phenylalanine has been researched along with boron in 80 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (1.25) | 18.7374 |
1990's | 21 (26.25) | 18.2507 |
2000's | 36 (45.00) | 29.6817 |
2010's | 13 (16.25) | 24.3611 |
2020's | 9 (11.25) | 2.80 |
Authors | Studies |
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Hori, Y; Ichihashi, M; Komura, A; Mishima, Y; Shiono, M; Yamamura, K; Yoshino, K | 1 |
Mishima, Y | 1 |
Coderre, J; Fairchild, R; Hansrote, J; Packer, S; Perry, H; Saraf, S | 1 |
Hatta, S; Honda, C; Ichihashi, M; Mishima, Y | 1 |
Coderre, JA; Glass, JD; Greenberg, D; Micca, P; Packer, S | 1 |
Barth, RF; Fairchild, RG; Soloway, AH | 1 |
Ichihashi, M; Mishima, Y; Tsuji, M | 1 |
Bywaters, A; Coderre, JA; Hopewell, JW; Liu, HB; Micca, PL; Morris, GM; Nawrocky, MM | 1 |
Allen, BJ; Halliday, GM; Harding, AJ; Moore, DE; Setiawan, Y | 1 |
Honda, C; Ichihashi, M; Mishima, Y; Wadabayashi, N | 1 |
Bennett, BD; Coderre, JA; Morrison, GH; Mumford-Zisk, J | 1 |
Coderre, JA; Hopewell, JW; Micca, PL; Morris, GM; Rezvani, M | 1 |
Feinendegen, LE; Müller-Gärtner, HW; Papaspyrou, M | 1 |
Allen, BJ; Jones, R; Mallesch, JL; McCarthy, WH; Moore, DE; Stening, WA | 1 |
Bailey, MQ; Barth, RF; Coderre, JA; Matalka, KZ; Moeschberger, ML; Rofstad, EK; Soloway, AH; Staubus, AE | 1 |
Capala, J; Coderre, JA; Makar, MS | 1 |
Hiratsuka, J; Honda, C; Ido, T; Imahori, Y; Mishima, Y; Ueda, S | 1 |
Chadha, M; Chanana, AD; Coderre, JA; Elowitz, EH; Gebbers, JO; Joel, DD; Micca, PL; Nawrocky, MM; Peress, NS; Shady, M; Slatkin, DN | 1 |
Akaboshi, M; Kinashi, Y; Kobayashi, T; Masunaga, S; Ono, K; Sakurai, Y; Suzuki, M; Takagaki, M | 1 |
Capala, J; Chadha, M; Chanana, AD; Coderre, JA; Elowitz, EH; Iwai, J; Joel, DD; Liu, HB; Wielopolski, L | 1 |
Fujii, R; Ido, T; Imahori, Y; Kobayashi, T; Kusuki, T; Ohmori, Y; Ono, K; Sakae, K; Takagaki, M; Ueda, S | 2 |
Hiratsuka, J; Imajo, Y; Kondoh, H; Mishima, Y; Yoshino, K | 1 |
Coderre, JA; Hoch, DA; Kalef-Ezra, JA; Lombardo, DT; Ma, R; Micca, PL; Miura, M; Morris, GM; Slatkin, DN; Youngs, KM | 1 |
Busse, PM; Kiger, WS; Palmer, MR; Riley, KJ; Zamenhof, RG | 1 |
Cassapo, R; Castro, M; Chaveca, T; Fernandes, AP; Gonçalves, IC; Oliveira, NG; Rodrigues, AS; Rueff, J; Toscano-Rico, JM | 1 |
Färkkilä, M; Kallio, M; Kulvik, M; Laakso, J; Ruokonen, I; Vähätalo, J; Zilliacus, R | 1 |
Barth, RF; Chandra, S; Coderre, JA; Joel, DD; Smith, DR; Yang, W | 1 |
Batistoni, D; Dagrosa, A; Farías, S; Garavaglia, R; Itoiz, ME; Kreimann, EL; Schwint, AE | 1 |
Ehara, K; Hiratsuka, J; Iwakura, M; Kondoh, H; Mishima, Y; Tamaki, N | 1 |
Agote, M; Cabrini, RL; Dadino, JL; Dagrosa, MA; Farías, S; Garavaglia, R; Juvenal, GJ; Kreimann, E; Pisarev, MA; Viaggi, M | 1 |
Coderre, J; Diaz, AZ; Hiismäki, P; Kallio, M; Kangasmäki, A; Kulvik, M; Laakso, J; Ryynänen, P; Savolainen, S | 1 |
Chandra, S; Lorey II, DR; Smith, DR | 1 |
Chandra, S; Coderre, JA; Kabalka, GW; Lorey, DR; Smith, DR | 1 |
Matsumura, A; Nakauchi, H; Nose, T; Okumura, M; Shibata, Y; Yamamoto, T; Yoshida, F | 1 |
Moreno, DA; Romero, L; Ruiz, JM; Víllora, G | 1 |
Braun, I; Braun, K; Corban-Wilhelm, H; Debus, J; Ehemann, V; Eisenmenger, A; Heckl, S; Jenne, J; Pipkorn, R; Rastert, R; Waldeck, W; Wolber, G | 1 |
DeRose, EF; Gabel, SA; Krahn, JM; London, RE; Transue, TR | 1 |
Kato, I; Masunaga, S; Nagata, K; Obayashi, S; Ono, K; Sakurai, Y; Suzuki, M; Yura, Y | 1 |
Capala, J; Dahlström, M; Lindström, A; Lindström, P; Wasteson, A | 1 |
Filippov, VI; Komissarova, LKh; Kuznetsov, AA; Kuznetsov, OA; Podoynitsyn, SN | 1 |
Basilico, F; Mauri, PL; Moss, R; Pozzi, F; Sauerwein, W; Wittig, A | 1 |
Asano, T; Hattori, Y; Kirihata, M; Kondoh, H; Niki, Y; Wakamiya, T; Yamaguchi, Y | 1 |
Batistoni, DA; Gautier, EA; Gettar, RT; Jiménez Rebagliati, R; Roberti, MJ | 1 |
Asano, T; Hattori, Y; Kirihata, M; Kondoh, H; Kurihara, K; Wakamiya, T; Yamaguchi, Y | 1 |
Blaumann, H; Calzetta, O; Cantarelli, MA; Heber, EM; Itoiz, ME; Longhino, J; Nigg, DW; Rao, M; Schwint, AE; Trivillin, VA | 1 |
Shibata, Y | 1 |
Barth, RF; Chandra, S; Lorey, DR; Tjarks, W | 1 |
Bergenheim, AT; Blomquist, E; Capala, J; Franzén, L; Henriksson, R; Lindahl, SA; Michanek, A; Salford, LG; Westlin, JE | 1 |
Nakamura, H | 1 |
H-Stenstam, B | 1 |
Albritton, JR; Auterinen, I; Binns, PJ; Harling, OK; Kiger, WS; Marek, M; Moss, RL; Nievaart, VA; Rezaei, A; Riley, KJ; Savolainen, S; Seppälä, T; Sköld, K; Viererbl, L | 1 |
Chi, CW; Chou, FI; Chung, HP; Liu, HM; Lui, WY | 1 |
Inaji, M; Ishii, K; Ishiwata, K; Kimura, Y; Matsumura, A; Momose, T; Nariai, T; Ohno, K; Yamamoto, T | 1 |
Bumaschny, E; Cardoso, J; Heber, E; Itoiz, M; Liberman, S; Monti Hughes, A; Nievas, S; Pereira, M; Pozzi, E; Sanchez, P; Schwint, A; Trivillin, V | 1 |
Fujimoto, T; Fukumori, Y; Ichikawa, H; Taniguchi, E | 1 |
Altieri, S; Cionini, L; Menichetti, L; Minn, H; Salvadori, PA; Sauerwein, WA; Solin, O | 1 |
Bet, P; Hilken, G; Huiskamp, R; Kriegeskotte, C; Moss, RL; Sauerwein, WA; Scherag, A; Wittig, A | 1 |
Altieri, S; Bakeine, JG; Ballarini, F; Bortolussi, S; Bruschi, P; Cansolino, L; Clerici, A; Ferrari, C; Gadan, MA; Nano, R; Protti, N; Stella, S; Zonta, A; Zonta, C | 1 |
García-Reiriz, A; Líberman, S; Magallanes, J; Zupan, J | 1 |
Cabrini, RL; Carpano, M; Dagrosa, A; Portu, A; Saint Martin, G | 1 |
Hattori, T; Ishikawa, A; Ohki, H; Saito, K; Yabe, T; Yoshino, K | 1 |
Ahmad, T; Barth, RF; Chandra, S; Kabalka, GW | 1 |
Bernocchi, G; Coccini, T; Nion, S; Roda, E | 1 |
Canella, L; Kudejova, P; Röhrmoser, A; Schmid, E; Schmid, TE; Wagner, FM | 1 |
Hagiwara, K; Hamase, K; Kanai, Y; Kato, I; Miyoshi, Y; Nagamori, S; Ohgaki, R; Wei, L; Wiriyasermkul, P; Wongthai, P | 1 |
Hattori, Y; Ishimura, M; Kirihata, M; Ohta, Y; Ono, K; Takenaka, H; Tanaka, H; Watanabe, T | 1 |
Brandizzi, D; Cabrini, R; Carpano, M; Dagrosa, MA; Juvenal, GJ; Nievas, S; Olivera, M; Perona, M; Pisarev, M; Rodriguez, C; Santa Cruz, GA | 1 |
Hermans, R; Jääskeläinen, J; Järviluoma, E; Kallio, M; Kulvik, M; Laakso, J; Paetau, A; Rasilainen, M; Ruokonen, I; Seppälä, M; Vähätalo, J | 1 |
Ai, HW; Borchardt, D; Chen, ZJ; Ji, A; Jiang, DE; Kallio, K; Oleson, AL; Remington, SJ; Tian, Z | 1 |
Hatazawa, J; Horitsugi, G; Isohashi, K; Naka, S; Shimosegawa, E | 1 |
Date, H; Fukunaga, H; Matsuya, Y; Omura, M | 1 |
Fukuda, H; Hiratsuka, J | 1 |
Dousti, F; Hassanzadeh, F; Kasesaz, Y; Mirian, M; Rostami, M; Soleimanbeigi, M; Varshosaz, J | 1 |
Fukuo, Y; Futamura, G; Hiramatsu, R; Hu, N; Kashiwagi, H; Kawabata, S; Miyatake, SI; Suzuki, M; Takata, T; Takeuchi, K; Tanaka, H; Wanibuchi, M; Watanabe, T; Yoshimura, K | 1 |
Chen, YW; Chou, FI; Lee, YJ; Lin, YC; Wang, SY | 1 |
Aoki, E; Kondo, N; Takada, S; Temma, T | 1 |
Capo, L; Carroll, R; Dlamini, S; Ikeura, M; Jahanshir, E; Kang, S; Kulenovic, L; Malinao, MC; Martin, T; Morrison, K; Quintana, JC; Raitano, A; Torgov, M; Zhang, C | 1 |
Balcer, E; Bulska, E; Giebułtowicz, J; Muszyńska, M; Ruszczyńska, A; Sochacka, M | 1 |
Hirano, F; Kondo, N; Murata, Y; Sudani, A; Temma, T | 1 |
3 review(s) available for phenylalanine and boron
Article | Year |
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A post melanosomal era: control of melanogenesis and melanoma growth.
Topics: Adolescent; Animals; Boron; Boron Compounds; Cricetinae; Fatty Acids, Unsaturated; Gene Expression Regulation, Neoplastic; Hair Color; Humans; Infant, Newborn; Isotopes; Male; Melanins; Melanocytes; Melanoma; Melanoma, Experimental; Models, Biological; Monophenol Monooxygenase; Neoplasm Proteins; Neutrons; Phenylalanine; Pigmentation Disorders; Protein Processing, Post-Translational; Pyrones; Radiation-Sensitizing Agents; Skin Pigmentation; Subcellular Fractions; Swine | 1992 |
[Boron delivery system for neutron capture therapy of cancer].
Topics: Animals; Boron; Boron Compounds; Boron Neutron Capture Therapy; Drug Delivery Systems; Humans; Liposomes; Neoplasms; Phenylalanine; Positron-Emission Tomography | 2008 |
Pharmacokinetics of
Topics: Boron; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Glioblastoma; Humans; Isotopes; Melanoma; Neoplasms; Phenylalanine; Positron-Emission Tomography | 2020 |
6 trial(s) available for phenylalanine and boron
Article | Year |
---|---|
Boron neutron-capture therapy (BNCT) for glioblastoma multiforme (GBM) using the epithermal neutron beam at the Brookhaven National Laboratory.
Topics: Aged; Boron; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Dose-Response Relationship, Radiation; Feasibility Studies; Glioblastoma; Humans; Middle Aged; Phenylalanine; Radiation-Sensitizing Agents; Radiotherapy Dosage; Treatment Outcome | 1998 |
A pharmacokinetic model for the concentration of 10B in blood after boronophenylalanine-fructose administration in humans.
Topics: Adult; Aged; Boron; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Female; Fructose; Glioblastoma; Humans; Infusions, Intravenous; Male; Melanoma; Middle Aged; Models, Biological; Phenylalanine; Skin Neoplasms | 2001 |
Atomic emission method for total boron in blood during neutron-capture therapy.
Topics: Adult; Aged; Boron; Boron Compounds; Boron Neutron Capture Therapy; Female; Hematocrit; Humans; Indicators and Reagents; Male; Mass Spectrometry; Middle Aged; Phenylalanine; Sensitivity and Specificity; Spectrophotometry, Atomic | 2001 |
Boron neutron capture therapy (BNCT) for glioblastoma multiforme: a phase II study evaluating a prolonged high-dose of boronophenylalanine (BPA).
Topics: Adult; Aged; Boron; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Female; Fructose; Glioblastoma; Humans; Male; Middle Aged; Phenylalanine; Quality of Life; Survival Rate; Treatment Outcome | 2008 |
Boron biodistribution study in colorectal liver metastases patients in Argentina.
Topics: Adenocarcinoma; Aged; Argentina; Boron; Boron Compounds; Boron Neutron Capture Therapy; Colorectal Neoplasms; Female; Humans; In Vitro Techniques; Infusions, Intravenous; Isotopes; Liver; Liver Neoplasms; Liver Transplantation; Male; Middle Aged; Phenylalanine; Radiation-Sensitizing Agents; Tissue Distribution; Transplantation, Autologous | 2009 |
Assessment of
Topics: Adult; Boron; Boron Compounds; Boron Neutron Capture Therapy; Female; Healthy Volunteers; Humans; Isotopes; Male; Middle Aged; Phenylalanine; Positron-Emission Tomography; Radiotherapy Dosage; Radiotherapy, Image-Guided; Tissue Distribution; Young Adult | 2016 |
71 other study(ies) available for phenylalanine and boron
Article | Year |
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In vitro radiobiological analysis of 10B-L-BPA for BNCT of malignant melanoma: correlation of determined 10B-content and cell killing effect.
Topics: Animals; Boron; Boron Compounds; Dose-Response Relationship, Radiation; Fibroblasts; Humans; Isotopes; Mass Spectrometry; Melanoma, Experimental; Mice; Neutrons; Phenylalanine; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 1992 |
Boron neutron capture therapy of anterior chamber melanoma with p-boronophenylalanine.
Topics: Administration, Oral; Animals; Anterior Chamber; Autoradiography; Boron; Boron Compounds; Disease Models, Animal; Eye Neoplasms; Isotopes; Melanoma, Experimental; Neutrons; Phenylalanine; Rabbits; Radiation-Sensitizing Agents | 1992 |
In situ detection of cutaneous melanoma by prompt gamma-ray spectrometry using melanoma-seeking 10B-dopa analogue.
Topics: Aged; Animals; Boron; Boron Compounds; Cricetinae; Disease Models, Animal; Female; Humans; Isotopes; Male; Melanoma; Mesocricetus; Phenylalanine; Skin Neoplasms; Spectrometry, Gamma; Time Factors | 1990 |
Experimental boron neutron capture therapy for melanoma: systemic delivery of boron to melanotic and amelanotic melanoma.
Topics: Animals; Boron; Boron Compounds; Eye Neoplasms; Isotopes; Lung Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Neutrons; Phenylalanine; Rabbits; Radiation-Sensitizing Agents; Transplantation, Heterologous | 1990 |
Boron neutron capture therapy for cancer.
Topics: Alpha Particles; Animals; Antibodies, Monoclonal; Boron; Boron Compounds; Brain Neoplasms; Glioblastoma; Humans; Immunotoxins; Isotopes; Melanoma; Mice; Neoplasms; Neutrons; Phenylalanine; Radiation Dosage | 1990 |
[Selective affinity of 10B1-paraboronophenylalanine-HCl to malignant melanoma: thermal neutron capture therapy].
Topics: Animals; Boron; Boron Compounds; Cricetinae; Isotopes; Melanoma; Neoplasms, Experimental; Neutrons; Phenylalanine; Skin; Skin Neoplasms; Spectrometry, Gamma | 1983 |
Response of the central nervous system to boron neutron capture irradiation: evaluation using rat spinal cord model.
Topics: Absorption; Animals; Blood-Brain Barrier; Borohydrides; Boron; Boron Compounds; Boron Neutron Capture Therapy; Disease Models, Animal; Dose-Response Relationship, Radiation; Isotopes; Linear Energy Transfer; Male; Phenylalanine; Radiation-Sensitizing Agents; Radiotherapy Dosage; Rats; Rats, Inbred F344; Relative Biological Effectiveness; Spinal Cord; Spinal Cord Diseases; Sulfhydryl Compounds | 1994 |
Effect of L-10B-p-boronophenylalanine-fructose and the boron neutron capture reaction on mouse brain dopaminergic neurons.
Topics: Animals; Blood-Brain Barrier; Boron; Boron Compounds; Boron Neutron Capture Therapy; Brain; Dopamine; Fructose; Immunohistochemistry; Isotopes; Male; Mice; Mice, Inbred BALB C; Nerve Fibers; Neurons; Phenylalanine; Radiation-Sensitizing Agents | 1995 |
Selective boron accumulation in human ocular melanoma vs surrounding eye components after 10B1-p-boronophenylalanine administration. Prerequisite for clinical trial of neutron-capture therapy.
Topics: Boron; Boron Compounds; Clinical Trials as Topic; Eye Neoplasms; Humans; Isotopes; Mass Spectrometry; Melanoma; Neutron Capture Therapy; Phenylalanine; Radiation-Sensitizing Agents | 1994 |
Subcellular localization of p-boronophenylalanine-delivered boron-10 in the rat 9L gliosarcoma: cryogenic preparation in vitro and in vivo.
Topics: Animals; Boron; Boron Compounds; Boron Neutron Capture Therapy; Gliosarcoma; Isotopes; Phenylalanine; Rats; Tumor Cells, Cultured | 1994 |
Response of rat skin to boron neutron capture therapy with p-boronophenylalanine or borocaptate sodium.
Topics: Administration, Oral; Animals; Borohydrides; Boron; Boron Compounds; Boron Neutron Capture Therapy; Dose-Response Relationship, Radiation; Endothelium, Vascular; Injections, Intravenous; Isotopes; Male; Phenylalanine; Radiation Dosage; Radiation Injuries, Experimental; Radiation-Sensitizing Agents; Rats; Rats, Inbred F344; Relative Biological Effectiveness; Skin; Skin Diseases; Spectrometry, Gamma; Sulfhydryl Compounds; Wound Healing | 1994 |
Preloading with L-tyrosine increases the uptake of boronophenylalanine in mouse melanoma cells.
Topics: Animals; Boron; Boron Compounds; Boron Neutron Capture Therapy; Melanoma; Mice; Phenylalanine; Radiation-Sensitizing Agents; Time Factors; Tumor Cells, Cultured; Tyrosine | 1994 |
The pharmacokinetics of p-Boronophenylalanine.fructose in human patients with glioma and metastatic melanoma.
Topics: Boron; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Glioma; Humans; Melanoma; Phenylalanine; Radiation-Sensitizing Agents | 1994 |
Boron neutron capture therapy of intracerebral melanoma using boronophenylalanine as a capture agent.
Topics: Animals; Boron; Boron Compounds; Boron Neutron Capture Therapy; Brain; Brain Neoplasms; Cell Survival; Humans; Male; Melanoma; Middle Aged; Phenylalanine; Radiation-Sensitizing Agents; Radiotherapy Dosage; Rats; Rats, Nude; Tissue Distribution | 1993 |
Accumulation of boron in malignant and normal cells incubated in vitro with boronophenylalanine, mercaptoborane or boric acid.
Topics: Animals; Boric Acids; Boron; Boron Compounds; Boron Neutron Capture Therapy; Humans; Mice; Phenylalanine; Tumor Cells, Cultured | 1996 |
In vivo diagnosis of human malignant melanoma with positron emission tomography using specific melanoma-seeking 18F-DOPA analogue.
Topics: Boron; Boron Compounds; Brain; Brain Neoplasms; Fluorine Radioisotopes; Humans; Isotopes; Lymphatic Metastasis; Melanoma; Phenylalanine; Tomography, Emission-Computed | 1997 |
Biodistribution of boronophenylalanine in patients with glioblastoma multiforme: boron concentration correlates with tumor cellularity.
Topics: Boron; Boron Compounds; Boron Neutron Capture Therapy; Glioblastoma; Humans; Phenylalanine; Tissue Distribution | 1998 |
Responses of total and quiescent cell populations in solid tumors to boron and gadolinium neutron capture reaction using neutrons with two different energy spectra.
Topics: Animals; Borohydrides; Boron; Boron Compounds; Boron Neutron Capture Therapy; Bromodeoxyuridine; Cadmium Radioisotopes; Carcinoma, Squamous Cell; Contrast Media; Cytochalasin B; Dose-Response Relationship, Radiation; Female; Fluorescent Antibody Technique, Indirect; Gadolinium; Gadolinium DTPA; Injections, Intraperitoneal; Isotopes; Mice; Mice, Inbred C3H; Micronucleus Tests; Neoplasm Transplantation; Phenylalanine; Radiation-Sensitizing Agents; Sulfhydryl Compounds; Tumor Cells, Cultured | 1998 |
Positron emission tomography-based boron neutron capture therapy using boronophenylalanine for high-grade gliomas: part I.
Topics: Boron; Boron Compounds; Boron Neutron Capture Therapy; Fluorine Radioisotopes; Glioma; Humans; Isotopes; Phenylalanine; Radiation-Sensitizing Agents; Tomography, Emission-Computed | 1998 |
Positron emission tomography-based boron neutron capture therapy using boronophenylalanine for high-grade gliomas: part II.
Topics: Boron; Boron Compounds; Boron Neutron Capture Therapy; Fluorine Radioisotopes; Glioma; Humans; Isotopes; Mathematical Computing; Phenylalanine; Radiation-Sensitizing Agents; Tomography, Emission-Computed | 1998 |
Biodistribution of boron concentration on melanoma-bearing hamsters after administration of p-, m-, o-boronophenylalanine.
Topics: Animals; Boron; Boron Compounds; Boron Neutron Capture Therapy; Cricetinae; Male; Melanins; Melanoma, Experimental; Mesocricetus; Mice; Phenylalanine; Radiation-Sensitizing Agents; Tissue Distribution | 2000 |
Boron neutron capture therapy of a murine mammary carcinoma using a lipophilic carboranyltetraphenylporphyrin.
Topics: Animals; Borohydrides; Boron; Boron Compounds; Boron Neutron Capture Therapy; Drug Carriers; Female; Hindlimb; Hydrophobic and Hydrophilic Interactions; Injections, Intraperitoneal; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Phenylalanine; Sulfhydryl Compounds; Thorax; Tissue Distribution | 2001 |
Evaluation of the genotoxic effects of the boron neutron capture reaction in human melanoma cells using the cytokinesis block micronucleus assay.
Topics: Animals; Boron; Boron Compounds; Boron Neutron Capture Therapy; Cell Division; Cell Line; Cells, Cultured; Cricetinae; Drug Carriers; Fast Neutrons; Humans; Isotopes; Melanoma; Micronucleus Tests; Phenylalanine; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 2001 |
Quantitative imaging and microlocalization of boron-10 in brain tumors and infiltrating tumor cells by SIMS ion microscopy: relevance to neutron capture therapy.
Topics: Animals; Boron; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Drug Administration Schedule; Gliosarcoma; Infusions, Intravenous; Isotopes; Male; Phenylalanine; Rats; Rats, Inbred F344; Spectrometry, Mass, Secondary Ion | 2001 |
The hamster cheek pouch as a model of oral cancer for boron neutron capture therapy studies: selective delivery of boron by boronophenylalanine.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Boron; Boron Compounds; Boron Neutron Capture Therapy; Carcinogens; Cheek; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Injections, Intravenous; Injections, Subcutaneous; Mesocricetus; Mouth Neoplasms; Phenylalanine; Radiation-Sensitizing Agents; Tissue Distribution | 2001 |
Effect of boron neutron capture therapy for melanotic and amelanotic melanoma transplanted into mouse brain.
Topics: Animals; Boron; Boron Compounds; Boron Neutron Capture Therapy; Brain; Brain Neoplasms; Isotopes; Melanins; Melanoma, Amelanotic; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Phenylalanine; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 2002 |
Selective uptake of p-borophenylalanine by undifferentiated thyroid carcinoma for boron neutron capture therapy.
Topics: Adenoma; Animals; Boron; Boron Compounds; Boron Neutron Capture Therapy; Cattle; Cell Division; Cells, Cultured; Humans; Isotopes; Kinetics; Mice; Mice, Nude; Neoplasm Transplantation; Phenylalanine; Radiation-Sensitizing Agents; Thyroid Gland; Thyroid Neoplasms; Tumor Cells, Cultured | 2002 |
Non-linear model for the kinetics of 10B in blood after BPA-fructose complex infusion.
Topics: Boron; Boron Compounds; Fructose; Humans; Isotopes; Kinetics; Models, Statistical; Models, Theoretical; Phenylalanine; Radiometry; Time Factors; Tomography, Emission-Computed | 2002 |
Quantitative subcellular secondary ion mass spectrometry (SIMS) imaging of boron-10 and boron-11 isotopes in the same cell delivered by two combined BNCT drugs: in vitro studies on human glioblastoma T98G cells.
Topics: Borohydrides; Boron; Boron Compounds; Boron Neutron Capture Therapy; Cell Division; Cell Size; Glioblastoma; Humans; Organelles; Phenylalanine; Radioisotopes; Spectrometry, Mass, Secondary Ion; Sulfhydryl Compounds; Time Factors; Tumor Cells, Cultured | 2002 |
Imaging of fluorine and boron from fluorinated boronophenylalanine in the same cell at organelle resolution by correlative ion microscopy and confocal laser scanning microscopy.
Topics: Boron; Boron Compounds; Brain Neoplasms; Fluorine; Glioblastoma; Humans; Image Processing, Computer-Assisted; Ions; Microscopy, Confocal; Mitochondria; Models, Chemical; Phenylalanine; Radiation-Sensitizing Agents; Time Factors; Tomography, Emission-Computed; Tumor Cells, Cultured | 2002 |
Cell cycle dependence of boron uptake from two boron compounds used for clinical neutron capture therapy.
Topics: Animals; Borohydrides; Boron; Boron Compounds; Boron Neutron Capture Therapy; Cell Cycle; Cricetinae; Flow Cytometry; Mice; Phenylalanine; Rats; Spectrophotometry, Atomic; Sulfhydryl Compounds; Tumor Cells, Cultured | 2002 |
Growth conditions, elemental accumulation and induced physiological changes in Chinese cabbage.
Topics: Agriculture; Aluminum; Anthocyanins; Boron; Brassica; Calcium; Catechol Oxidase; Pectins; Phenols; Phenylalanine; Silicon; Silver; Soil; Soil Pollutants; Trace Elements; Tyrosine; Water | 2003 |
The enhancement of neutron irradiation of HeLa-S cervix carcinoma cells by cell-nucleus-addressed deca-p-boronophenylalanine.
Topics: Active Transport, Cell Nucleus; Amino Acid Sequence; Boron; Boron Compounds; Boron Neutron Capture Therapy; Carcinoma; Cell Nucleus; Cell Survival; Female; Flow Cytometry; HeLa Cells; Humans; Mass Spectrometry; Microscopy, Confocal; Molecular Sequence Data; Phenylalanine; Radiation-Sensitizing Agents; Uterine Cervical Neoplasms | 2003 |
X-ray and NMR characterization of covalent complexes of trypsin, borate, and alcohols.
Topics: Amino Alcohols; Animals; Binding Sites; Borates; Boron; Crystallization; Crystallography, X-Ray; Macromolecular Substances; Nuclear Magnetic Resonance, Biomolecular; Pancreas; Phenylalanine; Protein Conformation; Protons; Solutions; Substrate Specificity; Swine; Trypsin | 2004 |
Delivery of (10)boron to oral squamous cell carcinoma using boronophenylalanine and borocaptate sodium for boron neutron capture therapy.
Topics: Animals; Borohydrides; Boron; Boron Compounds; Boron Neutron Capture Therapy; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Survival; Female; Isotopes; Mice; Mice, Nude; Mouth Neoplasms; Phenylalanine; Relative Biological Effectiveness; Sulfhydryl Compounds | 2004 |
Accumulation of boron in human malignant glioma cells in vitro is cell type dependent.
Topics: Boranes; Boron; Boron Neutron Capture Therapy; Brain Neoplasms; Cell Line; Cell Line, Tumor; Fibroblasts; Glioblastoma; Glioma; Humans; Phenylalanine | 2004 |
Approach to magnetic neutron capture therapy.
Topics: Boron; Boron Compounds; Carbon; Drug Carriers; Iron; Magnetics; Nanotechnology; Neutron Capture Therapy; Phenylalanine | 2005 |
Analysis of 10B antitumoral compounds by means of flow-injection into ESI-MS/MS.
Topics: Adult; Borohydrides; Boron; Boron Compounds; Boron Neutron Capture Therapy; Clinical Trials, Phase I as Topic; Humans; Isotopes; Middle Aged; Phenylalanine; Spectrometry, Mass, Electrospray Ionization; Sulfhydryl Compounds | 2005 |
Study on the compounds containing 19F and 10B atoms in a single molecule for the application to MRI and BNCT.
Topics: Animals; Boron; Boron Neutron Capture Therapy; Boronic Acids; Cell Line, Tumor; Cells, Cultured; Contrast Media; Fluorine; HeLa Cells; Humans; Isotopes; Magnetic Resonance Imaging; Molecular Structure; Neoplasms; Phenylalanine; Rats | 2006 |
Assessment of chemical purity of 10B-enriched p-boronophenylalanine by high-performance liquid chromatography coupled on-line with inductively coupled plasma optical emission spectrometry.
Topics: Boron; Boron Compounds; Buffers; Chromatography, High Pressure Liquid; Drug Stability; Hydrogen-Ion Concentration; Phenylalanine; Radiation-Sensitizing Agents; Spectrophotometry; Spectrophotometry, Ultraviolet; Tyrosine | 2007 |
Biological evaluation of fluorinated p-boronophenylalanine derivatives as a boron carrier.
Topics: Animals; Antineoplastic Agents; Boron; Boron Compounds; Cell Survival; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor; Glioma; Hydrocarbons, Fluorinated; Ion Transport; Models, Biological; Phenylalanine; Rats; Solubility; Tumor Cells, Cultured | 2007 |
Boron neutron capture therapy (BNCT) for the treatment of spontaneous nasal planum squamous cell carcinoma in felines.
Topics: Animals; Boron; Boron Neutron Capture Therapy; Carcinoma, Squamous Cell; Cat Diseases; Cats; Dose-Response Relationship, Radiation; Female; Isotopes; Male; Neoplasm Staging; Neutrons; Nose; Nose Neoplasms; Phenylalanine; Treatment Outcome | 2008 |
Boron distribution in the normal rat brain after intravenous injection of boronophenylalanine-fructose.
Topics: Animals; Autoradiography; Boron; Boron Compounds; Boron Neutron Capture Therapy; Brain Chemistry; Fructose; Injections, Intravenous; Male; Phenylalanine; Rats; Rats, Inbred F344 | 2008 |
Quantitative subcellular imaging of boron compounds in individual mitotic and interphase human glioblastoma cells with imaging secondary ion mass spectrometry (SIMS).
Topics: Boron; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Cell Line; Glioblastoma; Humans; Interphase; Mitosis; Phenylalanine; Spectrometry, Mass, Secondary Ion | 2008 |
Comments to article: Henriksson R et al., Boron neutron capture therapy (BNCT) for glioblastoma multiforme: a phase II study evaluating a prolonged high-dose of boronophenylalanine (BPA) Radiother Oncol (2008).
Topics: Adult; Aged; Boron; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Clinical Trials, Phase II as Topic; Female; Fructose; Glioblastoma; Humans; Male; Middle Aged; Phenylalanine; Quality of Life; Survival Rate; Treatment Outcome | 2008 |
An international dosimetry exchange for BNCT part II: computational dosimetry normalizations.
Topics: Boron; Boron Compounds; Boron Neutron Capture Therapy; Clinical Trials as Topic; Humans; Isotopes; Neoplasms; Phantoms, Imaging; Phenylalanine; Radiation-Sensitizing Agents; Radiometry; Radiotherapy Dosage; Radiotherapy Planning, Computer-Assisted; Reproducibility of Results; Software; Treatment Outcome | 2008 |
Suitability of boron carriers for BNCT: accumulation of boron in malignant and normal liver cells after treatment with BPA, BSH and BA.
Topics: Animals; Boric Acids; Borohydrides; Boron; Boron Compounds; Boron Neutron Capture Therapy; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Clone Cells; Hepatocytes; Humans; Liver Neoplasms; Phenylalanine; Radiation-Sensitizing Agents; Rats; Rats, Sprague-Dawley; Sulfhydryl Compounds; Tissue Distribution | 2009 |
PET pharmacokinetic analysis to estimate boron concentration in tumor and brain as a guide to plan BNCT for malignant cerebral glioma.
Topics: Algorithms; Astrocytoma; Boron; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Carbon Radioisotopes; Glioblastoma; Glioma; Humans; Methionine; Phenylalanine; Positron-Emission Tomography; Radiation-Sensitizing Agents; Radiotherapy Planning, Computer-Assisted | 2009 |
Biodistribution of BPA and BSH after single, repeated and simultaneous administrations for neutron-capture therapy of cancer.
Topics: Animals; Borohydrides; Boron; Boron Compounds; Boron Neutron Capture Therapy; Cricetinae; Female; Isotopes; Melanoma, Experimental; Mesocricetus; Phenylalanine; Radiation-Sensitizing Agents; Sulfhydryl Compounds; Tissue Distribution | 2009 |
Positron emission tomography and [18F]BPA: a perspective application to assess tumour extraction of boron in BNCT.
Topics: Boron; Boron Compounds; Boron Neutron Capture Therapy; Fluorine Radioisotopes; Humans; Isotopes; Lymphatic Metastasis; Melanoma; Models, Biological; Neoplasms; Phenylalanine; Positron-Emission Tomography; Prognosis; Radiation-Sensitizing Agents; Tomography, X-Ray Computed | 2009 |
Biodistribution of (10)B for Boron Neutron Capture Therapy (BNCT) in a mouse model after injection of sodium mercaptoundecahydro-closo-dodecaborate and l-para-boronophenylalanine.
Topics: Animals; Borohydrides; Boron; Boron Compounds; Boron Neutron Capture Therapy; Drug Therapy, Combination; Injections; Isotopes; Male; Mice; Organ Specificity; Phenylalanine; Sulfhydryl Compounds; Tissue Distribution | 2009 |
Boron uptake measurements in a rat model for Boron Neutron Capture Therapy of lung tumours.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Boron; Boron Compounds; Boron Neutron Capture Therapy; Disease Models, Animal; Lung Neoplasms; Phenylalanine; Rats | 2011 |
Artificial neural networks to evaluate the boron concentration decreasing profile in blood-BPA samples of BNCT patients.
Topics: Boron; Boron Compounds; Boron Neutron Capture Therapy; Humans; Neural Networks, Computer; Phenylalanine | 2011 |
Qualitative autoradiography with polycarbonate foils enables histological and track analyses on the same section.
Topics: Animals; Autoradiography; Boranes; Boron; Humans; Liver; Melanoma; Mice; Mice, Nude; Neoplasms, Experimental; Phenylalanine; Polycarboxylate Cement | 2013 |
(10)B-NMR determination of (10)B-BPA, (10)B-BPA-fructose complex and total (10)B in blood for BNCT.
Topics: Blood Chemical Analysis; Boron; Boron Compounds; Boron Neutron Capture Therapy; Fructose; Humans; Isotopes; Magnetic Resonance Spectroscopy; Phenylalanine; Reproducibility of Results; Sensitivity and Specificity | 2014 |
Quantitative evaluation of boron neutron capture therapy (BNCT) drugs for boron delivery and retention at subcellular-scale resolution in human glioblastoma cells with imaging secondary ion mass spectrometry (SIMS).
Topics: Boron; Boron Compounds; Boron Neutron Capture Therapy; Calcium; Cell Line, Tumor; Cell Tracking; Glioblastoma; Humans; Intracellular Space; Isotopes; Microscopy, Confocal; Phenylalanine; Potassium; Sodium; Spectrometry, Mass, Secondary Ion; Time Factors | 2014 |
Blood-brain barrier (BBB) toxicity and permeability assessment after L-(4-¹⁰Boronophenyl)alanine, a conventional B-containing drug for boron neutron capture therapy, using an in vitro BBB model.
Topics: Animals; Blood-Brain Barrier; Boron; Boron Compounds; Brain; Capillary Permeability; Cattle; Coculture Techniques; Cytoskeleton; Endothelial Cells; Neuroglia; Occludin; Phenylalanine; Pilot Projects; Rats; Tight Junctions; Vimentin; Zonula Occludens-1 Protein | 2014 |
The effectiveness of the high-LET radiations from the boron neutron capture [10B(n,α) 7Li] reaction determined for induction of chromosome aberrations and apoptosis in lymphocytes of human blood samples.
Topics: Apoptosis; Borohydrides; Boron; Boron Compounds; Boron Neutron Capture Therapy; Chromosome Aberrations; Dose-Response Relationship, Radiation; Female; Humans; Isotopes; Linear Energy Transfer; Lithium; Lymphocytes; Male; Neutrons; Phenylalanine; Radiation-Sensitizing Agents; Sulfhydryl Compounds | 2015 |
Boronophenylalanine, a boron delivery agent for boron neutron capture therapy, is transported by ATB0,+, LAT1 and LAT2.
Topics: Amino Acid Transport System y+; Amino Acid Transport System y+L; Amino Acid Transport Systems; Animals; Biological Transport; Boron; Boron Compounds; Boron Neutron Capture Therapy; Cell Line, Tumor; Fusion Regulatory Protein 1, Light Chains; HeLa Cells; Humans; MCF-7 Cells; Neurotransmitter Transport Proteins; Oocytes; Phenylalanine; RNA Interference; RNA, Small Interfering; Xenopus | 2015 |
Detection of boronic acid derivatives in cells using a fluorescent sensor.
Topics: Antineoplastic Agents; Boron; Boron Compounds; Boronic Acids; Bortezomib; Cell Line, Tumor; Chelating Agents; Fluorescent Dyes; Humans; Optical Imaging; Phenylalanine; Spectrometry, Fluorescence | 2015 |
Experimental Studies of Boronophenylalanine ((10)BPA) Biodistribution for the Individual Application of Boron Neutron Capture Therapy (BNCT) for Malignant Melanoma Treatment.
Topics: Animals; Body Temperature; Boron; Boron Compounds; Boron Neutron Capture Therapy; Cell Line, Tumor; Humans; Ki-67 Antigen; Melanoma; Melanoma, Cutaneous Malignant; Mice; Mice, Nude; Phenylalanine; Platelet Endothelial Cell Adhesion Molecule-1; Radioisotopes; Skin Neoplasms; Tissue Distribution; Tumor Burden | 2015 |
Biodistribution of boron after intravenous 4-dihydroxyborylphenylalanine-fructose (BPA-F) infusion in meningioma and schwannoma patients: A feasibility study for boron neutron capture therapy.
Topics: Adult; Aged; Boron; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Feasibility Studies; Female; Fructose; Humans; Infusions, Intravenous; Male; Meningioma; Middle Aged; Neurilemmoma; Phenylalanine; Tissue Distribution; Young Adult | 2015 |
The N-B Interaction through a Water Bridge: Understanding the Chemoselectivity of a Fluorescent Protein Based Probe for Peroxynitrite.
Topics: Amino Acid Sequence; Boron; Boron Compounds; Crystallography, X-Ray; Fluorescent Dyes; Green Fluorescent Proteins; Hydrogen Peroxide; Magnetic Resonance Spectroscopy; Models, Molecular; Mutagenesis, Site-Directed; Peroxynitrous Acid; Phenylalanine; Sequence Alignment; Spectrometry, Fluorescence; Water | 2016 |
A Model for Estimating Dose-Rate Effects on Cell-Killing of Human Melanoma after Boron Neutron Capture Therapy.
Topics: Boron; Boron Compounds; Boron Neutron Capture Therapy; Cell Death; Cell Line, Tumor; Cell Survival; Cobalt Radioisotopes; Computer Simulation; Dose-Response Relationship, Radiation; Gamma Rays; Humans; Isotopes; Melanoma; Models, Biological; Monte Carlo Method; Neutrons; Phenylalanine; Radiometry; Relative Biological Effectiveness; Time Factors | 2020 |
Boron phenyl alanine targeted ionic liquid decorated chitosan nanoparticles for mitoxantrone delivery to glioma cell line.
Topics: Antineoplastic Agents; Boron; Cell Line, Tumor; Chitosan; Glioma; Humans; Microscopy, Electron, Transmission; Mitoxantrone; Nanoparticle Drug Delivery System; Nanoparticles; Phenylalanine | 2021 |
Efficacy of Boron Neutron Capture Therapy in Primary Central Nervous System Lymphoma: In Vitro and In Vivo Evaluation.
Topics: Animals; Apoptosis; Boron; Boron Neutron Capture Therapy; Brain; Cell Line, Tumor; Cell Survival; Central Nervous System Neoplasms; Cranial Irradiation; Disease Models, Animal; Humans; Lymphoma; Methotrexate; Mice; Phenylalanine; Tissue Distribution | 2021 |
Evaluation of the Key Advantages between Two Modalities of Boronophenylalanine Administration for Clinical Boron Neutron Capture Therapy Using an Animal Model.
Topics: Animals; Boron; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Carcinoma, Squamous Cell; Disease Models, Animal; Humans; Mouth Neoplasms; Phenylalanine | 2022 |
A Red-Emitting Fluorescence Sensor for Detecting Boronic Acid-Containing Agents in Cells.
Topics: Boron; Boron Compounds; Boron Neutron Capture Therapy; Boronic Acids; Cell Line, Tumor; Fluorescence; Phenylalanine | 2022 |
Boronotyrosine, a Borylated Amino Acid Mimetic with Enhanced Solubility, Tumor Boron Delivery, and Retention for the Re-emerging Boron Neutron Capture Therapy Field.
Topics: Amino Acids; Boron; Boron Compounds; Boron Neutron Capture Therapy; Cell Line, Tumor; Phenylalanine; Solubility | 2023 |
Investigation of the Impact of L-Phenylalanine and L-Tyrosine Pre-Treatment on the Uptake of 4-Borono-L-Phenylalanine in Cancerous and Normal Cells Using an Analytical Approach Based on SC-ICP-MS.
Topics: Animals; Boron; Boron Compounds; Boron Neutron Capture Therapy; Cricetinae; Humans; Phenylalanine; Spectrum Analysis; Tyrosine | 2023 |
Assessing the effectiveness of fluorinated and α-methylated 3-boronophenylalanine for improved tumor-specific boron delivery in boron neutron capture therapy.
Topics: Boron; Boron Compounds; Boron Neutron Capture Therapy; Humans; Neoplasms; Phenylalanine; Tissue Distribution; Water | 2024 |