phenylalanine has been researched along with glyburide in 50 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (24.00) | 18.2507 |
| 2000's | 33 (66.00) | 29.6817 |
| 2010's | 5 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nishikawa, M; Sato, Y; Shinkai, H; Sukegawa, E | 1 |
| Dan, K; Fujita, T; Hirose, H; Ito, K; Kanda, N; Kato, R; Maruyama, H; Saruta, T; Seto, Y | 1 |
| Dan, K; Fujita, H; Fujita, T; Kato, R; Seto, Y | 1 |
| Brasseur, R; Lins, L; Malaisse, WJ | 1 |
| Fujita, T; Kato, R; Kondo, N; Seto, Y | 1 |
| Kikuchi, M | 1 |
| Akiyoshi, M; Fujitani, S; Ikenoue, T; Kondo, N; Maki, T; Okazaki, K | 1 |
| Akiyoshi, M; Fujitani, S; Ikenoue, T; Kondo, N; Maki, T; Okazaki, K; Tsuchiya, Y | 1 |
| Kikuchi, M; Niki, I; Oka, Y; Sakurada, M; Tsukuda, K | 1 |
| Meyer, M; Panten, U; Schwanstecher, C; Schwanstecher, M | 1 |
| Dunning, BE; Hu, S; Wang, S | 1 |
| Ladrière, L; Laghmich, A; Malaisse, WJ; Malaisse-Lagae, F | 1 |
| Bell, PA; Boettcher, BR; Dunning, BE; Fanelli, B; Geisse, S; Hu, S; Schmitz, R; Wang, S | 1 |
| Hashimoto, Y; Inui, K; Saito, H; Uwai, Y | 1 |
| Hirschberg, Y; Karara, AH; McLeod, JF; Pietri, AO | 1 |
| Landgraf, R | 1 |
| Dunning, BE; Foley, JE; Gatlin, MR; Haas, SJ; Hollander, PA; Schwartz, SL; Zheng, H | 1 |
| Hu, S; Wang, S | 1 |
| Gonoi, T; Ichikawa, K; Kusama, H; Seino, S; Shibasaki, T; Sunaga, Y; Yano, H | 1 |
| Devineni, D; Foley, JE; Horowitz, A; Howell, W; Hsu, CH; Kahn, SE; Ligueros-Saylan, M; McLeod, JF; Montgomery, B | 1 |
| Arakawa, Y; Ebihara, S; Hayashi, Y; Kawamura, W; Kikuchi, M; Morita, T; Ogihara, N; Okamoto, M; Okuda, Y; Sakai, T; Takiguchi, K; Uchida, R; Yamaguchi, J | 1 |
| Hu, S | 1 |
| Ito, S; Kitahara, Y; Mine, T; Miura, K; Takesue, K; Uchida, Y; Wada, R; Yagihashi, S | 1 |
| Kawamori, R; Kitahara, Y; Mine, T; Miura, K; Okano, A | 1 |
| Courtois, P; Jijakli, H; Ladriere, L; Malaisse, WJ; Oguzhan, B; Sener, A | 1 |
| Del Prato, S; Emmons, RP; Guitard, C; Heine, RJ; Keilson, L; Shen, SG | 1 |
| Anderson, DM; Barnett, AH; Morgan, R; Owens, DR; Shelley, S | 1 |
| Haslbeck, M; Jakob, S; Kellerer, M; Linn, T | 1 |
| Baron, MA; Cefalu, W; Fonseca, VA; Gerich, JE; Hsia, S; Kelley, DE; Nestler, JE; Purkayastha, D | 1 |
| Kitahara, Y; Mine, T; Miura, K; Mori, Y; Tajima, N | 1 |
| Berney, T; Bosco, D; Carr, RD; Donath, MY; Maedler, K; Zuellig, RA | 1 |
| Baron, MA; Gerich, J; Jean-Louis, L; Purkayastha, D; Raskin, P | 1 |
| Groop, LC; Honkanen, EH; Isomaa, B; Sarelin, L; Tuomi, T | 1 |
| Aoyagi, I; Fujimori, Y; Fuujimori, Y; Itoh, Y; Kojima, M; Kojima, S; Kusama, H; Mori, Y; Ojima, K; Shibata, N; Tajima, N; Yamazaki, Y | 1 |
| Harada, S; Ito, S; Nakaya, Y; Nomura, M | 1 |
| Erkent, U; Ertunc, M; Guc, MO; Ilhan, M; Iskit, AB; Onur, R | 1 |
| Clark, R; Inoue, T; Nagakura, T; Saeki, T; Shinoda, M; Sugaya, Y; Tanaka, I; Yamamoto, E; Yamazaki, K; Yasuda, N | 1 |
| Bieger, S; Kühner, P; Quast, U; Stephan, D; Winkler, M; Wolff, F | 1 |
| Baron, MA; Gerich, JE; Jean-Louis, L; Marcellari, A; Purkayastha, D; Schwarz, SL | 1 |
| Cicero, AF; D'Angelo, A; Derosa, G; Ferrari, I; Fogari, E; Gravina, A; Salvadeo, S | 2 |
| Akimoto, Y; Aoyagi, K; Kawai, J; Kawakami, H; Kawamori, R; Matsushima, S; Nagamatsu, S; Nakamichi, Y; Ohara-Imaizumi, M; Okamura, T; Watada, H; Watanabe, T | 1 |
| Fujii, M; Inoguchi, T; Kobayashi, K; Maeda, Y; Morinaga, H; Nomura, M; Sasaki, S; Sawada, F; Takayanagi, R; Tsubouchi, H | 1 |
| Akimoto, Y; Kawakami, H; Nagamatsu, S; Ohara-Imaizumi, M; Sawada, H | 1 |
| Inagaki, N; Nagashima, K | 1 |
| Bellomo Damato, A; Giorgino, F; Giorgino, R; Laviola, L; Stefanelli, G | 1 |
| Abdelmoneim, AS; Brocks, DR; Hasenbank, SE; Light, PE; Seubert, JM; Simpson, SH | 1 |
| Fatehi, M; Lang, VY; Light, PE | 1 |
| Chen, M; Guo, Z; Hao, J; Houze, J; Lin, DC; Lopez, E; Luo, J; Ma, Z; Nguyen, K; Rulifson, IC; Tian, B; Tian, L; Tran, T; Wang, Y; Zhang, Y | 1 |
| Bilker, WB; Brensinger, CM; Chiang, C; Han, X; Hennessy, S; Leonard, CE; Li, L | 1 |
6 review(s) available for phenylalanine and glyburide
| Article | Year |
|---|---|
Modulation of insulin secretion in non-insulin-dependent diabetes mellitus by two novel oral hypoglycaemic agents, NN623 and A4166.
Topics: Administration, Oral; Biological Availability; Blood Glucose; Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Glyburide; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Intestinal Absorption; Molecular Structure; Nateglinide; Phenylalanine; Piperidines; Reference Values; Stereoisomerism | 1996 |
Meglitinide analogues in the treatment of type 2 diabetes mellitus.
Topics: Benzamides; Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Glyburide; Humans; Hypoglycemic Agents; Molecular Structure; Nateglinide; Phenylalanine; Piperidines | 2000 |
Treatment of patients over 64 years of age with type 2 diabetes: experience from nateglinide pooled database retrospective analysis.
Topics: Aged; Blood Glucose; Body Mass Index; Comorbidity; Cyclohexanes; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Glyburide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Metformin; Nateglinide; Phenylalanine; Randomized Controlled Trials as Topic; Retrospective Studies | 2003 |
[Continuation 50. Type 2 diabetes: possibilities and limitations of pharmacological therapy].
Topics: 1-Deoxynojirimycin; Acarbose; Aged; Blood Glucose; Carbamates; Contraindications; Cyclohexanes; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Enzyme Inhibitors; Fasting; Follow-Up Studies; Germany; Glucosamine; Glyburide; Glycated Hemoglobin; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemia; Hypoglycemic Agents; Imino Pyranoses; Insulin; Metformin; Middle Aged; Nateglinide; Obesity; Patient Compliance; Phenylalanine; Pioglitazone; Piperidines; Practice Guidelines as Topic; Risk Factors; Rosiglitazone; Sulfonylurea Compounds; Thiazolidinediones; Time Factors | 2003 |
[Progress in therapy for diabetes mellitus--insulin-secretion inducing oral hypoglycemic agents].
Topics: Administration, Oral; Cyclohexanes; Diabetes Mellitus; Glyburide; Humans; Hypoglycemic Agents; Infant, Newborn; Insulin; Insulin Secretion; KATP Channels; Mutation; Nateglinide; Phenylalanine; Stimulation, Chemical; Sulfonylurea Compounds | 2009 |
Variations in tissue selectivity amongst insulin secretagogues: a systematic review.
Topics: Animals; ATP-Binding Cassette Transporters; Carbamates; Cardiovascular Diseases; Cricetinae; Cyclohexanes; Diabetes Mellitus, Type 2; Gliclazide; Glipizide; Glyburide; Humans; Hypoglycemic Agents; Ischemic Preconditioning, Myocardial; Isoindoles; Mice; Muscle, Smooth, Vascular; Myocytes, Cardiac; Nateglinide; Phenylalanine; Piperidines; Potassium Channels, Inwardly Rectifying; Rats; Receptors, Drug; Risk Factors; Sulfonylurea Compounds; Sulfonylurea Receptors; Tolbutamide | 2012 |
13 trial(s) available for phenylalanine and glyburide
| Article | Year |
|---|---|
Modulation of insulin secretion in non-insulin-dependent diabetes mellitus by two novel oral hypoglycaemic agents, NN623 and A4166.
Topics: Administration, Oral; Biological Availability; Blood Glucose; Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Glyburide; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Intestinal Absorption; Molecular Structure; Nateglinide; Phenylalanine; Piperidines; Reference Values; Stereoisomerism | 1996 |
Improved control of mealtime glucose excursions with coadministration of nateglinide and metformin.
Topics: Adult; Aged; Blood Glucose; Cyclohexanes; Diabetes Mellitus, Type 2; Drug Administration Schedule; Drug Therapy, Combination; Eating; Female; Glyburide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Male; Metformin; Middle Aged; Nateglinide; Phenylalanine; Postprandial Period | 2000 |
Importance of early insulin secretion: comparison of nateglinide and glyburide in previously diet-treated patients with type 2 diabetes.
Topics: Aged; Area Under Curve; Blood Glucose; C-Peptide; Cyclohexanes; Diabetes Mellitus, Type 2; Diet, Diabetic; Double-Blind Method; Fasting; Female; Glyburide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Male; Middle Aged; Nateglinide; Phenylalanine; Placebos; Postprandial Period; Proinsulin; Single-Blind Method; Time Factors | 2001 |
Importance of early phase insulin secretion to intravenous glucose tolerance in subjects with type 2 diabetes mellitus.
Topics: Aged; Cross-Over Studies; Cyclohexanes; Diabetes Mellitus, Type 2; Female; Glucose; Glucose Tolerance Test; Glyburide; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Male; Middle Aged; Nateglinide; Phenylalanine; Reproducibility of Results; Sodium Chloride; Time Factors | 2001 |
A placebo-controlled crossover study comparing the effects of nateglinide and glibenclamide on postprandial hyperglycaemia and hyperinsulinaemia in patients with type 2 diabetes.
Topics: Aged; Blood Glucose; C-Peptide; Cross-Over Studies; Cyclohexanes; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged; Nateglinide; Phenylalanine; Postprandial Period | 2004 |
Hypoglycemic potential of nateglinide versus glyburide in patients with type 2 diabetes mellitus.
Topics: Adult; Aged; Area Under Curve; Blood Glucose; Cyclohexanes; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Glucose Clamp Technique; Glyburide; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged; Nateglinide; Phenylalanine | 2004 |
PRESERVE-beta: two-year efficacy and safety of initial combination therapy with nateglinide or glyburide plus metformin.
Topics: Body Mass Index; Cyclohexanes; Diabetes Mellitus, Type 2; Drug Administration Schedule; Drug Therapy, Combination; Female; Glyburide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Middle Aged; Nateglinide; Phenylalanine; Placebos | 2005 |
Improved prandial glucose control with lower risk of hypoglycemia with nateglinide than with glibenclamide in patients with maturity-onset diabetes of the young type 3.
Topics: Adult; Aged; Blood Glucose; C-Peptide; Cross-Over Studies; Cyclohexanes; Diabetes Mellitus, Type 2; Double-Blind Method; Exercise Test; Female; Glucagon; Glyburide; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin; Male; Middle Aged; Nateglinide; Phenylalanine; Postprandial Period | 2006 |
Nateglinide with glibenclamide examination using the respiratory quotient (RQ).
Topics: Aged; Blood Glucose; Body Weight; Cyclohexanes; Diabetes Mellitus, Type 2; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin Resistance; Lipid Metabolism; Lipids; Male; Middle Aged; Nateglinide; Phenylalanine; Weight Gain | 2006 |
Nateglinide, alone or in combination with metformin, is effective and well tolerated in treatment-naïve elderly patients with type 2 diabetes.
Topics: Aged; Aged, 80 and over; Blood Glucose; Body Mass Index; Cyclohexanes; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Female; Glyburide; Glycated Hemoglobin; Humans; Hypoglycemia; Hypoglycemic Agents; Male; Metformin; Middle Aged; Nateglinide; Phenylalanine; Treatment Outcome | 2008 |
Effects of nateglinide and glibenclamide on prothrombotic factors in naïve type 2 diabetic patients treated with metformin: a 1-year, double-blind, randomized clinical trial.
Topics: Adult; Cyclohexanes; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Female; Glyburide; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Nateglinide; Phenylalanine; Plasminogen Activator Inhibitor 1; Tissue Plasminogen Activator | 2007 |
Nateglinide and glibenclamide metabolic effects in naïve type 2 diabetic patients treated with metformin.
Topics: Blood Glucose; Body Mass Index; Cyclohexanes; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Female; Glyburide; Glycated Hemoglobin; Hemodynamics; Homeostasis; Humans; Hypoglycemic Agents; Insulin; Lipids; Male; Metformin; Middle Aged; Nateglinide; Phenylalanine | 2009 |
Nateglinide provides tighter glycaemic control than glyburide in patients with Type 2 diabetes with prevalent postprandial hyperglycaemia.
Topics: Adult; Aged; Aged, 80 and over; Cardiovascular Diseases; Cyclohexanes; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Double-Blind Method; Fasting; Female; Glyburide; Glycated Hemoglobin; Humans; Hyperglycemia; Middle Aged; Nateglinide; Phenylalanine; Postprandial Period | 2011 |
32 other study(ies) available for phenylalanine and glyburide
| Article | Year |
|---|---|
Possibility of ideal blood glucose control by a new oral hypoglycemic agent, N-[(trans-4-isopropylcyclohexyl)-carbonyl]-D-phenylalanine (A-4166), and its stimulatory effect on insulin secretion in animals.
Topics: Animals; Blood Glucose; Cyclohexanes; Diabetes Mellitus, Experimental; Dogs; Glucose Tolerance Test; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; Male; Mice; Mice, Mutant Strains; Nateglinide; Phenylalanine; Rats; Rats, Inbred Strains; Tolbutamide | 1991 |
Effects of D-phenylalanine-derivative hypoglycemic agent A-4166 on pancreatic alpha- and beta-cells: comparative study with glibenclamide.
Topics: Analysis of Variance; Animals; Cyclohexanes; Diazoxide; Drug Interactions; Glucagon; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Nateglinide; Perfusion; Phenylalanine; Rats; Rats, Wistar | 1995 |
Stimulating activity of A-4166 on insulin release in in situ hamster pancreatic perfusion.
Topics: Animals; Blood Glucose; Cricetinae; Cyclohexanes; Diazoxide; Drug Interactions; Glyburide; Hypoglycemic Agents; Insulin; Islets of Langerhans; Male; Mesocricetus; Nateglinide; Pancreas; Perfusion; Phenylalanine; Vasodilator Agents | 1995 |
Conformational analysis of non-sulfonylurea hypoglycemic agents of the meglitinide family.
Topics: Benzamides; Carbamates; Cyclohexanes; Drug Design; Glyburide; Hypoglycemic Agents; Indoles; Isoindoles; Molecular Conformation; Nateglinide; Phenylalanine; Piperidines; Stereoisomerism; Structure-Activity Relationship; Sulfonylurea Compounds | 1995 |
Studies on the N-[(trans-4-isopropylcyclohexyl)-carbonyl]-D-phenylalanin e (A-4166)receptor in HIT T-15 cells. Displacement of [3H]glibenclamide.
Topics: Animals; Binding Sites; Cricetinae; Cyclohexanes; Dose-Response Relationship, Drug; Glyburide; Hypoglycemic Agents; Mice; Nateglinide; Phenylalanine; Radioligand Assay | 1996 |
Hypoglycaemic and insulinotropic effects of a novel oral antidiabetic agent, (-)-N-(trans-4-isopropylcyclohexanecarbonyl)-D-phenylalanine (A-4166).
Topics: Animals; Binding, Competitive; Blood Glucose; Calcium; Cell Line; Cyclohexanes; Diazoxide; Diuretics; Dogs; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Nateglinide; Phenylalanine; Rats; Rats, Wistar; Sodium Chloride Symporter Inhibitors; Stimulation, Chemical | 1997 |
Effect of a new hypoglycemic agent, A-4166 [(-)-N-(trans-4-isopropylcyclohexanecarbonyl)-D-phenylalanine], on postprandial blood glucose excursion: comparison with voglibose and glibenclamide.
Topics: Animals; Blood Glucose; Cyclohexanes; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Glucose; Glyburide; Hypoglycemic Agents; Inositol; Insulin; Male; Nateglinide; Phenylalanine; Postprandial Period; Rats; Rats, Wistar; Sucrose | 1997 |
Insulin secretion from isolated rat islets induced by the novel hypoglycemic agent A-4166, a derivative of D-phenylalanine.
Topics: Animals; ATP-Binding Cassette Transporters; Biological Availability; Calcium; Cell Line; Cyclohexanes; Diazoxide; Epinephrine; Glucose; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Male; Nateglinide; Phenylalanine; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Drug; Rubidium; Somatostatin; Stereoisomerism; Sulfonylurea Receptors; Tolbutamide | 1998 |
Interaction of N-benzoyl-D-phenylalanine and related compounds with the sulphonylurea receptor of beta-cells.
Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Calcium; Carbutamide; Cell Line, Transformed; Cricetinae; Cyclohexanes; Glyburide; Guanosine Diphosphate; Islets of Langerhans; Male; Mice; Nateglinide; Phenylalanine; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors; Tritium | 1998 |
Tissue selectivity of antidiabetic agent nateglinide: study on cardiovascular and beta-cell K(ATP) channels.
Topics: Animals; Aorta, Thoracic; Carbamates; Cardiovascular System; Coronary Vessels; Cyclohexanes; Glyburide; Heart; Hypoglycemic Agents; Islets of Langerhans; Male; Muscle, Smooth, Vascular; Nateglinide; Phenylalanine; Piperidines; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley; Swine | 1999 |
Long-term effects of glibenclamide and nateglinide upon pancreatic islet function in normal and diabetic rats.
Topics: Animals; Blood Glucose; Cyclohexanes; Diabetes Mellitus; Female; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Nateglinide; Phenylalanine; Rats; Rats, Wistar | 1999 |
Pancreatic beta-cell K(ATP) channel activity and membrane-binding studies with nateglinide: A comparison with sulfonylureas and repaglinide.
Topics: Animals; ATP-Binding Cassette Transporters; Binding, Competitive; Carbamates; Cell Membrane; Cell Separation; Cells, Cultured; Cyclohexanes; Glucose; Glyburide; Glycosyltransferases; Humans; Hypoglycemia; Hypoglycemic Agents; In Vitro Techniques; Insulin; Islets of Langerhans; KATP Channels; Kinetics; Male; Membrane Proteins; Nateglinide; Patch-Clamp Techniques; Phenylalanine; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley; Repressor Proteins; Saccharomyces cerevisiae Proteins; Sulfonylurea Compounds | 2000 |
Inhibitory effect of anti-diabetic agents on rat organic anion transporter rOAT1.
Topics: Animals; Anion Transport Proteins; Binding, Competitive; Carbon Radioisotopes; Carrier Proteins; Chlorpropamide; Cyclohexanes; Dose-Response Relationship, Drug; Female; Glyburide; Hypoglycemic Agents; Kinetics; Nateglinide; Oocytes; p-Aminohippuric Acid; Phenylalanine; Rats; RNA, Complementary; Sulfonylurea Compounds; Tolbutamide; Xenopus | 2000 |
Effect of insulinotropic agent nateglinide on Kv and Ca(2+) channels in pancreatic beta-cell.
Topics: Animals; Calcium Channels; Carbamates; Cyclohexanes; Dose-Response Relationship, Drug; Electric Stimulation; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Male; Membrane Potentials; Nateglinide; Patch-Clamp Techniques; Phenylalanine; Piperidines; Potassium Channels; Rats; Rats, Sprague-Dawley | 2001 |
The effects of mitiglinide (KAD-1229), a new anti-diabetic drug, on ATP-sensitive K+ channels and insulin secretion: comparison with the sulfonylureas and nateglinide.
Topics: Animals; ATP-Binding Cassette Transporters; Cell Line; COS Cells; Cyclohexanes; Glyburide; Hypoglycemic Agents; Indoles; Insulin; Isoindoles; Nateglinide; Patch-Clamp Techniques; Phenylalanine; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Compounds; Sulfonylurea Receptors; Tolbutamide; Transfection | 2001 |
Comparison of insulinotrophic actions of nateglinide with glibenclamide dissociated from absorption in conscious dogs.
Topics: Absorption; Animals; ATP-Binding Cassette Transporters; Blood Glucose; Cell Membrane; Cyclohexanes; Dogs; Female; Glucose Clamp Technique; Glyburide; Hypoglycemic Agents; Insulin; Intestinal Absorption; Kinetics; Male; Nateglinide; Phenylalanine; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors | 2002 |
Interaction of nateglinide with K(ATP) channel in beta-cells underlies its unique insulinotropic action.
Topics: Adenosine Triphosphate; Animals; Carbamates; Cyclohexanes; Dose-Response Relationship, Drug; Glucose; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Membrane Potentials; Nateglinide; Phenylalanine; Piperidines; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Sulfonylurea Compounds; Time Factors | 2002 |
Decreased blood glucose excursion by nateglinide ameliorated neuropathic changes in Goto-Kakizaki rats, an animal model of non-obese type 2 diabetes.
Topics: Animals; Area Under Curve; Blood Glucose; Cyclohexanes; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Glyburide; Glycated Hemoglobin; Hypoglycemic Agents; Insulin; Nateglinide; Phenylalanine; Postprandial Period; Rats; Rats, Inbred Strains; Rats, Wistar; Sciatic Nerve; Time Factors | 2002 |
Nateglinide suppresses postprandial hypertriglyceridemia in Zucker fatty rats and Goto-Kakizaki rats: comparison with voglibose and glibenclamide.
Topics: Animals; Blood Glucose; Cyclohexanes; Glyburide; Hypertriglyceridemia; Inositol; Male; Nateglinide; Phenylalanine; Postprandial Period; Rats; Rats, Wistar; Rats, Zucker; Species Specificity | 2002 |
Pharmacodynamics, insulinotropic action and hypoglycemic effect of nateglinide and glibenclamide in normal and diabetic rats.
Topics: Animals; Blood Glucose; Cyclohexanes; Diabetes Mellitus, Experimental; Female; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; Liver; Nateglinide; Pancreas; Phenylalanine; Rats; Rats, Wistar; Reference Values; Tissue Distribution | 2003 |
Role of early insulin secretion in postglucose-loading hyperglycaemia and postfat-loading hyperlipidaemia: comparing nateglinide and glibenclamide for acute effects on insulin secretion in OLETF rats.
Topics: Adipose Tissue; Animals; Blood Glucose; Cyclohexanes; Diabetes Mellitus, Type 2; Dietary Fats; Gene Expression Regulation; Glyburide; Hyperglycemia; Hyperlipidemias; Hypoglycemic Agents; Insulin; Insulin Secretion; Lipoprotein Lipase; Male; Nateglinide; Phenylalanine; Postprandial Period; Rats; Rats, Inbred OLETF; Rats, Long-Evans; RNA, Messenger; Triglycerides | 2004 |
Sulfonylurea induced beta-cell apoptosis in cultured human islets.
Topics: Adult; Aged; Apoptosis; Calcium; Carbamates; Cells, Cultured; Cyclohexanes; Dose-Response Relationship, Drug; Glyburide; Humans; Hypoglycemic Agents; Insulin; Islets of Langerhans; Middle Aged; Nateglinide; Phenylalanine; Piperidines | 2005 |
Effects of mitiglinide on glucose-induced insulin release into the portal vein and fat-induced triglyceride elevation in prediabetic and diabetic OLETF rats.
Topics: Adipose Tissue; Animals; Blood Glucose; Cyclohexanes; Diabetes Mellitus, Type 2; Glucose Tolerance Test; Glyburide; Indoles; Insulin; Insulin Secretion; Isoindoles; Lipoprotein Lipase; Male; Nateglinide; Phenylalanine; Portal Vein; Postprandial Period; Prediabetic State; Rats; Rats, Inbred OLETF; RNA, Messenger; Sulfonylurea Compounds; Triglycerides | 2006 |
Glibenclamide attenuates the antiarrhythmic effect of endotoxin with a mechanism not involving K(ATP) channels.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Blood Pressure; Carbamates; Cyclohexanes; Disease Models, Animal; Drug Interactions; Endotoxemia; Glyburide; Heart Atria; Heart Conduction System; Lipopolysaccharides; Male; Myocardial Ischemia; Nateglinide; Phenylalanine; Piperidines; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Tachycardia, Ventricular; Tetraethylammonium; Time Factors; Ventricular Fibrillation; Ventricular Premature Complexes | 2007 |
Effects of the combination of a dipeptidyl peptidase IV inhibitor and an insulin secretagogue on glucose and insulin levels in mice and rats.
Topics: Animals; Blood Glucose; Cyclohexanes; Dipeptidyl-Peptidase IV Inhibitors; Glucagon-Like Peptide 1; Glyburide; Imidazoles; Insulin; Male; Mice; Mice, Inbred C57BL; Nateglinide; Phenylalanine; Protease Inhibitors; Pyridazines; Rats; Rats, Wistar; Tosyl Compounds | 2007 |
Testing the bipartite model of the sulfonylurea receptor binding site: binding of A-, B-, and A + B-site ligands.
Topics: Amino Acid Substitution; Animals; ATP-Binding Cassette Transporters; Binding Sites; Binding, Competitive; Carbamates; Cell Line; Cyclohexanes; Dose-Response Relationship, Drug; Glyburide; Hypoglycemic Agents; KATP Channels; Ligands; Mice; Molecular Structure; Nateglinide; Phenylalanine; Piperidines; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Binding; Radioligand Assay; Rats; Receptors, Drug; Sulfonylurea Compounds; Sulfonylurea Receptors; Transfection | 2007 |
Insulin exocytosis in Goto-Kakizaki rat beta-cells subjected to long-term glinide or sulfonylurea treatment.
Topics: Animals; Blood Glucose; Cyclohexanes; Diabetes Mellitus, Experimental; Exocytosis; Glyburide; Hypoglycemic Agents; Insulin; Insulin-Secreting Cells; Islets of Langerhans; Male; Nateglinide; Phenylalanine; Rats; Rats, Wistar; SNARE Proteins; Sulfonylurea Compounds; Time Factors | 2008 |
Differential effect of sulfonylureas on production of reactive oxygen species and apoptosis in cultured pancreatic beta-cell line, MIN6.
Topics: Animals; Apoptosis; Cell Line; Cyclohexanes; Fluoresceins; Gliclazide; Glyburide; Hypoglycemic Agents; In Situ Nick-End Labeling; Insulin-Secreting Cells; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; NADPH Oxidases; Nateglinide; Phenylalanine; Protein Kinase C; Reactive Oxygen Species; Sulfonylurea Compounds | 2008 |
Change in long-spacing collagen in Descemet's membrane of diabetic Goto-Kakizaki rats and its suppression by antidiabetic agents.
Topics: Animals; Collagen; Cornea; Cyclohexanes; Descemet Membrane; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Glyburide; Hypoglycemic Agents; Immunohistochemistry; Male; Microscopy, Immunoelectron; Nateglinide; Phenylalanine; Rats; Rats, Inbred Strains; Rats, Wistar; Reference Values | 2008 |
Pharmacogenomic analysis of ATP-sensitive potassium channels coexpressing the common type 2 diabetes risk variants E23K and S1369A.
Topics: ATP-Binding Cassette Transporters; Chlorpropamide; Cyclohexanes; Diabetes Mellitus, Type 2; Gene Expression Regulation; Gliclazide; Glyburide; Haplotypes; Homozygote; Humans; Isoindoles; Nateglinide; Patch-Clamp Techniques; Phenylalanine; Polymorphism, Single Nucleotide; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Structure-Activity Relationship; Sulfonylurea Compounds; Sulfonylurea Receptors; Tolbutamide | 2012 |
Evaluating insulin secretagogues in a humanized mouse model with functional human islets.
Topics: Animals; Blood Glucose; Cyclohexanes; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Exenatide; Glucagon-Like Peptide 1; Glucose Tolerance Test; Glyburide; Humans; Incretins; Insulin; Insulin Secretion; Islets of Langerhans; Islets of Langerhans Transplantation; Male; Mice; Mice, Nude; Nateglinide; Peptides; Phenylalanine; Pyrazines; Sitagliptin Phosphate; Specific Pathogen-Free Organisms; Triazoles; Venoms | 2013 |
Biomedical Informatics Approaches to Identifying Drug-Drug Interactions: Application to Insulin Secretagogues.
Topics: Area Under Curve; Carbamates; Cyclohexanes; Databases, Factual; Diabetes Mellitus, Type 2; Drug Interactions; Glipizide; Glyburide; Humans; Hypoglycemia; Hypoglycemic Agents; Medical Informatics; Nateglinide; Pharmacoepidemiology; Phenylalanine; Piperidines; Sulfonylurea Compounds | 2017 |