Compounds > phenylalanine

phenylalanine and jte 607

phenylalanine has been researched along with jte 607 in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (58.33)29.6817
2010's3 (25.00)24.3611
2020's2 (16.67)2.80

Authors

AuthorsStudies
Inushima, K; Iwamura, H; Kakutani, M; Takeuchi, K; Wakitani, K1
Aikawa, N; Aiso, S; Fujishima, S; Iwamura, H; Sasaki, J; Wakitani, K1
Jian, MY; Koizumi, T; Kubo, K; Tsushima, K1
Aleshin, AN; Matsuda, H; Miyamoto, Y; Ono, M; Ryugo, M; Sawa, Y1
Iwamura, H; Sato, M; Wakitani, K1
Fukui, K; Maruhashi, J; Tajima, N; Tojo, A; Uesato, N1
Asaga, T; Chujo, K; Taie, S; Ueki, M1
Fukui, K; Maruhashi, J; Tajima, N; Tojo, A; Uesato, N; Watanabe, Y; Yoshida, T1
Allen, E; Borozdenkova, S; Hoshino, S; Jurcevic, S; Mant, TG; Pu, K1
Kakegawa, J; Sakane, N; Suzuki, K; Yoshida, T1
Akinjiyan, FA; Artus-Revel, CG; Beckwith, REJ; Boynton, G; Brittain, SM; Carbone, W; Carbonneau, S; Carl, SH; Chao, JA; Chen, A; Fazal, A; George, EL; Gleim, S; Henault, M; Jenkins, J; Jia, M; Knehr, J; Lohmann, F; Michaud, G; Miller, HR; Molind, GJ; Murphy, J; Passmore, LA; Reece-Hoyes, JS; Rodríguez-Molina, JB; Roma, G; Ross, NT; Salcius, M; Saran, C; Schirle, M; Schuierer, S; Sigoillot, F; Spencer, M; Tallarico, J; Thomas, JR; Turner, J; Wang, Y; Weihofen, WA; Wilbertz, JH; Williams, ET; Xie, K; Zambrowski, M1
Baughman, K; Gutierrez, PA; Sun, Y; Tong, L1

Trials

1 trial(s) available for phenylalanine and jte 607

ArticleYear
Effects of a cytokine inhibitor, JTE-607, on the response to endotoxin in healthy human volunteers.
    International immunopharmacology, 2011, Volume: 11, Issue:11

    Topics: Adolescent; Adult; Biomarkers; C-Reactive Protein; Cohort Studies; Cytokines; Dose-Response Relationship, Drug; Double-Blind Method; Endotoxemia; Enzyme-Linked Immunosorbent Assay; Humans; Infusions, Intravenous; Interleukin 1 Receptor Antagonist Protein; Interleukin-10; Lipopolysaccharides; Male; Middle Aged; Phenylalanine; Piperazines; Young Adult

2011

Other Studies

11 other study(ies) available for phenylalanine and jte 607

ArticleYear
Prophylactic effect of JTE-607 on LPS-induced acute lung injury in rats with CINC-1 inhibition.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2002, Volume: 51, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemokine CXCL1; Chemokines; Chemokines, CXC; Chemotactic Factors; Dexamethasone; Intercellular Signaling Peptides and Proteins; Lipopolysaccharides; Macrophages, Alveolar; Male; Neutrophils; Phenylalanine; Piperazines; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome

2002
Prior burn insult induces lethal acute lung injury in endotoxemic mice: effects of cytokine inhibition.
    American journal of physiology. Lung cellular and molecular physiology, 2003, Volume: 284, Issue:2

    Topics: Acute Disease; Animals; Burns; Chemokine CXCL2; Cytokines; Endotoxemia; Gene Expression; Lipopolysaccharides; Lung; Lung Diseases; Male; Mice; Mice, Inbred BALB C; Monokines; Peroxidase; Phenylalanine; Piperazines; Prednisolone; Survival Analysis; Time Factors; Tumor Necrosis Factor-alpha

2003
JTE-607, a cytokine release blocker, attenuates acid aspiration-induced lung injury in rats.
    European journal of pharmacology, 2004, Mar-19, Volume: 488, Issue:1-3

    Topics: Animals; Bronchoalveolar Lavage Fluid; Cell Count; Cytokines; DNA Primers; Glyceraldehyde-3-Phosphate Dehydrogenases; Interleukin-6; Lung; Male; Neutrophils; Organ Size; Phenylalanine; Piperazines; Pneumonia, Aspiration; Pulmonary Edema; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serum Albumin; Tumor Necrosis Factor-alpha

2004
Pharmacologic preconditioning of JTE-607, a novel cytokine inhibitor, attenuates ischemia-reperfusion injury in the myocardium.
    The Journal of thoracic and cardiovascular surgery, 2004, Volume: 127, Issue:6

    Topics: Animals; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Myocardial Reperfusion; Myocardial Reperfusion Injury; Phenylalanine; Piperazines; Probability; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Survival Rate

2004
Comparative study of glucocorticoids, cyclosporine A, and JTE-607 [(-)-Ethyl-N[3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoyl]-L-phenylalaninate dihydrochloride] in a mouse septic shock model.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 311, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Cyclosporine; Cytokines; Enzyme-Linked Immunosorbent Assay; Glucocorticoids; Immunosuppressive Agents; Leukocyte Count; Lung; Male; Mice; Mice, Inbred BALB C; Peroxidase; Phenylalanine; Piperazines; Platelet Count; Prednisolone; Shock, Septic

2004
JTE-607, a multiple cytokine production inhibitor, ameliorates disease in a SCID mouse xenograft acute myeloid leukemia model.
    Experimental hematology, 2006, Volume: 34, Issue:10

    Topics: Animals; Autocrine Communication; Cell Proliferation; Cytokines; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Humans; Interleukin-8; Leukemia, Myeloid, Acute; Leukocyte Common Antigens; Mice; Mice, SCID; Neoplasm Transplantation; Neoplasms, Experimental; Paracrine Communication; Phenylalanine; Piperazines; Transplantation, Heterologous

2006
JTE-607, an inflammatory cytokine synthesis inhibitor, attenuates ischemia/reperfusion-induced renal injury by reducing neutrophil activation in rats.
    Journal of bioscience and bioengineering, 2008, Volume: 106, Issue:1

    Topics: Animals; Cytokines; Kidney Diseases; Male; Neutrophil Activation; Phenylalanine; Piperazines; Rats; Reperfusion Injury

2008
JTE-607, a multiple cytokine production inhibitor, induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells.
    Cancer science, 2010, Volume: 101, Issue:3

    Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Cytokines; Female; Humans; Leukemia, Myeloid, Acute; Mice; Mice, SCID; Phenylalanine; Piperazines; Vascular Endothelial Growth Factor A

2010
JTE-607, a multiple cytokine production inhibitor, targets CPSF3 and inhibits pre-mRNA processing.
    Biochemical and biophysical research communications, 2019, 10-08, Volume: 518, Issue:1

    Topics: Cell Line; Cleavage And Polyadenylation Specificity Factor; Cytokines; Humans; Models, Biological; Phenylalanine; Piperazines; Prodrugs; RNA Precursors; RNA Processing, Post-Transcriptional

2019
CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing's sarcoma.
    Nature chemical biology, 2020, Volume: 16, Issue:1

    Topics: Animals; Apoptosis; Binding Sites; Carboxylic Ester Hydrolases; Cell Line, Tumor; Cell Survival; Cleavage And Polyadenylation Specificity Factor; HEK293 Cells; Humans; Leukemia, Myeloid, Acute; Male; Mass Spectrometry; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Phenotype; Phenylalanine; Piperazines; Protein Binding; RNA Precursors; RNA, Messenger; RNA, Small Interfering; Sarcoma, Ewing

2020
A real-time fluorescence assay for CPSF73, the nuclease for pre-mRNA 3'-end processing.
    RNA (New York, N.Y.), 2021, Volume: 27, Issue:10

    Topics: Biological Assay; Cell-Free System; Cleavage And Polyadenylation Specificity Factor; Enzyme Assays; Enzyme Inhibitors; Fluorescence; Fluorescent Dyes; Histones; Humans; Models, Molecular; Phenylalanine; Piperazines; Proteolysis; Rhodamines; Ribonucleoprotein, U7 Small Nuclear; RNA 3' End Processing; RNA Precursors; Small Molecule Libraries

2021