Compounds > phenylalanine

phenylalanine and lumacaftor

phenylalanine has been researched along with lumacaftor in 5 studies

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (40.00)24.3611
2020's3 (60.00)2.80

Authors

AuthorsStudies
Jeon, DK; Jo, S; Khloya, P; Kumar, S; Lee, HK; Namkung, W; Park, J; Seo, Y; Sharma, PK1
Bear, CE; Casavola, V; Laselva, O; Molinski, S1
Aissat, A; Bizard, L; Decrouy, X; Degrugillier, F; Fanen, P; Jiang, C; Prulière-Escabasse, V; Rotin, D; Simon, S; Simonneau, B1
Bailly, B; Day, CJ; Dirr, L; Guillon, P; Haselhorst, T; Jen, FE; Jennings, MP; Mak, J; Spillings, BL; von Itzstein, M1
Baroni, D; Brandas, C; Cichero, E; Ludovico, A; Millo, E; Moran, O; Parodi, A1

Other Studies

5 other study(ies) available for phenylalanine and lumacaftor

ArticleYear
Potentiation of ΔF508- and G551D-CFTR-Mediated Cl- Current by Novel Hydroxypyrazolines.
    PloS one, 2016, Volume: 11, Issue:2

    Topics: Aminopyridines; Animals; Bacterial Proteins; Benzodioxoles; Cell Line; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Chlorides; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Epithelial Cells; Gene Deletion; Genistein; Humans; Luminescent Proteins; Mutation; Nose; Patch-Clamp Techniques; Phenylalanine; Pyrazoles; Rats; Structure-Activity Relationship; Sulfonamides

2016
Correctors of the Major Cystic Fibrosis Mutant Interact through Membrane-Spanning Domains.
    Molecular pharmacology, 2018, Volume: 93, Issue:6

    Topics: Aminopyridines; Benzamides; Benzodioxoles; Cell Line; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; HEK293 Cells; Humans; Mutation; Phenylalanine; Protein Structure, Tertiary; Thiazoles

2018
Phosphorylation of the Chaperone-Like HspB5 Rescues Trafficking and Function of F508del-CFTR.
    International journal of molecular sciences, 2020, Jul-08, Volume: 21, Issue:14

    Topics: Aminophenols; Aminopyridines; Animals; Benzodioxoles; Cell Line; Cell Membrane; Crystallins; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Drug Combinations; Heat-Shock Proteins; HEK293 Cells; Humans; Male; Mice; Molecular Chaperones; Mutation; Phenylalanine; Phosphorylation; Proteasome Endopeptidase Complex; Protein Transport; Quinolones

2020
Multidisciplinary Approaches Identify Compounds that Bind to Human ACE2 or SARS-CoV-2 Spike Protein as Candidates to Block SARS-CoV-2-ACE2 Receptor Interactions.
    mBio, 2021, 03-30, Volume: 12, Issue:2

    Topics: Aminopyridines; Angiotensin-Converting Enzyme 2; Animals; Antiviral Agents; Benzodioxoles; Cell Line; Chlorocebus aethiops; COVID-19 Drug Treatment; Drug Evaluation, Preclinical; Drug Repositioning; Evans Blue; Humans; Molecular Docking Simulation; Phenylalanine; Protein Binding; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Sulfones; Surface Plasmon Resonance; Vero Cells; Virus Attachment; Virus Replication

2021
NBD2 Is Required for the Rescue of Mutant F508del CFTR by a Thiazole-Based Molecule: A Class II Corrector for the Multi-Drug Therapy of Cystic Fibrosis.
    Biomolecules, 2021, 09-28, Volume: 11, Issue:10

    Topics: Aminopyridines; Benzodioxoles; Cell Membrane; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Epithelial Cells; Gene Expression Regulation; HEK293 Cells; Humans; Mutant Proteins; Phenylalanine; Thiazoles

2021