; Drug Combinations; Drug Synergism; Enkephalins; Indoles; Male; Meglumine; Mice; Morphine; Motor Activity; Naloxone; Phenylalanine; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Substance Withdrawal Syndrome; Weight Loss

1995
Paradoxical analgesia induced by low doses of naloxone is not potentiated by complete inhibition of enkephalin degradation.
    Neuropharmacology, 1994, Volume: 33, Issue:1

    Topics: Abdominal Muscles; Aminopeptidases; Analgesics; Animals; CD13 Antigens; Disulfides; Enkephalins; Male; Mice; Naloxone; Neprilysin; Pain Measurement; Phenylalanine

1994
Antinociceptive response induced by mixed inhibitors of enkephalin catabolism in peripheral inflammation.
    Pain, 1994, Volume: 58, Issue:1

    Topics: Analgesics; Animals; Disulfides; Enkephalins; Hydroxamic Acids; Inflammation; Injections, Intraventricular; Male; Morphine; Naloxone; Narcotic Antagonists; Neprilysin; Pain; Pain Measurement; Phenylalanine; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley

1994
Role of endogenous cholecystokinin in the facilitation of mu-mediated antinociception by delta-opioid agonists.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 271, Issue:3

    Topics: Amino Acid Sequence; Analgesia; Animals; Benzodiazepinones; Cholecystokinin; Devazepide; Disulfides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Molecular Sequence Data; Naloxone; Naltrexone; Oligopeptides; Peptide Fragments; Phenylalanine; Receptors, Opioid, delta; Receptors, Opioid, mu; Sincalide

1994
Assessment of physical dependence after continuous perfusion into the rat jugular vein of the mixed inhibitor of enkephalin-degrading enzymes, RB 101.
    European journal of pharmacology, 1994, Mar-03, Volume: 253, Issue:3

    Topics: Analgesics; Animals; Behavior, Animal; Catheterization, Central Venous; Disulfides; Enzyme Inhibitors; Injections, Subcutaneous; Male; Morphine Dependence; Naloxone; Phenylalanine; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Substance-Related Disorders

1994
Unlike morphine the endogenous enkephalins protected by RB101 are unable to establish a conditioned place preference in mice.
    European journal of pharmacology, 1993, Jan-12, Volume: 230, Issue:2

    Topics: Animals; Conditioning, Operant; Disulfides; Drug Interactions; Enkephalins; Enzyme Inhibitors; Male; Mice; Morphine; Naloxone; Phenylalanine; Prodrugs; Substance-Related Disorders

1993
Similar decrease in spontaneous morphine abstinence by methadone and RB 101, an inhibitor of enkephalin catabolism.
    British journal of pharmacology, 1996, Volume: 119, Issue:1

    Topics: Analgesics; Animals; Disulfides; Drug Combinations; Enkephalins; Indoles; Male; Meglumine; Methadone; Morphine; Naloxone; Phenylalanine; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Substance Withdrawal Syndrome

1996
Similar involvement of several brain areas in the antinociception of endogenous and exogenous opioids.
    European journal of pharmacology, 1996, Sep-19, Volume: 312, Issue:1

    Topics: Analgesia; Analgesics, Opioid; Animals; Brain; Disulfides; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; Opioid Peptides; Phenylalanine; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley

1996
Antidepressant-like effects of CCK(B) receptor antagonists: involvement of the opioid system.
    European journal of pharmacology, 1996, Dec-30, Volume: 318, Issue:2-3

    Topics: Animals; Antidepressive Agents; Benzodiazepinones; Devazepide; Disulfides; Endorphins; Male; Mice; Naloxone; Naltrexone; Phenylalanine; Phenylurea Compounds; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Sincalide

1996
RB 101, a purported pro drug inhibitor of enkephalin metabolism, is antinociceptive in pregnant mice.
    Anesthesia and analgesia, 1997, Volume: 84, Issue:2

    Topics: Analgesics; Analgesics, Opioid; Animals; Depression, Chemical; Disulfides; Enkephalins; Female; Mice; Morphine; Naloxone; Narcotic Antagonists; Pain Threshold; Phenylalanine; Pregnancy; Pregnancy, Animal; Prodrugs; Respiration

1997
Antinociception produced by the peptidase inhibitor, RB 101, in rats with adrenal medullary transplant into the spinal cord.
    European journal of pharmacology, 1998, Sep-04, Volume: 356, Issue:2-3

    Topics: Adrenal Medulla; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Disulfides; Injections, Intravenous; Male; Naloxone; Narcotic Antagonists; Pain; Phentolamine; Phenylalanine; Protease Inhibitors; Rats; Rats, Wistar; Spinal Cord; Subarachnoid Space; Transplantation, Autologous

1998
Effects of the potent analgesic enkephalin-catabolizing enzyme inhibitors RB101 and kelatorphan on respiration.
    Pain, 2001, Feb-01, Volume: 90, Issue:1-2

    Topics: Analgesics; Animals; Cats; Dipeptides; Disulfides; Enkephalins; Enzyme Inhibitors; Mice; Naloxone; Narcotic Antagonists; Phenylalanine; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Respiration

2001
Enhancement of the effects of a complete inhibitor of enkephalin-catabolizing enzymes, RB 101, by a cholecystokinin-B receptor antagonist in diabetic rats.
    British journal of pharmacology, 2001, Volume: 133, Issue:1

    Topics: Aminopeptidases; Animals; Diabetes Mellitus, Experimental; Disulfides; Drug Synergism; Indoles; Male; Meglumine; Naloxone; Naltrexone; Neprilysin; Pain; Pain Measurement; Phenylalanine; Pressure; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Time Factors; Vocalization, Animal; Weight Loss

2001
Antinociceptive effects of RB101(S), a complete inhibitor of enkephalin-catabolizing enzymes, are enhanced by (+)-HA966, a functional NMDA receptor antagonist: a c-Fos study in the rat spinal cord.
    European journal of pain (London, England), 2003, Volume: 7, Issue:3

    Topics: Analgesics; Animals; Carrageenan; Disulfides; Drug Therapy, Combination; Enkephalins; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Immunohistochemistry; Inflammation; Male; Naloxone; Narcotic Antagonists; Pain; Phenylalanine; Proto-Oncogene Proteins c-fos; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord

2003
Pharmacological profile of the cyclic nociceptin/orphanin FQ analogues c[Cys10,14]N/OFQ(1-14)NH2 and c[Nphe1,Cys10,14]N/OFQ(1-14)NH2.
    Naunyn-Schmiedeberg's archives of pharmacology, 2003, Volume: 368, Issue:6

    Topics: Animals; Binding, Competitive; Cell Membrane; Cerebral Cortex; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cysteine; Dose-Response Relationship, Drug; Electric Stimulation; Female; GTP-Binding Proteins; Male; Mice; Muscle Contraction; Naloxone; Narcotic Antagonists; Nociceptin; Opioid Peptides; Phenylalanine; Radioligand Assay; Rats; Rats, Wistar; Receptors, Opioid; Recombinant Proteins; Vas Deferens

2003
Opioid control of MAP kinase cascade.
    European journal of pharmacology, 2004, Oct-01, Volume: 500, Issue:1-3

    Topics: Cell Line; Dipeptides; Epidermal Growth Factor; ErbB Receptors; Etorphine; Humans; Ligands; MAP Kinase Signaling System; Morphine; Naloxone; Narcotics; Oligopeptides; Phenylalanine; Phosphorylation; Receptors, sigma; Thiophenes; Transfection

2004
Facilitation of enkephalins-induced delta-opioid behavioral responses by chronic amisulpride treatment.
    Neuroscience, 2005, Volume: 135, Issue:1

    Topics: Amisulpride; Animals; Behavior, Animal; Disulfides; Dopamine Antagonists; Enkephalins; Male; Mice; Motor Activity; Naloxone; Narcotic Antagonists; Pain Measurement; Phenylalanine; Reaction Time; Receptors, Opioid, delta; Sulpiride; Swimming

2005
Physiological control of emotion-related behaviors by endogenous enkephalins involves essentially the delta opioid receptors.
    Neuroscience, 2005, Volume: 135, Issue:2

    Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Disulfides; Dose-Response Relationship, Drug; Drug Interactions; Emotions; Enkephalins; Enzyme Inhibitors; Exploratory Behavior; Freezing Reaction, Cataleptic; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Phenylalanine; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, mu; Swimming; Time Factors

2005
Use of preproenkephalin knockout mice and selective inhibitors of enkephalinases to investigate the role of enkephalins in various behaviours.
    Psychopharmacology, 2008, Volume: 196, Issue:2

    Topics: Analysis of Variance; Animals; Behavior, Animal; CD13 Antigens; Disulfides; Dose-Response Relationship, Drug; Enkephalins; Enzyme Inhibitors; Injections, Intravenous; Mice; Mice, Inbred DBA; Mice, Knockout; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Neprilysin; Phenylalanine; Protein Precursors; Swimming

2008
TGF-β and opioid receptor signaling crosstalk results in improvement of endogenous and exogenous opioid analgesia under pathological pain conditions.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014, Apr-09, Volume: 34, Issue:15

    Topics: Adenylyl Cyclase Inhibitors; Analgesia; Analgesics, Opioid; Animals; Disulfides; Hyperalgesia; Infusions, Subcutaneous; Membrane Proteins; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Neuralgia; Peripheral Nerve Injuries; Phenylalanine; Receptors, Opioid, delta; Receptors, Opioid, mu; Sciatic Nerve; Signal Transduction; Spinal Cord; Transforming Growth Factor beta

2014