phenylalanine has been researched along with methotrexate in 41 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (39.02) | 18.7374 |
| 1990's | 16 (39.02) | 18.2507 |
| 2000's | 6 (14.63) | 29.6817 |
| 2010's | 2 (4.88) | 24.3611 |
| 2020's | 1 (2.44) | 2.80 |
| Authors | Studies |
|---|---|
| Kaufman, S; Milstien, S | 2 |
| Cotton, RG; Schlesinger, P; Watson, BM | 1 |
| Hilton, MA; Kmetz, DR; Patel, CC | 1 |
| Dhondt, JL; Farriaux, JP; Hayte, JM; Mazingue, F; Millot, F; Taret, S | 1 |
| Muñoz, M; Perán, S; Saiz, MT | 1 |
| McIvor, RS; Simonsen, CC | 1 |
| Banerjee, D; Bertino, JR; Dicker, AP; Schweitzer, BI; Volkenandt, M | 1 |
| Appleman, JR; Blakley, RL; Delcamp, TJ; Freisheim, JH; Prendergast, NJ | 1 |
| Bertolone, S; Hilton, MA; Patel, CC | 1 |
| Benkovic, SJ; Singh, UC | 1 |
| Sprecher-Goldberger, S | 1 |
| Sirotnak, FM | 1 |
| Galt, RM; Knock, FE; Oester, YT; Sylvester, R | 1 |
| Radnay, J; Rozenszajn, LA | 1 |
| Antonioli, JA; Robinson, JW; Vannotti, A | 1 |
| Lo, GS; Longenecker, JB | 1 |
| Newman, EM; Nierenberg, DW; Santi, DV | 1 |
| Bertolone, SJ; Clark, LW; Hilton, MA; Kmetz, DR; Patel, CC | 1 |
| Baer, T; Haag-Zeino, B; Huennekens, FM; Montejano, YD; Vitols, KS | 1 |
| Appleman, JR; Blakley, RL; Nakano, T; Spencer, HT | 1 |
| Appleman, JR; Blakley, RL; Chunduru, SK; Cody, V; Luft, JR; Pangborn, W | 1 |
| Appleman, JR; Blakley, RL; Nakano, T | 1 |
| Appleman, JR; Blakley, RL; Chunduru, SK | 1 |
| Page, M; Perron, MJ | 1 |
| Adams, J; Evenson, DA; McIvor, RS; Wagner, CR | 1 |
| Blumenkopf, TA; Cory, M; Elwell, L; Laethem, RM; Moxham, CP; Ray, PH; Smith, GK; Walton, LM | 1 |
| Banks, S; Blumenkopf, TA; Cory, M; Humphreys, J; Laethem, RM; Miller, J; Moxham, CP; Mullin, R; Ray, PH; Smith, GK; Walton, LM; Wolfe, LA | 1 |
| Huennekens, FM | 1 |
| Gao, F; Goldman, ID; Zhao, R | 1 |
| Hamstra, DA; Maybaum, J; Pagé, M; Rehemtulla, A | 1 |
| Chen, Y; Hao, XK; Shi, PT; Tao, QY; Zhang, YH | 1 |
| Amo, S; Bargatze, RF; Benson, E; Cao, J; De Laszlo, SE; Detmers, PA; Egger, LA; Hagmann, WK; Kidambi, U; Kopka, IE; Lanza, T; Lin, LS; Lingham, R; McCauley, E; Mumford, RA; Pikounis, B; Schmidt, JA; Tong, S; Van Riper, G; Warwood, S; Young, DN | 1 |
| Jung, S; Lee, S | 1 |
| KUKRAL, JC; NORA, PF; PRESTON, FW | 1 |
| Bertino, JR; Bornmann, WG; Deckert, PM; Franke, J; Keilholz, U; Old, LJ; Ritter, G; Thiel, E; Welt, S; Williams, C | 1 |
| Bai, YJ; Hao, XK; Liu, JY; Wu, GJ; Yin, Y; Yue, QH | 1 |
| DeGroot, J; Hanemaaijer, R; Huizinga, TW; Kraan, MC; Tchetverikov, I; van El, B | 1 |
| Kwon, I; Zheng, S | 1 |
| Benkovic, SJ; Bhattacharya, C; Chen, S; Fahmi, NE; Hecht, SM; Jin, Y; Wang, L | 1 |
| Fukuo, Y; Futamura, G; Hiramatsu, R; Hu, N; Kashiwagi, H; Kawabata, S; Miyatake, SI; Suzuki, M; Takata, T; Takeuchi, K; Tanaka, H; Wanibuchi, M; Watanabe, T; Yoshimura, K | 1 |
1 trial(s) available for phenylalanine and methotrexate
| Article | Year |
|---|---|
Leflunomide and methotrexate reduce levels of activated matrix metalloproteinases in complexes with alpha2 macroglobulin in serum of rheumatoid arthritis patients.
Topics: Aged; alpha-Macroglobulins; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Down-Regulation; Enzyme Inhibitors; Female; Humans; Isoxazoles; Leflunomide; Male; Matrix Metalloproteinases; Methotrexate; Middle Aged; Multiprotein Complexes; Phenylalanine; Statistics, Nonparametric; Thiophenes | 2008 |
40 other study(ies) available for phenylalanine and methotrexate
| Article | Year |
|---|---|
Studies on the phenylalanine hydroxylase system in liver slices.
Topics: Animals; Ascorbic Acid; Dithiothreitol; Fenclonine; Folic Acid Antagonists; Glutathione; In Vitro Techniques; Kinetics; Liver; Mercaptoethanol; Methotrexate; Phenylalanine; Phenylalanine Hydroxylase; Rats; Structure-Activity Relationship; Time Factors | 1975 |
Studies on the phenylalanine hydroxylase system in vivo. An in vivo assay based on the liberation of deuterium or tritium into the body water from ring-labeled L-phenylalanine.
Topics: Animals; Body Water; Deuterium; Fenclonine; Isotope Labeling; Kinetics; Methotrexate; Molecular Conformation; Phenylalanine; Phenylalanine Hydroxylase; Rats; Spectrophotometry, Ultraviolet; Time Factors; Tritium | 1975 |
Dihydroxanthopterinuria in phenylketonuria and lethal hyperphenylalaninemia patients.
Topics: Amino Acid Metabolism, Inborn Errors; Electrophoresis; Humans; Methotrexate; Phenylalanine; Phenylketonurias; Pterins; Xanthine Oxidase; Xanthopterin | 1977 |
Plasma amino acids during high-dose methotrexate-citrovorum "rescue".
Topics: Adult; Amino Acids; Cysteine; Humans; Kinetics; Leucovorin; Male; Methotrexate; Osteosarcoma; Phenylalanine | 1976 |
[High-dose methotrexate and hyperphenylalaninemia].
Topics: Adolescent; Biopterins; Child; Child, Preschool; Humans; Hydroxylation; Lymphoma, Non-Hodgkin; Methotrexate; Phenylalanine; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1991 |
Rapid and steady-state amino acid transport in perfused human fibroblasts and colon adenocarcinoma cells: effects of methotrexate.
Topics: Adenocarcinoma; Amino Acids; Biological Transport; Colonic Neoplasms; Fibroblasts; Humans; Methotrexate; Phenylalanine; Serine; Tumor Cells, Cultured | 1990 |
Isolation and characterization of a variant dihydrofolate reductase cDNA from methotrexate-resistant murine L5178Y cells.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Division; Cell Line; Cloning, Molecular; Cricetinae; DNA; Drug Resistance; Gene Expression Regulation; Methotrexate; Mice; Molecular Sequence Data; Phenylalanine; Plasmids; Polymerase Chain Reaction; Tetrahydrofolate Dehydrogenase; Transcription, Genetic; Transfection; Tryptophan | 1990 |
Identification and characterization of a mutation in the dihydrofolate reductase gene from the methotrexate-resistant Chinese hamster ovary cell line Pro-3 MtxRIII.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Cell Line; Cricetinae; DNA; DNA-Directed DNA Polymerase; Drug Resistance; Female; Gene Amplification; Kinetics; Leucine; Methotrexate; Molecular Sequence Data; Molecular Structure; Mutation; Ovary; Phenylalanine; Taq Polymerase; Tetrahydrofolate Dehydrogenase | 1990 |
Effects of conversion of phenylalanine-31 to leucine on the function of human dihydrofolate reductase.
Topics: Binding Sites; Folic Acid; Humans; Kinetics; Leucine; Methotrexate; Mutation; NADP; Phenylalanine; Recombinant Proteins; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim; X-Ray Diffraction | 1989 |
Daily profiles of plasma phenylalanine and tyrosine in patients with osteogenic sarcoma during treatment with high-dose methotrexate-citrovorum rescue.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Combined Modality Therapy; Female; Humans; Leg; Leucovorin; Male; Methotrexate; Osteosarcoma; Phenylalanine; Time Factors; Tyrosine | 1989 |
A free-energy perturbation study of the binding of methotrexate to mutants of dihydrofolate reductase.
Topics: Binding Sites; Chemical Phenomena; Chemistry, Physical; Computer Simulation; Methotrexate; Mutation; Phenylalanine; Tetrahydrofolate Dehydrogenase; Tyrosine; Valine | 1988 |
The existence of two different metabolic patterns for the synthesis of RNA viruses.
Topics: Adenine; Animals; Antimetabolites; Chick Embryo; Culture Media; Dactinomycin; Enterovirus; Fibroblasts; Formates; Histones; Influenza A virus; Methotrexate; Nucleosides; Orotic Acid; Phenylalanine; Puromycin; Radiation Effects; RNA Viruses; RNA, Viral; Thymidine; Ultraviolet Rays; Uridine | 1966 |
High dihydrofolate reductase levels in Diplococcus pneumoniae after mutation in the structural gene: biochemical and immunological evidence for increased synthesis.
Topics: Animals; Antigens, Bacterial; Bacterial Proteins; Carbon Isotopes; Chloramphenicol; Chromosome Mapping; Drug Resistance, Microbial; Female; Folic Acid; Genes; Genetics, Microbial; Hydrogen-Ion Concentration; Immune Sera; Immunodiffusion; Methotrexate; Mutation; Neutralization Tests; Phenylalanine; Precipitin Tests; Rabbits; Recombination, Genetic; Spectrophotometry; Streptococcus pneumoniae; Tetrahydrofolate Dehydrogenase; Transformation, Genetic | 1971 |
In vitro estimate of sensitivity of individual human tumors to antitumor agents.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Arsenicals; Benzoates; Breast Neoplasms; Carbon Radioisotopes; Carcinoma; Carcinoma, Ehrlich Tumor; Cattle; Depression, Chemical; DNA, Neoplasm; Female; Fluorouracil; Humans; In Vitro Techniques; Iodoacetates; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Lymphoma, Non-Hodgkin; Mechlorethamine; Methotrexate; Mice; Neoplasms; Phenylalanine; Succinate Dehydrogenase; Thymidine; Tritium | 1974 |
The effect of methotrexate on transformation and mitosis of normal human blood lymphocytes in vitro.
Topics: Blood Proteins; Carbon Radioisotopes; Cells, Cultured; Densitometry; DNA; Humans; Lectins; Lymphocyte Activation; Lymphocytes; Methotrexate; Mitosis; Phenylalanine; RNA; Thymidine; Time Factors; Tritium; Uridine | 1974 |
The effect of oral methotrexate on the rat intestine.
Topics: Animals; Biological Transport; Biopsy; Glucose; Intestinal Absorption; Intestinal Mucosa; Lactates; Male; Methotrexate; Oxygen Consumption; Phenylalanine; Rats | 1966 |
Induction of an experimental phenylketonuria-like condition in infant rats during the first 2 weeks after birth.
Topics: Animals; Animals, Newborn; Diet; Disease Models, Animal; Female; Fenclonine; Humans; Male; Methotrexate; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Rats; Tyrosine | 1981 |
Selective killing of transformed cells by methotrexate with histidine deprivation or with alpha-amino alcohols.
Topics: Animals; Cell Division; Cell Survival; Histidine; Histidinol; Imidazoles; Methotrexate; Mice; Mice, Inbred BALB C; Phenylalanine; Tyrosine | 1983 |
Plasma phenylalanine: tyrosine ratios during high-dose methotrexate-citrovorum "rescue".
Topics: Adolescent; Bone Neoplasms; Child; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma; Phenylalanine; Time Factors; Tyrosine | 1982 |
Methotrexate-alpha-phenylalanine: optimization of methotrexate prodrug for activation by carboxypeptidase A-monoclonal antibody conjugate.
Topics: Antibodies, Monoclonal; Antineoplastic Agents; Carboxypeptidases; Carboxypeptidases A; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Humans; Hydrolysis; Indicators and Reagents; Lung Neoplasms; Methotrexate; Phenylalanine; Prodrugs; Tumor Cells, Cultured | 1995 |
Critical role of phenylalanine 34 of human dihydrofolate reductase in substrate and inhibitor binding and in catalysis.
Topics: Ammonium Sulfate; Catalysis; Chemical Precipitation; Enzyme Stability; Folic Acid; Humans; Hydrogen-Ion Concentration; Kinetics; Methotrexate; Mutagenesis, Site-Directed; NADP; Phenylalanine; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 1994 |
Methotrexate-resistant variants of human dihydrofolate reductase. Effects of Phe31 substitutions.
Topics: Amino Acid Sequence; Crystallography, X-Ray; Drug Resistance; Enzyme Stability; Genetic Therapy; Genetic Variation; Humans; Kinetics; Methotrexate; Models, Structural; Models, Theoretical; Mutagenesis, Site-Directed; NADP; Phenylalanine; Protein Conformation; Protein Denaturation; Protein Folding; Recombinant Proteins; Tetrahydrofolate Dehydrogenase | 1994 |
Methotrexate-insensitive mutants of human dihydrofolate reductase (hDHFR) constructed by site-directed mutagenesis at phenylalanine 34.
Topics: Amino Acid Sequence; Cloning, Molecular; Drug Resistance; Escherichia coli; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Methotrexate; Mutagenesis, Site-Directed; Phenylalanine; Recombinant Proteins; Tetrahydrofolate Dehydrogenase | 1993 |
Kinetic investigation of methotrexate resistant human dihydrofolate reductase (hDHFR) mutants at Phe31.
Topics: Amino Acid Sequence; Drug Resistance; Folic Acid Antagonists; Genetic Variation; Humans; Kinetics; Methotrexate; Mutagenesis, Site-Directed; Phenylalanine; Point Mutation; Recombinant Proteins; Tetrahydrofolate Dehydrogenase | 1993 |
Activation of methotrexate-phenylalanine by monoclonal antibody--carboxypeptidase A conjugate for the specific treatment of ovarian cancer in vitro.
Topics: Antibodies, Monoclonal; Antibodies, Neoplasm; Antimetabolites, Antineoplastic; Carboxypeptidases; Carboxypeptidases A; Female; Humans; Methotrexate; Ovarian Neoplasms; Phenylalanine; Prodrugs; Tumor Cells, Cultured | 1996 |
Methotrexate resistance of mouse dihydrofolate reductase: effect of substitution of phenylalanine-31 by serine or tryptophan.
Topics: Animals; Crystallography, X-Ray; Folic Acid Antagonists; Kinetics; Methotrexate; Mice; Mutagenesis, Site-Directed; Phenylalanine; Serine; Tetrahydrofolate Dehydrogenase; Thermodynamics; Tryptophan | 1996 |
Expression and characterization of human pancreatic preprocarboxypeptidase A1 and preprocarboxypeptidase A2.
Topics: Amino Acid Sequence; Animals; Base Sequence; Carboxypeptidases; Cattle; Cloning, Molecular; DNA Primers; Enzyme Precursors; Enzyme Stability; Gene Expression; Humans; Kinetics; Methotrexate; Molecular Sequence Data; Neoplasms; Pancreas; Phenylalanine; Prodrugs; Rats; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Substrate Specificity; Temperature | 1996 |
Toward antibody-directed enzyme prodrug therapy with the T268G mutant of human carboxypeptidase A1 and novel in vivo stable prodrugs of methotrexate.
Topics: Animals; Antibodies; Antimetabolites, Antineoplastic; Binding Sites; Carboxypeptidases; Carboxypeptidases A; Cattle; Drug Delivery Systems; Drug Design; Drug Stability; HT29 Cells; Humans; Hydrolysis; Isoenzymes; Kinetics; Macromolecular Substances; Methotrexate; Models, Molecular; Mutagenesis; Pancreas; Pancreatic Juice; Phenylalanine; Prodrugs | 1997 |
Development of methotrexate alpha-peptides as prodrugs for activation by enzyme-monoclonal antibody conjugates.
Topics: Animals; Antineoplastic Agents; Biotransformation; Carboxypeptidases; Drug Resistance, Neoplasm; Humans; Hydrolysis; Immunoconjugates; Methotrexate; Phenylalanine; Prodrugs; Tumor Cells, Cultured | 1997 |
Discrimination among reduced folates and methotrexate as transport substrates by a phenylalanine substitution for serine within the predicted eighth transmembrane domain of the reduced folate carrier.
Topics: Amino Acid Substitution; Animals; Antimetabolites, Antineoplastic; Biological Transport; Carrier Proteins; Cell Division; Chlorides; DNA Mutational Analysis; DNA, Complementary; DNA, Neoplasm; Drug Resistance, Neoplasm; Kinetics; Leucovorin; Leukemia L1210; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Phenotype; Phenylalanine; Reduced Folate Carrier Protein; Serine; Transfection; Tumor Cells, Cultured | 1999 |
Expression of endogenously activated secreted or cell surface carboxypeptidase A sensitizes tumor cells to methotrexate-alpha-peptide prodrugs.
Topics: Antineoplastic Agents; Carboxypeptidases; Carboxypeptidases A; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Methotrexate; Phenylalanine; Prodrugs; Time Factors; Trypsin; Tumor Cells, Cultured | 2000 |
[The solid-phase synthesis of methotrexate-alpha-peptides].
Topics: Antineoplastic Agents; History, Medieval; Humans; Male; Methotrexate; Phenylalanine; Prodrugs; Prostatic Neoplasms; Tumor Cells, Cultured | 1997 |
Alpha(4)beta(7)/alpha(4)beta(1) dual integrin antagonists block alpha(4)beta(7)-dependent adhesion under shear flow.
Topics: Animals; Antibodies, Blocking; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Cell Adhesion; Cell Adhesion Molecules; Cyclophosphamide; Doxorubicin; Endothelium, Vascular; Etoposide; Female; Flow Cytometry; Humans; Immunoglobulin G; Immunoglobulins; Integrin alpha4beta1; Integrins; Ligands; Lymphocytes; Methotrexate; Mice; Mice, Inbred BALB C; Mucoproteins; Peyer's Patches; Phenylalanine; Receptors, Lymphocyte Homing; Recombinant Fusion Proteins; Rheology | 2002 |
Enantioseparation using cyclosophoraoses as a novel chiral additive in capillary electrophoresis.
Topics: Electrophoresis, Capillary; Glucans; Methotrexate; Molecular Structure; Phenylalanine; Rhizobium; Stereoisomerism; Terbutaline; Thyroxine | 2003 |
INFUSION CHEMOTHERAPY FOR ABDOMINAL MALIGNANCIES. METHODOLOGY AND PRELIMINARY REPORT.
Topics: Abdominal Neoplasms; Angiography; Antimetabolites; Antineoplastic Agents; Aorta; Aorta, Abdominal; Brachial Artery; Catheterization; Drug Therapy; Femoral Artery; Fluoroscopy; Fluorouracil; Hepatic Artery; Humans; Methotrexate; Palliative Care; Perfusion; Phenylalanine; Thiotepa | 1964 |
Specific tumour localisation of a huA33 antibody--carboxypeptidase A conjugate and activation of methotrexate-phenylalanine.
Topics: Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Carboxypeptidases A; Colonic Neoplasms; Female; Humans; Iodine Radioisotopes; Membrane Glycoproteins; Methotrexate; Mice; Mice, Nude; Phenylalanine; Prodrugs; Survival Rate; Transplantation, Heterologous; Tumor Cells, Cultured | 2004 |
In vitro and in vivo prodrug therapy of prostate cancer using anti-gamma-Sm-scFv/hCPA fusion protein.
Topics: Animals; Antibodies, Neoplasm; Carboxypeptidases A; Cell Cycle; Cell Line, Tumor; Drug Delivery Systems; Humans; Immunoglobulin Variable Region; Male; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Neoplastic Stem Cells; Phenylalanine; Prodrugs; Prostate-Specific Antigen; Prostatic Neoplasms; Recombinant Fusion Proteins; Transplantation, Heterologous | 2006 |
Controlling enzyme inhibition using an expanded set of genetically encoded amino acids.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Computer Simulation; Escherichia coli; Folic Acid; Folic Acid Antagonists; Methotrexate; Mice; Models, Molecular; Molecular Sequence Data; Naphthalenes; Phenylalanine; Protein Binding; Protein Engineering; Recombinant Proteins; Sequence Alignment; Tetrahydrofolate Dehydrogenase; Tryptophan | 2013 |
Fluorescent biphenyl derivatives of phenylalanine suitable for protein modification.
Topics: Biocatalysis; Biphenyl Compounds; Chemical Phenomena; Enzyme Inhibitors; Escherichia coli; Escherichia coli Proteins; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Folic Acid Antagonists; Indicators and Reagents; Isomerism; Methotrexate; Mutagenesis, Site-Directed; Mutant Proteins; Peptide Fragments; Phenylalanine; Recombinant Proteins; Spectrometry, Fluorescence; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tetrahydrofolate Dehydrogenase; Trimethoprim | 2013 |
Efficacy of Boron Neutron Capture Therapy in Primary Central Nervous System Lymphoma: In Vitro and In Vivo Evaluation.
Topics: Animals; Apoptosis; Boron; Boron Neutron Capture Therapy; Brain; Cell Line, Tumor; Cell Survival; Central Nervous System Neoplasms; Cranial Irradiation; Disease Models, Animal; Humans; Lymphoma; Methotrexate; Mice; Phenylalanine; Tissue Distribution | 2021 |