Compounds > phenylalanine

phenylalanine and dihydrofolate

phenylalanine has been researched along with dihydrofolate in 5 studies

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19902 (40.00)18.7374
1990's2 (40.00)18.2507
2000's0 (0.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Appleman, JR; Blakley, RL; Delcamp, TJ; Freisheim, JH; Prendergast, NJ1
Benkovic, SJ; Chen, JT; Taira, K; Tu, CP1
Appleman, JR; Blakley, RL; Nakano, T; Spencer, HT1
Appleman, JR; Blakley, RL; Nakano, T1
Kwon, I; Zheng, S1

Other Studies

5 other study(ies) available for phenylalanine and dihydrofolate

ArticleYear
Effects of conversion of phenylalanine-31 to leucine on the function of human dihydrofolate reductase.
    Biochemistry, 1989, May-30, Volume: 28, Issue:11

    Topics: Binding Sites; Folic Acid; Humans; Kinetics; Leucine; Methotrexate; Mutation; NADP; Phenylalanine; Recombinant Proteins; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim; X-Ray Diffraction

1989
Probing the functional role of phenylalanine-31 of Escherichia coli dihydrofolate reductase by site-directed mutagenesis.
    Biochemistry, 1987, Jun-30, Volume: 26, Issue:13

    Topics: Amino Acids; Binding Sites; Deuterium; Escherichia coli; Folic Acid; Hydrogen-Ion Concentration; Kinetics; Mutation; NADP; Phenylalanine; Plasmids; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Tyrosine; Valine

1987
Critical role of phenylalanine 34 of human dihydrofolate reductase in substrate and inhibitor binding and in catalysis.
    Biochemistry, 1994, Aug-23, Volume: 33, Issue:33

    Topics: Ammonium Sulfate; Catalysis; Chemical Precipitation; Enzyme Stability; Folic Acid; Humans; Hydrogen-Ion Concentration; Kinetics; Methotrexate; Mutagenesis, Site-Directed; NADP; Phenylalanine; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase

1994
Methotrexate-insensitive mutants of human dihydrofolate reductase (hDHFR) constructed by site-directed mutagenesis at phenylalanine 34.
    Advances in experimental medicine and biology, 1993, Volume: 338

    Topics: Amino Acid Sequence; Cloning, Molecular; Drug Resistance; Escherichia coli; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Methotrexate; Mutagenesis, Site-Directed; Phenylalanine; Recombinant Proteins; Tetrahydrofolate Dehydrogenase

1993
Controlling enzyme inhibition using an expanded set of genetically encoded amino acids.
    Biotechnology and bioengineering, 2013, Volume: 110, Issue:9

    Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Computer Simulation; Escherichia coli; Folic Acid; Folic Acid Antagonists; Methotrexate; Mice; Models, Molecular; Molecular Sequence Data; Naphthalenes; Phenylalanine; Protein Binding; Protein Engineering; Recombinant Proteins; Sequence Alignment; Tetrahydrofolate Dehydrogenase; Tryptophan

2013