phenylalanine and morphine

phenylalanine has been researched along with morphine in 65 studies

Research

Studies (65)

TimeframeStudies, this research(%)All Research%
pre-199036 (55.38)18.7374
1990's20 (30.77)18.2507
2000's6 (9.23)29.6817
2010's3 (4.62)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bellman, K; Knegtel, RM; Settimo, L1
Bhargava, HN1
Nordal, A; Paulsen, BS; Wold, JK1
Fournié-Zaluski, MC; Noble, F; Roques, BP; Turcaud, S1
Coric, P; Fournié-Zaluski, MC; Noble, F; Roques, BP1
Fournié-Zaluski, MC; Maldonado, R; Roques, BP1
Dove, B; Göres, E; Morgenstern, E1
Becker, A; Grecksch, G; Matthies, H1
Fournié-Zaluski, MC; Noble, F; Peyroux, J; Roques, BP; Schmidt, C1
Hisamitsu, T; Hishida, F; Mera, H; Takeshige, C; Tanaka, M1
Delay-Goyet, P; Meucci, E; Roques, BP; Zajac, JM1
Lebedev, VP; Petriaevskaia, NV; Savchenko, AB1
Takeshige, C1
Gianoulakis, C; Gupta, A1
Dong, WK; Halpern, LM1
Doetsch, RN; Smith, JL1
Hayashi, G; Maruyama, Y; Smits, SE; Takemori, AE1
Hosoya, E; Nozaki, M; Oka, T1
Collier, HO; Francis, DL; Schneider, C1
Ho, IK; Loh, HH; Lu, SE; Stolman, S; Way, EL1
Norton, PR1
Fennessy, MR; Lee, JR1
Antopol, W; Datta, RK1
Mrochek, JE; Rainey, WT1
Eidelberg, E; Schwartz, AS2
Nozaki, M; Oka, T1
Major, CT; Pleuvry, BJ; Rees, JM1
Loh, HH; Shen, FH; Way, EL1
Grahame-Smith, DG; Marshall, I1
Blake, DE; Haubrich, DR1
Tenen, SS1
Loh, HH; Shen, F; Way, EL1
Ehrenpreis, S1
Stone, TW1
Bodnar, RJ; Lattner, M; Wallace, MM1
Castellano, C; Filibeck, U; Oliverio, A1
Haarmann, I; Höllt, V; Jerlicz, M; Przewlocki, R1
Eshel, Y; Keren, O; Korczyn, AD1
Barrett, GD; Mitchell, D; Woolf, CJ1
Alleva, E; Castellano, C; Oliverio, A1
Gibert-Rahola, J; Maldonado, R; Mico, JA; Roques, BP; Tejedor-Real, P1
Kaliuzhnyĭ, LV; Kozlov, AIu; Litvinova, SV; Shul'govskiĭ, VV1
Blommaert, A; Fournié-Zaluski, MC; Noble, F; Roques, BP1
Blommaert, AG; Ducos, B; Fournie-Zaluski, MC; Maldonado, R; Roques, BP; Valverde, O1
Grecksch, G; Rüthrich, HL; Schmidt, R1
Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Turcaud, S; Valverde, O1
Abbadie, C; Besson, JM; Fournié-Zaluski, MC; Honoré, P; Roques, BP1
Kaliuzhnyĭ, LV; Kozlov, AIu; Litvinova, SV1
Fournié-Zaluski, MC; Noble, F; Roques, BP1
Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Ruiz, F1
Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Valverde, O1
Carp, HM; Fournié-Zaluski, MC; Jayaram, A; Noreuil, T; Singh, P1
Borrelli, E; Maldonado, R; Roques, BP; Saiardi, A; Samad, TA; Valverde, O1
Beslot, F; Daugé, V; Fournié-Zaluski, MC; Noble, F; Roques, BP; Valverde, O1
Benavides, J; Fournié-Zaluski, MC; Nieto, MM; Noble, F; Roques, BP; Walker, J; Wilson, J1
Besson, JM; Buritova, J; Fournié-Zaluski, MC; Le Guen, S; Noble, F; Roques, BP1
CONTRERAS, E; CROXATTO, R; HUIDOBRO, F1
Eisinger, DA; Schulz, R; Wehmeyer, A1
Cordonnier, L; Noble, F; Roques, BP; Sanchez, M1
Benturquia, N; Bilkei-Gorzo, A; Noble, F; Roques, BP; Zimmer, A1
Hurlé, MA; Lantero, A; Pílar-Cuellar, F; Roques, BP; Santillán, R; Tramullas, M; Valdizán, E1
Akbarali, HI; Dewey, WL; Komla, E; Obeng, S; Selley, DE; Stevens, DL; Wang, H; Zhang, Y; Zheng, Y1
Doellgast, GJ; Meis, PJ1
Raine, DN1

Reviews

1 review(s) available for phenylalanine and morphine

ArticleYear
[Enkephalinase mechanisms of tolerance of analgetic action of opioids. Effects of D-phenylalanine and naloxone].
    Vestnik Rossiiskoi akademii meditsinskikh nauk, 1994, Issue:10

    Topics: Animals; Drug Resistance; Drug Tolerance; Mice; Morphine; Naloxone; Neprilysin; Opioid Peptides; Phenylalanine; Rabbits; Rats; Rats, Wistar

1994

Trials

1 trial(s) available for phenylalanine and morphine

ArticleYear
Studies on the relationship between 5-hydroxytryptamine turnover in brain and tolerance and physical dependence in mice.
    The Journal of pharmacology and experimental therapeutics, 1971, Volume: 178, Issue:1

    Topics: Animals; Aspirin; Brain; Cyclazocine; Drug Tolerance; Fenclonine; Humans; Levorphanol; Male; Methadone; Mice; Morphinans; Morphine; Morphine Dependence; Nalorphine; Pargyline; Pentazocine; Phenylalanine; Physostigmine; Placebos; Serotonin; Substance Withdrawal Syndrome

1971

Other Studies

63 other study(ies) available for phenylalanine and morphine

ArticleYear
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
Studies of the possible role of brain endorphins in pentobarbital anesthesia and toxicity in mice.
    Anesthesiology, 1979, Volume: 51, Issue:5

    Topics: Animals; Brain; Endorphins; Enkephalins; Leucine; Male; Mice; Morphine; Naloxone; Naltrexone; Pentobarbital; Phenylalanine

1979
Precursor incorporation experiments in Papaver alkaloid biosynthesis. II. Papaver somniferum L.
    Acta pharmaceutica Suecica, 1977, Volume: 14, Issue:4

    Topics: Codeine; Glycine; Morphine; Papaver; Phenylalanine; Plants, Medicinal; Thebaine; Urea

1977
Repeated systemic administration of the mixed inhibitor of enkephalin-degrading enzymes, RB101, does not induce either antinociceptive tolerance or cross-tolerance with morphine.
    European journal of pharmacology, 1992, Nov-13, Volume: 223, Issue:1

    Topics: Analgesics; Animals; Disulfides; Dose-Response Relationship, Drug; Drug Tolerance; Indoles; Male; Mice; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Phenylalanine; Prodrugs; Reaction Time

1992
Lack of physical dependence in mice after repeated systemic administration of the mixed inhibitor prodrug of enkephalin-degrading enzymes, RB101.
    European journal of pharmacology, 1992, Nov-13, Volume: 223, Issue:1

    Topics: Animals; Behavior, Animal; Body Weight; Disulfides; Injections, Intraventricular; Male; Mice; Morphine; Naloxone; Phenylalanine; Prodrugs; Substance Withdrawal Syndrome; Substance-Related Disorders

1992
Attenuation of the morphine withdrawal syndrome by inhibition of catabolism of endogenous enkephalins in the periaqueductal gray matter.
    Naunyn-Schmiedeberg's archives of pharmacology, 1992, Volume: 345, Issue:4

    Topics: Analgesics; Animals; Behavior, Animal; Body Temperature; Body Weight; Corticosterone; Dipeptides; Enkephalins; Hydroxamic Acids; Male; Morphine; Morphine Dependence; Naloxone; Neprilysin; Periaqueductal Gray; Phenylalanine; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Thiorphan

1992
[The analgesic action of d-phenylalanine in combination with morphine or methadone].
    Die Pharmazie, 1991, Volume: 46, Issue:12

    Topics: Action Potentials; Analgesics; Animals; Drug Interactions; Male; Methadone; Mice; Morphine; Pain Measurement; Phenylalanine; Rats; Rats, Inbred Strains

1991
Modulation of the antinociceptive effect of morphine by casomorphin derivatives.
    Biomedica biochimica acta, 1991, Volume: 50, Issue:12

    Topics: Amino Acid Sequence; Animals; Drug Interactions; Endorphins; Enkephalin, Leucine-2-Alanine; Male; Mice; Mice, Inbred ICR; Molecular Sequence Data; Morphine; Pain; Phenylalanine; Proline; Stereoisomerism; Structure-Activity Relationship

1991
Analgesic responses elicited by endogenous enkephalins (protected by mixed peptidase inhibitors) in a variety of morphine-sensitive noxious tests.
    European journal of pharmacology, 1991, Jan-10, Volume: 192, Issue:2

    Topics: Analgesics; Animals; Dipeptides; Dose-Response Relationship, Drug; Enkephalins; Hydroxamic Acids; Male; Mice; Morphine; Naloxone; Phenylalanine; Rats; Rats, Inbred Strains

1991
Inhibition of the analgesia inhibitory system by D-phenylalanine and proglumide.
    Brain research bulletin, 1991, Volume: 26, Issue:3

    Topics: Acupuncture Analgesia; Analgesia; Animals; Dexamethasone; Drug Tolerance; Male; Morphine; Periaqueductal Gray; Phenylalanine; Proglumide; Rats; Rats, Inbred Strains; Reaction Time

1991
Binding in vivo of selective mu and delta opioid receptor agonists: opioid receptor occupancy by endogenous enkephalins.
    European journal of pharmacology, 1989, Nov-21, Volume: 171, Issue:2-3

    Topics: Animals; Brain; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hydroxamic Acids; In Vitro Techniques; Injections; Kinetics; Male; Mice; Morphine; Oligopeptides; Phenylalanine; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Thiorphan

1989
[The opiate mechanism of transcranial electroanalgesia in rats and mice].
    Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova, 1988, Volume: 74, Issue:9

    Topics: Animals; Drug Tolerance; Electronarcosis; Endorphins; Leucine; Male; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Phenylalanine; Rats; Rats, Inbred Strains; Receptors, Opioid

1988
Differentiation between acupuncture and non-acupuncture points by association with analgesia inhibitory system.
    Acupuncture & electro-therapeutics research, 1985, Volume: 10, Issue:3

    Topics: Acupuncture Therapy; Animals; Brain; Dexamethasone; Electric Stimulation; Evoked Potentials; Hypothalamus, Posterior; Morphine; Naloxone; Neural Inhibition; Nociceptors; Periaqueductal Gray; Phenylalanine; Pituitary Gland; Rabbits; Rats; Rats, Inbred Strains; Sensory Thresholds; Thalamic Nuclei

1985
Neurointermediate lobe transplanted under the kidney capsule modifies the activity of the neurointermediate lobe in situ, but does not respond to opiate treatment.
    Canadian journal of physiology and pharmacology, 1986, Volume: 64, Issue:4

    Topics: Animals; beta-Endorphin; beta-Lipotropin; Endorphins; Histocytochemistry; Kidney; Kinetics; Male; Morphine; Naloxone; Phenylalanine; Pituitary Gland; Pro-Opiomelanocortin; Rats; Rats, Inbred Strains

1986
D-phenylalanine: a putative enkephalinase inhibitor studied in a primate acute pain model.
    Pain, 1986, Volume: 24, Issue:2

    Topics: Animals; Aspirin; Avoidance Learning; Carboxypeptidases; Drug Interactions; Isomerism; Macaca fascicularis; Male; Morphine; Naloxone; Neprilysin; Pain; Phenylalanine; Protease Inhibitors; Sensory Thresholds; Tolmetin

1986
Motility in Pseudomonas fluorescens with special reference to survival advantage and negative chemotaxis.
    Life sciences, 1968, Aug-15, Volume: 7, Issue:16

    Topics: Acetylcholine; Amobarbital; Chemotaxis; Chloramphenicol; Cocaine; Culture Media; Dicumarol; Dimethyl Sulfoxide; Flagella; Indoleacetic Acids; Locomotion; Microscopy, Phase-Contrast; Morphine; Phenols; Phenylalanine; Physostigmine; Pseudomonas; Pyridinium Compounds; Quinacrine; Strychnine; Surface-Active Agents; Urea

1968
Effects of p-chlorophenylalanine and cholinergic antagonists on body temperature changes induced by the administration of morphine to nontolerant and morphine-tolerant rats.
    The Journal of pharmacology and experimental therapeutics, 1972, Volume: 180, Issue:1

    Topics: Animals; Atropine; Body Temperature; Drug Tolerance; Fenclonine; Male; Methyltyrosines; Morphine; Naloxone; Phenylalanine; Rats; Rats, Inbred Strains; Scopolamine; Serotonin; Sympathomimetics; Time Factors

1972
Modification of morphine withdrawal by drugs interacting with humoral mechanisms: some contradictions and their interpretation.
    Nature, 1972, May-26, Volume: 237, Issue:5352

    Topics: Animals; Atropine; Behavior, Animal; Drug Interactions; Fenclonine; Heroin; Humans; Indomethacin; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morphine; Motor Activity; Naloxone; Phenylalanine; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Time Factors

1972
Influence of p-chlorophenylalanine on morphine tolerance and physical dependence and regional brain serotonin turnover studies in morphine tolerant-dependent mice.
    The Journal of pharmacology and experimental therapeutics, 1972, Volume: 182, Issue:1

    Topics: Analgesia; Animals; Body Weight; Brain Chemistry; Brain Stem; Drug Tolerance; Fenclonine; Humans; Hypothalamus; Male; Mice; Mice, Inbred Strains; Morphine; Morphine Dependence; Naloxone; Pargyline; Phenylalanine; Rats; Rats, Inbred Strains; Serotonin; Substance Withdrawal Syndrome; Time Factors

1972
The effects of drugs on barbiturate withdrawal convulsions in the rat.
    The Journal of pharmacy and pharmacology, 1970, Volume: 22, Issue:10

    Topics: Animals; Barbiturates; Chlordiazepoxide; Chlorpromazine; Ethanol; Ethosuximide; Female; Humans; Hydrazines; Hypnotics and Sedatives; Meprobamate; Methyltyrosines; Monoamine Oxidase Inhibitors; Morphine; Phenylalanine; Primidone; Rats; Reserpine; Seizures; Serotonin; Substance Withdrawal Syndrome; Tryptophan

1970
Modification of morphine analgesia by drugs affecting adrenergic and tryptaminergic mechanisms.
    The Journal of pharmacy and pharmacology, 1970, Volume: 22, Issue:12

    Topics: Analgesia; Animals; Female; Hot Temperature; Male; Methyltyrosines; Methysergide; Mice; Morphine; Phentolamine; Phenylalanine; Propranolol; Reserpine; Serotonin; Spasm

1970
Effect of chronic administration of morphine on mouse brain aminoacyl-tRNA synthetase and tRNA-amino acid binding.
    Brain research, 1973, Apr-27, Volume: 53, Issue:2

    Topics: Acetylation; Amino Acids; Amino Acyl-tRNA Synthetases; Animals; Arginine; Brain; Carbon Isotopes; Escherichia coli; Leucine; Male; Mice; Mice, Inbred C57BL; Morphine; Phenylalanine; RNA, Transfer

1973
Gas chromatography and mass spectrometry of some trimethylsilyl derivatives of urinary glucuronides.
    Analytical biochemistry, 1974, Volume: 57, Issue:1

    Topics: Aniline Compounds; Chromatography, Gas; Evaluation Studies as Topic; Glucuronates; Humans; Indoles; Mass Spectrometry; Methane; Methods; Morphine; Phenylacetates; Phenylalanine; Silicon; Structure-Activity Relationship; Toluene

1974
Possible mechanism of action of morphine on brain.
    Nature, 1970, Mar-21, Volume: 225, Issue:5238

    Topics: 5-Hydroxytryptophan; Animals; Brain; Depression, Chemical; Drug Tolerance; Iproniazid; Methyltyrosines; Morphine; Motor Activity; Norepinephrine; Phenylalanine; Rats; Serotonin

1970
The effects of parachlorophenylalanine on nontolerant rats and of cholinergic blocking drugs on toleaant rats to morphine.
    Japanese journal of pharmacology, 1970, Volume: 20, Issue:3

    Topics: Animals; Atropine; Behavior, Animal; Body Temperature; Drug Tolerance; Morphine; Movement; Parasympatholytics; Phenylalanine; Rats; Scopolamine

1970
Role of biogenic amines in morphine dependence in the rat.
    Life sciences. Pt. 1: Physiology and pharmacology, 1970, Jun-01, Volume: 9, Issue:11

    Topics: Animals; Brain; Dihydroxyphenylalanine; Dopamine; Female; Humans; Imipramine; Male; Methyltyrosines; Morphine; Nalorphine; Norepinephrine; Phenylalanine; Rats; Serotonin; Substance-Related Disorders; Thiocarbamates

1970
A comparison of the analgesia produced by morphine and the sympathomimetic drugs.
    British journal of pharmacology, 1970, Volume: 40, Issue:1

    Topics: Amphetamine; Analgesia; Animals; Iproniazid; Mice; Morphine; Phenylalanine; Reaction Time; Reserpine; Serotonin; Sympathomimetics; Tyrosine

1970
Brain serotonin turnover in morphine tolerant and dependent mice.
    The Journal of pharmacology and experimental therapeutics, 1970, Volume: 175, Issue:2

    Topics: Animals; Brain; Brain Chemistry; Chlorine; Drug Tolerance; Humans; Hydroxyindoleacetic Acid; Male; Mice; Morphinans; Morphine; Morphine Dependence; Narcotic Antagonists; Pargyline; Phenylalanine; Placebos; Serotonin; Sodium Chloride; Substance Withdrawal Syndrome

1970
Unchanged rate of brain serotonin synthesis during chronic morphine treatment and failure of parachlorophenylalanine to attenuate withdrawal syndrome in mice.
    Nature, 1970, Dec-19, Volume: 228, Issue:5277

    Topics: Animals; Brain; Female; Humans; Mice; Morphinans; Morphine; Motor Activity; Narcotic Antagonists; Phenylalanine; Serotonin; Substance Withdrawal Syndrome

1970
Modification of the hypothermic action of morphine after depletion of brain serotonin and catecholamines.
    Life sciences. Pt. 1: Physiology and pharmacology, 1971, Feb-01, Volume: 10, Issue:3

    Topics: Analysis of Variance; Animals; Body Temperature; Brain Chemistry; Catecholamines; Hypothermia; Male; Methyltyrosines; Morphine; Phenylalanine; Rats; Serotonin

1971
Antagonism of the analgesic effect of morphine and other drugs by p-chlorophenylalanine, a serotonin depletor.
    Psychopharmacologia, 1968, Volume: 12, Issue:4

    Topics: Analgesia; Animals; Brain; Codeine; Dextropropoxyphene; Electroshock; Male; Methadone; Morphine; Pain; Phenylalanine; Rats; Serotonin; Serotonin Antagonists

1968
Morphine tolerance, physical dependence, and synthesis of brain 5-hydroxytryptamine.
    Science (New York, N.Y.), 1968, Dec-13, Volume: 162, Issue:3859

    Topics: Animals; Antimetabolites; Brain; Cycloheximide; Depression, Chemical; Drug Tolerance; Humans; Mice; Morphine; Morphine Dependence; Movement Disorders; Narcotic Antagonists; Pargyline; Phenylalanine; Serotonin; Substance Withdrawal Syndrome

1968
D-phenylalanine and other enkephalinase inhibitors as pharmacological agents: implications for some important therapeutic application.
    Substance and alcohol actions/misuse, 1982, Volume: 3, Issue:4

    Topics: Acupuncture Therapy; Animals; Drug Tolerance; Enkephalin, Methionine; Enkephalins; Humans; Morphine; Morphine Dependence; Neprilysin; Nociceptors; Pain; Phenylalanine; Protease Inhibitors; Receptors, Opioid

1982
A comparison of the effects of morphine, enkephalin, kyotorphin and D-phenylalanine on rat central neurones.
    British journal of pharmacology, 1983, Volume: 79, Issue:1

    Topics: Animals; Brain; Cerebral Cortex; Endorphins; Enkephalin, Methionine; Globus Pallidus; Iontophoresis; Male; Morphine; Naloxone; Neurons; Phenylalanine; Rats

1983
Antagonism of stress-induced analgesia by D-phenylalanine, an anti-enkephalinase.
    Pharmacology, biochemistry, and behavior, 1980, Volume: 13, Issue:6

    Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Male; Morphine; Phenylalanine; Physical Exertion; Rats

1980
Cross-tolerance between D-amino acids and morphine in mice.
    Brain research, 1981, May-11, Volume: 212, Issue:1

    Topics: Animals; Drug Tolerance; Leucine; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Morphine; Motor Activity; Nociceptors; Phenylalanine; Stereoisomerism

1981
Long-term treatment of rats with morphine decreases in vitro biosynthesis in and release of beta-endorphin from intermediate/posterior lobes of pituitary.
    Advances in biochemical psychopharmacology, 1980, Volume: 22

    Topics: Animals; Endorphins; Haloperidol; Male; Molecular Weight; Morphine; Phenylalanine; Pituitary Gland; Pituitary Gland, Posterior; Rats; Time Factors

1980
Enkephalin mydriasis in mice.
    European journal of pharmacology, 1980, Jul-25, Volume: 65, Issue:2-3

    Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Mydriatics; Naloxone; Phenylalanine

1980
Antinociceptive effect of peripheral segmental electrical stimulation in the rat.
    Pain, 1980, Volume: 8, Issue:2

    Topics: Animals; Electric Stimulation; Male; Morphine; Naloxone; Nociceptors; Phenylalanine; Rats; Reaction Time; Serotonin; Thoracic Surgery

1980
Effect of L- and D-amino acids on analgesia and locomotor activity of mice: their interaction with morphine.
    Brain research, 1980, Sep-29, Volume: 198, Issue:1

    Topics: Amino Acids; Animals; Dose-Response Relationship, Drug; Leucine; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Morphine; Motor Activity; Nociceptors; Phenylalanine; Stereoisomerism

1980
Implication of endogenous opioid system in the learned helplessness model of depression.
    Pharmacology, biochemistry, and behavior, 1995, Volume: 52, Issue:1

    Topics: Animals; Antidepressive Agents, Tricyclic; Avoidance Learning; Depression; Electroshock; Endorphins; Enkephalins; Helplessness, Learned; Hydroxamic Acids; Imipramine; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Neprilysin; Phenylalanine; Protease Inhibitors; Rats; Rats, Wistar

1995
A selective CCKB receptor antagonist potentiates, mu-, but not delta-opioid receptor-mediated antinociception in the formalin test.
    European journal of pharmacology, 1995, Jan-24, Volume: 273, Issue:1-2

    Topics: Analgesics; Animals; Disulfides; Enkephalins; Formaldehyde; Indoles; Male; Meglumine; Mice; Morphine; Naloxone; Naltrexone; Pain Measurement; Phenylalanine; Receptors, Cholecystokinin; Receptors, Opioid, delta; Receptors, Opioid, mu

1995
Inhibition of morphine withdrawal by the association of RB 101, an inhibitor of enkephalin catabolism, and the CCKB antagonist PD-134,308.
    British journal of pharmacology, 1995, Volume: 114, Issue:5

    Topics: Analgesics; Animals; Behavior, Animal; Binding, Competitive; Body Temperature; Diprenorphine; Disulfides; Drug Combinations; Drug Synergism; Enkephalins; Indoles; Male; Meglumine; Mice; Morphine; Motor Activity; Naloxone; Phenylalanine; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Substance Withdrawal Syndrome; Weight Loss

1995
Phe1-substituted beta-casomorphin-5 analogues with analgesic activity.
    Peptides, 1994, Volume: 15, Issue:3

    Topics: Amino Acid Sequence; Analgesics; Animals; Disease Models, Animal; Drug Tolerance; Endorphins; Male; Molecular Sequence Data; Morphine; Pain; Peptide Fragments; Phenylalanine; Rats; Rats, Wistar; Vocalization, Animal

1994
Antinociceptive response induced by mixed inhibitors of enkephalin catabolism in peripheral inflammation.
    Pain, 1994, Volume: 58, Issue:1

    Topics: Analgesics; Animals; Disulfides; Enkephalins; Hydroxamic Acids; Inflammation; Injections, Intraventricular; Male; Morphine; Naloxone; Narcotic Antagonists; Neprilysin; Pain; Pain Measurement; Phenylalanine; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley

1994
Effects of opioids and non-opioids on c-Fos-like immunoreactivity induced in rat lumbar spinal cord neurons by noxious heat stimulation.
    European journal of pharmacology, 1994, Jun-13, Volume: 258, Issue:3

    Topics: Analgesia; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disulfides; Drug Interactions; Drug Tolerance; Hot Temperature; Immunohistochemistry; Injections, Intravenous; Male; Morphine; Neurons; Phenylalanine; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Cord

1994
[The enkephalinase mechanisms of the resistance and tolerance to the analgesic effect of morphine in rats. Differences in the effects of the action of D-phenylalanine in morphine-sensitive, morphine-tolerant and morphine-resistant rats].
    Biulleten' eksperimental'noi biologii i meditsiny, 1993, Volume: 116, Issue:7

    Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Drug Resistance; Drug Tolerance; Male; Morphine; Neprilysin; Pain; Phenylalanine; Rats; Rats, Wistar; Time Factors

1993
Unlike morphine the endogenous enkephalins protected by RB101 are unable to establish a conditioned place preference in mice.
    European journal of pharmacology, 1993, Jan-12, Volume: 230, Issue:2

    Topics: Animals; Conditioning, Operant; Disulfides; Drug Interactions; Enkephalins; Enzyme Inhibitors; Male; Mice; Morphine; Naloxone; Phenylalanine; Prodrugs; Substance-Related Disorders

1993
Similar decrease in spontaneous morphine abstinence by methadone and RB 101, an inhibitor of enkephalin catabolism.
    British journal of pharmacology, 1996, Volume: 119, Issue:1

    Topics: Analgesics; Animals; Disulfides; Drug Combinations; Enkephalins; Indoles; Male; Meglumine; Methadone; Morphine; Naloxone; Phenylalanine; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Substance Withdrawal Syndrome

1996
Similar involvement of several brain areas in the antinociception of endogenous and exogenous opioids.
    European journal of pharmacology, 1996, Sep-19, Volume: 312, Issue:1

    Topics: Analgesia; Analgesics, Opioid; Animals; Brain; Disulfides; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; Opioid Peptides; Phenylalanine; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley

1996
RB 101, a purported pro drug inhibitor of enkephalin metabolism, is antinociceptive in pregnant mice.
    Anesthesia and analgesia, 1997, Volume: 84, Issue:2

    Topics: Analgesics; Analgesics, Opioid; Animals; Depression, Chemical; Disulfides; Enkephalins; Female; Mice; Morphine; Naloxone; Narcotic Antagonists; Pain Threshold; Phenylalanine; Pregnancy; Pregnancy, Animal; Prodrugs; Respiration

1997
Absence of opiate rewarding effects in mice lacking dopamine D2 receptors.
    Nature, 1997, Aug-07, Volume: 388, Issue:6642

    Topics: Animals; Behavior, Addictive; Blotting, Northern; Disulfides; Enzyme Inhibitors; Locomotion; Mice; Morphine; Phenylalanine; Receptors, Dopamine D2; Reward; Substance-Related Disorders

1997
Delta9-tetrahydrocannabinol releases and facilitates the effects of endogenous enkephalins: reduction in morphine withdrawal syndrome without change in rewarding effect.
    The European journal of neuroscience, 2001, Volume: 13, Issue:9

    Topics: Analgesics; Animals; Binding, Competitive; Conditioning, Psychological; Diprenorphine; Disulfides; Dronabinol; Drug Interactions; Enkephalin, Methionine; Extracellular Space; Male; Mice; Morphine; Motor Activity; Narcotic Antagonists; Narcotics; Neurons; Nociceptors; Nucleus Accumbens; Phenylalanine; Psychotropic Drugs; Reward; Substance Withdrawal Syndrome; Tritium

2001
Facilitation of enkephalins catabolism inhibitor-induced antinociception by drugs classically used in pain management.
    Neuropharmacology, 2001, Volume: 41, Issue:4

    Topics: Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Disulfides; Enkephalins; Enzyme Inhibitors; Formaldehyde; Injections, Intravenous; Injections, Subcutaneous; Male; Mice; Morphine; Neprilysin; Pain; Pain Measurement; Phenylalanine; Pressure; Rats; Rats, Sprague-Dawley; Reaction Time

2001
RB101(S), a dual inhibitor of enkephalinases does not induce antinociceptive tolerance, or cross-tolerance with morphine: a c-Fos study at the spinal level.
    European journal of pharmacology, 2002, Apr-26, Volume: 441, Issue:3

    Topics: Analgesics; Animals; Disulfides; Drug Tolerance; Enkephalins; Enzyme Inhibitors; Male; Morphine; Phenylalanine; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Cord

2002
STUDIES ON MORPHINE. III. ACTION OF METABOLIC PRECURSORS TO SEROTONIN AND NORADRENALINE AND RELATED SUBSTANCES ON THE "ABSTINENCE SYNDROME" TO MORPHINE ON WHITE MICE.
    Archives internationales de pharmacodynamie et de therapie, 1963, Dec-01, Volume: 146

    Topics: Brain; Catecholamines; Dihydroxyphenylalanine; Ergot Alkaloids; Iproniazid; Kynurenine; Lysergic Acid Diethylamide; Methyldopa; Mice; Morphine; Nalorphine; Norepinephrine; ortho-Aminobenzoates; Pharmacology; Phenylalanine; Research; Serotonin; Shikimic Acid; Toxicology; Tryptophan; Tyrosine

1963
Opioid control of MAP kinase cascade.
    European journal of pharmacology, 2004, Oct-01, Volume: 500, Issue:1-3

    Topics: Cell Line; Dipeptides; Epidermal Growth Factor; ErbB Receptors; Etorphine; Humans; Ligands; MAP Kinase Signaling System; Morphine; Naloxone; Narcotics; Oligopeptides; Phenylalanine; Phosphorylation; Receptors, sigma; Thiophenes; Transfection

2004
Blockade of morphine-induced behavioral sensitization by a combination of amisulpride and RB101, comparison with classical opioid maintenance treatments.
    British journal of pharmacology, 2007, Volume: 151, Issue:1

    Topics: Amisulpride; Animals; Behavior, Animal; Buprenorphine; Disulfides; Male; Methadone; Mice; Morphine; Motor Activity; Opioid-Related Disorders; Phenylalanine; Sulpiride

2007
Use of preproenkephalin knockout mice and selective inhibitors of enkephalinases to investigate the role of enkephalins in various behaviours.
    Psychopharmacology, 2008, Volume: 196, Issue:2

    Topics: Analysis of Variance; Animals; Behavior, Animal; CD13 Antigens; Disulfides; Dose-Response Relationship, Drug; Enkephalins; Enzyme Inhibitors; Injections, Intravenous; Mice; Mice, Inbred DBA; Mice, Knockout; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Neprilysin; Phenylalanine; Protein Precursors; Swimming

2008
TGF-β and opioid receptor signaling crosstalk results in improvement of endogenous and exogenous opioid analgesia under pathological pain conditions.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014, Apr-09, Volume: 34, Issue:15

    Topics: Adenylyl Cyclase Inhibitors; Analgesia; Analgesics, Opioid; Animals; Disulfides; Hyperalgesia; Infusions, Subcutaneous; Membrane Proteins; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Neuralgia; Peripheral Nerve Injuries; Phenylalanine; Receptors, Opioid, delta; Receptors, Opioid, mu; Sciatic Nerve; Signal Transduction; Spinal Cord; Transforming Growth Factor beta

2014
Methylation Products of 6β- N-Heterocyclic Substituted Naltrexamine Derivatives as Potential Peripheral Opioid Receptor Modulators.
    ACS chemical neuroscience, 2018, 12-19, Volume: 9, Issue:12

    Topics: Analgesics, Opioid; Animals; CHO Cells; Constipation; Cricetulus; Diarrhea; Drug Partial Agonism; Gastrointestinal Agents; Gastrointestinal Transit; Imidazoles; Methylation; Mice; Molecular Docking Simulation; Morphine; Naltrexone; Narcotic Antagonists; Nociception; Phenylalanine; Quaternary Ammonium Compounds; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu

2018
Use of specific inhibitors to disciminate alkaline phosphatase isoenzymes originating from human liver, placenta and intestine: absence of meconial alkaline phosphatase in maternal serum.
    Clinical chemistry, 1979, Volume: 25, Issue:7

    Topics: Alkaline Phosphatase; Amniotic Fluid; Female; Humans; Intestines; Isoenzymes; Liver; Maternal-Fetal Exchange; Meconium; Phenylalanine; Placenta; Pregnancy; Tetramisole

1979
Inherited metabolic disease.
    Lancet (London, England), 1974, Oct-26, Volume: 2, Issue:7887

    Topics: Albumins; Amino Acid Metabolism, Inborn Errors; Chromatography; Clinical Laboratory Techniques; Costs and Cost Analysis; Cystic Fibrosis; Evaluation Studies as Topic; Galactosemias; Genetic Counseling; Humans; Hyperlipidemias; Infant; Infant, Newborn; Iron; Mass Screening; Meconium; Metabolism, Inborn Errors; Phenylalanine; Phenylketonurias

1974