Compounds > phenylalanine

phenylalanine and dextromethorphan

phenylalanine has been researched along with dextromethorphan in 4 studies

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chowdry, J; Ellis, SW; Gross, E; Harlow, J; Hayhurst, GP; Hilton, E; Lennard, MS; Tucker, GT1
Flanagan, JU; Kemp, CA; Maréchal, JD; McLaughlin, LA; Paine, MJ; Roberts, GC; Sutcliffe, MJ; Ward, R; Wolf, CR1
Commandeur, JN; de Graaf, C; Keizers, PH; Lussenburg, BM; Mentink, LM; Vermeulen, NP1
Commandeur, JN; Damsten, MC; Maasdijk, DM; van Vugt-Lussenburg, BM; Vermeulen, NP1

Other Studies

4 other study(ies) available for phenylalanine and dextromethorphan

ArticleYear
Influence of phenylalanine-481 substitutions on the catalytic activity of cytochrome P450 2D6.
    The Biochemical journal, 2001, Apr-15, Volume: 355, Issue:Pt 2

    Topics: Alkylation; Catalysis; Cytochrome P-450 CYP2D6; Debrisoquin; Dextromethorphan; Kinetics; Metoprolol; Mutagenesis, Site-Directed; Oxidation-Reduction; Phenylalanine; Substrate Specificity

2001
Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite.
    The Biochemical journal, 2004, Jun-01, Volume: 380, Issue:Pt 2

    Topics: Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Dextromethorphan; Humans; Isoenzymes; Kinetics; Mixed Function Oxygenases; Models, Biological; Mutagenesis, Site-Directed; Mutation; Nuclear Magnetic Resonance, Biomolecular; Phenylalanine; Substrate Specificity

2004
Influence of phenylalanine 120 on cytochrome P450 2D6 catalytic selectivity and regiospecificity: crucial role in 7-methoxy-4-(aminomethyl)-coumarin metabolism.
    Biochemical pharmacology, 2004, Dec-01, Volume: 68, Issue:11

    Topics: Alanine; Coumarins; Cytochrome P-450 CYP2D6; Dextromethorphan; Humans; Models, Biological; Models, Molecular; Mutagenesis; N-Methyl-3,4-methylenedioxyamphetamine; Phenylalanine

2004
Heterotropic and homotropic cooperativity by a drug-metabolising mutant of cytochrome P450 BM3.
    Biochemical and biophysical research communications, 2006, Aug-04, Volume: 346, Issue:3

    Topics: Acetaminophen; Amodiaquine; Arginine; Benzoflavones; Caffeine; Cytochrome P-450 Enzyme System; Dextromethorphan; Enzyme Activation; Humans; Kinetics; Leucine; Molecular Structure; Mutation; N-Methyl-3,4-methylenedioxyamphetamine; Pharmaceutical Preparations; Phenylalanine; Substrate Specificity

2006