phenylalanine has been researched along with naloxone in 57 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (42.11) | 18.7374 |
| 1990's | 23 (40.35) | 18.2507 |
| 2000's | 8 (14.04) | 29.6817 |
| 2010's | 2 (3.51) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Bhargava, HN | 1 |
| Fournié-Zaluski, MC; Noble, F; Roques, BP; Turcaud, S | 1 |
| Coric, P; Fournié-Zaluski, MC; Noble, F; Roques, BP | 1 |
| Fournie-Zaluski, MC; Noble, F; Roques, BP; Soleilhac, JM; Soroca-Lucas, E; Turcaud, S | 1 |
| Fournié-Zaluski, MC; Maldonado, R; Roques, BP | 1 |
| Fournié-Zaluski, MC; Noble, F; Peyroux, J; Roques, BP; Schmidt, C | 1 |
| Panocka, I; Sadowski, B | 1 |
| Feger, J; Maldonado, R; Roques, BP; Waksman, G | 1 |
| Feger, J; Fournié-Zaluski, MC; Maldonado, R; Roques, BP | 1 |
| Dygai, AM; Goldberg, ED; Shakhov, VP; Zakharova, O | 1 |
| Carlson, HE | 1 |
| Callebert, J; Daugé, V; Feger, J; Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Villette, JM | 1 |
| Herblin, WF; Kauer, JC; Tam, SW | 1 |
| Lebedev, VP; Petriaevskaia, NV; Savchenko, AB | 1 |
| Takeshige, C | 1 |
| Hyodo, M; Ikeuchi, T; Kawachi, A; Kitade, T; Minamikawa, M; Morikawa, K; Odahara, Y; Sakai, T; Shinohara, S; Toyota, S | 1 |
| Ehrenpreis, S | 1 |
| Gianoulakis, C; Gupta, A | 1 |
| Kimura, H; Mapelli, C; Stammer, CH | 1 |
| Dong, WK; Halpern, LM | 1 |
| Cohen, S; Ouyang, A; Reynolds, JC | 1 |
| Sarne, Y; Segev, S; Urca, G | 1 |
| Albonetti, ME; D'Udine, B; Oliverio, A | 1 |
| Hosoya, E; Nozaki, M; Oka, T | 1 |
| Collier, HO; Francis, DL; Schneider, C | 1 |
| Ho, IK; Loh, HH; Lu, SE; Stolman, S; Way, EL | 1 |
| Duggan, AW; Foong, FW; Zhao, ZQ | 1 |
| Kubota, K; Natsuoka, Y; Sakuma, M; Uruno, T | 1 |
| Bodnar, RJ; Butler, PD | 1 |
| Stone, TW | 1 |
| Eshel, Y; Keren, O; Korczyn, AD | 1 |
| Cheng, RSS; Pomeranz, B | 1 |
| Barrett, GD; Mitchell, D; Woolf, CJ | 1 |
| Gibert-Rahola, J; Maldonado, R; Mico, JA; Roques, BP; Tejedor-Real, P | 1 |
| Kaliuzhnyĭ, LV; Kozlov, AIu; Litvinova, SV; Shul'govskiĭ, VV | 1 |
| Blommaert, A; Fournié-Zaluski, MC; Noble, F; Roques, BP | 1 |
| Blommaert, AG; Ducos, B; Fournie-Zaluski, MC; Maldonado, R; Roques, BP; Valverde, O | 1 |
| Fournié-Zaluski, MC; Noble, F; Roques, BP | 2 |
| Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Turcaud, S; Valverde, O | 1 |
| Noble, F; Roques, BP; Smadja, C | 1 |
| Coric, P; Fournié-Zaluski, MC; Noble, F; Roques, BP; Turcaud, S | 1 |
| Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Ruiz, F | 1 |
| Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Valverde, O | 1 |
| Fournié-Zaluski, MC; Fuentes, JA; Hernando, F; Roques, BP; Ruiz-Gayo, M | 1 |
| Carp, HM; Fournié-Zaluski, MC; Jayaram, A; Noreuil, T; Singh, P | 1 |
| Chover-Gonzalez, AJ; Fournié-Zaluski, MC; Gibert-Rahola, J; Lai-Kuen, R; Maldonado, R; Mico, JA; Ortega-Alvaro, A; Roques, BP | 1 |
| Boudinot, E; Denavit-Saubié, M; Fournié-Zaluski, M; Foutz, AS; Morin-Surun, M; Roques, BP | 1 |
| Boucher, M; Coudoré-Civiale, MA; Eschalier, A; Fournié-Zaluski, MC; Méen, M; Roques, BP | 1 |
| Besson, JM; Buritova, J; Fournié-Zaluski, MC; Le Guen, S; Roques, BP | 1 |
| Barnes, TA; Calo, G; Carra, G; Guerrini, R; Kitayama, M; Lambert, DG; McDonald, J; Rowbotham, DJ; Smith, G | 1 |
| Eisinger, DA; Schulz, R; Wehmeyer, A | 1 |
| Cordonnier, L; Noble, F; Roques, BP; Sanchez, M | 1 |
| Guen, SL; Kieffer, BL; Nieto, MM; Noble, F; Roques, BP | 1 |
| Benturquia, N; Bilkei-Gorzo, A; Noble, F; Roques, BP; Zimmer, A | 1 |
| Hurlé, MA; Lantero, A; Pílar-Cuellar, F; Roques, BP; Santillán, R; Tramullas, M; Valdizán, E | 1 |
1 review(s) available for phenylalanine and naloxone
| Article | Year |
|---|---|
[Enkephalinase mechanisms of tolerance of analgetic action of opioids. Effects of D-phenylalanine and naloxone].
Topics: Animals; Drug Resistance; Drug Tolerance; Mice; Morphine; Naloxone; Neprilysin; Opioid Peptides; Phenylalanine; Rabbits; Rats; Rats, Wistar | 1994 |
56 other study(ies) available for phenylalanine and naloxone
| Article | Year |
|---|---|
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Studies of the possible role of brain endorphins in pentobarbital anesthesia and toxicity in mice.
Topics: Animals; Brain; Endorphins; Enkephalins; Leucine; Male; Mice; Morphine; Naloxone; Naltrexone; Pentobarbital; Phenylalanine | 1979 |
Repeated systemic administration of the mixed inhibitor of enkephalin-degrading enzymes, RB101, does not induce either antinociceptive tolerance or cross-tolerance with morphine.
Topics: Analgesics; Animals; Disulfides; Dose-Response Relationship, Drug; Drug Tolerance; Indoles; Male; Mice; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Phenylalanine; Prodrugs; Reaction Time | 1992 |
Lack of physical dependence in mice after repeated systemic administration of the mixed inhibitor prodrug of enkephalin-degrading enzymes, RB101.
Topics: Animals; Behavior, Animal; Body Weight; Disulfides; Injections, Intraventricular; Male; Mice; Morphine; Naloxone; Phenylalanine; Prodrugs; Substance Withdrawal Syndrome; Substance-Related Disorders | 1992 |
Inhibition of the enkephalin-metabolizing enzymes by the first systemically active mixed inhibitor prodrug RB 101 induces potent analgesic responses in mice and rats.
Topics: Aminopeptidases; Analgesia; Analgesics; Animals; Cell Membrane; Chromatography, High Pressure Liquid; Disulfides; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Inhibitors; Injections, Intravenous; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Naloxone; Neprilysin; Phenylalanine; Prodrugs; Rats; Rats, Inbred Strains | 1992 |
Attenuation of the morphine withdrawal syndrome by inhibition of catabolism of endogenous enkephalins in the periaqueductal gray matter.
Topics: Analgesics; Animals; Behavior, Animal; Body Temperature; Body Weight; Corticosterone; Dipeptides; Enkephalins; Hydroxamic Acids; Male; Morphine; Morphine Dependence; Naloxone; Neprilysin; Periaqueductal Gray; Phenylalanine; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Thiorphan | 1992 |
Analgesic responses elicited by endogenous enkephalins (protected by mixed peptidase inhibitors) in a variety of morphine-sensitive noxious tests.
Topics: Analgesics; Animals; Dipeptides; Dose-Response Relationship, Drug; Enkephalins; Hydroxamic Acids; Male; Mice; Morphine; Naloxone; Phenylalanine; Rats; Rats, Inbred Strains | 1991 |
Potentiation of swim analgesia by D-amino acids in mice is genotype dependent.
Topics: Amino Acids; Analgesia; Animals; Female; Genotype; Leucine; Male; Mice; Mice, Inbred Strains; Naloxone; Pain Measurement; Phenylalanine; Reaction Time; Swimming | 1990 |
Naloxone-induced withdrawal syndrome after administration of selective opioid agonists or after activation of the endogenous enkephalinergic system.
Topics: Animals; Behavior, Animal; Body Temperature; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hydroxamic Acids; Naloxone; Narcotics; Oligopeptides; Phenylalanine; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Weight Loss | 1990 |
Differences in physical dependence induced by selective mu or delta opioid agonists and by endogenous enkephalins protected by peptidase inhibitors.
Topics: Animals; Cerebral Ventricles; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hydroxamic Acids; Injections, Intraventricular; Male; Naloxone; Neprilysin; Oligopeptides; Phenylalanine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Reference Values; Substance Withdrawal Syndrome; Substance-Related Disorders | 1990 |
The modulating influence of enkephalins on the bone marrow haemopoiesis in stress.
Topics: Animals; Bone Marrow; Cell Count; Cell Differentiation; Cell Division; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Hematopoiesis; Male; Mice; Naloxone; Phenylalanine; Restraint, Physical; Stress, Physiological; Time Factors | 1990 |
Prolactin stimulation by protein is mediated by amino acids in humans.
Topics: Adult; Dietary Proteins; Dose-Response Relationship, Drug; Female; Humans; Male; Naloxone; Phenylalanine; Prolactin; Sex Factors; Time Factors; Tyrosine; Vagotomy | 1989 |
Comparison of selective and complete inhibitors of enkephalin-degrading enzymes on morphine withdrawal syndrome.
Topics: Animals; Behavior, Animal; Body Temperature; Body Weight; Corticosterone; Dipeptides; Hydroxamic Acids; Injections, Intraventricular; Male; Morphine Dependence; Naloxone; Neprilysin; Phenylalanine; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Thiorphan | 1989 |
Photoinactivation of the mu opioid receptor using a novel synthetic morphiceptin analog.
Topics: Affinity Labels; Animals; Brain; Chemical Phenomena; Chemistry; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guinea Pigs; In Vitro Techniques; Light; Naloxone; Phenylalanine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1987 |
[The opiate mechanism of transcranial electroanalgesia in rats and mice].
Topics: Animals; Drug Tolerance; Electronarcosis; Endorphins; Leucine; Male; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Phenylalanine; Rats; Rats, Inbred Strains; Receptors, Opioid | 1988 |
Differentiation between acupuncture and non-acupuncture points by association with analgesia inhibitory system.
Topics: Acupuncture Therapy; Animals; Brain; Dexamethasone; Electric Stimulation; Evoked Potentials; Hypothalamus, Posterior; Morphine; Naloxone; Neural Inhibition; Nociceptors; Periaqueductal Gray; Phenylalanine; Pituitary Gland; Rabbits; Rats; Rats, Inbred Strains; Sensory Thresholds; Thalamic Nuclei | 1985 |
Studies on the enhanced effect of acupuncture analgesia and acupuncture anesthesia by D-phenylalanine (first report)--effect on pain threshold and inhibition by naloxone.
Topics: Acupuncture Therapy; Adult; Analgesia; Anesthesia; Double-Blind Method; Female; Humans; Male; Naloxone; Pain; Phenylalanine; Placebos; Receptors, Opioid; Sensory Thresholds | 1988 |
Analgesic properties of enkephalinase inhibitors: animal and human studies.
Topics: Acupuncture Therapy; Analgesia; Analgesics; Animals; Bacitracin; beta-Endorphin; Brain; Drug Synergism; Endorphins; Enkephalin, Methionine; Humans; Kinetics; Mice; Naloxone; Neprilysin; Pain, Intractable; Phenylalanine; Protease Inhibitors; Puromycin; Stereoisomerism | 1985 |
Neurointermediate lobe transplanted under the kidney capsule modifies the activity of the neurointermediate lobe in situ, but does not respond to opiate treatment.
Topics: Animals; beta-Endorphin; beta-Lipotropin; Endorphins; Histocytochemistry; Kidney; Kinetics; Male; Morphine; Naloxone; Phenylalanine; Pituitary Gland; Pro-Opiomelanocortin; Rats; Rats, Inbred Strains | 1986 |
Synthesis of four diastereomeric enkephalins incorporating cyclopropyl phenylalanine.
Topics: Animals; Binding, Competitive; Brain; Circular Dichroism; Cyclopropanes; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Indicators and Reagents; Male; Naloxone; Phenylalanine; Protein Conformation; Rats; Rats, Inbred Strains; Receptors, Opioid; Stereoisomerism; Structure-Activity Relationship | 1986 |
D-phenylalanine: a putative enkephalinase inhibitor studied in a primate acute pain model.
Topics: Animals; Aspirin; Avoidance Learning; Carboxypeptidases; Drug Interactions; Isomerism; Macaca fascicularis; Male; Morphine; Naloxone; Neprilysin; Pain; Phenylalanine; Protease Inhibitors; Sensory Thresholds; Tolmetin | 1986 |
Opiate nerves mediate feline pyloric response to intraduodenal amino acids.
Topics: Amino Acids; Animals; Cats; Duodenum; Endorphins; Gastrointestinal Motility; Naloxone; Neural Pathways; Phenylalanine; Pylorus; Sincalide; Stimulation, Chemical; Tryptophan | 1985 |
Footshock-induced analgesia: its opioid nature depends on the strain of rat.
Topics: Analgesia; Animals; Electroshock; Endorphins; Foot; Naloxone; Pain; Periaqueductal Gray; Phenylalanine; Rats; Rats, Inbred Strains; Rats, Inbred WKY; Species Specificity | 1985 |
D-Amino acids influence ultrasonic calling in mice pups: effects of D-phenylalanine and D-leucine.
Topics: Animals; Animals, Newborn; Anxiety, Separation; Drug Therapy, Combination; Endorphins; Humans; Leucine; Mice; Naloxone; Object Attachment; Phenylalanine; Ultrasonics; Vocalization, Animal | 1985 |
Effects of p-chlorophenylalanine and cholinergic antagonists on body temperature changes induced by the administration of morphine to nontolerant and morphine-tolerant rats.
Topics: Animals; Atropine; Body Temperature; Drug Tolerance; Fenclonine; Male; Methyltyrosines; Morphine; Naloxone; Phenylalanine; Rats; Rats, Inbred Strains; Scopolamine; Serotonin; Sympathomimetics; Time Factors | 1972 |
Modification of morphine withdrawal by drugs interacting with humoral mechanisms: some contradictions and their interpretation.
Topics: Animals; Atropine; Behavior, Animal; Drug Interactions; Fenclonine; Heroin; Humans; Indomethacin; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morphine; Motor Activity; Naloxone; Phenylalanine; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Time Factors | 1972 |
Influence of p-chlorophenylalanine on morphine tolerance and physical dependence and regional brain serotonin turnover studies in morphine tolerant-dependent mice.
Topics: Analgesia; Animals; Body Weight; Brain Chemistry; Brain Stem; Drug Tolerance; Fenclonine; Humans; Hypothalamus; Male; Mice; Mice, Inbred Strains; Morphine; Morphine Dependence; Naloxone; Pargyline; Phenylalanine; Rats; Rats, Inbred Strains; Serotonin; Substance Withdrawal Syndrome; Time Factors | 1972 |
Lack of interaction between methionine enkephalin and D-phenylalanine on nociceptive and non-nociceptive responses of dorsal horn neurones of the cat.
Topics: Analgesia; Animals; Cats; Drug Interactions; Enkephalin, Methionine; Naloxone; Neurons; Pain; Phenylalanine; Receptors, Opioid; Reflex; Spinal Cord | 1984 |
Characteristics of analgesia induced by noncatecholic phenylethylamine derivatives: possible involvement of endogenous opioid peptides and serotonin in phenylethylamine analog-induced analgesia.
Topics: 2-Hydroxyphenethylamine; Amphetamine; Analgesics; Animals; Drug Interactions; Endorphins; Fenclonine; Male; Methysergide; Mice; Naloxone; Pargyline; Phenethylamines; Phenylalanine; Reserpine; Serotonin | 1984 |
Modulation of deprivation-induced food intake by D-phenylalanine.
Topics: Animals; Dose-Response Relationship, Drug; Eating; Female; Food Deprivation; Hunger; Naloxone; Phenylalanine; Rats; Rats, Inbred Strains; Receptors, Opioid | 1983 |
A comparison of the effects of morphine, enkephalin, kyotorphin and D-phenylalanine on rat central neurones.
Topics: Animals; Brain; Cerebral Cortex; Endorphins; Enkephalin, Methionine; Globus Pallidus; Iontophoresis; Male; Morphine; Naloxone; Neurons; Phenylalanine; Rats | 1983 |
Enkephalin mydriasis in mice.
Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Mydriatics; Naloxone; Phenylalanine | 1980 |
A combined treatment with D-amino acids and electroacupuncture produces a greater analgesia than either treatment alone; naloxone reverses these effects.
Topics: Acupuncture Therapy; Analgesia; Animals; Electric Stimulation; Female; Leucine; Mice; Naloxone; Pain Management; Phenylalanine | 1980 |
Antinociceptive effect of peripheral segmental electrical stimulation in the rat.
Topics: Animals; Electric Stimulation; Male; Morphine; Naloxone; Nociceptors; Phenylalanine; Rats; Reaction Time; Serotonin; Thoracic Surgery | 1980 |
Implication of endogenous opioid system in the learned helplessness model of depression.
Topics: Animals; Antidepressive Agents, Tricyclic; Avoidance Learning; Depression; Electroshock; Endorphins; Enkephalins; Helplessness, Learned; Hydroxamic Acids; Imipramine; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Neprilysin; Phenylalanine; Protease Inhibitors; Rats; Rats, Wistar | 1995 |
A selective CCKB receptor antagonist potentiates, mu-, but not delta-opioid receptor-mediated antinociception in the formalin test.
Topics: Analgesics; Animals; Disulfides; Enkephalins; Formaldehyde; Indoles; Male; Meglumine; Mice; Morphine; Naloxone; Naltrexone; Pain Measurement; Phenylalanine; Receptors, Cholecystokinin; Receptors, Opioid, delta; Receptors, Opioid, mu | 1995 |
Inhibition of morphine withdrawal by the association of RB 101, an inhibitor of enkephalin catabolism, and the CCKB antagonist PD-134,308.
Topics: Analgesics; Animals; Behavior, Animal; Binding, Competitive; Body Temperature; Diprenorphine; Disulfides; Drug Combinations; Drug Synergism; Enkephalins; Indoles; Male; Meglumine; Mice; Morphine; Motor Activity; Naloxone; Phenylalanine; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Substance Withdrawal Syndrome; Weight Loss | 1995 |
Paradoxical analgesia induced by low doses of naloxone is not potentiated by complete inhibition of enkephalin degradation.
Topics: Abdominal Muscles; Aminopeptidases; Analgesics; Animals; CD13 Antigens; Disulfides; Enkephalins; Male; Mice; Naloxone; Neprilysin; Pain Measurement; Phenylalanine | 1994 |
Antinociceptive response induced by mixed inhibitors of enkephalin catabolism in peripheral inflammation.
Topics: Analgesics; Animals; Disulfides; Enkephalins; Hydroxamic Acids; Inflammation; Injections, Intraventricular; Male; Morphine; Naloxone; Narcotic Antagonists; Neprilysin; Pain; Pain Measurement; Phenylalanine; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley | 1994 |
Role of endogenous cholecystokinin in the facilitation of mu-mediated antinociception by delta-opioid agonists.
Topics: Amino Acid Sequence; Analgesia; Animals; Benzodiazepinones; Cholecystokinin; Devazepide; Disulfides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Molecular Sequence Data; Naloxone; Naltrexone; Oligopeptides; Peptide Fragments; Phenylalanine; Receptors, Opioid, delta; Receptors, Opioid, mu; Sincalide | 1994 |
Assessment of physical dependence after continuous perfusion into the rat jugular vein of the mixed inhibitor of enkephalin-degrading enzymes, RB 101.
Topics: Analgesics; Animals; Behavior, Animal; Catheterization, Central Venous; Disulfides; Enzyme Inhibitors; Injections, Subcutaneous; Male; Morphine Dependence; Naloxone; Phenylalanine; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Substance-Related Disorders | 1994 |
Unlike morphine the endogenous enkephalins protected by RB101 are unable to establish a conditioned place preference in mice.
Topics: Animals; Conditioning, Operant; Disulfides; Drug Interactions; Enkephalins; Enzyme Inhibitors; Male; Mice; Morphine; Naloxone; Phenylalanine; Prodrugs; Substance-Related Disorders | 1993 |
Similar decrease in spontaneous morphine abstinence by methadone and RB 101, an inhibitor of enkephalin catabolism.
Topics: Analgesics; Animals; Disulfides; Drug Combinations; Enkephalins; Indoles; Male; Meglumine; Methadone; Morphine; Naloxone; Phenylalanine; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Substance Withdrawal Syndrome | 1996 |
Similar involvement of several brain areas in the antinociception of endogenous and exogenous opioids.
Topics: Analgesia; Analgesics, Opioid; Animals; Brain; Disulfides; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; Opioid Peptides; Phenylalanine; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley | 1996 |
Antidepressant-like effects of CCK(B) receptor antagonists: involvement of the opioid system.
Topics: Animals; Antidepressive Agents; Benzodiazepinones; Devazepide; Disulfides; Endorphins; Male; Mice; Naloxone; Naltrexone; Phenylalanine; Phenylurea Compounds; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Sincalide | 1996 |
RB 101, a purported pro drug inhibitor of enkephalin metabolism, is antinociceptive in pregnant mice.
Topics: Analgesics; Analgesics, Opioid; Animals; Depression, Chemical; Disulfides; Enkephalins; Female; Mice; Morphine; Naloxone; Narcotic Antagonists; Pain Threshold; Phenylalanine; Pregnancy; Pregnancy, Animal; Prodrugs; Respiration | 1997 |
Antinociception produced by the peptidase inhibitor, RB 101, in rats with adrenal medullary transplant into the spinal cord.
Topics: Adrenal Medulla; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Disulfides; Injections, Intravenous; Male; Naloxone; Narcotic Antagonists; Pain; Phentolamine; Phenylalanine; Protease Inhibitors; Rats; Rats, Wistar; Spinal Cord; Subarachnoid Space; Transplantation, Autologous | 1998 |
Effects of the potent analgesic enkephalin-catabolizing enzyme inhibitors RB101 and kelatorphan on respiration.
Topics: Analgesics; Animals; Cats; Dipeptides; Disulfides; Enkephalins; Enzyme Inhibitors; Mice; Naloxone; Narcotic Antagonists; Phenylalanine; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Respiration | 2001 |
Enhancement of the effects of a complete inhibitor of enkephalin-catabolizing enzymes, RB 101, by a cholecystokinin-B receptor antagonist in diabetic rats.
Topics: Aminopeptidases; Animals; Diabetes Mellitus, Experimental; Disulfides; Drug Synergism; Indoles; Male; Meglumine; Naloxone; Naltrexone; Neprilysin; Pain; Pain Measurement; Phenylalanine; Pressure; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Time Factors; Vocalization, Animal; Weight Loss | 2001 |
Antinociceptive effects of RB101(S), a complete inhibitor of enkephalin-catabolizing enzymes, are enhanced by (+)-HA966, a functional NMDA receptor antagonist: a c-Fos study in the rat spinal cord.
Topics: Analgesics; Animals; Carrageenan; Disulfides; Drug Therapy, Combination; Enkephalins; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Immunohistochemistry; Inflammation; Male; Naloxone; Narcotic Antagonists; Pain; Phenylalanine; Proto-Oncogene Proteins c-fos; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 2003 |
Pharmacological profile of the cyclic nociceptin/orphanin FQ analogues c[Cys10,14]N/OFQ(1-14)NH2 and c[Nphe1,Cys10,14]N/OFQ(1-14)NH2.
Topics: Animals; Binding, Competitive; Cell Membrane; Cerebral Cortex; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cysteine; Dose-Response Relationship, Drug; Electric Stimulation; Female; GTP-Binding Proteins; Male; Mice; Muscle Contraction; Naloxone; Narcotic Antagonists; Nociceptin; Opioid Peptides; Phenylalanine; Radioligand Assay; Rats; Rats, Wistar; Receptors, Opioid; Recombinant Proteins; Vas Deferens | 2003 |
Opioid control of MAP kinase cascade.
Topics: Cell Line; Dipeptides; Epidermal Growth Factor; ErbB Receptors; Etorphine; Humans; Ligands; MAP Kinase Signaling System; Morphine; Naloxone; Narcotics; Oligopeptides; Phenylalanine; Phosphorylation; Receptors, sigma; Thiophenes; Transfection | 2004 |
Facilitation of enkephalins-induced delta-opioid behavioral responses by chronic amisulpride treatment.
Topics: Amisulpride; Animals; Behavior, Animal; Disulfides; Dopamine Antagonists; Enkephalins; Male; Mice; Motor Activity; Naloxone; Narcotic Antagonists; Pain Measurement; Phenylalanine; Reaction Time; Receptors, Opioid, delta; Sulpiride; Swimming | 2005 |
Physiological control of emotion-related behaviors by endogenous enkephalins involves essentially the delta opioid receptors.
Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Disulfides; Dose-Response Relationship, Drug; Drug Interactions; Emotions; Enkephalins; Enzyme Inhibitors; Exploratory Behavior; Freezing Reaction, Cataleptic; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Phenylalanine; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, mu; Swimming; Time Factors | 2005 |
Use of preproenkephalin knockout mice and selective inhibitors of enkephalinases to investigate the role of enkephalins in various behaviours.
Topics: Analysis of Variance; Animals; Behavior, Animal; CD13 Antigens; Disulfides; Dose-Response Relationship, Drug; Enkephalins; Enzyme Inhibitors; Injections, Intravenous; Mice; Mice, Inbred DBA; Mice, Knockout; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Neprilysin; Phenylalanine; Protein Precursors; Swimming | 2008 |
TGF-β and opioid receptor signaling crosstalk results in improvement of endogenous and exogenous opioid analgesia under pathological pain conditions.
Topics: Adenylyl Cyclase Inhibitors; Analgesia; Analgesics, Opioid; Animals; Disulfides; Hyperalgesia; Infusions, Subcutaneous; Membrane Proteins; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Neuralgia; Peripheral Nerve Injuries; Phenylalanine; Receptors, Opioid, delta; Receptors, Opioid, mu; Sciatic Nerve; Signal Transduction; Spinal Cord; Transforming Growth Factor beta | 2014 |