phenylalanine has been researched along with morphine in 65 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 36 (55.38) | 18.7374 |
| 1990's | 20 (30.77) | 18.2507 |
| 2000's | 6 (9.23) | 29.6817 |
| 2010's | 3 (4.62) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Bhargava, HN | 1 |
| Nordal, A; Paulsen, BS; Wold, JK | 1 |
| Fournié-Zaluski, MC; Noble, F; Roques, BP; Turcaud, S | 1 |
| Coric, P; Fournié-Zaluski, MC; Noble, F; Roques, BP | 1 |
| Fournié-Zaluski, MC; Maldonado, R; Roques, BP | 1 |
| Dove, B; Göres, E; Morgenstern, E | 1 |
| Becker, A; Grecksch, G; Matthies, H | 1 |
| Fournié-Zaluski, MC; Noble, F; Peyroux, J; Roques, BP; Schmidt, C | 1 |
| Hisamitsu, T; Hishida, F; Mera, H; Takeshige, C; Tanaka, M | 1 |
| Delay-Goyet, P; Meucci, E; Roques, BP; Zajac, JM | 1 |
| Lebedev, VP; Petriaevskaia, NV; Savchenko, AB | 1 |
| Takeshige, C | 1 |
| Gianoulakis, C; Gupta, A | 1 |
| Dong, WK; Halpern, LM | 1 |
| Doetsch, RN; Smith, JL | 1 |
| Hayashi, G; Maruyama, Y; Smits, SE; Takemori, AE | 1 |
| Hosoya, E; Nozaki, M; Oka, T | 1 |
| Collier, HO; Francis, DL; Schneider, C | 1 |
| Ho, IK; Loh, HH; Lu, SE; Stolman, S; Way, EL | 1 |
| Norton, PR | 1 |
| Fennessy, MR; Lee, JR | 1 |
| Antopol, W; Datta, RK | 1 |
| Mrochek, JE; Rainey, WT | 1 |
| Eidelberg, E; Schwartz, AS | 2 |
| Nozaki, M; Oka, T | 1 |
| Major, CT; Pleuvry, BJ; Rees, JM | 1 |
| Loh, HH; Shen, FH; Way, EL | 1 |
| Grahame-Smith, DG; Marshall, I | 1 |
| Blake, DE; Haubrich, DR | 1 |
| Tenen, SS | 1 |
| Loh, HH; Shen, F; Way, EL | 1 |
| Ehrenpreis, S | 1 |
| Stone, TW | 1 |
| Bodnar, RJ; Lattner, M; Wallace, MM | 1 |
| Castellano, C; Filibeck, U; Oliverio, A | 1 |
| Haarmann, I; Höllt, V; Jerlicz, M; Przewlocki, R | 1 |
| Eshel, Y; Keren, O; Korczyn, AD | 1 |
| Barrett, GD; Mitchell, D; Woolf, CJ | 1 |
| Alleva, E; Castellano, C; Oliverio, A | 1 |
| Gibert-Rahola, J; Maldonado, R; Mico, JA; Roques, BP; Tejedor-Real, P | 1 |
| Kaliuzhnyĭ, LV; Kozlov, AIu; Litvinova, SV; Shul'govskiĭ, VV | 1 |
| Blommaert, A; Fournié-Zaluski, MC; Noble, F; Roques, BP | 1 |
| Blommaert, AG; Ducos, B; Fournie-Zaluski, MC; Maldonado, R; Roques, BP; Valverde, O | 1 |
| Grecksch, G; Rüthrich, HL; Schmidt, R | 1 |
| Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Turcaud, S; Valverde, O | 1 |
| Abbadie, C; Besson, JM; Fournié-Zaluski, MC; Honoré, P; Roques, BP | 1 |
| Kaliuzhnyĭ, LV; Kozlov, AIu; Litvinova, SV | 1 |
| Fournié-Zaluski, MC; Noble, F; Roques, BP | 1 |
| Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Ruiz, F | 1 |
| Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Valverde, O | 1 |
| Carp, HM; Fournié-Zaluski, MC; Jayaram, A; Noreuil, T; Singh, P | 1 |
| Borrelli, E; Maldonado, R; Roques, BP; Saiardi, A; Samad, TA; Valverde, O | 1 |
| Beslot, F; Daugé, V; Fournié-Zaluski, MC; Noble, F; Roques, BP; Valverde, O | 1 |
| Benavides, J; Fournié-Zaluski, MC; Nieto, MM; Noble, F; Roques, BP; Walker, J; Wilson, J | 1 |
| Besson, JM; Buritova, J; Fournié-Zaluski, MC; Le Guen, S; Noble, F; Roques, BP | 1 |
| CONTRERAS, E; CROXATTO, R; HUIDOBRO, F | 1 |
| Eisinger, DA; Schulz, R; Wehmeyer, A | 1 |
| Cordonnier, L; Noble, F; Roques, BP; Sanchez, M | 1 |
| Benturquia, N; Bilkei-Gorzo, A; Noble, F; Roques, BP; Zimmer, A | 1 |
| Hurlé, MA; Lantero, A; Pílar-Cuellar, F; Roques, BP; Santillán, R; Tramullas, M; Valdizán, E | 1 |
| Akbarali, HI; Dewey, WL; Komla, E; Obeng, S; Selley, DE; Stevens, DL; Wang, H; Zhang, Y; Zheng, Y | 1 |
| Doellgast, GJ; Meis, PJ | 1 |
| Raine, DN | 1 |
1 review(s) available for phenylalanine and morphine
| Article | Year |
|---|---|
[Enkephalinase mechanisms of tolerance of analgetic action of opioids. Effects of D-phenylalanine and naloxone].
Topics: Animals; Drug Resistance; Drug Tolerance; Mice; Morphine; Naloxone; Neprilysin; Opioid Peptides; Phenylalanine; Rabbits; Rats; Rats, Wistar | 1994 |
1 trial(s) available for phenylalanine and morphine
| Article | Year |
|---|---|
Studies on the relationship between 5-hydroxytryptamine turnover in brain and tolerance and physical dependence in mice.
Topics: Animals; Aspirin; Brain; Cyclazocine; Drug Tolerance; Fenclonine; Humans; Levorphanol; Male; Methadone; Mice; Morphinans; Morphine; Morphine Dependence; Nalorphine; Pargyline; Pentazocine; Phenylalanine; Physostigmine; Placebos; Serotonin; Substance Withdrawal Syndrome | 1971 |
63 other study(ies) available for phenylalanine and morphine
| Article | Year |
|---|---|
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Studies of the possible role of brain endorphins in pentobarbital anesthesia and toxicity in mice.
Topics: Animals; Brain; Endorphins; Enkephalins; Leucine; Male; Mice; Morphine; Naloxone; Naltrexone; Pentobarbital; Phenylalanine | 1979 |
Precursor incorporation experiments in Papaver alkaloid biosynthesis. II. Papaver somniferum L.
Topics: Codeine; Glycine; Morphine; Papaver; Phenylalanine; Plants, Medicinal; Thebaine; Urea | 1977 |
Repeated systemic administration of the mixed inhibitor of enkephalin-degrading enzymes, RB101, does not induce either antinociceptive tolerance or cross-tolerance with morphine.
Topics: Analgesics; Animals; Disulfides; Dose-Response Relationship, Drug; Drug Tolerance; Indoles; Male; Mice; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Phenylalanine; Prodrugs; Reaction Time | 1992 |
Lack of physical dependence in mice after repeated systemic administration of the mixed inhibitor prodrug of enkephalin-degrading enzymes, RB101.
Topics: Animals; Behavior, Animal; Body Weight; Disulfides; Injections, Intraventricular; Male; Mice; Morphine; Naloxone; Phenylalanine; Prodrugs; Substance Withdrawal Syndrome; Substance-Related Disorders | 1992 |
Attenuation of the morphine withdrawal syndrome by inhibition of catabolism of endogenous enkephalins in the periaqueductal gray matter.
Topics: Analgesics; Animals; Behavior, Animal; Body Temperature; Body Weight; Corticosterone; Dipeptides; Enkephalins; Hydroxamic Acids; Male; Morphine; Morphine Dependence; Naloxone; Neprilysin; Periaqueductal Gray; Phenylalanine; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Thiorphan | 1992 |
[The analgesic action of d-phenylalanine in combination with morphine or methadone].
Topics: Action Potentials; Analgesics; Animals; Drug Interactions; Male; Methadone; Mice; Morphine; Pain Measurement; Phenylalanine; Rats; Rats, Inbred Strains | 1991 |
Modulation of the antinociceptive effect of morphine by casomorphin derivatives.
Topics: Amino Acid Sequence; Animals; Drug Interactions; Endorphins; Enkephalin, Leucine-2-Alanine; Male; Mice; Mice, Inbred ICR; Molecular Sequence Data; Morphine; Pain; Phenylalanine; Proline; Stereoisomerism; Structure-Activity Relationship | 1991 |
Analgesic responses elicited by endogenous enkephalins (protected by mixed peptidase inhibitors) in a variety of morphine-sensitive noxious tests.
Topics: Analgesics; Animals; Dipeptides; Dose-Response Relationship, Drug; Enkephalins; Hydroxamic Acids; Male; Mice; Morphine; Naloxone; Phenylalanine; Rats; Rats, Inbred Strains | 1991 |
Inhibition of the analgesia inhibitory system by D-phenylalanine and proglumide.
Topics: Acupuncture Analgesia; Analgesia; Animals; Dexamethasone; Drug Tolerance; Male; Morphine; Periaqueductal Gray; Phenylalanine; Proglumide; Rats; Rats, Inbred Strains; Reaction Time | 1991 |
Binding in vivo of selective mu and delta opioid receptor agonists: opioid receptor occupancy by endogenous enkephalins.
Topics: Animals; Brain; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hydroxamic Acids; In Vitro Techniques; Injections; Kinetics; Male; Mice; Morphine; Oligopeptides; Phenylalanine; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Thiorphan | 1989 |
[The opiate mechanism of transcranial electroanalgesia in rats and mice].
Topics: Animals; Drug Tolerance; Electronarcosis; Endorphins; Leucine; Male; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Phenylalanine; Rats; Rats, Inbred Strains; Receptors, Opioid | 1988 |
Differentiation between acupuncture and non-acupuncture points by association with analgesia inhibitory system.
Topics: Acupuncture Therapy; Animals; Brain; Dexamethasone; Electric Stimulation; Evoked Potentials; Hypothalamus, Posterior; Morphine; Naloxone; Neural Inhibition; Nociceptors; Periaqueductal Gray; Phenylalanine; Pituitary Gland; Rabbits; Rats; Rats, Inbred Strains; Sensory Thresholds; Thalamic Nuclei | 1985 |
Neurointermediate lobe transplanted under the kidney capsule modifies the activity of the neurointermediate lobe in situ, but does not respond to opiate treatment.
Topics: Animals; beta-Endorphin; beta-Lipotropin; Endorphins; Histocytochemistry; Kidney; Kinetics; Male; Morphine; Naloxone; Phenylalanine; Pituitary Gland; Pro-Opiomelanocortin; Rats; Rats, Inbred Strains | 1986 |
D-phenylalanine: a putative enkephalinase inhibitor studied in a primate acute pain model.
Topics: Animals; Aspirin; Avoidance Learning; Carboxypeptidases; Drug Interactions; Isomerism; Macaca fascicularis; Male; Morphine; Naloxone; Neprilysin; Pain; Phenylalanine; Protease Inhibitors; Sensory Thresholds; Tolmetin | 1986 |
Motility in Pseudomonas fluorescens with special reference to survival advantage and negative chemotaxis.
Topics: Acetylcholine; Amobarbital; Chemotaxis; Chloramphenicol; Cocaine; Culture Media; Dicumarol; Dimethyl Sulfoxide; Flagella; Indoleacetic Acids; Locomotion; Microscopy, Phase-Contrast; Morphine; Phenols; Phenylalanine; Physostigmine; Pseudomonas; Pyridinium Compounds; Quinacrine; Strychnine; Surface-Active Agents; Urea | 1968 |
Effects of p-chlorophenylalanine and cholinergic antagonists on body temperature changes induced by the administration of morphine to nontolerant and morphine-tolerant rats.
Topics: Animals; Atropine; Body Temperature; Drug Tolerance; Fenclonine; Male; Methyltyrosines; Morphine; Naloxone; Phenylalanine; Rats; Rats, Inbred Strains; Scopolamine; Serotonin; Sympathomimetics; Time Factors | 1972 |
Modification of morphine withdrawal by drugs interacting with humoral mechanisms: some contradictions and their interpretation.
Topics: Animals; Atropine; Behavior, Animal; Drug Interactions; Fenclonine; Heroin; Humans; Indomethacin; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morphine; Motor Activity; Naloxone; Phenylalanine; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Time Factors | 1972 |
Influence of p-chlorophenylalanine on morphine tolerance and physical dependence and regional brain serotonin turnover studies in morphine tolerant-dependent mice.
Topics: Analgesia; Animals; Body Weight; Brain Chemistry; Brain Stem; Drug Tolerance; Fenclonine; Humans; Hypothalamus; Male; Mice; Mice, Inbred Strains; Morphine; Morphine Dependence; Naloxone; Pargyline; Phenylalanine; Rats; Rats, Inbred Strains; Serotonin; Substance Withdrawal Syndrome; Time Factors | 1972 |
The effects of drugs on barbiturate withdrawal convulsions in the rat.
Topics: Animals; Barbiturates; Chlordiazepoxide; Chlorpromazine; Ethanol; Ethosuximide; Female; Humans; Hydrazines; Hypnotics and Sedatives; Meprobamate; Methyltyrosines; Monoamine Oxidase Inhibitors; Morphine; Phenylalanine; Primidone; Rats; Reserpine; Seizures; Serotonin; Substance Withdrawal Syndrome; Tryptophan | 1970 |
Modification of morphine analgesia by drugs affecting adrenergic and tryptaminergic mechanisms.
Topics: Analgesia; Animals; Female; Hot Temperature; Male; Methyltyrosines; Methysergide; Mice; Morphine; Phentolamine; Phenylalanine; Propranolol; Reserpine; Serotonin; Spasm | 1970 |
Effect of chronic administration of morphine on mouse brain aminoacyl-tRNA synthetase and tRNA-amino acid binding.
Topics: Acetylation; Amino Acids; Amino Acyl-tRNA Synthetases; Animals; Arginine; Brain; Carbon Isotopes; Escherichia coli; Leucine; Male; Mice; Mice, Inbred C57BL; Morphine; Phenylalanine; RNA, Transfer | 1973 |
Gas chromatography and mass spectrometry of some trimethylsilyl derivatives of urinary glucuronides.
Topics: Aniline Compounds; Chromatography, Gas; Evaluation Studies as Topic; Glucuronates; Humans; Indoles; Mass Spectrometry; Methane; Methods; Morphine; Phenylacetates; Phenylalanine; Silicon; Structure-Activity Relationship; Toluene | 1974 |
Possible mechanism of action of morphine on brain.
Topics: 5-Hydroxytryptophan; Animals; Brain; Depression, Chemical; Drug Tolerance; Iproniazid; Methyltyrosines; Morphine; Motor Activity; Norepinephrine; Phenylalanine; Rats; Serotonin | 1970 |
The effects of parachlorophenylalanine on nontolerant rats and of cholinergic blocking drugs on toleaant rats to morphine.
Topics: Animals; Atropine; Behavior, Animal; Body Temperature; Drug Tolerance; Morphine; Movement; Parasympatholytics; Phenylalanine; Rats; Scopolamine | 1970 |
Role of biogenic amines in morphine dependence in the rat.
Topics: Animals; Brain; Dihydroxyphenylalanine; Dopamine; Female; Humans; Imipramine; Male; Methyltyrosines; Morphine; Nalorphine; Norepinephrine; Phenylalanine; Rats; Serotonin; Substance-Related Disorders; Thiocarbamates | 1970 |
A comparison of the analgesia produced by morphine and the sympathomimetic drugs.
Topics: Amphetamine; Analgesia; Animals; Iproniazid; Mice; Morphine; Phenylalanine; Reaction Time; Reserpine; Serotonin; Sympathomimetics; Tyrosine | 1970 |
Brain serotonin turnover in morphine tolerant and dependent mice.
Topics: Animals; Brain; Brain Chemistry; Chlorine; Drug Tolerance; Humans; Hydroxyindoleacetic Acid; Male; Mice; Morphinans; Morphine; Morphine Dependence; Narcotic Antagonists; Pargyline; Phenylalanine; Placebos; Serotonin; Sodium Chloride; Substance Withdrawal Syndrome | 1970 |
Unchanged rate of brain serotonin synthesis during chronic morphine treatment and failure of parachlorophenylalanine to attenuate withdrawal syndrome in mice.
Topics: Animals; Brain; Female; Humans; Mice; Morphinans; Morphine; Motor Activity; Narcotic Antagonists; Phenylalanine; Serotonin; Substance Withdrawal Syndrome | 1970 |
Modification of the hypothermic action of morphine after depletion of brain serotonin and catecholamines.
Topics: Analysis of Variance; Animals; Body Temperature; Brain Chemistry; Catecholamines; Hypothermia; Male; Methyltyrosines; Morphine; Phenylalanine; Rats; Serotonin | 1971 |
Antagonism of the analgesic effect of morphine and other drugs by p-chlorophenylalanine, a serotonin depletor.
Topics: Analgesia; Animals; Brain; Codeine; Dextropropoxyphene; Electroshock; Male; Methadone; Morphine; Pain; Phenylalanine; Rats; Serotonin; Serotonin Antagonists | 1968 |
Morphine tolerance, physical dependence, and synthesis of brain 5-hydroxytryptamine.
Topics: Animals; Antimetabolites; Brain; Cycloheximide; Depression, Chemical; Drug Tolerance; Humans; Mice; Morphine; Morphine Dependence; Movement Disorders; Narcotic Antagonists; Pargyline; Phenylalanine; Serotonin; Substance Withdrawal Syndrome | 1968 |
D-phenylalanine and other enkephalinase inhibitors as pharmacological agents: implications for some important therapeutic application.
Topics: Acupuncture Therapy; Animals; Drug Tolerance; Enkephalin, Methionine; Enkephalins; Humans; Morphine; Morphine Dependence; Neprilysin; Nociceptors; Pain; Phenylalanine; Protease Inhibitors; Receptors, Opioid | 1982 |
A comparison of the effects of morphine, enkephalin, kyotorphin and D-phenylalanine on rat central neurones.
Topics: Animals; Brain; Cerebral Cortex; Endorphins; Enkephalin, Methionine; Globus Pallidus; Iontophoresis; Male; Morphine; Naloxone; Neurons; Phenylalanine; Rats | 1983 |
Antagonism of stress-induced analgesia by D-phenylalanine, an anti-enkephalinase.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Male; Morphine; Phenylalanine; Physical Exertion; Rats | 1980 |
Cross-tolerance between D-amino acids and morphine in mice.
Topics: Animals; Drug Tolerance; Leucine; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Morphine; Motor Activity; Nociceptors; Phenylalanine; Stereoisomerism | 1981 |
Long-term treatment of rats with morphine decreases in vitro biosynthesis in and release of beta-endorphin from intermediate/posterior lobes of pituitary.
Topics: Animals; Endorphins; Haloperidol; Male; Molecular Weight; Morphine; Phenylalanine; Pituitary Gland; Pituitary Gland, Posterior; Rats; Time Factors | 1980 |
Enkephalin mydriasis in mice.
Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Mydriatics; Naloxone; Phenylalanine | 1980 |
Antinociceptive effect of peripheral segmental electrical stimulation in the rat.
Topics: Animals; Electric Stimulation; Male; Morphine; Naloxone; Nociceptors; Phenylalanine; Rats; Reaction Time; Serotonin; Thoracic Surgery | 1980 |
Effect of L- and D-amino acids on analgesia and locomotor activity of mice: their interaction with morphine.
Topics: Amino Acids; Animals; Dose-Response Relationship, Drug; Leucine; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Morphine; Motor Activity; Nociceptors; Phenylalanine; Stereoisomerism | 1980 |
Implication of endogenous opioid system in the learned helplessness model of depression.
Topics: Animals; Antidepressive Agents, Tricyclic; Avoidance Learning; Depression; Electroshock; Endorphins; Enkephalins; Helplessness, Learned; Hydroxamic Acids; Imipramine; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Neprilysin; Phenylalanine; Protease Inhibitors; Rats; Rats, Wistar | 1995 |
A selective CCKB receptor antagonist potentiates, mu-, but not delta-opioid receptor-mediated antinociception in the formalin test.
Topics: Analgesics; Animals; Disulfides; Enkephalins; Formaldehyde; Indoles; Male; Meglumine; Mice; Morphine; Naloxone; Naltrexone; Pain Measurement; Phenylalanine; Receptors, Cholecystokinin; Receptors, Opioid, delta; Receptors, Opioid, mu | 1995 |
Inhibition of morphine withdrawal by the association of RB 101, an inhibitor of enkephalin catabolism, and the CCKB antagonist PD-134,308.
Topics: Analgesics; Animals; Behavior, Animal; Binding, Competitive; Body Temperature; Diprenorphine; Disulfides; Drug Combinations; Drug Synergism; Enkephalins; Indoles; Male; Meglumine; Mice; Morphine; Motor Activity; Naloxone; Phenylalanine; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Substance Withdrawal Syndrome; Weight Loss | 1995 |
Phe1-substituted beta-casomorphin-5 analogues with analgesic activity.
Topics: Amino Acid Sequence; Analgesics; Animals; Disease Models, Animal; Drug Tolerance; Endorphins; Male; Molecular Sequence Data; Morphine; Pain; Peptide Fragments; Phenylalanine; Rats; Rats, Wistar; Vocalization, Animal | 1994 |
Antinociceptive response induced by mixed inhibitors of enkephalin catabolism in peripheral inflammation.
Topics: Analgesics; Animals; Disulfides; Enkephalins; Hydroxamic Acids; Inflammation; Injections, Intraventricular; Male; Morphine; Naloxone; Narcotic Antagonists; Neprilysin; Pain; Pain Measurement; Phenylalanine; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley | 1994 |
Effects of opioids and non-opioids on c-Fos-like immunoreactivity induced in rat lumbar spinal cord neurons by noxious heat stimulation.
Topics: Analgesia; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disulfides; Drug Interactions; Drug Tolerance; Hot Temperature; Immunohistochemistry; Injections, Intravenous; Male; Morphine; Neurons; Phenylalanine; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Cord | 1994 |
[The enkephalinase mechanisms of the resistance and tolerance to the analgesic effect of morphine in rats. Differences in the effects of the action of D-phenylalanine in morphine-sensitive, morphine-tolerant and morphine-resistant rats].
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Drug Resistance; Drug Tolerance; Male; Morphine; Neprilysin; Pain; Phenylalanine; Rats; Rats, Wistar; Time Factors | 1993 |
Unlike morphine the endogenous enkephalins protected by RB101 are unable to establish a conditioned place preference in mice.
Topics: Animals; Conditioning, Operant; Disulfides; Drug Interactions; Enkephalins; Enzyme Inhibitors; Male; Mice; Morphine; Naloxone; Phenylalanine; Prodrugs; Substance-Related Disorders | 1993 |
Similar decrease in spontaneous morphine abstinence by methadone and RB 101, an inhibitor of enkephalin catabolism.
Topics: Analgesics; Animals; Disulfides; Drug Combinations; Enkephalins; Indoles; Male; Meglumine; Methadone; Morphine; Naloxone; Phenylalanine; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Substance Withdrawal Syndrome | 1996 |
Similar involvement of several brain areas in the antinociception of endogenous and exogenous opioids.
Topics: Analgesia; Analgesics, Opioid; Animals; Brain; Disulfides; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; Opioid Peptides; Phenylalanine; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley | 1996 |
RB 101, a purported pro drug inhibitor of enkephalin metabolism, is antinociceptive in pregnant mice.
Topics: Analgesics; Analgesics, Opioid; Animals; Depression, Chemical; Disulfides; Enkephalins; Female; Mice; Morphine; Naloxone; Narcotic Antagonists; Pain Threshold; Phenylalanine; Pregnancy; Pregnancy, Animal; Prodrugs; Respiration | 1997 |
Absence of opiate rewarding effects in mice lacking dopamine D2 receptors.
Topics: Animals; Behavior, Addictive; Blotting, Northern; Disulfides; Enzyme Inhibitors; Locomotion; Mice; Morphine; Phenylalanine; Receptors, Dopamine D2; Reward; Substance-Related Disorders | 1997 |
Delta9-tetrahydrocannabinol releases and facilitates the effects of endogenous enkephalins: reduction in morphine withdrawal syndrome without change in rewarding effect.
Topics: Analgesics; Animals; Binding, Competitive; Conditioning, Psychological; Diprenorphine; Disulfides; Dronabinol; Drug Interactions; Enkephalin, Methionine; Extracellular Space; Male; Mice; Morphine; Motor Activity; Narcotic Antagonists; Narcotics; Neurons; Nociceptors; Nucleus Accumbens; Phenylalanine; Psychotropic Drugs; Reward; Substance Withdrawal Syndrome; Tritium | 2001 |
Facilitation of enkephalins catabolism inhibitor-induced antinociception by drugs classically used in pain management.
Topics: Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Disulfides; Enkephalins; Enzyme Inhibitors; Formaldehyde; Injections, Intravenous; Injections, Subcutaneous; Male; Mice; Morphine; Neprilysin; Pain; Pain Measurement; Phenylalanine; Pressure; Rats; Rats, Sprague-Dawley; Reaction Time | 2001 |
RB101(S), a dual inhibitor of enkephalinases does not induce antinociceptive tolerance, or cross-tolerance with morphine: a c-Fos study at the spinal level.
Topics: Analgesics; Animals; Disulfides; Drug Tolerance; Enkephalins; Enzyme Inhibitors; Male; Morphine; Phenylalanine; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Cord | 2002 |
STUDIES ON MORPHINE. III. ACTION OF METABOLIC PRECURSORS TO SEROTONIN AND NORADRENALINE AND RELATED SUBSTANCES ON THE "ABSTINENCE SYNDROME" TO MORPHINE ON WHITE MICE.
Topics: Brain; Catecholamines; Dihydroxyphenylalanine; Ergot Alkaloids; Iproniazid; Kynurenine; Lysergic Acid Diethylamide; Methyldopa; Mice; Morphine; Nalorphine; Norepinephrine; ortho-Aminobenzoates; Pharmacology; Phenylalanine; Research; Serotonin; Shikimic Acid; Toxicology; Tryptophan; Tyrosine | 1963 |
Opioid control of MAP kinase cascade.
Topics: Cell Line; Dipeptides; Epidermal Growth Factor; ErbB Receptors; Etorphine; Humans; Ligands; MAP Kinase Signaling System; Morphine; Naloxone; Narcotics; Oligopeptides; Phenylalanine; Phosphorylation; Receptors, sigma; Thiophenes; Transfection | 2004 |
Blockade of morphine-induced behavioral sensitization by a combination of amisulpride and RB101, comparison with classical opioid maintenance treatments.
Topics: Amisulpride; Animals; Behavior, Animal; Buprenorphine; Disulfides; Male; Methadone; Mice; Morphine; Motor Activity; Opioid-Related Disorders; Phenylalanine; Sulpiride | 2007 |
Use of preproenkephalin knockout mice and selective inhibitors of enkephalinases to investigate the role of enkephalins in various behaviours.
Topics: Analysis of Variance; Animals; Behavior, Animal; CD13 Antigens; Disulfides; Dose-Response Relationship, Drug; Enkephalins; Enzyme Inhibitors; Injections, Intravenous; Mice; Mice, Inbred DBA; Mice, Knockout; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Neprilysin; Phenylalanine; Protein Precursors; Swimming | 2008 |
TGF-β and opioid receptor signaling crosstalk results in improvement of endogenous and exogenous opioid analgesia under pathological pain conditions.
Topics: Adenylyl Cyclase Inhibitors; Analgesia; Analgesics, Opioid; Animals; Disulfides; Hyperalgesia; Infusions, Subcutaneous; Membrane Proteins; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Neuralgia; Peripheral Nerve Injuries; Phenylalanine; Receptors, Opioid, delta; Receptors, Opioid, mu; Sciatic Nerve; Signal Transduction; Spinal Cord; Transforming Growth Factor beta | 2014 |
Methylation Products of 6β- N-Heterocyclic Substituted Naltrexamine Derivatives as Potential Peripheral Opioid Receptor Modulators.
Topics: Analgesics, Opioid; Animals; CHO Cells; Constipation; Cricetulus; Diarrhea; Drug Partial Agonism; Gastrointestinal Agents; Gastrointestinal Transit; Imidazoles; Methylation; Mice; Molecular Docking Simulation; Morphine; Naltrexone; Narcotic Antagonists; Nociception; Phenylalanine; Quaternary Ammonium Compounds; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2018 |
Use of specific inhibitors to disciminate alkaline phosphatase isoenzymes originating from human liver, placenta and intestine: absence of meconial alkaline phosphatase in maternal serum.
Topics: Alkaline Phosphatase; Amniotic Fluid; Female; Humans; Intestines; Isoenzymes; Liver; Maternal-Fetal Exchange; Meconium; Phenylalanine; Placenta; Pregnancy; Tetramisole | 1979 |
Inherited metabolic disease.
Topics: Albumins; Amino Acid Metabolism, Inborn Errors; Chromatography; Clinical Laboratory Techniques; Costs and Cost Analysis; Cystic Fibrosis; Evaluation Studies as Topic; Galactosemias; Genetic Counseling; Humans; Hyperlipidemias; Infant; Infant, Newborn; Iron; Mass Screening; Meconium; Metabolism, Inborn Errors; Phenylalanine; Phenylketonurias | 1974 |